CN101700253B - Probiotic tablet and preparation method thereof - Google Patents
Probiotic tablet and preparation method thereof Download PDFInfo
- Publication number
- CN101700253B CN101700253B CN2009102538728A CN200910253872A CN101700253B CN 101700253 B CN101700253 B CN 101700253B CN 2009102538728 A CN2009102538728 A CN 2009102538728A CN 200910253872 A CN200910253872 A CN 200910253872A CN 101700253 B CN101700253 B CN 101700253B
- Authority
- CN
- China
- Prior art keywords
- probiotic
- parts
- mixed
- tablet
- granule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a manufacturing method and a probiotic tablet with high living bacterium survival rate manufactured by applying the method; the manufacturing method is as follows: applying a dry method pelleting technique and a tabletting technique and taking auxiliary materials such as glucose, lactin, microcrystalline cellulose and the like as raw material to prepare particles, and then blending active ingredient probiotic powder and magnesium stearate to carry out tabletting, and finally obtaining the probiotic tablet. The invention has the advantages that the probiotic tablet is convenient to take and absorb and has obvious treatment effect owing to the high probiotic survival rate; the dry method pelleting technology provided by the invention has the advantages of low cost, fast discharging speed, stable technological conditions, good recurrence and high probiotic survival rate and is suitable for large-scale production.
Description
Technical field:
The invention belongs to technical field of medicine, relate in particular to a kind of probiotic tablet of using the preparation of non-slurry pelletizing technology and preparation method thereof.
Background technology:
Probiotic tablet is a kind of microbial ecological agent; Can regulate the balance of human body intestinal canal flora; Reside in the growth that the interior probiotic bacteria of human body intestinal canal can suppress pathogenic microorganism such as Salmonella etc. in harmful microorganism and the food, probiotic bacteria is brought into play effect through the receptor and the human body immunity improving power that produce acid, bacteriocin and competition intestinal mucosa in intestinal.Probiotic tablet can be used for treatment diarrhoea, and symptoms such as constipation also have the effect that keeps healthy, and its active active ingredient is the live probiotics powder, and wherein common probiotic bacteria comprises bifidobacterium longum, Lactobacillus bulgaricus, streptococcus thermophilus, bacillus acidophilus etc.
Probiotic tablet normally makes through the direct powder compression technology.But shortcoming such as direct powder compression exists, and powder flowbility is poor, poor compressibility, viable bacteria survival rate are low.
Summary of the invention:
One object of the present invention is to provide a kind of probiotic tablet, and because of its viable bacteria survival rate is high, taking convenience is convenient to absorb, and therapeutic effect is obvious.
Another object of the present invention is to provide a kind of non-slurry pelletizing technology; Solved the directly problem of pelletize of shortcomings such as mobile poor, poor compressibility of direct powder compression and viable bacteria survival rate are low and probiotic bacteria powder, advantage such as that this method has is practical, stable technology, cost are lower, be produced on a large scale.
First purpose of the present invention is implemented by following technical scheme: use non-slurry pelletizing technology and pressed-disc technique; With adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder is the feedstock production granule; Remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Another object of the present invention is implemented by following technical scheme:
A kind of probiotic tablet method for preparing may further comprise the steps:
(1) preparation pharmaceutic adjuvant: following component is prepared by weight, wherein glucose 20-40 part, lactose 20-40 part, microcrystalline Cellulose 10-30 part, defatted milk powder 10-30 part, carboxymethyl starch sodium 5-15 part, sucrose 1-10 part, citric acid 1-10 part, magnesium stearate 0.01-1 part;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 10-120 purpose granule and be used for raw materials mix;
(3) raw materials mix: with prepared said granule and probiotic bacteria powder by 10-500: 1 weight ratio is mixed, and by the percentage by weight 0.01-1% adding magnesium stearate of mixed said granule with the probiotic bacteria powder, obtains the raw material of directly compressible after the mixing.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 10-40kn, obtains probiotic tablet.
