CN101565459A - Streptococcus pneumoniae proteins and nucleic acid molecules - Google Patents

Abstract

Novel protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.

Description

Streptococcus pneumoniae proteins and nucleic acid molecule

The application be that July 27, application number in 1999 are 99811015.9 the applying date, denomination of invention divides an application for the application for a patent for invention of " streptococcus pneumoniae proteins and nucleic acid molecule ".

The present invention relates to be derived from the protein of streptococcus pneumoniae (Streptococcus pneumoniae), this proteinic nucleic acid molecule of encoding, this nucleic acid and/or protein are as antigen/immunogenic purposes and the purposes in detection/diagnosis, and screening is as the method for the protein/nucleotide sequence of potential resisting-microorganism target.

Streptococcus pneumoniae often is called as streptococcus pneumoniae, and it is a kind of important pathogenic microorganism.In developing country and developed country, streptococcus pneumoniae infection occupies critical role all the time in human diseases, and the relevant expert had carried out commentary (Fiber, G.R., science, 265:1385-1387 (1994)) to this.It is believed that worldwide this microorganism is the modal pathogenic bacterium of acute respiratory infection, estimate to cause 100 ten thousand death of child every year, great majority wherein are the children (Stansfield of developing country, S.K., paediatrics transmissible disease, 6:622 (1987)).In the U.S., the someone proposes (Breiman etc., Arch.Intern.Med., 150:1401 (1990)) streptococcus pneumoniae is still the modal pathogenic bacterium of bacterial pneumonia, children, and the elderly and suffer from the easy infection disease, as alienia disease, heart trouble, tuberculosis and ephrosis, diabetes, crapulent patient, or suffering from immunosuppressant disease, among the patient as AIDS, the sickness rate of bacterial pneumonia is high especially.Therefore suffer from an inflammation of the lungs coccus septicemia and (suffer from) meningitic risk of these crowds is higher, the risk that the coccus that therefore dies of pneumonia infects is bigger.Streptococcus pneumoniae also is the pathogenic bacterium of otitis media and sinusitis paranasal sinusitis, and these two kinds of diseases are popular infection always in the children of developed country, and bring very big cost.

Recently, the pneumococcal appearance of penicillin-resistance makes to the needs of the strategy of effective prevention pneumococcal infection urgent day by day.It is reported, in the 13 tame hospitals in 12 states of the U.S., 6.6% streptococcus pneumoniae strain isolated has resistance to penicillin, some strain isolateds are also to other microbiotic, comprise that third generation S-Neoral has resistance (Schappert, S.M., the population and the healthy state statistic data at national Centre for Disease Control/healthy state statistics center, 214:1 (1992)).In some hospital, the ratio of penicillin resistance higher (reaching 20%) (Breiman etc., American Medical Association's will, 271:1831 (1994)).Because pneumococcal penicillin resistance is to keep better curative effect after decades at penicillin, and is emergent in the recent period, so these discoveries make us panic.

In view of above-mentioned reason, must be devoted to the improvement prevention, control, the method for diagnosis or treatment streptococcus pneumoniae disease.

Adopted several different methods to provide the prevention pneumococcal infection used vaccine.It can be divided into different serotype (at least 90 kinds) according to the polysaccharide pod membrane structure around the microorganism, produce a plurality of difficult problems thus.Vaccine at single serotype is invalid to other serotype, this means that vaccine must comprise that the polysaccharide antigen of all serotypes could be in most of the cases effective.Someone finds (determining serotype separately when capsular polysaccharide; and be main protective antigen) be purified and when the vaccine; can not in the children's body below two years old, induce protection antibody to reply reliably, and this age group invasive pneumococcal infection and the highest crowd of meningitic sickness rate exactly.

Use the improvement of kantigen method to rely on polysaccharide and proteinic puting together, thereby reply the feature that depends on the T-cell and obtain the enhanced immunne response by giving especially.This method has been used to develop for example vaccine of anti influenza influenzae (Haemophilus influenzae).Yet, be still bone of contention about multiple polysaccharide vaccine with based on the cost of the vaccine of conjugate.

The third method is to seek other to have the antigen component of the potentiality that become candidate vaccine.In the present invention, we provide a histone matter antigen, and described antigen is secretion/output protein.

Therefore, first aspect the invention provides streptococcus pneumoniae proteins or polypeptide, and it has and is selected from the sequence shown in the table 2.

Protein of the present invention that is provided or polypeptide can be pure basically forms.For example, can be to be substantially free of other proteinic form.

In preferred embodiments, provide protein or polypeptide with aminoacid sequence shown in the table 3.

The present invention includes any protein by nucleic acid sequence encoding shown in this paper table 1.

As described herein, protein of the present invention and polypeptide can be used as antigenic substance.Described material can be " antigenic " and/or " immunogenic ".Usually, " antigenic " is meant that in fact protein or polypeptide can be used to produce antibody, perhaps can induce antibody response in subject." immunogenic " is meant that protein or polypeptide can cause protective immune response in subject.Therefore, under latter event, protein or polypeptide can not only produce antibody response, can also produce not the immunne response based on antibody.

Those skilled in the art should understand that the homologue of protein of the present invention or polypeptide or derivative also can be used for context of the present invention, promptly as antigenic/immunogenic material.Therefore, the present invention also comprises for example having one or more interpolations, disappearance, the protein or the polypeptide of replacement etc.In addition, can be with the amino acid of a kind of aminoacid replacement another kind similar " type ".For example, replace another kind of hydrophobic amino acid with a kind of hydrophobic amino acid.Can service routine (as the CLUSTAL program) comparing amino acid sequence.This program can compare aminoacid sequence, and inserts in arbitrary sequence when suitable and find the optimal sequence contrast at interval.Can correlated amino acid identity of calculating optimum sequence or similarity (identity adds the conservative property of amino acid type).Can contrast one section the longest similar sequences and specify such as the program of BLASTx and meet value.Therefore, can obtain comparative result, can find several similaritys zone therein, they have different score values separately.The present invention wishes to carry out this analysis of two types.

For homologue and derivative, more inessential with the identity degree of protein described herein or polypeptide, importantly homologue or derivative should keep antigenicity or the immunogenicity of streptococcus pneumoniae.Yet, provide that to have the homologue or a derivative (as discussed above) of at least 60% similarity comparatively suitable with protein described herein or polypeptide, homologue or derivative with at least 70% similarity preferably are provided, homologue or derivative with at least 80% similarity more preferably are provided, most preferably provide to have at least 90% or even the homologue or the derivative of 95% similarity.

In another approach, homologue or derivative can be fusion roteins, and the moiety of wherein mixing is by for example mark desired protein or polypeptide make purifying become easier effectively.Must remove " marker ", perhaps, in fact fusion rotein self should keep enough antigenicities so that it is useful.

In another aspect of this invention, provide protein of the present invention or polypeptide, or the antigenicity/immunogenic fragments of its homologue or derivative.

With regard to protein described herein or polypeptide, or the fragment of its homologue or derivative, situation is slightly different.As everyone knows, can screen antigen protein or polypeptide, promptly be responsible for the antigenicity or the immunogenic zone of protein or polypeptide to identify epitope regions.It is well-known in the art carrying out this method for screening, and therefore, fragment of the present invention should comprise one or more described epitope regions, perhaps enough similar to keep its antigenicity/immunogenicity to described zone.Therefore, for fragment of the present invention, the identity degree may be incoherent because they can with protein as herein described or polypeptide, the specific part 100% of homologue or derivative is identical.Equally, main problem is that fragment must keep antigenicity/immunogenicity.

Therefore, for the homologue of deriving and obtaining by protein or polypeptide, derivative and fragment, importantly they should have its derived from described protein or the incomplete antigen/immunogenicity at least of polypeptide.

Can use gene clone technology that pure basically protein of the present invention is provided.Described technology is disclosed in for example Sambrook etc., molecular cloning, the 2nd edition, press of cold spring harbor laboratory (1989).Therefore, fourth aspect the invention provides nucleic acid molecule, and it contains following sequence or is made up of following sequence:

(i) any dna sequence dna shown in the table 1 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) the coding schedule 1 proteinic homologue that limits, derivative or fragments sequence.

The 5th aspect the invention provides nucleic acid molecule, and it contains following sequence or is made up of following sequence:

(i) any dna sequence dna shown in the table 4 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) the coding schedule 4 proteinic homologue that limits, derivative or fragments sequence.

Nucleic acid molecule of the present invention comprises a plurality of this sequences and/or fragment.Those skilled in the art should understand the neomorph that the present invention includes the new specific nucleic acid molecule that this paper exemplifies.The present invention includes this variant.Described variant can be natural variant, for example the variant that produces owing to the bacterial strain variation.For example, comprise interpolation, replace and/or disappearance.In addition, particularly when using the microbial expression system, people wish by utilizing the codon of expressing known preference use in the used specific organism to transform nucleotide sequence.Therefore, also comprise synthetic or non--natural variant in the scope of the present invention.

Sequence that the given RNA molecule of above used term " RNA equivalent " expression has and the sequence complementation of given dna molecular (allowing in the RNA genetic code, to substitute " T ") with " U ".

When relatively nucleotide sequence is with mensuration homology or identity degree, for example can use relatively two sequences of BESTFIT and GAP (all deriving from Wisconsin Genetics Computer Group (GCG) software package) BESTFIT program, produce the optimal sequence contrast of similar section.GAP can make sequence compare along its total length, and inserts in arbitrary sequence when suitable and find the optimal sequence contrast at interval.In the context of the present invention, when the identity of nucleotide sequence is discussed, be suitable for by carrying out sequence along full length sequence to comparative sequences recently.

Preferred substantially the same sequence and described sequence has at least 50% sequence identity, more preferably has at least 75% sequence identity, more preferably has at least 90% or at least 95% sequence identity.In some cases, sequence identity can be 99% or more than.

