CN101600461B - 通过干细胞营养物进行的器官的形成和复壮以及酒精损伤的器官的再生 - Google Patents
通过干细胞营养物进行的器官的形成和复壮以及酒精损伤的器官的再生 Download PDFInfo
- Publication number
- CN101600461B CN101600461B CN200780051025.2A CN200780051025A CN101600461B CN 101600461 B CN101600461 B CN 101600461B CN 200780051025 A CN200780051025 A CN 200780051025A CN 101600461 B CN101600461 B CN 101600461B
- Authority
- CN
- China
- Prior art keywords
- alcohol
- cholesterol
- shh
- embryos
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D121/00—Coating compositions based on unspecified rubbers
- C09D121/02—Latex
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L61/00—Compositions of condensation polymers of aldehydes or ketones; Compositions of derivatives of such polymers
- C08L61/20—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen
- C08L61/26—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes with heterocyclic compounds
- C08L61/28—Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes with heterocyclic compounds with melamine
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D109/00—Coating compositions based on homopolymers or copolymers of conjugated diene hydrocarbons
- C09D109/06—Copolymers with styrene
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09D133/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09D133/10—Homopolymers or copolymers of methacrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/10—Homopolymers or copolymers of methacrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/18—Homopolymers or copolymers of nitriles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L35/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L35/06—Copolymers with vinyl aromatic monomers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L9/00—Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L9/00—Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
- C08L9/06—Copolymers with styrene
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Paints Or Removers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410024846.9A CN104391125B (zh) | 2006-12-08 | 2007-12-10 | 通过干细胞营养物进行的器官的形成和复壮以及酒精损伤的器官的再生 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87382606P | 2006-12-08 | 2006-12-08 | |
| US60/873,826 | 2006-12-08 | ||
| US90194507P | 2007-02-14 | 2007-02-14 | |
| US60/901,945 | 2007-02-14 | ||
| US92392707P | 2007-04-17 | 2007-04-17 | |
| US60/923,927 | 2007-04-17 | ||
| PCT/US2007/025181 WO2008073352A1 (en) | 2006-12-08 | 2007-12-10 | Formation and rejuvenation of organs and alcohol damaged organ regeneration through stem cell nutrients |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410024846.9A Division CN104391125B (zh) | 2006-12-08 | 2007-12-10 | 通过干细胞营养物进行的器官的形成和复壮以及酒精损伤的器官的再生 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101600461A CN101600461A (zh) | 2009-12-09 |
| CN101600461B true CN101600461B (zh) | 2014-03-05 |
Family
ID=39272877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780051025.2A Expired - Fee Related CN101600461B (zh) | 2006-12-08 | 2007-12-10 | 通过干细胞营养物进行的器官的形成和复壮以及酒精损伤的器官的再生 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090326138A1 (enExample) |
| EP (1) | EP2089484B1 (enExample) |
| CN (1) | CN101600461B (enExample) |
| AT (1) | ATE496976T1 (enExample) |
| DE (1) | DE602007012293D1 (enExample) |
| WO (1) | WO2008073273A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| CN106366742A (zh) * | 2016-08-30 | 2017-02-01 | 杭州菲尔卡斯节能科技有限公司 | 一种水性多彩仿石涂料及其制备方法 |
| KR102546194B1 (ko) | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| JP7506657B2 (ja) | 2018-07-26 | 2024-06-26 | チルドレンズ ホスピタル メディカル センター | 肝胆膵組織およびその作製方法 |
| US12428622B2 (en) | 2018-09-12 | 2025-09-30 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| JP7610533B2 (ja) | 2019-05-31 | 2025-01-08 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞の生成および拡大方法 |
| CN111040990A (zh) * | 2019-12-13 | 2020-04-21 | 深圳先进技术研究院 | 一种斑马鱼胚胎全氟化合物内暴露模型的构建方法及应用 |
| CN116585327A (zh) * | 2023-03-23 | 2023-08-15 | 中国药科大学 | 环巴胺或其衍生物在制备治疗和/或预防非酒精性脂肪肝疾病中的应用 |
| CN117783501B (zh) * | 2024-02-26 | 2024-05-10 | 四川大学华西第二医院 | 辛酸钠在注意缺陷与多动障碍中的应用及产品 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2739137A (en) * | 1952-02-20 | 1956-03-20 | Eastman Kodak Co | Method for making polymeric hydrosols |
