CN109480070A - A kind of feeding probiotic granulate preparation and preparation method thereof - Google Patents
A kind of feeding probiotic granulate preparation and preparation method thereof Download PDFInfo
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- CN109480070A CN109480070A CN201811634926.0A CN201811634926A CN109480070A CN 109480070 A CN109480070 A CN 109480070A CN 201811634926 A CN201811634926 A CN 201811634926A CN 109480070 A CN109480070 A CN 109480070A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
Abstract
The present invention discloses a kind of feeding probiotic granulate preparation and preparation method thereof, belongs to feeding probiotics manufacture field.The granular preparation includes being made of following components in parts by weight: 5~20 parts of probiotic powder, 5~40 parts of probiotics nutritional agents, 10~20 parts of acid-base modifier, 10~40 parts of disintegrating agent, 0~10 part of gel excipients, 5~15 parts of adhesive, 0~20 part of filler, 0.1~0.5 part of lubricant.Probiotic granulate preparation of the invention can reduce probiotic cell and extraneous contact area in particle, improve probiotic granulate storage stability.In addition, granular preparation can slow down thermal conduction rate, survival rate of the probiotics under feed granulating hot conditions is improved.Granulation technique provided by the invention is at low cost, discharge fast, process stabilizing, high repeatability and other advantages, suitable large-scale production.
Description
Technical field
The invention belongs to feeding probiotics manufacture fields, and in particular to a kind of feeding probiotic granulate preparation and its preparation side
Method.
Background technique
Feedstuff industry for a long time largely using antibiotics growth accelerator bring drug resistance, environmental pollution, medicament residue and
The problems such as food safety, constitutes potential threat to human health.The states such as America and Europe have started to disable feeding antibiotic comprehensively.With
Beginning of the year Ministry of Agriculture bulletin forbids the anti-order of the limit further upgrading in food animal using veterinary drugs such as olaquindoxes, disables comprehensively feeding
Antibiotic has been trend of the times.Currently, both at home and abroad in generally acknowledged feed Substitutes For Antibiotic include probiotics, antibacterial peptide,
6 major class such as enzyme preparation, Chinese herbal medicine, plant extracts and acidulant.Probiotics (probiotics) is adjusting gastrointestinol microorganism
The balance of fauna, improve breeding performonce fo animals in terms of play a significant role, it is considered to be after antibiotic epoch ideal substitute it
One.The feeding probiotics that domestic approval uses at present mainly includes the kinds such as bacillus category, yeast class and lactic acid bacteria class, wherein
Lactic acid bacteria class probiotics domestic at present is mostly freeze-dried type pulvis.Feeding micro-ecological preparation requires have preferable storage stability, together
When be resistant to the particular surroundings such as feed granulating process high temperature, high pressure, high humidity.And lactic acid bacteria class probiotics is due to big portion
Divide kind Strain comparison fragile, it is difficult to long-term storage and tolerance feed granulating hot environment, thus use is extremely restricted.?
Grain feed and after expanded pellet diet adds Tiny ecosystem pulvis in process can be caused under the condition of high temperature and high humidity 90% with epigaster
Coccus inactivation, lactobacillus almost all are killed.
Therefore it need to reinforce the research to lactic acid bacteria class probiotics dosage form, improve viable bacteria concentration, improve living in probiotics preparation
Bacterium extends product storage life to the tolerance of poor environment.Probiotics dosage form mainly has tablet, pulvis and microcapsules at present
The different types such as grain preparation.Feeding probiotics preparation is mostly based on pulvis and granular preparation, and tablet greatly can not very much due to particle
Applied to feed processing industry.Lactobacillus etc probiotics is generally more delicate, is exposed in air and is easy inactivation.Opposite pulvis
For, material specific surface area can be greatly decreased in granular preparation, reduce material and air, contact with moisture area, product can be improved
Keeping quality energy.In addition, granular preparation can slow down heat to transmitting inside particle, active bacteria formulation is improved under the conditions of high temperature granulating
Survival rate.The features such as easy in inactivation such as lactobacillus, the measure for solving feeding lactobacillus easy in inactivation include that can use particle packet
It buries technology to embed viable bacteria body, forms granular preparation, completely cut off most cells and extraneous poor environment, to improve cell
Survival rate.The lactic acid bacterium particle preparation prepared at present by microcapsules mode the problems such as there are complex process, higher cost, greatly
Limit the application of livestock and poultry cultivation industry.Therefore prepare that a kind of viable count is high, easily storage, processing technology are simple, facilitates application
Feeding probiotics preparation is that industry faces the challenge.
