CN101607035A - A kind of pharmaceutical composition that is used for the treatment of infantile acute bronchitis - Google Patents
A kind of pharmaceutical composition that is used for the treatment of infantile acute bronchitis Download PDFInfo
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- CN101607035A CN101607035A CNA2009100673250A CN200910067325A CN101607035A CN 101607035 A CN101607035 A CN 101607035A CN A2009100673250 A CNA2009100673250 A CN A2009100673250A CN 200910067325 A CN200910067325 A CN 200910067325A CN 101607035 A CN101607035 A CN 101607035A
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Abstract
The present invention relates to a kind of pharmaceutical composition that is used for the treatment of infantile acute bronchitis, belong to Chinese medicine.Include active substance: Chelidonine 30-60 part, Fructus Trichosanthis ethanol extract 15-35 part, Rhizoma Pinelliae ethanol extract 5-20 part, Bulbus Fritillariae Ussuriensis total saponins 10-30 part by following weight fraction ratio.Be used for heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, the treatment phlegm-fire is stopped up lung, the expectoration Huang is thick or sputum mixed with blood, distending pain in the chest and hypochondrium and intimately bright lung stagnation of phlegm air flue are cough caused.
Description
Technical field
The invention belongs to Chinese medicine, refer in particular to and be used for heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, the treatment phlegm-fire stop up lung, expectoration yellow thick or sputum mixed with blood, distending pain in the chest and hypochondrium and the lung stagnation of phlegm air flue that intimately burns cough caused.
Background technology
Acute bronchitis is a common disease of the clinical respiratory system of children's, Chang Bingfa or be secondary to lower respiratory infection, and be a kind of clinical manifestation of measles, pertussis, typhoid fever and other acute infectious disease.When bronchitis took place, trachea is inflammation simultaneously mostly, if relate to the capillary bronchus, then its pathology and symptom are all similar with pneumonia.In tcm clinical practice, belong to " cough " category more.Motherland's medical science is thought, wind-heat invading the lung, and impairment of purifying function of the lung, heat is endured body fluid, so cough expectorant is yellow and thick, or cough with difficulty in expectoration; Evil objective fur is so there is the function exterior syndrome of headache, aversion to cold, heating; Lung opening at nose, throat is the door of breathing, heat stagnation is in lung, disturbance of lung-QI, so see nasal obstruction, sneeze is had sore throat, hoarseness; The bright lung network of heat, network is hindered then escape of blood from meridians, and sees the sputum mixed with blood silk; Impairment of dispersing and descending function of the lung involves taste, and QI rising in reverse order is nausea and vomiting then; The stagnation of phlegm chest and diaphragm, disorder of QI movement, thereby cough then breast abdomen pain, treatment should be based on the transconversion into heat expectorant lung qi dispersing cough-relieving of dispelling.
Present more to the treatment antibiotic of infantile acute bronchitis and chemical drugs, but because of problems such as drug resistance and toxic and side effects, be difficult to treatment, primary disease does not still have ideal treatment medicine at present, especially antibacterial to the pathogenic bacterium that infect, human body immunity improving power reduces the desirable medicine that recurs, and still remains to be developed.Because of infantile acute bronchitis is a kind of common clinical, outbreak more can not cause chronic asthmatic bronchitis repeatedly, jeopardizes the healthy and growth of infant.Need for this reason that curative effect is rapid, effect is certain, have no side effect, can prevent recurrence, but and the medicine taken of longer-term.
Summary of the invention
The invention provides a kind of pharmaceutical composition that is used for the treatment of infantile acute bronchitis, be used for heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, the treatment phlegm-fire is stopped up lung, the expectoration Huang is thick or sputum mixed with blood, distending pain in the chest and hypochondrium and intimately bright lung stagnation of phlegm air flue are cough caused.The technical scheme that the present invention takes is: include the active substance by following weight fraction ratio:
Chelidonine 30-60 part, Fructus Trichosanthis ethanol extract 15-35 part, Rhizoma Pinelliae ethanol extract 5-20 part, Bulbus Fritillariae Ussuriensis total saponins 10-30 part.
