CN101675342A - 测量凝血酶受体拮抗剂对血小板聚集的抑制的方法 - Google Patents

测量凝血酶受体拮抗剂对血小板聚集的抑制的方法 Download PDF

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Publication number
CN101675342A
CN101675342A CN200880014577A CN200880014577A CN101675342A CN 101675342 A CN101675342 A CN 101675342A CN 200880014577 A CN200880014577 A CN 200880014577A CN 200880014577 A CN200880014577 A CN 200880014577A CN 101675342 A CN101675342 A CN 101675342A
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Prior art keywords
thrombin receptor
trap
thrombin
par
blood sample
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CN200880014577A
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Chinese (zh)
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丹尼斯·德宾
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Accumetrics Inc
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Accumetrics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39744746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101675342(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Accumetrics Inc filed Critical Accumetrics Inc
Publication of CN101675342A publication Critical patent/CN101675342A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880014577A 2007-05-03 2008-05-02 测量凝血酶受体拮抗剂对血小板聚集的抑制的方法 Pending CN101675342A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91582007P 2007-05-03 2007-05-03
US60/915,820 2007-05-03
PCT/US2008/062415 WO2008137673A1 (en) 2007-05-03 2008-05-02 Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists

Publications (1)

Publication Number Publication Date
CN101675342A true CN101675342A (zh) 2010-03-17

Family

ID=39744746

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880014577A Pending CN101675342A (zh) 2007-05-03 2008-05-02 测量凝血酶受体拮抗剂对血小板聚集的抑制的方法

Country Status (7)

Country Link
US (1) US20080299587A1 (cg-RX-API-DMAC7.html)
EP (1) EP2153235B1 (cg-RX-API-DMAC7.html)
JP (2) JP5514101B2 (cg-RX-API-DMAC7.html)
KR (2) KR20150051243A (cg-RX-API-DMAC7.html)
CN (1) CN101675342A (cg-RX-API-DMAC7.html)
ES (1) ES2387700T3 (cg-RX-API-DMAC7.html)
WO (1) WO2008137673A1 (cg-RX-API-DMAC7.html)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102843967A (zh) * 2010-03-24 2012-12-26 Ca卡西索股份公司 用于确定至少一个血液样品的至少一个评估参数的方法和装置
CN103969228A (zh) * 2013-02-04 2014-08-06 百奥泰生物科技(广州)有限公司 一种整合素GP IIb/IIIa特异性结合分子巴替非班的生物学效应检测方法
CN105717263A (zh) * 2016-03-04 2016-06-29 北京乐普医疗科技有限责任公司 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用
CN110051692A (zh) * 2019-04-12 2019-07-26 南京市第一医院 一种血小板定向释放生长因子的组合物及其制备方法
CN111788300A (zh) * 2017-12-28 2020-10-16 株式会社钟化 细胞聚集抑制剂
CN116794333A (zh) * 2022-12-22 2023-09-22 北京乐普诊断科技股份有限公司 一种全面激活血小板基础凝集功能的激活剂配方及其制备方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
EP1641492B1 (en) * 2003-07-08 2011-12-14 Accumetrics, Inc. Controlled platelet activation to monitor therapy of adp antagonists
EP2286199A2 (en) * 2008-06-09 2011-02-23 Accumetrics, Inc. Hubbed dual cannula device for closed container sampling systems
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
WO2011133450A2 (en) * 2010-04-19 2011-10-27 Meso Scale Technologies, Llc. Serology assays
PT3067431T (pt) * 2010-09-15 2019-10-29 Debiopharm Int Sa Dispositivo incluindo componentes sanguíneos para separação de moléculas ou partículas alvo a partir de amostras
RU2559873C2 (ru) * 2011-04-27 2015-08-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Миметики поли (adp-рибозы) и способ их получения
WO2015061733A1 (en) * 2013-10-25 2015-04-30 Bristol-Meyers Squibb Company Diagnostic methods for par4 antagonist therapy
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
CN109884326B (zh) * 2019-03-27 2022-08-19 深圳优迪生物技术有限公司 血小板聚集功能检测试剂盒
CA3153941A1 (en) * 2019-10-17 2021-04-22 Mary POMEROY Coagulation assay apparatus and methods thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518057A (en) * 1966-04-22 1970-06-30 Huron Road Hospital Method and apparatus for thrombus formation time determinations
US3694161A (en) * 1971-04-14 1972-09-26 Armour Pharma Method for measuring platelet aggregation
US4051236A (en) * 1973-02-15 1977-09-27 E. R. Squibb & Sons, Inc. Inhibition of blood platelet aggregation
FI58700C (fi) * 1974-02-21 1981-03-10 Braun Melsungen Ag Foerfarande foer maetning av blodplaettars spontanaaggregation i blodplaettsrik citratplasma
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
US5066592A (en) * 1988-03-08 1991-11-19 Temple University Of The Commonwealth System Of Higher Education Trigramin - a platelet aggregation inhibiting polypeptide
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
US6221672B1 (en) * 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
US6043871A (en) * 1997-03-03 2000-03-28 Brigham Young University System and method for measuring blood platelet function
US5922551A (en) * 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
US6210904B1 (en) * 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
WO1999043809A2 (en) * 1998-02-27 1999-09-02 The Regents Of The University Of California Protease-activated receptor 4 and uses thereof
TWI302913B (en) * 2000-06-15 2008-11-11 Schering Corp Thrombin receptor antagonists
ES2282304T3 (es) * 2000-11-01 2007-10-16 Astellas Pharma Inc. Procedimiento para seleccionar antiplaquetas.
US6841354B2 (en) * 2000-12-21 2005-01-11 Philadelphia, Health & Education Corporation Screening assay for anti-thrombotic/anti-platelet activity
KR100749795B1 (ko) * 2001-04-19 2007-08-17 에자이 알앤드디 매니지먼트 가부시키가이샤 2-이미노피롤리딘 유도체
JP2004533840A (ja) * 2001-07-06 2004-11-11 ジェネンテック・インコーポレーテッド ファージディスプレイによるｐｄｚドメインリガンド
WO2003033501A1 (en) * 2001-10-18 2003-04-24 Schering Corporation Himbacine analogues as thrombin receptor antagonists
AU2003277398A1 (en) * 2002-10-15 2004-05-04 The University Of Tennessee Research Foundation Methods for assessment of platelet aggregation
EP1641492B1 (en) * 2003-07-08 2011-12-14 Accumetrics, Inc. Controlled platelet activation to monitor therapy of adp antagonists
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7595169B2 (en) * 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
WO2007007588A1 (ja) * 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. 平面性を有する環状基を母核とする化合物

