CN101579439A - Antifatigue traditional Chinese medicine preparation - Google Patents
Antifatigue traditional Chinese medicine preparation Download PDFInfo
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- CN101579439A CN101579439A CNA2009101516327A CN200910151632A CN101579439A CN 101579439 A CN101579439 A CN 101579439A CN A2009101516327 A CNA2009101516327 A CN A2009101516327A CN 200910151632 A CN200910151632 A CN 200910151632A CN 101579439 A CN101579439 A CN 101579439A
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- chinese medicine
- preparation
- radix rehmanniae
- rehmanniae preparata
- antifatigue
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Abstract
The invention relates to an antifatigue traditional Chinese medicine preparation in the field of natural traditional Chinese medicine preparations. The raw materials of the preparation include: Cistanche salsa, prepared rehmannia root, seeds of Chinese Dodder and shizandra berry steamed with wine. The preparation can nourish kidney-yin, strengthen muscle and bone, prolong the swimming time of loaded rats and relieve the accumulation of lactic acid in serum and skeletal muscle, thus achieving the antifatigue effect.
Description
Technical field
The present invention relates to a kind of treatment antifatigue Chinese medicine preparation, have nourishing kidney yin, the effect of bone and muscle strengthening the present invention relates to Chinese medicine natural medicinal formulations field, is particularly useful for suffering from a deficiency of the kidney, the soreness of waist not endurance and the sexual impotence that occurs together.
Technical background
The Bolus as a Kidney-Yin-Tonic beginning is stated from the Jing-Yue Complete Works that the Ming Dynasty cures tame Zhang Jiebin, is the special side of a first nourishing kidney yin.This side is made up of eight herbal medicines such as Radix Rehmanniae Preparata, Semen Cuscutae, Radix Achyranthis Bidentatae, Colla Plastri Testudinis, Colla cornus cervi, Rhizoma Dioscoreae, Fructus Corni, Fructus Lycii, and common development is a kind of Chinese patent medicine commonly used for pill.The function enriching yin and nourishing kidney are used for diseases such as kidney-YIN being deficient, soreness of waist and knee, night sweat, impotence and seminal emission, Mental fatigue dryness of the tongue.Clinically, lethargy, soreness of waist lumbago, be short of physical strength, the many or urine of poor sleep (comprising insomnia, dreaminess, drowsiness), sexual hypofunction, seminal emission, urine amount as fat, have a dizzy spell, tinnitus, deafness, xerostomia, night sweat, low grade fever, feverish sensation in the palms and soles etc. can reduce " suffering from a deficiency of the kidney "., the traditional Chinese medical science saidly suffers from a deficiency of the kidney, the soreness of waist is consistent with the sub-health state of doctor trained in Western medicine approval.Definite says if owing to suffering from a deficiency of the kidney that function causes, be equal to the said subhealth state of doctor trained in Western medicine in fact.Bolus as a Kidney-Yin-Tonic is a conventional formulation, and treatment is suffered from a deficiency of the kidney, the effect of the soreness of waist though have, and medicine material is numerous and diverse, and part material is from animal, and technology is outmoded.Market demand medicine source is simply abundant, take easy, determined curative effect, quality controllable modern Chinese medicine preparation.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine for the treatment of male sexual disorder.
For realizing above purpose, the present invention makes capsule or suitable pharmaceutical dosage form at the prescription medical material based on Chinese medicine through extraction, and the raw material group of preparation of the present invention is:
Herba Cistanches, Radix Rehmanniae Preparata, Semen Cuscutae, wine Fructus Schisandrae Chinensis (steamed).
Each medical material weight adopts following proportioning to make 4000 of capsules:
Herba Cistanches, Radix Rehmanniae Preparata, Semen Cuscutae, wine Fructus Schisandrae Chinensis (steamed) are 1004.8g by the medical material weight proportion: 1004.8: 1004.8: 16.5g.
