CN101707900A - Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same - Google Patents
Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same Download PDFInfo
- Publication number
- CN101707900A CN101707900A CN200880014150A CN200880014150A CN101707900A CN 101707900 A CN101707900 A CN 101707900A CN 200880014150 A CN200880014150 A CN 200880014150A CN 200880014150 A CN200880014150 A CN 200880014150A CN 101707900 A CN101707900 A CN 101707900A
- Authority
- CN
- China
- Prior art keywords
- ceramide
- composition
- wax
- emulsion composition
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
Provided are an emulsion composition containing a nanosized (10 to lOOOnm) ceramide capsule particle stabilized by doubly encapsulating with wax matrix and polymer, a preparation method of the emulsion composition, and a skin cosmetic composition using the emulsion composition. More particularly, provided is an emulsion composition having superior stability with time in spite of high ceramide content, which is attained by effectively inhibiting gelling between ceramide molecules through trapping ceramide in solid wax matrix and then en not capsulating the wax matrix using polymer. In accordance with the present invention, ceramide, a skin lipid component with excellent moisturizing effect, is prepared into a stable emulsion through being trapped in a nanosized capsule particle, which provides improved dermal delivery and adhesion to skin, and improved and long-lasting moisturizing effect.
Description
Technical field
The present invention relates to a kind of emulsion composition that comprises nanoscale (10-1000nm) capsule particle, ceramide wherein adopts wax and polymer to be stablized the skin cosmetic composition that also relates to the preparation method of this emulsion composition and adopt this emulsion composition by dual packaged.Particularly, even the present invention relates to a kind of emulsion composition that under the ceramide content condition with higher, still can keep outstanding stability for a long time, this outstanding stability is by wrapping up ceramide with wax, then with this wax-matrix of polymer encapsulated, thereby the gelling that effectively suppresses between the ceramide molecule realizes.
Background technology
In general, cosmetics be used for keeping human body cleaning, improve appearance, protection skin or hair are avoided the puzzlement of problems such as ultraviolet radiation, drying and are prevented aging.Along with the industrialization of society and the increase of social activity, people express individual's consciousness of oneself more and more energetically, and it beautifies skin and keeps the hope of skin health also strong day by day.Therefore, people are devoted to study and develop the basic and chromatic cosmetics of all kinds and form.Especially what deserves to be mentioned is that the demand that client avoids the skin moisturizing cosmetics of dry problem puzzlement to the protection skin constantly increases.
Skin mainly constitutes by three layers: epidermal area, skin corium and hypodermal layer, the major function of skin are physics and the chemical stimulations that the protection human body is avoided external environment.Especially what deserves to be mentioned is, skin the moisture that prevents to account for the about 65-70% of human body from human body evaporate away aspect play an important role, this moisture is responsible for carrying the needed various biological active substanceies of human body, and keeps the skin softness moistening.Epidermal area is divided into horny layer, granular layer, spinous layer and basal layer (linking to each other with skin corium) again.The function and the fragment of brick of corneocyte are similar, and the lipid between the keratinocyte is then like mortar.The two has just formed the barrier of skin with this combination.Horny layer is the outermost layer of epidermis, contains the moisture of about 10-20%, can prevent intravital water evaporates, and hinders too much foreign substance and infiltrate in the body.Cuticular surface is covered by the very thin natural protecting film of one deck that perspiration constituted of the sebum of smegma and sweat gland secretion, can prevent water evaporates.This is surrounded by waterproof plastic film (natural protecting film) just as the sponge (horny layer) that is immersed in the water.Equally, the spissated water-soluble natural Moisture factor of corneocyte camber (NMF) also can keep skin soft moist.
However, because a variety of causes, comprise the variation of the skin environment of living in that causes because of living environment or life pattern change, heating and/or refrigerating artificial temperature control, the various pressure that various social activity and environmental pollution bring, ultraviolet radiation, the frequent clean that causes because of cosmetic, skin factors such as natural aging in time are to pressure that skin caused, cuticular moisture content can reduce gradually, and that skin also can become is dry, coarse, obscure, lackluster.In order to address this problem, people are actively developing research, improve the mode of skin moisture-keeping and barrier function with searching.
