CN101632748B - Medicament for treating night crying of infants and preparation method thereof - Google Patents

Abstract

The invention provides a medicament for treating night crying of infants and a preparation method thereof. The medicament is prepared from snakegourd fruit, pangolin scales, Japanese honeysuckle stem, frankincense and the like, and can promote smooth circulation of vital energy and blood. Clinical experiments prove that the medicament can effectively treat the night crying of infants.

Description

A kind of unguentum for the treatment of the nocturnal fretfulness in infants and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of the nocturnal fretfulness in infants and preparation method thereof, belong to field of Chinese herbal.

Background technology

Night cry is meant children's, and things are as usual daytime, the uneasiness of then crying at nightfall, and perhaps children's regularly crys the disease of very then keeping crying all through the night every night.

The reason that causes the nocturnal fretfulness in infants is a lot, as fever, frightened, parasitosis, aphtha, hunger and diaper humidity or the like.Wherein some is a kind of normal reaction of children's, and some then is a morbid state.For because of the hunger or the moisture-induced nocturnal fretfulness in infants of diaper, should in time find, and behind sucking and changing babies' napkin, night cry can stop.Also have some children's to have to light a lamp night the custom of sleep, it is more than just to cry after turning off the light, and turning on light again and then crying from ending.Be because the head of a family is everlasting and works at night, can not be slept in children's's branch room again.Children's's bad habit of Chan Shenging unintentionally.Should progressively indoor light be dimmed, allow child come to terms with the variation of light, turn off electric light at last.

For the night cry that due to illness causes, dispel the cause of disease and then cry from ending, the traditional Chinese medical science is thought that the cause of disease that causes night cry is cold nothing more than, hot, is shied three aspects.

The ancient Chinese medicine doctor method of treatment is a lot of, and Golden Mirror of Medicine is divided into heat in the heart, spleen-cold syndrome with it and does not have in the cold no hotlist three kinds on type.But raising along with people's living standard, nowadays mostly be the only child in addition, father and mother have its treatment and add, so the present nocturnal fretfulness in infants is the most common with stagnation of QI due to dyspepsia, heat in the heart, no matter and equal the resembling with in various degree incoordination between the spleen and stomach, abdominal part flatulence of which kind of type.

Summary of the invention

Children's's internal organs are tender and lovely, and shape gas is sound as yet, is the main cause of night cry disease, and infant suffered from other diseases more before sending out night cry disease, especially are more common in after the digestive system and respiratory system disease.Children's's " vim and vigour are not filled ... the intestines and stomach is thin and brittle, spirit timid and weak-willed ", " the spleen tending to insufficiency usually ", wilful in addition voracity can not be from joints, or incoordination between cold and warm, the diseases caused by exogenous pathogenic factor internal injury all because of, all can influence transporting and transforming function of the spleen and stomach, so all diseases of the normal easily generation abdominal distention stagnation of QI.So with the Chinese juniper beach wormwood is monarch, heat clearing away promoting the circulation of QI the chest stuffiness relieving, loosening bowel to relieve constipation; Radix Et Rhizoma Rhei purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, Caulis Lonicerae heat-clearing and toxic substances removing, dispelling wind collateral dredging are minister; Olibanum, the shared promoting blood circulation and stopping pain of Myrrha borrow the power of walking to scurry of Squama Manis and Fructus Capsici that the efficacy of a drug is reached in the body thoroughly, and all medicines share, and nocturnal fretfulness in infants disease is won unusual merits repeatedly.

The invention provides a kind of medicine for the treatment of the nocturnal fretfulness in infants, this medicine is made by following bulk drugs:

Fructus Trichosanthis 10-30, Squama Manis 10-30, Caulis Lonicerae 10-30, Olibanum 10-30, Myrrha 10-30, Herba Patriniae 10-30, Radix Et Rhizoma Rhei 10-30, Fructus Capsici 20-40.

The crude drug part by weight of medicine of the present invention is preferably:

Fructus Trichosanthis 10, Squama Manis 30, Caulis Lonicerae 10, Olibanum 30, Myrrha 10, Herba Patriniae 30, Radix Et Rhizoma Rhei 10, Fructus Capsici 40.

Perhaps:

Fructus Trichosanthis 30, Squama Manis 10, Caulis Lonicerae 30, Olibanum 10, Myrrha 30, Herba Patriniae 10, Radix Et Rhizoma Rhei 30, Fructus Capsici 20.

