CN101601842B - Health care product for relieving and preventing ocular diseases and preparation method thereof - Google Patents
Health care product for relieving and preventing ocular diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health care product for relieving and preventing ocular diseases and a preparation method thereof. According to the traditional Chinese medical science, the ocular diseases including asthenopia, myopia and the like are mostly resulted from liver-blood deficiency and liver-yin and kidney-yin deficiency, therefore, the purposes of clearing away heat and toxic material, activating blood circulation and dredging collaterals as well as clearing liver and improving vision are taken as therapeutic principles. The product comprises rheum officinale, honeysuckle, chrysanthemum, sophora flavescens, Eriocaulon buergerianum Koern, rhizoma anemarrhenae, curcuma zedoary and borneol; wherein, with the functions of clearing away heat and toxic material and removing blood stasis and dredging collaterals, the rheum officinale in the prescription is regarded as a monarch drug; the honeysuckle with the functions of clearing away heat and toxic material and cooling wind-heat, the chrysanthemum and the Eriocaulon buergerianum Koern with the functions of dispelling wind-heat and soothing liver and improving vision are regarded as ministerial drugs to improve the capacity of the monarch drug in clearing away heat and toxic material; the sophora flavescens with the functions of clearing away heat and drying dampness and the rhizoma anemarrhenae with the functions of clearing away heat and reducing fire and promoting salivation and moisturizing dryness and the curcuma zedoary with the functions of promoting the circulation of qi, dissipating blood stasis and relieving pain are regarded as adjuvant drugs; besides having the functions of clearing away heat and dispelling depression, the borneol has fragrance spreading to dredge collaterals so that other drugs in the prescription are led to directly reach the affected parts, therefore, the borneol is regarded as a dispatcher drug. The product can resist inflammation, ease pain and improve microcirculation.
Description
Technical field
The present invention relates to health product of a kind of alleviation and prevention ocular disease and preparation method thereof.
Background technology
Asthenopia, ocular disease such as myopia are because after continuing closely to look thing, what occur looks ophthalmic bloated, eye is dry and astringent, causalgia, eye and eye socket symptom and headache such as ache, feel sick, the weak one group of uncomfortable syndrome of the whole body that waits, particularly along with modern science and technology, fast development of computer technology especially, TV, computer has entered office, family and all trades and professions use the crowd of computer also more and more, and computer brings not to the utmost benefit for people's life, but owing to do not note eye hygiene, also can cause the generation of various oculopathy, asthenopia, myopia etc. are exactly modal a kind of.Can cause conjunctival congestion, visual deterioration, eye adjusting power reduces lacrimal secretion minimizing etc.; Motherland's medical science is thought, asthenopia, and ocular disease such as myopia mostly are deficiency of liver-blood, and due to the hepatic and renal YIN deficiency, when with heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, liver heat removing and eyesight improving are the rule of treatment.
Summary of the invention
The object of the present invention is to provide a kind ofly have that prescription is rigorous, the compatibility science, evident in efficacy, can bring into play drug effect to a greater extent, short treating period, instant effect, easily consolidation, and can microcirculation improvement, safe in utilization, a kind of alleviation and health product of prevention ocular disease and preparation method thereof that have no side effect.
In order to achieve the above object, the technical method scheme of the present invention's employing is:
The raw materials of effective components of the health product of a kind of alleviation and prevention ocular disease forms and weight proportion is:
Radix Et Rhizoma Rhei 1490-1510 part Flos Lonicerae 1490-1510 part Flos Chrysanthemi 90-110 part
Radix Sophorae Flavescentis 490-510 part Flos Eriocauli 900-1010 part Rhizoma Anemarrhenae 490-510 part
Rhizoma Curcumae 90-110 part Borneolum Syntheticum 5-15 part.
