CN101613333A - A kind of preparation method of apigenin and application - Google Patents
A kind of preparation method of apigenin and application Download PDFInfo
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- CN101613333A CN101613333A CN200810127091A CN200810127091A CN101613333A CN 101613333 A CN101613333 A CN 101613333A CN 200810127091 A CN200810127091 A CN 200810127091A CN 200810127091 A CN200810127091 A CN 200810127091A CN 101613333 A CN101613333 A CN 101613333A
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- apigenin
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- celery seed
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Abstract
The present invention relates to a kind of preparation method of apigenin, after celery seed is screened, pulverizes, insert content and be in 70% the alcohol container, after the stirring, leave standstill; Powdered celery seed and alcohol merge the back by the Powdered particulate state that becomes; Divide and three times the granular mixture in the container to be extracted, each timed interval of extracting is two hours; Particulate matter after the extraction is filtered through solution, and through after decompression and the concentration, thereby make pulverous refining apigenin, the purity of extracting the refining apigenin in back is 98%.Being applied to of present method is made pulverous apigenin and buttery fish oil, and incapsulates inside, and the weight in every capsules after the proportioning raw materials is 500mg, and apigenin is 150-200mg, and fish oil is 300-350mg.The present invention have blood pressure regulation, regulating blood fat, anti-oxidant, improve immunizing power and effect such as delay senility.
Description
Technical field
The present invention relates to field of health care products, especially a kind of preparation method of apigenin and application.
Background technology
Apigenin (apigenin) belongs to chromocor compound, at samphire celery (Apiumgraveolensvar.dulce) leaf; Selaginaceae Selaginella tamariscina (Selaginella tamariscina) herb; Content in Cupressaceae Chinese juniper (Sabinachinenesis) leaf is abundanter.Apigenin is present in the various plants with the form of plant yellow pigment, and pure product outward appearance is a yellow powder, and nothing is smelt tasteless, is a kind of natural antioxidants.According to the literature, apigenin, the effect that influence maincenter spirit, antiviral, inhibitory enzyme activity, Green Tea Extract hypotensive according to having.
Yet operation related among the existing apigenin preparation method is comparatively complicated, and the apigenin purity of being obtained is lower, raw-materially consumes excessively and wastes thereby caused.In addition, in existing apigenin application process, because the purity of existing apigenin is lower, made capsule or other health product for treating and health-care effect are undesirable.
Summary of the invention
The purpose of this invention is to provide the preparation method of a kind of apigenin that can access higher degree, and have blood pressure regulation, regulating blood fat, anti-oxidant, and can improve the apigenin soft capsule of immunizing power and effects such as delaying senility.
For achieving the above object, the invention provides a kind of preparation method of apigenin, may further comprise the steps:
A, celery seed screened, pulverizes after, insert content and be in 70% the alcohol container, after the stirring, leave standstill;
B, Powdered celery seed and alcohol merge the back by the Powdered particulate state that becomes;
C, divide and three times the granular mixture in the container to be extracted, each timed interval of extracting is two hours;
Particulate matter after d, the extraction is filtered through solution, and through after decompression and the concentration, thereby make pulverous refining apigenin.
The withdrawal ratio of described celery seed and described apigenin is 150: 1.
The purity of described refining apigenin is 98%.
Another object of the present invention provides a kind of apigenin soft capsule, be made by pulverous apigenin and buttery fish oil, and incapsulate inside, the weight in every capsules after the proportioning raw materials is 500mg, described apigenin is 150-200mg, and described fish oil is 300-350mg.
The content of described apigenin is 150mg, and the content of described fish oil is 350mg.
The content of described apigenin is 180mg, and the content of described fish oil is 320mg.
The content of described apigenin is 200mg, and the content of described fish oil is 300mg.
Compared with prior art, the present invention has the following advantages:
The invention provides a kind of preparation method of apigenin, after celery seed is screened, pulverizes, insert content and be in 70% the alcohol container, after the stirring, leave standstill; Powdered celery seed and alcohol merge the back by the Powdered particulate state that becomes; Divide and three times the granular mixture in the container to be extracted, each timed interval of extracting is two hours; Particulate matter after the extraction is filtered through solution, and through after decompression and the concentration, thereby make pulverous refining apigenin, the purity of extracting the refining apigenin in back is 98%.Being applied as of present method is made pulverous apigenin and buttery fish oil, and incapsulates inside, and the weight in every capsules after the proportioning raw materials is 500mg, and apigenin is 150-200mg, and fish oil is 300-350mg.The present invention have blood pressure regulation, regulating blood fat, anti-oxidant, improve immunizing power and effect such as delay senility, take body health benefits for a long time; In addition, the employing celery seed is a main raw material, and the tool low price because raw material is easy to get has also been avoided raw-material waste when improving product purity, also reduced tooling cost.
Embodiment
The working method of apigenin is:
A, celery seed screened, pulverizes after, insert content and be in 70% the alcohol container, after the stirring, leave standstill;
B, Powdered celery seed and alcohol merge the back by the Powdered particulate state that becomes;
C, divide and three times the granular mixture in the container to be extracted, each timed interval of extracting is two hours;
Particulate matter after d, the extraction is filtered through solution, and through after decompression and the concentration, thereby make pulverous refining apigenin.