Be preferably:
45 parts of Chelidonines, 25 parts of Fructus Trichosanthis ethanol extract, 12.5 parts of Rhizoma Pinelliae ethanol extract, 20 parts of Bulbus Fritillariae Ussuriensis total saponins.
Above-mentioned various extracts among the present invention can be preferably by extracting method acquisition arbitrarily in the prior art:
Chelidonine: it is an amount of to take by weighing raw material, adds 5-14 times of ethanol and decocts 0.5-3 hour in that the 50%-90% of 3-6 alcohol reflux 1-3 time is each with pH, filter, and merging filtrate, concentrated.
The Fructus Trichosanthis ethanol extract: take by weighing that to be crushed to 60 purpose raw materials an amount of, add 6-15 times of ethanol and decocted 0.5-3 hour, filter with 50%-90% alcohol reflux 1-3 time is each, merging filtrate, concentrated.
Rhizoma Pinelliae ethanol extract: it is an amount of to take by weighing raw material, adds 7-18 times of ethanol and decocts 0.5-3 hour with 50%-90% alcohol reflux 1-3 time is each, filter, and merging filtrate, concentrated.
The Bulbus Fritillariae Ussuriensis total saponins: it is an amount of to take by weighing raw material, adds 8-20 times of ethanol and decocts 0.5-3 hour with 50%-90% alcohol reflux 1-3 time is each, filter, and merging filtrate, concentrated.
The present invention can be mixed with medicament with one or more pharmaceutically acceptable carriers or adjuvant.
Above-mentioned pharmaceutically acceptable carrier is meant the pharmaceutical carrier or the adjuvant of pharmaceutical field routine, for example: diluent, excipient and water etc., filler such as starch, dextrin, sucrose, mannitol, lactose, microcrystalline Cellulose etc.; Binding agent such as cellulose derivative, alginate, gelatin and polyvinylpyrrolidone; Wetting agent such as glycerol: disintegrating agent such as methyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate and sodium bicarbonate; Absorption enhancer such as quaternary ammonium compound; Surfactant such as hexadecanol, Tween 80, sodium lauryl sulphate; Alms bowl such as Kaolin and soap clay are carried in absorption; Lubricant such as Pulvis Talci, calcium stearate and magnesium, micropowder silica gel and Polyethylene Glycol etc.In medicament, can also contain other adjuvant such as flavouring agent, sweeting agent etc. in addition.
The medicament that the present invention makes can be applied to the patient by the mode of oral, rectum or parenteral.Be used for when oral, can be made into conventional solid preparation such as tablet, capsule, powder, granule etc., make other liquid preparation of liquid preparation such as water or oil-suspending agent such as syrup, mixture, elixir etc.; When being used for parenteral, can be made into solution, powder pin, water or the oiliness suspending agent etc. of injection.The preferred form of the present invention is oral liquid, tablet, coated tablet, capsule, granule.
The present invention is used for heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, and the treatment phlegm-fire is stopped up lung, the expectoration Huang is thick or sputum mixed with blood, distending pain in the chest and hypochondrium and intimately bright lung stagnation of phlegm air flue are cough caused.The amount of application of the present invention and medicament thereof can be according to variations such as the type of route of administration, patient age, body weight, the disease of being treated and the orders of severity, and is oral, in six months, and a 1-5ml; Seven to 12 months, a 5-15ml; One to three years old one time 20ml; Three to six years old one time 20-25ml; Six years old to nine years old one time 25-30ml; Nine years old with last 30-50ml; 3 times on the one.
The specific embodiment
Further verify the present invention below by Pharmacodynamic test of active extract.
