CN108635492A - A kind of Chinese medicine composition and the preparation method and application thereof of prevention Trichomonad of dove - Google Patents
A kind of Chinese medicine composition and the preparation method and application thereof of prevention Trichomonad of dove Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions of prevention Trichomonad of dove, by the Chinese medicinal composition of following parts by weight：48 parts of kuh-seng, 48 parts of Changshan, 48 parts of smilax, 26 parts of the Chinese bulbul, 26 parts of sweet wormwood, 13 parts of Radix Glycyrrhizae.The present invention has the characteristics that pure natural, noresidue as pure Chinese herbal medicine preparation, there is apparent preventive and therapeutic action to Trichomonad of dove, the use of metronidazole can be substituted, medicament residue problem caused by solving metronidazole, bacterial resistance sex chromosome mosaicism has significant public health meaning and environment protection significance.
Description
Technical field：
The present invention relates to compound Chinese medicinal preparation fields, and in particular to it is a kind of prevention Trichomonad of dove Chinese medicine composition and its
Preparation method and application.
Background technology：
It is one of pigeon for meat aquaculture common disease by the Trichomonad of dove caused by fowl trichmonad, sick dove, which is mainly shown as, to disappear
It is thin, it has loose bowels, the visible bottleneck throat mucous membrane of dissect has apparent button-type yellow deposit or ulcer surface.The disease can infect each age in days
Pigeon for meat, squab and virgin dove below 3 monthly ages are especially susceptible, and the death rate often causes serious warp up to 50% or more to pigeon for meat cultivation
Ji loss, it is estimated that cause the loss for supporting dove industry up to 200,000,000 yuan or more in year.
Metronidazole is always to prevent the choice drug of Trichomonad of dove, but metronidazole has certain toxicity, not only has
Lifelong carcinogenic mutagenesis, and the side effect of animal pancreatic inflammation and central lesion can be caused, if excessive make
With the reduction that can cause pigeon for meat production performance and drug resistance is generated, obviously occurs drug resistance in production in recent years, can induce
Public safety problem, separately since pigeon for meat distinctive parent's generation directly feeds squab, or so 20 day age of squab, which lists, becomes food
Raw material, the production cycle extremely short mode of production, metronidazole medicament residue cause potential hazard problem more to edible human body
Prominent, finding new alternative medicine becomes inevitable choice.
Invention content：
The object of the present invention is to provide a kind of Chinese medicine compositions and the preparation method and application thereof of prevention Trichomonad of dove, should
Composition has the characteristics that pure natural, noresidue as pure Chinese herbal medicine preparation, has to Trichomonad of dove and significantly prevents and control
Treatment acts on, medicament residue problem, bacterial resistance sex chromosome mosaicism caused by solving metronidazole.
The present invention is achieved by the following technical programs：
A kind of Chinese medicine composition of prevention Trichomonad of dove, by the Chinese medicinal composition of following parts by weight：4-8 parts of kuh-seng, Changshan
4-8 parts, 4-8 parts of smilax, 2-6 parts of the Chinese bulbul, 2-6 parts of sweet wormwood, 1-3 parts of Radix Glycyrrhizae.
Preferably, kuh-seng 5-7 parts, 4-6 parts of Changshan, 4-6 parts of smilax, 2-4 parts of the Chinese bulbul, 2-4 parts of sweet wormwood, Radix Glycyrrhizae 1-2
Part.
The preparation method of the Chinese medicine composition of above-mentioned prevention Trichomonad of dove, this approach includes the following steps：
(1) leaching is collected in kuh-seng, Changshan, Chinese bulbul citric acid soln 75-85 DEG C of (PH2 citric acids) hot dipping 9-11 hours
Liquid is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(2) 75-85 DEG C of hot dipping of ethyl alcohol 24 hours of sweet wormwood 40-50wt% collects immersion liquid and is concentrated into mass concentration and make a living
The doubling dose (m/v) of medicine；
(3) smilax with the ethyl alcohol and ethyl acetate of 70-80wt% with volume ratio be 1:The mixed solution extraction of 1 mixing,
It collects extract liquor and is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(4) Radix Glycyrrhizae boiling pure water 20-30 minutes, removes slag, and is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(5) merge whole liquids that above-mentioned steps obtain and obtain the Chinese medicine composition of prevention Trichomonad of dove.
Particularly, for expanded service life, the Chinese medicine composition is additionally added the alcohol and benzene that mass concentration is 70%
Sodium formate anti-corrosion, and dispense and obtain Chinese medicine preparation；By total mass fraction be 100% based on, mass concentration be 70% alcohol
Mass fraction is 10-15% in preparation, and mass fraction is 0.05-0.1% to sodium benzoate in the formulation.