| US3922244A (en) * | 1974-03-15 | 1975-11-25 | Mobil Oil Corp | Thermosetting water-based coatings |
| GB1513374A (en) * | 1974-07-16 | 1978-06-07 | Canadian Ind | Aqueous thermosettable coating compositions |
| US5166254A (en) * | 1990-12-03 | 1992-11-24 | E. I. Du Pont De Nemours And Company | Waterbased coating composition of methylol (meth)acrylamide acrylic polymer, acrylic hydrosol and melamine crosslinking agent |
| JPH0890508A (ja) * | 1994-09-29 | 1996-04-09 | Mitsui Toatsu Chem Inc | 突板化粧板の製造方法 |
-
2007
- 2007-12-05 US US12/518,126 patent/US20090326138A1/en not_active Abandoned
- 2007-12-05 DE DE602007012293T patent/DE602007012293D1/de active Active
- 2007-12-05 AT AT07862600T patent/ATE496976T1/de not_active IP Right Cessation
- 2007-12-05 WO PCT/US2007/025008 patent/WO2008073273A2/en not_active Ceased
- 2007-12-05 EP EP07862600A patent/EP2089484B1/en not_active Not-in-force
- 2007-12-10 CN CN200780051025.2A patent/CN101600461B/zh not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Joseph Bilotta et al.Ethanol exposure alters zebrafish development: A novel model of fetal alcohol syndrome.《Neurotoxicology and Teratology》.2004,第26卷第737-743页. * |
| Marina Guizzetti et al.Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: an hypothesis.《Medical Hypotheses》.2005,第64卷第563-567页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2089484B1 (en) | 2011-01-26 |
| CN101600461A (zh) | 2009-12-09 |
| US20090326138A1 (en) | 2009-12-31 |
| DE602007012293D1 (enExample) | 2011-03-10 |
| EP2089484A2 (en) | 2009-08-19 |
| WO2008073273A2 (en) | 2008-06-19 |
| ATE496976T1 (de) | 2011-02-15 |
| WO2008073273A3 (en) | 2009-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101600461B (zh) | 通过干细胞营养物进行的器官的形成和复壮以及酒精损伤的器官的再生 | |
| WO2008073352A1 (en) | Formation and rejuvenation of organs and alcohol damaged organ regeneration through stem cell nutrients | |
| Li et al. | Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling | |
| Bernard-Marissal et al. | Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration | |
| Harada et al. | The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma | |
| Sanchez-Ortiz et al. | TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry | |
| Haider et al. | The transcription factor Nr2e3 functions in retinal progenitors to suppress cone cell generation | |
| Alsina et al. | Lrig1 is a cell‐intrinsic modulator of hippocampal dendrite complexity and BDNF signaling | |
| Boucher et al. | Heterozygous neuregulin 1 mice display greater baseline and Δ9-tetrahydrocannabinol-induced c-Fos expression | |
| WO2009135091A1 (en) | Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions | |
| Conti et al. | Caffeine protects against retinal inflammation | |
| Fischer et al. | Impairment of membrane repolarization accompanies axon transport deficits in glaucoma | |
| Hu et al. | Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits | |
| Chen et al. | Astragaloside suppresses tumor necrosis factor receptor‐associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane | |
| Ramos-Brossier et al. | Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability | |
| Garcia et al. | Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension | |
| Xiao et al. | Switching of N-methyl-D-aspartate (NMDA) receptor-favorite intracellular signal pathways from ERK1/2 protein to p38 mitogen-activated protein kinase leads to developmental changes in NMDA neurotoxicity | |
| Sakamoto et al. | Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina | |
| US20250032425A1 (en) | First in class use of estrogen receptor beta agonists in treating angelman syndrome and relevant autism spectrum disorders | |
| Murphy et al. | Endothelin-1–Induced Proliferation Is Reduced and Ca2+ Signaling Is Enhanced in Endothelin B–Deficient Optic Nerve Head Astrocytes | |
| Sutherland et al. | The Age-Dependent Decline in Neuron Growth Potential in the CNS is Associated with an Age-Related Dysfunction of Neuronal Mitochondria | |
| Tan | The role of Fragile X Mental Retardation Protein in Parkinson’s disease | |
| Yang | The role of basal autophagy in oligodendrocyte development | |
| Tucker | The function of mTORC1 in craniofacial morphogenesis and ethanol teratogenesis | |
| WO2025113506A1 (zh) | 诊断和治疗阿尔茨海默病的医药制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140305 |