Experiment material
1.1, medicine medicine of the present invention, hereinafter to be referred as the white sichuan fritillary bulb cough-arresting syrup of children's, grass also red Pharmaceutical lot number 040508 in Jilin contains crude drug 0.2g/ml; Histamine, Shanghai biological chemical reagent head factory; The infantile heat-clearing and antitussive oral liquid, Zhejiang Kang Enbei pharmaceutical Co. Ltd, lot number 04092; Dry yeast, DongTang Group Danbaoli Yeast Factory, Dongguan City, lot number: 031106, dimethylbenzene, Shenyang City's reagent one factory; Ammonia, sodium chloride, Shenyang chemical reagent factory.
1.2, the animal kunming mice, male and female hold concurrently half, body weight 18-22g; The Wistar rat, body weight 170-200g, Cavia porcellus 250-300g provide by Jilin University's Experimental Animal Center.
Experimental technique
2.1 antitussive experiment
Cough 50 of method mices 2.1.1 mice ammonia draws, the male and female dual-purpose is divided into 5 groups, irritates stomach respectively and gives the white sichuan fritillary bulb cough-arresting syrup 2ml/kg of children's, 5ml/kg, 10ml/kg, positive control drug infantile heat-clearing and antitussive oral liquid 5.36ml/kg; Normal saline is made blank, and 30min relief mice is accepted the constant voltage ammonia spraying, observes the interior mouse cough number of times of 3min and the results are shown in Table 1.
The white sichuan fritillary bulb cough-arresting syrup of table 1 children's is to the antitussive effect (n=10) of mice
★P＜0.05，
★★P＜0.01
2.1.2 drawing, Cavia porcellus ammonia coughs 30 of method Cavia porcelluss, be divided into 5 groups, irritate stomach respectively and give the white sichuan fritillary bulb cough-arresting syrup 2ml/kg of children's, 5ml/kg, 10ml/kg, positive control drug infantile heat-clearing and antitussive oral liquid 5.36ml/kg, normal saline is made blank and is accepted constant voltage ammonia spraying 30s by Cavia porcellus and draw and cough, the cough number of times the results are shown in Table 2 in the record 3min.
The white sichuan fritillary bulb cough-arresting syrup of table 2 children's is to the antitussive effect (n=6) of Cavia porcellus
★ ★P＜0.01 is compared with matched group
The results are shown in Table 1 table 2 and show that the white sichuan fritillary bulb cough-arresting syrup of children's draws the method for coughing to the ammonia of mice, Cavia porcellus good antitussive effect is arranged.
The experiment 2.2 eliminate the phlegm
The phenol red drainage method of mice
Get 75 of Kunming mouses, laboratory adapts to 3d, is divided into 5 groups at random by sex, body weight, 15 every group, is respectively the normal saline matched group, the high, medium and low dosage group of infantile heat-clearing and antitussive oral liquid matched group and children's Bai Bei cough stopping oral liquor.Irritate the corresponding medicinal liquid of stomach (its capacity is 0.2mg/10g) respectively, every day 1 time, 7d continuously.15h after the last administration, each organizes the phenol red normal saline 0.1ml/10g of the equal lumbar injection 5% of mice, animal is put to death in dislocation behind the 30min, peel off the trachea surrounding tissue, cut one section trachea down to the trachea crotch from thyroid cartilage, put into the test tube that fills the 2ml normal saline, add the sodium hydroxide of 0.1ml 5% again.With 722 type spectrophotometers, survey the OD value at wavelength 540nm place, with the phenol red standard curve of doing, calculate phenol red content (μ g/ml) according to standard curve, see Table 1.The result shows that the high, medium and low dosage group of children's Bai Bei cough stopping oral liquor all has the phenol red effect of the trachea excretion of enhancing, and phlegm-dispelling functions is arranged.
