CN101664036A - Cyromazine liquid preparation and preparation method thereof - Google Patents
Cyromazine liquid preparation and preparation method thereof Download PDFInfo
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- CN101664036A CN101664036A CN200910065941A CN200910065941A CN101664036A CN 101664036 A CN101664036 A CN 101664036A CN 200910065941 A CN200910065941 A CN 200910065941A CN 200910065941 A CN200910065941 A CN 200910065941A CN 101664036 A CN101664036 A CN 101664036A
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- cyromazine
- liquid preparation
- preparation
- antioxidant
- dispersion medium
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Abstract
The invention discloses a cyromazine liquid preparation comprising the following components: 1-10 percent (W/V) of cyromazine, 5-30 percent (W/V) of stabilizer, 0-10 percent (W/V) of cosolvent, 0.1-1percent (W/V) of antioxidant and 100 percent (W/V) of dispersion medium. The invention also discloses a preparation method of the cyromazine liquid preparation. The cyromazine liquid preparation is asolution and the cyromazine in the solution can kill screwworms, stop screwworms from propagating in animal stalls, thereby improving the growing environment of animals. The cyromazine liquid preparation can be mixed with feed or drinking water and the greatly-improved degree of uniformity degree of mixture is greatly improved in comparison with matched feed; and the cyromazine liquid preparationdoes not influence the pesticide effect of the cyromazine; in addition, the cyromazine liquid preparation is convenient to use.
Description
Technical field
The present invention relates to a kind of cyromazine liquid preparation, also relate to a kind of preparation method of said preparation.
Background technology
Cyromazine is a kind of efficient insect growth regulator, IGR, when the insect bodies intensive amount is higher than normal amount, larva and the pupa that can lure dipteral insect into distort on form, cause adult eclosion complete or suppressed, therefore can have killing action to the larva of dipteral insect, especially the several frequently seen larva such as the fly maggot of breeding there are good restraining and killing action in ight soil, the breeding of fly larva in the major control animal mew.The difference of cyromazine and general fly eradication medicine is that it only kills larva--fly maggot, and general fly eradication medicine only kills into fly and toxicity is bigger.After cyromazine entered in the animal body, the overwhelming majority (about 99%) excreted with ight soil with the form of original shape and metabolite thereof, thereby kills fly maggot in ight soil, and can not produce bigger influence to animal.Aspect the cyromazine preparation, mainly based on 1% cyromazine pre-mixing agent, 10% cyromazine pre-mixing agent, pre-mixing agent is mainly used in the spice of feed, and is very inconvenient in use at present, and the inhomogeneous meeting of spice influence drug effect.
Summary of the invention
The purpose of this invention is to provide a kind of cyromazine liquid preparation, to improve the uniformity of spice.
Another object of the present invention provides a kind of preparation method of cyromazine liquid preparation.
In order to realize above purpose, the technical scheme that cyromazine liquid preparation of the present invention is adopted is: a kind of cyromazine liquid preparation, said preparation is composed of the following components: cyromazine 1-10% (W/V), stabilizing agent 5-30% (W/V), cosolvent 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
Described stabilizing agent is a kind of or its any combination in polyethylene glycol, polyvinylpyrrolidone, the alpha-pyrrolidone.
Described cosolvent is a kind of or its any combination in sodium salicylate, the NN-dimethylacetylamide.
Described antioxidant is sulfur-bearing dvielement antioxidant, perhaps sulfur-bearing dvielement antioxidant and edta salt class, and wherein the edta salt class comprises the EDTA disodium salt, EDTA calcium salt etc.
Described sulfur-bearing dvielement antioxidant is sodium sulphite.
Described dispersion medium is water, ethanol, 1, a kind of or its any combination wherein of 2-propane diols, glycerine.
