CN101692999A - Mouth wash containing grape pip procyanidin extract and application - Google Patents
Mouth wash containing grape pip procyanidin extract and application Download PDFInfo
- Publication number
- CN101692999A CN101692999A CN200910154055A CN200910154055A CN101692999A CN 101692999 A CN101692999 A CN 101692999A CN 200910154055 A CN200910154055 A CN 200910154055A CN 200910154055 A CN200910154055 A CN 200910154055A CN 101692999 A CN101692999 A CN 101692999A
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- grape pip
- extract
- pip procyanidin
- procyanidin extract
- collutory
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- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 title claims abstract description 43
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 title claims abstract description 43
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 title claims abstract description 43
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 229920002414 procyanidin Polymers 0.000 title claims abstract description 43
- 239000000284 extract Substances 0.000 title claims abstract description 41
- 235000009754 Vitis X bourquina Nutrition 0.000 title claims abstract description 37
- 235000012333 Vitis X labruscana Nutrition 0.000 title claims abstract description 37
- 235000014787 Vitis vinifera Nutrition 0.000 title claims abstract description 37
- 239000002324 mouth wash Substances 0.000 title abstract 5
- 229940051866 mouthwash Drugs 0.000 title abstract 5
- 240000006365 Vitis vinifera Species 0.000 title 1
- 241000219095 Vitis Species 0.000 claims abstract description 42
- 208000002925 dental caries Diseases 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 7
- 201000001245 periodontitis Diseases 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 239000000654 additive Substances 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 7
- 235000009392 Vitis Nutrition 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000000287 crude extract Substances 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000011258 core-shell material Substances 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 210000000214 mouth Anatomy 0.000 abstract description 15
- 230000000474 nursing effect Effects 0.000 abstract 1
- 241000194019 Streptococcus mutans Species 0.000 description 8
- 208000028169 periodontal disease Diseases 0.000 description 7
- 241000700159 Rattus Species 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000036541 health Effects 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 241001026377 Streptococcus sobrinus 6715 Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000024283 Gingival haemorrhages Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 description 1
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000194025 Streptococcus oralis Species 0.000 description 1
- 241000193987 Streptococcus sobrinus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 238000002814 agar dilution Methods 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229940097572 chloromycetin Drugs 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000003845 vascular endothelial function Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention provides mouth wash containing a grape pip procyanidin extract, which is prepared from the grape pip procyanidin extract and a common mouth wash component by a traditional preparation process. The pH value of the mouth wash is 5.5-7.5, wherein the grape pip procyanidin extract accounts for 0.1-30% of the total amount in percent by weight, and the content of procyanidin in the grape pip procyanidin extract is not less than 95%. The provided mouth wash containing the grape pip procyanidin extract is used as a daily health-care nursing product of the oral cavity for daily use, can prevent dental caries and parodontitis and also can be used as an auxiliary treatment medicine for a dentist to treat caries and parodontopathy.
Description
Technical field
The invention belongs to health product, relate to a kind of collutory that contains grape pip procyanidin extract, in the prevention and control of dental caries and periodontal disease and daily mouth care health care technology field, play a role.
Background technology
Collutory is widely used in people's daily life and oral cavity auxiliary treatment as a kind of mouth care health promoting product, have prevention and control dental caries and periodontal disease, diseases such as the common toothache in oral cavity, gingivitis, gingival hemorrhage there is better curative effect, have obvious heat clearing and inflammation relieving, hemostasis, antibacterial, analgesic activity, remove halitosis.
Dental caries and periodontal disease are modal oral diseases, are the emphasis of China's stomatology research to the research of these two kinds of diseases always.The dental caries ecological theory thinks, with dental caries relevant antibacterial being taken place all is the oral cavity normal microflora, under physiological status, between the antibacterial, be in dynamic equilibrium between antibacterial and the host, disease do not take place; Because change partial, whole body, food factor, cause the variation of oral cavity ecological environment, the pathologic combination is changed in physiological combination between normal bacteria and the host, the oral cavity ecological balance is converted into ecological disturbance, normal bacteria becomes conditioned pathogen, cause dental caries, and Streptococcus mutans is the Streptococcus oralis the closest with the dental caries onset relation.
The natural drug source is wide, and toxic and side effects is little, and exploitation and development natural plant are emphasis in present medicine and the food research.Over more than 100 year, Fructus Vitis viniferae is a unfailing research topic in numerous plants always.The fifties so far; people are from grape fruit; leaf separates with other position; the polyphenolic substance of identifying; fatty acid; vitamin; enzyme; carbohydrate; aminoacid; polypeptide and protein; terpenes and volatile oil component and lipid; material such as pectin and wax reaches kind more than 100; among numerous compositions; the medical functions of Fructus Vitis viniferae is mostly relevant with the pharmacologically active of procyanidin; source as procyanidin; grape pip procyanidin extract has obtained the most deeply and widely paying close attention to; manyly both at home and abroad discover that it has multiple important biomolecule activity and pharmacological action; extremely strong antioxidation is arranged and remove free radical activity; can be by the protection vascular endothelial function; the number of mechanisms anti-cardiovascular diseases such as oxidation of anti-myocardium oxidative stress damage and inhibition low density lipoprotein, LDL become the focus of research in recent years.