Preferably, term " substantially the same " expression: for the identity degree of the nucleotide sequence of described sequence and prior art, the identity degree of described sequence and arbitrary sequence described herein is higher.

Yet, should be noted that when nucleic acid sequence encoding of the present invention during to the new gene product of small part, comprise all possible sequence of encoding gene product or its new part in the scope of the invention.

Nucleic acid molecule can be the form of isolating form or reorganization.It can be mixed carrier, carrier can be impregnated in the host.Described carrier and suitable host constitute another aspect of the present invention.

Therefore, for example,, can identify the gene of streptococcus pneumoniae by using probe based on the nucleotide sequence that this paper provided.Use Restriction Enzyme can downcut these genes, be cloned into carrier, again carrier is imported suitable host to express.

By the partial sequence complementary suitable probe of use, can from streptococcus pneumoniae, obtain nucleic acid molecule of the present invention with nucleic acid molecule.Can use Restriction Enzyme or supersound process technology to obtain suitably big or small fragment to be used as probe.

Perhaps, can use the required nucleotide sequence of round pcr amplification.Therefore, can use two primers of sequence data design provided herein to be used for PCR, thereby make required sequence, comprise that complete genome or its fragment by target, are increased immediately high-levelly.Under the normal circumstances, a primer has high-caliber specificity to first sequence on the chain that is positioned at dna molecular, another primer has high-caliber specificity to second sequence that is positioned on the dna sequence dna complementary strand, the complementary sequence of described second sequence and first sequence segment distance of being separated by.

It is long that primer generally is at least 15 to 25 Nucleotide.

Another kind method is to use chemosynthesis, and this method can be carried out automatization.Can chemosynthesis relatively short sequence, be interconnected to form long sequence again.

On the other hand, the invention provides immunogenicity/antigenic composition, said composition contains one or more and has protein or polypeptide or its homologue or the derivative of sequence that is selected from sequence shown in the table 2-4, and/or any the fragment in them.In preferred embodiments, immunogenicity/antigenic composition is a vaccine, perhaps can be used for diagnostic test.

With regard to vaccine, it can comprise the vehicle of suitable interpolation, thinner, adjuvant etc.A plurality of specific exampless are well-known in the art.

Nucleotide sequence shown in also can use table 1 prepares so-called dna vaccination.Therefore, the present invention also provides the vaccine composition that contains one or more nucleotide sequences defined herein.Existing people described the purposes of this dna vaccination in this area, and example is seen Donnelly etc., and 15:617-648 (1997) is commented in immunity academic year.

As mentioned above, in the method for detection/diagnosis streptococcus pneumoniae, can use protein as herein described or polypeptide, its homologue or derivative, and/or any the fragment in them.Detect the anti-described proteinic antibody that exists in the subject, set up aforesaid method based on this.Therefore, the invention provides the method for detection/diagnosis streptococcus pneumoniae, described method comprises makes given the test agent and at least a protein as herein described or its homologue, the step of derivative or fragment contact.Preferred sample is a biological sample, as derives from experimenter's to be measured tissue sample or blood sample or saliva.

In another approach, can use protein as herein described, or its homologue, derivative and/or fragment produce antibody, and conversely, described antibody can be used for detecting antigen, thereby can detect streptococcus pneumoniae.Described antibody constitutes another aspect of the present invention.Antibody in the scope of the invention can be mono-clonal or polyclonal antibody.

When with protein as herein described, or its homologue, when derivative or fragment are injected in suitable animal host (as mouse, rat, cavy, rabbit, sheep, goat or the monkey) body, can make animal produce polyclonal antibody by stimulating antibody to generate.In case of necessity, can use adjuvant and protein simultaneously.Well-known adjuvant comprises freund's adjuvant (complete and Freund) and aluminium hydroxide.Then, utilize antibody and combination of proteins described herein to get final product antibody purification.

Monoclonal antibody can be produced by hybridoma.Can form hybridoma by the splenocyte that merges myeloma cell and the required antibody of generation with the clone that forms infinite multiplication.Therefore, can use well-known Kohler ﹠amp; Milstein technology (nature, 256 (1975)) or the technology of on the basis of this technology, changing.

At present, production has been the mature technology of this area with the technology of specific polypeptides bonded mono-clonal and polyclonal antibody.Relevant discussion can be referring to the immunology textbook of standard, Roitt etc. for example, immunology, the 2nd edition (1989), Churchill Livingstone, London.

Except complete antibody, the present invention also comprises the derivative of this antibody, and described derivative can combine with protein as described herein etc.Therefore, the present invention includes antibody fragment and synthetic construct.The example of antibody fragment and synthetic construct can be referring to Dougall etc., Tibtech 12372-379 (in September, 1994).

Antibody fragment comprises for example Fab, F (ab ') ₂With the Fv fragment.Fab fragment (these fragments are discussed in [document are the same] such as Roitt).Can modify the Fv fragment is known as strand Fv (scFv) molecule with generation synthetic construct.This molecule comprises and V _hAnd V _lDistinguish covalently bound peptide linker, it is contributed to some extent to the stability of molecule.Operable other synthetic construct comprises the CDR peptide, and they are to contain antigen-in conjunction with the synthetic peptide of determinant.Also can use simulating peptide, these molecules are the limited organic ring of conformation normally, and it can simulate the structure of CDR ring, and comprise can with the side chain of AI.

Synthetic construct comprises chimeric molecule.Therefore, for example, also comprise humanization (or primateization) antibody or derivatives thereof in the scope of the invention.The example of humanized antibody is the antibody with people's framework region and rodent hypervariable region.Producing the method for chimeric antibody can be referring to for example Morrison etc., PNAS, and 81,6851-6855 (1984) and Takeda etc., naturally, and 314,452-454 (1985).

Synthetic construct also comprises the molecule that contains other moiety, and described other composition can be molecule some desired characteristic except that the antigen binding characteristic are provided.For example, described moiety can be marker (for example fluorescence or a radio-labeling).Perhaps, also can be pharmaceutically active agents.

The antibody or derivatives thereof can be used for detection/diagnosis streptococcus pneumoniae.Therefore, on the other hand, the invention provides the method for detection/diagnosis streptococcus pneumoniae, described method comprises the step that given the test agent is contacted with antibody, described antibody capable is in conjunction with one or more protein as herein described, or its homologue, derivative and/or fragment.

In addition, can use so-called " affine body ".These affine bodies are conjugated protein (Nord etc.) that are selected from the combinatorial library of alpha-helix bacterial receptor structural domain.Therefore, can use the combinatorial library method select can with different target protein specificity bonded small protein matter structural domains.

Obviously, can use nucleotide sequence detection/diagnosis streptococcus pneumoniae as herein described.Therefore, on the other hand, the invention provides the method for detection/diagnosis streptococcus pneumoniae, described method comprises makes given the test agent contact with at least a nucleotide sequence as herein described.Preferred sample is a biological sample, as derives from experimenter's to be measured tissue sample or blood sample or saliva.Before being used for method of the present invention, can carry out pre-treatment to sample.Therefore, for example, can handle sample to extract DNA.Use the nucleic acid that detects streptococcus pneumoniae based on the dna probe of nucleotide sequence described herein (being generally the fragment of this sequence) then.

In others, the invention provides:

(a) the immunization experimenter is in case the method for streptococcus pneumoniae, and described method comprises to the experimenter uses protein of the present invention or polypeptide, or derivatives thereof, homologue or fragment, or the step of immunogenic composition of the present invention;

(b) the immunization experimenter is in case the method for streptococcus pneumoniae, and described method comprises the step of using nucleic acid molecule defined herein to the experimenter;

(c) method of prevention or treatment streptococcus pneumoniae infection, described method comprises to the experimenter uses protein of the present invention or polypeptide, or derivatives thereof, homologue or fragment, or the step of immunogenic composition of the present invention;

(d) method of prevention or treatment streptococcus pneumoniae infection, described method comprises the step of using nucleic acid molecule defined herein to the experimenter;

(e) be used to detect/diagnose the test kit of streptococcus pneumoniae infection, it comprises one or more protein of the present invention or polypeptide, or its homologue, derivative or fragment, or antigenic composition of the present invention; With

(f) be used to detect/diagnose the test kit of streptococcus pneumoniae infection, it comprises the nucleic acid molecule that one or more are defined herein.

Even we have identified one group of important protein matter, described protein is the potential target of antimicrobial therapy.Whether yet still must measure each protein is that microbial survival is necessary.Therefore whether still, the present invention also provides and has measured protein described herein or whether polypeptide is the method for the antimicrobial target of potential, and described method comprises the described protein of deactivation, and measure streptococcus pneumoniae survival in external or body.

Whether the proteinic proper method of deactivation is to carry out selected gene knockout, promptly stop protein expression and measure to cause lethality to change.The proper method that carries out described gene knockout is described in Li etc., institute of NAS newspaper, 94:13251-13256 (1997).

Last aspect, the invention provides can antagonism, suppress or otherwise disturb the medicament of the function of protein of the present invention or polypeptide or expression to be used to prepare the purposes of medicine, described medicine can be used for treatment or prevention streptococcus pneumoniae infection.

Describe the present invention hereinafter with reference to embodiment, embodiment should not regarded as and limit the present invention by any way.The accompanying drawing of reference is among the embodiment:

Fig. 1: the result who demonstrates multiple dna vaccination test; With

Fig. 2: the result who demonstrates other dna vaccination tests.

Embodiment 1

Just (TIGR, Rockville, MD, the U.S.) carries out the gene order-checking of 4 type streptococcus pneumoniaes at the genome research center.Up to the present, complete sequence remains unfulfilled or discloses.On November 21st, 1997, the TIGR center has discharged some dna sequence dnas with overlap group's form, and this can not accurately reflect completed sequence.Can from the network address (www@tigr.org) at TIGR center, download these overlaps group.We have downloaded these overlaps group, use application program GCGToBLAST (Wisconsin Package Version 9.1, Genetics Computer Group (GCG), Madison, the U.S.) to set up local data base.Available FastA and TfastA method are retrieved this database and (are used the method (institute of NAS newspaper, 85:2444-2448 (1988)) of Pearson and Lipman.

