CN101579481B - Medicinal composition for treating hypertension - Google Patents
Medicinal composition for treating hypertension Download PDFInfo
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- CN101579481B CN101579481B CN2008101067732A CN200810106773A CN101579481B CN 101579481 B CN101579481 B CN 101579481B CN 2008101067732 A CN2008101067732 A CN 2008101067732A CN 200810106773 A CN200810106773 A CN 200810106773A CN 101579481 B CN101579481 B CN 101579481B
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Abstract
The invention discloses a medicinal composition for treating hypertension and a preparation method thereof. The composition consists of extracts of red infested rice, uncaria and dendrobium. The extracts are extracted by the prior method. The medicinal composition is added with the conventional accessories and made into clinically acceptable medicament formulations such as tablets, capsules, pulvis, soft capsules, dripping pills and the like according to the prior process. The medicinal composition has remarkable effect of treating the hypertension and no side effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to the hypertensive pharmaceutical composition of a kind of treatment.
Background technology
Hypertension is by polygenic inheritance and environment and the interactional a kind of systemic disease of multiple risk factor, is a kind of global commonly encountered diseases, frequently-occurring disease, is to cause one of human cardiovascular and cerebrovascular disease main causes of death at present.Sickness rate is the principal disease of harm humans health up to 10-20% in the world wide.China is the country occurred frequently of essential hypertension.91 years according to high altitude hypertension standard generaI investigation, China more than 15 years old the hypertension prevalence be 13.58%.By this sickness rate, China has about 200,000,000 people of hyperpietic now.If press the existing standard diagnosis, the hypertension incidence patient can be more.But phenomenon that China's hypertension is popular to be existed " three Senior Three are low ", that is: hypertensive prevalence height, disability rate height and mortality rate height, awareness is low, the rate of taking medicine low and control rate is low.The heart that hypertension caused, brain, kidney be last target organ damage and the cardiovascular and cerebrovascular vessel incident that causes has seriously influenced quality of life eventually, is referred to as " noiseless killer ".To this, ministry of Health of China proposes the hypertension day of annual October 8 as China, and require the resident more than 35 years old to detect blood pressure every year at least one time, Here it is fundamentally calls national people and all medical personnels clearly to be familiar with hypertensive harm, actively prevents and treats hypertension.
At present modern medicine has 6 classes substantially to hypertensive medicine: 1. diuretic 2. α receptor blocking agents 3. beta-blockers 4. calcium ion antagonists 5. angiotensin converting enzyme inhibitors 6. angiotensin ii receptor antagonist.Along with the progress with the cardiovascular molecular biology research of carrying out of extensive resisting hypertension clinical trial, hypertensive traditional understanding has obtained renewal in recent years, and following disease medical science has become common recognition.Hypertension is not only the hemodynamic abnormalities disease, and follows the bad of target organ such as fat, carbohydrate metabolism disturbance and heart and brain kidney to reinvent.Therefore treatment will improve above-mentioned all metabolism disorders, prevention and the bad of reverse target organ and reinvent in effective controlling blood pressure level.This is to reduce the generation of cardiovascular complication and the key of case fatality rate.Though very much progress is all arranged on theory research and clinical efficacy than before.But because antihypertensive drugs still has arguement to the influence of metabolism and target organ damage, and all exists certain side effect mostly, part has limited its clinical practice.Making hypertensive control can not use up the people is willing to.
Tradition Chinese traditional treatment hypertension lay special stress on organic conception, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, regulating yin and yang, too many levels conditioning, this has similar to modern medicine to the transformation of hypertension treatment viewpoint and the part of coincideing, and demonstrating Chinese medicine has certain advantage aspect hypertension treatment.And Chinese medicine is inexpensive, toxic and side effects is little, it is little that target organ is influenced.
Summary of the invention
The object of the invention is to provide a kind of treatment hypertensive pharmaceutical composition.
