CN101647962A - Traditional Chinese medicine preparation for curing depression - Google Patents
Traditional Chinese medicine preparation for curing depression Download PDFInfo
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- CN101647962A CN101647962A CN200910084289A CN200910084289A CN101647962A CN 101647962 A CN101647962 A CN 101647962A CN 200910084289 A CN200910084289 A CN 200910084289A CN 200910084289 A CN200910084289 A CN 200910084289A CN 101647962 A CN101647962 A CN 101647962A
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Abstract
The invention discloses a traditional Chinese medicine preparation for curing depression. The traditional Chinese medicine preparation is prepared from the following components by weight parts: lily 28-32, fried date kernel 18-22, dens draconis 10-14, tortoise plastron 10-14, dried tangerine peel 10-14, light wheat 28-32, platycladi seed 10-14 and fruit of Chinese magnoliavine 8-12. The traditional Chinese medicine preparation has remarkable curative effect, has no adverse reaction, leads to good patient compliance during the application and is good for curing, enhancing and maintaining the disease.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used for the treatment of depression, more precisely is the Chinese medicine preparation of treatment involutional depression.
Background technology
Depression is a kind of common frdquently encountered disease, and World Health Organization's statistics patients with depression accounts for the 3-5% of whole world population, is equivalent to 1.2-2 hundred million people.In western countries such as the U.S., Germany, 10% resident has depressed tendency.And in country and area underdeveloped, the population ratio that has the depression dominant character is higher, and some are local even reached 20%.Message from psychiatric department branch of Chinese doctors'associations shows: the present patients with depression of China has 3,000 ten thousand approximately.
Because of all burdens that depression brought make the whole world all can lose the output value of 2%-5% every year.According to World Health Organization's statistics, with regard to the disease burden, depression has become the fourth-largest disease in the world at present, and expecting the year two thousand twenty may will become the human second largest illness that is only second to cardiovascular disease.
78.2 years old mean age in life-span of China women, average age of meuopause 49.5 years old, involutional depression is a kind of chronic recurrent disease, account for climacteric crowd's 5.8%, account for 78% of climacteric syndrome, low with the emotion persistence is principal character, social function obviously reduces, the suicide risk height.Along with social development, its sickness rate rises year by year, has become typical case's representative of a biological psychological social medicine pattern.Drug therapy is based on Hormone Replacement Therapy, and because of its potential carcinogenecity, treatment interruption ratio is up to 41.0%.Therefore seeking the medicine of the treatment by Chinese herbs involutional depression with Chinese quintessence of Chinese culture, is the common hope of pursuing of doctor and patient.
Summary of the invention
At above-mentioned situation, the purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of involutional depression, involutional depression can be effectively treated, and side effect minimum can be dropped to.
To achieve these goals, the present invention adopts Bulbus Lilii, Semen Ziziphi Spinosae (parched), Dens Draconis, Carapax et Plastrum Testudinis, Pericarpium Citri Reticulatae, Fructus Tritici Levis, Semen Platycladi, Fructus Schisandrae Chinensis reasonable compatibility, be processed into the Chinese medicine preparation for the treatment of involutional depression through science, the weight portion proportioning is respectively: Bulbus Lilii 28-32 weight portion, Semen Ziziphi Spinosae (parched) 18-22 weight portion, Dens Draconis 10-14 weight portion, Carapax et Plastrum Testudinis 10-14 weight portion, Pericarpium Citri Reticulatae 10-14 weight portion, Fructus Tritici Levis 28-32 weight portion, Semen Platycladi 10-14 weight portion, Fructus Schisandrae Chinensis 8-12 weight portion.
Described Chinese medicine preparation is a said dosage form on any materia medica.
Described dosage form is a capsule, tablet, granule, oral liquid, pill, powder, sublimed preparation, any pharmaceutical dosage form in the unguentum.
Beneficial effect of the present invention is:
Curative effect of the present invention is affirmed, no obvious adverse reaction, and it is good that the patient uses compliance, is beneficial to treatment of diseases, consolidates and keeps.
The specific embodiment
Below in conjunction with embodiment and practical situation the present invention is elaborated.