Usually, absorb the wetting agent of moisture or prevent that the enclosed type wetting agent of water evaporates once was used to improve cuticular moisture content. for wetting agent, the most widely used is polyhydric alcohol, as glycerol, propanol, 1, the 3-butanediol, Polyethylene Glycol etc. but because the viscosity and the physical characteristic of polyhydric alcohol, these applying materials are when skin, can feel moist sticky. in addition, its moisture-keeping efficacy can decrease in dry environment, and, because their water solubles, therefore moisture-keeping efficacy is not lasting. for the enclosed type wetting agent, once used the picture soothing oil, lipid and essential fatty acid and lipid mixtures etc. such as ceramide. though the moisture-keeping efficacy of soothing oil is abundant inadequately, but the moisture-keeping efficacy of ceramide is very outstanding. the lipid molecular that ceramide is in the horny layer to be rich in, it can be remarkable, prevent that effectively the skin internal moisture is outwards lost, the barrier of resisting external environment is provided. therefore, this class material has become the choosing of the material of extensively being paid close attention in the skin moisture-keeping product in the cosmetic industry.
But,, when therefore it being prepared into Emulsion, can weaken the stability of product owing to comprise that the lipid matter of ceramide can disturb the membrane structure at interface.And the character of product often changes because of the self-solidifying effect in time.Therefore, the use of ceramide in cosmetics also faces many problems, and it can only be used for special product form very a small amount of or limitedly at present.
Summary of the invention
Technical problem
The present inventor is devoted to by the dual packaged to ceramide, develops a kind of good long-time stability that have, and has the emulsion composition of high-load ceramide simultaneously.They adopt the dual packaged of the incompatible realization ceramide of the suitable groups of wax and polymer, thereby suppress the interaction between the ceramide molecule, and prevention is passed in time and produced the phenomenon of gel.And they improve its importing and adhesiveness to skin by nano-particleization at intention, by improving and keeping its moisture-keeping efficacy to promote its value as cosmetics.
Therefore, one of purpose of the present invention provides a kind of the have outstanding long-time stability and the emulsion composition of good and persistent moisture-keeping functions, comprise dual packaged, nano level ceramide capsule particle in the said composition, the present invention also provides the preparation method of said composition.In addition, another object of the present invention provides a kind of cosmetic composition that uses this emulsion composition.
Technical scheme
From on the one hand, the invention provides a kind of capsular emulsion composition of ceramide that contains, wherein comprise: i) as the ceramide of core; Ii) wrap up the wax-matrix layer of ceramide; And the ceramide that iii) will be wrapped in the wax-matrix is packaged into capsular polymeric layer.
From another aspect, the invention provides a kind of preparation method that contains the capsular emulsion composition of ceramide, comprising: the employing homogenizer heats ceramide, wax and polymer and disperses, and makes its mixing simultaneously, with preparation lipotropy mixture; Water composition is mixed, and make water composition emulsifying by slowly adding above-mentioned lipotropy mixture in hydrotropism's composition.
Beneficial effect
According to one embodiment of present invention, contain the gelation that can effectively prevent ceramide by the emulsion composition of the ceramide of wax and polymer dual packaged.In addition, according to another embodiment of the invention, adopt general intimate mixing method, with ceramide, a kind of skin lipid composition with fabulous moisture-keeping efficacy, make a kind of stable Emulsion by being rolled into nano level capsule particle, it can improve its importing and adhesiveness to skin, and improves and realize persistent moisture-keeping efficacy.
Below the present invention will be described in further detail.
In one embodiment of the invention, the capsule particle in the emulsion composition can have 10 to 1000nm nanometer grade diameter.When diameter during greater than 1000nm, expectation can't improve it to the importing of skin and to the adhesiveness of skin.When diameter during less than 10nm, then owing to need to use expensive emulsifying instrument, business efficiency is low, therefore is not suitable for the commercialization of cosmetics.
In one embodiment of the invention, ceramide component in the emulsion composition may account for the 1.0-10.0 weight % of OAV (oil-in-water) composition total weight, be preferably 2.0-5.0 weight %. when its content is lower than 1.0 weight %, then be difficult to realize good moistening effect. when its content surpasses 10.0 weight %, because the composition of wax and polymer can't effectively encapsulate and make the ceramide component stable, stability will reduce rapidly along with the time.