Another object of the present invention is to provide the new purposes of this pharmaceutical composition extract.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Monas cuspurpureus Went extract 1-5 Chong Liang Fen Hook rattan extract 3-8 weight portion
Herba Dendrobii extract 1-5 weight portion
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 3 Chong Liang Fen Hook rattan extract 5 weight portion Herba Dendrobii extracts 3 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 2 Chong Liang Fen Hook rattan extract 7 weight portion Herba Dendrobii extracts 4 weight portions
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Monas cuspurpureus Went extract 4 Chong Liang Fen Hook rattan extract 4 weight portion Herba Dendrobii extracts 2 weight portions
Extract of the present invention is made by conventional method, includes but not limited to that water extract, ethanol extract or water extract-alcohol precipitation cross the macroporous resin column extract.
Described water extraction method includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocts 1-2 hour at every turn, merges decocting liquid, and concentrate drying must this medical material water extract.Perhaps get arbitrary medical material in the crude drug of the present invention, decocting boils 1-2 time, adds 4-8 times of water gaging respectively, decocted 1-2 hour, and merged decocting liquid, being concentrated into relative density is 1-1.1, centrifugal, supernatant is crossed macroporous resin column, and water lotion is abandoned in washing, the 30-80% ethanol elution, reclaim ethanol, concentrate drying must this medical material water extract.
Described decoction and alcohol sedimentation technique includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 2-3 time, add 4-8 times of water gaging respectively, decocted 1-2 hour, merge decocting liquid, being concentrated into relative density is 1-1.1, centrifugal, supernatant added 4-8 times of weight 30-80% ethanol precipitation 24 hours, reclaimed ethanol, concentrate drying must this medical material water extract-alcohol precipitation extract.
Described water extract-alcohol precipitation is crossed macropore adsorption column method and is included but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, decocting boils 2-3 time, adds 4-8 times of water gaging respectively, decocted 1-2 hour, and merged decocting liquid, being concentrated into relative density is 1-1.1, centrifugal, supernatant added 4-8 times of weight 30-80% ethanol precipitation 24 hours, reclaimed ethanol, be concentrated into relative density and be 1-1.1, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate drying must be crossed macropore adsorption column extract by this medical material water extract-alcohol precipitation.
Described supercritical extraction includes but not limited to following method:
Get arbitrary medical material in the crude drug of the present invention, supercritical CO
2Extraction adds in the 10-40% crude drug of the present invention arbitrary medical material amount 75-95% ethanol and makes entrainer, and extracting pressure 20-40Mpa, temperature 30-60 ℃, must this medical material supercritical extract.Perhaps get arbitrary medical material in the crude drug of the present invention, behind the supercritical extraction, medicated powder is taken out, decocting boils 1-2 time, add 6-8 times of water gaging respectively, decocted 0.5-1 hour, merge decocting liquid, concentrate, add 75-95% ethanol and make and contain alcohol amount and reach 60-80%, left standstill 12-24 hour, filter, the filtrate concentrate drying must this medical material supercritical CO
2Extraction water extract-alcohol precipitation extract.
Pharmaceutical composition of the present invention adds conventional adjuvant, according to common process, make tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, soft extract with bee honey agent, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
Medicine composite for curing hypertension effect of the present invention significantly and have no side effect.
Experiment and embodiment are used to further specify but are not limited to the present invention below.
Pharmaceutical composition of the present invention reaches 96% through clinical treatment hypertension 120 routine patient's total effective rates, and diagnostic criteria of hypertension case and criterion of therapeutical effect are pressed the Ministry of Public Health standard and confirmed, 110 routine produce effects wherein, 4 examples effectively, 6 examples are invalid.See the following form
| Criterion of therapeutical effect | Produce effects (routine number) | Effectively (routine number) | Invalid (routine number) |
| 120 examples | 110 examples | 5 examples | 5 examples |
| Effective percentage | 92％ | 4％ | 4％ |
The specific embodiment
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1:
Monas cuspurpureus Went water extract 3kg Hook rattan water extract 5kg Herba Dendrobii water extract 3kg
Said medicine adds conventional adjuvant according to common process and makes capsule.