The preferred scheme of cyromazine of the present invention (1) is: said preparation is composed of the following components: cyromazine 1-10% (W/V), polyethylene glycol or alpha-pyrrolidone or polyvinylpyrrolidone 5-30% (W/V), sodium salicylate and/or NN-dimethylacetylamide 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
The preferred scheme of cyromazine of the present invention (2) is: said preparation is composed of the following components: cyromazine 1-10% (W/V), polyethylene glycol 3-15% (W/V), polyvinylpyrrolidone 2-15% (W/V), sodium salicylate and/or NN-dimethylacetylamide 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
The preferred scheme of cyromazine of the present invention (3) is: said preparation is composed of the following components: cyromazine 1-10% (W/V), polyethylene glycol 3-15% (W/V), alpha-pyrrolidone 2-15% (W/V), sodium salicylate and/or NN-dimethylacetylamide 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
The technical scheme that preparation method of the present invention adopted is: the step of this method is as follows: at first get antioxidant and add part dispersion medium heating for dissolving, add stabilizing agent, cosolvent and cyromazine heating for dissolving again, the pH value of regulating mixed liquor at last is 6.5-7.5, and the dispersion medium that adds surplus is made the cyromazine liquid preparation.
Cyromazine liquid preparation of the present invention, the cyromazine that wherein contains can be killed harmful fly larva, stop the breeding of fly larva in the animal mew, improve the environment of growth of animal; Stabilizing agent and cosolvent can improve the dissolubility of cyromazine in dispersion medium, are stable being dispersed in uniformly in the dispersion medium of cyromazine; Antioxidant can guarantee that cyromazine is difficult for oxidized material and destroys, and prevents to go bad.Cyromazine liquid preparation of the present invention in addition is a solution morphology, can mix with feed or drinking-water in use, and the uniformity of mixing improves greatly than spice, can not influence the drug effect of cyromazine, and is easy to use.
Embodiment
Embodiment 1
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get EDTA-2Na 0.05g, sodium sulphite 0.2g and add 40ml water heating for dissolving, add alpha-pyrrolidone 5g, NN-dimethylacetylamide 5g, cyromazine 1g, heating for dissolving, regulator solution pH6.5, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 2
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get EDTA-2Na 0.05g, sodium sulphite 0.2g and add 40ml water heating for dissolving, add polyvinylpyrrolidone 15g, cyromazine 1g heating for dissolving again, regulate PH6.7, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 3
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get sodium sulphite 0.1g and add 40ml water heating for dissolving, add alpha-pyrrolidone 10g, polyethylene glycol 10g, sodium salicylate 1g, cyromazine 5g heating for dissolving again, regulate PH6.9, add ethanol 15g, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 4
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get sodium sulphite 0.5g and add 40ml water heating for dissolving, add polyvinylpyrrolidone 15g, polyethylene glycol 10g, sodium salicylate 5g, cyromazine 10g heating for dissolving again, regulate PH7.2, add 1,2-propane diols 15g, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 5
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get sodium sulphite 1g and add 40ml water heating for dissolving, add alpha-pyrrolidone 15g, polyethylene glycol 15g, NN-dimethylacetylamide 5g, sodium salicylate 5g, cyromazine 10g heating for dissolving again, regulate PH7.5, add glycerine 15g, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 6
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get sodium sulphite 1g and add 40ml water heating for dissolving, add alpha-pyrrolidone 2g, polyethylene glycol 3g, NN-dimethylacetylamide 5g, sodium salicylate 5g, cyromazine 5g heating for dissolving again, regulate PH7.2, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 7
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get sodium sulphite 1g and add 40ml water heating for dissolving, add polyethylene glycol 15g again, polyvinylpyrrolidone 2g, NN-dimethylacetylamide 5g, sodium salicylate 5g, cyromazine 5g heating for dissolving are regulated PH7.2, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Embodiment 8
The component and the preparation method of the cyromazine liquid preparation of present embodiment are as follows:
Get sodium sulphite 1g and add 40ml water heating for dissolving, add polyethylene glycol 15g again, polyvinylpyrrolidone 10g, NN-dimethylacetylamide 5g, sodium salicylate 5g, cyromazine 5g heating for dissolving are regulated PH7.2, supplementing water to liquor capacity is 100ml, makes the cyromazine liquid preparation.
Claims (10)
1, a kind of cyromazine liquid preparation, it is characterized in that: said preparation is composed of the following components: cyromazine 1-10% (W/V), stabilizing agent 5-30% (W/V), cosolvent 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
2, cyromazine liquid preparation according to claim 1 is characterized in that: described stabilizing agent is a kind of or its any combination in polyethylene glycol, polyvinylpyrrolidone, the alpha-pyrrolidone.
