CN101683424A - Application of Chinese medicine composition in preparation of medicament for treating tonsillitis - Google Patents
Application of Chinese medicine composition in preparation of medicament for treating tonsillitis Download PDFInfo
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Abstract
The invention discloses application of a Chinese medicine composition in the preparation of a medicament for treating tonsillitis. The Chinese medicine composition comprises fructus forsythiae, honeysuckle, Chinese ephedra, bitter almond and the like. The Chinese medicine composition has wide antivirus function, and effectively treats tonsillitis by effectively killing viruses, allaying fever anddiminishing inflammation.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment tonsillitis medicine, belong to the Chinese medicine application.
Background technology
Tonsil was the lymphatic organ of pharynx, and modern medicine thinks that tonsil is the lymphoid tissue of two pharyngeal maximums of human body, increases gradually after general 4～5 years old, began atrophy gradually later on by 12 years old.The opposing of almond physical ability enters the antibacterial in nose and the pharyngeal cavity under the normal condition; human body is played a protective role; but, children's since passive protective physical fitness low; add the flu of suffering from cold; the ability of tonsil opposing antibacterial is weakened, thereby cause oral cavity, pharyngeal, nasal cavity and extraneous antibacterial to invade tonsil, be inflamed.The constitutional tonsillitis is because the foreign body stimulation reaches by due to the intrusion of pathogen such as Hemolytic streptococcus or staphylococcus; The Secondary cases tonsillitis is often sent out in stomatitis, pharyngitis, rhinitis, chronic vomiting etc.
Tonsillitis generally can be divided into acute tonsillitis, chronic tonsillitis.When Abwehrkraft des Koepers reduces due to bacterial infection or the virus, onset is anxious, is cardinal symptom with the pharyngalgia mostly for acute tonsillitis, with symptoms such as fear of cold, heating, headaches, is the child and educates juvenile commonly encountered diseases.Chronic tonsillitis is owing to due to acute tonsillitis shows effect repeatedly, show as pharyngeal drying, and the sense of obstruction is arranged, secretions is sticking, is difficult for expectoration, halitosis, it shows effect repeatedly and can bring out other diseases, as chronic nephritis, arthritis, rheumatic heart disease etc., and therefore must active treatment.
Primary disease is equivalent to the category of Chinese medicine " tonsillitis ", and acute tonsillitis is equivalent to " acute tonsillitis caused by pathogenic windheat ", and chronic tonsillitis is equivalent to " tonsillitis of deficiency type ".Acute tonsillitis caused by pathogenic windheat is many because of the weather cataclysm, the cold and heat imbalance, and lung is defended solid, and cause wind-heat evil toxin and take advantage of a weak point in opponent's defence from mouth and nose from invading pharyngeal tonsils, or because of the surfeit tobacco and wine etc., taste intrinsic heat, or control because of affection due to external wind and heat loses, evil poison is taken advantage of and is passed the lung stomach in the heat, and the pharyngeal tonsils that upward burns is sent out and is primary disease; Tonsillitis of deficiency type is many because of residual poison after acute tonsillitis caused by pathogenic windheat or the epidemic febrile disease is unclear, pathogenic heat consumption impairing the lung the moon, or the factor body deficiency of YIN, and overstrain in addition, damage of kidney-YIN, hyperactivity of deficient fire steams pharyngeal tonsils, sends out to be primary disease.Clinical common pattern of syndrome has:
1, wind and heat in the lung meridian type: card is seen the heating fear of cold, pharyngalgia, cough, Tai Bai or Huang, rapid pulse.
2, accumulated heat in the lung and stomach type: card is seen the hyperpyrexia fear of cold, and pharyngalgia is violent, dysphagia, and thirst and drinking, the halitosis constipation, red tongue, yellow fur is thick, full and rapid pulse.
3, dominance of heat in the interior type: card is seen hyperpyrexia, and the pharynx epilepsy is growing on and on, the pain of picking up the ears of accompanying, and dysphagia, yellow fur matter is red, full and rapid pulse.
4, asthenic fire flaring up type: card is seen dry mouth and throat, and pharyngeal seemingly have thing to stop up sense, dry cough, and companion's feverish sensation in the palms and soles, or breathe hard, the soreness of waist, tongue is few, red tongue, thready and rapid pulse.
5, deficiency of the kidney yin type: card is seen dryness of the mouth and throat, and more so and there is scorching hot hypodynia at people dusk, foreign body sensation, companion's dysphoria with feverish sensation in the chest palms and soles, dizziness is difficult for enduring hardships, pharyngeal tonsils and around rubescent, have the yellow-white purulent core to extrude on the pharyngeal tonsils, the few tongue of red tongue, thready and rapid pulse without strength.
