CN101574443B - Rehabilitation medication combination for curing addiction to morphine drugs and preparation method thereof - Google Patents
Rehabilitation medication combination for curing addiction to morphine drugs and preparation method thereof Download PDFInfo
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- CN101574443B CN101574443B CN 200910303553 CN200910303553A CN101574443B CN 101574443 B CN101574443 B CN 101574443B CN 200910303553 CN200910303553 CN 200910303553 CN 200910303553 A CN200910303553 A CN 200910303553A CN 101574443 B CN101574443 B CN 101574443B
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Abstract
The invention relates to a rehabilitation medication combination for curing addition to morphine drugs and a preparation method thereof. The medication combination is prepared from the following raw drugs by weight percentage: 22% to 30% of pine needle juice, 22% to 30% of rhizome corydalis, 3% to 11% of hyoscyamus niger, 22% to 30% of radix jasmine sambac and 9% to 18% of amber. The invention provides a rehabilitation medication combination for curing addition to morphine drugs and a preparation method thereof, having the advantages of low toxic and side effects and good de-addiction effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating drug addiction, relate in particular to a kind of pharmaceutical composition that is used to treat drugs such as morphine addiction drug rehabilitation and detoxification and preparation method thereof.
Background technology
Be addicted to drug and wreak havoc the whole world as pestilence, none escapes by luck the five continents of human living.In the crowd of many countries, popular causing disaster.Spirit is wrecked in drug abuse, and the infringement human body corrodes soul, and causes addicts's collapse of the economy, family break-up, and prostitution, major crimes incidents such as violence are plundered in the theft of deriving inevitably then.In the addicts, more than 80% criminal offence arranged, influence social security, in China, the drug abuse illegal activity also is on the rise.At present, the drug rehabilitation and detoxification common drug of treatment drugs such as morphine addiction has methadone, and dihydro suffers holder coffee (DHE) and has been used for drug rehabilitation and detoxification, but there is following shortcoming in this quasi drugs:
1, methadone is used for drug rehabilitation and detoxification, and its mode is a treating the poisonous disease with poisonous drugs, with the alternative medicine of addiction for addiction, is its major defect because of methadone itself can produce addiction property, and can causes biliary tract pain, dyspepsia, excessive sweating, untoward reaction such as constipation;
2, dihydro suffers and asks coffee (DHE) to be used for the drug rehabilitation and detoxification medicine as substituting medicine, because psychic dependence is obvious, the sense of euphoria is arranged after the application, and the behavior of tangible rope medicine is arranged after the drug withdrawal; Occurred serious DHE abuse phenomenon in the society, profiteering is stolen and is used; Theft DHE, situation is serious, so unsuitable as the drug rehabilitation application.
3, the traditional Chinese medical science drug rehabilitation of introducing in the drug rehabilitation prescription commonly used is the side specially; For example all add clear prepared opium paste (opium semifinished product) in the prescriptions such as " add flavor king reinforcing the heart drug rehabilitation side ", " adding distinguishes the flavor of manage in drug rehabilitation side "; This drug rehabilitation mode is to realize drug rehabilitation and detoxification through the opium diminishing method; Its shortcoming also is a treating the poisonous disease with poisonous drugs, with addiction for addiction.
Summary of the invention
In order to solve the above-mentioned technical problem that exists in the background technology, what the invention provides that a kind of toxic and side effects is little, detoxification efficiency is good is used to pharmaceutical composition of treating drugs such as morphine addiction drug rehabilitation and detoxification and preparation method thereof.
Technical solution of the present invention is: the invention provides a kind of pharmaceutical composition that is used to treat the drug rehabilitation and detoxification of drugs such as morphine addiction, its special character is: said pharmaceutical composition is that the crude drug of 22-30% Folium Pini juice, 22-30% Rhizoma Corydalis, 3-11% Semen Hyoscyami, 22-30% Radix Jasmini Sambac and 9-18% succinum is prepared from percentage by weight.
