CN104606195B - A kind of compound herba fibraureae recisea injection and preparation method thereof - Google Patents
A kind of compound herba fibraureae recisea injection and preparation method thereof Download PDFInfo
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- CN104606195B CN104606195B CN201510036623.9A CN201510036623A CN104606195B CN 104606195 B CN104606195 B CN 104606195B CN 201510036623 A CN201510036623 A CN 201510036623A CN 104606195 B CN104606195 B CN 104606195B
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Abstract
A kind of compound herba fibraureae recisea injection, it is characterised in that every 1000ml compound herba fibraureae recisea injection is water for injection containing fibrauretin 10～50g, norfloxacin nicotinate 50～100g, compounded organic solvent 100 300g, surfactant 1 5g, antioxidant 1g 10g, surplus.The invention have the advantage that (1) constant product quality, especially within 2 year storage period, product characteristics, content, etc. other detections still in prescribed limit.(2) product can industrialized mass, cost is relatively low: owing to batch is the biggest, which decreases the various losses in production process, substantially increases finished product rate；(3) product has introduced norfloxacin nicotinate, change the original folk prescription of existing Luteal function failure, Integrated TCM more effectively strengthens the antibacterial ability of medicine, plays treating both the principal and secondary aspects of a disease effect, so all meeting or exceeding same similar products Luteal function failure in product drug effect.
Description
Technical field
The present invention relates to a kind of veterinary drug preparation method, specifically a kind of compound herba fibraureae recisea injection and preparation method thereof.
Background technology
By escherichia coli, Salmonella, pasteurella multocida, enterotoxigenic escherichia coli (ETEC), Minireovirus,
Visible peristalsis visible intestinal peristalsis adenovirus, swine dysentery spirillum, Porcine epidemic diarrhea virus (PEDV) and transmissible gastro-enteritis virus (TGEV) etc. are former
Because causing piglet diarrhea to be a kind of typical multi-pathogenesis disease under intensive pig production working condition.Before and after from the Beginning of Winter to the beginning of spring
Happening over and over again, sickness rate is high, and the course of disease is 5 days～10 days.Sick Corii Sus domestica temperature is the most whole, and the cold nose of ear is cool, flows thin nasal discharge, abdominal swelling, fear of cold
Fear cold curling oneself up, poor appetite or useless without thermal image or grade fever, rush down day more than ten time absolutely, it is the dilutest to rush down excrement, presents progressive emaciation,
Rapid dehydration after having loose bowels 1 day and lose flesh.Sick pig because of lose control or secondary infection and dead, piglet mortality rate is more than 15%.If no
Treatment in time, it is easy to cause piglet dead, bring huge economic loss to pig farm and raiser.
The medicine treating swine dysentery in the market has monomer, also has compound recipe.Its antibacterial range is narrower, therapeutic domain
Little, the half-life is short, owing to antibacterial produces drug resistance, reduces the therapeutic effect being used alone or does not has effect, thus causing secondary
Infect.Cause the generation of other diseases.
The present invention expands the antibacterial range of medicine, uses Integrated TCM, can effectively reduce drug residue, can increase again
Its curative effect strong.
Summary of the invention
It is an object of the invention to provide a kind of compound herba fibraureae recisea injection, it uses Chinese and western drugs to cooperate, and plays one
Plant the effect for the treatment of both the principal and secondary aspects of a disease.Strengthen the antibacterial range of medicine.The quality and the performance that make it are better than currently produced fibrauretin note
Penetrate liquid.Prevention and control diarrhea of pigs, improve swinery survival rate, promotes cultivation efficiency.
Another object of the present invention is to provide the preparation method of compound herba fibraureae recisea injection.
It is as follows that the present invention solves the technical scheme that above-mentioned technical problem taked.
Compound herba fibraureae recisea injection, is made up of following supplementary material medicine: every 1000ml compound herba fibraureae recisea injection is containing Caulis Fibraureae
Element 10～50g, norfloxacin nicotinate 50～100g, compounded organic solvent 100-300g, surfactant 1-5g, antioxidant 1g-
10g, surplus are water for injection.
Above-mentioned compounded organic solvent is ethanol, propylene glycol, dimethylformamide two kinds or two or more mixture.
Above-mentioned surfactant is span, tween, poloxamer.
Above-mentioned antioxidant is sodium sulfite, thiourea, sodium pyrosulfite, EDTA-2Na or its mixture.