Use FastA and TfastA method, retrieve and infer leader sequence or anchor sequence signature in the local streptococcus pneumoniae database.Use correlated series inquiry (interrogate) newer sequence.They are:

(i) the streptococcus pneumoniae leader sequence of having described (deriving from protein N anA, NanB, LytA, PapA, pcpA, PsaA and PspA);

The (ii) leader sequence of Lactococcus lactis (Lactococcus lactis) secretary protein Usp45;

(iii) retrieval (i) and the (ii) new vacation plan leader sequence of gained;

The (iv) LPxTG of anchorage unit, it is the common trait of a lot of gram positive bacterium surface proteins, but this primitive by participating in the proteic mechanism anchor of Sortase complex body.

The example of this method is provided hereinafter with reference to the sequence that is derived from database (seeing Table I).

The proteinic protein leader sequence of different known output is used as the starting point of retrieving above-mentioned local streptococcus pneumoniae database.At general database,, among the Swissprot etc. the false albuminoid of finding by this retrieval is carried out the Blast retrieval then as EMBL.Reservation is also explained still unknown pneumoprotein matter.Use the TfastA method then, use new potential protein leader sequence to retrieve once more as probe.

Embodiment 2:DNA vaccine test

PcDNA3.1+ is as dna vaccine vector

pcDNA3.1+

Selected carrier as dna vaccine vector is pcDNA3.1 (Invitrogen) (is actually pcDNA3.1+, all use the forward carrier in all cases, but this paper is referred to as pcDNA3.1).In the literature, this carrier extensively and successfully has been used as host's carrier to detect the situation (Zhang etc., Kurar and Splitter, Anderson etc.) of vaccine candidate gene initiation at the pathogenic agent provide protection.This carrier is designed to carry out high level in mammalian cell stable and non--transient expression that duplicates.PcDNA3.1 contains the ColE1 replication orgin, duplicates and grows so that carry out high copy number in intestinal bacteria.Also can clone and detect a lot of genes fast and effectively conversely.The pcDNA3.1 carrier has a large amount of cloning sites, also contains the amicillin resistance encoding gene that helps clonal selection and the human cytomegalic inclusion disease virus of high level expression recombinant protein (CMV) immediate early promoter/enhanser effectively.In the various kinds of cell type that comprises myocyte and immunity (antigen presentation) cell, the CMV promotor is the strong virus promotor.This is most important for best immunne response, because do not know still that at present which kind of cell type is most important for producing protective response in vivo.The T7 promotor of multiple clone site upstream can make required modified inset effective expression, and can be at the external clone gene of transcribing on sense orientation.

Zhang, D., Yang, X., Berry, J.Shen, C., McClarty, G and Brunham, R.C. (1997), " carry out dna immunization with the major outer membrane protein gene and can induce the acquired immunity power that infects at chlamydia trachomatis (mouse pneumonia) ", infect and immunity, 176,1035-40.

Kurar, E and Splitter, G.A (1997), " nucleic acid immunization of Bacillus abortus rrna L7/L12 gene causes immunne response ", vaccine, 15,1851-57.

Ander, R., Gao, X.M., Papakonstantinopoulou, A., Roberts, M and Dougan, G (1996), " with the immunne response after the segmental dna immunization mouse of coding tetanus toxin C " infects and immunity, and 64,3168-3173.

The preparation dna vaccination

Be each the required gene design Oligonucleolide primers that uses the LEEP system to obtain.Overhaul each gene, if possible, should design primer and make its target it is believed that the only Gene Partial of the proteinic maturing part of encoding gene.We wish that when expressing those sequences of expressing the maturing part of the target gene protein matter of only encoding can help proteinic correct folding in mammalian cell.For example, in most of the cases, should design primer so that be cloned into the final amplified production of pcDNA3.1 expression vector and not contain the terminal signal peptide sequence of the N-that infers.Signal peptide via protein output pathway guiding cytolemma, downcuts signal peptide at this by signal peptidase I (if lipoprotein is signal peptidase I I) with polypeptide precursor.Therefore, no matter be presented on bacterium surface or secreted, signal peptide does not constitute arbitrary part of mature protein.When the terminal leader peptide sequences of N-when not being apparent immediately, should design primer with the whole gene order of target with clone in pcDNA3.1 and finally express.

Yet, said that proteinic further feature also can influence the expression of soluble protein and presents.In the process of design oligonucleotides, should in the gene of coding desired protein, get rid of the dna sequence dna of these features of coding.These features comprise:

1.LPXTG the cell walls anchor primitive.

2.LXXC lipoprotein binding site.

3. hydrophobic C-end structure territory.

4. when not having terminal signal peptide of N-or LXXC, should remove terminator codon.

5. when not having hydrophobicity C-end structure territory or LPXTG primitive, should remove terminator codon.

Be interested each gene design suitable substance P CR primer, when these primers of design, should from gene, remove any and All Ranges of the above-mentioned feature of coding.Primer is designed to have suitable Restriction Enzyme site, and then conservative thereafter Kozak nucleotide sequence, and that (in all cases) uses is GCCACC.The Kozak sequence helps eucaryon rrna identification homing sequence and is positioned at the ATG initiator codon of required gene inset upstream.For example, use the forward primer in BamHI site initial with GCGGGATCCGCCACCA TG, a bit of sequence of required gene 5 ' end is followed in the back.Design reverse primer with compatible with forward primer, and compatible with the NotI restriction site (this site is TTGCGGCCGC) of 5 ' end in all cases.

The PCR primer

Following PCR primer is designed to the required truncated gene that increases.

ID210

Forward primer 5 ' CGGATCCGCCACCATGTCTTCTAATGAATCTGCCGATG3 '

Reverse primer 5 ' TTGCGGCCGCCTGTTTAGATTGGATATCTGTAAAGACTT3 '

4172.5

Forward primer 5 '

CGCGGATCCGCCACCATGGATTTTCCTTCAAATTTGGAGG?3′

Reverse primer 5 ' TTGCGGCCGCACCGTACTGGCTGCTGACT 3 '

ID211

Forward primer 5 '

CGGATCCGCCACCATGAGTGAGATCAAAATTATTAACGC?3′

Reverse primer 5 ' TTGCGGCCGCCGTTCCATGGTTGACTCCT 3 '

4197.4

Forward primer 5 ' CGCGGATCCGCCACCATGTGGGACATATTGGTGGAAAC3 '

Reverse primer 5 ' TTGCGGCCGCTTCACTTGAGCAAACTGAATCC 3 '

4122.1

Forward primer 5 '

CGCGGATCCGCCACCATGTCACAAGAAAAAACAAAAAATGAA?3′

Reverse primer 5 ' TTGCGGCCGCATCGACGTAGTCTCCGCC 3 '

4126.7

Forward primer 5 '

CGCGGATCCGCCACCATGCTGGTTGGAACTTTCTACTATCAAT?3′

Reverse primer 5 ' TTGCGGCCGCAACTTTCGTCCCTTTTTGG 3 '

4188.11

Forward primer 5 ' CGCGGATCCGCCACCATGGGCAATTCTGGCGGAA 3 '

Reverse primer 5 ' TTGCGGCCGCTTGTTTCATAGCTTTTTTGATTGTT 3 '

ID209

Forward primer 5 '

CGCGGATCCGCCACCATGCTATTGATACGAAATGCAGGG?3′

Reverse primer 5 ' TTGCGGCCGCAACATAATCTAGTAAATAAGCGTAGCC 3 '

ID215

Forward primer 5 ' CGCGGATCCGCCACCATGACGGCGACGAATTTTC 3 '

Reverse primer 5 ' TTGCGGCCGCTTAATTCGTTTTTGAACTAGTTGCT 3 '

4170.4

Forward primer 5 '

CGCGGATCCGCCACCATGGCTGTTTTTCTTCGCTATCATG?3′

Reverse primer 5 ' TTGCGGCCGCTTTCTTCAACAAACCTTGTTCTTG 3 '

4193.1

Forward primer 5 '

CGCGGATCCGCCACCATGGGTAACCGCTCTTCTCGTAAC?3′

Reverse primer 5 ' TTGCGGCCGCGCTTCCATCAAGGATTTTAGC 3 '

The clone

Isolation of genomic DNA from the 4 type S. pneumoniae strains 11886 that derive from national typical culture collection center, as template through pcr amplification inset and flanking sequence with above-mentioned feature.With suitable Restriction Enzyme cutting PCR product, use conventional Protocols in Molecular Biology to be cloned into the multiple clone site of pcDNA3.1.Cultivate through the suitably required gene clone of mapping, the extensive separation quality grain of use Plasmid Mega test kit (Qiagen) (＞1.5mg).Carry out restriction map analysis and order-checking by about 700 base pairs, confirm that further the success of gene is cloned and kept 5 ' clone's joint of each extensive goods of each construct.

Bacterial strain confirms

Use 4 type bacterial strains in the method for clone and attack, the streptococcus pneumoniae genome of this bacterial strain is checked order.The homogeneous laboratory strains freeze-drying ampoule of 4 type S. pneumoniae strains 11886 derives from national typical DSMZ.Open ampoule, with 0.5ml tryptone beans peptone meat soups (0.5% glucose, 5% blood) suspension culture again.The culture suspension that goes down to posterity in 10ml tryptone beans peptone meat soup (0.5% glucose, 5% blood) is in 37 ℃ of static incubated overnight.This culture of line is rule on the blood agar inclined-plane to check pollutent and to confirm survival on 5% blood agar flat board, uses all the other cultures to prepare 20% glycerine original seed.Slant culture is delivered to the public health experimental center, and verified serotype is 4 types.