Aforementioned pharmaceutical compositions is that the crude drug of 22-30% Folium Pini juice, 22-30% Rhizoma Corydalis, 3-11% Semen Hyoscyami, 22-30% Radix Jasmini Sambac, 9-18% succinum and 0.3-1.1% Borneolum Syntheticum is prepared from percentage by weight.
Aforementioned pharmaceutical compositions is that the drug rehabilitation and detoxification Shenque of external pastes (sublimed preparation of ointment or external).
A kind of preparation of drug combination method that is used to treat the drug rehabilitation and detoxification of drugs such as morphine addiction, its special character is: this method may further comprise the steps:
1) with Folium Pini, Rhizoma Corydalis, Semen Hyoscyami, Radix Jasmini Sambac, succinum cleans respectively, removes impurity, and is subsequent use;
2) get bright Folium Pini chopping, squeeze the juice, filter, subsequent use;
3) get succinum and pulverize, cross 600 mesh sieves, subsequent use;
4) get Rhizoma Corydalis, Semen Hyoscyami, the Radix Jasmini Sambac decocte with water adds 6 times of decoctings for the first time and boiled 2 hours, filters, and adds 4 times of decoctings for the second time and boils 1 hour, filters, and secondary filtrating merges, concentrating under reduced pressure, drying is ground into fine powder;
5) Borneolum Syntheticum is subsequent use with an amount of 95% dissolve with ethanol;
6) above-mentioned Chinese medicine fine powder and extract fine powder mixing add Borneolum Syntheticum alcoholic solution mixing, add Folium Pini juice mixing to the ointment shape, packing, packing, warehouse-in.
The present invention be according to the traditional Chinese medical science about accumulateing in the junkie tobacco poisoning, QI and blood Feng liquid is impaired, the internal organs imbalance of YIN and YANG, QI and blood is retarded by silt; The mechanism of qi operation is not normal, causes vigour to be exhausted, all rationale of decreasing of internal organs instruct down, from dispeling tobacco poisoning; Tranquilizing mind, promoting blood circulation and stopping pain is transferred smooth QI and blood, nourishing YIN and benefiting blood; Regulate the flow of vital energy with in a large amount of Chinese herbal medicine in the Folium Pini that screens, Rhizoma Corydalis, Semen Hyoscyami, Radix Jasmini Sambac; Succinum, Borneolum Syntheticum, through the drug rehabilitation and detoxification externally-applied medicinal composition that perfect technological process is rationally produced, it has the following advantages:
1. the treatment of the drug rehabilitation and detoxification of drugs such as morphine addiction and detoxification and addiction-removing is followed the traditional Chinese medical science and is cured the disease and stress the whole machine balancing of health, and organic conception is taked drug rehabilitation and detoxification and detoxification and addiction-removing unification to execute and controlled; It has can detoxification, again can withdrawal, and control is reverted to take drugs; The raw materials used medicine of the present invention simultaneously is natural drug, human body is not had injury, no toleration; No dependence, addiction not, advantage such as the little and detoxification efficiency of toxic and side effects is good.
2. the SHENQUE acupoint medication can be brought into play the dual function at medicine and acupuncture point.SHENQUE acupoint drug for point provided by the present invention has the following advantages:
1. SHENQUE acupoint links to each other with the human body twelve regular channels, and the vital organs of the human body communicate, and is human qi and blood running's passage, and in the SHENQUE acupoint medication, medicine can be absorbed into blood very soon, participates in blood circulation directly, brings into play its therapeutic efficiency.
2. the destruction of gastric acid to medicine has been avoided in SHENQUE acupoint medication, has avoided the first pass effect of liver, has avoided medicine to the gastrointestinal untoward reaction.
No matter 3. medicine is an oral administration, or drug administration by injection, all exists oral back or injection back blood concentration to raise very soon and peak; Along with metabolism; Blood drug level drops to low ebb gradually, when blood drug level reaches the peak, inevitably produces toxic and side effects; When blood drug level reaches low ebb, can not show curative effect.The SHENQUE acupoint medication absorbs and stablizes, and blood drug level is stable, the deficiency of weak curative effect when toxic and side effects when having avoided drug administration by injection or oral administration blood drug level peak and blood drug level low ebb.