6, asthenia of pulmonosplenic qi type: card is seen dry pharynx, and is scratchy, little coughing, expectorant is few and sticking, cough up and can not tell, people's last hyperhidrosis of sleeping, the dark red company of pharyngeal tonsils and around, the short trace of adularescent point-like on the pharyngeal tonsils, or cheese sample purulent core is extruded the light red tongue less of body of the tongue, thready and rapid pulse.
The treatment of acute tonsillitis mainly is a control infection, and tonsillitis mostly is bacterial infection, and particularly suppurative tonsillitis is suppurated due to the bacterium especially, so generally use antibiotic to treat.Chronic tonsillitis can be made tonsil resection, now quick guillotines of tonsils that adopt, excision more be not later on finish very lucky, can also be again pharyngitis.So ideal method is not excise as far as possible.
Because that is that all right is ripe for the various allelotaxises of child, and the toxic and side effects of antibiotic itself and kill the hazardness of human body normal flora, the organ that is easy to torture or torture potentially the child.In addition, child's abuse of antibiotics, the destruction that is easy to cause normal flora in child's body is reduced child's Abwehrkraft des Koepers, and then is caused superinfection.So suddenly need a kind of good effect, the Chinese medicine patent medicine that side effect is little comes tonsillitis is treated.
The present invention is the improvement invention of carrying out on No. 03143211.5 basis, quotes in full the content of this patent document record at this.The application of unexposed this Chinese medicine composition of above-mentioned patent in the treatment tonsillitis.The present invention has carried out correlational study on its basis, and the application of this Chinese medicine composition in preparation treatment tonsillitis medicine is provided.
Summary of the invention
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment tonsillitis medicine.
Preferably, the tonsillitis of being treated is an acute tonsillitis.
Preferably, the tonsillitis of being treated is a suppurative tonsillitis.
Chinese medicine of the present invention can be had the Chinese medicine of same or similar effect to replace, and these medical materials all can be concocted according to " national Chinese medicine processing standard " or " Chinese medicine voluminous dictionary ".
The object of the invention provides the application of a kind of Chinese medicine composition in preparation treatment tonsillitis medicine, and described Chinese medicine composition is made by following bulk drugs:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
Preferably, this Chinese medicine composition is made by following bulk drugs:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
Or:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
Or:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarums 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
Preferably, in the raw materials used medicine of described Chinese medicine composition, Herba Ephedrae is sweet Herba Ephedrae, and Semen Armeniacae Amarum is a Semen Armeniacae Amarum (parched).
The present invention also provides the active component of described Chinese medicine composition to be made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8-10 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum constitute the active component of this Chinese medicine composition jointly.
The dosage form of medicine of the present invention is capsule, tablet, powder, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, and PEG4000, insect wax etc. (Fan Biting " pharmacy of Chinese materia medica ", the .1997 of Shanghai Science Press December the 1st edition. the adjuvant of each dosage form record).
The preparation method of capsule wherein is to be made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing incapsulates, promptly.
The preparation method of granule wherein is to be made by following steps:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
The preparation method of preferred granule is:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filter liquor that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds 95% ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol gets clear paste filtrate to there not being the alcohol flavor;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, be concentrated into and in the time of 60 ℃, measure relative density and be the thick paste of 1.25-1.35, standby;
(6) step (5) gained thick paste being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
Other dosage forms of medicine of the present invention are in proportion after the weighting raw materials, adopt conventional preparation method preparation, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record makes the acceptable regular dosage form of pharmaceutics.
Pharmaceutical composition of the present invention is by broad-spectrum antiviral, antibiotic, antiinflammatory, effectively treat tonsillitis.
Experimental example:
For confirming the tonsillitic curative effect of Drug therapy of the present invention, use the granule (to call medicine of the present invention in the following text) that makes by embodiment 4, carried out following experimental study:
1 data and method
1.1 physical data
All from Hebei Yi Ling hospital outpatient patient, totally 73 examples are divided into treatment group and matched group to all cases at random.38 examples are organized in treatment, male 23 examples, women 15 examples, 8 months～12 years old age.Tonsil one side or bilateral I degree enlargement 12 examples, II degree enlargement 16 examples, III degree enlargement 10 examples; 37.1 ℃～38 ℃ 13 example of axillaty temperature, 38.1 ℃～39 ℃ 17 example,＞39 ℃ of 8 example.Matched group 35 examples, male 21 examples, women 14 examples, 7 months～11 years old age.Tonsil one side or bilateral I degree enlargement 10 examples, II degree enlargement 14 examples, III degree enlargement 11 examples; 37.1 ℃～38 ℃ 9 example of axillaty temperature, 38.1 ℃～39 ℃ 13 example,＞39 ℃ of 13 example.Two groups of sexes, age, the course of disease, the state of an illness be there was no significant difference (p＞0.05) by statistics, has comparability.