On 5% blood agar flat board the line NCTC11886 the glycerine original seed, in 37 ℃ at CO ₂Incubated overnight in the gas tank.Prepare fresh streak culture and confirm optochin susceptibility.

Streptococcus pneumoniae is attacked

Through go down to posterity streptococcus pneumoniae culture 1 time of mouse, from the blood of infection animal, collect streptococcus pneumoniae, in meat soup, be cultured to predetermined viable count and be about 10 ⁹Cfu/ml, freezing then, thus prepare the standard inoculation frozen cultures of 4 type streptococcus pneumoniaes.The schema of preparation is as follows:

Line streptococcus pneumoniae culture also confirms its identity

↓

On above-mentioned flat board, cultivate the overnight culture of 4-5 bacterium colony

↓

With animal passage streptococcus pneumoniae culture (the peritoneal injection heart is got blood to collect)

↓

Cultivation is through the pneumococcal overnight culture of animal passage

↓

By cultivating the whole day culture (to predetermined light through the overnight culture of animal passage

Density) and in-70 ℃ freezing-this is the limit of standard

↓

The inoculum that melts an equal portions standard is to carry out viable count

↓

Use the standard inoculation thing to measure effective dose (be referred to as virulence and detect test)

↓

Use the standard inoculation thing of effective dose to carry out all subsequently attacks

With 500 times of the inoculum of equal portions standard dilutions, and be used to inoculate mouse with PBS.

Using the slight anesthetized mice of haloalkane, is 1.4 * 10 with dosage then ⁵The streptococcus pneumoniae of cfu is applied to the nasal cavity of each mouse, and the eupnea of mouse will help taking in streptococcus pneumoniae, allows mouse carry on the back recumbency Wait-to-Restore down.

The Streptococcus pneumoniae vaccine test

(Harlan UK) uses DNA and carry out vaccine test in mouse CBA/ca mouse by giving for 6 ages in week.The mouse for the treatment of immunization is divided into 6 groups, and every group is carried out immunization with reorganization pcDNA3.1+ plasmid DNA, contains required particular target gene order in the described plasmid DNA.100 μ g are dissolved in the preceding tibialis (every leg 50 μ l) of DNA intramuscularly to two leg among the Dulbecco PBS (Sigma) altogether.The identical method of 4 weeks back use is carried out booster immunization.In order to compare, in all vaccine tests, all comprise control group.These control groups or without the animal of immunity, or only used the animal of non-reorganization pcDNA3.1+DNA (false immunity) by time course same as described above.Immunization is after 3 weeks, with attacking all mouse groups in streptococcus pneumoniae serotype 4 (bacterial strain NCTC11886) nose of lethal dose for the second time.Monitor the number of the bacterium of using through the inoculum of serial dilution by tiling inoculation on 5% blood agar flat board.The problem of immunization is in the nose: in some mouse, inoculum comes up as frothing from the nostril, is noticing this problem in the table as a result, and this problem has been taken into account when calculating.More unconspicuous problem is that every mouse may swallow a part of inoculum.Suppose that for every mouse the amount of being swallowed is identical, will reach average in seeded process.Yet employed sample is less, and this problem will produce remarkably influenced to some experiments.After infection 3 or 4 days, kill after the attack still all mouse of survival.In course of infection, induce with streptococcus pneumoniae in the mouse attacked of monitoring-the relevant symptom development of outbreak of disease.Typical symptoms comprises piloerection successively, and the protuberance figure of Zeng Jiaing is flowed out movement in the eyes gradually, and is drowsiness and be reluctant to move.The symptom in later stage is consistent with the generation of moribund condition usually, and the mouse of rejecting moribund condition is so that they no longer suffer misery.It is believed that these mouse are at death's door, use the rejecting time to determine that the survival time is to carry out statistical analysis.When finding dead mouse, the survival time is by as being to think the last time point that mouse still lives through monitoring.

Result's explanation

If cloned and be used for the provide protection that any dna sequence dna of above-mentioned attack experiment can create antagonism and attack, be positive findings.Provide protection is regarded as dna sequence dna can produce significant provide protection (confidence level is 95% (p＜0.05)) on the statistics; with the inadequate or approaching significant provide protection of using Mann-Whitney to find; or demonstrate some protective features, one or many irrelevant mouse are for example arranged or because occur dead time lengthening first.When we thought that associated problem that some results are used intranasal infection make smudgy, being considered to the potential positive findings near remarkable or non-significant result was acceptable.

Vaccine test 2,7 and 8 (see figure 1) as a result

^*-when by this dosage immunity, there is sub-fraction to be emerged as frothing, therefore may not accept whole inoculums.

T-stops when experiment finishes, and does not have infection symptoms.

The survival time of the incomplete dosage that the numeral in the bracket-do not consider is adopted.

P value 1 refers to and the significance test of comparing without the contrast of immunity.

Statistical analysis

Test 2-compares with the contrast without immunization, and the ID210 immune group has long mean survival time, but this result is not very remarkable statistically.

Test 7-compares with the contrast without immunization, and 4172.5 immune group demonstrate the longer survival time, but this difference does not have significance,statistical.

Test 8-compares with the contrast without immunization, and the survival time of ID211 immune group is significantly longer.4197.4 4122.1 and 4126.7 immune group demonstrate than without the longer mean survival time of immune group, but this result is not remarkable statistically.4197.4 with 4126.7 groups of time retardations that occur death first, 4122.1 groups demonstrate 1 irrelevant result.

Streptococcus pneumoniae is attacked the (see figure 2) as a result of dna immunization test 9-11

^*-when by this dosage immunity, there is sub-fraction to be emerged as frothing, therefore may not accept whole inoculums.

T-stops when experiment finishes, and does not have infection symptoms.

The survival time of the incomplete dosage that the numeral in the bracket-do not consider is adopted.

P value 1 refers to and the significance test of comparing without the contrast of immunity.

P value 2 refers to and the significance test of comparing through the contrast of pcDNA3.1+ immunity.

Statistical analysis

Although the test 9-nonsensical statistically, compare with control group without immunity, 4188.11 and the ID209 immune group have perceptible higher mean survival time really.

The test 10-compare with the pcDNA3.1+ immune group, without the control group survival time of immunity significantly longer.Compare with false immune group, ID215 and 4170.4 immune group demonstrate the longer survival time (p=0.0168 and 0.0316) with statistical significance, but can not with compare without immune group.

Test 11-4193.1 immune group is optimal, and its survival time is than pcDNA3.1+ immune group on average long 6.5 hours, and than without immune group leader 6 hours, but this is not remarkable on statistics as a result.