The raw materials of effective components of the above-mentioned a kind of alleviation and the health product of prevention ocular disease forms and weight proportion is:
100 parts of 1500 parts of Flos Chrysanthemis of 1500 portions of Flos Loniceraes of Radix Et Rhizoma Rhei
500 parts of 1000 parts of Rhizoma Anemarrhenaes of 500 parts of Flos Eriocaulis of Radix Sophorae Flavescentis
10 parts of 100 parts of Borneolum Syntheticums of Rhizoma Curcumae.
The dosage form of the above-mentioned a kind of alleviation and the health product of prevention ocular disease is a patch.
The dosage form of the above-mentioned a kind of alleviation and the health product of prevention ocular disease is that the adjuvant of patch is formed and weight proportion is:
100 parts of 100 parts of Mel of 1600 parts of lanolines of vaseline
3 parts of ethyl hydroxybenzoates.
The dosage form of the above-mentioned a kind of alleviation and the health product of prevention ocular disease is that the preparation method of patch is:
Flos Chrysanthemi, the Rhizoma Curcumae cold drying is pulverized, and sieving makes into fine powder, get the Mel heating again and refine into old honey, when treating that temperature is reduced to 50～80 ℃ of left and right sides, add above-mentioned fine powder and stir, mixing, it is standby to make sweet cream, Borneolum Syntheticum, ethyl hydroxybenzoate adds ethanol and dissolves in right amount, collects the solution for standby Radix Et Rhizoma Rhei, Flos Lonicerae, Flos Eriocauli, Radix Sophorae Flavescentis, the Rhizoma Anemarrhenae add 5～10 times of water gagings and decoct twice, decoct and are respectively 0.5～3h, collecting decoction filters, filtrate decompression is concentrated into the extractum of 1.0～2.0 (60 ℃ of surveys), vaseline, lanoline heating melting is under continuous equidirectional stirring, slowly add above-mentioned extractum, continue to stir, mixing is when treating that temperature is reduced to 30～60 ℃ of left and right sides, add above-mentioned sweet cream and solution again, stir, mixing is made subsides.
The present invention is with respect to prior art, and its advantage is as follows:
The present invention is a raw material with the natural Chinese medicinal herb, has no side effect, and the effect of antiinflammatory, analgesia and microcirculation improvement is arranged.
The specific embodiment
The present invention is based on modern clinical experience, offer and source investigation, the eight flavor property of medicine in the prescription are carried out as detailed below in conjunction with long-term clinical practice and preliminary clinical research case with reference to successive dynasties doctor ancient Chinese prose:
1, Radix Et Rhizoma Rhei: be the dry root and the stem of polygonum rheum palmatum Rheum tanguticum or Rheum officinale.
Nature and flavor: hardship, cold.
Performance characteristics: intestinal, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation are led in pathogenic fire purging.Be used for the excess-heat constipation, stagnant stomachache, the not well jaundice due to damp-heat of dysentery, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, enterodynia stomachache, carbuncle furuncle, congestion amenorrhea, traumatic injury etc.
2, Flos Lonicerae: caprifoliaceae plant dry Alabastrum or just opened flower of Radix Ophiopogonis.
Nature and flavor: sweet, cold.
Performance characteristics: heat-clearing and toxic substances removing, wind-heat dissipating.Be used for the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
3, Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum.
Nature and flavor: sweet, bitter, be slightly cold.
Performance characteristics: the wind heat clearing away of loosing, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.
4, Flos Eriocauli: be the head inflorescence of the dry zone scape of Eriocaulaceae plant Flos Eriocauli.
Nature and flavor: suffering, sweet, flat.
Performance characteristics: dispelling wind and heat pathogens makes eye bright nebula removing.Be used for the wind heat conjunctival congestion, the photophobia that swells and ache, the nebula of looking unfamiliar film, headache due to pathogenic wind-heat.
5, Radix Sophorae Flavescentis: be the dry bark of rutaceae wampee or Cortex Phellodendri.
Nature and flavor: hardship, cold.
Performance characteristics: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, and hectic fever due to YIN-deficiency is heat always, night sweat, seminal emission, eczema pruritus.