Summary of the invention
The shortcomings that in order to overcome existing feeding probiotic products dosage form and deficiency, the primary purpose of the present invention is that providing one
The feeding probiotic granulate preparation of kind.
Another object of the present invention is to provide a kind of preparation methods of feeding probiotic granulate preparation.
Feeding probiotic granulate preparation provided by the invention and preparation method thereof is resistant in feed granulating process high
Warm high humidity environment improves probiotics preparation resistant storage properties energy and its survival rate in feed processing.
The purpose of the invention is achieved by the following technical solution:
A kind of feeding probiotic granulate preparation, including be made of following components in parts by weight:
5~20 parts of probiotic powder, 5~40 parts of probiotics nutritional agents, 10~20 parts of acid-base modifier, disintegrating agent 10~40
Part, 0~10 part of gel excipients, 5~15 parts of adhesive, 0~20 part of filler, 0.1~0.5 part of lubricant；
Preferably, including by following components in parts by weight it is made:
10~15 parts of probiotic powder, 20~25 parts of probiotics nutritional agents, 10~20 parts of acid-base modifier, disintegrating agent 15~25
Part, 2~3 parts of gel excipients, 10 parts of adhesive, 15~20 parts of filler, 0.5 part of lubricant；
It is furthermore preferred that including being made of following components in parts by weight:
10~15 parts of probiotic powder, 20~25 parts of probiotics nutritional agents, 11.5~16.5 parts of acid-base modifier, disintegrating agent 15
~25 parts, 3 parts of gel excipients, 10 parts of adhesive, 15~20 parts of filler, 0.5 part of lubricant；
Preferably, the probiotics nutritional agents is in glucose, lactose, skimmed milk power, oligofructose or xylo-oligosaccharide
One or more combinations, for providing nutrition after recovering to rest cell in dry powder；Wherein, lactose can also play certain glue
Cooperation is used, and glucose, skimmed milk power may also function as filling effect.
Preferred into one, the probiotics nutritional agents is glucose and lactose；
Preferably, the acid-base modifier is calcium carbonate etc., for adjusting swellable particles in acid condition in particle
Portion's pH value, part of calcium carbonate can also be substituted with sodium bicarbonate.Wherein, calcium carbonate may also function as filling effect.
Preferably, the disintegrating agent is microcrystalline cellulose etc., and microcrystalline cellulose is mainly as disintegrating agent.Wherein crystallite is fine
Dimension element may also function as filling effect.
Preferably, the gel excipients are sodium carboxymethylcellulose etc., and sodium carboxymethylcellulose is as particulate water absorbent
Gel excipients are formed, certain thickening power can also be played.
Preferably, the adhesive is dextrin etc., as adhesive during dry granulation.
Preferably, the dextrin is maltodextrin；
Preferably, the filler is starch, calcium monohydrogen phosphate etc.；Starch, calcium monohydrogen phosphate are mainly as filler.
Preferably, the lubricant is magnesium stearate etc..