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102843967A (zh) * 2010-03-24 2012-12-26 Ca卡西索股份公司 用于确定至少一个血液样品的至少一个评估参数的方法和装置
CN102843967B (zh) * 2010-03-24 2015-09-09 Ca卡西索股份公司 用于确定至少一个血液样品的至少一个评估参数的方法和装置
CN103969228A (zh) * 2013-02-04 2014-08-06 百奥泰生物科技(广州)有限公司 一种整合素GP IIb/IIIa特异性结合分子巴替非班的生物学效应检测方法
CN105717263A (zh) * 2016-03-04 2016-06-29 北京乐普医疗科技有限责任公司 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用
CN105717263B (zh) * 2016-03-04 2018-01-26 北京乐普医疗科技有限责任公司 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用
CN111788300A (zh) * 2017-12-28 2020-10-16 株式会社钟化 细胞聚集抑制剂
CN111788300B (zh) * 2017-12-28 2024-08-13 株式会社钟化 细胞聚集抑制剂
CN110051692A (zh) * 2019-04-12 2019-07-26 南京市第一医院 一种血小板定向释放生长因子的组合物及其制备方法
CN116794333A (zh) * 2022-12-22 2023-09-22 北京乐普诊断科技股份有限公司 一种全面激活血小板基础凝集功能的激活剂配方及其制备方法

Also Published As

Publication number Publication date
US20080299587A1 (en) 2008-12-04
EP2153235B1 (en) 2012-05-16
JP5514101B2 (ja) 2014-06-04
EP2153235A1 (en) 2010-02-17
KR20150051243A (ko) 2015-05-11
WO2008137673A1 (en) 2008-11-13
ES2387700T3 (es) 2012-09-28
JP2014052388A (ja) 2014-03-20
JP2010526319A (ja) 2010-07-29
KR20100017576A (ko) 2010-02-16

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Application publication date: 20100317