4. SHENQUE acupoint is smart with medicine composition, and dosage is little, is 1/5 to 1/10 of oral administration, and drug cost is low.And can practice thrift a large amount of medical materials.
The specific embodiment
The present invention accumulates in the junkie drugs, and QI and blood Feng liquid is impaired, the internal organs imbalance of YIN and YANG, and QI and blood is retarded by silt, and the mechanism of qi operation is not normal, causes vigour to be exhausted, all pathogenesis that decreases of internal organs.And with nourishing vigour, strengthening vital QI to eliminate pathogenic factors, tranquilizing mind, promoting blood circulation and stopping pain is transferred smooth QI and blood, nourishing YIN and benefiting blood, regulate the flow of vital energy with in method of treatment, thereby reach the purpose of drug rehabilitation and detoxification, its compound basis:
1, Folium Pini
" Mingyi Bielu ": " blood circulation promoting and blood stasis dispelling is controlled traumatic injury "
" book on Chinese herbal medicine is through collection ": " mind calming is refreshing, and settling five organs is controlled insomnia, piliation.”
" book on Chinese herbal medicine converges and says ": " Folium Pini one thing also for Folium Pini, Folium Pini.Its bright leaf is smash juice and is made ball, and expelling wind and removing dampness is controlled the severe and migratory arthralgia muscular soreness, wind syndrome of head headache, as the utmost point person that itches, and the utmost point of using is imitated." Folium Pini has blood circulation promoting and blood stasis dispelling, mind tranquilizing and the heart calming, expelling wind and removing dampness itching-relieving efficacies.Cure for insomnia, the severe and migratory arthralgia muscular soreness, the whole body utmost point is itched.Among the people evident in efficacy, with a long history with the drug rehabilitation of Folium Pini juice.
2, Rhizoma Corydalis
" Compendium of Materia Medica. roll up 13. Rhizoma Corydalis " " stagnation of QI in can promoting the circulation of blood, stasis in the gas is so specially control all up and down all over the body pains, simply fantastic among using.”
" book on Chinese herbal medicine is looked for the truth ": " Rhizoma Corydalis no matter be that blood is gas, amasss and the person that do not loose, and obeys this power can lead to, and is warm in nature with it, and then can manage it in QI and blood can be smooth, and acrid in the mouth then can moisten and can loose in QI and blood, so all up and down pains of reason the whole body, the merit of often walking alone is many.”
Rhizoma Corydalis has blood-activating and qi-promoting, and the analgesia effect is among the people with corydalis tuber for treating heroin addiction definite effect.The structure of Rhizoma Corydalis ingredient and opiates have approximate part, to the opium vicarious function of reporting to the leadship after accomplishing a task, but do not have addiction property.
3, Semen Hyoscyami
" Mingyi Bielu ": " spasmolytic is decided will, and dry blast epilepsy is put upside down the Chinese holly contraction.Mad by frightened great fear, the disease being located in the heart spleen envelope, with spirit depressing, apathetic expression, being reticent and dementia, unconnected phrase.Or excited with spirit, manic just sudden and violent, rather do not stir up a disturbance, ruin thing and curse and beat, moving and many anger are characteristic, control and end the capital with Semen Hyoscyami and decide will.”
And promoting the circulation of QI to relieve pain are arranged, expelling cold and freeing bi, dampness removing to stop itchin effect, drug rehabilitation, the control withdrawal symptom definite effect of being used among the people.
Above Folium Pini, Rhizoma Corydalis, Semen Hyoscyami are used for drug rehabilitation, and the control withdrawal symptom is as monarch drug.
4, Radix Jasmini Sambac
Compendium of Material Medica: " promoting blood circulation and stopping pain, treatment are fallen damage muscles and bones, knife injury pain.
" book on Chinese herbal medicine compilation ": " all damages of falling, joint dislocation bone setter uses this, does not then know pain.”
" Sichuan Chinese medicinal herbal ": clearing away heart-fire for tranquillization, Cure for insomnia, the dreaminess of sleeping night, nervous breathing hard.
Radix Jasmini Sambac has promoting blood circulation and stopping pain clearing away heart-fire for tranquillization effect.Be used for analgesia, the Cure for insomnia definite effect.As ministerial drug.