In one embodiment of the invention, the solid wax composition in the emulsion composition may account for the 3.0-30.0 weight % of OAV (oil-in-water) composition total weight, is preferably 5.0-20.0 weight %.When its content is lower than 3.0 weight %, because the ceramide component can't fully be wrapped up therefore stable variation in time.When its content surpasses 30.0 weight %, then, and be difficult to granule is made the nanometer size advantage of aspect such as realize that the present invention has outward appearance and physical characteristic preferably, use is comfortable and moisture-keeping efficacy is good because mastic hardens.
In one embodiment of the invention, the component of polymer in the Emulsion compound can account for the 0.1-3.0 weight % of composition total weight.When its content is lower than 0.1 weight %, be difficult to effectively encapsulate the ceramide of wax-matrix parcel.And when its content surpassed 3.0 weight %, because the deterioration of emulsifiability and comfort, cosmetics may be not easy to smear.
In one embodiment of the invention, emulsion composition can comprise: as the ceramide of the effective ingredient that moisture-keeping efficacy is provided; At least a is solid at room temperature, is selected from the wax-matrix component of aliphatic alcohol, fatty acid, vegetable wax, synthetic wax, ceresine, spermaceti, Cera Flava, lipid and peptide lipid; At least a polymers compositions that is selected from inulin, inulin derivant, xanthan gum, carbomer glue, polyacrylamide and PEG-PCL block copolymer.
In one embodiment of the invention, the wax composition in the emulsion composition can be Cera Flava, ceresine, spermaceti, stearic acid, palmityl alcohol, batilol or glyceryl monostearate.The wax composition at room temperature forms hard crystallization, thereby avoids ceramide in the capsule to be diffused into water or interface and form gel.Therefore, the wax composition has solved the product stability problems that ceramide causes.And it is harmless to skin, can remove foreign body sensation.
In one embodiment of the invention, the component of polymer in the emulsion composition can be the inulin derivant, for example lauryl carbaminate inulin, or block copolymer, for example methoxyl group PEG-114/ polycaprolactone.Because polymer has surface activity, it can be attracted between the ceramide that wrapped up wax-matrix and the water at the interface, thereby encapsulates wax-matrix effectively.In one embodiment of the invention, the skin care cosmetic compositions that comprises above-mentioned emulsion composition can be the cosmetics of any kind or type, and is not subjected to any restriction.For instance, its form can be a kind of in toner/smoothing toner, cosmetic water, active nourishing lotion, emollient cream, massage cream, eye cream, eye elite, cleansing cream, facial milk cleanser, facial cleansing foam, clean water, bag, powder, profit body breast, profit body frost, profit body elite, bath gel, hair dye, shampoo, purificant, toothpaste, collutory, hair conditioner, hair oil, emulsion, ointment, gel, cream, pad pasting and the spraying.
Description of drawings
Fig. 1 has provided the results of grain size analysis among the embodiment 1;
Fig. 2 is smearing through the mouse of acetone treatment and is containing the ceramide capsule or do not contain under the situation of ceramide capsule composition the comparison of TEWL (percutaneous aqueous dispersion vector) change in value;
Fig. 3 human body contains the ceramide capsule or does not contain under the situation of ceramide capsule composition the comparison of TEWL (percutaneous aqueous dispersion vector) change in value smearing;
Fig. 4 contains the ceramide capsule or does not contain under the situation of ceramide capsule composition the comparison of the water content of human body skin smearing.
The specific embodiment
To the present invention be described in further detail by embodiment below, still, following examples can't be construed as limiting scope of the present invention.
Embodiment 1 and comparing embodiment 1-3: adopt wax and component of polymer to prepare stable ceramide emulsion composition
The oiliness composition (#1-3) that provides in table 1 in independent container mixes, and is heated to 70 ℃ simultaneously, and uses homogenizer to disperse, with preparation lipotropy mixture.(#4-6) mixes with water composition, is heated to 70 ℃ simultaneously, and by slowly adding the lipotropy mixture in hydrotropism's composition, carries out emulsifying at 70 ℃.In ice bath, carry out quenching after the emulsifying and handle, add antiseptic subsequently.At last, with the emulsion composition sealed container of packing into, use the cooler cool to room temperature.