The phlegm-dispelling functions of table 3 children's Bai Bei cough stopping oral liquor
Compare with matched group
★P＜0.05,
★ ★P＜0.01,
★ ★ ★P＜0.001
2.3 the white sichuan fritillary bulb cough-arresting syrup of children's is to the influence of rat fever due to the dry yeast
Get 50 male and female half and half of the healthy Wistar rat of body weight 170-200g, be divided into 5 groups every group 10.Adapt to 3d in laboratory environment, survey the anus temperature every day 2 times.Irritate stomach respectively and give the white sichuan fritillary bulb cough-arresting syrup 2ml/kg of children's, 5ml/kg, 10ml/kg, infantile heat-clearing and antitussive oral liquid 5.36ml/kg, normal saline, successive administration 3d, the same day was per hour surveyed body temperature 1 time in experiment, select for use the body temperature variation to be no more than 0.3 ℃ rat confession experiment usefulness continuous 2 times, 8 every group, getting its average is normal body temperature.Immediately in rat back subcutaneous injection 0.2g/L dry yeast normal saline solution 10mg/kg, measure the body temperature 1 time of rat after the perfusion, body temperature after the pyrogenicity is deducted mean body temperature before the medicine, as the body temperature changing value respectively at injection back 0.5,1,2,4,6,8,10h.
Can significantly reduce the body temperature of heating rat due to the dry yeast as can be known behind the white sichuan fritillary bulb cough-arresting syrup high dose of the children's 15ml/kg group 2h by table 4 result, and this effect continues up to 10h, with positive drug group each time point there are no significant difference relatively; In dosage 10ml/kg group when 4h, can significantly reduce the body temperature rise of rat, effect lasts till 10h, with the positive drug group relatively except that 1h, other each time points there are no significant difference; 5ml/kg group also has the effect that reduces heat production, but effect not as above two groups obvious.
2.4 antiinflammatory action
The influence of xylol induced mice inflammation
Method: 50 of mices, male and female dual-purpose, body weight 18-22g, be divided into 5 groups, give the white sichuan fritillary bulb cough-arresting syrup 2ml/kg of children's, 5ml/kg, 10ml/kg respectively, make blank with normal saline, 100mg/kg does positive control with aspirin, evenly coat xylene solution 0.03ml in left auricle both sides behind the administration 15min, auris dextra compares, and behind the 2h, the auricle of cut-off footpath 7.5mm is weighed, with the two auricle method of double differences is auricle swelling degree, carries out statistical procedures.
The result shows that the auricle swelling degree of blank group is (7.7 ± 2.8) mg, the white sichuan fritillary bulb cough-arresting syrup low dosage of children's 1g/kg group is 2.7 ± 2.0, middle dosage 2g/kg group is 2.6 ± 1.2, high dose 4g/kg group is 2.3 ± 1.1, illustrate that the white sichuan fritillary bulb cough-arresting syrup of children's can obviously suppress the mice auricle swelling (P＜0.01) due to the dimethylbenzene, has antiinflammatory action.
The white sichuan fritillary bulb cough-arresting syrup of table 5 children's is to the influence of mice inflammation
★ ★P＜0.01 is compared with matched group
Result of study shows that the white sichuan fritillary bulb cough-arresting syrup of children's draws the method for coughing to the ammonia of mice and Cavia porcellus tangible antitussive effect is arranged, and can increase trachea phenol red output has phlegm-dispelling functions.The rat fever that dry yeast is caused has stronger inhibitory action, and xylol causes the mice ankle swelling also the obvious suppression effect, illustrates that the white sichuan fritillary bulb cough-arresting syrup of children's has significant antiinflammatory action.
More than explanation children's white sichuan fritillary bulb cough-arresting syrup tangible antitussive arranged, eliminate the phlegm, heat clearing away and antiinflammatory action, clinical practice in the children cough that a variety of causes causes cough up phlegm, heating paresthesia, it is alleviated.
Embodiment 1
Chelidonine 30g, Fructus Trichosanthis ethanol extract 15g, Rhizoma Pinelliae ethanol extract 5g, Bulbus Fritillariae Ussuriensis total saponins 10g.
Add the conventional adjuvant of preparation tablet, make tablet.
Above-mentioned various extracts among the present invention can be preferably by extracting method acquisition arbitrarily in the prior art:
Chelidonine: it is an amount of to take by weighing raw material, adds 5-14 times of ethanol and decocts 0.5-3 hour in that the 50%-90% of 3-6 alcohol reflux 1-3 time is each with pH, filter, and merging filtrate, concentrated.
