CN101678212A - 用于治疗急性躁狂的氨甲酰基-环己烷类 - Google Patents

用于治疗急性躁狂的氨甲酰基-环己烷类 Download PDF

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Publication number
CN101678212A
CN101678212A CN200880017360A CN200880017360A CN101678212A CN 101678212 A CN101678212 A CN 101678212A CN 200880017360 A CN200880017360 A CN 200880017360A CN 200880017360 A CN200880017360 A CN 200880017360A CN 101678212 A CN101678212 A CN 101678212A
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CN
China
Prior art keywords
chemical compound
effective dose
treatment effective
described method
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880017360A
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English (en)
Chinese (zh)
Inventor
I·拉兹洛维斯基
G·尼梅斯
G·安道尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
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Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to CN201510549993.2A priority Critical patent/CN105193807A/zh
Publication of CN101678212A publication Critical patent/CN101678212A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880017360A 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类 Pending CN101678212A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510549993.2A CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0700370A HUP0700370A2 (en) 2007-05-24 2007-05-24 Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
HUP0700370 2007-05-24
PCT/HU2008/000052 WO2008142463A2 (en) 2007-05-24 2008-05-19 Carbamoyl-cyclohexanes for treating acute mania

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510549993.2A Division CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Publications (1)

Publication Number Publication Date
CN101678212A true CN101678212A (zh) 2010-03-24

Family

ID=89987541

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510549993.2A Pending CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类
CN200880017360A Pending CN101678212A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201510549993.2A Pending CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Country Status (26)

Country Link
US (1) US20100197704A1 (enExample)
EP (1) EP2164572B2 (enExample)
JP (1) JP2010527985A (enExample)
KR (1) KR20150076266A (enExample)
CN (2) CN105193807A (enExample)
AU (1) AU2008252621B2 (enExample)
CA (1) CA2687528C (enExample)
CY (1) CY1113566T1 (enExample)
DK (1) DK2164572T4 (enExample)
EA (1) EA021936B1 (enExample)
ES (1) ES2397962T5 (enExample)
GE (1) GEP20135731B (enExample)
HR (1) HRP20130092T4 (enExample)
HU (1) HUP0700370A2 (enExample)
IL (1) IL202048A (enExample)
MX (1) MX2009012752A (enExample)
MY (1) MY148955A (enExample)
NZ (1) NZ582284A (enExample)
PL (1) PL2164572T5 (enExample)
PT (1) PT2164572E (enExample)
RS (1) RS52613B2 (enExample)
SI (1) SI2164572T2 (enExample)
TW (1) TWI428130B (enExample)
UA (1) UA101323C2 (enExample)
WO (1) WO2008142463A2 (enExample)
ZA (1) ZA200908283B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CN102014909B (zh) * 2008-02-21 2013-03-13 田边三菱制药株式会社 口服用固体制剂
KR101612146B1 (ko) 2008-07-16 2016-04-12 리히터 게데온 닐트. 도파민 수용체 리간드를 함유하는 약학적 제형
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
US9610274B2 (en) * 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8912197B2 (en) 2012-08-20 2014-12-16 Forest Laboratories Holdings Ltd. Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829703A (zh) * 2003-08-04 2006-09-06 匈牙利吉瑞大药厂 作为d3/d2受体拮抗剂的(硫代)氨基甲酰基－环己烷衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122576B2 (en) * 2001-02-27 2006-10-17 Plata-Salaman Carlos R Carbamate compounds for use in preventing or treating bipolar disorder
MY148643A (en) * 2007-05-11 2013-05-15 Richter Gedeon Nyrt Solvate and crystalline forms of carbamoyl-cyclohexane derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829703A (zh) * 2003-08-04 2006-09-06 匈牙利吉瑞大药厂 作为d3/d2受体拮抗剂的(硫代)氨基甲酰基－环己烷衍生物

Also Published As

Publication number Publication date
EP2164572A2 (en) 2010-03-24
UA101323C2 (en) 2013-03-25
CY1113566T1 (el) 2016-06-22
DK2164572T4 (en) 2016-01-04
EP2164572B2 (en) 2015-09-16
HRP20130092T4 (hr) 2016-01-01
EA021936B1 (ru) 2015-10-30
IL202048A (en) 2014-11-30
WO2008142463A2 (en) 2008-11-27
EP2164572B1 (en) 2012-11-14
IL202048A0 (en) 2010-06-16
PL2164572T3 (pl) 2013-04-30
AU2008252621B2 (en) 2013-09-19
MX2009012752A (es) 2010-03-15
PT2164572E (pt) 2013-01-28
SI2164572T1 (sl) 2013-02-28
SI2164572T2 (sl) 2016-01-29
GEP20135731B (en) 2013-01-25
HUP0700370A2 (en) 2009-04-28
HK1136984A1 (en) 2010-07-16
JP2010527985A (ja) 2010-08-19
MY148955A (en) 2013-06-14
DK2164572T3 (da) 2013-02-11
NZ582284A (en) 2012-07-27
RS52613B (sr) 2013-04-30
HRP20130092T1 (en) 2013-02-28
CA2687528C (en) 2016-07-05
ES2397962T3 (es) 2013-03-12
KR20150076266A (ko) 2015-07-06
ES2397962T5 (es) 2016-01-08
RS52613B2 (sr) 2018-05-31
PL2164572T5 (pl) 2016-02-29
CA2687528A1 (en) 2008-11-27
TWI428130B (zh) 2014-03-01
TW201002326A (en) 2010-01-16
AU2008252621A1 (en) 2008-11-27
EA200971087A1 (ru) 2010-04-30
WO2008142463A3 (en) 2009-03-05
US20100197704A1 (en) 2010-08-05
CN105193807A (zh) 2015-12-30
HU0700370D0 (en) 2007-07-30
ZA200908283B (en) 2010-08-25

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Application publication date: 20100324