A kind of probiotic tablet method for preparing; The pharmaceutic adjuvant preparation preferred version of said step (1) is: following component is prepared by weight, wherein glucose 25-35 part, lactose 25-35 part, microcrystalline Cellulose 10-20 part, defatted milk powder 10-20 part, carboxymethyl starch sodium 5-10 part, sucrose 1-5 part, citric acid 1-5 part, magnesium stearate 0.01-0.5 part.
A kind of probiotic tablet method for preparing; The pharmaceutic adjuvant of said step (1) is prepared most preferably, and scheme is: following component is prepared by weight, wherein 25 parts of glucoses, 16.5 parts of lactose, 21 parts of microcrystalline Cellulose, 15 parts of defatted milk powder, 12.5 parts of carboxymethyl starch sodium, 5 parts of sucrose, 5 parts of citric acids, 0.01 part of magnesium stearate.
A kind of probiotic tablet method for preparing, the non-slurry pelletizing preferred version of said step (2) is: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 10-60 purpose granule and be used for raw materials mix.
A kind of probiotic tablet method for preparing; Said step (3) raw materials mix preferred version is: with prepared said granule and probiotic bacteria powder by 10-200: 1 weight ratio is mixed; Ratio in the percentage by weight 0.01-1% of mixed said granule and probiotic bacteria powder adds magnesium stearate, obtains the raw material of directly compressible after the mixing.
A kind of probiotic tablet method for preparing, said step (4) tabletting preferred version is: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 20--40kn, obtains probiotic tablet.
The invention has the advantages that provides a kind of probiotic tablet through the preparation of non-slurry pelletizing technology; This probiotic tablet is high because of its viable bacteria survival rate; Taking convenience is convenient to absorb, and therapeutic effect is obvious; And non-slurry pelletizing technology provided by the invention has, and cost is low, discharging speed is fast, stable process conditions, favorable reproducibility, probiotic bacteria survival rate advantages of higher, is fit to large-scale production.
The specific embodiment:
Embodiment 1:
Using non-slurry pelletizing technology and pressed-disc technique, is the feedstock production granule with adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder, and remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Its production method may further comprise the steps:
(1) preparation pharmaceutic adjuvant: prepare by weight, wherein 20 parts of glucoses, 40 parts of lactose, 10 parts of microcrystalline Cellulose, 10 parts of defatted milk powder, 5 parts of carboxymethyl starch sodium, 1 part of sucrose, 1 part of citric acid, 0.01 part of magnesium stearate;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 10-60 purpose granule and be used for raw materials mix;
(3) raw materials mix: prepared said granule is mixed by 10: 1 weight ratio with the probiotic bacteria powder, add magnesium stearate, obtain the raw material of directly compressible after the mixing in the ratio of the percentage by weight 0.01% of mixed said granule and probiotic bacteria powder.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 10kn, obtains probiotic tablet.
Embodiment 2:
Using non-slurry pelletizing technology and pressed-disc technique, is the feedstock production granule with adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder, and remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Its production method may further comprise the steps:
(1) preparation pharmaceutic adjuvant: prepare by weight, wherein 40 parts of glucoses, 20 parts of lactose, 30 parts of microcrystalline Cellulose, 30 parts of defatted milk powder, 15 parts of carboxymethyl starch sodium, 10 parts of sucrose, 10 parts of citric acids, 1 part of magnesium stearate;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 60-120 purpose granule and be used for raw materials mix;
(3) raw materials mix: prepared said granule is mixed by 500: 1 weight ratio with the probiotic bacteria powder, add magnesium stearate, obtain the raw material of directly compressible after the mixing in the ratio of the percentage by weight 1% of mixed said granule and probiotic bacteria powder.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 40kn, obtains probiotic tablet.