The Fructus Trichosanthis ethanol extract: take by weighing that to be crushed to 60 purpose raw materials an amount of, add 6-15 times of ethanol and decocted 0.5-3 hour, filter with 50%-90% alcohol reflux 1-3 time is each, merging filtrate, concentrated.
Rhizoma Pinelliae ethanol extract: it is an amount of to take by weighing raw material, adds 7-18 times of ethanol and decocts 0.5-3 hour with 50%-90% alcohol reflux 1-3 time is each, filter, and merging filtrate, concentrated.
The Bulbus Fritillariae Ussuriensis total saponins: it is an amount of to take by weighing raw material, adds 8-20 times of ethanol and decocts 0.5-3 hour with 50%-90% alcohol reflux 1-3 time is each, filter, and merging filtrate, concentrated.
Embodiment 2
Chelidonine 45g, Fructus Trichosanthis ethanol extract 25g, Rhizoma Pinelliae ethanol extract 12.5g, Bulbus Fritillariae Ussuriensis total saponins 20g.
Add the conventional adjuvant of preparation cough syrup, make 50 bottles, every bottle of 10ml contains crude drug 0.2g/ml.
Embodiment 3
Chelidonine 60g, Fructus Trichosanthis ethanol extract 35g, Rhizoma Pinelliae ethanol extract 20g, Bulbus Fritillariae Ussuriensis total saponins 30g.
Add the conventional adjuvant of preparation preparation granule, make granule.
Claims (2)
1, a kind of pharmaceutical composition that is used for the treatment of infantile acute bronchitis, it is characterized in that: include active substance: Chelidonine 30-60 part by following weight fraction ratio, Fructus Trichosanthis ethanol extract 15-35 part, Rhizoma Pinelliae ethanol extract 5-20 part, Bulbus Fritillariae Ussuriensis total saponins 10-30 part.
2, the pharmaceutical composition that is used for the treatment of infantile acute bronchitis according to claim 1, it is characterized in that: include active substance: 45 parts of Chelidonines by following weight fraction ratio, 25 parts of Fructus Trichosanthis ethanol extract, 12.5 parts of Rhizoma Pinelliae ethanol extract, 20 parts of Bulbus Fritillariae Ussuriensis total saponins.
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| CN2009100673250A CN101607035B (en) | 2009-07-17 | 2009-07-17 | Pharmaceutical composition for treating acute bronchitis in children |
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| CN2009100673250A CN101607035B (en) | 2009-07-17 | 2009-07-17 | Pharmaceutical composition for treating acute bronchitis in children |
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| CN101607035B CN101607035B (en) | 2012-01-04 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793841A (en) * | 2012-08-20 | 2012-11-28 | 孔庆玉 | Traditional Chinese medicine composition for treating pediatric acute bronchitis |
| CN108245611A (en) * | 2018-02-24 | 2018-07-06 | 河南中医药大学第附属医院 | A kind of moxibustion powder for treating asthenia of pulmonosplenic qi cough and its preparation method and application |
-
2009
- 2009-07-17 CN CN2009100673250A patent/CN101607035B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793841A (en) * | 2012-08-20 | 2012-11-28 | 孔庆玉 | Traditional Chinese medicine composition for treating pediatric acute bronchitis |
| CN102793841B (en) * | 2012-08-20 | 2013-11-20 | 孔庆玉 | Traditional Chinese medicine composition for treating pediatric acute bronchitis |
| CN108245611A (en) * | 2018-02-24 | 2018-07-06 | 河南中医药大学第附属医院 | A kind of moxibustion powder for treating asthenia of pulmonosplenic qi cough and its preparation method and application |
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| CN101607035B (en) | 2012-01-04 |
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Denomination of invention: Pharmaceutical composition for treating acute bronchitis in children Effective date of registration: 20191022 Granted publication date: 20120104 Pledgee: Jilin nine rural commercial bank Limited by Share Ltd. Changchun branch Pledgor: JILIN CAOHUANDAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2019220000025 |
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