The withdrawal ratio of celery seed and described apigenin is 150: 1.
The purity of refining apigenin is 98%.
The physiologically active substance that has in the apigenin mainly comprises: multiple materials such as Flavonoid substances, polyunsaturated fatty acid, mineral element, chlorophyll, butylbenzene phthaleins, amino acid, terpene, tonka-bean derivative, food fibre.
Embodiment 1:
Prepare after pulverous apigenin and buttery fish oil put into whipping appts, apigenin and fish oil can fully be merged obtain mixture, and incapsulate inside.Weight in every capsules after the proportioning raw materials is 500mg, and wherein, apigenin is 150mg, and fish oil is 350mg.
Embodiment 2:
Prepare after pulverous apigenin and buttery fish oil put into whipping appts, apigenin and fish oil can fully be merged obtain mixture, and incapsulate inside.Weight in every capsules after the proportioning raw materials is 500mg, and wherein, apigenin is 180mg, and fish oil is 320mg.
Embodiment 3:
Prepare after pulverous apigenin and buttery fish oil put into whipping appts, apigenin and fish oil can fully be merged obtain mixture, and incapsulate inside.Weight in every capsules after the proportioning raw materials is 500mg, and wherein, apigenin is 200mg, and fish oil is 300mg.
Case 1:
The main component of apigenin is: Fructus Hippophae flavone, and the pharmacological action of Fructus Hippophae flavone is: promoting blood circulation and removing blood stasis resisting myocardial ischemia, reduce myocardium keto consumption, promote myocardial function.Be used for the treatment of ischemic heart disease, alleviate heart strand disease and myocardial ischemia, reducing cholesterol and triglyceride.
35 routine high blood viscosity patients are treated, oral once a day, each one, treated for six weeks after.Found that before data such as cholesterol, triacylglycerol, blood viscosity, platelet aggregation degree and thrombus index are all treated remarkable decline is arranged.Show take this capsule after, majority parameters all has decline.
Case 2:
101 routine hypertension, hyperlipemic patients are treated, and clinical efficacy shows, is 96.13% to the effective treatment rate of hypertension, and reducing hyperlipidemia efficient is 87.15%, shows that this capsule for treating and control have tangible vital role.
Only the above person only is preferred embodiment of the present invention, is familiar with the professional person of this skill such as. after understanding technique means of the present invention, natural energy is changed under instruction of the present invention according to the needs of reality.Therefore all equal variation and modifications of being done according to the present patent application claim once should still belong in the scope that patent of the present invention contains.
Claims (7)
1, a kind of preparation method of apigenin is characterized in that, may further comprise the steps:
A, celery seed screened, pulverizes after, insert content and be in 70% the alcohol container, after the stirring, leave standstill;
B, Powdered celery seed and alcohol merge the back by the Powdered particulate state that becomes;
C, divide and three times the granular mixture in the container to be extracted, each timed interval of extracting is two hours;
Particulate matter after d, the extraction is filtered through solution, and through after decompression and the concentration, thereby make pulverous refining apigenin.
2, the preparation method of a kind of apigenin as claimed in claim 1 is characterized in that, the withdrawal ratio of described celery seed and described apigenin is 150: 1.
3, the preparation method of a kind of apigenin as claimed in claim 1 is characterized in that, the purity of described refining apigenin is 98%.
4, a kind of apigenin soft capsule is characterized in that, is made by pulverous apigenin and buttery fish oil, and incapsulate inside, weight in every capsules after the proportioning raw materials is 500mg, and described apigenin is 150-200mg, and described fish oil is 300-350mg.
5, a kind of apigenin soft capsule as claimed in claim 4 is characterized in that, the content of described apigenin is 150mg, and the content of described fish oil is 350mg.
6, a kind of apigenin soft capsule as claimed in claim 4 is characterized in that, the content of described apigenin is 180mg, and the content of described fish oil is 320mg.