It is further preferred that the feeding probiotic granulate preparation, including be made of following components in parts by weight:
10~15 parts of probiotic powder, 10~15 parts of glucose, 5~10 parts of lactose, 10~20 parts of calcium carbonate, microcrystalline cellulose
15~25 parts, 3 parts of sodium carboxymethylcellulose, 10 parts of maltodextrin, 15~20 parts of starch, 0.5 part of magnesium stearate；
Most preferably, the feeding probiotic granulate preparation, including be made of following components in parts by weight:
10~15 parts of probiotic powder, 10~15 parts of glucose, 10 parts of lactose, 11.5~16.5 parts of calcium carbonate, microcrystalline cellulose
Plain 15~25 parts, 3 parts of sodium carboxymethylcellulose, 10 parts of maltodextrin, 15~20 parts of starch, 0.5 part of magnesium stearate；
Preferably, the viable count in the probiotic powder is 1000~200,000,000,000/g；More preferably 100,000,000,000/g.
Preferably, the probiotic powder is lactic acid bacteria bacterium powder；The probiotic powder can be single lactobacillus original powder,
It can also be several lactobacillus original powder mixtures.The probiotics original powder be by for after single lactobacillus-fermented by freeze-drying, spray
Mist is dry or other approach obtain pulvis.
It is furthermore preferred that the probiotic powder is at least one in lactobacillus reuteri bacterium powder and lactobacillus plantarum bacterium powder
Kind.
The preparation method of the feeding probiotic granulate preparation, includes the following steps:
Probiotics nutritional agents, acid-base modifier, disintegrating agent, partial gel excipients, adhesive, filler are mixed equal
It is even, granules of accessories is made into using dry granulation technology, then by granules of accessories, probiotic powder, remaining gel excipients and profit
Lubrication prescription is sufficiently mixed uniformly, then probiotic tablet is made in powder, is then crushed dry probiotic tablet, screening retention diameter
For the particle of 1.0~2.5mm, as feeding probiotic granulate preparation.
Preferably, refer to using dry granulation technology and be granulated with dry granulating machine machine.
The granules of accessories is 20~80 mesh particles；Preferably 20~60 mesh particles；More preferably 20~40 mesh particles.
Preferably, the mass ratio of partial gel excipients and remaining gel excipients is 1:2.
Preferably, probiotic tablet is made and refers to that carrying out tabletting with tablet press machine is made probiotic tablet.
It is 15~40KN that pressure used in probiotic tablet, which is made,；Preferably 20~30KN.
Preferably, it is described it is broken be to be crushed using crusher.
Preferably, the particle that screening retention diameter is 1.5~2.5mm.
Being used as tabletting raw material less than 1mm particle, probiotic tablet is made in tabletting again.
The present invention has the following advantages and effects with respect to the prior art:
The present invention provides a kind of simple process to prepare feeding probiotic granulate preparation, the granular preparation Viable detection
Height, it is easy to use.The probiotic granulate preparation that the present invention is prepared can be swollen first when meeting water becomes gel particle,
Under gastrointestinal tract acid condition the substances such as intragranular calcium carbonate can in and penetrate into acid ion inside particle, for lactic acid bacteria recover
Control environment is provided, nutrition can be provided in time after the dissolution of the nutritional agents such as lactose, glucose in swellable particles for recovery lactic acid bacteria, just
In raising lactic acid bacteria survival rate in gastrointestinal tract.The probiotic granulate preparation that the present invention is prepared can reduce prebiotic in particle
Bacterium cell and extraneous contact area, improve probiotic granulate storage stability.In addition, granular preparation can slow down thermal conduction rate,
Improve survival rate of the probiotics under feed granulating hot conditions.Granulation technique provided by the invention have at low cost, discharging is fast,
Process stabilizing, high repeatability and other advantages are suitble to large-scale production.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
The test method of specific experiment condition is not specified in the following example, usually according to conventional laboratory conditions or according to system
Make experiment condition proposed by factory.Used material, reagent etc., unless otherwise specified, for the reagent obtained from commercial channels
And material.
Lactobacillus reuteri as described in the examples is can be feeding in " catalogue of feed additive varieties " of Ministry of Agriculture's promulgation
Lactobacillus reuteri；Including Lactobacillus reuteri LR1 bacterial strain.Wherein, Lactobacillus reuteri
LR1 is disclosed in patent " 201510751130.3, one plants of L. reuteri strains and its application with prebiotic characteristics ".Institute
The lactobacillus plantarum stated is lactobacillus plantarum that can be feeding in " catalogue of feed additive varieties " of Ministry of Agriculture's promulgation.Embodiment 2
Used in lactobacillus plantarum be 1258 bacterial strain of Lactobacillus.plantarum CGMCC.
