CN100512878C - Medicament for treating acarodermatitis of human face and preparation method thereof - Google Patents
Medicament for treating acarodermatitis of human face and preparation method thereof Download PDFInfo
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- CN100512878C CN100512878C CNB2005100486330A CN200510048633A CN100512878C CN 100512878 C CN100512878 C CN 100512878C CN B2005100486330 A CNB2005100486330 A CN B2005100486330A CN 200510048633 A CN200510048633 A CN 200510048633A CN 100512878 C CN100512878 C CN 100512878C
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- silicon cream
- aluminis
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- medical silicon
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- 239000003814 drug Substances 0.000 title claims abstract description 22
- 206010063409 Acarodermatitis Diseases 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000002674 ointment Substances 0.000 claims abstract description 21
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 18
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000003756 stirring Methods 0.000 claims abstract description 17
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000006071 cream Substances 0.000 claims abstract description 13
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 13
- 239000010703 silicon Substances 0.000 claims abstract description 13
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 11
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000004327 boric acid Substances 0.000 claims abstract description 9
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 9
- 239000011787 zinc oxide Substances 0.000 claims abstract description 9
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000000227 grinding Methods 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 17
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 7
- 239000005864 Sulphur Substances 0.000 claims description 6
- 229960003639 laurocapram Drugs 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 201000004700 rosacea Diseases 0.000 abstract description 7
- 206010000496 acne Diseases 0.000 abstract description 5
- 239000009969 fructus bruceae Substances 0.000 abstract description 3
- 239000003921 oil Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 abstract 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 abstract 2
- 241001671311 Laurus Species 0.000 abstract 2
- 229940037003 alum Drugs 0.000 abstract 2
- 229960004873 levomenthol Drugs 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 238000004945 emulsification Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 9
- 241001303601 Rosacea Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000035618 desquamation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 206010013700 Drug hypersensitivity Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 229960002645 boric acid Drugs 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000005311 drug allergy Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003129 miticidal effect Effects 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000009521 phase II clinical trial Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960005349 sulfur Drugs 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a medicine used for curing face acarodermatitis of people and the preparation method thereof, in particular to rosacea and acne. The medicine is characterized in that the medicine is prepared in the following method that: medical silicon cream is put into a vessel with heating and stirring devices, and then the medical silicon cream is heated and stirred at the temperature ranging from 39 to 45 DEG C and a stirring rate ranging from 50 to 70r/m. Mentha camphor, zinc oxide, boric acid, sublimed sulfur, salicylic acid, fructus bruceae oil, laurus azone, alum glycerite are put into the vessel filled with silicon cream in turn. Then the materials are mixed and stirred. After the materials are even, the materials are put into a muller for grinding. After an even stirring, the powder is put into an emulsification pot and emulsified into delicate ointment. The weight ratio of the medical silicon cream to the mentha camphor to the zinc oxide to the boric acid to the sublimed sulfur to the salicylic acid to the fructus bruceae oil to the laurus azone to the alum glycerite ranges from: 68:1.5:6.5:1.5:6.5:0.5:0.5:3.5 to 78: 2.7: 7.6: 2.7: 7.6: 1.8: 1.5:0.5:5.2.
Description
Affiliated technical field
The present invention relates to medicine of a kind of human face's of treatment acarodermatitis and preparation method thereof, it is specially adapted to treat rosacea and comedo.