Table 1
| Component | The comparative example 1 | The comparative example 2 | The comparative example 3 | Embodiment 1 |
| 1, ceramide | ?3.0 | ?3.0 | ?3.0 | ?3.0 |
| 2, Cera Flava | ?- | ?10.0 | ?- | ?10.0 |
| 3, lauryl carbaminate inulin | ?- | ?- | ?1.0 | ?1.0 |
| 4, pure water | To 100 | To 100 | To 100 | To 100 |
| 5, glycerol | ?10.0 | ?10.0 | ?10.0 | ?10.0 |
| 6, butanediol | ?10.0 | ?10.0 | ?10.0 | ?10.0 |
| 7, parabens mixture solution (antiseptic) | ?0.1 | ?0.1 | ?0.1 | ?0.1 |
The time dependent stability of stabilisation ceramide capsule, outward appearance and the grain size analysis of test case 1: embodiment 1 and comparing embodiment 1-3
Preparation back sample drawn from the compositions of embodiment 1 and comparing embodiment (1-3).At second day for preparing and after storing 30 days under 45 ℃ the constant temperature, stability, outward appearance and granularity are analyzed.The result is as shown in table 2.After storing 30 days under 45 ℃ the constant temperature, use Particle Size Analyzer to measure granularity.
Table 2
| Summary | Stability during preparation | 45 ℃ of stability that store down after 1 month | Outward appearance | Granularity |
| The comparative example 1 | Creaming appears | The complete layering of oil phase | Double-deck phase | Immeasurability |
| The comparative example 2 | Creaming appears | The complete layering of oil phase | Double-deck phase | Immeasurability |
| The comparative example 3 | Stable | Assemble between granule | The butterfat phase | Immeasurability |
| Embodiment 1 | Stable | Stable | Low viscosity emulsion phase | ??250nm |
As shown in table 2, stability can be subjected to the influence of institute's content of wax and component of polymer.Do not use wax and polymer to carry out under the situation of dual packaged (comparing embodiment 1-3), can't prepare stable emulsion composition or that the emulsion composition made is passed in time is stable very poor.Under the situation of not using wax (comparing embodiment 3), the ceramide component can be moved to the interface, and forms gel.Under the situation of not using polymer (comparing embodiment 1 and 2), because the interfacial tension height, separation of oil can't realize effective nano-particleization, therefore can't be prepared into cosmetics.In embodiment 1, produced the Emulsion of milk shape, the granule that is dispersed in the Emulsion is wrapped in ceramide.The granularity of embodiment 1 adopts Zetasizer 3000HS (Ma Erwen Instr Ltd.) to analyze.As shown in Figure 1, the result is very desirable, and mean diameter is 148.4nm, and polydispersity, promptly a kind of tolerance of granularity deviation is 0.215.
Embodiment 2-3 and comparing embodiment 4-5: preparation contains the cosmetic composition that comprises stabilisation ceramide nano capsule Emulsion
Moisture-keeping efficacy for the ceramide nano capsule of assessing stabilisation, adopt the compositions of embodiment 1 to prepare ceramide capsule essential part (emulsion-type), and it is added in common Emulsion (OVA) type cosmetic composition (embodiment 2 and comparing embodiment 4) and the gel-type cosmetic composite (embodiment 3 and comparing embodiment 5), the concentration with 10% adopts table 3, and (unit: the component percentage by weight) is prepared.But the capsular concentration of the ceramide of stabilisation is not limited to this specific example.
Table 3
1. the preparation of Emulsion (O/W) in embodiment 2 and the comparing embodiment 4
(1) makes its uniform mixing in the time of with oiliness composition heating (70-75 ℃).
(2) make its uniform mixing in the time of with water composition heating (70-75 ℃).
(3) the oiliness composition with (1) adds in the water composition 1 of (2), and stirs under 70-75 ℃ simultaneously.In the emulsion-type cosmetic composition that is generated, add water composition 2 continuously, and be cooled to 28-30 ℃.
2. the preparation of gel in embodiment 3 and the comparing embodiment 5
(1) with water composition 1 uniform mixing.
(2) with pure composition uniform mixing.
(3) when stirring, in the water composition 1 of (1), slowly add water composition 2.After concentrating, add pure composition continuously, to obtain gel-type cosmetic composite.
Test case 2: the assessment of the skin moisture-keeping effect of prepared cosmetic composition
1. animal testing
With acetone regularly be applied to 8-10 week big childhood nude mice the back, used continuously 5 days every day twice, to destroy the barrier function of skin.Adopt atmidoscope to measure TEWL (percutaneous aqueous dispersion vector).Have only the mouse of TEWL value 〉=40g/m/hr could accept following experiment.By predetermined time interval determination TEWL, to smear embodiment 2-3 simultaneously and relatively execute the compositions of routine 4-5, dosage is every 5cm skin area 200 μ L, every day 2 times, uses continuously 3 days.Measurement result as shown in Figure 2.