7, a kind of apigenin soft capsule as claimed in claim 4 is characterized in that, the content of described apigenin is 200mg, and the content of described fish oil is 300mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN200810127091A CN101613333A (en) | 2008-06-25 | 2008-06-25 | A kind of preparation method of apigenin and application |
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| CN200810127091A CN101613333A (en) | 2008-06-25 | 2008-06-25 | A kind of preparation method of apigenin and application |
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| CN101613333A true CN101613333A (en) | 2009-12-30 |
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| CN200810127091A Pending CN101613333A (en) | 2008-06-25 | 2008-06-25 | A kind of preparation method of apigenin and application |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101978979A (en) * | 2010-11-03 | 2011-02-23 | 隋焕平 | Method for preparing refined celery extract |
| CN102020695A (en) * | 2010-10-11 | 2011-04-20 | 中国科学院新疆理化技术研究所 | Method for extracting natural active protein and polypeptide from celery seeds |
| CN102048775A (en) * | 2010-12-09 | 2011-05-11 | 北京人福军威医药技术开发有限公司 | Celery seed extract composition and preparation method thereof |
| CN102225083A (en) * | 2011-06-20 | 2011-10-26 | 施慧达药业集团(吉林)有限公司 | Pharmaceutical composition and application thereof |
| CN103641807A (en) * | 2013-12-25 | 2014-03-19 | 南通大学 | Extraction method of apigenin, pharmaceutical composition for treating diabetes and application thereof |
| CN105380031A (en) * | 2014-09-05 | 2016-03-09 | 深圳华大基因研究院 | Health food and preparation method thereof |
| CN105907475A (en) * | 2016-06-13 | 2016-08-31 | 江西中烟工业有限责任公司 | Tobacco flavor capable of reducing hazardous substance in smoke and bobbin paper containing same |
| CN106389489A (en) * | 2016-09-20 | 2017-02-15 | 青海清华博众生物技术有限公司 | Celery-seed extract and extracting method and application thereof |
| CN106905279A (en) * | 2017-01-19 | 2017-06-30 | 中国农业大学 | A kind of extracting method of Chinese herbaceous peony antioxidation composition |
| CN108771070A (en) * | 2018-06-20 | 2018-11-09 | 西安巨子生物基因技术股份有限公司 | The complex function drink and preparation method and purposes of coronoid process dissipate capsule bacterium ferment celery juice |
| CN113893269A (en) * | 2021-10-05 | 2022-01-07 | 浙江省农业科学院 | Preparation and purification method of celery seed extracting solution with blood pressure lowering effect |
-
2008
- 2008-06-25 CN CN200810127091A patent/CN101613333A/en active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020695A (en) * | 2010-10-11 | 2011-04-20 | 中国科学院新疆理化技术研究所 | Method for extracting natural active protein and polypeptide from celery seeds |
| CN102020695B (en) * | 2010-10-11 | 2013-03-13 | 中国科学院新疆理化技术研究所 | Method for extracting natural active protein and polypeptide from celery seeds |
| CN101978979A (en) * | 2010-11-03 | 2011-02-23 | 隋焕平 | Method for preparing refined celery extract |
| CN102048775A (en) * | 2010-12-09 | 2011-05-11 | 北京人福军威医药技术开发有限公司 | Celery seed extract composition and preparation method thereof |
| CN102048775B (en) * | 2010-12-09 | 2012-11-07 | 北京人福军威医药技术开发有限公司 | Celery seed extract composition and preparation method thereof |
| CN102225083A (en) * | 2011-06-20 | 2011-10-26 | 施慧达药业集团(吉林)有限公司 | Pharmaceutical composition and application thereof |
| CN102225083B (en) * | 2011-06-20 | 2013-01-16 | 施慧达药业集团(吉林)有限公司 | Pharmaceutical composition for treating hypertension and hyperlipidemia, and application thereof |
| CN103641807B (en) * | 2013-12-25 | 2015-12-09 | 南通大学 | A kind of extracting method of apigenin, the pharmaceutical composition being used for the treatment of diabetes and application thereof |
| CN103641807A (en) * | 2013-12-25 | 2014-03-19 | 南通大学 | Extraction method of apigenin, pharmaceutical composition for treating diabetes and application thereof |
| CN105380031A (en) * | 2014-09-05 | 2016-03-09 | 深圳华大基因研究院 | Health food and preparation method thereof |
| CN105907475A (en) * | 2016-06-13 | 2016-08-31 | 江西中烟工业有限责任公司 | Tobacco flavor capable of reducing hazardous substance in smoke and bobbin paper containing same |
| CN106389489A (en) * | 2016-09-20 | 2017-02-15 | 青海清华博众生物技术有限公司 | Celery-seed extract and extracting method and application thereof |
| CN106905279A (en) * | 2017-01-19 | 2017-06-30 | 中国农业大学 | A kind of extracting method of Chinese herbaceous peony antioxidation composition |
| CN106905279B (en) * | 2017-01-19 | 2019-03-22 | 中国农业大学 | A kind of extracting method of Chinese herbaceous peony antioxidation ingredient |
| CN108771070A (en) * | 2018-06-20 | 2018-11-09 | 西安巨子生物基因技术股份有限公司 | The complex function drink and preparation method and purposes of coronoid process dissipate capsule bacterium ferment celery juice |
| CN108771070B (en) * | 2018-06-20 | 2022-02-08 | 西安巨子生物基因技术股份有限公司 | Compound functional beverage prepared by fermenting celery juice with eurotium cristatum, preparation method and application |
| CN113893269A (en) * | 2021-10-05 | 2022-01-07 | 浙江省农业科学院 | Preparation and purification method of celery seed extracting solution with blood pressure lowering effect |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jilin Province Weiyi Bioengineering Co., Ltd. Assignor: Jilin Shuzhen Trade Co., Ltd. Contract fulfillment period: 2009.4.8 to 2014.4.8 contract change Contract record no.: 2009220000003 Denomination of invention: Method preparing apigenin and application thereof License type: Exclusive license Record date: 2009.4.20 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.4.8 TO 2014.4.8; CHANGE OF CONTRACT Name of requester: JILIN PROVINCE WEIYI BIOLOGICAL ENGINEERING CO., L Effective date: 20090420 |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091230 |