Background technology
Rosacea and comedo are a kind of common skin diseases, and this disease not only influences health, also can destroy the normal fitness of people's face skin, bring spiritual worries to the patient.The inventor is through the precious disconnected treatment statistics of the clinical inspection demodicid mite in 40 years, and rosacea and comedo all are to cause a disease because of human vermiform mite infection.Examine demodicid mite and turn out cloudy after " Central Region ointment " treatment with inventor's development, inflammation disappears.Therefore, started ill the treatment, anosis (healthy band demodicid mite people) can prevent the medicine of falling ill.The inventor is since development in 1956 and clinical treatment, this ointment process nineteen ninety new drug is declared, the poison of drug reason, pharmacodynamics test, skin kills the demodicid mite test, phase ii clinical trial, new drug evaluation total effective rate is 95.5%, cure rate is 86.4%, through the specified three large hospital clinical trial conclusions of country: " survey and be called the efficient medicine for the treatment of rosacea ", reply is for the accurate word H53021786 of traditional Chinese medicines number, national drug standards WS-10001-(HD-0193)-2002, submitted " a kind of preparation method of rosacea ointment " secret patent application on October 29th, 1987 to Patent Office of the People's Republic of China, this method is in order successively with Mentholum, liquid paraffin and medicinal zinc oxide, salicylic acid, boric acid, sulfur, vaseline drops in the grinder and carries out mixed grinding.On May 7th, 1994, Chinese Patent Office authorized secret patent, and the patent No. is: ZL87105110.9.Producing code from reply in 1993 for the accurate word of medicine, by the favorable comment that has been subjected to domestic and international patient and travelling trader since the production and sales of Central Region, Yunnan drugmaker deeply, be the economic benefit of the more than one hundred million units of wound of country simultaneously, and the Mei Ya various countries is beaten up in outlet.Though this ointment has higher cure rate, but in treatment, also find some problems and defective, the sx phenomenon appears in the patient who has in medication ten days initial stages of treatment as the patient, skin rubefaction, and it is many that pimple becomes, inflammation increases the weight of, desquamation etc., the patient who makes thinks it is drug allergy by mistake, and produces the feared state of mind, be the reaction of medicine miticidal effect in fact, it is greasy to feel that skin does not accommodate after the hotter geographic patient of southern climates applies ointment in addition.
Summary of the invention
The present invention aims to provide a kind of cure rate height, and the drug reaction side effect is little, and pharmaceutical properties is good, is applicable to that more facial acarodermatitis medicine and preparation method thereof is gone in the treatment of patient treatment.
The technical scheme of technical solution problem of the present invention is: in order to solve the problem that former patent ointment exists, clinical research repeatedly and test have been carried out, 1, the substrate vaseline of former ointment is changed is medical silicon cream, solved the sensation of feeling the skin greasing discomfort after patient's medication.The permeability and the anti-sunlight function of ointment have been increased again.2, the Fructus Bruceae in former ointment oil oral liquid is changed be pure Fel Anas domestica seed oil, so not only reduced the moisture content of ointment but also kept the stability of ointment.3, for quickening curative effect, the permeability that strengthens ointment in ointment, increased the skin penetrant laurocapram.4, kill demodicid mite antiinflammatory effect for further improving ointment, in ointment, increased the glycerinum aluminis solution that contains Alumen 8-12% that treatment burn, scald, the oral ulcer of my development are used, so both strengthened demodicid mite antiinflammatory effect extremely, solved medication initial stage desquamation phenomenon again, prescription and preparation method after the improvement are as follows:
In the container that has heating and stir, drop into medical silicon cream and heat and stir according to the character of medicine and pharmacological action, heating-up temperature is 39-45 ℃, mixing speed is 50-70 rev/min, then in order successively with Mentholum, zinc oxide, boric acid, Sublimated Sulphur, salicylic acid, the Fel Anas domestica seed oil, laurocapram, glycerinum aluminis solution input is equipped with in the container of medical silicon cream mixes stirring, after stirring it is sent in the grinder and grind, after the grinding it is sent into emulsion tank and be emulsified into fine and smooth ointment, its medical silicon cream, Mentholum, zinc oxide, boric acid, Sublimated Sulphur, salicylic acid, the Fel Anas domestica seed oil, laurocapram, the weight ratio of glycerinum aluminis solution is 68-78:1.5-2.7:6.5-7.6:1.5-2.7:6.5-7.6:0.5-1.8:0.5-1.5:0. 5-1.5:3.5-5.2.
Above-mentioned said Mentholum replaces with Oleum menthae or Borneolum Syntheticum or Camphora, and said Sublimated Sulphur replaces with precipitated sulfur, and said glycerinum aluminis solution is the glycerinum aluminis solution that contains Alumen 8-12%.
The present invention and background technology relatively because former rosacea ointment is improved, therefore, have not only improved curative effect, and it is little to have had a drug reaction side effect, and pharmaceutical properties is good, and the patient is with advantages such as aftersensation are comfortable.
