CN101658168B - Effervescent tablet of plant growth regulator composition and preparation method thereof - Google Patents
Effervescent tablet of plant growth regulator composition and preparation method thereof Download PDFInfo
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- CN101658168B CN101658168B CN 200910092052 CN200910092052A CN101658168B CN 101658168 B CN101658168 B CN 101658168B CN 200910092052 CN200910092052 CN 200910092052 CN 200910092052 A CN200910092052 A CN 200910092052A CN 101658168 B CN101658168 B CN 101658168B
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Abstract
The invention discloses an effervescent tablet of a plant growth regulator composition and a preparation method thereof. The effervescent tablet of the plant growth regulator composition is made of the raw materials including the substances based on the parts by mass: 0.1-30 parts of diethyl aminoethyl hexanoate, 0.1-60 parts of mepiquat chloride, more than 0 part and less than or equal to 40 parts of water-blocking agent, 3-30 parts of acidic effervescence agent, 3-30 parts of alkaline effervescence agent, 1-10 parts of binding agent and 1-20 parts of glidant. The effervescent tablet can be prepared by a direct drying tabletting method or a wet granulation and secondary tabletting method, wherein the direct drying tabletting method can be used for preparing the effervescent tablet by mechanically grinding auxiliary agent, evenly mixing the auxiliary agent and two active components and directly tabletting; and the wet granulation and secondary tabletting method can be used for preparing the effervescent tablet by drying the two active components, grinding the auxiliary agent, preparing acidic and alkaline soft materials by mixing, bonding and pelleting, and finally tabletting. The water-blocking agent is introduced to solve the problem of moisture absorption of active ingredient solid preparation of mepiquat chloride; furthermore, the prepared mepiquat chloride composition effervescent tablet of the plant growth regulator diethyl aminoethyl hexanoate is a new formulation product having the characteristics of rapid disintegration, completely dissolving out of the active ingredient and accurate and quantitative field operation.
Description
Technical field
The present invention relates to effervescent tablet of plant growth adjustment composition and preparation method thereof.
Background technology
In agricultural production, lodging and volume increase are the common Main Problems of crop such as cotton, soybean, peanut, rape at present.
Patent ZL 03118724.2 has reported that a kind of diethylamino ethanol caproate and first piperazine of containing is as the plant growth regulator composition of active component, said composition can effectively prevent the plant lodgings such as soybean, cotton, effect of increasing production is good, improve quality obvious, and production technology is simple, and is easy to use.
Diethylamino ethanol caproate, general diethyl aminoethyl hexanoate by name is novel plant metabolism conditioning agent, diethyl aminoethyl hexanoate can promote the crop seedling growth, strengthens photosynthesis and substance operation, promotes cotton boll, pod Isoquant allelotaxis.First piperazine, commodity are called casing coupling peace, Pix, help strong element etc., are a kind of plant growth regulator of interior absorption, can promote that the chlorophyll of plant is synthetic, and the elongation of control stipes prevents spindling, and make plant type compact, short strong; Can increase output, improve quality, be a widely used class conditioning agent in the current agricultural production.
At present, to contain the plant growth regulator composition product of diethyl aminoethyl hexanoate and first piperazine be aqua formulation (LS20090604,27.5% diethyl aminoethyl hexanoate first piperazine aqua) for China registration; Because these two kinds of active ingredient good water solubility also can be processed into soluble powder.But, owing to the former medicine of first piperazine very easily the moisture absorption deliquescence cause composition to lose commodity value, less to effective ingredient consumption in early days in plant growth on the other hand, in field when operation, be difficult to accurate quantitative analysis and easily cause poisoning, brings loss to agricultural production; Also there is certain difficulty in aqua product at stable effective ingredients, field operation accurate quantitative analysis.
Summary of the invention
The purpose of this invention is to provide effervescent tablet of a kind of plant growth regulator composition and preparation method thereof.
The effervescent tablet of plant growth regulator composition provided by the present invention, the raw material of making it comprises the material of following mass parts: diethyl aminoethyl hexanoate 0.1-30, first piperazine 0.1-60, waterproofing agent greater than 0 less than or equal to 40, acid effervescent agent 3-30, alkaline effervescent agent 3-30, binding agent 1-10 and glidant 1-20.
The raw material of making described effervescent tablet also can comprise filler, and the mass parts of described filler is less than or equal to 90 greater than 0.
Certainly, described plant growth regulator composition effervescent tablet also can only be made by the material of following mass parts: diethyl aminoethyl hexanoate 0.1-30, first piperazine 0.1-60, waterproofing agent greater than 0 less than or equal to 40, acid effervescent agent 3-30, alkaline effervescent agent 3-30, binding agent 1-10 and glidant 1-20; Perhaps only made by the material of following mass parts: diethyl aminoethyl hexanoate 0.1-30, first piperazine 0.1-60, waterproofing agent be greater than 0 less than or equal to 40, acid effervescent agent 3-30, alkaline effervescent agent 3-30, binding agent 1-10, glidant 1-20 and filler greater than 0 less than or equal to 90.
Among the present invention, described waterproofing agent is selected from least a in following 5 kinds of materials: calcium monohydrogen phosphate, calcium carbonate, bentonite, diatomite and alundum (Al2O3), preferred calcium carbonate and/or calcium monohydrogen phosphate;
Described acid effervescent agent is selected from least a in following 3 kinds of materials: citric acid, tartaric acid and oxalic acid, optimization citric acid and/or tartaric acid;
Described alkaline effervescent agent is selected from least a in following 4 kinds of materials: sodium carbonate, sodium bicarbonate, potash and saleratus, preferred sodium bicarbonate and/or saleratus;
Described binding agent is selected from least a in following 3 kinds of materials: polyethylene glycol (mean molecule quantity is 5000-15000), lactose and carboxymethyl cellulose; Preferably carboxymethyl cellulose and/or polyethylene glycol;
Described glidant is selected from following 4 at least a in the material: stearic acid, calcium stearate, dolomol and talcum powder; Preferably talc powder and/or stearic acid.
Described filler is selected from least a in following 6 kinds of materials: starch, kaolin, bentonite and white carbon; Preferred bentonite and/or kaolin.
The invention provides two kinds of methods that prepare described plant growth regulator composition effervescent tablet, i.e. direct compressing dry granulation and wet granulation compressing tablet again.
Concrete preparation method is as follows:
1, direct compressing dry granulation method comprises the steps:
The acid effervescent agent, alkaline effervescent agent, waterproofing agent, binding agent, glidant and the filler that form the described mass parts of effervescent tablet are pulverized, drying is carried out in diethyl aminoethyl hexanoate, the acid of first piperazine of described mass parts;
2) will be through step 1) behind all raw material blendings of processing, direct compressing dry granulation namely gets the effervescent tablet of plant growth regulator composition.
Wherein, the method that described acid effervescent agent and alkaline effervescent agent are pulverized is mechanical crushing method, and the particle diameter of described acid effervescent agent and alkaline effervescent agent is the 800-1000 order after pulverizing; The method that described waterproofing agent, binding agent, glidant and filler are pulverized is comminution by gas stream, and the particle diameter of described waterproofing agent, binding agent, glidant and filler is the 800-1000 order after pulverizing.
2, pressed disc method again behind the wet granulation comprises the steps:
1) preparation acid particles and alkali grain;
Described acid particles and alkali grain prepare by the following method:
(a) described filler is divided into two parts according to the mass ratio of described acid effervescent agent and alkaline effervescent agent, i.e. the filler filler corresponding with alkaline effervescent agent corresponding to acid effervescent agent; After pulverizing, the filler that described acid effervescent agent is corresponding with the described diethyl aminoethyl hexanoate mixing of drying, gets material A; The filler that described alkaline effervescent agent is corresponding and described waterproofing agent are pulverized after mixing, and then with the described first piperazine mixing of drying, get material B;
(b) with after described acid effervescent agent, the pulverizing of alkaline effervescent agent, add respectively among described material A and the material B, all add binding agent behind the mixing, make respectively acid softwood and alkaline softwood after mixing again;
(c) described acid softwood and alkaline softwood are granulated respectively, dry, whole grain gets acid particles and alkali grain;
2) described acid particles and alkali grain are mixed to get mixture, add described glidant in described mixture, behind the mixing, compressing tablet namely gets the effervescent tablet of plant growth regulator composition.
Wherein, the method that described acid effervescent agent and alkaline effervescent agent are pulverized is mechanical crushing method, and the particle diameter of described acid effervescent agent and alkaline effervescent agent is the 80-100 order after pulverizing; The method that described dispersant, filler, waterproofing agent, binding agent and glidant are pulverized is comminution by gas stream, and the particle diameter of described waterproofing agent, binding agent, dispersant, glidant and filler is the 800-1000 order after pulverizing.
Being shaped as of the effervescent tablet of the plant growth regulator composition that the present invention is prepared circular or irregularly shaped (as: oval, rhombus), every weight is counted: 0.5 gram-5.0 grams.
The invention provides a kind of effervescent tablet that contains diethyl aminoethyl hexanoate and first piperazine, solved the hygroscopicity problem of the solid pharmaceutical preparation that contains the first piperazine in this tablet by introducing waterproofing agent.Result of the test shows, effervescent tablet of the present invention have disintegration rapidly, the sufficient advantage of active ingredient stripping; Compare with aqua with traditional soluble powder, in the operation of field, can to the active ingredient accurate quantitative analysis, reduce poisoning and occur.
Description of drawings
Fig. 1 is the production technological process that the present invention adopts the standby product of direct compressing dry granulation legal system.
Fig. 2 is that the present invention adopts the again production technological process of pressed disc method preparing product of wet granulation.
Embodiment
The Preparation Example of lower mask body and application test embodiment only make detailed description to the present invention, but do not limit the present invention.
Experimental technique described in the following embodiment if no special instructions, is conventional method; Described reagent and material if no special instructions, all can obtain from commercial channels.
The preparation of embodiment 1 0.2% diethyl aminoethyl hexanoate first piperazine effervescent tablet
The former powder of 97.0% first piperazine (following examples are same) that the former powder of 98.0% diethyl aminoethyl hexanoate that former medicine diethyl aminoethyl hexanoate selects Zhengzhou, henan Zheng Shi chemical industry Co., Ltd to produce, former medicine first piperazine select changzhou city south of the River insecticide factory to produce.
Former medicine and auxiliary agent are selected and proportioning is: former medicine 0.102 mass parts of 98% diethyl aminoethyl hexanoate (pure 0.1 mass parts), former medicine 0.104 mass parts of 97.0% first piperazine (pure 0.1 mass parts), waterproofing agent diatomite 0.1 mass parts, acid effervescent agent oxalic acid 30.0 mass parts, alkaline effervescent agent sodium bicarbonate 30.0 mass parts, binding agent lactose 3.0 mass parts, glidant talcum powder 5.0 mass parts, filler white carbon 31.694 mass parts.
To prepare 10 kilograms of samples, calculate respectively each amounts of components, weighing by above proportioning.Standby by direct compressing dry granulation legal system, method is as follows:
(1) 0.0104 kilogram of 0.0102 kilogram of diethyl aminoethyl hexanoate, first piperazine, are packed respectively after 24 hours 80 ℃ of oven dry;
(2) with 3.00 kilograms of oxalic acid, 3.00 kilograms of mechanical crushing of sodium bicarbonate to 100 orders, 0.01 kilogram in diatomite, 0.30 kilogram of lactose, 3.1694 kilograms of white carbons and 0.50 kilogram of mixing and stirring of talcum powder, air-flow crushing is to 800 orders, stir in mixing and blending machine with 0.0104 kilogram of 0.0102 kilogram of diethyl aminoethyl hexanoate, first piperazine and to be pressed into effervescent tablet after 10 minutes, pack and get product.
Carry out product according to the effervescent tablet quality control index and detect, index includes effective component content (stripping), disintegration time, pH scope and heat storage stability etc.Concrete grammar is as follows:
Get and make 1 in tablet, the w that accurately weighs to get puts into the band plug graduated cylinder that 250 milliliters of standard hard water are housed, the whole disintegration required times of record tablet; After leaving standstill 30 minutes, get supernatant liquor according to measure first piperazine content X% with HG 2857-1997 method, use the gas chromatograph with hydrogen flame ionization detector to detect diethyl aminoethyl hexanoate content Y%.
Take by weighing 1.0 gram samples and pour the band plug graduated cylinder that 100 milliliters of standard hard water are housed into, fully after the disintegration, measure the pH scope with pH meter;
The sample that takes by weighing certain mass packs, and places 14 days for 54 ℃, carries out above-mentioned quality control index evaluation, calculates active ingredient heat storage resolution ratio.
Every weight of the effervescent tablet that makes is 1.0 grams, diethyl aminoethyl hexanoate stripping content 0.0995% (dissolution rate 99.5%), first piperazine stripping content 0.0994% (dissolution rate 99.4%).
The hygroscopicity of effervescent tablet characterizes with hydroscopicity, estimates the hygroscopicity of first piperazine effervescent tablet with reference to the mensuration (QB/T1941.5-94) of fireworks and firecrackers medicament hydroscopicity, and concrete grammar is as follows:
Accurately take by weighing 1 gram left and right sides sample (w
1), put into dried and clean and the (w that weighs
2) in the measuring cup of 3 centimetres of diameters, evenly spread out to the bottom, do not add a cover; Measuring cup is put into saturated calcium nitrate solution drier (keeping humidity 55%) is housed, and with the vaseline sealing, places 20 ℃ of insulating boxs; Take by weighing the gross weight (w of measuring cup and sample after 24 hours
3), calculate weightening finish percentage (%)=(w
3-(w
1+ w
2))/w
1* 100%, namely get hydroscopicity (97% first piperazine soluble powder hydroscopicity is 25.8% under this experimental condition).
This effervescent tablet hydroscopicity 0.1%, disintegration time is 85 seconds in water, and heat storage stability is qualified, diethyl aminoethyl hexanoate resolution ratio 0.5%, first piperazine resolution ratio 0.6%.
The preparation of embodiment 2 20% diethyl aminoethyl hexanoate first piperazine effervescent tablets
Former medicine and auxiliary agent are selected and proportioning is: former medicine 15.3 mass parts of 98% diethyl aminoethyl hexanoate (pure 15.0 mass parts), former medicine 5.2 mass parts of 97.0% first piperazine (pure 5.0 mass parts), waterproofing agent calcium carbonate 5.0 mass parts, acid effervescent agent citric acid 10.0 mass parts, alkaline effervescent agent saleratus 10.0 mass parts, binding agent carboxymethyl cellulose 3.0 mass parts, glidant calcium stearate 5.0 mass parts, filler kaolin 46.5 mass parts.
To prepare 10 kilograms of samples, calculate respectively each amounts of components, weighing by above proportioning.Press again pressed disc method preparation of wet granulation, method is as follows:
(1) 0.52 kilogram of 1.53 kilograms of diethyl aminoethyl hexanoate, first piperazine, are packed respectively after 24 hours 50 ℃ of oven dry;
(2) with 2.325 kilograms of air-flow crushings of kaolin to 1000 orders, stir in mixing and blending machine with 1.53 kilograms of diethyl aminoethyl hexanoates and to pack to get material A in 10 minutes; With 0.50 kilogram in calcium carbonate, 2.325 kilograms of mixing and stirring of kaolin, air-flow crushing stirred in mixing and blending machine 10 minutes with the first piperazine to 1000 orders, packed to get material B;
(3) with 1.00 kilograms of citric acids, 1.00 kilograms of mechanical crushing of saleratus to 100 orders, 0.50 kilogram of air-flow crushing of calcium stearate is to 1000 orders, respectively independent packing;
(4) with the material A of (2) preparation, the citric acid that adds pulverizing stirs in mixing and blending machine and adds 0.15 kilogram of carboxymethyl cellulose after 10 minutes, mixes 10 minutes again, makes acid softwood; With the material B of (2) preparation, the saleratus that adds pulverizing stirs in mixing and blending machine and adds 0.15 kilogram of carboxymethyl cellulose after 10 minutes, mixes 10 minutes again, makes alkaline softwood;
(5) two kinds of softwoods that make in (4) are inserted granulate in the granulator respectively, 45 ℃ be dried to moisture less than 2% after, through the whole grain of 20 mesh sieves acid particles and alkali grain, pack respectively;
(6) 5.005 kilograms of acid particleses, the alkali grain 4.495 that makes in (5) added in the mixer, add calcium stearate, mix and blend is compressing tablet after 10 minutes, is pressed into effervescent tablet, packs to get product.
Every weight of the effervescent tablet that makes 1.0 grams, diethyl aminoethyl hexanoate stripping content 14.91% (dissolution rate 99.4%), first piperazine stripping content 4.99% (dissolution rate 99.8%).
This effervescent tablet hydroscopicity 0.3%, disintegration time is 65 seconds in water, and heat storage stability is qualified, diethyl aminoethyl hexanoate resolution ratio 0.3%, first piperazine resolution ratio 0.5%.
The preparation of embodiment 3,27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet
Former medicine and auxiliary agent are selected and proportioning is: former medicine 2.6 mass parts of 98% diethyl aminoethyl hexanoate (pure 2.5 mass parts), former medicine 25.8 mass parts of 97.0% first piperazine (pure 25.0 mass parts), waterproofing agent calcium monohydrogen phosphate 10.0 mass parts, acid effervescent agent tartaric acid 12.0 mass parts, alkaline effervescent agent potash 8.0 mass parts, binding agent polyethylene glycol 3.0 mass parts, glidant dolomol 3.0 mass parts, filler bentonite 35.6 mass parts.
Calculate respectively each amounts of components, weighing by above proportioning.Standby by direct compressing dry granulation legal system, detailed process is with embodiment 1.
Every weight of the effervescent tablet that makes 3.0 grams, diethyl aminoethyl hexanoate stripping content 2.46% (dissolution rate 98.5%), first piperazine stripping content 24.75% (dissolution rate 99.0%).
This effervescent tablet hydroscopicity 1.5%, disintegration time is 85 seconds in water, and heat storage stability is qualified, diethyl aminoethyl hexanoate resolution ratio 0.5%, first piperazine resolution ratio 0.8%.
Embodiment 4 35% diethyl aminoethyl hexanoate first piperazine effervescent tablets
Former medicine and auxiliary agent are selected and proportioning is: former medicine 30.6 mass parts of 98% diethyl aminoethyl hexanoate (pure 30.0 mass parts), former medicine 5.2 mass parts of 97.0% first piperazine (pure 5.0 mass parts), waterproofing agent calcium monohydrogen phosphate 5.0 mass parts, acid effervescent agent citric acid 15.0 mass parts, alkaline effervescent agent potash 6.0 mass parts, binding agent polyethylene glycol 6.0 mass parts, glidant dolomol 3.0 mass parts, filler starch 29.2 mass parts.
Calculate respectively each amounts of components, weighing by above proportioning.Standby by direct compressing dry granulation legal system, detailed process is with embodiment 1.
Every weight of the effervescent tablet that makes 3.0 grams, diethyl aminoethyl hexanoate stripping content 29.4% (dissolution rate 98.0%), first piperazine stripping content 4.95% (dissolution rate 99.0%).
This effervescent tablet hydroscopicity 0.3%, disintegration time is 84 seconds in water, and heat storage stability is qualified, diethyl aminoethyl hexanoate resolution ratio 0.5%, first piperazine resolution ratio 0.8%.
The preparation of embodiment 5 40% diethyl aminoethyl hexanoate first piperazine effervescent tablets
Former medicine and auxiliary agent are selected and proportioning is: former medicine 3.8 mass parts of 98% diethyl aminoethyl hexanoate (pure 3.7 mass parts), former medicine 37.4 mass parts of 97.0% first piperazine (pure 36.3 mass parts), waterproofing agent calcium carbonate 10.0 mass parts, acid effervescent agent tartaric acid 8.0 mass parts, alkaline effervescent agent sodium carbonate 8.0 mass parts, binding agent lactose 2.0 mass parts, glidant stearic acid 3.0 mass parts, filler starch 27.8 mass parts.
Calculate respectively each amounts of components, weighing by above proportioning.Press again pressed disc method preparation of wet granulation, detailed process is with embodiment 2.
Every weight of the effervescent tablet that makes 2.0 grams, diethyl aminoethyl hexanoate stripping content 3.67% (dissolution rate 98.5%), first piperazine stripping content 35.86% (dissolution rate 98.8%).
This effervescent tablet hydroscopicity 1.9%, disintegration time is 65 seconds in water, and heat storage stability is qualified, diethyl aminoethyl hexanoate resolution ratio 0.4%, first piperazine resolution ratio 0.7%.
Embodiment 6 65% diethyl aminoethyl hexanoate first piperazine effervescent tablets
Former medicine and auxiliary agent are selected and proportioning is: former medicine 5.1 mass parts of 98% diethyl aminoethyl hexanoate (pure 5.0 mass parts), former medicine 61.9 mass parts of 97.0% first piperazine (pure 60.0 mass parts), waterproofing agent calcium monohydrogen phosphate 12.0 mass parts, acid effervescent agent oxalic acid 7.0 mass parts, alkaline effervescent agent saleratus 8.0 mass parts, binding agent polyethylene glycol 1.0 mass parts, glidant talcum powder 5.0 mass parts.
Calculate respectively each amounts of components, weighing by above proportioning.Press again pressed disc method preparation of wet granulation, detailed process is with embodiment 2.
Every weight of the effervescent tablet that makes 1.0 grams, diethyl aminoethyl hexanoate stripping content 4.95% (dissolution rate 99%), first piperazine stripping content 59.58% (dissolution rate 99.3%).
This effervescent tablet hydroscopicity 3.3%, disintegration time is 45 seconds in water, and heat storage stability is qualified, diethyl aminoethyl hexanoate resolution ratio 0.6%, first piperazine resolution ratio 0.4%.
Embodiment 7,27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet are regulated Insect Resistant Cotton growth field trial
Test period: 2007
Test site: proving ground, Haidian District, Beijing City China Agricultural University Liang Jia shop
Trial crops: pest-resistant cotton, kind are new cotton 99B
Test is processed: process in initial bloom stage, full-bloom stage and rear three foliar sprays of pinching, if three processing of 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet of clear water contrast, the contrast of 27.5% diethyl aminoethyl hexanoate first piperazine aqua medicament and embodiment 3 preparations, each processing arranges 4 repetitions, decide strain investigation cotton plant plant height, lint yield after the results, the results are shown in Table 1.
Wherein, initial bloom stage, full-bloom stage and pinch after 27.5% diethyl aminoethyl hexanoate first piperazine aqua when processing, every mu measures respectively 6.0 milliliters, 12.0 milliliters and 18.0 milliliters 30 kilograms in water is carried out foliar spray; Initial bloom stage, full-bloom stage and pinch after 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet (every heavy 3.0 gram) when processing, every mu is carried out foliar spray to 30 kilograms in water after getting respectively 2,4 and 6 dissolvings;
Table 1,27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet are to Insect Resistant Cotton growth regulating result of the test
The result shows, 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet of embodiment 3 preparations has good growth regulating effect to new cotton 99B, compares with contrast medicament 27.5% diethyl aminoethyl hexanoate first piperazine aqua, and is suitable to the control effect of plant height, larger to the gined cotton amount of increase in production.Simultaneously, this product field is easy to operate, can carry out accurate quantitative analysis, can guarantee regulating effect, can not cause the excessive excessive control that brings of spraying medicine concentration because of misoperation again.
Embodiment 8 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablets are regulated the peanut growth field trial
Test period: 2008
Test site: proving ground, Haidian District, Beijing City China Agricultural University Liang Jia shop
Trial crops: peanut, kind are that spend No. 11 the Shandong
Test is processed: carry out foliar spray in the floricome phase and process, if clear water contrast, the contrast of 27.5% diethyl aminoethyl hexanoate first piperazine aqua medicament and three processing of 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet, each processing arranges 4 repetitions, decides strain investigation plant plant height and seed benevolence output after the results, the results are shown in Table 2;
Wherein, when 27.5% diethyl aminoethyl hexanoate first piperazine aqua was processed, every mu measured 30 milliliters 30 kilograms in water is carried out foliar spray; When 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet (every heavy 3.0 gram) was processed, every mu was carried out foliar spray to 30 kilograms in water after getting 10 dissolvings.
Table 2 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet is to peanut growth adjusting test result
The result shows, 27.5% diethyl aminoethyl hexanoate first piperazine effervescent tablet of embodiment 3 preparations is spent the Shandong has good growth regulating effect No. 11, compares with contrast medicament 27.5% diethyl aminoethyl hexanoate first piperazine aqua, suitable to the regulating effect of plant height control and seed benevolence output.This product field is easy to operate, can carry out accurate quantitative analysis, can guarantee regulating effect, can not cause the excessive excessive control that brings of spraying medicine concentration because of misoperation again.
Embodiment 9 40% diethyl aminoethyl hexanoate first piperazine effervescent tablet field trials
Test period: 2008
Test site: proving ground, the village in the China Agricultural University of Haidian District, Beijing City
Trial crops: soybean, kind are middle yellow No. 4
Test is processed: process in the branching stage foliar spray, if 40% diethyl aminoethyl hexanoate first piperazine effervescent tablet of clear water contrast, the contrast of 80% diethyl aminoethyl hexanoate first piperazine soluble powder medicament and embodiment 4 preparations is processed, each processing arranges 4 repetitions, results " Invest, Then Investigate " base portion 1-3 joint overall length, grain yield the results are shown in Table 3;
Wherein, when 80% diethyl aminoethyl hexanoate first piperazine soluble powder was processed, every mu took by weighing 6.0 grams 30 kilograms in water is carried out foliar spray; When 40% diethyl aminoethyl hexanoate first piperazine effervescent tablet (every heavy 2.0 gram) was processed, every mu was carried out foliar spray to 30 kilograms in water after getting 6 dissolvings.
Table 3 40% diethyl aminoethyl hexanoate first piperazine effervescent tablet is to soybeans they grow adjusting test result
The result shows, 40% diethyl aminoethyl hexanoate first piperazine effervescent tablet centering of embodiment 4 preparations has good growth regulating effect yellow No. 4, compare with contrast medicament 80% diethyl aminoethyl hexanoate first piperazine soluble powder, control effect to plant height is more outstanding, increase to soybean kernel output is more remarkable, this is because the field operation of contrast medicament soluble powder is not easy to metering, and moisture absorption reason causes that substantial activity composition consumption is on the low side to be caused.
Claims (13)
1. the effervescent tablet of a plant growth regulator composition, the raw material of making it comprises the material of following mass parts: diethyl aminoethyl hexanoate 0.1-30, first piperazine 0.1-60, waterproofing agent greater than 0 less than or equal to 40, acid effervescent agent 3-30, alkaline effervescent agent 3-30, binding agent 1-10 and glidant 1-20;
Described waterproofing agent is selected from least a in following 5 kinds of materials: calcium monohydrogen phosphate, calcium carbonate, bentonite, diatomite and alundum (Al2O3);
Described acid effervescent agent is selected from least a in following 3 kinds of materials: citric acid, tartaric acid and oxalic acid;
Described alkaline effervescent agent is selected from least a in following 4 kinds of materials: sodium carbonate, sodium bicarbonate, potash and saleratus;
Described binding agent is selected from least a in following 3 kinds of materials: polyethylene glycol, lactose and carboxymethyl cellulose; The mean molecule quantity of described polyethylene glycol is 5000-15000;
Described glidant is selected from least a in following 4 kinds of materials: stearic acid, calcium stearate, dolomol and talcum powder.
2. effervescent tablet according to claim 1, it is characterized in that: described effervescent tablet is made by following mass parts material: diethyl aminoethyl hexanoate 0.1-30, first piperazine 0.1-60, waterproofing agent greater than 0 less than or equal to 40, acid effervescent agent 3-30, alkaline effervescent agent 3-30, binding agent 1-10 and glidant 1-20.
3. effervescent tablet according to claim 2, it is characterized in that: described effervescent tablet is made by following mass parts material: diethyl aminoethyl hexanoate 5, first piperazine 60, waterproofing agent 12, acid effervescent agent 7, alkaline effervescent agent 8, binding agent 1 and glidant 5.
4. effervescent tablet according to claim 1, it is characterized in that: the raw material of making described effervescent tablet also comprises filler, the mass parts of described filler is less than or equal to 90 greater than 0.
5. effervescent tablet according to claim 4, it is characterized in that: described effervescent tablet is made by the material of following mass parts: diethyl aminoethyl hexanoate 0.1-30, first piperazine 0.1-60, waterproofing agent greater than 0 less than or equal to 40, acid effervescent agent 3-30, alkalescence effervescent agent 3-30, binding agent 1-10, glidant 1-20 and filler greater than 0 less than or equal to 90.
6. effervescent tablet according to claim 5 is characterized in that:
Described effervescent tablet is by following 1)-4) in the material of arbitrary described mass parts make:
1) diethyl aminoethyl hexanoate 0.1, first piperazine 0.1, waterproofing agent 0.1, acid effervescent agent 30, alkaline effervescent agent 30, binding agent 3, glidant 5 and filler 31.694;
2) diethyl aminoethyl hexanoate 15, first piperazine 5, waterproofing agent 5, acid effervescent agent 10, alkaline effervescent agent 10, binding agent 3, glidant 5 and filler 46.5;
3) diethyl aminoethyl hexanoate 2.5, first piperazine 25, waterproofing agent 10, acid effervescent agent 12, alkaline effervescent agent 8, binding agent 3, glidant 3 and filler 36.5;
4) diethyl aminoethyl hexanoate 3.7, first piperazine 36.3, waterproofing agent 10, acid effervescent agent 8, alkaline effervescent agent 8, binding agent 2, glidant 3 and filler 27.8.
7. arbitrary described effervescent tablet according to claim 1-6, it is characterized in that: described waterproofing agent is selected from calcium carbonate and/or calcium monohydrogen phosphate;
Described acid effervescent agent is selected from citric acid and/or tartaric acid;
Described alkaline effervescent agent is selected from sodium bicarbonate and/or saleratus;
Described binding agent is selected from carboxymethyl cellulose and/or polyethylene glycol; The mean molecule quantity of described polyethylene glycol is 5000-15000;
Described glidant is selected from talcum powder and/or stearic acid.
8. arbitrary described effervescent tablet according to claim 4-6 is characterized in that: described filler is selected from least a in following 4 kinds of materials: starch, kaolin, bentonite and white carbon.
9. effervescent tablet according to claim 8, it is characterized in that: described filler is selected from bentonite and/or kaolin.
10. a method for preparing the effervescent tablet of the described plant growth regulator composition of claim 4 comprises the steps:
1) the acid effervescent agent of mass parts described in the claim 4, alkaline effervescent agent, waterproofing agent, binding agent, glidant and filler are pulverized, drying is carried out in diethyl aminoethyl hexanoate, the acid of first piperazine of described mass parts;
2) will be through step 1) behind all raw material blendings of processing, direct compressing dry granulation namely gets the effervescent tablet of plant growth regulator composition.
11. method according to claim 10 is characterized in that: the method that described acid effervescent agent and alkaline effervescent agent are pulverized is mechanical crushing method, and the particle diameter of described acid effervescent agent and alkaline effervescent agent is the 80-100 order after pulverizing; The method that described waterproofing agent, binding agent, glidant and filler are pulverized is comminution by gas stream, and the particle diameter of described waterproofing agent, binding agent, glidant and filler is the 800-1000 order after pulverizing.
12. a method for preparing the effervescent tablet of the described plant growth regulator composition of claim 4 comprises the steps:
1) preparation acid particles and alkali grain;
Described acid particles and alkali grain prepare by the following method:
(a) filler described in the claim 4 is divided into two parts according to the mass ratio of described acid effervescent agent and alkaline effervescent agent, i.e. the filler filler corresponding with alkaline effervescent agent corresponding to acid effervescent agent; After pulverizing, the filler that described acid effervescent agent is corresponding with the described diethyl aminoethyl hexanoate mixing of drying, gets material A; The filler that described alkaline effervescent agent is corresponding and described waterproofing agent are pulverized after mixing, and then with the described first piperazine mixing of drying, get material B;
(b) with after described acid effervescent agent, the pulverizing of alkaline effervescent agent, add respectively among described material A and the material B, all add binding agent behind the mixing, make respectively acid softwood and alkaline softwood after mixing again;
(c) described acid softwood and alkaline softwood are granulated respectively, dry, whole grain gets acid particles and alkali grain;
2) described acid particles and alkali grain are mixed to get mixture, add described glidant in described mixture, behind the mixing, compressing tablet namely gets the effervescent tablet of plant growth regulator composition.
13. method according to claim 12 is characterized in that: the method that described acid effervescent agent and alkaline effervescent agent are pulverized is mechanical crushing method, and the particle diameter of described acid effervescent agent and alkaline effervescent agent is the 80-100 order after pulverizing; The method that described dispersant, filler, waterproofing agent, binding agent and glidant are pulverized is comminution by gas stream, and the particle diameter of described waterproofing agent, binding agent, dispersant, glidant and filler is the 800-1000 order after pulverizing.
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101836629A (en) * | 2010-06-17 | 2010-09-22 | 陕西韦尔奇作物保护有限公司 | Plant growth regulator containing diethyl aminoethyl hexanoate |
| CN102173934B (en) * | 2011-01-25 | 2014-04-23 | 陕西汉唐环保农业有限公司 | Multi-nutrition growth regulator special for soybean and peanut |
| CN102246819B (en) * | 2011-05-19 | 2013-12-18 | 成都阳光生物科技有限责任公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
| CN102450259A (en) * | 2011-11-08 | 2012-05-16 | 安阳市全丰农药化工有限责任公司 | Diethyl aminoethyl hexanoate organic acid salt effervescent granule/effervescent tablet and preparation method thereof |
| CN102450264A (en) * | 2011-11-25 | 2012-05-16 | 安阳市全丰农药化工有限责任公司 | Mepiquat chloride water dispersible granule/tablet and preparation method thereof |
| CN103570439A (en) * | 2012-07-31 | 2014-02-12 | 天津绿动植物营养技术开发有限公司 | Plant nutritional agent in dosage form of effervescent tablet |
| CN104542708B (en) * | 2014-12-26 | 2017-10-17 | 郑州郑氏化工产品有限公司 | A kind of prosperous complex preparation resistant to lodging of leek control |
| CN107827245A (en) * | 2017-10-27 | 2018-03-23 | 华南理工大学 | A kind of efficiently Shui nationality water purification effervescent tablet and preparation method thereof |
| CN114920610B (en) * | 2022-06-07 | 2023-01-24 | 中国农业大学 | Effervescent tablet containing nitrification inhibitor and preparation method thereof |
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| CN1098591A (en) * | 1993-08-11 | 1995-02-15 | 北京市农林科学院作物研究所 | The production method of pollen plant growth regulator |
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