Embodiment 3:
Using non-slurry pelletizing technology and pressed-disc technique, is the feedstock production granule with adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder, and remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Its production method may further comprise the steps:
(1) preparation pharmaceutic adjuvant: prepare by weight, wherein 25 parts of glucoses, 25 parts of lactose, 20 parts of microcrystalline Cellulose, 20 parts of defatted milk powder, 10 parts of carboxymethyl starch sodium, 5 parts of sucrose, 5 parts of citric acids, 0.5 part of magnesium stearate;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 10-30 purpose granule and be used for raw materials mix;
(3) raw materials mix: prepared said granule is mixed by 200: 1 weight ratio with the probiotic bacteria powder, add magnesium stearate, obtain the raw material of directly compressible after the mixing in the ratio of the percentage by weight 0.01% of mixed said granule and probiotic bacteria powder.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 20kn, obtains probiotic tablet.
Embodiment 4:
Using non-slurry pelletizing technology and pressed-disc technique, is the feedstock production granule with adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder, and remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Its production method may further comprise the steps:
(1) preparation pharmaceutic adjuvant: prepare by weight, wherein 35 parts of glucoses, 35 parts of lactose, 10 parts of microcrystalline Cellulose, 10 parts of defatted milk powder, 5 parts of carboxymethyl starch sodium, 1 part of sucrose, 1 part of citric acid, 0.01 part of magnesium stearate;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 30-60 purpose granule and be used for raw materials mix;
(3) raw materials mix: prepared said granule is mixed by 100: 1 weight ratio with the probiotic bacteria powder, add magnesium stearate, obtain the raw material of directly compressible after the mixing in the ratio of the percentage by weight 1% of mixed said granule and probiotic bacteria powder.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 40kn, obtains probiotic tablet.
Embodiment 5:
Using non-slurry pelletizing technology and pressed-disc technique, is the feedstock production granule with adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder, and remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Its production method may further comprise the steps:
(1) preparation pharmaceutic adjuvant: prepare by weight, wherein 30 parts of glucoses, 30 parts of lactose, 15 parts of microcrystalline Cellulose, 15 parts of defatted milk powder, 7 parts of carboxymethyl starch sodium, 3 parts of sucrose, 3 parts of citric acids, 0.25 part of magnesium stearate;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 20-50 purpose granule and be used for raw materials mix;
(3) raw materials mix: prepared said granule is mixed by 350: 1 weight ratio with the probiotic bacteria powder, add magnesium stearate, obtain the raw material of directly compressible after the mixing in the ratio of the percentage by weight 0.5% of mixed said granule and probiotic bacteria powder.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 30kn, obtains probiotic tablet.
Embodiment 6:
Using non-slurry pelletizing technology and pressed-disc technique, is the feedstock production granule with adjuvants such as glucose, lactose, microcrystalline Cellulose, defatted milk powder, and remix active ingredient probiotic bacteria powder and magnesium stearate are carried out tabletting, finally obtain probiotic tablet.
Its production method may further comprise the steps:
(1) preparation pharmaceutic adjuvant: prepare by weight, wherein 25 parts of glucoses, 16.5 parts of lactose, 21 parts of microcrystalline Cellulose, 15 parts of defatted milk powder, 12.5 parts of carboxymethyl starch sodium, 5 parts of sucrose, 5 parts of citric acids, 0.01 part of magnesium stearate;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 20-30 purpose granule and be used for raw materials mix;
(3) raw materials mix: prepared said granule is mixed by 19: 1 weight ratio with the probiotic bacteria powder, add magnesium stearate, obtain the raw material of directly compressible after the mixing in the ratio of the percentage by weight 0.1% of mixed said granule and probiotic bacteria powder.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 18kn, obtains probiotic tablet.
Embodiment 7: the probiotic tablet that is obtained according to the embodiment 1-6 experimental data of comparing with the probiotic tablet that conventional method is obtained is following:
1, tablet quality detects
2, probiotic tablet is preserved the survival rate detection
With probiotic tablet airtight preservation under 25 ℃ temperature that embodiment 1--6 gained preparation and conventional method are obtained, place behind the different time according to conventional method and detect in the preparation viable count and calculate survival rate, the result is following:
Through above-mentioned experimental data, show the probiotic tablet of the disclosed non-slurry pelletizing of the present invention technology and preparation thereof, compare with the probiotic tablet of traditional method and preparation, have direct compression good fluidity, compressibility is good, the viable bacteria survival rate is high advantage.