3, cyromazine liquid preparation according to claim 1 is characterized in that: described cosolvent is a kind of or its any combination in sodium salicylate, the NN-dimethylacetylamide.
4, cyromazine liquid preparation according to claim 1 is characterized in that: described antioxidant is sulfur-bearing dvielement antioxidant, perhaps sulfur-bearing dvielement antioxidant and edta salt class.
5, cyromazine liquid preparation according to claim 4 is characterized in that: described sulfur-bearing dvielement antioxidant is sodium sulphite.
6, cyromazine liquid preparation according to claim 1 is characterized in that: described dispersion medium is water, ethanol, 1, a kind of or its any combination wherein of 2-propane diols, glycerine.
7, according to the arbitrary described cyromazine liquid preparation of claim 2-6, it is characterized in that: said preparation is composed of the following components: cyromazine 1-10% (W/V), polyethylene glycol or alpha-pyrrolidone or polyvinylpyrrolidone 5-30% (W/V), sodium salicylate and/or NN-dimethylacetylamide 0-10% (W/V), antioxidant 0.1-1%, dispersion medium to 100% (V/V).
8, according to the arbitrary described cyromazine liquid preparation of claim 2-6, it is characterized in that: said preparation is composed of the following components: cyromazine 1-10% (W/V), polyethylene glycol 3-15% (W/V), polyvinylpyrrolidone 2-15% (W/V), sodium salicylate and/or NN-dimethylacetylamide 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
9, according to the arbitrary described cyromazine liquid preparation of claim 2-6, it is characterized in that: said preparation is made up of following components in weight percentage: cyromazine 1-10% (W/V), polyethylene glycol 3-15% (W/V), alpha-pyrrolidone 2-15% (W/V), sodium salicylate and/or NN-dimethylacetylamide 0-10% (W/V), antioxidant 0.1-1% (W/V), dispersion medium to 100% (V/V).
10, a kind of preparation method of preparation according to claim 1, it is characterized in that: the step of this method is as follows: at first get antioxidant and add part dispersion medium heating for dissolving, add stabilizing agent, cosolvent and cyromazine heating for dissolving again, the pH value of regulating mixed liquor at last is 6.5-7.5, and the dispersion medium that adds surplus is made the cyromazine liquid preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910065941A CN101664036A (en) | 2009-08-26 | 2009-08-26 | Cyromazine liquid preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910065941A CN101664036A (en) | 2009-08-26 | 2009-08-26 | Cyromazine liquid preparation and preparation method thereof |
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| CN101664036A true CN101664036A (en) | 2010-03-10 |
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| CN200910065941A Pending CN101664036A (en) | 2009-08-26 | 2009-08-26 | Cyromazine liquid preparation and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614764A (en) * | 2016-12-15 | 2017-05-10 | 佛山市正典生物技术有限公司 | Fly killing agent containing macleaya cordata and cyromazine |
| CN109939067A (en) * | 2019-04-11 | 2019-06-28 | 厦门汇承科技有限公司 | Water-soluble cyromazine pre-mixing agent for animals of one kind and preparation method thereof |
| WO2019200929A1 (en) * | 2018-04-20 | 2019-10-24 | 刘长德 | Cyromazine urea particles and preparation method therefor |
| CN110951638A (en) * | 2019-11-28 | 2020-04-03 | 北斗星量子生物医药科技(深圳)有限公司 | Composite microbial agent for treating hazardous waste containing heavy metals and treatment method |
-
2009
- 2009-08-26 CN CN200910065941A patent/CN101664036A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614764A (en) * | 2016-12-15 | 2017-05-10 | 佛山市正典生物技术有限公司 | Fly killing agent containing macleaya cordata and cyromazine |
| WO2019200929A1 (en) * | 2018-04-20 | 2019-10-24 | 刘长德 | Cyromazine urea particles and preparation method therefor |
| CN109939067A (en) * | 2019-04-11 | 2019-06-28 | 厦门汇承科技有限公司 | Water-soluble cyromazine pre-mixing agent for animals of one kind and preparation method thereof |
| CN110951638A (en) * | 2019-11-28 | 2020-04-03 | 北斗星量子生物医药科技(深圳)有限公司 | Composite microbial agent for treating hazardous waste containing heavy metals and treatment method |
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Application publication date: 20100310 |