The prescription requirement according to the present invention is in weight portion proportioning Bulbus Lilii 28 weight portions, Semen Ziziphi Spinosae (parched) 18 weight portions, Dens Draconis 10 weight portions, Carapax et Plastrum Testudinis 10 weight portions, Pericarpium Citri Reticulatae 10 weight portions, Fructus Tritici Levis 28 weight portions, Semen Platycladi 10 weight portions, Fructus Schisandrae Chinensis 8 weight portions are mixed and made into Chinese medicine preparation.
Bulbus Lilii, Carapax et Plastrum Testudinis, Dens Draconis nourishing YIN for suppressing the hyperactive YANG in above-mentioned prescription, Semen Ziziphi Spinosae (parched), Semen Platycladi, Fructus Schisandrae Chinensis, the Fructus Tritici Levis Qi-benefiting and heart-nourishing convergence motive of allaying excitement, the assistant Pericarpium Citri Reticulatae is regulated the flow of vital energy and is amusing.Above-mentioned science compatibility can reach the effect that nourishing YIN for suppressing the hyperactive YANG nourishes heart and allays excitement jointly, thereby makes involutional depression be able to effective treatment.
Below the effect of mouse experiment and clinical practice treatment depression has all been obtained fully proving.
The pharmacodynamics pharmacological toxicology is learned situation
According to bureau of drug administration of People's Republic of China (PRC) new drug research guideline, show that after deliberation changing Chinese medicine preparation has inhibitory action to nervus centralis, the appropriate sleeping number of subliminal hypnosis dosage of receiving of experiment mice penta crust is obviously increased, the sleep time-lag action is arranged.Show through animal acute toxicity test, be equivalent to 300 times of people's clinical application amount with this Chinese medicine preparation suspension to mouse stomach, mice does not have movable unusual, does not more see death, so as safe as a house during this Chinese medicine preparation oral administration.This Chinese medicine preparation long term toxicity test studies show that this Chinese medicine preparation does not have influence to the normal growth growth of rat, and the every index of hemogram checking is all in normal range, and this Chinese medicine preparation has no adverse effects to the hemopoietic function of rat, does not damage hepatic and renal function.The all no abnormal pathologic of main organs pathological examination changes, and illustrates that this Chinese medicine preparation is very safe.
In order further to estimate the clinical efficacy of this Chinese medicine preparation, 61 routine involutional depression patients are observed, and to establish HRT be matched group that the observation of system has been carried out in its curative effect, safety and side effect, and situation is as follows:
1, alternative
1.1 diagnostic criteria: meet the diagnostic criteria of " psychiatry " involutional depression; HAMD depression scale＞23 minute person carries out deciding degree.
Include standard in: 40～62 years old (1) age; (2) Hamilton depressive scale.(HAMD24 item rating)＞23 fens persons; (3) meet Chinese mental sickness diagnosis and the single outbreak of the middle affective disorder diagnostic criteria of classification (CCMD-II) and the depression or the depressed diagnostic criteria mutually of bipolar affective disorder of outbreak repeatedly.
1.2 climacteric women 61 examples.Be divided into Chinese medicine preparation group and HRT treatment group at random, Chinese medicine preparation group 38 examples, 40～60 years old age, average (49.67 ± 4.21) year, the course of disease (1.40 ± 0.88) year.HRT organizes 23 examples, 43～62 years old age, average (52.65 ± 5.34) year, the course of disease (1.68 ± 1.02) year.
2, method
2.1 medicine
The every Bao Yuechong 18G of Chinese medicine preparation; The medroxyprogestetone acetate sheet: every 2mg, Xianju, Zhejiang pharmaceutical factory produces.Premarin Tablet: every 0.625mg, U.S. Hui Shi one Ayerst drugmaker produces.
2.2 Therapeutic Method
The Chinese medicine preparation group, every day 2 times, was taken 3 months continuously by each 1 bag.HRT treatment group is taken Premarin Tablet, and each 0.625mg is oral every day 1 time, menstruation beginning in the 5th day, logotype 20 days; The each 4mg of medroxyprogestetone acetate sheet, oral every day 2 times, logotype 7 days is taken at Premarin Tablet and to be played clothes in 20 days, is 1 cycle altogether, observes 3 cycles altogether.
