CN101590013A - A kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to - Google Patents
A kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to Download PDFInfo
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- CN101590013A CN101590013A CNA2008100533725A CN200810053372A CN101590013A CN 101590013 A CN101590013 A CN 101590013A CN A2008100533725 A CNA2008100533725 A CN A2008100533725A CN 200810053372 A CN200810053372 A CN 200810053372A CN 101590013 A CN101590013 A CN 101590013A
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- nyctereutes procyonoides
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Abstract
A kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to relates to a kind of compound injection liquid product, particularly relates to a kind of anthelmintic compound injection finished product of Vulpes Nyctereutes procyonoides ermine medicinal liquid that is used for.The described finished product medicinal liquid of technical solution of the present invention is a major ingredient for 3～5 parts with 0.5～1 part of commercially available ivermectin, albendazole, mixes formation for 100 parts with the pure product glycerol formal of commercially available pharmaceutic adjuvant level.Finished product medicinal liquid of the present invention has made full use of the anthelmintic of ivermectin inside and outside, anthelmintic pharmacological action in the albendazole body, the anthelmintic curative effect has been strengthened in the compound use of two kinds of compositions greatly, to nematicide, ascarid, pinworm, cestode, whipworm, ancylostome, excrement strongylid etc. in the body, vermins such as acarid, sarcoptic mite, fly larvae all there is anthelminthic effect preferably.Thereby can reduce the diarrhoea that Vulpes Nyctereutes procyonoides ermine is caused because of parasite greatly, improve the fur quality of Vulpes Nyctereutes procyonoides ermine, improve and culture income.
Description
Technical field
The present invention relates to a kind of compound injection liquid product, particularly relate to a kind of anthelmintic compound injection liquid product of Vulpes Nyctereutes procyonoides ermine that is used for.
Background technology
The breed of Vulpes Nyctereutes procyonoides ermine is its main feature with easy raising, low cost and high benefit, its fur market value is applied in continuous expansion, become the genuine leader of animal farming industry, injected vigor, propping up the half the sky of Chinese aquaculture for the aquaculture of China.
Diarrhoea is a kind of to the serious disease of Vulpes Nyctereutes procyonoides ermine harm, and M ﹠ M is high.Show that according to certain plant statistics in the past few years dead mink accounts for 75%～81% of dead sum because of suffering from diarrhoea.Parasitic disease is to cause one of Vulpes Nyctereutes procyonoides ermine diarrheal principal element, and its parasitic disease mainly contains coccidiosis, trichinella, ascarid, toxoplasma etc., can cause the disorder of mink function of intestinal canal, the intestinal mucosa inflammation, thus cause diarrhoea.It is pale that symptom is mainly a conjunctiva, and anemia is slowly become thin.From feces, can find worm's ovum.Primary disease is with dysentery, and body temperature is normal or high slightly, and abdominal part is tired to contract, the oral cavity frowziness, and tongue fur turns white, and vomiting and thirsty desire are often arranged.Can reduce the diarrhoea that causes because of parasite greatly by the inside and outside anthelmintic, improve the fur quality, improve and culture income.But because the raw material of anthelmintic is very limited at present, the anthelmintic that people generally adopt pig, cattle and sheep class larger animal to use to the anthelmintic of economic class animals such as Vulpes Nyctereutes procyonoides ermine does not have special method and medicine.Cattle and sheep pig anthelmintic injection is an adjuvant with glycerol, dimethyl formyl etc. mainly, and is very sensitive to this class organic solvent because the volume of economic class animal is little, in light weight, when stating the anthelmintic injection in the use, goes up all different with larger animal with metering on dosage form.Therefore, be applicable to that with such anthelmintic injection economic class animal tends to because the gap of metering is big, cause the poisoning of economic class animal easily.
The technology contents of invention
The objective of the invention is by a kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to is provided, can effectively expel the endoparasite and ectoparasite of Vulpes Nyctereutes procyonoides ermine, the endoparasite and ectoparasite that the significantly reduces Vulpes Nyctereutes procyonoides ermine rate of catching an illness, and then solved the problem that exists in the above-mentioned background technology.