A kind of preparation of feeding lactobacillus reuteri granular preparation of embodiment 1
A kind of preparation method of feeding lactobacillus reuteri granular preparation, includes the following steps:
(1) 10 parts of glucose, 10 parts of lactose, 20 parts of starch, 10 parts of maltodextrin, calcium carbonate 16.5 auxiliaries: are weighed
Part, 1 part of sodium carboxymethylcellulose and 15 parts of microcrystalline cellulose are used as auxiliary material, and auxiliary material is sufficiently mixed and is uniformly added into dry granulating machine
It is granulated, collects 20~40 mesh particles and be used as subsequent tabletting raw material.
(2) 82.5 parts of granulate excipients, 15 parts of freeze-drying lactobacillus reuteri original powder (viable count is 100,000,000,000/g), carboxylic first are weighed
2 parts of base sodium cellulosate, 0.5 part of magnesium stearate are sufficiently mixed uniformly.
(3) raw material investment tablet press machine will be mixed and carry out tabletting, pressure 20KN is adjusted, obtain probiotic tablet；
(4) probiotic tablet is crushed using crusher, 1.5~2.5mm particle, vacuum sealing packet are collected in screening
Dress.
A kind of preparation of feeding compound lactobacillus granular preparation of embodiment 2
A kind of preparation method of feeding compound lactobacillus granular preparation, includes the following steps:
(1) 15 parts of glucose, 10 parts of lactose, 15 parts of starch, 10 parts of maltodextrin, calcium carbonate 11.5 auxiliaries: are weighed
Part, 1 part of sodium carboxymethylcellulose and 25 parts of microcrystalline cellulose are used as auxiliary material, and auxiliary material is sufficiently mixed and is uniformly added into dry granulating machine
It is granulated, collects 20~40 mesh particles and be used as subsequent tabletting raw material.
(2) 87.5 parts of granulate excipients, lactobacillus reuteri (viable count is 100,000,000,000/g) and lactobacillus plantarum original powder are weighed
(viable count is 100,000,000,000/g) 10 parts of equal proportion Mixed Microbes powder, 2 parts of sodium carboxymethylcellulose, is sufficiently mixed by 0.5 part of magnesium stearate
Uniformly.
(3) raw material investment tablet press machine will be mixed and carry out tabletting, pressure 30KN is adjusted, obtain compound probiotic tablet
(4) compound probiotic tablet is crushed using crusher, 1.5~2.5mm particle, vacuum sealing are collected in screening
Packaging.
The detection of 3 feeding lactobacillus granular preparation of embodiment
The granular preparation for weighing the preparation of 1.0g embodiment 1 is dissolved into 100mL sterile saline, and mixing fullys shake,
Then be diluted to suitable concentration using 10 times of dilution methods, be coated with MRS plate later and carry out count plate, using original bacteria original powder as
It compares, Lactobacillus Survival is 60~65% in granular preparation.
The obtained granular preparation of embodiment 1 and bacterium original powder are sealed in indoor shady place, divided after placing a period of time
Not Ce viable count, be shown in Table 1.
Table 1
The granular preparation for taking a certain amount of lactobacillus reuteri original powder and embodiment 1 to prepare is respectively implanted simulated gastric fluid and (takes
Dilute hydrochloric acid (taking concentrated hydrochloric acid 234mL, be diluted with water to 1000mL and be made) 16.4mL, adds water about 800mL and pepsin 10g, shakes
After even, be diluted with water into 1000mL to get.) in infiltrate 60min, then concussion shake up, later carry out 10 times of gradient dilutions, choosing
Appropriate dilution is taken to carry out count plate using MRS plate, using original viable count as control, as a result, it has been found that bacterium original powder survival rate
It is 64%, and granular preparation survival rate is 81%.