1.2 case is selected inclusion criteria: meet the diagnostic criteria of acute tonsillitis in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ".Exclusion standard: fell ill above 48 hours (1); (2) used antibacterials; (3) part or whole body complication are arranged; (4) the pathology typing belongs to folliculus type person.
1.3 the Therapeutic Method matched group adopts cefixime granule (specification 50mg/ bag) (Baiyunshan Pharmaceutics Stock-sharing Co., Ltd., Guangzhou City's production), and is by 1.5～3.0mg/kg/d, 2 times/day, oral; Tylenol (acetaminophen suspendible drop, Shanghai pharmaceutical Co. Ltd of Johnson ﹠ Johnson produces, specification 15ml/ bottle) ℃ is taken in body temperature＞39, and by specification is oral, and administration in 4～6 hours is 1 time at interval, and 24 hours can not be above 4 times.Two groups of infant heatings, hyperhidrosis or an amount of fluid infusion of difficult person of taking food.The treatment group adds on the matched group basis uses pharmaceutical composition of the present invention, and 1 bag/time, 3 times/day.Be 5 days two groups of courses of treatment.
1.4 curative effect determinate standard: with reference to State Administration of Traditional Chinese Medicine " diagnosis basis of acute tonsillitis, syndrome-classification, efficacy assessment standard ".Cure: pharyngeal transference cure, tonsil are not congested, the no pus point; Take a turn for the better: pharyngeal sx, tonsil pus point are not eliminated entirely; Do not heal: sings and symptoms does not have obvious improvement.
1.5 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation
2Check.
2 results
2.1 clinical efficacy more by statistics, treatment group patient total effective rate is apparently higher than matched group (P＜0.05).The results are shown in Table 1.
Table 1 liang group patient clinical efficacy is (%) relatively
Annotate: * and # compare, P＜0.05.
3 conclusions
This research adds Drug therapy of the present invention on the basis of doctor trained in Western medicine conventional therapy, all being better than simple western medical treatment aspect the raising clinical efficacy, confirm that fully medicine of the present invention has significant clinical efficacy to tonsillitis.
The specific embodiment
Embodiment 1:
The crude drug prescription is:
Fructus Forsythiae 255g Flos Lonicerae 255g Radix Isatidis 255g Radix Et Rhizoma Rhei 51g Herba Pogostemonis 85g
Rhizoma Dryopteris Crassirhizomatis 255g Radix Rhodiolae 85g Mentholum 7.5g honey Herba Ephedrae 85g
Semen Armeniacae Amarum (parched) 85g Herba Houttuyniae 255g Radix Glycyrrhizae 85g Gypsum Fibrosum 255g
Preparation method is:
(1) take by weighing Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times of water gagings decocts to boiling, adding Semen Armeniacae Amarum decocts 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder is added starch 138 grams, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing, 1000 capsules of packing into, promptly.
Embodiment 2:
The crude drug prescription is:
Fructus Forsythiae 300g Flos Lonicerae 200g Radix Isatidis 300g Radix Et Rhizoma Rhei 60g Herba Pogostemonis 100g
Rhizoma Dryopteris Crassirhizomatis 200g Radix Rhodiolae 60g Mentholum 5g Herba Ephedrae 100g
Semen Armeniacae Amarum 60g Herba Houttuyniae 300g Radix Glycyrrhizae 60g Gypsum Fibrosum 300g
Preparation method is:
(1) take by weighing Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 6 times of amount ethanol extractions of 50% 2 times, 3 hours for the first time, 1 hour for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7 times of water gagings decocts to boiling, adding Semen Armeniacae Amarum decocts 2 times, 0.5 hour for the first time, 2.5 hours for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) step (4) gained dried cream powder is added starch 134 grams, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, formulation method is made tablet promptly routinely.
Embodiment 3:
The crude drug prescription is:
Fructus Forsythiae 200g Flos Lonicerae 300g Radix Isatidis 200g Radix Et Rhizoma Rhei 60g Herba Pogostemonis 60g
Rhizoma Dryopteris Crassirhizomatis 300g Radix Rhodiolae 60g Mentholum 9g Herba Ephedrae 60g Semen Armeniacae Amarum 100g
Herba Houttuyniae 200g Radix Glycyrrhizae 100g Gypsum Fibrosum 200g.
Preparation method is:
(1) take by weighing Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 10 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 10 times of amount ethanol extractions of 90% 2 times, 1 hour for the first time, 3 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 11 times of water gagings decocts to boiling, adding Semen Armeniacae Amarum decocts 2 times, 2.5 hours for the first time, 0.5 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, gained filtrate and step (3) gained alcohol extract merges, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, the powder that gets dry extract, standby;
(5) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (4) gained dried cream powder, formulation method is made pill promptly routinely.