As shown in Figure 2, it is lower to contain its TEWL value of passing in time of cosmetic composition of stabilisation ceramide capsule (embodiment 2-3).This explanation is compared with not containing capsular compositions (comparing embodiment 4-5), and the compositions that contains stabilisation ceramide capsule (embodiment 2-3) has better moisture-keeping efficacy and skin barrier effect
2. human test
15 complaint xerosis cutiss or suspect that self xerodermatic masculinity and femininity adult is divided into two groups.Every group of object of study smeared the cosmetic composition of embodiment 2 and comparing embodiment 4, embodiment 3 and comparing embodiment 5 at face, every day twice, uses for 4 weeks continuously.Under the condition of maintenance temperature and humidity constant (24 ℃, relative humidity 40%), before bringing into use, use 1 all backs, after 2 weeks and after 4 weeks, come the comparison moisture-keeping efficacy by measuring TEWL.The result as shown in Figure 3.In addition, also should use skin moisture tester (corneometer) to measure the water content of skin.The result as shown in Figure 4.
(1) mensuration of TEWL
TEWL is that the water yield by shown area of temperature and humidity pick off and the evaporation of Time Calculation skin records.The assay method of TEWL is as follows.
1) keeps temperature and humidity constant, only allow gauger and object of study to stay in the measuring cell, in order to avoid air flows.
2) the TEWL probe is placed on the mensuration position of object of study.
3) make probe contact skin gently, keep probe to become an angle of 90 degrees with the surface.
4) wait when the TEWL value no longer changes, was write down the TEWL value after 1-3 minute.
5) catch handle, as far as possible away from probe, in order to avoid the personnel's of mensuration body temperature conducts.
6) evaporated water of unit of account square measure time (g/m/h).
As shown in Figure 3, it is lower to contain its time dependent TEWL value of the capsular cosmetics compound of stabilisation ceramide (embodiment 2-3), referring to Fig. 2.Therefore, can confirm to contain the capsular cosmetic composition of stabilisation ceramide (embodiment 2-3) and not have better moisture-keeping efficacy than not containing capsular compositions (comparing embodiment 4-5).
Comparative example 2 and embodiment 3, embodiment 2 have shown good slightly moisture-keeping efficacy under identical stabilisation ceramide capsule content.This may be because the emulsion-type synthetic has better moisture-keeping efficacy than gel in general.
(2) adopt the skin moisture analyzer to measure the water content of skin
The skin moisture analyzer is a kind of by using the instrument of sensor determination water concentration and then mensuration skin corium water content.The assay method of moisture content of skin is as follows.
1) probe with the skin moisture analyzer is placed on the mensuration position.
2) make probe contact skin, on screen, demonstrate the electric capacity of the skin of measuring by pick off subsequently.
3) measure repeatedly at different mensuration positions.
4) each mensuration is back with cotton paper or Kimberly cleansing tissue wiping pick off.
As shown in Figure 4, pass in time, the water content among the embodiment 2-3 is higher than comparing embodiment 4-5.This explanation is compared with comparing embodiment 4-5, and embodiment 2-3 has better, more persistent moisture-keeping efficacy.
Except TEWL and moisture determination, also when EOT,, carry out subjective efficacy assessment by allowing object of study fill in the questionnaire of the situation of improving about xerosis cutis.The result of questionnaire is as shown in table 4.
Table 4
As shown in table 4, use the object of study of the compositions of embodiment 2-3 to experience better moisture-keeping efficacy than the object of study of the compositions of using comparing embodiment 4-5.
Be illustrated as illustration although the preferred embodiments of the present invention are open, but those skilled in the art figures out under the situation of scope and spirit of the present invention illustrated in not departing from the claim of enclosing, and can realize various improvement, interpolation and alternative.
Claims (18)
1. one kind contains the capsular emulsion composition of ceramide, and this capsule comprises: i) ceramide core; Ii) wrap up the wax layer of ceramide; And the polymeric layer that iii) encapsulates the ceramide that is wrapped up by the wax layer.
2. the described emulsion composition of claim 1, the capsular diameter of ceramide wherein is 10-1000nm.