Perhaps:

Fructus Trichosanthis 20, Squama Manis 20, Caulis Lonicerae 20, Olibanum 20, Myrrha 20, Herba Patriniae 20, Radix Et Rhizoma Rhei 20, Fructus Capsici 30.

Perhaps:

Fructus Trichosanthis 15, Squama Manis 15, Caulis Lonicerae 15, Olibanum 15, Myrrha 15, Herba Patriniae 15, Radix Et Rhizoma Rhei 15, Fructus Capsici 20.

Perhaps:

Fructus Trichosanthis 22, Squama Manis 18, Caulis Lonicerae 20, Olibanum 26, Myrrha 17, Herba Patriniae 19, Radix Et Rhizoma Rhei 20, Fructus Capsici 32.

Preferably, Olibanum is an Olibanum (processed) in the described crude drug, and Myrrha is a Myrrha (processed), and Squama Manis is stir-baked SQUAMA MANITIS or vinegar Squama Manis.。

Medicament form of pharmaceutical preparation of the present invention is a unguentum, mixture, capsule, tablet, granule, powder or pill, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, the acetic acid chloroethene is fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.

The preparation method of pharmaceutical composition unguentum of the present invention may further comprise the steps:

1) takes by weighing Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Olibanum, Myrrha, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici in proportion, clean, pulverize;

2) with Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici, add in the Oleum Sesami, heating, the literary composition back is military earlier for firepower, treat that medical material becomes black after, pull medical material out;

3) continue with the oil heating, to thickness;

4) add solvent and the substrate pharmaceutically accepted, continue heating, provoke splashing into to become in the cold water pearl and get final product to ointment with Glass rod;

5) the ointment medicine of step 4) gained is poured in the cold water while hot, attention is not arrived agglomerating, is dispersed into strip as far as possible; Soak 2-3 days in cold water after, cold water inclines;

6) Olibanum, Myrrha are ground into fine powder, and be standby;

7) with the ointment heating and melting of step 5) gained, add the fine powder of step 6) gained, stir, be uniformly coated on thick cloth or the paper, promptly.

For pediatric pharmaceuticals, interior application treatment has certain limitation, and applying Chinese medicine to the umbilicus therapy no pain, infant are easy to accept, applying Chinese medicine to the umbilicus and treatment by oral administration of medicines therapy principle are basic identical, be the methods difference, but the principle of its disease preventing and treating is the same, reaches the same goal by different routes in fact.SHENQUE acupoint is positioned at conception vessel, and conception vessel belongs to sea of yin channels (referring to Ren Channel), and with governor vessel the exterior and the interior mutually, hundred arteries and veins of all warps of common department's pipe human body are so umbilicus and Zhu Jing hundred pulse-phases are logical; Umbilicus again for dash, the institute of conception vessel circulation, and conception vessel, governor vessel, chong channel be " source three forks ", so three pulse classic gas phases are led to.Therefore applying Chinese medicine to the umbilicus spreads on skin with medicine, can reach in the natural fibre line of meat among, medicine sees through skin, through passages through which vital energy circulates is taken in the body, is melted among the body fluid, unites two into one with it, has inside and outside consistent wonderful.

The consumption of Chinese medicine composition of the present invention by the crude drug gross weight, is 90-250 gram/day, but sticks 1 dose every day.

The specific embodiment

Following embodiment is used to illustrate the preparation of medicine of the present invention, but it can not constitute any restriction to scope of the present invention.

Embodiment 1

The preparation of unguentum

Prescription:

Fructus Trichosanthis 20g, Squama Manis 20g, Caulis Lonicerae 20g, Olibanum 20g, Myrrha 20g, Herba Patriniae 20g, Radix Et Rhizoma Rhei 20g, Fructus Capsici 30g.

Preparation method:

1) takes by weighing Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Olibanum, Myrrha, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici by recipe quantity, clean, pulverize;

2) with Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici, add in the 500g Oleum Sesami, heating, the literary composition back is military earlier for firepower, treat that medical material becomes black after, pull medical material out;

3) continue with the oil heating, to thickness;

4) add Plumbum preparatium 20g, continue heating, provoke splashing into to become in the cold water pearl and get final product to ointment with Glass rod;

5) step 4) gained plaster is poured in the cold water while hot, attention is not arrived agglomerating, is dispersed into strip as far as possible; Soak 2 days in cold water after, cold water inclines;

6) Olibanum, Myrrha are ground into fine powder, and be standby;

7) with step 5) the ointment heating and melting, add the fine powder of step 6) gained, stir, be uniformly coated on thick cloth or the paper, promptly.