6, the Rhizoma Anemarrhenae: be the mother's of liliaceous plant dry rhizome.
Nature and flavor: hardship, sweet, cold.
Performance characteristics: clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
7, Rhizoma Curcumae: monocotyledon Zingiberaceae, or the dry rhizome of RADIX CURCUMAE.
Nature and flavor: suffering, hardship, temperature.
Performance characteristics: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
8, Borneolum Syntheticum: be water white transparency or the crisp crystallization of white translucent lamellar.
Nature and flavor: hot, bitter, be slightly cold.
Performance characteristics: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be used for the calentura coma, convulsion is fainted, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Select the Radix Et Rhizoma Rhei heat-clearing and toxic substances removing among the side of the present invention for use, the monarch drug in the removing blood stasis collateral dredging side of being is aided with Flos Lonicerae, heat-clearing and toxic substances removing, wind-heat dissipating, Flos Chrysanthemi, Flos Eriocauli dispelling wind and heat pathogens, suppressing the hyperactive liver makes eye bright, power with enhancing monarch drug heat-clearing and toxic substances removing is ministerial drug altogether, Radix Sophorae Flavescentis heat clearing and damp drying, Rhizoma Anemarrhenae clearing away heat-fire, promote the production of body fluid and moisturize, the pain relieving of Rhizoma Curcumae circulation of qi promoting removing blood stasis is an adjuvant drug, and it is diffusing strongly fragrant that Borneolum Syntheticum removes heat clearing away, outside the anti-inflammatory analgetic, and fragrance is walked to scurry, the through disease of all medicines messenger drug of doing in the current Zhu Jinger side of drawing, more than all medicines tie in, gather heat-clearing and toxic substances removing altogether, promoting blood circulation to remove obstruction in the collateral, the health-care effect of liver heat removing and eyesight improving.
The present invention identifies to this medicine that through the disease prevention and control center, Shaanxi Province the result shows:
One, character, weight differential, volatile oil are differentiated:
Assay:
1. shape: sepia patch.
2. weight differential :+7.4%.
3. volatile oil is differentiated: be positive reaction.
Two, microbiological indicator
Assay:
| Lot number | 20050620 |
| Total number of bacterial colonies (cfu/g) | ＜10 |
| Mold colony sum (cfu/g) | ＜10 |
| Coliform | Do not detect |
| Bacillus pyocyaneus | Do not detect |
| Staphylococcus aureus | Do not detect |
Estimate: according to DB61-266-1998 " health product hygienic requirements ", institute's sample product are up to specification.
Three, rat acute percutaneous toxicity test
1, tried thing: the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover ".
2, experimental animal: provide 20 of SD rat by the Traditional Chinese Medicine Research Institute, Shanxi Province Experimental Animal Center, male and female half and half, body weight 180-220g, one-level animal (the moving word of doctor 08-25 number), feed resource is the same.
3, animal housing's environment: temperature: 25-27 ℃, relative humidity: 45%-55%.The Animal House quality certification number: the moving word of doctor 08-37 number.
4, test method: tested preceding 24 hours, in back part of animal spinal column both sides unhairing, the unhairing scope is about 10% of body surface area, dosage (coating amount 0.5g/100g.bw) by 5000mg/kg.bw applies and fixes examination Mus unhairing position, after 24 hours, warm water is removed the residual thing that tried, and observes continuously 7 days.
5, result of the test: do not see examination Mus whole body ANOMALOUS VARIATIONS in the observation period, do not see the phenomena of mortality yet, be coated with tried the thing part not show swell, fester, reaction such as inflammation necrosis, the results are shown in Table.
| The animal sex | Dosage (mg/ kg.bw) | Examination Mus number (only) | Dead animal number (only) | Mortality rate (%) |
| Female Mus | 5000 | 10 | 0 | 0 |
| Male Mus | 5000 | 10 | 0 | 0 |
Last table expression, the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " is to female rat percutaneous LD
50All greater than 5000mg/kg.bw.