Method for making is: above four Chinese medicine material, Radix Rehmanniae Preparata decoct with water 10 times of water gagings twice, the 1 time, the 2nd 8 times of water gagings, and each 2 hours, decocting liquid filtered, and filtrate merging is concentrated into the thick paste of relative density 1.27～1.32 (20 ℃ ~ 25 ℃); Semen Cuscutae is made solvent with 45% ethanol, floods to carry out percolation after 24 hours, collects percolate to closely colourless, reclaims ethanol and is concentrated into the clear paste of relative density 1.10～1.15 (20 ℃～25 ℃), with Radix Rehmanniae Preparata thick paste mix homogeneously, drying, pulverizes, and is standby; Herba Cistanches, Fructus Schisandrae Chinensis powder are broken into fine powder; With the dried cream powder mixing, add appropriate amount of starch, mixing is made granule, incapsulates, and makes 1000, promptly.
Illustrate that through control experiment this preparation has outstanding effect to treatment sexual impotence aspect.
By observing this preparation to castration buck erection incubation period with to the influence of sexual organ's weight and organ index, this preparation can significantly shorten castration male rat erection incubation period, increase castration mouse sexual organ weight, make the yang deficiency mouse temperature descend, lose weight, stress ability descends, the symptom of movable minimizing significantly improves.
Preparation capsule 's content 0.4g of the present invention takes 3 every day, each 4.Content standard and detection method are: according to the Chinese Pharmacopoeia high effective liquid chromatography for measuring.
[assay] is according to high performance liquid chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 D)
Chromatographic condition and system suitability test are filler with the octadecylsilane chemically bonded silica; With second eyeball-methanol-1% glacial acetic acid (13: 9: 78) is mobile phase; The detection wavelength is 334nm; Column temperature is 40 ℃: number of theoretical plate must not be lower than 3000 by the acteoside peak.
It is an amount of that the acteoside reference substance is got in the preparation of reference substance solution, accurate claims surely, with dissolve with methanol and be diluted to scale, shakes up, and makes the solution that every 1ml contains 36 μ g, promptly.
This product content under the content uniformity item is got in the preparation of need testing solution, mixing, and porphyrize is got the about 1.0g of powder, the accurate title, decide, and puts in the brown measuring bottle of 100ml, accurate methanol 50ml, the close plug of adding, shake up, precision is weighed, and soaks supersound process (power 250W 0.5 hour, frequency 40kHz) 40 minutes, put coldly, claim again to decide weight, supply the weight that subtracts mistake with methanol, shake up, centrifugal 10 minutes (2500 rev/mins) get supernatant, filter, get subsequent filtrate, promptly.
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, promptly.
Every of this product contains Herba Cistanches with acteoside (C
29H
36O
15) meter, must not be less than 0.29mg.
The specific embodiment:
Embodiment 1: the capsular preparation of the present invention
Herba Cistanches 251.2g Radix Rehmanniae Preparata 251.2g
Semen Cuscutae 251.2g Fructus Schisandrae Chinensis (wine steaming) 4.125g
Above four Chinese medicine material, Radix Rehmanniae Preparata decoct with water 10 times of water gagings twice, the 1 time, the 2nd 8 times of water gagings, and each 2 hours, decocting liquid filtered, and filtrate merging is concentrated into the thick paste of relative density 1.27～1.32 (20 ℃ ~ 25 ℃); Semen Cuscutae is made solvent with 45% ethanol, floods to carry out percolation after 24 hours, collects percolate to closely colourless, reclaims ethanol and is concentrated into the clear paste of relative density 1.10～1.15 (20 ℃～25 ℃), with Radix Rehmanniae Preparata thick paste mix homogeneously, drying, pulverizes, and is standby; Herba Cistanches, Fructus Schisandrae Chinensis powder are broken into fine powder; With the dried cream powder mixing, add appropriate amount of starch, mixing is made granule, incapsulates, and makes 1000, promptly.
Embodiment 2: the preparation of extract of the present invention
Herba Cistanches 251.2g Radix Rehmanniae Preparata 251.2g
Semen Cuscutae 251.2g Fructus Schisandrae Chinensis (wine steaming) 4.125g
Above four Chinese medicine material, Radix Rehmanniae Preparata decoct with water 10 times of water gagings twice, the 1 time, the 2nd 8 times of water gagings, and each 2 hours, decocting liquid filtered, and filtrate merging is concentrated into the thick paste of relative density 1.27～1.32 (20 ℃ ~ 25 ℃); Semen Cuscutae is made solvent with 45% ethanol, floods to carry out percolation after 24 hours, collects percolate to closely colourless, reclaims ethanol and is concentrated into the clear paste of relative density 1.10～1.15 (20 ℃～25 ℃), with Radix Rehmanniae Preparata thick paste mix homogeneously, drying, pulverizes, and is standby; Herba Cistanches, Fructus Schisandrae Chinensis powder are broken into fine powder; With the dried cream powder mixing.