Embodiment 2

The preparation of mixture

Prescription:

Fructus Trichosanthis 10g, Squama Manis 30g, Caulis Lonicerae 10g, Olibanum 30g, Myrrha 10g, Herba Patriniae 30g, Radix Et Rhizoma Rhei 10g, Fructus Capsici 40g.

Preparation method:

1) takes by weighing Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Olibanum, Myrrha, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici by recipe quantity, clean, pulverize;

2) make mixture according to a conventional method promptly.

Embodiment 3

The preparation of unguentum

Prescription:

Fructus Trichosanthis 22g, Squama Manis 18g, Caulis Lonicerae 20g, Olibanum 26g, Myrrha 17g, Herba Patriniae 19g, Radix Et Rhizoma Rhei 20g, Fructus Capsici 32g.

Preparation method:

1) takes by weighing Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Olibanum, Myrrha, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici by recipe quantity, clean, pulverize;

2) with Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici, add in the 1000g Oleum Sesami, heating, the literary composition back is military earlier for firepower, treat that medical material becomes black after, pull medical material out;

3) continue with the oil heating, to thickness;

4) add Plumbum preparatium 38g, continue heating, provoke splashing into to become in the cold water pearl and get final product to ointment with Glass rod;

5) step 4) gained plaster is poured in the cold water while hot, attention is not arrived agglomerating, is dispersed into strip as far as possible; Soak 2 days in cold water after, cold water inclines;

6) Olibanum, Myrrha are ground into fine powder, and be standby;

7) with step 5) the ointment heating and melting, add the fine powder of step 6) gained, stir, be uniformly coated on thick cloth or the paper, promptly.

Embodiment 4:

The preparation of tablet

Prescription:

Fructus Trichosanthis 30g, Squama Manis 10g, Caulis Lonicerae 30g, Olibanum 10g, Myrrha 30g, Herba Patriniae 10g, Radix Et Rhizoma Rhei 30g, Fructus Capsici 20g.

Preparation method:

Preparation method is made tablet routinely.

Embodiment 5

The preparation of capsule

Prescription:

Fructus Trichosanthis 15g, Squama Manis 15g, Caulis Lonicerae 15g, Olibanum 15g, Myrrha 15g, Herba Patriniae 15g, Radix Et Rhizoma Rhei 15g, Fructus Capsici 20g.

Preparation method:

Preparation method is made capsule routinely.

Experimental example

For illustrating the activity of the traditional Chinese medicine composition for treating nocturnal fretfulness in infants of the present invention, use unguentum (to call medicine of the present invention in the following text) to carry out following clinical trial according to embodiment 1 preparation.

1 clinical data

1.1 physical data

400 examples all are the outpatient, are divided into treatment group and matched group at random.200 examples are organized in treatment: wherein male 118 examples, women 82 examples; The age 0-3 months 35 example, April-July 126 example, August-December 33 examples, other: 6 examples; Course of disease 6-15 days 136 examples, 16 days-January 38 example, January-February 26 example.Companion's shallow complexion 102 examples, poor appetite 23 examples, night sweat 133 examples, fright at night 91 examples, diarrhoea, abdominal distention 82 examples.

Matched group 200 examples: wherein male 98 examples, women 102 examples; The age 0-3 months 18 example, April-July 35 example, August-December 141 examples, other: 6 examples; Course of disease 6-15 days 129 examples, 16 days-January 33 example, January-February 38 example.Companion's shallow complexion, poor appetite person 153 examples, night sweat 34 examples, fright at night 26 examples, 17 examples of suffering from diarrhoea.Basic condition there was no significant differences such as two groups of patients' age, sex, the course of disease have comparability.

2. method

2.1 Therapeutic Method:

The treatment group umbilicus invention medicine that loses money in a business, every day potion.Matched group: calcium gluconate day is obeyed liquid, and 2/day, 1/day of vitamin A And D drops, day clothes.Two groups of cases were 1 course of treatment with 1 week all, judged curative effect continuous 2 courses of treatment.

2.2 criterion of therapeutical effect: recovery from illness: sleep is normal, and food is received increases, and complexion is more preceding ruddy, and stool normally; Take a turn for the better: sleep improves, and crying and screaming night alleviates, and food is received increase; Invalid: night cry is not seen and is clearly better or increases the weight of inappetence.