Embodiment
The present invention is further described below by specific embodiment.。
Embodiment
To not have impurity Sublimated Sulphur, zinc oxide, boric acid, salicylic acid, put into drying baker and carry out drying, grind respectively with mortar dry back, sieves sieving for standby with 120 order medicines respectively after the grinding.Mentholum is put into mortar, and to carry out porphyrize standby.Take by weighing 10 grams after will Alumen grinding, and put it in the glass container that 90 gram glycerol are housed and stir, and after the stirring, glass container be put into hot water make Alumen and glycerol dissolve into 10% glycerinum aluminis solution, cool its taking-up standby then.In the container that has heating and stir, drop into 745 gram medical silicon creams and heat and stir, heating and temperature control is at 42 ℃, mixing speed is 60 rev/mins, then in order successively with 24 gram Mentholums, 70 gram zinc oxide, 24 gram boric acid, 70 gram liters China sulfur, 10 gram salicylic acid, 10 gram Fel Anas domestica seed oils, 10 gram laurocapram, 47 gram glycerinum aluminis solution inputs are equipped with in the container of medical silicon cream mixes stirring, after stirring it is sent in the colloid mill and grind, after the grinding it is sent into emulsion tank and be emulsified into fine and smooth ointment, then holding vessel is put in the ointment taking-up and sealed up for safekeeping to be checked.By behind national drug standards WS-10001-(HD-0193)-2002 check character standardization, carry out the branch packing.
Claims (1)
1, a kind of treatment human face acarodermatitis medicine, it is characterized in that it is prepared by following method, in the container that has heating and stir, drop into medical silicon cream and heat and stir, heating-up temperature is 39-45 ℃, mixing speed is 50-70 rev/mins, then in order successively with Mentholum, zinc oxide, boric acid, Sublimated Sulphur, salicylic acid, the Fel Anas domestica seed oil, laurocapram, glycerinum aluminis solution input is equipped with in the container of medical silicon cream mixes stirring, after stirring it is sent in the grinder and grind, after the grinding it is sent into emulsion tank and be emulsified into fine and smooth ointment, its medical silicon cream, Mentholum, zinc oxide, boric acid, Sublimated Sulphur, salicylic acid, the Fel Anas domestica seed oil, laurocapram, the proportion of glycerinum aluminis solution is 68-78:1.5-2.7:6.5-7.6:1.5-2.7:6.5-7.6:0.5-1.8:0.5-1.5:0.5-1.5:3.5-5.2, and wherein said glycerinum aluminis solution is the glycerinum aluminis solution that contains Alumen 8-12%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100486330A CN100512878C (en) | 2005-11-18 | 2005-11-18 | Medicament for treating acarodermatitis of human face and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100486330A CN100512878C (en) | 2005-11-18 | 2005-11-18 | Medicament for treating acarodermatitis of human face and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101317862A CN101317862A (en) | 2008-12-10 |
| CN100512878C true CN100512878C (en) | 2009-07-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100486330A Active CN100512878C (en) | 2005-11-18 | 2005-11-18 | Medicament for treating acarodermatitis of human face and preparation method thereof |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921051A (en) * | 2012-09-04 | 2013-02-13 | 尹运贵 | Formula and preparation of mite removing patch |
| CN109528756A (en) * | 2017-09-21 | 2019-03-29 | 扬中牧乐药业有限公司 | A kind of sulfur ointment for treating mink mange and scab |
| CN111920757B (en) * | 2020-09-23 | 2021-05-11 | 杭州伊瑟奇生物科技有限公司 | Purification liquid for treating acarid dermatitis based on synergy of bioactive colloidal sulfur nanoparticles and methionine salt |
| CN113318146A (en) * | 2021-06-08 | 2021-08-31 | 高家伟 | Sulfur paste and using method thereof |
| CN114917268A (en) * | 2022-05-30 | 2022-08-19 | 厦门医肤康生物有限公司 | External medicine for treating acne rosacea, acne and seborrheic dermatitis and preparation method thereof |
-
2005
- 2005-11-18 CN CNB2005100486330A patent/CN100512878C/en active Active
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Effective date of registration: 20240408 Address after: No. 20-1-4-1, Tonghe Lane, Dalian Economic and Technological Development Zone, Liaoning Province, 116602 Patentee after: Zhao Jun Country or region after: China Address before: 650051, Jintai building, No. 48 Dongfeng Dong Road, Panlong District, Yunnan, Kunming 1104 Patentee before: Zhao Zhongzhou Country or region before: China |