The present invention also protects application of the Chinese medicine composition of above-mentioned prevention Trichomonad of dove in preventing Trichomonad of dove, institute
It states Chinese medicine composition to be added in drinking-water, additive amount is 0.5-1ml/ plumages/day drinking-water, is used in conjunction 3-7 days.
This Chinese medicine preparation be based on the characteristics of incidence of principles combination Trichomonad of dove such as traditional Chinese veterinary medicine " righting and eliminating evil " with
Pigeon growth life characteristic develops, and the quality standard of product of the present invention is：Sepia, slightly muddy solution；Gas is fragrant, bitter,
Micro-pungent；Relative density should be not less than 1.05；PH value is between 3.0-5.0；± the 0.005g/ml of 0.125g containing crude drug amount.Heat-clearing solution
Poison, desinsection dampness removing.
As the Chinese medicine composition drug concentration 1.0mg/ml, 2h and 4h polypide relative survival rates are respectively in vitro test
75%, 50%, with drug time lengthening, polypide survival rate continues to decline, and arrives 16h polypides survival rate 0%, polypide is killed completely
Extremely.Feeding experiment shows there is apparent preventive and therapeutic action to Trichomonad of dove.Meanwhile the Chinese medicine composition is as pure
Chinese herbal and crude drugs preparations have the characteristics that pure natural, noresidue, are the ideal medicaments of pigeon for meat aquaculture prevention Trichomonad of dove.
Beneficial effects of the present invention are as follows：
1, the present composition prevents Trichomonad of dove significant effect, hence it is evident that is better than the similar achievement in research of metronidazole.This hair
Bright composition is clearing heat and detoxicating, desinsection dampness removing.In vitro test proves there is the apparent killing trichomonal effect of dove.Pass through microscope
It was found that this pure Chinese herbal medicine preparation can be such that the trichomonal polypide of dove cracks, it is better than metronidazole.During pilot plant test shows that this is pure
Herbal medicinal product can prevent for supporting dove dove group's prevention Trichomonad of dove with 100%, is used in conjunction 5 days and drinks water, detects dove trichmonad band
Worm rate is 0%.Reach 98% or more for supporting dove morbidity dove group's treatment Trichomonad of dove cure rate.
2, the present invention has the characteristics that pure natural, noresidue as pure Chinese herbal medicine preparation, has to Trichomonad of dove apparent
Preventive and therapeutic action, can substitute the use of metronidazole, solve medicament residue problem caused by metronidazole, bacterial drug resistance
Problem has significant public health meaning and environment protection significance.
Specific implementation mode：
It is the further explanation to the present invention below, rather than limiting the invention.
Embodiment 1：
A kind of Chinese medicine composition of prevention Trichomonad of dove, by the Chinese medicinal composition of following parts by weight：5 parts of kuh-seng, Changshan 5
Part, 4 parts of smilax, 3 parts of the Chinese bulbul, 3 parts of sweet wormwood, 2 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned prevention Trichomonad of dove, this approach includes the following steps：
(1) immersion liquid concentration is collected in kuh-seng, Changshan, the Chinese bulbul 80 DEG C of citric acid soln (PH2 citric acids) hot dipping 10 hours
To the doubling dose (m/v) that mass concentration is crude drug；
(2) 80 DEG C of the ethyl alcohol hot dipping 24 hours of sweet wormwood 45wt% collects immersion liquid and is concentrated into mass concentration as the two of crude drug
Amount (m/v) again；
(3) smilax with the ethyl alcohol and ethyl acetate of 75wt% with volume ratio be 1:The mixed solution extraction of 1 mixing, is collected
Extract liquor is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(4) Radix Glycyrrhizae boiling pure water 20 minutes, removes slag, and is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(5) merge whole liquids that above-mentioned steps obtain and obtain the Chinese medicine composition of prevention Trichomonad of dove.
Somewhere large size dove, raises that white plumage meat pigeon for meat 5000 is right, and September starts on the 7th within 2015, and 10-18 age in days squabs occur
Morbidity is dead, incidence 15%, the death rate 5%.Sick dove spiritual depressed, few food occurs or appetite is useless exhausted, mouth breathing, and oral cavity is glutinous
Film thickens, and has the light yellow precipitate to differ in size.Dissect is died of illness dove, and oral cavity, esophagus, crop have a large amount of yellow-white necrosis regions,
Air bag muddiness thickens, and has caseous necrosis object.Through laboratory diagnosis, all morbidity doves detect trichmonad, are diagnosed as dove hair
Trichomoniasis.Then, September starts to use the present embodiment traditional Chinese medicine composition for treating on the 7th, and according to 1ml/ plumages/day, drinking-water is used in conjunction 7 days,
Full flock pigeon gets well, and there is no morbidity case, cure rates 100%.