3. the described emulsion composition of claim 1, ceramide wherein accounts for the 1.0-10.0 weight % of composition total weight.
4. the described emulsion composition of claim 1, wax wherein accounts for the 3.0-30.0 weight % of composition total weight.
5. the described emulsion composition of claim 1, polymer wherein accounts for the 0.1-3.0 weight % of composition total weight.
6. the described emulsion composition of claim 1, wax wherein at room temperature is solid.
7. the described emulsion composition of claim 6, wax wherein are selected from a kind of in aliphatic alcohol, fatty acid, vegetable wax, synthetic wax, ceresine, spermaceti, Cera Flava, lipid and the peptide lipid at least.
8. the described emulsion composition of claim 1, polymer wherein are to be selected from a kind of in inulin, inulin derivant, xanthan gum, carbomer glue, polyacrylamide and the PEG-PCL block copolymer at least.
9. skin care cosmetic compositions that comprises any one described emulsion composition of claim 1-8.
10. the described skin care cosmetic compositions of claim 9, the form of said composition are selected from a kind of in toner/smoothing toner, cosmetic water, moist gentle peptide water, emollient cream, massage cream, eye cream, eye elite, cleansing cream, facial milk cleanser, facial cleansing foam, clean water, bag, powder, profit body breast, profit body frost, profit body elite, bath gel, hair dye, shampoo, purificant, toothpaste, collutory, hair conditioner, hair oil, emulsion, ointment, gel, cream, pad pasting and the spraying.
11. one kind prepares the method that contains the capsular emulsion composition of ceramide, comprising:
Using homogenizer that ceramide, wax and polymer are heated and dispersively making its mixing simultaneously, with preparation lipotropy mixture;
With the water composition heating and by the lipotropy mixture is slowly added its emulsive water composition that makes is simultaneously mixed.
12. the described preparation method of claim 11, ceramide wherein account for the 1.0-10.0 weight % of composition total weight.
13. the described preparation method of claim 11, wax wherein account for the 3.0-30.0 weight % of composition total weight.
14. the described preparation method of claim 11, polymer wherein account for the 0.1-3.0 weight % of composition total weight.
15. the described preparation method of claim 11, wax wherein at room temperature are solid.
16. the described preparation method of claim 15, wax wherein are to be selected from a kind of in aliphatic alcohol, fatty acid, vegetable wax, synthetic wax, ceresine, spermaceti, Cera Flava, lipid and the peptide lipid at least.
17. the described preparation method of claim 11, polymer wherein are to be selected from a kind of in inulin, inulin derivant, xanthan gum, carbomer glue, polyacrylamide and the PEG-PCL block copolymer at least.
18. the described preparation method of claim 11, wherein water composition comprises pure water, glycerol or alkylene glycols.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2007-0041831 | 2007-04-30 | ||
| KR1020070041831A KR100837558B1 (en) | 2007-04-30 | 2007-04-30 | Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same |
| PCT/KR2008/002464 WO2008133482A1 (en) | 2007-04-30 | 2008-04-30 | Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101707900A true CN101707900A (en) | 2010-05-12 |
| CN101707900B CN101707900B (en) | 2013-02-06 |
Family
ID=39771054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008800141500A Active CN101707900B (en) | 2007-04-30 | 2008-04-30 | Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR100837558B1 (en) |
| CN (1) | CN101707900B (en) |
| WO (1) | WO2008133482A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690391A (en) * | 2013-12-27 | 2014-04-02 | 苏州纳康生物科技有限公司 | Ceramide nanoemulsion and preparation method thereof |
| CN107929229A (en) * | 2017-12-19 | 2018-04-20 | 广州市仙婷贸易有限公司 | A kind of bilayer lotion |