Germ experiment and animal experiment study find that grape pip procyanidin extract has inhibitory action to Streptococcus mutans.Have the scholar to pass through abroad, and the research of the influence of the expression of the inducible nitric oxide synthase that periodontal disease mouse macrophage lipopolysaccharide is intensified prompting grape pip procyanidin extract can be considered as the drug development of prevention of periodontal disease to the generation of grape pip procyanidin extract to Mus activity in vivo oxygen and active nitrogen.
Summary of the invention
The invention provides a kind of collutory that contains grape pip procyanidin extract, with mixings such as grape pip procyanidin extract and ethanol, medicinal glycerin, natural menthence, additives (flavorant, sweeting agent), deionized waters, it is 5.5～7.5 the light red brown liquid of clear that filtration makes pH value, wherein grape pip procyanidin extract accounts for 0.1%～30% of total amount by weight percentage
Key component ratio by weight is as follows:
Grape pip procyanidin extract 0.1～30%
95% ethanol 0.1～0.4%
Medicinal glycerin 0.5～5%
Natural menthence 0.03～0.2%
Additives (flavorant, sweeting agent) 0.1～0.4%
Deionized water is assigned to 100%.
Grape pip procyanidin extract is to be pulverized by the Semen Vitis viniferae drying, after the core shell separates, with ethanol in shell, extract, filtration, spray drying get crude extract, crude extract through the solvent staging or active carbon adsorption is dry must the bronzing powder.
Another object of the present invention provides the described application of collutory in preparation caries prevention and periodontitis adjuvant therapy medicaments that contains grape pip procyanidin extract.
The present invention effectively utilizes the effective ingredient procyanidin in the Semen Vitis viniferae extract, adopt preparation technology to prepare a kind of collutory that contains grape pip procyanidin extract that the common dental caries in oral cavity and periodontal disease are had the prevention and control effect, can effectively kill Streptococcus mutans, influence the progress of periodontitis, not only can be used for the auxiliary treatment of oral cavity commonly encountered diseases, also can be used for daily oral cavity health.
The specific embodiment
The present invention is further described in conjunction with the embodiments.
Embodiment 1
The preparation that contains the collutory of grape pip procyanidin extract is at first to extract grape pip procyanidin extract, promptly pulverize by the Semen Vitis viniferae drying, after the core shell separates, with ethanol in shell, extract, filtration, spray drying get crude extract, crude extract through solvent staging or active carbon adsorption dry the bronzing powder.Again with mixings such as grape pip procyanidin extract and ethanol, medicinal glycerin, natural menthence, additives (flavorant, sweeting agent), deionized waters, filter, promptly get pH value and be 5.5～7.5 the light red brown liquid of clear, key component ratio by weight is as follows:
Grape pip procyanidin extract 0.1～30%
95% ethanol 0.1～0.4%
Medicinal glycerin 0.5～5%
Natural menthence 0.03～0.2%
Additives (flavorant, sweeting agent) 0.1～0.4%
Deionized water is assigned to 100%
Procyanidin content in the grape pip procyanidin extract 〉=95% wherein, additives are selected flavorant, sweeting agent for use.
This collutory that contains grape pip procyanidin extract uses as daily oral cavity health care product every day, and caries prevention and periodontitis also can be used for the auxiliary treatment medicine of oral cavity doctor as dental caries and periodontal disease.
Embodiment 2
Measure minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of grape pip procyanidin extract (GSPE) by germ experiment to Streptococcus mutans.Select the international standard bacterial strain for use, the Streptococcus mutans of Streptococcus mutans family (S.mutans Ingbritt, serotype c) and Streptococcus sobrinus (S.Sobrinus 6715, serotype g), anaerobism is cultivated (CO in containing the trypsinization Semen sojae atricolor fluid medium (TSB) of 1% sucrose
280%, N
210%, H
210%), adopt liquid/agar dilution extracorporeal bacteria inhibitor test to measure minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of grape pip procyanidin extract (GSPE) respectively to two kinds of mutans streptococcus, the result is respectively MIC 4.00mg/ml, MBC 8.00mg/ml.