Above-mentioned compound herba fibraureae recisea injection preparation is to sequentially include the following steps:
1. the water for injection taking total amount 30% is heated to 60-80 DEG C of addition fibrauretin, and stirring makes to be completely dissolved addition and is compounded with
Machine stirring solvent is uniform, becomes A liquid；
2. the water for injection taking total amount 30% is heated to 60-90 DEG C, adds norfloxacin nicotinate, and stirring makes to be completely dissolved into B
Liquid；
3. the water for injection addition antioxidant taking total amount 30% makes to be completely dissolved into C liquid；
4. C liquid joins A liquid, quickly stirs, then is slowly added to by B, stirring while adding, adds surfactant；
5. inject and be settled to 1000ml with water, embedding, 100 DEG C, 30 minutes flowing steam sterilizations.
Above-mentioned compound herba fibraureae recisea injection, its applicable object is: various domestic animals, other economic animals of poultry or house pet
Deng, its route of administration may is that intramuscular injection, subcutaneous injection.Its character is: yellow is to yellowish-brown clear liquid.
The invention have the advantage that (1) constant product quality, especially within 2 year storage period, product characteristics, content, etc. its
His detection is still in prescribed limit.(2) product can industrialized mass, cost is relatively low: owing to batch is the biggest, so
Reduce the various losses in production process, substantially increase finished product rate.Mass simultaneous reduces greatly the most to greatest extent
The other expenditure of production process；(3) product has introduced norfloxacin nicotinate, changes the original list of existing Luteal function failure
Side, Integrated TCM more effectively strengthens the antibacterial ability of medicine, plays treating both the principal and secondary aspects of a disease effect, so all reaching in product drug effect
Or exceed same similar products Luteal function failure.
Detailed description of the invention
Embodiment one: the water for injection 1. taking total amount 30% is heated to 60-80 DEG C of addition fibrauretin 10g, and stirring makes the most molten
Solve addition ethanol 100g, propylene glycol 50g to stir, become A liquid；
2. the water for injection taking total amount 30% is heated to 60-90 DEG C, adds norfloxacin nicotinate 50g, and stirring makes to be completely dissolved
Become B liquid；
3. water for injection addition sodium sulfite 1g, EDTA-2Na 0.3g taking total amount 30% makes to be completely dissolved into C liquid；
4. C liquid joins A liquid, quickly stirs, then is slowly added to by B, stirring while adding, adds sorbester p17 2g and stirs
Mix uniformly；
5. inject and be settled to 1000ml with water, embedding, 100 DEG C, 30 minutes flowing steam sterilizations.Obtain.
Embodiment two: the water for injection 1. taking total amount 30% is heated to 60-80 DEG C of addition fibrauretin 20g, and stirring makes the most molten
Solve addition ethanol 150g, dimethylformamide 10g to stir, become A liquid；
2. the water for injection taking total amount 30% is heated to 60-90 DEG C, adds norfloxacin nicotinate 55g, and stirring makes to be completely dissolved
Become B liquid；
3. the water for injection addition sodium pyrosulfite 2g taking total amount 30% makes to be completely dissolved into C liquid；
4. C liquid joins A liquid, quickly stirs, then is slowly added to by B, stirring while adding, adds tween 80 10g
Stir；
5. inject and be settled to 1000ml with water, embedding, 100 DEG C, 30 minutes flowing steam sterilizations.Obtain.
Embodiment three: the water for injection 1. taking total amount 30% is heated to 60-80 DEG C of addition fibrauretin 50g, and stirring makes the most molten
Solve addition dimethylformamide 150g, propylene glycol 150g to stir, become A liquid；
2. the water for injection taking total amount 30% is heated to 60-90 DEG C, adds norfloxacin nicotinate 100g, and stirring makes the most molten
Solution becomes B liquid；
3. the water for injection addition thiourea 5g taking total amount 30% makes to be completely dissolved into C liquid；
4. C liquid joins A liquid, quickly stirs, then is slowly added to by B, stirring while adding, adds poloxamer 5g and stirs
Mix uniformly；
5. inject and be settled to 1000ml with water, embedding, 100 DEG C, 30 minutes flowing steam sterilizations.Obtain.
Clinical test results
1, acute toxicity test: taking healthy mice 120, accurate weighed body weight, average weight is
16.1 g are uniformly divided into 6 groups by body weight size, respectively by per kilogram of body weight 0.05ml, 0.1ml, 0.2ml, 0.4ml,
0.6ml and 1ml intramuscular injection this product (containing fibrauretin 1%, norfloxacin nicotinate 5%, tests below same concentrations), sees after injection
Examining 3 days, there is death in none example of result, also finds no any untoward reaction.Result shows, this product is in per kilogram of body weight
It is safe for using under the normal using dosage of 0.2ml.