2.3 statistical analysis adopts the SPSS13 statistical analysis software to analyze, enumeration data adopts x ²Analyze, with P＜0.05 standard of significant difference the most.

3 results

3.1 efficacy result

Treatment group curative effect comparative result sees Table 1, and by table as seen, it is 99.5% that clinical total effective rate is organized in treatment, is significantly higher than matched group.

Table 1 liang group clinical efficacy comparative result n (%)

^*Compare P＜0.05 with matched group

3.2 a situation arises in untoward reaction

Treatment group matched group is not all found obvious adverse reaction.

4 conclusions

Medicine to sum up of the present invention can effectively be treated the nocturnal fretfulness in infants, and western medicine does not have obvious adverse reaction relatively.

Claims (9)

1. a unguentum for the treatment of the nocturnal fretfulness in infants is characterized in that, this unguentum is made by following bulk drugs:

Fructus Trichosanthis 10-30, Squama Manis 10-30, Caulis Lonicerae 10-30, Olibanum 10-30, Myrrha 10-30, Herba Patriniae 10-30, Radix Et Rhizoma Rhei 10-30, Fructus Capsici 20-40.

2. unguentum as claimed in claim 1 is characterized in that, this unguentum is made by following bulk drugs:

Fructus Trichosanthis 10, Squama Manis 30, Caulis Lonicerae 10, Olibanum 30, Myrrha 10, Herba Patriniae 30, Radix Et Rhizoma Rhei 10, Fructus Capsici 40.

3. unguentum as claimed in claim 1 is characterized in that, this unguentum is made by following bulk drugs:

Fructus Trichosanthis 30, Squama Manis 10, Caulis Lonicerae 30, Olibanum 10, Myrrha 30, Herba Patriniae 10, Radix Et Rhizoma Rhei 30, Fructus Capsici 20.

4. unguentum as claimed in claim 1 is characterized in that, this unguentum is made by following bulk drugs:

Fructus Trichosanthis 20, Squama Manis 20, Caulis Lonicerae 20, Olibanum 20, Myrrha 20, Herba Patriniae 20, Radix Et Rhizoma Rhei 20, Fructus Capsici 30.

5. unguentum as claimed in claim 1 is characterized in that, this unguentum is made by following bulk drugs:

Fructus Trichosanthis 15, Squama Manis 15, Caulis Lonicerae 15, Olibanum 15, Myrrha 15, Herba Patriniae 15, Radix Et Rhizoma Rhei 15, Fructus Capsici 20.

6. unguentum as claimed in claim 1 is characterized in that, this unguentum is made by following bulk drugs:

Fructus Trichosanthis 22, Squama Manis 18, Caulis Lonicerae 20, Olibanum 26, Myrrha 17, Herba Patriniae 19, Radix Et Rhizoma Rhei 20, Fructus Capsici 32.

7. as each described unguentum among the claim 1-6, it is characterized in that Olibanum is an Olibanum (processed) in the described crude drug, Myrrha is a Myrrha (processed), and Squama Manis is stir-baked SQUAMA MANITIS or vinegar Squama Manis.

8. as the preparation method of arbitrary described unguentum among the claim 1-6, it is characterized in that may further comprise the steps:

1) takes by weighing Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Olibanum, Myrrha, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici in proportion, clean, pulverize;

2) with Fructus Trichosanthis, Squama Manis, Caulis Lonicerae, Herba Patriniae, Radix Et Rhizoma Rhei, Fructus Capsici, add in the Oleum Sesami, heating, the literary composition back is military earlier for firepower, treat that medical material becomes black after, pull medical material out;

3) continue with the oil heating, to thickness;

4) add the substrate pharmaceutically accepted, continue heating, provoke splashing into to become in the cold water pearl and get final product to ointment with Glass rod;

5) ointment of step 4) gained is poured in the cold water while hot, attention is not arrived agglomerating, is dispersed into strip as far as possible; Soak 2-3 days in cold water after, cold water inclines;

6) Olibanum, Myrrha are ground into fine powder, and be standby;

7) with the ointment heating and melting of step 5) gained, add the fine powder of step 6) gained, stir, be uniformly coated on thick cloth or the paper, promptly.

9. preparation method as claimed in claim 8, wherein the described substrate of step 4) is Plumbum preparatium or Cera Flava, and its weight portion is 20, and the weight portion of used Oleum Sesami is 500.