Table 1

4101.1

ATGGAAGAGTTAGTGACCTTAGATTGTTTGTTTATTGACAGAACTAAGATTGAAGCCAATGCCAACAAGTATAGTT

TTGTGTGGAAGAAAACGACAGAGAAATTCTCCGCCAAACTTCAAGAACAGATACAGGTCTATTTTCAAGAAGAAA

TCACTCCCCTTCTGATTAAATATGCCATGTTTGATAAGAAACAAAAGAGAGGGTATAAAGAGTCAGCTAAAAACT

TAGCGAATTGGCACTATAATGACAAGGAGGATAGCTACACACATCCTGATGGCTGGTATTATCGTTTTCACCATAC

CAAATATCAGAAAACACAGACAGACTTTCAACAAGAAATCAAGGTTTACTACGCCGACGAACCTGAATCAGCCCC

TCAAAAGGGACTGTATATGAACGAACGCTATCAAAACTTGAAAGCTAAAGAATGTCAGGCGCTTTTATCTCCCCA

AGGTAGACAGATTTTCGCTCAACGCAAGATTGATGTGGAACCTGTCTTTGGGCAGATAAAGGCTTCTTTGGGTTAC

AAGAGATGTAATCTGAGAGGGAAGCGTCAAGTGAGAATTGACATGGGATTGGTACTTATGGCCAATAACCTCCTA

AAATATAGTAAAATGAAATAA

4101.3

ATGGGGAAAGGCCATTGGAATCGGAAAAGAGTTTATAGCATTCGTAAGTTTGCTGTGGGAGCTTGCTCAGTAATG

ATTGGGACTTGTGCAGTTTTATTAGGAGGAAATATAGCTGGAGAATCTGTAGTTTATGCGGATGAAACACTTATTA

CTCATACTGCTGAGAAACCTAAAGAGGAAAAAATGATAGTAGAAGAAAAGGCTGATAAAGCTTTGGAAACTAAA

AATATAGTTGAAAGGACAGAACAAAGTGAACCTAGTTCAACTGAGGCTATTGCATCTGAGAAGAAAGAAGATGAA

GCCGTAACTCCAAAAGAGGAAAAAGTGTCTGCTAAACCGGAAGAAAAAGCTCCAAGGATAGAATCACAAGCTTC

AAATCAAGAAAAACCGCTCAAGGAAGATGCTAAAGCTGTAACAAATGAAGAAGTGAATCAAATGATTGAAGACA

GGAAAGTGGATTTTAATCAAAATTGGTACTTTAAACTCAATGCAAATTCTAAGGA?AGCCATTAAACCTGATGCAG

ACGTATCTACGTGGAAAAAATTAGATTTACCGTATGACTGGAGTATCTTTAACGATTTCGATCATGAATCTCCTGC

ACAAAATGAAGGTGGACAGCTCAACGGTGGGGAAGCTTGGTATCGCAAGACTTTCAAACTAGATGAAAAAGACCT

CAAGAAAAATGTTCGCCTTACTTTTGATGGCGTCTACATGGATTCTCAAGTTTATGTCAATGGTCAGTTAGTGGGG

CATTATCCAAATGGTTATAACCAGTTCTCATATGATATCACCAAATACCTTCAAAAAGATGGTCGTGAGAATGTGA

TTGCTGTCCATGCAGTCAACAAACAGCCAAGTAGCCGTTGGTATTCAGGAAGTGGTATCTATCGTGATGTGACTTT

ACAAGTGACAGATAAGGTGCATGTTGAGAAAAATGGGACAACTATTTTAACACCAAAACTTGAAGAACAACAACA

TGGCAAGGTTGAAACTCATGTGACCAGCAAAATCGTCAATACGGACGACAAAGACCATGAACTTGTAGCCGAATA

TCAAATCGTTGAACGAGGTGGTCATGCTGTAACAGGCTTAGTTCGTACAGCGAGTCGTACCTTAAAAGCACATGA

ATCAACAAGCCTAGATGCGATTTTAGAAGTTGAAAGACCAAAACTCTGGACTGTTTTAAATGACAAACCTGCCTTG

TACGAATTGATTACGCGTGTTTACCGTGACGGTCAATTGGTTGATGCTAAGAAGGATTTGTTTGGTTACCGTTACT

ATCACTGGACTCCAAATGAAGGTTTCTCTTTGAATGGTGAACGTATTAAATTCCATGGAGTATCCTTGCACCACGA

CCATGGGGCGCTTGGAGCAGAAGAAAACTATAAAGCAGAATATCGCCGTCTCAAACAAATGAAGGAGATGGGAG

TTAACTCCATCCGTACAACCCACAACCCTGCTAGTGAGCAAACCTTGCAAATCGCAGCAGAACTAGGTTTACTCGT

TCAGGAAGAGGCCTTTGATACGTGGTATGGTGGCAAGAAACCTTATGACTATGGACGTTTCTTTGAAAAAGATGC

CACTCACCCAGAAGCTCGAAAAGGTGAAAAATGGTCTGATTTTGACCTACGTACCATGGTCGAAAGAGGCAAAAA

CAACCCTGCTATCTTCATGTGGTCAATTGGTAATGAAATAGGTGAAGCTAATGGTGATGCCCACTCTTTAGCAACT

GTTAAACGTTTGGTTAAGGTTATCAAGGATGTTGATAAGACTCGCTATGTTACCATGGGAGCAGATAAATTCCGTT

TCGGTAATGGTAGCGGAGGGCATGAGAAAATTGCTGATGAACTCGATGCTGTTGGATTTAACTATTCTGAAGATA

ATTACAAAGCCCTTAGAGCTAAGCATCCAAAATGGTTGATTTATGGATCAGAAACATCTTCAGCTACCCGTACACG

TGGAAGTTACTATCGCCCTGAACGTGAATTGAAACATAGCAATGGACCTGAGCGTAATTATGAACAGTCAGATTA

TGGAAATGATCGTGTGGGTTGGGGGAAAACAGCAACCGCTTCATGGACTTTTGACCGTGACAACGCTGGCTATGC

TGGACAGTTTATCTGGACAGGTACGGACTATATTGGTGAACCTACACCATGGCACAACCAAAATCAAACTCCTGTT

AAGAGCTCTTACTTTGGTATCGTAGATACAGCCGGCATTCCAAAACATGACTTCTATCTCTACCAAAGCCAATGGG

TTTCTGTTAAGAAGAAACCGATGGTACACCTTCTTCCTCACTGGAACTGGGAAACAAAGAATTAGCATCCAAAG

TAGCTGACTCAGAAGGTAAGATTCCAGTTCGTGCTTATTCGAATGCTTCTAGTGTAGAATTGTTCTTGAATGGAAA

ATCTCTTGGTCTTAAGACTTTCAATAAAAAACAAACCAGCGATGGGCGGACTTACCAAGAAGGTGCAAATGCTAA

TGAACTTTATCTTGAATGGAAAGTTGCCTATCAACCAGGTACCTTGGAAGCAATTGCTCGTGATGAATCTGGCAAG

GAAATTGCTCGAGATAAGATTACGACTGCTGGTAAGCCAGCGGCAGTTCGTCTTATTAAGGAAGACCATGCGATT

GCAGCAGATGGAAAAGACTTGACTTACATCTACTATGAAATTGTTGACAGCCAGGGGAATGTGGTTCCAACTGCT

AATAATCTGGTTCGCTTCCAATTGCATGGCCAAGGTCAACTGGTCGGTGTAGATAACGGAGAACAAGCCAGCCGT

GAACGCTATAAGGCGCAAGCAGATGGTTCTTGGATTCGTAAAGCATTTAATGGTAAAGGTGTTGCCATTGTCAAAT

CAACTGAACAAGCAGGGAAATTCACCCTGACTGCCCACTCTGATCTCTTGAAATCGAACCAAGTCACTGTCTTTAC

TGGTAAGAAAGAAGGACAAGAGAAGACTGTTTTGGGGACAGAAGTGCCAAAAGTACAGACCATTATTGGAGAGG

CACCTGAAATGCCTACCACTGTTCCGTTTGTATACAGTGATGGTAGCCGTGCAGAACGTCCTGTAACCTGGTCTTC

AGTAGATGTGAGCAAGCCTGGTATTGTAACGGTGAAAGGTATGGCTGACGGACGAGAAGTAGAAGCTCGTGTAGA

AGTGATTGCTCTTAAATCAGAGCTACCAGTTGTGAAACGTATTGCTCCAAATACTGACTTGAATTCTGTAGACAAA

TCTGTTTCCTATGTTTTGATTGATGGAAGTGTTGAAGAGTATGAAGTGGACAAGTGGGAGATTGCCGAAGAAGATA

AAGCTAAGTTAGCAATTCCAGGTTCTCGTATTCAAGCGACCGGTTATTTAGAAGGTCAACCAATTCATGCAACCCT

TGTGGTAGAAGAAGGCAATCCTGCGGCACCTGCAGTACCAACTGTAACGGTTGGTGGTGAGGCAGTAACAGGTCT

TACTAGTCAAAAACCAATGCAATACCGCACTCTTGCTTATGGAGCTAAGTTGCCAGAAGTCACAGCAAGTGCTAA

AAATGCAGCTGTTACAGTTCTTCAAGCAAGCGCAGCAAACGGCATGCGTGCGAGCATCTTTATTCAGCCTAAAGA

TGGTGGCCCTCTTCAAACCTATGCAATTCAATTCCTTGAAGAAGCGCCAAAAATTGCTCACTTGAGCTTGCAAGTG

GAAAAAGCTGACAGTCTCAAAGAAGACCAAACTGTCAAATTGTCGGTTCGAGCTCACTATCAAGATGGAACGCAA

GCTGTATTACCAGCTGATAAAGTAACCTTCTCTACAAGTGGTGAAGGGGAAGTCGCAATTCGTAAAGGAATGCTT

GAGTTGCATAAGCCAGGAGCAGTCACTCTGAACGCTGAATATGAGGGAGCTAAAGACCAAGTTGAACTCACTATC

CAAGCCAATACTGAGAAGAAGATTGCGCAATCCATCCGTCCTGTAAATGTAGTGACAGATTTGCATCAGGAACCA

AGTCTTCCAGCAACAGTAACAGTTGAGTATGACAAAGGTTTCCCTAAAACTCATAAAGTCACTTGGCAAGCTATTC

CGAAAGAAAAACTAGACTCCTATCAAACATTTGAAGTACTAGGTAAAGTTGAAGGAATTGACCTTGAAGCGCGTG

CAAAAGTCTCTGTAGAAGGTATCGTTTCAGTTGAAGAAGTCAGTGTGACAACTCCAATCGCAGAAGCACCACAAT