5, succinum
" Mingyi Bielu ": settling five organs, decide soul, treatment cardiopalmus, insomnia, effective.
" Japan hanako materia medica ": the tool blood circulation promoting and blood stasis dispelling, should control stagnation of blood stasis, QI-blood circulation is not smooth.
" Compendium of Materia Medica. roll up 37. succinum ": inducing diuresis for treating stranguria syndrome.
Above-mentioned Radix Jasmini Sambac is used for analgesia, and the succinum tranquilizing mind is as adjuvant drug.
6, Borneolum Syntheticum
The gas of " Bencao Jingshu " fragrance can be warded off all evilnesses, hot property, and right all rheumatism of ability are so main trusted subordinate's pathogen and rheumatism are gathered also.
" Compendium of Materia Medica. roll up 14, Borneolum Syntheticum ": logical all keys, the stagnated fire of loosing.The have one's ideas straightened out effect of refreshment of Borneolum Syntheticum, tool, these article can promote drug absorption, improve blood drug level, and can promote the blood brain barrier effect, as messenger drug.
Above monarch, minister, assistant makes compatibility of drugs, and tobacco poisoning is dispeled in common performance, tranquilizing mind, the effect of promoting blood circulation and stopping pain solves the withdrawal symptom of removing tobacco poisoning and drug rehabilitation emphatically.
Therefore; The invention provides a kind of pharmaceutical composition that is used to treat drugs such as morphine addiction drug rehabilitation and detoxification, this pharmaceutical composition is comprising that percentage by weight is that the crude drug of 22-30% Folium Pini juice, 22-30% Rhizoma Corydalis, 3-11% Semen Hyoscyami, 22-30% Radix Jasmini Sambac and 9-18% succinum and 0.3-1.1% Borneolum Syntheticum is prepared from.
Below be concrete proportioning instance of the present invention (is unit with the percentage by weight):
The present invention also provides a kind of preparation of drug combination method that is used to treat drugs such as morphine addiction drug rehabilitation and detoxification when being provided for treating the pharmaceutical composition of drugs such as morphine addiction drug rehabilitation and detoxification, this method may further comprise the steps:
1, with Folium Pini, Rhizoma Corydalis, Semen Hyoscyami, Radix Jasmini Sambac, succinum cleans respectively, removes impurity, and is subsequent use;
2, get bright Folium Pini chopping, squeeze the juice, filter, subsequent use;
3, get succinum and pulverize, cross 600 mesh sieves, subsequent use;
4, get Rhizoma Corydalis, Semen Hyoscyami, the Radix Jasmini Sambac decocte with water adds 6 times of decoctings for the first time and boiled 2 hours, filters, and adds 4 times of decoctings for the second time and boils 1 hour, filters, and secondary filtrating merges, concentrating under reduced pressure, drying is ground into fine powder;
5, Borneolum Syntheticum is subsequent use with an amount of 95% dissolve with ethanol;
6, above-mentioned Chinese medicine fine powder and extract fine powder mixing add Borneolum Syntheticum alcoholic solution mixing, add Folium Pini juice mixing to the ointment shape, packing, packing, warehouse-in.
For the ease of explanation, clinical comparison experimental result of the present invention is following:
To the drugs such as morphine addict,, divide three groups of observe the curative effect following with every group 160 example:
Embodiment one: matched group is a matched group with the JIAWEI TIANWANG BUXIN JIEDU FANGJI, obeys 2-4g, every day 3 times at every turn; After the medication 11 days, withdrawal symptom disappears, drugs negative patient 93 examples in the detection bodies; Withdrawal symptom obviously alleviates, positive person's 12 examples a little less than the drugs in the detection bodies, invalid 55 examples.
Embodiment two: the treatment group, and each external drug rehabilitation and detoxification god faints and pastes 1-2g, and every day 1 time (is equivalent to crude drug: Folium Pini juice 0.5-1.0g, Rhizoma Corydalis 0.5-1.0g; Semen Hyoscyami 0.15-0.3g, Radix Jasmini Sambac 0.5-1.0g, succinum 0.25-0.5g); After the medication 11 days, withdrawal symptom disappears, drugs negative patient 141 examples in the detection bodies; Withdrawal symptom obviously alleviates, positive person's 9 examples a little less than the drugs in the detection bodies, invalid 10 examples.