2.3 observation item
Treatment front and back HAMD scale is marked and is subtracted the branch rate, detect the content that two treatment groups are treated front and back blood plasma 5 one hydroxytryptamines (5-HT), norepinephrine (NE) concentration and serum estradiol (E2), follicule-stimulating hormone (FSH) (FSH), lutropin (LH) with enzyme linked immunosorbent assay, transvaginal sonography is surveyed endometrium thickness.
2.4 statistical method
Adopt the t check, multiple linear regression analysis etc.
3, result
3.1 curative effect determinate standard
Subtract the branch rate with the 12nd all HAMD depression scale scorings and judge, integrated value before efficacy determination value=(integrated value one treatment back integrated value before the treatment)/treatment, recovery from illness in the recent period is decision content=1; Produce effects is decision content＞2/3; Transfer decision content between 1/3～2/3 well; Invalid is decision content＜1/3.
3.2 the scoring of HAMD depression scale relatively before and after two groups of treatments
HAMD scale treatment back total points subtracts the branch rate and shows that this Chinese medicine preparation is (65.56 ± 24.35) %, and the HRT group is (38.32 ± 18.62) %.Comparing difference has significance (P＜0.01) between this Chinese medicine preparation total effective rate 88.31%, 68.42%, two group of HRT group total effective rate.This Chinese medicine preparation treatment back total points subtracts the branch rate and 5 factors all have obvious decline, with comparing difference before the treatment significance (P＜0.01) is arranged.The HRT group is relatively preceding with treatment, and anxiety, cognitive 2 differences have significance (P＜0.01); Body weight, sleep disorder difference have significance (P＜0.05).This Chinese medicine preparation of treatment back compares with the HRT group, and anxiety, cognition have notable difference (P＜0.01); Body weight, feeling of despair difference have significance (P＜0.05); Sleep disorder difference does not have significance (P＞0.05).See Table 1.
HAMD scale factor scores relatively before and after the table 1 liang group treatment
| Group | The example number | Time | Anxiety | Body weight | Cognitive | Sleep disorder | Feeling of despair |
| Chinese medicine preparation | ??38 | Before the treatment | ??9.32± ??1.45 | ??1.35± ??0.89 | ??9.32± ??2.74 | ??5.30± ??0.74 | ??6.20± ??2.32 |
| After the treatment | ??3.54± ??1.35 | ??0.00± ??0.00 | ??1.70± ??1.56 | ??2.42± ??0.76 | ??1.82± ??1.31 | ||
| ??HRT | ??23 | Before the treatment | ??9.55± ??1.90 | ??0.74± ??0.87 | ??8.83± ??3.37 | ??3.81± ??1.86 | ??5.82± ??2.23 |
| After the treatment | ??5.58± ??1.89 | ??0.16± ??0.37 | ??4.42± ??2.49 | ??2.96± ??1.52 | ??2.76± ??1.28 |
Annotate: relatively preceding with the treatment of this group, P＜0.05; P＜0.01; Compare P＜0.05, P＜0.01 with HRT group treatment back
Blood plasma 5-HT, NE, 5-HT/NE odds ratio are before and after 3 liang of group treatments
See Table 2.The blood plasma 5-HT concentration reduction of Chinese medicine preparation treatment back, NE concentration rises, and 5-HT/NE ratio descends, and the three all has significance (P＜0.01) with the preceding comparing difference of treatment.The HRT group treats back 5-HT concentration and NE concentration rises, and 5HT/NE ratio descends, but does not have significance (P＞0.05) with the preceding comparing difference of treatment.Treatment back Chinese medicine preparation between two groups " blood plasma 5-HT concentration and 5-HT/NE ratio is than HRT group low (P＜0.05); Two groups of comparing differences of NE concentration do not have significance (P＞0.05).