Embodiment 2,
A kind of Chinese medicine composition of prevention Trichomonad of dove, by the Chinese medicinal composition of following parts by weight：6 parts of kuh-seng, Changshan 6
Part, 4 parts of smilax, 2 parts of the Chinese bulbul, 2 parts of sweet wormwood, 2 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned prevention Trichomonad of dove, this approach includes the following steps：
(1) immersion liquid concentration is collected in kuh-seng, Changshan, the Chinese bulbul 80 DEG C of citric acid soln (PH2 citric acids) hot dipping 10 hours
To the doubling dose (m/v) that mass concentration is crude drug；
(2) 80 DEG C of the ethyl alcohol hot dipping 24 hours of sweet wormwood 45wt% collects immersion liquid and is concentrated into mass concentration as the two of crude drug
Amount (m/v) again；
(3) smilax with the ethyl alcohol and ethyl acetate of 75wt% with volume ratio be 1:The mixed solution extraction of 1 mixing, is collected
Extract liquor is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(4) Radix Glycyrrhizae boiling pure water 20 minutes, removes slag, and is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(5) merge whole liquids that above-mentioned steps obtain and obtain the Chinese medicine composition of prevention Trichomonad of dove；
(6) Chinese medicine composition obtained in step (5) is additionally added alcohol and the sodium benzoate anti-corrosion that mass concentration is 70%,
And it dispenses and obtains Chinese medicine preparation；It is the quality in the formulation point for the alcohol that mass concentration is 70% based on 100% by total mass fraction
Number is 10%, and mass fraction is 0.1% to sodium benzoate in the formulation.
In December, 2015, certain dove field break out shed tears together with squab expiratory dyspnea, photophobia, oral mucosa thickens mainly to face
The disease of bed symptom is diagnosed as squab trichomoniasis and colibacillosis mixed infection through dissect and laboratory examination.Then,
The Chinese medicine preparation treatment obtained using the present embodiment, according to 1ml/ plumages/day, drinking-water is used in conjunction 7 days, full flock pigeon gets well, no
There are morbidity case, cure rate 100% again.
Embodiment 3,
Reference implementation example 2, the difference is that Chinese medicine composition, by the Chinese medicinal composition of following parts by weight：5 parts of kuh-seng, often
5 parts of mountain, 6 parts of smilax, 4 parts of the Chinese bulbul, 4 parts of sweet wormwood, 1 part of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned prevention Trichomonad of dove, this approach includes the following steps：
(1) (immersion liquid concentration is collected in the hot dipping 11 hours of 75 DEG C of PH2 citric acids with citric acid soln for kuh-seng, Changshan, the Chinese bulbul
To the doubling dose (m/v) that mass concentration is crude drug；
(2) 85 DEG C of the ethyl alcohol hot dipping 24 hours of sweet wormwood 40wt% collects immersion liquid and is concentrated into mass concentration as the two of crude drug
Amount (m/v) again；
(3) smilax with the ethyl alcohol and ethyl acetate of 80wt% with volume ratio be 1:The mixed solution extraction of 1 mixing, is collected
Extract liquor is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(4) Radix Glycyrrhizae boiling pure water 30 minutes, removes slag, and is concentrated into the doubling dose (m/v) that mass concentration is crude drug；
(5) merge whole liquids that above-mentioned steps obtain and obtain the Chinese medicine composition of prevention Trichomonad of dove；
(6) Chinese medicine composition obtained in step (5) is additionally added alcohol and the sodium benzoate anti-corrosion that mass concentration is 70%,
And it dispenses and obtains Chinese medicine preparation；It is the quality in the formulation point for the alcohol that mass concentration is 70% based on 100% by total mass fraction
Number is 15%, and mass fraction is 0.05% to sodium benzoate in the formulation.
In April, 2016, certain large-scale dove livestock on hand share 5 dovecotes, and every dovecote 3000 is to producing dove, in December, 2017,
In a dovecote occur that 8-15 days ages squab is dead, and the death rate 3% or so is after diagnosing Trichomonad of dove.Then, morbidity dovecote
Using this pure embodiment Chinese medicine preparation treatment, according to 1ml/ plumages/day, drinking-water is used in conjunction 5 days, and morbidity flock pigeon gets well, no longer
There are morbidity case, cure rate 100%.There is epidemic situation simultaneously to prevent other dovecotes, so dovecote is all made of dove drop clearly, according to
All there is not epidemic situation, prevent success rate 100% in 0.5ml/ plumages/day drinking-water, all dovecotes.