TACCAGAAAGTGTTCGGACATATGATTCAAATGGTCACGTTTCATCAGCTAAGGTTGCATGGGATGCGATTCGTCC

AGAGCAATACGCTAAGGAAGGTGTCTTTACAGTTAATGGTCGCTTAGAAGGTACGCAATTAACAACTAAACTTCA

TGTTCGCGTATCTGCTCAAACTGAGCAAGGTGCAAACATTTCTGACCAATGGACCGGTTCAGAATTGCCACTTGCC

TTTGCTTCAGACTCAAATCCAAGCGACCCAGTTTCAAATGTTAATGACAAGCTCATTTCCTACAATAACCAACCAG

CCAATCGTTGGACAAAACTGGAATCGTACTAATCCAGAAGCTTCAGTCGGTGTTCTGTTTGGAGATTCAGGTATCTT

GAGCAAACGCTCCGTTGATAATCTAAGTGTCGGATTCCATGAAGACCATGGAGTTGGTGTACCGAAGTCTTATGTG

ATTGAGTATTATGTTGGTAAGACTGTCCCAACAGCTCCTAAAAACCCTAGTTTTGTTGGTAATGAGGACCATGTCT

TTAATGATTCTGCCAACTGGAAACCAGTTACTAATCTAAAAGCCCCTGCTCAACTCAAGGCTGGAGAAATGAACC

ACTTTAGCTTTGATAAAGTTGAAACCTATGCTGTTCGTATTCGCATGGTTAAAGCAGATAACAAGCGTGGAACGTC

TATCACAGAGGTACAAATCTTTGCGAAACAAGTTGCGGCAGCCAAGCAAGGACAAACAAGAATCCAAGTTGACGG

CAAAGACTTAGCAAACTTCAACCCTGATTTGACAGACTACTACCTTGAGTCTGTAGATGGAAAAGTTCCGGCAGTC

ACAGCAAGTGTTAGCAACAATGGTCTCGCTACCGTCGTTCCAAGCGTTCGTGAAGGTGAGCCAGTTCGTGTCATCG

CGAAAGCTGAAAATGGCGACATCTTAGGAGAATACCGTCTGCACTTCACTAAGGATAAGAGCTTACTTTCTCATA

AACCAGTTGCTGCGGTTAAACAAGCTCGCTTGCTACAAGTAGGTCAAGCACTTGAATTGCCGACTAAGGTTCCAGT

TTACTTCACAGGTAAAGACGGCTACGAAACAAAAGACCTGACAGTTGAATGGGAAGAAGTTCCAGCGGAAAATCT

GACAAAAGCAGGTCAATTTACTGTTCGAGGCCGTGTCCTTGGTAGTAACCTTGTTGCTGAGATCACTGTACGAGTG

ACAGACAAACTTGGTGAGACTCTTTCAGATAACCCTAACTATGATGAAAACAGTAACCAGGCCTTTGCTTCAGCA

ACCAATGATATTGACAAAAACTCTCATGACCGCGTTGACTATCTCAATGACGGAGATCATTCAGAAAATCGTCGTT

GGACAAACTGGTCACCAACACCATCTTCTAATCCAGAAGTATCAGCGGGTGTGATTTTCCGTGAAAATGGTAAGA

TTGTAGAACGGACTGTTACACAAGGAAAAGTTCAGTTCTTTGCAGATAGTGGTACGGATGCACCATCTAAACTCGT

TTTAGAACGCTATGTCGGTCCAGAGTTTGAAGTGCCAACCTACTATTCAAACTACCAAGCCTACGACGCAGACCAT

CCATTCAACAATCCAGAAAATTGGGAAGCTGTTCCTTATCGTGCGGATAAAGACATTGCAGCTGGTGATGAAATC

AACGTAACATTTAAAGCTATCAAAGCCAAAGCTATGAGATGGCGTATGGAGCGTAAAGCAGATAAGAGCGGTGTT

GCGATGATTGAGATGACCTTCCTTGCACCAAGTGAATTGCCTCAAGAAAGCACTCAATCAAAGATTCTTGTAGATG

GAAAAGAACTTGCTGATTTCGCTGAAAATCGTCAAGACTATCAAATTACCTATAAAGGTCAACGGCCAAAAGTCT

CAGTTGAAGAAAACAATCAAGTAGCTTCAACTGTGGTAGATAGTGGAGAAGATAGCTTTCCAGTACTTGTTCGCCT

CGTTTCAGAAAGTGGAAAACAAGTCAAGGAATACCGTATCCACTTGACTAAGGAA

AAACCAGTTTCTGAGAAGACAGTTGCTGCTGTACAAGAAGATCTTCCAAAAATCGAATTTGTTGAAAAAGATTTG

GCATACAAGACAGTTGAGAAAAAAGATTCAACACTGTATCTAGGTGAAACTCGTGTAGAACAAGAAGGAAAAGTT

GGAAAAGAACGTATCTTTACAGCGATTAATCCTGATGGAAGTAAGGAAGAAAAACTCCGTGAAGTGGTAGAAGTT

CCGACAGACCGCATCGTCTTGGTTGGAACCAAACCAGTAGCTCAAGAAGCTAAAAAACCACAAGTGTCAGAAAAA

GCAGATACAAAACCAATTGATTCAAGTGAAGCTAGTCAAACTAATAAAGCCCAGTTACCAAGTACAGGTAGTGCG

GCAAGCCAAGCAGCAGTAGCAGCAGGTTTAACTCTTCTAGGTTTGAGTGCAGGATTAGTAGTTACTAAAGGTAAA

AAAGAAGACTAG

4101.5

ATGGATGCAATCTTTGACCTAATCGGAAAGGTTTTCAATCCCATCTTAGAAATGGGTGGACCTGTCATCATGTTAA

TCATTTTGACAGTATTGGCTTTACTTTTTGGAGTGAAATTCTCCAAAGCGCTTGAAGGTGGTATCAAACTTGCCAT

CGCTCTTACAGGTATCGGTGCTATCATCGGTATGCTAAACACTGCTTTCTCAGCATCACTAGCAAAATTCGTTGAA

AACACTGGTATCCAATTGAGTATTACCGACGTTGGTTGGGCACCACTTGCTACAATCACTTGGGGTTCTGCTTGGA

CACTATACTTCTTGCTCATCATGTTGATTGTCAACATAGTGATGCTAGCTATGAAGAAAACAGATACACTTGATGT

CGATATCTTTGATATCTGGCACTTGTCTATCACAGGTCTCTTGATTAAATGGTATGCTGATAACAATGGTGTGAGT

CAAGGGGTTTCACTCTTTATTGCTACAGCAGCTATCGTCCTTGTCGGTGTGTTGAAAATTATCAACTCTGACTTGAT

GAAACCTACATTTGATGACCTTCTTAACGCCCCAAGTTCATCACCAATGACATCAACTCACATGAACTACATGATG

AACCCAGTTATCATGGTTTTGGATAAGATTTTTGAAAAATTCTTCCCAGGCCTTGATAAATATGACTTTGATGCTG

CTAAATTGAACAAGAAAATCGGTTTCTGGGGATCTAAATTCTTCATCGGTTTCATCCTTGGTATCGTTATCGGTATT

ATGGGAACTCCACATCCAATTGCAGGTGTTGCAGATGCAGATAAATGGCGTCTTGTTATCAAAGGATGGTTGTCTC

TTGGTTTGACTGCCGGTGTATCTTTGGAACTCTTCTCACTTATCGGTTCATGGTTCATCGCAGCCGTAGAACCACTA

TCACAAGGTATTACAAACGTTGCTACTAAACGTCTTCAAGGACGTAAATTCAATATCGGTCTTGACTGGCCATTCA

TCGCTG?GTCGTGCTGAAATCTGGGCTTGTGCCAACGTACTTGCACCAATCATGTTGATTGAAGCAGTGCTTCTTTC

AAAAGTTGGAAATGGTATCTTGCCACTTGCAGGTATCATCGCTATGGGTGTTACTCCAGCTCTCTTGGTTGTAACT

CGTGGTAAATTGCTCCGTATGATTATCTTCGGAACACTCTTGTTGCCACTCTTCCTTCTTTCAGGTACACTTATTGC

ACCATTTGCAACAGAACTTGCTAAAGGTGTAGGTGCCTTCCCAGAAGGTGTGAGCCAAACTCAATTGATTACTCAC

TCTACTCTTGAAGGACCAATCGAAAAACTTCTTGGTTGGACAATTGGTAACACTACAACTGGTGATATCAAAGCAA

TCCTTGGTGCAGTAGTCTTCCTTGTATTCTATATCGGTATCTTTGCTTGGTACAGAAAACAAATGATCAAACGTAA

CGAAGAGTACGCAGCAAAAGCAAAATAA

4102.1

ATGAAGATTATGAAAAAAAAATATTGGACTTTAGCGATATTATTCTTTTGTTTGTTCAATAATTCTGTTACTGCTCA

AGAAATACCTAAAAATCTTGATGGCAATATAACTCACACTCAGACTAGCGAAAGTTTTTCTGAATCTGATGAAAA

ACAGGTTGACTATTCTAATAAAAATCAAGAAGAAGTAGACCAAAATAAATTTCGTATTCAAATCGATAAGACAGA

ATTATTTGTAACAACAGATAAACATTTAGAAAAAAACTGTTGTAAATTGGAACTTGAACCACAAATAAATAACGA

TATTGTTAACTCTGAAAGTAATAATTTACTAGGCGAAGATAATTTAGATAATAAAATTAAGGAAAATGTTTCTCAT

CTAGATAATAGAGGAGGAAATATAGAGCATGACAAAGATAACTTAGAATCGTCGATTGTAAGAAAATATGAATGG

GATATAGATAAAGTTACTGGTGGAGGCGAAAGTTATAAATTATATTCTAAAAGTAATTCTAAAGTTTCAATTGCTA

TTTTAGATTCAGGAGTCGATTTACAAAATACTGGATTACTGAAAAATCTTTCAAATCACTCAAAAAACTATGTCCC

CAATAAAGGATATTTAGGAAAAGAGGAGGGAGAGGAAGGAATAATATCAGATATTCAAGATAGATTAGGTCATG

GTACGGCTGTTGTAGCTCAAATTGTAGGGGATGACAATATTAATGGAGTAAATCCTCACGTTAATATTAACGTCTA

TAGAATATTTGGTAAGTCGTCAGCTAGTCCAGATTGGATTGTAAAAGCAATTTTTGATGCTGTAGATGATGGCAAT

GATATTATCAATCTTAGTACTGGACAATATTTAATGATTGATGGAGAATATGAGGACGGAACAAATGATTTTGAAA