Monoamine neurotransmitter relatively before and after the table 2 liang group treatment
| Group | The example number | Time | ??5-HT(μg/L) | ??NE(μg/L) | ??5-HT/NE |
| Chinese medicine preparation | ??38 | Before the treatment | ??6.45±2.95 | ??5.89±3.08 | ??1.38±1.17 |
| After the treatment | ??4.06±1.45 | ??11.97± ??6.49 | ??0.43±0.28 | ||
| ??HRT | ??23 | Before the treatment | ??5.04±2.59 | ??7.63±5.42 | ??1.71±2.85 |
| After the treatment | ??6.16±3.65 | ??10.63± ??8.46 | ??1.01±1.03 |
Annotate: relatively preceding with the treatment of this group, P＜0.01; Compare P＜0.05 with HRT group treatment back
E2, FSH, LH, FSH/LH are relatively before and after 4 liang of group treatments
See Table 3.This Chinese medicine preparation treatment back E2 content raises (P＜0.01), and FSH, LH content descend (P＜0.05), FSH/LH value decline (P＜0.01 or P＜0.05).HRT group treatment back E2 raises (P＜0.01) FSH/LH value decline (P＜0.05).
Endocrine hormone relatively before and after the table 3 liang group treatment
| Group | Example | Time | ??E2(μ | ??FSH | ??LH | ??FSH/LH |
| Number | ??g/L) | |||||
| Chinese medicine preparation | ??38 | Before the treatment | ??18.48± ??23.42 | ??54.65± ??33.36 | ??29.87± ??18.65 | ??2.00± ??1.01 |
| After the treatment | ??41.56± ??29.21 | ??39.24± ??31.12 | ??22.69± ??12.76 | ??1.52± ??0.88 | ||
| ??HRT | ??23 | Before the treatment | ??20.89± ??25.04 | ??58.87± ??32.38 | ??21.98± ??12.90 | ??2.72± ??1.47 |
| After the treatment | ??50.46± ??34.35 | ??54.74± ??37.29 | ??29.46± ??27.76 | ??1.93± ??0.83 |
Annotate: relatively preceding with the treatment of this group, P＜0.05, P＜0.01
Endometrium thickness relatively before and after 5 liang of group treatments
Endometrium thickness is all in normal range before two groups of patient treatments, this Chinese medicine preparation (3.86 ± 1.76) mm, and HRT organizes (3.22 ± 1.65) mm; This Chinese medicine preparation treatment back endometrium thickness ((3.27 ± 1.43) mm] change not obviously, HRT group treatment back endometrium thick partially [(4.74 ± 1.48) mm] has significance (P＜0.05) with comparing difference before the treatment.
4, conclusion
4.1 Chinese medicine is thought: suffering from a deficiency of the kidney in the involutional depression is to belong to physiological phenomenon, and the heart-fire stagnation of liver-QI is the pathological manifestations of primary disease, its treatment, Chinese medicine is thought will make " YIN and YANG in a relative equilibrium; life activities being normally maintained " the internal organs negative and positive adapt to change of age and keep equilibrium between yin and yang, so to adjust the body negative and positive.
This Chinese medicine preparation cures mainly: hyperactivity of YANG due to deficiency of YIN, discordance between water(the kidney)and fire(the heart), disarmony between the heart and kidney.Fidgets due to deficiency cardiopalmus is insomnia or little sleep disturbed by dreams, the gallbladder layer of having a guilty conscience, forgetful dizziness, malaise, the thin thin few tongue of body of the tongue, stringy and thready pulse.
Bulbus Lilii, Carapax et Plastrum Testudinis, Dens Draconis nourishing YIN for suppressing the hyperactive YANG in this Chinese medicine preparation, Semen Ziziphi Spinosae (parched), Semen Platycladi, Fructus Schisandrae Chinensis, the Fructus Tritici Levis Qi-benefiting and heart-nourishing convergence motive of allaying excitement, the assistant Pericarpium Citri Reticulatae is regulated the flow of vital energy and is amusing.
4.2 influence to monoamine neurotransmitter
Research data shows that rat hypothalamus 5-HT content increased with the monthly age, and the hypothalamic changes of Catecholamine Content of senile rat then descends with the monthly age, therefore, the dysequilibrium of neurotransmitter in the senile rat brain, promptly 5-HT/DA or 5HT/NE ratio increase.This experiment Chinese medicine preparation can make the 5-HT content of rising reduce, and meets the variation of ovarian function decline and neurotransmitter in the zoopery.Therefore this Chinese medicine preparation promotes the function of noradrenergic neuron by suppressing the synthetic of 5-HT, regulates monoamine neurotransmitter, makes it reach poised state again.