Embodiment 4,
Reference implementation example 2, the difference is that Chinese medicine composition, by the Chinese medicinal composition of following parts by weight：7 parts of kuh-seng, often
4 parts of mountain, 4 parts of smilax, 2 parts of the Chinese bulbul, 4 parts of sweet wormwood, 1 part of Radix Glycyrrhizae.
The preparation reference implementation example 2 of Chinese medicine preparation.
In November, 2017, certain dove field reserve seed for planting with young pigeon 2000, fall ill, and initial symptoms are spiritual depressed, appetite
Decline, sick dove oral cavity have yellow sphacelus, morbidity to occur death after 3 days, fall ill the 7th day, and fall ill dove 57, death
23.Through laboratory diagnosis, it is diagnosed as Trichomonad of dove.Then, mine massively entirely with this pure Chinese medicinal preparation (treatment, according to 1ml/ plumages/
It, drinking-water is used in conjunction 7 days, and morbidity flock pigeon gets well, and does not have new case, cure rate 100%.
Claims (7)
1. a kind of Chinese medicine composition of prevention Trichomonad of dove, which is characterized in that by the Chinese medicinal composition of following parts by weight：Kuh-seng 4-
8 parts, 4-8 parts of Changshan, 4-8 parts of smilax, 2-6 parts of the Chinese bulbul, 2-6 parts of sweet wormwood, 1-3 parts of Radix Glycyrrhizae.
2. preventing the Chinese medicine composition of Trichomonad of dove according to claim 1, which is characterized in that by following parts by weight
Medicine forms：5-7 parts of kuh-seng, 4-6 parts of Changshan, 4-6 parts of smilax, 2-4 parts of the Chinese bulbul, 2-4 parts of sweet wormwood, 1-2 parts of Radix Glycyrrhizae.
3. preventing the preparation method of the Chinese medicine composition of Trichomonad of dove described in a kind of claim 1, which is characterized in that this method
Include the following steps：
(1) kuh-seng, Changshan, Chinese bulbul 75-85 DEG C of citric acid soln hot dipping 9-11 hours collect immersion liquid and are concentrated into mass concentration
For the doubling dose of crude drug；
(2) 75-85 DEG C of hot dipping of ethyl alcohol 24 hours of sweet wormwood 40-50wt%, it is crude drug to collect immersion liquid and be concentrated into mass concentration
Doubling dose；
(3) smilax with the ethyl alcohol and ethyl acetate of 70-80wt% with volume ratio be 1:The mixed solution extraction of 1 mixing, is collected
Extract liquor is concentrated into the doubling dose that mass concentration is crude drug；
(4) Radix Glycyrrhizae boiling pure water 20-30 minutes, removes slag, and is concentrated into the doubling dose that mass concentration is crude drug；
(5) merge whole liquids that above-mentioned steps obtain and obtain the Chinese medicine composition of prevention Trichomonad of dove.
4. preventing application of the Chinese medicine composition of Trichomonad of dove in preventing Trichomonad of dove described in claim 1.
5. application of the Chinese medicine composition of prevention Trichomonad of dove in preventing Trichomonad of dove according to claim 4,
It is characterized in that, Chinese medicine composition is added in drinking-water, and additive amount is 0.5-1ml/ plumages/day drinking-water, is used in conjunction 3-7 days.
6. a kind of Chinese medicine preparation, which is characterized in that the Chinese medicine composition for preventing Trichomonad of dove described in claim 1 is additionally added matter
A concentration of 70% alcohol and sodium benzoate anti-corrosion are measured, and dispenses and obtains Chinese medicine preparation；It is matter based on 100% by total mass fraction
The mass fraction in the formulation for measuring a concentration of 70% alcohol is 10-15%, and mass fraction is 0.05- to sodium benzoate in the formulation
0.1%.
7. application of the Chinese medicine preparation described in claim 6 in preventing Trichomonad of dove.
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Cited By (2)
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| CN112826885A (en) * | 2021-02-04 | 2021-05-25 | 郑志勇 | Traditional Chinese medicine formula for treating trichomonas columbae |
| CN113143938A (en) * | 2021-03-15 | 2021-07-23 | 中国农业科学院北京畜牧兽医研究所 | Application of bile acid in inhibiting trichomonas columbae activity in vitro |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112826885A (en) * | 2021-02-04 | 2021-05-25 | 郑志勇 | Traditional Chinese medicine formula for treating trichomonas columbae |
| CN113143938A (en) * | 2021-03-15 | 2021-07-23 | 中国农业科学院北京畜牧兽医研究所 | Application of bile acid in inhibiting trichomonas columbae activity in vitro |
| CN113143938B (en) * | 2021-03-15 | 2022-05-03 | 中国农业科学院北京畜牧兽医研究所 | Application of bile acid in inhibiting trichomonas columbae activity in vitro |
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