CN101669999A - External traditional Chinese medicine preparation for treating fungal dermatopathy - Google Patents
External traditional Chinese medicine preparation for treating fungal dermatopathy Download PDFInfo
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- CN101669999A CN101669999A CN200910205367A CN200910205367A CN101669999A CN 101669999 A CN101669999 A CN 101669999A CN 200910205367 A CN200910205367 A CN 200910205367A CN 200910205367 A CN200910205367 A CN 200910205367A CN 101669999 A CN101669999 A CN 101669999A
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Abstract
The invention discloses an external traditional Chinese medicine preparation for treating fungal dermatopathy, which is mainly composed of 20-50 parts of rhubarb, 20-50 parts of dried alum, 20-65 parts of mirabilite, 45-105 parts of sulphur, 3-10 parts of borneol and 125-265 parts of realgar. The preparation method comprises the following steps: pulverizing the rhubarb, the dried alum and the realgar to mix with other medicines, evenly stirring, placing the obtained mixture into a ceramic or glass container, pouring 130-260 parts of alcoholic solution containing 65-85% of ethanol, soaking at normal temperature for over 150h, then adding 340-720 parts of purified water, fully stirring, soaking for over 30h, filtering soak solution, precipitating the obtained filtrate for over 80h, sucking out the precipitated filtrate, sub-packaging and sealing the precipitated filtrate in the containers to obtain the finished product. The preparation has the characteristics of high and quick effect, simple components, easy preparation, low cost, no toxic and side effect, conformity to the pharmacopoeia requirement, no recurrence after curing and being safe and economical.
Description
Background technology:
Fungus is one of refractory bacterium in the antibacterial, good sending out in warm, moist environment, dermatomycosis in China torrid zone, the subtropical zone sickness rate is higher, it is the infectious skin disease that prevalence is very high among the crowd, skin, the brothers of main scalp of invading the people, hair, extremity trunk and refer to (toe) first, according to the infection morbidity position, can be divided into tinea capitis, tinea corporis, tinea cruris, the tinea manuum, tinea pedis and tinea unguium etc.Behind the human infection, the Chang Fanfu outbreak makes the patient very painful, and existing medicine is difficult to radical cure again.Western medicine mainly with 1% Terbinafine hydrochloride emulsifiable paste, daktarin, adopt medicines such as the tinea of pleasure, health king, clotrimazole and Japan is clear and treat.Chinese medicine then with JIAOXIAN YICIJING, antiinflammatory skin moistening and itch stopping loose, happy hundred tinea of Mactra sulcatria Deshayes disappear and set upright toxin expelling therapy etc. and treat, long, easily recurrence said medicine ubiquity course of treatment, the shortcoming that expense is high.Chinese patent (publication number 101274093 and 101518600) discloses the Chinese prescription of two kinds of treatment dermatomycosiss, and they all exist, and medicine is many, prescription is complicated, needs shortcoming for oral administration, that external is carried out simultaneously.
Summary of the invention:
The objective of the invention is to disclose a kind of be used for the treatment of dermatomycosis have that prescription is simple, short treating period, evident in efficacy, make easily, cure rate is high and do not recur the Chinese medicine for external application of characteristics.