Embodiment three: the treatment group, and each external drug rehabilitation and detoxification god faints and pastes 1-2g, and every day 1 time (is equivalent to crude drug: Folium Pini juice 0.5-1.0g, Rhizoma Corydalis 0.5-1.0g; Semen Hyoscyami 0.15-0.3g, Radix Jasmini Sambac 0.5-1.0g, succinum 0.25-0.5g); Borneolum Syntheticum 15-30mg), medication is the withdrawal symptom disappearance after 11 days, drugs negative patient 149 examples in the detection bodies; Withdrawal symptom obviously alleviates, and positive person's 11 examples a little less than the drugs in the detection bodies are to the case of this 11 routine refractory; After then continuing medication 3-5 days, the only remaining 3 examples slight withdrawal symptom that happens occasionally continues with this medicine treatment.
Claims (4)
1. pharmaceutical composition that is used to treat the drug rehabilitation and detoxification of drugs such as morphine addiction is characterized in that: said pharmaceutical composition is that the crude drug of 22-30% Folium Pini juice, 22-30% Rhizoma Corydalis, 3-11% Semen Hyoscyami, 22-30% Radix Jasmini Sambac and 9-18% succinum is prepared from percentage by weight; The said application method that is used for the pharmaceutical composition of drugs such as morphine addiction drug rehabilitation and detoxification is the SHENQUE acupoint medication.
2. the pharmaceutical composition that is used to treat the drug rehabilitation and detoxification of drugs such as morphine addiction according to claim 1 is characterized in that: said pharmaceutical composition is that the crude drug of 22-30% Folium Pini juice, 22-30% Rhizoma Corydalis, 3-11% Semen Hyoscyami, 22-30% Radix Jasmini Sambac, 9-18% succinum and 0.3-1.1% Borneolum Syntheticum is prepared from percentage by weight.
3. the pharmaceutical composition that is used to treat the drug rehabilitation and detoxification of drugs such as morphine addiction according to claim 1 and 2, it is characterized in that: said pharmaceutical composition is the sublimed preparation of external.
4. the described preparation of drug combination method that is used to treat the drug rehabilitation and detoxification of drugs such as morphine addiction of a claim 2, it is characterized in that: this method may further comprise the steps:
1) with Folium Pini, Rhizoma Corydalis, Semen Hyoscyami, Radix Jasmini Sambac, succinum cleans respectively, removes impurity, and is subsequent use;
2) get bright Folium Pini chopping, squeeze the juice, filter, subsequent use;
3) get succinum and pulverize, cross 600 mesh sieves, subsequent use;
4) get Rhizoma Corydalis, Semen Hyoscyami, the Radix Jasmini Sambac decocte with water adds 6 times of decoctings for the first time and boiled 2 hours, filters, and adds 4 times of decoctings for the second time and boils 1 hour, filters, and secondary filtrating merges, concentrating under reduced pressure, drying is ground into fine powder;
5) Borneolum Syntheticum is subsequent use with an amount of 95% dissolve with ethanol;
6) above-mentioned Chinese medicine fine powder and extract fine powder mixing add Borneolum Syntheticum alcoholic solution mixing, add Folium Pini juice mixing to the ointment shape, packing, packing, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910303553 CN101574443B (en) | 2009-06-23 | 2009-06-23 | Rehabilitation medication combination for curing addiction to morphine drugs and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910303553 CN101574443B (en) | 2009-06-23 | 2009-06-23 | Rehabilitation medication combination for curing addiction to morphine drugs and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101574443A CN101574443A (en) | 2009-11-11 |
| CN101574443B true CN101574443B (en) | 2012-05-02 |
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| CN 200910303553 Expired - Fee Related CN101574443B (en) | 2009-06-23 | 2009-06-23 | Rehabilitation medication combination for curing addiction to morphine drugs and preparation method thereof |
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