CATTTTTGAAGTATAAAAAGGCTATTGATTACGCGAATCAAAAAGGAGTAATTATAGTAGCTGCATTAGGGAATG

ACTCCCTAAATGTATCAAATCAGTCAGATTTATTGAAACTTATTAGTTCACGCAAAAAAGTAAGAAAACCAGGATT

AGTAGTTGATGTTCCAAGTTATTTCTCATCTACAATTTCGGTCGGAGGCATAGATCGCTTAG

GTAATTTATCAGATTTTAGCAATAAAGGGGATTCTGATGCAATATATGCGCCTGCAGGCTCAACATTATCTCTTTC

AGAATTAGGACTTAATAACTTTATTAATGCAGAAAAATATAAAGAAGATTGGATTTTTTCGGCAACACTAGGAGG

ATATACGTATCTTTATGGAAACTCATTTGCTGCTCCTAAAGTTTCTGGTGCGATTGCAATGATTATTGATAAATACA

AATTAAAAGATCAGCCCTATAATTATATGTTTGTAAAAAAATTCTGGAAGAAACATTACCAGTAA

4106.1

ATGAAGAAAACATGGAAAGTGTTTTTAACGCTTGTAACAGCTCTTGTAGCTGTTGTGCTTGTGGCCTGTGGTCAAG

GAACTGCTTCTAAAGACAACAAAGAGGCAGAACTTAAGAAGGTTGACTTTATCCTAGACTGGACACCAAATACCA

ACCACACAGGGCTTTATGTTGCCAAGGAAAAAGGTTATTTCAAAGAAGCTGGAGTGGATGTTGATTTGAAATTGC

CACCAGAAGAAAGTTCTTCTGACTTGGTTATCAACGGAAAGGCACCATTTGCAGTGTATTTCCAAGACTACATGGC

TAAGAAATTGGAAAAAGGAGCAGGAATCACTGCCGTTGCAGCTATTGTTGAACACAATACATCAGGAATCATCTC

TCGTAAATCTGATAATGTAAGCAGTCCAAAAGACTTGGTTGGTAAGAAATATGGGACATGGAATGACCCAACTGA

ACTTGCTATGTTGAAAACCTTGGTAGAATCTCAAGGTGGAGACTTTGAGAAGGTTGAAAAAGTACCAAATAACGA

CTCAAACTCAATCACACCGATTGCCAATGGCGTCTTTGATACTGCTTGGATTTACTACGGTTGGGATGGTATCCTT

GCTAAATCTCAAGGTGTAGATGCTAACTTCATGTACTTGAAAGACTATGTCAAGGAGTTTGACTACTATTCACCAG

TTATCATCGCAAACAACGACTATCTGAAAGATAACAAAGAAGAAGCTCGCAAAGTCATCCAAGCCATCAAAAAAG

GCTACCAATATGCCATGGAACATCCAGAAGAAGCTGCAGATATTCTCATCAAGAATGCACCTGAACTCAAGGAAA

AACGTGACTTTGTCATCGAATCTCAAAAATACTTGTCAAAAGAATACGCAAGCGACAAGGAAAAATGGGGTCAAT

TTGACGCAGCTCGCTGGAATGCTTTCTACAAATGGGATAAAGAAAATGGTATCCTTAAAGAAGACTTGACAGACA

AAGGCTTCACCAACGAATTTGTGAAATAA

4106.4

ATGATAAAAAATCCTAAATTATTAACCAAGTCTTTTTTAAGAAGTTTTGCAATTCTAGGTGGTGTTGGTCTAGTCA

TTCATATAGCTATTTATTTGACCTTTCCTTTTTATTATATTCAACTGGAGGGGGAAAAGTTTAATGAGAGCGCAAG

AGTGTTTACGGAGTATTTAAAGACTAAGACATCTGATGAAATTCCAAGCTTACTCCAGTCTTATTCAAAGTCCTTG

ACCATATCTGCTCACCTTAAAAGAGATATTGTAG?ATAAGCGGCTCCCTCTTGTGCATGACTTGGATATTAAAGATG

GAAAGCTATCAAATTATATCGTGATGTTAGATATGTCTGTTAGTACAGCAGATGGTAAACAGGTAACCGTGCAATT

TGTTCACGGGGTGGATGTCTACAAAGAAGCAAAGAATATTTTGCTTTTGTATCTCCCATATACATTTTTGGTTACA

ATTGCTTTTTCCTTTGTTTTTTCTTATTTTTATACTAAACGCTTGCTCAATCCTCTTTTTTACATTTCAGAAGTGACT

AGTAAAATGCAAGATTTGGATGACAATATTCGTTTTGATGAAAGTAGGAAAGATGAAGTTGGTGAAGTTGGAAAA

CAGATTAATGGTATGTATGAGCACTTGTTGAAGGTTATTTATGAGTTGGAAAGTCGTAATGAGCAAATTGTAAAAT

TGCAAAATCAAAAGGTTTCCTTTGTCCGCGGAGCATCACATGAGTTGAAAACCCCTTTAGCCAGTCTTAGAATTAT

CCTAGAGAATATGCAGCATAATATTGGAGATTACAAAGATCATCCAAAATATATTGCAAAGAGTATAAATAAGAT

TGACCAGATGAGCCACTTATTAGAAGAAGTACTGGAGTCTTCTAAATTCCAAGAGTGGACAGAGTGTCGTGAGAC

CTTGACTGTTAAGCCAGTTTTAGTAGATATTTTATCACGTTATCAAGAATTAGCTCATTCAATAGGTGTTACAATTG

AAAATCAATTGACAGATGCTACCAGGGTCGTCATGAGTCTTAGGGCATTGGATAAGGTTTTGACAAACCTGATTA

GTAATGCAATTAAATATTCAGATAAAAATGGGCGTGTAATCATATCCGAGCAAGATGGCTATCTCTCTATCAAAA

ATACATGTGCGCCTCTAAGTGACCAAGAACTAGAACATTTATTTGATATATTCTATCATTCTCAAATCGTGACAGA

TAAGGATGAAAGTTCCGGTTTGGGTCTTTACATTGTGAATAATATTTTAG?AAAGCTATCAAATGGATTATAGTTTT

CTCCCTTATGAACACGGTATGGAATTTAAGATTAGCTTGTAG

4106.6

ATGTATTTAGGAGATTTGATGGAGAAAGCCGAGTGTGGTCAATTTTCAATACTTTCCTTTCTATTACAAGAGTCTC

AGACGACCGTCAAGGCTGTAATGGAAGAAACAGGATTTTCAAAAGCAACCCTAACCAAATATGTCACCCTGCTCA

ATGACAAGGCTTTGGATAGTGGCTTAGAGCTGGCTATTCACTCAGAAGATGAAAATCTGCGTCTGTCTATCGGTGC

AGCTACCAAGGGGAGAGATATTCGGAGCTTGTTTTTGGAGAGTGCTGTTAAATACCAGATTTTGGTTTATCTTCTC

TACCACCAACAGTTTTTAGCCCATCAGCTGGCTCAAGAATTGGTGATTAGCGAGGCTACGCTTGGTCGTCACTTGG

CTGGTTTAAATCAGATTTTGTCAGAATTTGATTTATCCATCCAAAATGGCCGTTGGCGAGGTCCAGAGCATCAGAT

TCACTATTTCTATTTCTGTCTTTTCCGAAAGGTCTGGTCGAGTCAGGAATGGGAAGGTCACATGCAGAAACCAGAG

AGAAAACAGGAGATTGCCAATTTAGAGGAAATCTGCGGTGCAAGTTTGTCTGCGGGGCAGAAATTGGACTTGGTT

CTCTGGGCTCACATCAGTCAACAACGTCTTCGGGTCAATGCTTGTCAGTTTCAAGTCATAGAAGAGAAAATGCGA

GGGTATTTTGACAATATCTTTTATCTTCGTTTGCTGAGAAAGGTTCCGTCCTTTTTTGCTGGGCAACATATTCCACT

AGGAGTTGAGGATGGTGAGATGATGATATTCTTCTCTTTTCTCCTATCTCATCGCATTCTTCCTCTTCATACTATGG

AGTATATTCTTGGTTTTGGAGGGCAGTTGGCAGATTTACTGACGCAATTGATTCAAGAAATGAAGAAGGAGGAAC

TATTGGGGGATTATACAGAGGACCATGTCACCTATGAACTCAGTCAGCTTTGTGCTCAAGTCTATCTCTATAAGGG

CTATATTTTACAGGATCGCTACAAGTACCAGTTAGAGAATCGTCATCCATATTTACTGATGGAACATGATTTTAAA

GAGACAGCAGAGGAGATTTTTCATGCTCTACCTGCTTTTCAACAGGGGACAGATTTAGATAAGAAGATTCTCTGGG

AATGGCTCCAGTTAATCGAATATATGGCTGAAAACGGTGGCCAGCATATGCGGATTGGTCTGGATTTGACATCTGG

TTTTCTTGTCTTTTCAAGGATGGCAGCCATTTTGAAACGGTATTTGGAATACAATCGTTTTATTACCATTGAAGCTT

ATGACCCTAGTCGGCATTATGATTTGCTGGTTACCAATAACCCGATTCATAAGAAGGAACAGACACCAGTCTATTA

TTTAAAAAATGACTTGGATATGGAGGATTTGGTAGCGATTCGCCAGTTATTATTCACTTAA

4106.7

ATGGAATTTTCAAAGAAAACACGTGAATTGTCAATTAAAAAAATGCAGGAACGTACCCTGGACCTCTTGATTATC

GGTGGAGGAATCACAGGAGCTGGTGTAGCCTTGCAGGCGGCAGCTAGCGGTCTTGAGACTGGTTTGATTGAAATG

CAAGACTTTGCAGAAGGAACATCTAGTCGTTCAACAAAATTGGTTCACGGAGGACTTCGTTACCTCAAACAATTTG

ACGTAGAAGTGGTCTCAGATACGGTTTCTGAACGTGCAGTGGTTCAACAAATCGCTCCACACATTCCAAAATCAG

ATCCAATGCTCTTACCAGTTTACGATGAAGATGGAGCAACCTTTAGCCTCTTCCGTCTTAAAGTAGCCATGGACTT

GTACGACCTCTTGGCAGGTGTTAGCAACACACCAGCTGCGAACAAGGTTTTGAGCAAGGATCAAGTCTTGGAACG

CCAGCCAAACTTGAAGAAGGAAGGCTTGGTAGGAGGTGGAGTGTATCTTGACTTCCGTAACAACGATGCGCGTCT

CGTGATTGAAAACATCAAACGTGCCAACCAAGACGGTGCCCTCATTGCCAACCACGTGAAGGCAGAAGGCTTCCT