Claims (7)
1. probiotic tablet method for preparing is characterized in that may further comprise the steps:
(1) preparation pharmaceutic adjuvant: following component is prepared by weight, wherein glucose 20-40 part, lactose 20-40 part, microcrystalline Cellulose 10-30 part, defatted milk powder 10-30 part, carboxymethyl starch sodium 5-15 part, sucrose 1-10 part, citric acid 1-10 part, magnesium stearate 0.01-1 part;
(2) non-slurry pelletizing: pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 10-120 purpose granule and be used for raw materials mix;
(3) raw materials mix: with prepared said granule and probiotic bacteria powder by 10-500: 1 weight ratio is mixed; Ratio in the percentage ratio 0.01-1% of mixed said granule and probiotic bacteria powder weight sum adds magnesium stearate, obtains the raw material of directly compressible after the mixing.
(4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 10--40kn, obtains probiotic tablet.
2. a kind of probiotic tablet method for preparing according to claim 1; It is characterized in that; The pharmaceutic adjuvant preparation of said step (1): following component is prepared by weight, wherein glucose 25-35 part, lactose 25-35 part, microcrystalline Cellulose 10-20 part, defatted milk powder 10-20 part, carboxymethyl starch sodium 5-10 part, sucrose 1-5 part, citric acid 1-5 part, magnesium stearate 0.01-0.5 part.
3. a kind of probiotic tablet method for preparing according to claim 1; It is characterized in that; The pharmaceutic adjuvant preparation of said step (1): following component is prepared by weight, wherein 25 parts of glucoses, 16.5 parts of lactose, 21 parts of microcrystalline Cellulose, 15 parts of defatted milk powder, 12.5 parts of carboxymethyl starch sodium, 5 parts of sucrose, 5 parts of citric acids, 0.01 part of magnesium stearate.
4. a kind of probiotic tablet method for preparing according to claim 1 is characterized in that, the non-slurry pelletizing of said step (2): pharmaceutic adjuvant is mixed the back add the pelletize of non-slurry pelletizing machine, collect 10-60 purpose granule and be used for raw materials mix.
5. a kind of probiotic tablet method for preparing according to claim 1; It is characterized in that; Said step (3) raw materials mix: with prepared said granule and probiotic bacteria powder by 10-200: 1 weight ratio is mixed; Ratio in the percentage by weight 0.01-1% of mixed said granule and probiotic bacteria powder adds magnesium stearate, obtains the raw material of directly compressible after the mixing.
6. a kind of probiotic tablet method for preparing according to claim 1 is characterized in that, said step (4) tabletting: raw materials mixed is dropped into the tablet machine tabletting, and adjusting pressure is 20--40kn, obtains probiotic tablet.