Embodiment 2:
Monas cuspurpureus Went alcohol extract 2kg Hook rattan water extract 7kg Herba Dendrobii alcohol extract 4kg
Said medicine adds conventional adjuvant according to common process and makes oral liquid.
Embodiment 3:
Monas cuspurpureus Went alcohol extract 4kg Hook rattan alcohol extract 4kg Herba Dendrobii water extract 2kg
Said medicine adds conventional adjuvant according to common process and makes slow releasing tablet.
Embodiment 4:
Monas cuspurpureus Went water extract 2kg Hook rattan alcohol extract 3kg Herba Dendrobii alcohol extract 2kg
Said medicine adds conventional adjuvant according to common process and makes lyophilized injectable powder.
Embodiment 5:
The Monas cuspurpureus Went water extract-alcohol precipitation is crossed macroporous resin column extract 4kg
Hook rattan water extract-alcohol precipitation is crossed macroporous resin column extract 8kg
The Herba Dendrobii water extract-alcohol precipitation is crossed macroporous resin column extract 4kg
Said medicine adds conventional adjuvant according to common process and makes injection.
Claims (7)
1. treat hypertensive pharmaceutical composition for one kind, it is characterized in that this pharmaceutical composition crude drug consists of:
Monas cuspurpureus Went extract 1-5 Chong Liang Fen Hook rattan extract 3-8 weight portion Herba Dendrobii extract 1-5 weight portion; Described extract is made by conventional method.
2. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of:
Monas cuspurpureus Went extract 3 Chong Liang Fen Hook rattan extract 5 weight portion Herba Dendrobii extracts 3 weight portions.
3. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of:
Monas cuspurpureus Went extract 2 Chong Liang Fen Hook rattan extract 7 weight portion Herba Dendrobii extracts 4 weight portions.
4. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of:
Monas cuspurpureus Went extract 4 Chong Liang Fen Hook rattan extract 4 weight portion Herba Dendrobii extracts 2 weight portions.
5. as the described pharmaceutical composition of one of claim 1-4, it is characterized in that this pharmaceutical composition adds conventional adjuvant, according to common process, make tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, soft extract with bee honey agent, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
6. preparation of drug combination method as claimed in claim 5, it is characterized in that this method is: in this pharmaceutical composition, add conventional adjuvant, according to common process, make tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, soft extract with bee honey agent, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
7. as the application of the described pharmaceutical composition of one of claim 1-4 in the hypertensive medicine of preparation treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101067732A CN101579481B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating hypertension |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101067732A CN101579481B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101579481A CN101579481A (en) | 2009-11-18 |
| CN101579481B true CN101579481B (en) | 2011-04-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101067732A Active CN101579481B (en) | 2008-05-15 | 2008-05-15 | Medicinal composition for treating hypertension |
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| CN (1) | CN101579481B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101735888B (en) * | 2009-12-09 | 2012-09-26 | 浙江森宇实业有限公司 | Extraction method to produce dendrobium flowers volatile oil |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091027A (en) * | 1993-07-14 | 1994-08-24 | 张成元 | Blood-pressure reducing plaster sticking on acupoint and preparation method thereof |
| CN1175445A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Brain refreshing pill for dizziness |
-
2008
- 2008-05-15 CN CN2008101067732A patent/CN101579481B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091027A (en) * | 1993-07-14 | 1994-08-24 | 张成元 | Blood-pressure reducing plaster sticking on acupoint and preparation method thereof |
| CN1175445A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Brain refreshing pill for dizziness |
Non-Patent Citations (1)
| Title |
|---|
| 李祥农.高血压病中医治法浅议.《中国实用医药》.2007,第2卷(第2期),120-121. * |
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| CN101579481A (en) | 2009-11-18 |
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