CN101637411A - Tiny vein injection drug delivery system on body surface of experimental animal - Google Patents
Tiny vein injection drug delivery system on body surface of experimental animal Download PDFInfo
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- CN101637411A CN101637411A CN200910013191A CN200910013191A CN101637411A CN 101637411 A CN101637411 A CN 101637411A CN 200910013191 A CN200910013191 A CN 200910013191A CN 200910013191 A CN200910013191 A CN 200910013191A CN 101637411 A CN101637411 A CN 101637411A
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Abstract
The invention relates to a drug delivery system for experimental animals, in particular to a tiny vein injection drug delivery system on body surfaces of experimental animals. The system comprises a fixed chamber 5 for experimental animals, a simple desk type magnifying glass, a vascular clamp 7 and an injector 1 with a superfine injection needle 2, wherein the fixed chamber 5 for experimental animals fixes experimental animals; the vascular clamp 7 is clamped above injection blood vessel; the injector 1 is connected with the superfine injection needle 2; the simple desk type magnifying glassis arranged above vein injection operation, and the injection can be carried out; and component parts of the device can be used solely or be in arbitrarily combined use according to actual operation requirement. The invention has the beneficial effect that the tiny vein injection process of experimental animals is more accurate, efficient, convenient and fast.
Description
Affiliated technical field
Patent of the present invention relates to a kind of laboratory animal doser, especially a kind of tiny vein injection drug delivery system on body surface of experimental animal that is used for.
Background technology
The small intravenously administrable of body surface is the laboratory animal medication of using always, but because its technical difficulty is higher, success rate is very low in the practical operation, especially in the long term administration process, often can't finish because of the administration operation failure causes whole experiment.
The small intravenously administrable method of laboratory animal adopts manual operations more at present, and traditional operating process is the beaker that mice is placed back-off, and mouse tail is exposed to outside the beaker, with 1 milliliter of syringe caudal vein is carried out drug administration by injection.When adopting this method to operate, experiment mice can not finely be fixed, and laboratory animal is in the struggle state all the time, often cause can't inserting needle or inserting needle after because animal struggle needle pierces blood vessel causes the failure of an experiment.In addition, when adopting this kind method to carry out tail vein injection, be difficult for owing to the mouse tail vein blood vessel is more tiny full when causing injecting behind the inaccurate or inserting needle of inserting needle resistance bigger, cause local swelling to bleach and make the injection failure, accuracy rate is lower.
Hand-type when patent CN:200810018231 utilizes special pull bar folder that the operator is carried out mouse tail vein injection is fixed up, the inserting needle position is all consistent with this hand-type with the inserting needle depth during per injection later on, but because the mice individual variation is bigger, tail length, thickness are inhomogeneous, use same depth of needle and needle angle, the actual needs that can't be fit to all test mices so this patent effect in practical operation is undesirable, is used limited.
At present the employed syringe needle of report is all thicker, is difficult to penetrate the small vein of laboratory animal, even if or penetrate small vein, but, cause the injection failure because syringe needle is crossed and slightly punctured blood vessel wall easily and cause medicine liquid leakage.
Summary of the invention
For overcoming the deficiency that exists in the above-mentioned laboratory animal tiny vein injection drug delivery.Patent of the present invention provides a kind of tiny vein injection drug delivery system on body surface of experimental animal, and this device can be simplified the operating process of laboratory animal body surface tiny vein injection, and can make this operating process more accurate, convenient, efficient.
In order to achieve the above object, the technical scheme of patent of the present invention is as follows:
Tiny vein injection drug delivery system on body surface of experimental animal is made of laboratory animal fixed bin 5, simple and easy desk-top magnifier, vascular clamp 7 and the syringe 1 that has a ultra-fine injection needle 2, laboratory animal fixed bin 5 is fixed laboratory animal, vascular clamp 7 is sandwiched in injection blood vessel top, syringe 1 links to each other with ultra-fine injection needle 2, simple and easy desk-top magnifier places intravenous injection operation top, just can inject, also can be according to the practical operation needs, independent or combination in any is used the building block of this device.