7. the probiotic tablet for preparing according to the arbitrary said method of claim 1 to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102538728A CN101700253B (en) | 2009-12-03 | 2009-12-03 | Probiotic tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102538728A CN101700253B (en) | 2009-12-03 | 2009-12-03 | Probiotic tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101700253A CN101700253A (en) | 2010-05-05 |
| CN101700253B true CN101700253B (en) | 2012-04-18 |
Family
ID=42155196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102538728A Active CN101700253B (en) | 2009-12-03 | 2009-12-03 | Probiotic tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101700253B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843337B (en) * | 2010-06-07 | 2012-10-10 | 陕西科技大学 | Method for preparing probiotics tablets |
| CN104082744A (en) * | 2014-07-09 | 2014-10-08 | 任发政 | Probiotics dispersible tablets and preparation method thereof |
| CN104305168A (en) * | 2014-07-29 | 2015-01-28 | 吉林农业大学 | A preparing method of lactobacillus rhamnosus particle food relieving alcoholic liver injury |
| CN105963326A (en) * | 2016-06-13 | 2016-09-28 | 合肥赛为智慧医疗有限公司 | Preparation method of probiotics and dunaliella salina tablets |
| CN106579457A (en) * | 2016-12-30 | 2017-04-26 | 天津替代医学科技股份有限公司 | Butyric acid bacterium probiotic acid slice and preparation method thereof |
| CN108018211B (en) * | 2018-02-06 | 2021-08-13 | 内蒙古双奇药业股份有限公司 | Culture medium for improving freezing tolerance of lactobacillus bulgaricus and application method thereof |
| CN109480070A (en) * | 2018-12-29 | 2019-03-19 | 广东省农业科学院农业生物基因研究中心 | A kind of feeding probiotic granulate preparation and preparation method thereof |
| CN110882281B (en) * | 2019-11-30 | 2023-01-10 | 江苏艾兰得营养品有限公司 | Probiotic enteric-coated tablet and preparation method thereof |
| CN110960560B (en) * | 2019-12-09 | 2021-08-20 | 上海交大昂立股份有限公司 | Tablet with high probiotic activity and preparation method and application thereof |
| CN114304643A (en) * | 2022-01-14 | 2022-04-12 | 微康益生菌(苏州)股份有限公司 | Probiotic tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1766095A (en) * | 2005-09-16 | 2006-05-03 | 保罗生物园科技有限公司 | Probiotic composite enzyme production method |
-
2009
- 2009-12-03 CN CN2009102538728A patent/CN101700253B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1766095A (en) * | 2005-09-16 | 2006-05-03 | 保罗生物园科技有限公司 | Probiotic composite enzyme production method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101700253A (en) | 2010-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101700253B (en) | Probiotic tablet and preparation method thereof | |
| RU2587717C2 (en) | Effervescent composition in solid form for use in vaginal applications for treating vaginal infections | |
| US10793925B2 (en) | Lactobacillus paracasei for the production of conjugated linoleic acid, nutritional and pharmaceutical preparations containing it and uses thereof | |
| CN104957633B (en) | Plant enzyme solid pharmaceutical preparation and preparation method thereof | |
| JPWO2005092122A1 (en) | Composition comprising yucca extract, kiraya extract and lactic acid bacteria, and food and drink containing the composition | |
| CN107279649A (en) | A kind of probiotics solid beverage formula and its manufacture method | |
| CN102258082A (en) | Coagulating probiotic goat yoghurt and preparation method thereof | |
| JP6039638B2 (en) | Adiponectin secretion promoter and / or suppressor | |
| US20130309212A1 (en) | Lactobacillus salivarius and method for preparing metabolite thereof, composition of lactobacillus salivarius and metabolite thereof and use of the composition | |
| WO2014117679A1 (en) | High-dosage bacillus licheniformis viable bacteria composition and preparation method and use thereof | |
| EP3092320B1 (en) | New strains of the genus lactobacillus and use thereof | |
| JP5415232B2 (en) | Production method of viable bacteria preparation | |
| KR101595014B1 (en) | Method of fermented milk using lactobacillus | |
| JP2008043206A (en) | Orally-ingested solid composition, and method for producing the same | |
| JP6074799B2 (en) | Lactic acid bacteria growth promoter and yogurt containing the same | |
| CN105638879A (en) | Effervescent tablet starter for self-made yoghourt | |
| CN111657386A (en) | Preparation method of probiotic tabletting candy | |
| JP2001169749A (en) | Live bacterium composition | |
| CN103937718B (en) | Soya-bean milk streptococcus, soy yogurt leavening and application thereof | |
| CN101768557A (en) | Probiotic bacteria culture medium and microbial agent | |
| JP5873904B1 (en) | Composition for improving restless legs syndrome | |
| CN114762527B (en) | Tasty and refreshing tablet containing active probiotics and preparation method thereof | |
| CN114916607B (en) | Tablet candy containing probiotics, preparation and packaging method thereof | |
| CN113854388B (en) | Probiotic pressed candy containing undaria pinnatifida polysaccharide fermentation product and preparation method thereof | |
| JP5980785B2 (en) | New bifidobacteria and their use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |