CN101657468B - 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 - Google Patents

用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 Download PDF

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Publication number
CN101657468B
CN101657468B CN200880011577.5A CN200880011577A CN101657468B CN 101657468 B CN101657468 B CN 101657468B CN 200880011577 A CN200880011577 A CN 200880011577A CN 101657468 B CN101657468 B CN 101657468B
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China
Prior art keywords
tshr
tsh
antibody
thyroid
cyclic amp
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CN200880011577.5A
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Chinese (zh)
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CN101657468A (zh
Inventor
B·瑞斯史密斯
J·福尔曼克
J·桑德斯
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RSR Ltd
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RSR Ltd
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Priority claimed from GB0702990A external-priority patent/GB0702990D0/en
Priority claimed from GB0714036A external-priority patent/GB0714036D0/en
Application filed by RSR Ltd filed Critical RSR Ltd
Priority claimed from PCT/GB2008/000518 external-priority patent/WO2008099185A1/en
Publication of CN101657468A publication Critical patent/CN101657468A/zh
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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880011577.5A 2007-02-15 2008-02-14 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 Active CN101657468B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US90133207P 2007-02-15 2007-02-15
GB0702990.3 2007-02-15
US60/901,332 2007-02-15
GB0702990A GB0702990D0 (en) 2007-02-15 2007-02-15 Products
GB0714036.1 2007-07-18
GB0714036A GB0714036D0 (en) 2007-07-18 2007-07-18 Products
PCT/GB2008/000518 WO2008099185A1 (en) 2007-02-15 2008-02-14 Human monoclonal antibodies to the thyrotropin receptor which act as antagonists

Publications (2)

Publication Number Publication Date
CN101657468A CN101657468A (zh) 2010-02-24
CN101657468B true CN101657468B (zh) 2014-09-03

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CN200880011577.5A Active CN101657468B (zh) 2007-02-15 2008-02-14 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体

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JP (1) JP5345556B2 (enExample)
CN (1) CN101657468B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5997446B2 (ja) * 2011-02-03 2016-09-28 アークレイ株式会社 甲状腺ホルモン固定化担体の液体試薬およびその用途
JP7025041B2 (ja) * 2019-12-26 2022-02-24 ヤマサ醤油株式会社 変異が導入された甲状腺刺激ホルモン受容体
CN112269026A (zh) * 2020-09-04 2021-01-26 首都医科大学附属北京朝阳医院 一种适用于tsh粉末状国际标准物质浓度准确配制的方法
AU2023335715A1 (en) * 2022-08-31 2025-03-20 Shanghai Scizeng Medical Technology Co., Ltd. Antibody binding to thyroid-stimulating hormone receptor and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9909661D0 (en) * 1998-06-06 1999-06-23 Rsr Ltd Assays for TSH receptor autoantibodies
DE19907094C1 (de) * 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
US7084257B2 (en) * 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US8110664B2 (en) * 2002-11-29 2012-02-07 Rsr Limited Binding partners for the thyrotropin receptor and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOHN L D.ET AL.characterization of monoclonal thyrotropin binding-inhibition autoantibodies from a hashimoto"s patient whose chindren ha inteauterine and neonatal throid disease..《THE JOURNAL OF CLINICAL EMDOCRINOLOGY AND METABOLISM》.1997,第82卷(第2期),3998-4009. *

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JP2010521139A (ja) 2010-06-24
JP5345556B2 (ja) 2013-11-20
CN101657468A (zh) 2010-02-24

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