6, evaluation of result: according to acute dermal toxicity grade scale among the DB61-267-1998 " health product peace sage's property toxicological evaluation program and shuttle proved recipe method ", the nontoxic level in the present invention " a chrysanthemum man of virtue and ability rectifys and looks a health cover " true border of rat toxicity percutaneous toxicity.
Four, repeatedly skin irritation test
1, tried thing: the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " is the preparation ointment.
2, experimental animal: provide by Xi'an Jiaotong University Medical College's Experimental Animal Center, 4 of Japanese white big ear rabbits, male and female half and half, body weight 2.5-3.2kg, one-level animal (the moving word of doctor 08-018 number), feed resource is the same.
3, animal housing's environment: temperature: 25-27 ℃, relative humidity 45%-55%.The Animal House quality certification number: the moving word of doctor 08-37 number.
4, test method: tested preceding 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3cm * 6cm of unhairing scope.Get and tried 0.5g/ rabbit of thing soak and spread upon on the side skin, opposite side all is coated with distilled water and compares. smears every day once, smeared continuously 14 days, observe dermoreaction every day, press skin irritation reaction appraisal result among the DB61-267-1998 " the health product safety toxicological evaluation program and the method for inspection ", fill in a form, after the off-test, drill through spreader portion position skin with corneal ring and carry out pathological anatomy inspection and scoring.
5, result of the test: see Table.
The present invention's " chrysanthemum man of virtue and ability paste for treating prostate " is to rabbit skin irritation result of the test repeatedly
6, evaluation of result:
The present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " is to rabbit skin irritant reaction observed result, and average every day, every animal integral mean value was 0; Smearing position dermal pathology histological examination scoring is 0.According to skin irritation strength grading standard repeatedly among the DB61-267-1998 " the health product safety toxicological evaluation program and the method for inspection ", the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " belongs to nonirritant to skin irritation intensity.
Five, skin anaphylactic test
1, tried thing: the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " is the preparation ointment.Positive control: 2,4-dinitro-chloro-benzene (DNCB), produce in Xing Jin chemical plant, Beijing, lot number 20020522.
2, laboratory animal: provide 30 of Cavia porcelluss, male and female half and half, body weight 250-300g, one-level animal by Xi'an Jiaotong University Medical College experimental animal center.Feed resource is the same.Give and to be tried preceding 24 hours of thing guinea pig back left of spine/right side hair is removed the about 3cmX3cm of unhairing scope.
3, animal housing's environment: temperature: 22-25 ℃, relative humidity: 45%-55%.The Animal House quality certification number: the moving word of doctor 08-37 number.
4, test method: will test Cavia porcellus and be divided into three groups at random by body weight, sex, 10 every group, female, hero half and half is respectively and is tried thing group, negative control group and positive controls.
Sensitization contact; Get and tried thing 0.2g, evenly be coated in depilation district, back, animal left side, continue 6 hours.The 7th day and fortnight are used with quadrat method and are repeated once, and positive controls is coated with 1%DNCB, and negative control group does not deal with.
Excite contact: to fortnight after being tried thing, will be tried thing 0.2g in last, and evenly be coated on depilation district, guinea pig back right side, and remove after 6 hours and tried thing, and observe the anaphylaxis situation at once, and observe again in 1,24,48,72 hour then.Positive controls is coated with 0.1%DNCB, and negative control group does not deal with.Observational technique is with being tried the thing group.The result estimates by relevant sensitization of skin standard among the DB61-267-1998 " the health product safety toxicological evaluation program and the method for inspection ".
| Group | Number of animals | The sensitization number | The sensitization rate | Intensity |
| Tried thing | 10 | 0 | 0 | No sensitization |
| Negative control | 10 | 0 | 0 | No sensitization |
| Positive control | 10 | 10 | 100 | The extreme sensitization |
Observed result: being tried thing group sensitization rate is 0.
5, evaluation of result: according to relevant sensitization of skin standard among the DB61-267-1998 " the health product safety toxicological evaluation program and the method for inspection ", the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " belongs to no sensitization.