For the above results show that probiotic granulate preparation prepared by the present invention compares traditional pulvis, have preferably resistance to
Storage property and resistance.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of feeding probiotic granulate preparation, it is characterised in that: including being made of following components in parts by weight:
5~20 portions of probiotic powder, 10~20 parts of acid-base modifier, 10~40 parts of disintegrating agent, coagulates at 5~40 parts of probiotics nutritional agents
0~10 part of glue excipients, 5~15 parts of adhesive, 0~20 part of filler, 0.1~0.5 part of lubricant.
2. feeding probiotic granulate preparation according to claim 1, it is characterised in that: including by parts by mass
Component is made:
10~15 parts of probiotic powder, 20~25 parts of probiotics nutritional agents, 10~20 parts of acid-base modifier, 15~25 parts of disintegrating agent,
2~3 parts of gel excipients, 10 parts of adhesive, 15~20 parts of filler, 0.5 part of lubricant.
3. feeding probiotic granulate preparation according to claim 1 or 2, it is characterised in that:
The probiotics nutritional agents is one or more groups in glucose, lactose, skimmed milk power, oligofructose or xylo-oligosaccharide
It closes；
The acid-base modifier is calcium carbonate or sodium bicarbonate；
The disintegrating agent is microcrystalline cellulose；
The gel excipients are sodium carboxymethylcellulose；
The adhesive is dextrin；
The filler is starch or calcium monohydrogen phosphate；
The lubricant is magnesium stearate.
4. feeding probiotic granulate preparation according to claim 3, it is characterised in that:
The probiotics nutritional agents is glucose and lactose；
The dextrin is maltodextrin.
5. feeding probiotic granulate preparation according to claim 4, it is characterised in that: including by parts by mass
Component is made:
10~15 parts of probiotic powder, 10~15 parts of glucose, 5~10 parts of lactose, 10~20 parts of calcium carbonate, microcrystalline cellulose 15~
25 parts, 3 parts of sodium carboxymethylcellulose, 10 parts of maltodextrin, 15~20 parts of starch, 0.5 part of magnesium stearate.
6. feeding probiotic granulate preparation according to claim 5, it is characterised in that:
Viable count in the probiotic powder is 1000~200,000,000,000/g.
7. feeding probiotic granulate preparation according to claim 6, it is characterised in that:
The probiotic powder is lactic acid bacteria bacterium powder.
8. feeding probiotic granulate preparation according to claim 7, it is characterised in that:
The probiotic powder is at least one of lactobacillus reuteri bacterium powder and lactobacillus plantarum bacterium powder.
9. the preparation method of feeding probiotic granulate preparation according to any one of claims 1 to 8, it is characterised in that: including such as
Lower step:
Probiotics nutritional agents, acid-base modifier, disintegrating agent, partial gel excipients, adhesive, filler are uniformly mixed, answered
It is made into granules of accessories with dry granulation technology, then granules of accessories, probiotic powder, remaining gel excipients and lubricant are filled
Divide and be uniformly mixed, then probiotic tablet is made in powder, be then crushed dry probiotic tablet, screening retention diameter is 1.0
The particle of~2.5mm, as feeding probiotic granulate preparation.
10. the preparation method of feeding probiotic granulate preparation according to claim 9, it is characterised in that:
The granules of accessories is 20~80 mesh particles；
The mass ratio of partial gel excipients and remaining gel excipients is 1:2；
It is 15~40KN that pressure used in probiotic tablet, which is made,；
The particle that screening retention diameter is 1.5~2.5mm.
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| CN201811634926.0A CN109480070A (en) | 2018-12-29 | 2018-12-29 | A kind of feeding probiotic granulate preparation and preparation method thereof |
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| CN201811634926.0A CN109480070A (en) | 2018-12-29 | 2018-12-29 | A kind of feeding probiotic granulate preparation and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110960560A (en) * | 2019-12-09 | 2020-04-07 | 上海交大昂立股份有限公司 | Tablet with high probiotic activity and preparation method and application thereof |
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