It " DIANDAO SAN " (its prescription is sulfur, Radix Et Rhizoma Rhei from ancient prescription " doctor ancestor gold prison " in drug screening of the present invention, regulation according to the 267th page of the Chinese Pharmacopoeia of publishing in 2000, sulfur dosage is: feed ration for oral administration is 1.5-3g, suitable amount used externally) and " two flavor Herba Sidae Szechuensis " (its prescription is Realgar, Alumen, the 277th page of regulation of Chinese Pharmacopoeia, the dosage of Realgar is: feed ration 0.05--0.1g for oral administration, and external is also an amount of; Alumen dosage is for oral administration to be 1.5--3g, suitable amount used externally).By experiment (dosage is: Realgar 30g, vaseline 70g mixes well outer being coated with) and confirm that Realgar external 30g is a threshold dose, surpass this dosage and then easily cause poisoning.Get above-mentioned two prescriptions and test respectively, find that two prescriptions all have the effect that suppresses fungus, but its therapeutic evaluation only is general.And then two prescriptions are merged test, find that its inhibition effect to fungus strengthens to some extent than folk prescription, therapeutic evaluation should belong to medium.For curative effect is further improved, changing the Alumen in the prescription into its concentrate is dried Alumen, then with the main medicine sulfur among two sides, Realgar gradually dosage test successively, find that its curative effect is really in remarkable increase, yet, along with the increase of dosage, its toxic and side effects also obviously increases the weight of, and how to reach to keep its bacteriostatic effect, do not increase its toxic and side effects again, become a thorny difficult problem one, carried out 200 for this reason surplus time test, also fail to find the break-through point.Afterwards, by reading over " conventional Chinese medicine teaching materials " (chief editor of Chengdu Traditional Chinese Medical College, publication of Shanghai science tech publishing house, in July, 1964, front page was the 17th page) argumentation of relevant compatibility, wherein talk about: " if meet a little medicines when fit applications, wherein a medicine pins down another medicine; thus reduce or eliminate its toxicity, or other illeffects, in this case; with regard to the former; subdued another medicine, be mutual-detoxication relation, from the latter; be limited by the former, be that mutual restraint between two drugs concerns ".Shennong's Herbal is also pointed out: " if poisonous should the system, available mutual restraint between two drugs phase senilicide ".In " teaching materials " this section, also mention simultaneously: " medicine that some mutual restraint between two drugs are also arranged but can not share exceptionally ".The medicine of " nineteen medicaments of mutual restraint " is exactly the exemplary that can not share.Since mention the effect that the medicine of incompatibility has the mutual restraint between two drugs mutual-detoxication in the book, why can not in this forbidden zone, seek and break through good opportunity?
" nineteen medicaments of mutual restraint " formulas or directions put into verse one of them " sulfur is former to be smart in the fire, and Mirabilitum sees just and disaccords " (Natrii Sulfas, Mirabilitum, Matrii Sulfas Exsiccatus are same thing, only the form difference).This two herbal medicine is the listed incompatibility of successive dynasties Chinese materia medica.Through studying repeatedly, imagine, weighing, since there is the relation of " striving " in it in " nineteen medicaments of mutual restraint " formulas or directions put into verse, its hybrid combination will inevitably produce the reaction of the mutual restraint between two drugs mutual-detoxication so, perhaps also simultaneously may produce new chemical compound, so, its result is possible nothing more than three kinds: the one, and the mutual-detoxication, promptly effect is offset each other; The 2nd, mutual restraint between two drugs is lowered or elimination their toxicity; The 3rd, interpromoting relation in five elements, promptly new chemical compound produces.Reasoning in view of the above with sulfur and two kinds of drug combinations of Natrii Sulfas, perhaps has miracle and occurs.Result of the test has confirmed the correctness of reasoning, following situation occurred: one, positive interaction reduces, the effect that promptly suppresses fungus obviously reduces than the bacteriostasis of folk prescription it " DIANDAO SAN ", and this may be to determine one of reason that one of " nineteen medicaments of mutual restraint " sulfur and two kinds of medicines of Natrii Sulfas can not be compatible in the ancient prescription; Two, the toxicity complete obiteration in the sulfur; Three, the compatibility afterreaction has generated new chemical compound.In order to confirm this result, the inventor repeatedly is coated with examination with this compatibe drug on own skin, finds that the skin that is coated with the examination position stands intact, and does not have uncomfortable sensation.This illustrates that generating new chemical compound behind these two kinds of compatibility of drugss makes it toxic and side effects and eliminate fully.Add " two flavor Herba Sidae Szechuensiss " (Realgar, dried Alumen) again and do experiment again, its result similarly, as described above, the positive interaction effect has only fraction to reduce, the toxic and side effects in " Realgar " is also all eliminated.Through constantly adjusting dosage, find best proportion compatibility finally, make it become safety, potent press down mycocidal Chinese medicine for outer use.By the certificate of analysis of Bureau of Drugs Supervision, pharmaceutical factory, this preparation system safely, the Chinese medicine for outer use that has no side effect, meet the pharmacopeia codes and standards.