Six, antiinflammatory test, antipruritic test, microcirculation test
1, assay:
(1), antiinflammatory test: the scorching measurement result demonstration of the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " mouse ear caused by dimethylbenzene xylene is subjected to examination group mouse ear inflammation swelling degree to be significantly less than the blank group, and difference has highly significant (P＜0.01).
(2), antipruritic test: the antipruritic test determination result of the present invention " a chrysanthemum man of virtue and ability rectify look a health cover " Cavia porcellus shows that being tried thing group Cavia porcellus causes and itch apparently higher than matched group, and difference has highly significant (P＜0.01).
(3), microcirculation test: mice microcirculation test determination result demonstration is obviously increased than the blank group by the fine motion of examination group, vein bore and blood capillary number average the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover ", and difference all has highly significant (P＜0.01).
2, estimate: the present invention's " a chrysanthemum man of virtue and ability rectifys and looks a health cover " has the effect of antiinflammatory, antipruritic and microcirculation improvement.
Embodiment 1:
Chinese medicine of the present invention is made by following materials of weight proportions:
100 parts of 1500 parts of Flos Chrysanthemis of 1500 portions of Flos Loniceraes of Radix Et Rhizoma Rhei
500 parts of 1000 parts of Rhizoma Anemarrhenaes of 500 parts of Flos Eriocaulis of Radix Sophorae Flavescentis
10 parts of 100 parts of Borneolum Syntheticums of Rhizoma Curcumae.
Dosage form of the present invention is that the preparation method processing step of patch is as follows:
Flos Chrysanthemi, the Rhizoma Curcumae cold drying is pulverized, and sieving makes into fine powder, get the Mel heating again and refine into old honey, when treating that temperature is reduced to 50～80 ℃ of left and right sides, add above-mentioned fine powder and stir, mixing, it is standby to make sweet cream, Borneolum Syntheticum, ethyl hydroxybenzoate adds ethanol and dissolves in right amount, collects the solution for standby Radix Et Rhizoma Rhei, Flos Lonicerae, Flos Eriocauli, Radix Sophorae Flavescentis, the Rhizoma Anemarrhenae add 5～10 times of water gagings and decoct twice, decoct and are respectively 0.5～3h, collecting decoction filters, filtrate decompression is concentrated into the extractum of 1.0～2.0 (60 ℃ of surveys), vaseline, lanoline heating melting is under continuous equidirectional stirring, slowly add above-mentioned extractum, continue to stir, mixing is when treating that temperature is reduced to 30～60 ℃ of left and right sides, add above-mentioned sweet cream and solution again, stir, mixing is made subsides.
Embodiment 2:
Chinese medicine of the present invention is made by following materials of weight proportions:
90 parts of 1490 parts of Flos Chrysanthemis of 1490 portions of Flos Loniceraes of Radix Et Rhizoma Rhei
490 parts of 900 parts of Rhizoma Anemarrhenaes of 490 parts of Flos Eriocaulis of Radix Sophorae Flavescentis
5 parts of 90 parts of Borneolum Syntheticums of Rhizoma Curcumae.
Dosage form of the present invention is that the preparation method processing step of patch is the same.
Embodiment 3:
Chinese medicine of the present invention is made by following materials of weight proportions:
110 parts of 1510 parts of Flos Chrysanthemis of 1510 portions of Flos Loniceraes of Radix Et Rhizoma Rhei
510 parts of 1010 parts of Rhizoma Anemarrhenaes of 510 parts of Flos Eriocaulis of Radix Sophorae Flavescentis
15 parts of 110 parts of Borneolum Syntheticums of Rhizoma Curcumae.
Dosage form of the present invention is that the preparation method processing step of patch is the same.