| CN110494116A (en) * | 2017-03-27 | 2019-11-22 | 赢创德固赛有限公司 | It is used to prepare the method and product of the formulation containing ceramide |
| CN111615379A (en) * | 2018-01-19 | 2020-09-01 | 株式会社Lg生活健康 | Cosmetic composition comprising particles containing high content of ceramide and method for producing same |
| CN111867556A (en) * | 2018-03-27 | 2020-10-30 | 株式会社爱茉莉太平洋 | Liquid lipid complex composition for improving hair condition |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009044891A1 (en) * | 2009-12-14 | 2011-06-16 | Gabriele Dr. Blume | Carrier system for inclusion of lipophilic drugs and oils in high concentration |
| WO2011080741A2 (en) | 2009-12-31 | 2011-07-07 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| US11071878B2 (en) | 2009-12-31 | 2021-07-27 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| US10653899B2 (en) | 2009-12-31 | 2020-05-19 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| DE102010001905A1 (en) * | 2010-02-12 | 2011-08-18 | ROVI Cosmetics International GmbH, 36381 | UV protection agent for the skin or the hair with a UV filter substance encapsulated in a vesicular carrier system |
| DE102011116069A1 (en) | 2011-10-18 | 2013-04-18 | Dr. Rimpler Gmbh | Lipid nanoparticle dispersion, process for its preparation and its use |
| KR101762011B1 (en) | 2015-09-02 | 2017-07-26 | 최화숙 | Cosmetic composition capable of triple matrix encapsulation and method for manufacturing the same |
| KR20170038249A (en) | 2015-09-30 | 2017-04-07 | (주)아모레퍼시픽 | High-Ceramide-Content Nano Emulsion Improved in Transparency, Composition of Cosmetic Comprising Thereof and Manufacturing Method Thereof |
| BR102015032894A2 (en) * | 2015-12-29 | 2017-07-04 | Natura Cosméticos S.A. | COMPOSITION OF BUTYL METHOXIDIBENZOYLMETHANE, HYDROXYBENZOYL HEXYLBENZOATE DIETHYLAMINE, ETHYL HEXYL SALICYLATE, HOMOSALATE AND NANOOCAPYLENE NANOENCAPSULATED IN NON-STRUMMURE FILM |
| KR102032275B1 (en) | 2018-04-05 | 2019-10-16 | 안호영 | Nanoscale encapsulation formulation of active ingredient chemicals using multicomponent polymer system |
| KR102070557B1 (en) * | 2019-06-25 | 2020-01-29 | 코스맥스 주식회사 | A cosmetic composition comprising a ceramide containing capsule |
| KR102278422B1 (en) | 2019-10-02 | 2021-07-19 | 안호영 | Pesticide composition comprising nanoscale encapsulation formulation of active ingredient chemicals using multicomponent polymer system |
| KR102394035B1 (en) * | 2020-06-02 | 2022-05-04 | 코스맥스 주식회사 | Ceramide-containing cosmetic composition using high-pressure homogenizer and method for manufacturing the same |
| KR20240015891A (en) | 2022-07-28 | 2024-02-06 | 주식회사 수안향장 | Manufacturing method of double matrix capsule |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0182599B1 (en) * | 1996-07-13 | 1999-05-01 | 손경식 | Shampoo composition strengthening internal tissues of hair |
| FR2759902A1 (en) * | 1997-02-24 | 1998-08-28 | Clarins | Lipstick |
| FR2788689B1 (en) * | 1999-01-27 | 2002-06-07 | Oreal | COSMETIC COMPOSITION COMPRISING AT LEAST ONE WAX AND AT LEAST ONE CERAMID-LIKE COMPOUND AND METHODS |
| KR100439595B1 (en) * | 2001-05-18 | 2004-07-12 | 주식회사 엘지생활건강 | Tocopherol-containing Ceramide Liquid Crystal Capsule, Emulsion thereof and Cosmetic comprising the same |
| FR2832616B1 (en) * | 2001-11-29 | 2004-01-09 | Oreal | ANTI-SEBUM PAPER CONTAINING THERMOSTABILIZING MICROCAPSULES |
| ITMI20012599A1 (en) | 2001-12-11 | 2003-06-11 | Cosmo Spa | PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ADMINISTRATION OF HEPARINE OR DERIVATIVES, USEFUL FOR THERAPY OF INFLAMMATORY DISEASES OF THE INT |
| JP4149285B2 (en) * | 2003-02-14 | 2008-09-10 | ピジョン株式会社 | Ceramide-containing gel composition |
| KR101002433B1 (en) | 2003-09-19 | 2010-12-17 | 주식회사 엘지생활건강 | nano-emulsion comprsing vitamine A or its derivatives and acetyl hexapeptide-3, and anti-wrinkle cosmetic preparation including the same |
-
2007
- 2007-04-30 KR KR1020070041831A patent/KR100837558B1/en active IP Right Grant
-
2008
- 2008-04-30 WO PCT/KR2008/002464 patent/WO2008133482A1/en active Application Filing