4.3 improvement to endocrine dysfunction
The untoward reaction that causes breast carcinoma, carcinoma of endometrium and ovarian cancer at a specified future date can't be got rid of in the HRT therapy, and the patient uses poor compliance.Show that according to zoopery this Chinese medicine preparation can directly act on the ovary uterine cancer cell, also can act on hypophysis, hypothalamus or higher maincenter simultaneously, directly or indirectly regulate the short gonad function of hypophysis.Experimental result shows that this Chinese medicine preparation can fundamentally regulate gonad axis, and too many levels is regulated reproductive endocrine function, and does not have tangible untoward reaction.
4.4 influence to the scoring of HAMD scale
HAMD scale total points subtracts branch rate Chinese medicine preparation group and organizes apparently higher than HRT, compare before and after 5 factor in treatment, the treatment back scoring of Chinese medicine preparation group obviously reduces, and conforms to the improvement of patient's depressive symptom, relatively has clear improvement before 4 selected factors of especially reacting the involutional depression feature and the treatment.Show this Chinese medicine preparation group to improve somatization, alleviate depression emotion, establish the life confidence better curative effect is arranged.
4.5 untoward reaction
Chinese medicine preparation group treatment back does not have 1 routine abnormal uterine bleeding, no breast sense of discomfort; HRT group treatment back B ultrasonic is measured endometrium thickness and is obviously thickened, and with comparing difference before the treatment significance is arranged, and removes 2 exceptions, and metrorrhagia and distending pain of the breast sense of discomfort are all arranged.This Chinese medicine preparation curative effect is described certainly, no obvious adverse reaction, it is good that the patient uses compliance, is beneficial to treatment of diseases, consolidates and keeps.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of depression is characterized in that, it is by following weight portion
Chinese medicinal raw materials is made:
Bulbus Lilii 28-32 weight portion
Semen Ziziphi Spinosae (parched) 18-22 weight portion
Dens Draconis 10-14 weight portion
Carapax et Plastrum Testudinis 10-14 weight portion
Pericarpium Citri Reticulatae 10-14 weight portion
Fructus Tritici Levis 28-32 weight portion
Semen Platycladi 10-14 weight portion
Fructus Schisandrae Chinensis 8-12 weight portion.
2, Chinese medicine preparation according to claim 1 is characterized in that: described Chinese medicine preparation is a said dosage form on any materia medica.
3, Chinese medicine preparation according to claim 2 is characterized in that: described dosage form is a capsule, tablet, granule, oral liquid, pill, powder, sublimed preparation, any pharmaceutical dosage form in the unguentum.
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| CN200910084289A CN101647962A (en) | 2009-05-20 | 2009-05-20 | Traditional Chinese medicine preparation for curing depression |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225186A (en) * | 2011-06-27 | 2011-10-26 | 史建钢 | Medicine for treating neurosis and preparation method thereof |
| CN102764407A (en) * | 2011-05-03 | 2012-11-07 | 郭丽 | Traditional Chinese medicinal decoction for treating depression |
| CN105288282A (en) * | 2015-11-04 | 2016-02-03 | 闫超 | Preparation with effects of nourishing heart and soothing nerves for patients suffering from depression and preparation method thereof |
| CN112656848A (en) * | 2021-01-07 | 2021-04-16 | 阿鲁科尔沁同济医院 | Traditional Chinese medicine composition for resolving stagnation and relieving spasm and preparation method thereof |
-
2009
- 2009-05-20 CN CN200910084289A patent/CN101647962A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764407A (en) * | 2011-05-03 | 2012-11-07 | 郭丽 | Traditional Chinese medicinal decoction for treating depression |
| CN102764407B (en) * | 2011-05-03 | 2014-03-19 | 密继清 | Traditional Chinese medicinal decoction for treating depression |
| CN102225186A (en) * | 2011-06-27 | 2011-10-26 | 史建钢 | Medicine for treating neurosis and preparation method thereof |
| CN105288282A (en) * | 2015-11-04 | 2016-02-03 | 闫超 | Preparation with effects of nourishing heart and soothing nerves for patients suffering from depression and preparation method thereof |
| CN112656848A (en) * | 2021-01-07 | 2021-04-16 | 阿鲁科尔沁同济医院 | Traditional Chinese medicine composition for resolving stagnation and relieving spasm and preparation method thereof |
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Application publication date: 20100217 |