The described finished product medicinal liquid of technical solution of the present invention is a major ingredient for 3～5 parts with 0.5～1 part of commercially available ivermectin, albendazole, mixes formation for 100 parts with the pure product glycerol formal of commercially available pharmaceutic adjuvant level.
Described umber is meant that when solid unit of weight is g the volume unit of liquid is ml; When solid unit of weight was kg, the volume unit of liquid was 1, and the rest may be inferred.
In above-mentioned every composition, preferable component ratio is that 1 part of ivermectin, albendazole are major ingredient, 100 parts of glycerol formals for 3 parts.
In every composition of finished product medicinal liquid of the present invention, its anthelmintic mechanism of major ingredient ivermectin is to increase the release of the inhibitory transmitter r-aminobutyric acid of polypide, and the Cl-passage of opening glutamic acid control, strengthen the permeability of neurolemma to Cl-, thereby the transmission of block nerves signal, final neural paralysis makes muscle cell lose contractility, and causes polypide death.Therefore ivermectin is novel wide spectrum, efficient, low toxicity antibiotics parasiticide class medicine, and endoparasite and ectoparasite especially nematicide and arthropod are all had anthelmintic action preferably.Albendazole suppresses the absorption of parasite to glucose after metabolism is sulfoxide class or sulfone class in vivo, causes the polypide glycogen depletion, or suppresses the fumaric reductase system, hinders the generation of ATP, and parasite can't be survived and breed.Therefore the finished product medicinal liquid of the present invention broad-spectrum de-worming medicine that is a high-efficiency low-toxicity.Clinically can be used for ascarifuge, pinworm, cestode, whipworm, ancylostome, excrement strongylid etc.
Finished product medicinal liquid of the present invention has made full use of the anthelmintic of ivermectin inside and outside, anthelmintic pharmacological action in the albendazole body, and the anthelmintic curative effect has been strengthened in the compound use of two kinds of compositions greatly.Ivermectin, albendazole are used for anthelmintic in the body jointly, nematicide, ascarid, pinworm, cestode, whipworm, ancylostome, excrement strongylid etc. in the body are had good anthelminthic effect, and ivermectin all has anthelminthic effect preferably to vermins such as acarid, sarcoptic mite, fly larvae simultaneously.In use can be directly according to dosage require direct injection in economic class animal both can, can not produce because the animal intoxicating phenomenon that Dose Problem causes.
During making, after glycerol formal is heated to 60 ℃, add commercially available ivermectin and albendazole successively according to above-mentioned ratio, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
This finished product medicinal liquid is an injection, and shading, sealing are preserved.With in the finished product medicinal liquid inhalation syringe, carry out intramuscular injection during use by ivermectin content 0.1mg/Kg the weight of animals in the finished product medicinal liquid.
Major ingredient ivermectin of the present invention is novel wide spectrum, efficient, low toxicity antibiotics parasiticide class medicine, and endoparasite and ectoparasite especially nematicide and arthropod are all had anthelmintic action preferably.Albendazole is the broad-spectrum de-worming medicine of a high-efficiency low-toxicity.Clinically can be used for ascarifuge, pinworm, cestode, whipworm, ancylostome, excrement strongylid etc.The compound preparation of two kinds of medicines can be driven away Vulpes Nyctereutes procyonoides ermine endoparasite and ectoparasite fully, and clinical efficacy is remarkable.
The clinical trial example:
In vivo test project standard in the clinical trial of anthelmintic medicament in " the new veterinary drug and the veterinary drug novel formulation management method " of in JIUYUE, 1989 promulgation of the execution Ministry of Agriculture. 30 of ermine cultivation base, Tangshan City ermines, be divided into 2 groups according to the completely random method, one group is used the finished product medicinal liquid of making according to the embodiment of the invention 6, as test group; Another group is organized in contrast with the ivermectin injection of folk prescription.
1.1 feedstuff mode: artificial cultivation.
1.2 dosage scheme: test group is pressed ivermectin content 0.1mg/kg the weight of animals in the finished product medicinal liquid (1 amount) administration.Positive controls is according to ivermectin content 0.1mg/kg the weight of animals in the ivermectin injection of folk prescription (1 amount) administration.