Embodiment 3: preparation of soft capsule of the present invention
Herba Cistanches 251.2g Radix Rehmanniae Preparata 251.2g
Semen Cuscutae 251.2g Fructus Schisandrae Chinensis (wine steaming) 4.125g
Above four Chinese medicine material, Radix Rehmanniae Preparata decoct with water 10 times of water gagings twice, the 1 time, the 2nd 8 times of water gagings, and each 2 hours, decocting liquid filtered, and filtrate merging is concentrated into the thick paste of relative density 1.27～1.32 (20 ℃ ~ 25 ℃); Semen Cuscutae is made solvent with 45% ethanol, floods to carry out percolation after 24 hours, collects percolate to closely colourless, reclaims ethanol and is concentrated into the clear paste of relative density 1.10～1.15 (20 ℃～25 ℃), with Radix Rehmanniae Preparata thick paste mix homogeneously, drying, pulverizes, and is standby; Herba Cistanches, Fructus Schisandrae Chinensis powder are broken into fine powder; With the dried cream powder mixing.Modulation capsule liquid is made the soft capsule capsule, promptly.
Embodiment 4: the particulate preparation of the present invention
Herba Cistanches 251.2g Radix Rehmanniae Preparata 251.2g
Semen Cuscutae 251.2g Fructus Schisandrae Chinensis (wine steaming) 4.125g
Above four Chinese medicine material, Radix Rehmanniae Preparata decoct with water 10 times of water gagings twice, the 1 time, the 2nd 8 times of water gagings, and each 2 hours, decocting liquid filtered, and filtrate merging is concentrated into the thick paste of relative density 1.27～1.32 (20 ℃ ~ 25 ℃); Semen Cuscutae is made solvent with 45% ethanol, floods to carry out percolation after 24 hours, collects percolate to closely colourless, reclaims ethanol and is concentrated into the clear paste of relative density 1.10～1.15 (20 ℃～25 ℃), with Radix Rehmanniae Preparata thick paste mix homogeneously, drying, pulverizes, and is standby; Herba Cistanches, Fructus Schisandrae Chinensis powder are broken into fine powder; With the dried cream powder mixing.Add suitable adjuvant, granulate, drying, promptly.
Embodiment 5: content detection of the present invention:
Herba Cistanches 251.2g Radix Rehmanniae Preparata 251.2g
Semen Cuscutae 251.2g Fructus Schisandrae Chinensis (wine steaming) 4.125g
Above four Chinese medicine material, Radix Rehmanniae Preparata decoct with water 10 times of water gagings twice, the 1 time, the 2nd 8 times of water gagings, and each 2 hours, decocting liquid filtered, and filtrate merging is concentrated into the thick paste of relative density 1.27～1.32 (20 ℃ ~ 25 ℃); Semen Cuscutae is made solvent with 45% ethanol, floods to carry out percolation after 24 hours, collects percolate to closely colourless, reclaims ethanol and is concentrated into the clear paste of relative density 1.10～1.15 (20 ℃～25 ℃), with Radix Rehmanniae Preparata thick paste mix homogeneously, drying, pulverizes, and is standby; Herba Cistanches, Fructus Schisandrae Chinensis powder are broken into fine powder; With the dried cream powder mixing, add appropriate amount of starch, mixing is made granule, incapsulates, and makes 1000, promptly.
According to the Chinese Pharmacopoeia high effective liquid chromatography for measuring.
[assay] is according to high performance liquid chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 D)
Chromatographic condition and system suitability test are filler with the octadecylsilane chemically bonded silica; With second eyeball-methanol-1% glacial acetic acid (13: 9: 78) is mobile phase; The detection wavelength is 334nm; Column temperature is 40 ℃: number of theoretical plate must not be lower than 3000 by the acteoside peak.
It is an amount of that the acteoside reference substance is got in the preparation of reference substance solution, accurate claims surely, with dissolve with methanol and be diluted to scale, shakes up, and makes the solution that every 1ml contains 36 μ g, promptly.