1. laboratory animal fixed bin:
For overcoming in the operating process, laboratory animal (rat, mice) can not finely be fixed, causing can't inserting needle, or laboratory animal is struggled behind the inserting needle, cause the injection failure, but laboratory animal fixed bin 5 of the present invention is the drum ladles that have extracting dividing plate 4 and laboratory animal fixed bin lid 9, but the slot that extracting dividing plate 4 is arranged on the laboratory animal fixed bin 5, according to the laboratory animal actual size, but select different slot positions to insert extracting dividing plate 4, laboratory animal can be fixed in the minimum space, effectively reduce laboratory animal struggle amplitude.For convenience of the caudal vein injection operation, covering 9 central authorities at the laboratory animal fixed bin is provided with the laboratory animal tail and passes hole 6, the laboratory animal tail is passed from the hole, like this because the Mus tail is subjected to the restriction of fixed bin spiral cover central aperture, can not change the position along with the animal limb twisting, easy operating carries out smoothly.
2. simple and easy desk-top magnifier:
Because the small venous volume of laboratory animal is little and very thin, when naked eyes carried out tiny vein injection, operator were difficult to determine the small venous position and the depth, judge whether syringe needle is also comparatively difficult in blood vessel.It is simple and easy desk-top magnifier more than 40 times that the present invention has designed amplification, simple and easy desk-top magnifier is made up of magnifier 3 and magnifying glass bracket 8, magnifying glass bracket 8 supports magnifier 3 and places intravenous injection operation top, magnifier 3 is liftable on magnifying glass bracket 8, can regulate the height of magnifier 3 according to practical situation, carry out tiny vein injection for 3 times at magnifier and not only can accurately locate small venous locations, and whether can accurately judge syringe needle at small intravenous, length, the depth of convenient control inserting needle and push away medicine opportunity.
3. vascular clamp:
Traditional method is normal before injection to adopt hot bath, smear method such as ethanol makes the small venous engorgement of laboratory animal, convenient injection, but the operating process of hot bath method is comparatively loaded down with trivial details, smears alcoholic acid method to make the operating position become sliding, strengthens operation easier.The present invention has designed the vascular clamp 7 of the crocodile mouth shape that makes things convenient for gripping, clamps injection blood vessel top with vascular clamp 7 during operation, makes the full rapidly chap of the small vein of laboratory animal, convenient injection.
4. the syringe that has ultra-fine injection needle:
Pluckings for overcoming syringe needle, the shortcoming of wearing out blood vessel easily after being difficult to enter small vein or entering small vein, the present invention selects that to have diameter be that the syringe 1 of 0.2 millimeter ultra-fine injection needle 2 carries out tiny vein injection for use, has effectively avoided because the operation failure that injection needle excessively slightly causes.
The invention has the beneficial effects as follows: make laboratory animal tiny vein injection process more accurate, efficient, easy, quick.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Fig. 2 is the syringe construction sketch map that has ultra-fine syringe needle.
Fig. 3 is simple and easy desk-top magnifying glass sketch map.
Fig. 4 is a laboratory animal fixed bin structural representation.
Among the figure: 1. syringe, 2. ultra-fine injection needle, 3. magnifier, but 4. extracting dividing plate, 5. laboratory animal fixed bin, 6. the laboratory animal tail passes the hole, 7. vascular clamp, 8. magnifying glass bracket, 9. laboratory animal fixed bin lid.