Embodiment 3
Further confirm the anticaries action of grape pip procyanidin extract (GSPE) by zoopery.Select wean age 16 of Sprague-Dawby (SD) rats of 21d Mus, be divided into 2 groups at random, 8 every group, male and female half and half are respectively grape pip procyanidin extract (GSPE) solution, distilled water (H
2O) group.What 21～23d Mus gave between the length of time that Gu has a broad ectrum antibiotic (the 2kg feedstuff adds ampicillin, each 1g of chloromycetin) causes dental caries feedstuff 2000#, added with antibiotic not in the feedstuff At All Other Times.During Mus 24～28d in age, 5d inoculates Streptococcus mutans S.Sobrinus 6715 (10 in the oral cavity continuously
5～6CFU/ml), inoculate 100ul at every turn.Handle with GSPE solution 4mg/ml, the distilled water of MIC concentration respectively for two groups from 29d.Rat is got dorsal position, and the 0.3ml medicine is annotated in rat facing and oral cavity with the indenting ball syringe, keeps 15s, handles every day 1 time, handles in the 30min of back and prohibits diet.Put to death rat after handling 60d continuously, adopt Keyes dental caries point system to observe, assess rat molar occlusal fossa ditch and suffer from the dental caries situation, employing SPSS 13.0 statistical softwares carry out one factor analysis of variance and mean compares, and sum up the preventive effect of GSPE to Sprague-Dawley rat molar occlusal fossa ditch dental caries.Zoopery finds that GSPE can suppress develop (P＜0.05) of rat dental caries; Dx level dental caries decrease and are detected in the distilled water group, and grape pip procyanidin extract (GSPE) group Dx level dental caries does not take place decreases.
Claims (4)
1. a collutory that contains grape pip procyanidin extract is characterized in that, each component is by weight:
Grape pip procyanidin extract 0.1～30%
95% ethanol 0.1～0.4%
Medicinal glycerin 0.5～5%
Natural menthence 0.03～0.2%
Additives 0.1～0.4%
Deionized water is assigned to 100%,
PH value is 5.5～7.5.
2. a kind of collutory that contains grape pip procyanidin extract according to claim 1 is characterized in that additives are flavorant or sweeting agent.
3. a kind of collutory that contains grape pip procyanidin extract according to claim 1, it is characterized in that, described grape pip procyanidin extract is to be pulverized by the Semen Vitis viniferae drying, after the core shell separates, with ethanol in shell, extract, filtration, spray drying get crude extract, crude extract is through solvent staging or dry bronzing powder, procyanidin content in the grape pip procyanidin extract 〉=95% of getting of active carbon adsorption.
4. a kind of application of collutory in preparation auxiliary treatment caries prevention and periodontitis medicine that contains grape pip procyanidin extract according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910154055A CN101692999A (en) | 2009-10-22 | 2009-10-22 | Mouth wash containing grape pip procyanidin extract and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910154055A CN101692999A (en) | 2009-10-22 | 2009-10-22 | Mouth wash containing grape pip procyanidin extract and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101692999A true CN101692999A (en) | 2010-04-14 |
Family
ID=42092027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910154055A Pending CN101692999A (en) | 2009-10-22 | 2009-10-22 | Mouth wash containing grape pip procyanidin extract and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101692999A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103228138A (en) * | 2011-01-22 | 2013-07-31 | 株式会社Az | Sterilization method, sterilization device and bactericide using light |
| CN103282774A (en) * | 2010-12-28 | 2013-09-04 | 狮王株式会社 | Method for determining oral cavity state, and analysis tool, device, and program used for same |
| EP2567734A3 (en) * | 2011-09-06 | 2015-05-06 | Stefanija Krug | Substance for preparing a mouthwash |
| CN105130941A (en) * | 2015-08-31 | 2015-12-09 | 桂林茗兴生物科技有限公司 | Preparation method of grape seed extract |
| CN107998029A (en) * | 2017-12-25 | 2018-05-08 | 扬州大学 | A kind of preparation method of the mouthwash of the leaf extract containing carob |
-
2009
- 2009-10-22 CN CN200910154055A patent/CN101692999A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103282774A (en) * | 2010-12-28 | 2013-09-04 | 狮王株式会社 | Method for determining oral cavity state, and analysis tool, device, and program used for same |
| CN103282774B (en) * | 2010-12-28 | 2015-08-05 | 狮王株式会社 | Method for determining oral cavity state, and analysis tool, device, and program used for same |
| CN103228138A (en) * | 2011-01-22 | 2013-07-31 | 株式会社Az | Sterilization method, sterilization device and bactericide using light |
| EP2567734A3 (en) * | 2011-09-06 | 2015-05-06 | Stefanija Krug | Substance for preparing a mouthwash |
| CN105130941A (en) * | 2015-08-31 | 2015-12-09 | 桂林茗兴生物科技有限公司 | Preparation method of grape seed extract |
| CN107998029A (en) * | 2017-12-25 | 2018-05-08 | 扬州大学 | A kind of preparation method of the mouthwash of the leaf extract containing carob |
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