1.3 inspection index:
(1) nematicide (esophageal orifice nematicide, Bunostomum trigonoce phalum);
(2) worm's ovum is supported before rate (%)=anthelmintic average worm's ovum number/g * 100% after average worm's ovum number/g-anthelmintic
(3) after the continuous review medication 15 days with interior anthelminthic effect;
1.4 worm's ovum inspection technique: get fresh excreta 10g.Add the saturated sodium-chloride fluid injection, 100ml mixes, and by 60 order copper sieve, filters in the inflow beaker, leaves standstill 30min, the worm's ovum come-up; With diameter is the iron wire loop of 8cm, and parallel contact with liquid level is glued and got surperficial liquid film, shakes off with section slide and checks a worm's ovum number.
2, result of the test
The test of pesticide effectiveness of control ermine nematicide the results are shown in following table:
Statistical test result shows, test group and matched group be average worm's ovum slip difference extremely significantly (P＜0.01) after medication.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
After glycerol formal is heated to 60 ℃, add ivermectin 0.5g and albendazole 3g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was promptly made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
Embodiment 2
After glycerol formal 100ml is heated to 60 ℃, add ivermectin 0.5g and albendazole 5g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding in the 2ml ampoule, in 100 ℃ of flowing steam sterilizations 30 minutes system the finished product medicinal liquid.
Embodiment 3
After glycerol formal 100ml is heated to 60 ℃, add ivermectin 0.5g and albendazole 3.5g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was promptly made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
Embodiment 4
After glycerol formal 100ml is heated to 60 ℃, add ivermectin 0.7g and albendazole 4g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was promptly made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
Embodiment 5
After glycerol formal 100ml is heated to 60 ℃, add ivermectin 0.8g and albendazole 3g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was promptly made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
Embodiment 6
After glycerol formal 100ml is heated to 60 ℃, add ivermectin 1g and albendazole 3g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was promptly made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
Embodiment 7
After glycerol formal 100ml is heated to 60 ℃, add ivermectin 0.1g and albendazole 4g successively, being stirred to dissolving with the agitator of routine with 38 rev/mins both can, then with the filtering with microporous membrane of 0.8ug, promptly can be made into colourless, transparent solution, embedding was promptly made the finished product medicinal liquid in 30 minutes at 100 ℃ of flowing steam sterilizations in the 2ml ampoule.
Claims (3)
1. one kind is applicable to the anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine, the finished product medicinal liquid that it is characterized in that described preparation is a major ingredient for 3～5 parts with 0.5～1 part of commercially available ivermectin, albendazole, mixes formation for 100 parts with the pure product glycerol formal of commercially available pharmaceutic adjuvant level; Described umber is meant that when solid unit of weight is g the volume unit of liquid is ml; When solid unit of weight was kg, the volume unit of liquid was 1, and the rest may be inferred.
2. a kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to according to claim 1, the preferable component ratio of finished product medicinal liquid that it is characterized in that described preparation are that 1 part of ivermectin, albendazole are major ingredient, 100 parts of glycerol formals for 3 parts.
3. a kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to according to claim 1, the finished product medicinal liquid that it is characterized in that described preparation is colourless, transparency liquid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100533725A CN101590013A (en) | 2008-05-30 | 2008-05-30 | A kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to |
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| CNA2008100533725A CN101590013A (en) | 2008-05-30 | 2008-05-30 | A kind of anthelmintic compound injection liquid formulation of Vulpes Nyctereutes procyonoides ermine that is applicable to |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105409986A (en) * | 2015-11-19 | 2016-03-23 | 安徽农业大学 | Nematicidal compound containing fluopyram and albendazole and application thereof |
| CN109431983A (en) * | 2018-11-30 | 2019-03-08 | 合肥中龙神力动物药业有限公司 | A kind of compound ivermectin injection and preparation method thereof |
-
2008
- 2008-05-30 CN CNA2008100533725A patent/CN101590013A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105409986A (en) * | 2015-11-19 | 2016-03-23 | 安徽农业大学 | Nematicidal compound containing fluopyram and albendazole and application thereof |
| CN109431983A (en) * | 2018-11-30 | 2019-03-08 | 合肥中龙神力动物药业有限公司 | A kind of compound ivermectin injection and preparation method thereof |
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Open date: 20091202 |