Embodiment 4:
The crude drug prescription is:
Fructus Forsythiae 170g Flos Lonicerae 170g Herba Ephedrae (processing) 57g Semen Armeniacae Amarum (stir-fry) 57g
Gypsum Fibrosum 170g Radix Isatidis 170g Rhizoma Dryopteris Crassirhizomatis 170g Herba Houttuyniae 170g
Herba Pogostemonis 57g Radix Et Rhizoma Rhei 34g Radix Rhodiolae 57g Mentholum 5.0g
Radix Glycyrrhizae 57g
Preparation method:
(1) extraction process:
(1) take by weighing Chinese crude drug according to above-mentioned recipe quantity, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis adds 6 times of water gagings extraction volatile oil, carries oil time 4h, collects volatile oil, and oil yield is 0.33 ± 0.05%, and standby behind the extracting liquid filtering, residue discards;
(3) Fructus Forsythiae, Herba Ephedrae (processed), Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting liquid filtering, filtrate merges, and reclaims ethanol to there not being the alcohol flavor, and is standby;
(4) Flos Lonicerae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times of water gagings decocts to boiling, add Semen Armeniacae Amarum (parched), decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting liquid filtering, filtrate merging adds the aqueous solution after step (2) Herba Pogostemonis is carried oil simultaneously, and being condensed into 60 ℃ of mensuration relative densities is the 1.10-1.15 clear paste, adds 95% ethanol, the limit edged stirs, to determining alcohol 70%, cold preservation was placed 24 hours, filtered, filtrate recycling ethanol is to there not being the alcohol flavor, merge with alcohol extract, be concentrated into and be condensed into 60 ℃ and measure relative densities and be the 1.25-1.35 thick paste, standby;
(2) preparation process:
(5) pharmaceutical formulation is: step (4) gained thick paste 335.5g Mentholum 5g
Step (2) gained patchouli oil 0.2ml Icing Sugar 342.5g dextrin 514.0g
(6) granulate: with Icing Sugar and dextrin mix homogeneously, make binding agent system soft material with thick paste, 14 eye mesh screens are granulated, 60-65 ℃ of oven dry, 10 eye mesh screen granulate;
(7) packing: it is an amount of to sift out fine powder, and Mentholum, Herba Pogostemonis Volatile oil are added an amount of ethanol, and dissolving sprays in the fine powder; mix homogeneously, and with the granule mix homogeneously, airtight half an hour, the pack; that is, more than prescription can be made into granule 1000g, according to the packing of 6g/ bag, promptly.
Claims (10)
1, the application of a kind of Chinese medicine composition in preparation treatment tonsillitis medicine is characterized in that being made by following bulk drugs:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
2, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
3, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
4, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarums 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
5, according to each described application of claim 1-4, it is characterized in that the active component of described Chinese medicine composition is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8-10 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum constitute the active component of this Chinese medicine composition jointly.
6,, it is characterized in that described pharmaceutical dosage form is capsule, tablet, powder, granule, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection according to each described application of claim 1-4.
7,, it is characterized in that it being to make by following steps according to the preparation method of the described medicine capsule of claim 6:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing incapsulates, promptly.
8,, it is characterized in that it being to make by following steps according to the preparation method of the described medicinal granule of claim 6:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
9,, it is characterized in that described tonsillitis is an acute tonsillitis according to each described application of claim 1-4.
10,, it is characterized in that described tonsillitis is a suppurative tonsillitis according to each described application of claim 1-4.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109870432A (en) * | 2017-12-05 | 2019-06-11 | 石家庄以岭药业股份有限公司 | One kind is based on the inhibition active detection method of Chinese medicine composition of COX-2 |
| WO2020211088A1 (en) * | 2019-04-19 | 2020-10-22 | 石家庄以岭药业股份有限公司 | Traditional chinese medicine composition and use thereof |
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| CN1194752C (en) * | 2003-07-01 | 2005-03-30 | 河北以岭医药研究院有限公司 | Anti-virus Chinese medicine composition and preparation process thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109870432A (en) * | 2017-12-05 | 2019-06-11 | 石家庄以岭药业股份有限公司 | One kind is based on the inhibition active detection method of Chinese medicine composition of COX-2 |
| WO2019109779A1 (en) * | 2017-12-05 | 2019-06-13 | 石家庄以岭药业股份有限公司 | Detection method for chinese medicine composition based on inhibition of cox-2 activity |
| WO2020211088A1 (en) * | 2019-04-19 | 2020-10-22 | 石家庄以岭药业股份有限公司 | Traditional chinese medicine composition and use thereof |
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