CN101606906B - 熊去氧胆酸纳米混悬剂及其制备方法 - Google Patents
熊去氧胆酸纳米混悬剂及其制备方法 Download PDFInfo
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- CN101606906B CN101606906B CN 200910158235 CN200910158235A CN101606906B CN 101606906 B CN101606906 B CN 101606906B CN 200910158235 CN200910158235 CN 200910158235 CN 200910158235 A CN200910158235 A CN 200910158235A CN 101606906 B CN101606906 B CN 101606906B
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- nano suspension
- ursodeoxycholic acid
- acid nano
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- pvp
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- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 title claims abstract description 75
- 229960001661 ursodiol Drugs 0.000 title claims abstract description 75
- 239000006070 nanosuspension Substances 0.000 title claims abstract description 60
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title abstract description 21
- 239000002245 particle Substances 0.000 claims abstract description 21
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920003081 Povidone K 30 Polymers 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 19
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 16
- 239000012153 distilled water Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 238000004945 emulsification Methods 0.000 claims description 9
- 239000003085 diluting agent Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 abstract description 8
- 238000009472 formulation Methods 0.000 abstract description 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 abstract 1
- 230000004087 circulation Effects 0.000 description 20
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 14
- 239000004141 Sodium laurylsulphate Substances 0.000 description 14
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 14
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- 206010008635 Cholestasis Diseases 0.000 description 2
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- 238000012360 testing method Methods 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 description 1
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000001246 colloidal dispersion Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
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- 238000007907 direct compression Methods 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007716 flux method Methods 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229940044519 poloxamer 188 Drugs 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 208000010157 sclerosing cholangitis Diseases 0.000 description 1
- 238000007613 slurry method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
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CN 200910158235 CN101606906B (zh) | 2009-07-23 | 2009-07-23 | 熊去氧胆酸纳米混悬剂及其制备方法 |
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CN 200910158235 CN101606906B (zh) | 2009-07-23 | 2009-07-23 | 熊去氧胆酸纳米混悬剂及其制备方法 |
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CN101606906A CN101606906A (zh) | 2009-12-23 |
CN101606906B true CN101606906B (zh) | 2012-05-30 |
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CN 200910158235 Expired - Fee Related CN101606906B (zh) | 2009-07-23 | 2009-07-23 | 熊去氧胆酸纳米混悬剂及其制备方法 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2981572B1 (fr) * | 2011-10-21 | 2018-01-19 | Inopharm Limited | Compositions pharmaceutiques d'acide ursodesoxycholique |
CN106383234B (zh) * | 2016-08-31 | 2017-11-24 | 上海科华生物工程股份有限公司 | 视黄醇结合蛋白检测试剂的包被方法 |
CN106619163A (zh) * | 2016-12-24 | 2017-05-10 | 青岛科技大学 | 光甘草定纳米混悬剂及其制备方法 |
CN107496928B (zh) * | 2017-09-11 | 2020-07-14 | 石家庄学院 | 一种熊去氧胆酸干混悬剂及其制备方法 |
EP3804702A1 (de) * | 2019-10-10 | 2021-04-14 | Bayer AG | Verfahren zur herstellung einer pharmazeutischen formulierung mit wirkstoff, polymer und tensid |
CN113975233B (zh) * | 2021-10-22 | 2023-04-18 | 北京汇诚益健医药科技有限责任公司 | 一种肠道内稳定的熊去氧胆酸纳米混悬剂的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101028274A (zh) * | 2006-03-03 | 2007-09-05 | 北京奇源益德药物研究所 | 治疗肝胆疾病的熊去氧胆酸制剂及其制备方法 |
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CN101028274A (zh) * | 2006-03-03 | 2007-09-05 | 北京奇源益德药物研究所 | 治疗肝胆疾病的熊去氧胆酸制剂及其制备方法 |
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Owner name: 302 MILITARY HOSPITAL OF CHINA Free format text: FORMER OWNER: YUAN HAILONG Effective date: 20110402 |
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Effective date of registration: 20110402 Address after: 100039 Fengtai District West Fourth Ring Road, Beijing, No. 100 Applicant after: 302 Military of China Address before: 100039 Fengtai District West Fourth Ring Road, Beijing, No. 100 Applicant before: Yuan Hailong |
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Granted publication date: 20120530 Termination date: 20200723 |
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