The specific embodiment
The mouse tail vein injection administration:
As shown in Figure 1, tiny vein injection drug delivery system on body surface of experimental animal is made of laboratory animal fixed bin 5, simple and easy desk-top magnifier, vascular clamp 7 and the syringe 1 that has a ultra-fine injection needle 2, but laboratory animal fixed bin 5 is for having the drum ladle of extracting dividing plate 4 and laboratory animal fixed bin lid 9, but the slot that extracting dividing plate 4 is arranged on the laboratory animal fixed bin 5 covers 9 central authorities at the laboratory animal fixed bin and the laboratory animal tail is set passes hole 6; Simple and easy desk-top magnifier is made up of magnifier 3 and magnifying glass bracket 8, and the amplification of magnifier 3 is more than 40 times, and magnifying glass bracket 8 supports magnifier 3 and places intravenous injection operation top; Vascular clamp 7 is the crocodile mouth shape, clamps injection blood vessel top with vascular clamp 7 during operation; It is 0.2 millimeter ultra-fine injection needle 2 that syringe 1 has diameter.
When carrying out mouse tail vein injection, carried mousetail earlier, mousetail is passed the laboratory animal tail that the laboratory animal fixed bin covers 9 central authorities pass hole 6, then mice is placed laboratory animal fixed bin 5 inlets, mice can crawl toward in the fixed bin by the light of nature, after treating that the mice metapedes enters laboratory animal fixed bin 5, screw laboratory animal fixed bin lid 9, according to mice size (young Mus, become Mus), but choose correct position and insert extracting dividing plate 4, laboratory animal is fixed in the small space of laboratory animal fixed bin 5, mousetail can be exposed to laboratory animal fixed bin 5 outsides like this, and the Mus tail can not move handled easily along with the twisting of mice limbs.After mice fixed, clamp the mouse tail root with vascular clamp 7, make the tail venous engorgement, operator's one hand-held syringe that ultra-fine syringe needle is housed, pinched mousetail on the other hand, in the magnifier of simple and easy desk-top magnifier 3 times accurately mouse tail vein position, location, the depths, be that the syringe 1 of 0.2 millimeter ultra-fine injection needle 2 carries out tiny vein injection and carries out tail vein injection again with having diameter then.Adopt the present invention and traditional method to carry out the mouse tail vein injection effect and relatively see Table 1.
Table 1 adopts traditional method and the present invention to carry out the mouse tail vein injection effect relatively
| Mice (only) | Success (only) | Failure (only) | Success rate | |
| Traditional method | ??20 | ??6 | ??14 | ??30％ |
| The present invention | ??20 | ??19 | ??1 | ??95％ # |
As can be seen from Table 1, statistical result showed the present invention can obviously improve the success rate of mouse tail vein injection, has statistical significance with the traditional method comparing difference, P＜0.05.
The rat tail vein drug administration by injection:
Specific embodiments is with embodiment 1, just laboratory animal fixed bin 5 and the laboratory animal fixed bins lid 9 that changes laboratory animal fixed bin 5 and the laboratory animal fixed bin lid 9 of mice into rat.
Mice foot plantar subcutaneous injection:
Expose the mice vola, under magnifier, choose sufficient sole of the foot vein, clamp mice foot sole of the foot vein proximal part with vascular clamp 7, at the accurate location mice foot sole of the foot veins of the magnifier of simple and easy desk-top magnifier 3 times, be that 1 pair of mice foot of syringe sole of the foot vein of 0.2 millimeter ultra-fine injection needle 2 is injected with having diameter then.
Rat sublingual vein drug administration by injection:
Behind the etherization rat, strut the rat oral cavity, expose sublingual vein, accurately locate the rat sublingual vein 3 times, inject with the 1 pair of rat sublingual vein of syringe that is connected with ultra-fine syringe needle 2 at the magnifier of simple and easy desk-top magnifier.