Sulfur is the refinement processed goods in crude sulfur ore deposit, sour in the mouth, temperature, property is slightly poisonous, external has the effect of detoxifcation parasite killing, dissipation carbuncle of yin nature, after skin secretion contacts, produce hydrogen sulfide and pentathionic acid, the dissolving cutin is arranged and kill dermatozoon and the effect of inhibition dermatophytes, be used for various skin diseases such as scabies, tinea alba, normal and detoxify dampness, killing parasites for relieving itching medicine compatibility; But benefiting the fire of the gate of life to invigorate YANG for oral administration.
Realgar is arsenical crystallization Ore, main Containing Sulfur arsenic, and acrid in the mouth, temperature, property is poisonous, and some antibacterial is had killing action, and multiple common dermatophytes is had inhibitory action, and detoxifcation, disinsection efficiency are arranged, and is used for furuncle furunculosis, scabies, worm venom etc.
Alumen is the refinement product of alunite, main sulfur acid aluminum potassium, and sour in the mouth, puckery, warm in nature, go the concentrate of its water of crystallization to be dried Alumen, relieving diarrhea with astringents, astringing to arrest bleeding are arranged, eliminate the phlegm, removing dampness itching relieving effect; Be used for diseases such as carbuncle sore tumefacting virus, eczema, scabies outward.
Borneolum Syntheticum is to be raw material with Oleum Terebinthinae, Camphora etc., and through the synthetic Borneolum Syntheticum of chemical method, acrid in the mouth, hardship, cold nature have and have one's ideas straightened out and the effect of clearing away heat to alleviate pain, can be used for the fervid sufferings of skin infection etc. outward, and its dosage is for oral administration to be 0.03--0.1g, suitable amount used externally.
Natrii Sulfas be contain sodium sulfate natural minerals through the refining crystalline solid that forms, bitter in the mouth, salty, is used for diseases such as skin skin ulcer rash and fervid sufferings outward, dosage 9--15g for oral administration, suitable amount used externally at property Great Cold.
Radix Et Rhizoma Rhei is the Polygonaceae herbaceos perennial, and its rhizome is used as medicine bitter in the mouth after doing, cold in nature, the effect of capturing stagnant, purging fire and cooling blood, blood circulation promoting and blood stasis dispelling, promoting the function of the gallbladder to alleviate jaundice is arranged, a lot of antibacterials and most dermatophytes there are inhibitory action, dosage 3--12g every day for oral administration, each 1.5--3g, suitable amount used externally.
Technical scheme of the present invention is: following medicine is weighed Radix Et Rhizoma Rhei 20--50 part, dried Alumen 20--50 part, Natrii Sulfas 20--65 part, sulfur 45--105 part, Borneolum Syntheticum 3--10 part, Realgar 125--265 part respectively according to the prescription ratio.Behind its pulverize separately, mix with above-mentioned other medicines and stir, put into pottery or glass container, pour the alcoholic solution 130--260 part that contains ethanol 65--85% again into, soak at normal temperatures and pressures more than 150 hours.Add pure water 340--720 part then, soak again more than 30 hours after fully stirring, at last soak is filtered, precipitate filtrate more than 80 hours again, promptly become the preparation finished product, the good filtrate sucking-off of precipitation, packing and be sealed in each ceramic vessel or glass, plastic bottle in stand-by.
Verify more than 3 years through clinical observation, to the skin infection that causes by fungus, mycete, as the tinea manuum (fungal infection of hand and foot), tinea pedis (tinea pedis), tinea capitis (seborrheic dermatitis), tinea versicolor (tinea versicolor), tinea corporis, tinea cruris, women's pruritus vulvae and other disease sites of body surface, treat 500 multiple-cases, all Zhi More does not in a short time have recurrence.That said preparation has is efficiently quick-acting, prescription simple, make easily, expense is cheap, safety economy, have no side effect, meet pharmacopeia and require behind the, Zhi More the no longer characteristics of recurrence.