- 2008-04-30 CN CN2008800141500A patent/CN101707900B/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690391A (en) * | 2013-12-27 | 2014-04-02 | 苏州纳康生物科技有限公司 | Ceramide nanoemulsion and preparation method thereof |
| CN103690391B (en) * | 2013-12-27 | 2016-08-17 | 苏州纳康生物科技有限公司 | A kind of Ceramide nanoemulsion and preparation method thereof |
| CN110494116A (en) * | 2017-03-27 | 2019-11-22 | 赢创德固赛有限公司 | It is used to prepare the method and product of the formulation containing ceramide |
| CN107929229A (en) * | 2017-12-19 | 2018-04-20 | 广州市仙婷贸易有限公司 | A kind of bilayer lotion |
| CN107929229B (en) * | 2017-12-19 | 2021-07-09 | 仙婷(广州)科技研发有限公司 | Double-layer emulsion |
| CN111615379A (en) * | 2018-01-19 | 2020-09-01 | 株式会社Lg生活健康 | Cosmetic composition comprising particles containing high content of ceramide and method for producing same |
| CN111615379B (en) * | 2018-01-19 | 2023-03-28 | 株式会社Lg生活健康 | Cosmetic composition comprising particles containing high content of ceramide and method for producing same |
| CN111867556A (en) * | 2018-03-27 | 2020-10-30 | 株式会社爱茉莉太平洋 | Liquid lipid complex composition for improving hair condition |
| CN111867556B (en) * | 2018-03-27 | 2023-12-26 | 株式会社爱茉莉太平洋 | Liquid lipid complex composition for improving hair state |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008133482A1 (en) | 2008-11-06 |
| KR100837558B1 (en) | 2008-06-12 |
| CN101707900B (en) | 2013-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101707900B (en) | Emulsion composition containing double-stabilized ceramide nano capsule, method for manufacturing the same, and cosmetic composition containing the same | |
| CN106456476A (en) | Compositions and methods for enhancing the topical application of a basic benefit agent | |
| CN103445975B (en) | Emulsification cosmetic composition | |
| CN104812363B (en) | Emulsification cosmetic | |
| CN108066240A (en) | A kind of moisturiser and preparation method thereof | |
| CN105796459A (en) | Moisturizing gel containing hydrolyzed pearl powder flexible nano liposome | |
| US20080160088A1 (en) | Composition containing hydroxyapatite and a calcium salt | |
| TW200934514A (en) | Topical composition | |
| CN103417466B (en) | Natural moisture-preserving and skin-protecting composition and application thereof in cosmetics | |
| KR20090017336A (en) | Cosmetic composition containing liquid crystal complex for enhancing moisturizing effect on the skin and for reducing skin roughness | |
| KR100904200B1 (en) | Cosmetic composition for moisturizing the skin containing the extract of Prunella Vulgaris and Aloe Barbadensis leaf | |
| KR101895037B1 (en) | Hydrogel comprising spicule and use thereof | |
| KR101096277B1 (en) | Cosmetic composition for moisturizing the skin | |
| CN101773452A (en) | Structured lotions | |
| KR101155807B1 (en) | Cosmetic composition for moisturizing and firming the skin | |
| KR101359947B1 (en) | Cosmetic composition containing moisturizing complex for moisturizing the skin | |
| Mast | Functions of glycerine in cosmetics | |
| KR101502027B1 (en) | Cosmetic composition containing Adansonia digitata fruit extract and hydrolyzed collagen for moisturizing and firming the skin | |
| CN113440443B (en) | Moisturizing composition, application thereof, essence and moisturizing mask | |
| Mane et al. | Formulation and Evaluation of Herbal Scrub Gel of Walnut Shell | |
| KR20130060618A (en) | Mask composition with high coverage to skin | |
| KR20130003107A (en) | Granular cosmetic pack composition for slush type wash-off pack and slush type wash-off pack using it | |
| KR100924643B1 (en) | Methods of Producing and liposomes entrapping atelocollagen | |
| JPS62153206A (en) | Skin cosmetic | |
| CN114533584B (en) | Collagenase anti-wrinkle face cream |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Address after: Seoul, South Kerean Applicant after: Amorepacific Corporation Address before: Seoul, South Korea Applicant before: Amorepacific Corporation |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |