CN101657232A - 牙膏组合物 - Google Patents
牙膏组合物 Download PDFInfo
- Publication number
- CN101657232A CN101657232A CN200880011287A CN200880011287A CN101657232A CN 101657232 A CN101657232 A CN 101657232A CN 200880011287 A CN200880011287 A CN 200880011287A CN 200880011287 A CN200880011287 A CN 200880011287A CN 101657232 A CN101657232 A CN 101657232A
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- China
- Prior art keywords
- polysaccharide
- described compositions
- aforementioned
- surfactant
- polysaccharides
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 239000000606 toothpaste Substances 0.000 title claims abstract description 13
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 13
- 150000004676 glycans Chemical class 0.000 claims abstract description 42
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 42
- 239000005017 polysaccharide Substances 0.000 claims abstract description 42
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000004094 surface-active agent Substances 0.000 claims abstract description 12
- 239000006260 foam Substances 0.000 claims abstract description 4
- 239000003921 oil Substances 0.000 claims description 23
- 238000006277 sulfonation reaction Methods 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000000551 dentifrice Substances 0.000 claims description 8
- 241001147468 Chondrus ocellatus Species 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 230000001680 brushing effect Effects 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 abstract 1
- 239000000679 carrageenan Substances 0.000 abstract 1
- 229940113118 carrageenan Drugs 0.000 abstract 1
- 235000010418 carrageenan Nutrition 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- -1 nonionic Chemical class 0.000 description 6
- 230000035910 sensory benefits Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- ZIYRDJLAJYTELF-UHFFFAOYSA-N 2-bromo-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1Br ZIYRDJLAJYTELF-UHFFFAOYSA-N 0.000 description 1
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241001044369 Amphion Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 229930185605 Bisphenol Natural products 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
- 241000940372 Eucheuma denticulatum Species 0.000 description 1
- 241001467355 Gigartina Species 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 241000016511 Kappaphycus cottonii Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- TXXIWPTXQBKYOE-UHFFFAOYSA-N OC(=O)CC(CC(O)=O)(OP(=O)=O)C(O)=O Chemical class OC(=O)CC(CC(O)=O)(OP(=O)=O)C(O)=O TXXIWPTXQBKYOE-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- 229960005363 aluminium oxide Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002690 anti-lithiasic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
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- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 125000004181 carboxyalkyl group Chemical group 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- AZSFNUJOCKMOGB-UHFFFAOYSA-K cyclotriphosphate(3-) Chemical compound [O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 AZSFNUJOCKMOGB-UHFFFAOYSA-K 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical compound OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 229940005740 hexametaphosphate Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
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- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
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- 235000010493 xanthan gum Nutrition 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
包含表面活性剂、研磨剂、湿润剂、甘油三酯油、羧化多糖以及硫酸化或磺化多糖的牙膏组合物，以及硫酸化或磺化多糖、特别是角叉菜聚糖的用途，以改善牙膏的使用中泡沫质量。
Description
本发明涉及牙膏组合物，其具有优越的使用中的感觉益处。
在本领域中存在许多已知的牙膏组合物。其中一些包含油，例如(such a)调味油(flavouring oils)或甘油三酯油。我们已发现，这样的组合物由于所述油的影响可能具有在使用中的感觉问题。具体地，我们已发现由存在于牙膏中的表面活性剂产生的泡沫的特性可能受到不良影响。
意外地，我们已发现通过将硫酸化或磺化多糖和羧化多糖引入至包含甘油三酯油的牙膏组合物中可以获得优越的感觉益处。使用中的感觉益处，特别是察觉到的产品的泡沫品质通过本发明显著地改良。
在本发明的第一个方面中，提供有牙膏组合物，其包含表面活性剂、研磨剂、湿润剂、甘油三酯油、羧化多糖以及硫酸化或磺化多糖。
在本发明的第二个方面中，提供有清洁牙齿的方法，该方法包括使用本发明的第一个方面所述的组合物来擦刷。
在本发明的第三个方面中，提供有硫酸化或磺化多糖、特别是角叉菜聚糖的用途，其用以改善还包含表面活性剂、研磨剂、湿润剂、甘油三酯油以及羧化多糖的牙膏的使用中泡沫质量。
本发明中使用的所述表面活性剂可以是阴离子、非离子、阳离子、两性离子或两性表面活性剂，或它们的混合物。优选所述表面活性剂是阴离子性，特别是碱金属烷基硫酸盐，且尤其是十二烷基硫酸钠(SLS)。
表面活性剂的总量一般为0.1-10％，特别为0.5-5％，且尤其为1-3％，以全部组合物的重量计。
本发明中使用的所述研磨剂一般为颗粒研磨材料，比如二氧化硅、氧化铝、碳酸钙、磷酸二钙、焦磷酸钙、羟磷灰石、三偏磷酸盐、不溶性六偏磷酸盐或它们的混合物。也可以使用聚集颗粒研磨材料。优选的研磨材料是白垩和二氧化硅，特别优选二氧化硅。
研磨剂的总量一般为3-60％，特别为5-40％，且尤其为6％-20％，以全部组合物的重量计。
本发明中使用的所述湿润剂一般为多元醇，特别为选自甘油、山梨糖醇、丙二醇、木糖醇、乳糖醇或它们的混合物的多元醇。尤其优选山梨糖醇，该材料也用作甜味剂(参看下文)。
湿润剂的总量一般为1-60％，特别为5-50％，且尤其为10％-30％，以全部组合物的重量计。
本发明中使用的所述甘油三酯油优选为向日葵油，所述油对牙齿提供重要的维生素F源。使用包含向日葵油的组合物，本发明所述的感觉益处已特别明显。多于一种甘油三酯油可存在于所述组合物中。
甘油三酯油的总量一般0.5％以上，特别1％以上，且尤其1.5％以上，以全部组合物的重量计。为了使与所述甘油三酯油相关的感觉益处不太难以克服，所述甘油三酯油的量一般低于10％，特别为低于7％，且尤其低于5％，以全部组合物的重量计。
本发明中使用的所述羧化多糖一般为纤维素衍生物，特别为羧基烷基纤维素，且尤其为羧甲基纤维素(CMC)，一般作为其钠盐使用(SCMC)。所述羧化多糖一般用来增稠牙膏，也有助于该牙膏的感觉性质。
羧化多糖的总量一般为0.2％以上，特别为0.5％以上，且尤其为0.8％以上，以全部组合物的重量计。该总量优选低于5％，更优选低于2％，最优选低于1％，以全部组合物的重量计。
本发明中使用的所述硫酸化多糖或磺化多糖一般为硫酸化多糖，特别为线性硫酸化多糖，且尤其为角叉菜聚糖。在三种主要的商业类的角叉菜聚糖(Kappa，来自Kappaphycus cottonii；Iota，来自Eucheumaspinosum；和Lambda，其共同来源是Gigartina)中，优选Kappa和Iota。所述硫酸化或磺化多糖一般用来增稠牙膏，并有利地有助于该牙膏的感觉性质。
硫酸化或磺化多糖的总量优选为0.1％以上，更优选为0.25％以上，且最优选为0.4％以上，以全部组合物的重量计。该总量优选低于3％，更优选低于1.5％，且最优选低于0.6％，以全部组合物的重量计。
羧化多糖的总量与硫酸化或磺化多糖的总量的重量比优选为1∶2至10∶1，更优选为1∶1至5∶1，最优选为3∶2至3∶1。
所述优选的、更优选的及最优选的硫酸化或磺化多糖的总量，和所述优选的、更优选的及最优选的羧化多糖与硫酸化或磺化多糖的比率被认为特别有利于递送本发明的感觉益处，尤其是在表面活性剂和油包含物更为典型的浓度下。
本发明所述的牙膏组合物可以包含进一步的成分。除了上述纤维素衍生物，也可以使用改变牙膏流变性质的其它材料。优选的该类型的额外成分为聚乙二醇和增稠二氧化硅，比如Tixosil
来自Rhodia。该类型的其它成分为黄原胶、阿拉伯树胶、合成聚丙烯酸酯和合成羧基乙烯基聚合物比如
除了上述甘油三酯油，也可以存在其它的油比如调味油。典型的调味油包括薄荷油和留兰香油。
维生素源，特别是维生素E源，比如乙酸维生素E是优选的进一步的成分。维生素E源特别优选于还包含向日葵油的组合物中，以使存在维生素E和维生素F源二者(参见上文)。
抗微生物剂是可以有利地使用于本发明的组合物中的进一步的成分。
实例包括三氯生、双氯苯双胍己烷、铜盐、锌盐和亚锡盐(比如柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸锌钠(sodium zinc citrate)、焦磷酸亚锡)、血根碱提取物、甲硝唑、季铵化合物(比如十六烷基氯化吡啶鎓)、双胍(比如双氯苯双胍己烷)、二葡萄糖酸盐、双辛氢啶、癸双辛胺啶、阿立西定以及卤化双酚化合物(比如2，2′-亚甲基双(4-氯-6-溴苯酚))。
防龋剂是可在本发明的组合物中有利地使用的进一步成分。这类试剂的实例包括氟化钠和氟化亚锡、氟化胺、单氟磷酸钠、三偏磷酸钠和酪蛋白。
也可以包括能够提高活性成分比如抗微生物剂的递送的聚合物。这类聚合物的实例是聚乙烯基甲基醚与马来酸酐的共聚物及其它类似的递送增强聚合物，例如记载于DE-A-3,942,643(Colgate)中的那些。
可被引入的其它成分包括：
菌斑缓冲剂比如尿素、乳酸钙、甘油磷酸钙和聚丙烯酸锶；
抗炎试剂，比如布洛芬、氟比洛芬、阿司匹林和吲哚美辛；
脱敏剂，比如柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾和锶盐；
抗结石剂，比如碱金属焦磷酸盐、含有次磷酸盐的聚合物，有机膦酸盐和磷酸柠檬酸盐(phosphocitrates)；
生物分子，比如细菌素、抗体和酶；
蛋白质材料，比如胶原；
防腐剂；
乳浊剂；
着色剂；
pH调节剂；
甜味剂，比如糖精和山梨糖醇(参见上文)；
漂白剂，比如过氧化合物(例如过氧二磷酸钾)；
缓冲所述组合物的pH和离子强度的缓冲剂和盐；和
可药用的载体，例如淀粉、蔗糖、水或水/醇系统。水是特别优选的可药用载体，且以组合物的总重量计，典型地以5-95％，特别为15-75％，尤其为35-60％存在于本发明的组合物中。
实施例。
在以下实施例中，比较实施例通过字母说明，而根据本发明的实施例则通过数字说明。所有成分的量表示为重量百分比。
通过本领域已知的标准方法制备了表1所示的牙膏组合物。除了将比较实施例A中0.5％的SCMC替代为实施例1中的角叉菜聚糖，组成相同。
表1
进行了表1所示组合物的性能估计试验以评价使用者对该产品的感受。雇用并要求21位受训的专门小组成员使用0-10的线性标度通过一系列属性对所述牙膏进行评价。对所述牙膏的使用中感受的平均结果示于表2。
表2
本发明所述的组合物被发现提供比比较实施例显著更高的泡沫质量感受。
Claims (11)
1.牙膏组合物，其包含表面活性剂、研磨剂、湿润剂、甘油三酯油、羧化多糖以及硫酸化或磺化多糖。
2.权利要求1所述的组合物，其中所述表面活性剂是阴离子表面活性剂。
3.权利要求1或2所述的组合物，其中所述表面活性剂是十二烷基硫酸钠。
4.前述权利要求中任一项所述的组合物，进一步包含调味油。
5.前述权利要求中任一项所述的组合物，其中所述甘油三酯油是向日葵油。
6.前述权利要求中任一项所述的组合物，其中所述羧化多糖为羧甲基纤维素。
7.前述权利要求中任一项所述的组合物，其中所述硫酸化多糖或磺化多糖为角叉菜聚糖。
8.前述权利要求中任一项所述的组合物，其中所述甘油三酯油存在的量为0.5％以上，所述羧化多糖存在的量为0.5％以上，所述硫酸化多糖或磺化多糖存在的量为0.25％以上，所有百分数均基于重量。
9.前述权利要求中任一项所述的组合物，其中所述羧化多糖的总量与硫酸化多糖或磺化多糖的总量的比为3∶2至3∶1。
10.清洁牙齿的方法，该方法包括使用权利要求1-9中任一项所述的组合物来擦刷。
11.硫酸化或磺化多糖、特别是角叉菜聚糖的用途，其用以改善还包含表面活性剂、研磨剂、湿润剂、甘油三酯油以及羧化多糖的牙膏的使用中泡沫质量。
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| EP07105493 | 2007-04-02 | ||
| EP07105493.6 | 2007-04-02 | ||
| PCT/EP2008/052445 WO2008119605A1 (en) | 2007-04-02 | 2008-02-28 | Toothpaste composition |
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| CN101657232A true CN101657232A (zh) | 2010-02-24 |
| CN101657232B CN101657232B (zh) | 2015-09-23 |
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| EP (1) | EP2139562B1 (zh) |
| CN (1) | CN101657232B (zh) |
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| CL (1) | CL2008000966A1 (zh) |
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| DE102011082431A1 (de) | 2011-09-09 | 2013-03-14 | Henkel Ag & Co. Kgaa | Spezialzahncreme für elektrische Zahnbürsten I |
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| GB2132996B (en) * | 1982-12-29 | 1986-12-10 | Lion Corp | Oral composition and abrasive therefor |
| US4565692A (en) * | 1983-12-23 | 1986-01-21 | Colgate-Palmolive Company | Extrudable dentifrice |
| JP2775915B2 (ja) * | 1989-11-06 | 1998-07-16 | ライオン株式会社 | 非イオン性界面活性剤 |
| ES2134743B1 (es) * | 1998-02-06 | 2000-05-01 | Biocosmetics Sl | Composicion para el tratamiento de la halitosis. |
| BR9815703A (pt) * | 1998-03-06 | 2000-11-14 | Fmc Corp | Composição de pasta de dente |
| AU4143999A (en) * | 1998-05-15 | 1999-12-06 | Unilever Plc | Oral composition comprising capsules |
| US8753675B1 (en) * | 2000-01-20 | 2014-06-17 | Raj K. Chopra | Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications |
| US6770264B2 (en) * | 2001-11-13 | 2004-08-03 | Noville, Inc. | Chewing gum compositions comprising diglycerol |
| WO2005089703A1 (ja) * | 2004-03-19 | 2005-09-29 | Kao Corporation | 歯磨用組成物 |
| JP2007045743A (ja) * | 2005-08-10 | 2007-02-22 | Lion Corp | 歯磨組成物 |
| US20080031831A1 (en) * | 2005-10-21 | 2008-02-07 | Technology & Marketing Consulting | Oral anti-calculus compositions and methods of use thereof |
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- 2008-02-28 CN CN200880011287.0A patent/CN101657232B/zh not_active Expired - Fee Related
- 2008-02-28 US US12/593,923 patent/US20100226865A1/en not_active Abandoned
- 2008-02-28 BR BRPI0808240-5A patent/BRPI0808240A2/pt not_active IP Right Cessation
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| EP2139562A1 (en) | 2010-01-06 |
| CL2008000966A1 (es) | 2009-01-16 |
| EP2139562B1 (en) | 2013-07-03 |
| CN101657232B (zh) | 2015-09-23 |
| WO2008119605A1 (en) | 2008-10-09 |
| BRPI0808240A2 (pt) | 2014-07-29 |
| US20100226865A1 (en) | 2010-09-09 |
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