2, drug metabolism test: taking healthy test rabbit 20, the most weighed, average weight 2.6 is public
Jin, all by per kilogram of body weight intramuscular injection this product 0.2ml, adopts respectively at 0.5h, 2h, 4h, 8h, 16h, 24h, 48h
Test Cor Leporis blood, respectively fibrauretin, norfloxacin nicotinate in determination test rabbit blood, result remains to when 24h detect respectively often
Containing the fibrauretin of 1 ч g, norfloxacin nicotinate in ml blood, at 84 hours, blood remains to detect norfloxacin nicotinate.Result table
Bright, the drug effect of this product is more than 48h.
3, In Vitro Bacteriostasis contrast test: take Luteal function failure, respectively using escherichia coli as test organisms, Salmonella,
Being diluted by two kinds of medicines with doubling dilution, the minimal inhibitory concentration of result this product is the 1/4 of Luteal function failure.This
Result shows, shows that from laboratory test the curative effect of this product is better than niacin norfloxacin injection.
4, the clinical test of pesticide effectiveness: take natural occurrence Hakuri piglet 90, be randomly divided into three groups by body weight size, often organize 30
Head, average weight 29.3 kilograms, press per kilogram of body weight 0.2ml intramuscular injection this product and Luteal function failure respectively (containing fibrauretin
1%), result one time cure rate this product and note B component are not 93% and 77%, and secondary cure rate is respectively 97% and 83%.Result table
Bright, this product is better than folk prescription Luteal function failure in clinical drug effect.
5, the stability test of product: this product is stored under the ambient temperature of 40 DEG C, by observation and the detection of 6 months,
As a result, product colour change is little, and still in the scope of regulation, the relative amount of fibrauretin declines only 0.3%, and nicotinic acid promise fluorine is husky
The relative amount of star declines only 1.8%.Result shows, the shelf-life of this product should be and is not less than regulation effect duration 2 years.
Claims (2)
1. a compound herba fibraureae recisea injection, it is characterised in that every 1000ml compound herba fibraureae recisea injection containing fibrauretin 10～50g,
Norfloxacin nicotinate 50～100g, compounded organic solvent 100-300g, surfactant 1-5g, antioxidant 1g-10g, surplus are
Water for injection；Described compounded organic solvent is ethanol, propylene glycol, dimethylformamide two kinds or two or more mixing
Thing；Described surfactant is that span, tween, poloxamer select one of which；Described antioxidant is bisulfite
Sodium, thiourea, sodium pyrosulfite, EDTA-2Na or its mixture.
2. the preparation method of the animal compound Luteal function failure described in a claim 1, it is characterised in that preparation method is
Sequentially including the following steps: and 1. take the water for injection of total amount 30% and be heated to 60-80 DEG C and add fibrauretin, stirring makes to be completely dissolved and adds
Enter compounded organic solvent to stir, become A liquid；2. the water for injection taking total amount 30% is heated to 60-90 DEG C, adds nicotinic acid promise fluorine
Sha Xing, stirring makes to be completely dissolved into B liquid；3. the water for injection addition antioxidant taking total amount 30% makes to be completely dissolved into C liquid；4. C liquid
Join A liquid, quickly stir, then B is slowly added to, stirring while adding, add surfactant；5. it is fixed to inject with water
Hold to 1000ml, embedding, 100 DEG C, 30 minutes flowing steam sterilizations.
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| CN201510036623.9A CN104606195B (en) | 2015-01-26 | 2015-01-26 | A kind of compound herba fibraureae recisea injection and preparation method thereof |
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| CN201510036623.9A CN104606195B (en) | 2015-01-26 | 2015-01-26 | A kind of compound herba fibraureae recisea injection and preparation method thereof |
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| CN104606195B true CN104606195B (en) | 2017-01-04 |
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| CN104814965B (en) * | 2015-05-13 | 2017-12-19 | 哈尔滨千合动物药品制造有限公司 | Compound hydrochloric acid levofloxacin and preparation method thereof |
| CN105125483A (en) * | 2015-08-27 | 2015-12-09 | 浙江大飞龙动物保健品有限公司 | Florfenicol injection solution for veterinary use and preparation method of injection solution |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1602886A (en) * | 2003-09-29 | 2005-04-06 | 成都三明药物研究所 | Pharmaceutical compositions and its application |
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| CN1626079A (en) * | 2004-08-13 | 2005-06-15 | 贵阳云岩西创药物科技开发有限公司 | Fibrauretine injection preparation and preparing method |
| CN102600159A (en) * | 2012-03-09 | 2012-07-25 | 深圳松乐生物科技有限公司 | Composition comprising tetrandrine, tetrandrine-based ramification and fluoroquinolones and application of composition |
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