This product content under the content uniformity item is got in the preparation of need testing solution, mixing, and porphyrize is got the about 1.0g of powder, the accurate title, decide, and puts in the brown measuring bottle of 100ml, accurate methanol 50ml, the close plug of adding, shake up, precision is weighed, and soaks supersound process (power 250W 0.5 hour, frequency 40kHz) 40 minutes, put coldly, claim again to decide weight, supply the weight that subtracts mistake with methanol, shake up, centrifugal 10 minutes (2500 rev/mins) get supernatant, filter, get subsequent filtrate, promptly.
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, promptly.
Every of this product contains Herba Cistanches with acteoside (C
29H
36O
15) meter, must not be less than 0.29mg.
Embodiment 6: the pharmacological evaluation of this preparation
120 male SD rats are divided into model group at random, reach the high, medium and low dosage group of the yellow the kidney invigorating extract of desert, 20 every group; Other establishes 10 rats as the blank group.Except that the blank group, after all the other each groups are given corresponding pharmaceutical intervention 10d respectively, get 10 rats at random for every group and adopt swimming with a load attached to the body power to exhaust laboratory observation exhausts swimming time to rat power influence; Observe the variation of serum lactic acid, blood urea nitrogen (BUN), lactic acid dehydrogenase (LDH), malonaldehyde (MDA) and muscle glycogen and hepatic glycogen etc. behind the residue rat swimming with a load attached to the body 90min.The result: the yellow the kidney invigorating of desert can prolong rats power exhaust swimming time, reduces the accumulation of lactic acid in serum and the skeletal muscle, the content of LDH and BUN in the reduction serum, and the content that reduces serum and skeletal muscle MDA.The yellow the kidney invigorating high dose group of desert significantly reduces serum lactic acid and LDH than the yellow the kidney invigorating low dose group of desert, and can significantly increase the glycogen deposit.Conclusion: the time that the yellow the kidney invigorating extract of desert can exhaust by the removing prolong rats power of accelerating metabolite and oxygen-derived free radicals, and be dose dependent.
Embodiment 7: this preparation uses case
Chen, 316 years old, height: 1.65; Body weight: 76kg; The company clerk.Because of task pressure, in the recent period later six months sexual impotence appears, with the soreness of waist, endurance not; Take preparation of the present invention every day 2 ~ 3 times, each 4.After January, erection angle, time, hardness are all satisfied, and it is normal, energetic that sexual life recovers.
Claims (3)
1, a kind of antifatigue Chinese medicine preparation is characterized in that: adopt following raw material to make: Herba Cistanches, Radix Rehmanniae Preparata, Semen Cuscutae, wine Fructus Schisandrae Chinensis (steamed), make with pharmaceutically acceptable method and adjuvant.
2, Chinese medicine according to claim 1 is characterized in that: Herba Cistanches, Radix Rehmanniae Preparata, Semen Cuscutae are 1: 1: 1 by the medical material weight proportion.
3, Chinese medicine according to claim 2 is characterized in that: per each medical material weight of amount of taking for 1000 times adopts following proportioning: Herba Cistanches, Radix Rehmanniae Preparata, Semen Cuscutae, wine Fructus Schisandrae Chinensis (steamed) are 1004.8g by the medical material weight proportion: 1004.8: 1004.8: 16.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101516327A CN101579439A (en) | 2009-06-30 | 2009-06-30 | Antifatigue traditional Chinese medicine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101516327A CN101579439A (en) | 2009-06-30 | 2009-06-30 | Antifatigue traditional Chinese medicine preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101579439A true CN101579439A (en) | 2009-11-18 |
Family
ID=41361844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009101516327A Pending CN101579439A (en) | 2009-06-30 | 2009-06-30 | Antifatigue traditional Chinese medicine preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101579439A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104593194A (en) * | 2015-02-09 | 2015-05-06 | 曾盛钊 | Mulberry health rice wine and preparation method thereof |
-
2009
- 2009-06-30 CN CNA2009101516327A patent/CN101579439A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104593194A (en) * | 2015-02-09 | 2015-05-06 | 曾盛钊 | Mulberry health rice wine and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20091118 |