Claims (2)
1, tiny vein injection drug delivery system on body surface of experimental animal, it is characterized in that, this device is made of laboratory animal fixed bin (5), simple and easy desk-top magnifier, vascular clamp (7) and the syringe (1) that has ultra-fine injection needle (2), laboratory animal fixed bin (5) but for having the drum ladle that extracting dividing plate (4) and laboratory animal fixed bin cover (9), laboratory animal fixed bin (5) but on the slot of extracting dividing plate (4) is arranged, in laboratory animal fixed bin lid (9) central authorities the laboratory animal tail is set and passes hole (6); Simple and easy desk-top magnifier is made up of magnifier (3) and magnifying glass bracket (8), and the amplification of magnifier (3) is more than 40 times, and magnifier 3 is liftable on magnifying glass bracket 8, and magnifying glass bracket (8) supports magnifier (3) and places intravenous injection operation top; Vascular clamp (7) is the crocodile mouth shape, clamps injection blood vessel top with vascular clamp (7) during operation; It is 0.2 millimeter ultra-fine injection needle (2) that syringe (1) has diameter.
2, tiny vein injection drug delivery system on body surface of experimental animal according to claim 1, it is characterized in that, described laboratory animal fixed bin (5), simple and easy desk-top magnifier, vascular clamp (7) and have the syringe (1) of ultra-fine injection needle (2) can be separately or combination in any use.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910013191A CN101637411A (en) | 2009-08-12 | 2009-08-12 | Tiny vein injection drug delivery system on body surface of experimental animal |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910013191A CN101637411A (en) | 2009-08-12 | 2009-08-12 | Tiny vein injection drug delivery system on body surface of experimental animal |
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| CN101637411A true CN101637411A (en) | 2010-02-03 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897577A (en) * | 2010-08-25 | 2010-12-01 | 北京伊籁麦吉科技有限公司 | Animal fixing device having vein transillumination function |
| CN103479447A (en) * | 2013-09-30 | 2014-01-01 | 中国科学院深圳先进技术研究院 | Anesthesia auxiliary device |
| CN103610515A (en) * | 2013-12-09 | 2014-03-05 | 天津商业大学 | Fixing device for mouse caudal intravenous injection |
| CN103654994A (en) * | 2013-12-20 | 2014-03-26 | 苏州大学 | Mouse tail intravenous injection and blood sampling device |
| CN104546211A (en) * | 2013-10-29 | 2015-04-29 | 南京中医药大学 | Miniature administration and blood sampling system of jugular vein of rat |
| CN106037988A (en) * | 2016-07-05 | 2016-10-26 | 大连大学 | Multifunctional liquid-spraying dosing combination device for part of laboratory animal |
| CN108814764A (en) * | 2018-05-28 | 2018-11-16 | 孙姮 | A kind of device and its application method of experimental animal retention enema |
-
2009
- 2009-08-12 CN CN200910013191A patent/CN101637411A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897577A (en) * | 2010-08-25 | 2010-12-01 | 北京伊籁麦吉科技有限公司 | Animal fixing device having vein transillumination function |
| CN103479447A (en) * | 2013-09-30 | 2014-01-01 | 中国科学院深圳先进技术研究院 | Anesthesia auxiliary device |
| CN103479447B (en) * | 2013-09-30 | 2015-12-02 | 中国科学院深圳先进技术研究院 | Anesthesia auxiliary device |
| CN104546211A (en) * | 2013-10-29 | 2015-04-29 | 南京中医药大学 | Miniature administration and blood sampling system of jugular vein of rat |
| CN103610515A (en) * | 2013-12-09 | 2014-03-05 | 天津商业大学 | Fixing device for mouse caudal intravenous injection |
| CN103654994A (en) * | 2013-12-20 | 2014-03-26 | 苏州大学 | Mouse tail intravenous injection and blood sampling device |
| CN106037988A (en) * | 2016-07-05 | 2016-10-26 | 大连大学 | Multifunctional liquid-spraying dosing combination device for part of laboratory animal |
| CN106037988B (en) * | 2016-07-05 | 2018-01-05 | 大连大学 | A kind of multifunctional liquid-spraying administration combination unit local for experimental animal |
| CN108814764A (en) * | 2018-05-28 | 2018-11-16 | 孙姮 | A kind of device and its application method of experimental animal retention enema |
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