The specific embodiment:
With following medicine according to qualifications choosing choose, weigh respectively according to the prescription ratio then: Radix Et Rhizoma Rhei 23g, dried Alumen 20g, Natrii Sulfas 26g, sulfur 50g, Borneolum Syntheticum 4g, Realgar 140g.Radix Et Rhizoma Rhei is smashed to pieces, dried Alumen, Realgar are ground, then, they are mixed together together with Natrii Sulfas, sulfur, Borneolum Syntheticum and stir, put into the glass wide mouthed bottle, the alcoholic solution 160ml that will contain ethanol 75% again pours in the bottle, soaks at normal temperatures and pressures 150 hours.Add pure water 480ml then, soaked again after stirring 30 hours, at last soak is filtered with 4 layers of gauze folding,, the good filtrate sucking-off of precipitation, be sub-packed in each vial with siphon again with filtrate precipitation 80 hours.
Dip in the said preparation finished medicines with cotton swab, the ill skin of spot printing and on every side is coated with and puts on the skin once or for several times every day.For suffering from the little person of skin area, only need be coated with and put 5--7 days on the skin, long for medical history, suffer from the big person of skin area, need be coated with and put on the skin about 10 days, the Quan More that can return to one's perfect health is not if contact with fungus or no longer by its infection, then no longer recur after the rehabilitation.
Claims (3)
1, a kind of Chinese medicine for outer use for the treatment of dermatomycosis, it is characterized in that described preparation is made up of following medicine, medicine name and part by weight are: Radix Et Rhizoma Rhei 20--50 part, dried Alumen 20--50 part, Natrii Sulfas 20--65 part, sulfur 45--105 part, Borneolum Syntheticum 3--10 part, Realgar 130--260 part, with Radix Et Rhizoma Rhei, dried Alumen and Realgar pulverize separately, after again they being mixed together with above-mentioned other medicines, stir, put into container, pour the alcoholic solution 130--260 part that contains ethanol 65--85% again into, soak more than 150 hours, add pure water 340--720 part then, soak again more than 30 hours after fully stirring.
2, a kind of Chinese medicine for outer use for the treatment of dermatomycosis according to claim 1 is characterized in that soaking and carries out at normal temperatures and pressures.
3, a kind of Chinese medicine for outer use for the treatment of dermatomycosis according to claim 1 is characterized in that soak is filtered, and again the filtrate precipitation more than 80 hours, is precipitated good filtrate and is the preparation finished product.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102406658A (en) * | 2011-11-29 | 2012-04-11 | 丁荣松 | Paste plaster for treating psoriasis and preparation method thereof |
CN103181950A (en) * | 2012-01-03 | 2013-07-03 | 李淑玉 | Traditional Chinese medicine for treating cervical erosion and manufacturing method |
CN103251801A (en) * | 2013-05-03 | 2013-08-21 | 周用华 | Formula of medicine liquid for treating skin disease and preparation method of medicine liquid |
CN103655788A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for treating dermatophytosis |
CN106176991A (en) * | 2016-08-31 | 2016-12-07 | 梁小荣 | The Chinese medicine preparation of preventing and treating Holland dwarf's rabbit dermatomycosis and preparation method |
-
2009
- 2009-10-08 CN CN200910205367A patent/CN101669999A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406658A (en) * | 2011-11-29 | 2012-04-11 | 丁荣松 | Paste plaster for treating psoriasis and preparation method thereof |
CN103181950A (en) * | 2012-01-03 | 2013-07-03 | 李淑玉 | Traditional Chinese medicine for treating cervical erosion and manufacturing method |
CN103251801A (en) * | 2013-05-03 | 2013-08-21 | 周用华 | Formula of medicine liquid for treating skin disease and preparation method of medicine liquid |
CN103655788A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for treating dermatophytosis |
CN103655788B (en) * | 2013-12-11 | 2016-03-16 | 刘梅 | A kind of Chinese medicine composition being used for the treatment of beriberi |
CN106176991A (en) * | 2016-08-31 | 2016-12-07 | 梁小荣 | The Chinese medicine preparation of preventing and treating Holland dwarf's rabbit dermatomycosis and preparation method |
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Application publication date: 20100317 |