Claims (3)
1. ocular disease health product with antiinflammatory, antipruritic and microcirculation improvement, it is characterized in that: the raw materials of effective components of described health product is formed and weight proportion is:
Radix Et Rhizoma Rhei 1490-1510 part Flos Lonicerae 1490-1510 part Flos Chrysanthemi 90-110 part
Radix Sophorae Flavescentis 490-510 part Flos Eriocauli 900-1010 part Rhizoma Anemarrhenae 490-510 part
Rhizoma Curcumae 90-110 part Borneolum Syntheticum 5-15 part;
The dosage form of described health product is a patch; Described dosage form is that the preparation method of patch is:
Flos Chrysanthemi, the Rhizoma Curcumae cold drying is pulverized, and sieving makes into fine powder, get the Mel heating again and refine into old honey, when treating that temperature is reduced to 50～80 ℃, add above-mentioned fine powder and stir, mixing, it is standby to make sweet cream, Borneolum Syntheticum, ethyl hydroxybenzoate adds ethanol and dissolves in right amount, collects solution for standby, Radix Et Rhizoma Rhei, Flos Lonicerae, Flos Eriocauli, Radix Sophorae Flavescentis, the Rhizoma Anemarrhenae adds 5～10 times of water gagings and decocts twice, decoction is respectively 0.5～3h, and collecting decoction filters, and the relative density when filtrate decompression is concentrated into 60 ℃ is 1.0～2.0 extractum, vaseline, lanoline heating melting, under continuous equidirectional stirring, slowly add above-mentioned extractum, continue to stir, mixing, when treating that temperature is reduced to 30～60 ℃, add above-mentioned sweet cream and solution again, stir, mixing is made subsides.
2. a kind of ocular disease health product according to claim 1 with antiinflammatory, antipruritic and microcirculation improvement, it is characterized in that: the raw materials of effective components of described health product is formed and weight proportion is:
100 parts of 1500 parts of Flos Chrysanthemis of 1500 portions of Flos Loniceraes of Radix Et Rhizoma Rhei
500 parts of 1000 parts of Rhizoma Anemarrhenaes of 500 parts of Flos Eriocaulis of Radix Sophorae Flavescentis
10 parts of 100 parts of Borneolum Syntheticums of Rhizoma Curcumae.
3. a kind of ocular disease health product with antiinflammatory, antipruritic and microcirculation improvement according to claim 2 is characterized in that: described dosage form is that the adjuvant of patch is formed and weight proportion is:
100 parts of 100 parts of Mel of 1600 parts of lanolines of vaseline
3 parts of ethyl hydroxybenzoates.
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|---|---|---|---|
| CN2009100223371A CN101601842B (en) | 2009-05-05 | 2009-05-05 | Health care product for relieving and preventing ocular diseases and preparation method thereof |
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| CN101601842B true CN101601842B (en) | 2011-12-14 |
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| CN106109751A (en) * | 2016-07-21 | 2016-11-16 | 广州道佑健康管理有限公司 | Improve vision improving eyesight cream side |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205209A (en) * | 1997-07-14 | 1999-01-20 | 沈阳王朝医药保健品公司 | Eye clearing Chinese medicine placing in palpebra inferior and its prepn. method |
| CN1698578A (en) * | 2004-05-17 | 2005-11-23 | 孙凤楼 | Eye plaster formula and preparation technique thereof |
| CN101264131A (en) * | 2008-04-30 | 2008-09-17 | 通化力神保健品有限公司 | Chinese medicine extracting liquid eye plaster and preparation thereof |
-
2009
- 2009-05-05 CN CN2009100223371A patent/CN101601842B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205209A (en) * | 1997-07-14 | 1999-01-20 | 沈阳王朝医药保健品公司 | Eye clearing Chinese medicine placing in palpebra inferior and its prepn. method |
| CN1698578A (en) * | 2004-05-17 | 2005-11-23 | 孙凤楼 | Eye plaster formula and preparation technique thereof |
| CN101264131A (en) * | 2008-04-30 | 2008-09-17 | 通化力神保健品有限公司 | Chinese medicine extracting liquid eye plaster and preparation thereof |
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