CTTTGACGAAAGTGGCAAGATTACAGGTGTTGTAGCTCGTGATCTCTTGACAGACCAAGTGTTTGAAATCAAGGCC

CGTCTGGTTATTAATACAACAGGTCCTTGGAGTGATAAAGTACGTAATTTGTCTAATAAGGGAACGCAATTCTCAC

AAATGCGCCCAACTAAGGGAGTTCACTTGGTAGTAGATTCAAGCAAAATCAAGGTTTCACAGCCAGTTTACTTCG

ACACAGGTTTGGGTGACGGTCGTATGGTCTTTGTTCTCCCACGTGAAAACAAGACTTACTTTGGTACAACTGATAC

AGACTACACAGGTGATTTGGAGCATCCAAAAGTAACTCAAGAAGATGTAGATTATCTACTTGGCATTGTCAACAA

CCGCTTCCCAGAATCCAACATCACCATTGATGATATCGAAAGCAGCTGGGCAGGTCTTCG

TCCATTGATTGCAGGGAACAGTGCCTCTGACTATAATGGTGGAAATAACGGTACCATCAGTGATGAAAGCTTTGA

CAACTTGATTGCGACTGTTGAATCTTATCTCTCCAAAGAAAAAACACGTGAAGATGTTGAGTCTGCTGTCAGCAAG

CTTGAAAGTAGCACATCTGAGAAACATTTGGATCCATCTGCAGTTTCTCGTGGGTCTAGCTTGGACCGTGATGACA

ATGGTCTCTTGACTCTTGCTGGTGGTAAAATCACAGACTACCGTAAGATGGCTGAAGGAGCTATGGAGCGCGTGG

TTGACATCCTCAAAGCAGAATTTGACCGTAGCTTTAAATTGATCAATTCTAAAACTTACCCTGTTTCAGGTGGAGA

ATTGAACCCAGCAAATGTGGATTCAGAAATCGAAGCCTTTGCGCAACTTGGAGTATCACGTGGTTTGGATAGCAA

GGAAGCTCACTATCTGGCAAATCTTTACGGTTCAAATGCACCGAAAGTCTTTGCACTTGCTCACAGCTTGGAACAA

GCGCCAGGACTCAGCTTGGCAGATACTTTGTCCCTTCACTATGCAATGCGCAATGAGTTGACTCTTAGCCCAGTTG

ACTTCCTTCTTCGTCGTACCAATCACATGCTCTTTATGCGTGATAGCTTGGATAGTATCGTTGAGCCAATTTTGGAT

GAAATGGGACGATTCTATGACTGGACAGAAGAAGAAAAAGCAACTTACCGTGCTGATGTCGAAGCAGCTCTCGCT

AACAACGATTTAGCAGAATTAAAAAATTAA

4106.8

ATGATGAATGAATTATTTGGAGAATTTCTAGGGACTTTAATCCTGATTCTTCTAGGAAATGGTGTTGTTGCAGGTG

TGGTTCTTCCTAAAACCAAGAGCAATAGCTCAGGTTGGATTGTGATTACTATGGGTTGGGGGATTGCAGTTGCGGT

TGCAGTCTTTGTATCTGGCAAGCTCAGTCCAGCTTATTTAAACCCAGCTGTGACCATCGGTGTGGCCTTAAAAGGT

GGTTTGCCTTGGGCTTCCGTTTTGCCTTATATCTTAGCCCAGTTCGCAGGGGCCATGCTGGGTCAGATTTTGGTTTG

GTTGCAATTCAAACCTCACTATGAGGCAGAAGAAAATGCAGGCAATATCCTGGCAACCTTCAGTACTGGACCAGC

CATCAAGGATACTGTATCAAACTTGATTAGCGAAATCCTTGGAACTTTTGTTTTGGTGTTGACAATCTTTGCTTTGG

GTCTTTACGACTTTCAGGCAGGTATCGGAACCTTTGCAGTGGGAACTTTGATTGTCGGTATCGGTCTATCACTAGG

TGGGACAACAGGTTATGCCTTGAACCCAGCTCGTGACCTTGGACCTCGTATCATGCACAGCATCTTGCCAATTCCA

AACAAGGGAGACGGAGACTGGTCTTACGCTTGGATTCCTGTTGTAG?GCCCTGTTATCGG?AGCAGCCTTGGCAGTG

CTTGTATTCTCACTTTTCTAG

4106.10

ATGAAAAGGACCTGGAGGAACTCATTCGTGACAAATCTTAATACACCTTTTATGATTGGCAATATTGAGATTCCCA

ATCGTACCGTTTTAGCGCCTATGGCTGGCGTGACCAACTCAGCCTTTCGTACTATCGCAAAGGAGCTCGGAGCTGG

ACTCGTTGTAATGGAAATGGTCTCTGACAAGGGAATCCAATACAACAACGAAAAAACCCTGCACATGCTTCATAT

CGATGAGGGCGAAAACCCTGTCTCTATCCAACTTTTTGGTAGCGATGAAGACAGCCTAGCACGCGCAGCAGAATT

CATCCAAGAAAACACCAAGACCGATATCGTCGATATCAACATGGGCTGCCCTGTCAACAAAATCGTGAAGAACGA

AGCTGGTGCTATGTGGCTCAAGGATCCAGACAAGATTTACTCCATCATCAACAAGGTCCAGTCTGTCCTTGATATC

CCACTTACTGTCAAAATGCGTACCGGCTGGGCGGACCCATCTCTTGCAGTAGAAAATGCTCTCGCTGCTGAAGCTG

CAGGTGTTTCTGCCCTCGCCATGCATGGCCGTACCCGTGAACAAATGTATACTGGCCACGCAGACCTTGAGACCCT

TTACAAGGTTGCCCAAGCTCTAACCAAGATTCCATTCATCGCCAACGGTGATATCCGTACTGTCCAAGAAGCCAA

GCAACGCATCGAAGAAGTTGGTGCTGACGCAGTCATGATTGGCCGAGCTGCCATGGGAAATCCTTACCTCTTCAA

CCAAATCAACCATTACTTTGAAACAGGAGAAATCCTACCTGATTTGACCTTTGAAGACAAGATGAAGATCGCCTA

CGAACACTTGAAACGATTGATTAACCTCAAAGGAGAAAACGTCGCAGTTCGTGAATTCCGCGGTCTCGCTCCTCA

CTATCTCCGTGGAACATCTGGCGCTGCCAAACTCCGTGGAGCCATTTCGCAAGCCAGCACCCTGGCAGAGATTGA

AACCCTCTTGCAATTGGAGAAGGCTTAA

4107.1

ATGACAAAGAAGAAAATTGAGCGTATTTCTGTAATACACCGAGAAAAGATTTTATGGCTCAAGTGGTATTTCATGC

GAGATAAAGAACAACCTAAGTATAGTGTCCTTGAGCGTAAAATGTTTGATGCTGCTAAAAATCAAGATATGCTAG

CTTATCAAAAATACGCAACTATCAAGCAGATAACAGATATTAGGGTACAAACAAGTGAGGCTGACATTTTAGAGG

CTGTAAAAGAGGTTTATGTGTACAATCACATGAATGTTATCGGAGCTTGTCAGCGGATATTATTTATCAGTCAATC

ACCAGCTTATGATAAGTTAAATAAGTGGTTTAATATCTATTCTGATTTGTATTTTAGCGTTGTACCCTTGCCCAAAA

TGGGGGTATATCATGAGATGGTAGGTATCTAG

4107.2

ATGAAAAATTCCAACGAGGCTGAGATGAAATTACTTTATACTGATATTCGGACTTCTTTGACAGAAATTCTAACAA

GAGAGGCAGAAGAGCTAGTTGCAGCTGGCAAGCGGGTCTTCTACATTGCCCCCAACTCTCTTTCTTTTGAAAAGGA

ACGCGCCGTGCTGGAATACTTGTCCCAGCAGGCTTCTTTTTCGATTACCGTCACGCGCTTTGCTCAAATGGCTCGC

TATCTGGTCTTGAATGATTTACCAGCTAAAACTACTCTTGATGATATCGGTCTTGGGTTGGCCTTTTACAAATGCCT

TGCCGAACTCGATCCCAAGGACTTGCGTGTTTATGGCGCTATTAAGCAGGATCCTCAATTGATCCAGCAGTTAATT

GAGCTTTACCATGAGATGACCAAATCTCAGATGAGTTTTTTGG?ACTTGGAGAATTTAACAGATGAGGATAAGAGG

GCGGATTTACTCTTGATTTTTGAGAAAGTAACAGCCTATCTTAATCAAGGTCAGTTAGCCCAGGAAAGTCAGTTGT

CCCATTTGATTGAGGCTATTGAGAATGACAAGGTAAGTAGTGATTTTAATCAAATCGCCTTGGTCATTGACGGCTT

TACTCGTTTTTCTGCTGAGGAAGAGCGGGTTGTGGACTTACTTCACGGCAAAGGTGTTGAGATTGTTATCGGGGCT

TATGCTAGTAAGAAAGCCTATACCAGTCCTTTTAGCGAGGGCAATCTCTACCAAGCCAGCGTAAAATTTCTCCATC

ATCTGGCTTCTAAATACCAAACGCCTGCTCAGGACTGTTCTCAAACTCATGAGAAGATGGATAGTTTTGACAAGGC

CTCTCGTTTGTTGGAGTCTTCTTATGACTTTTCAGAACTCGCTTTGGATGTCGATGAGAAAGACCGTGAAAATTTA

CAAATCTGGTCTTGTTTGACGCAAAAGGAGGAGTTGGAGCTAGTAGCCCGTAGTATTCGTCAGAAATTACATGAG

AACTCAGACCTGAGCTACAAGCATTTTCGTATTCTCTTGGGGGATGTAGCTTCTTACCAGTTATCTCTCAAAACCA

TTTTTGACCAGTATCAGATTCCTTTTTATCTTGGTAGAAGCGAAGCCATGGCTCATCATCCCTTGACTCAGTTTGTC

GAGTCTATTTTAGCTTTAAAACGTTACCGTTTTCGTCAGGAGGATTTGATTAATCTTCTTAGAACTGATTTGTATAC

TGACCTCAGTCAGTCTGATATTGATGCTTTTGAGCAATATATCCGCTATCTTGGTATCAATGGCTTGCCAGCCTTTC

AGCAAACCTTCACCAAATCCCACCATGGAAAATTTAATCTTGAGCGTTTGAATGTCCTCCGCCTGAGAATTTTAGC

ACCTCTTGAAACCCTCTTTGCCAGCCGAAAACAAAAGGCTGAAAAACTCCTACAAAAATGGAGTGTCTTTCTAAA

AGAAGGAGCTGTGACCAAGCAGTTACAAG?ATTTGACAACCACTTTGGAAGCTGTAGAACAGGAAAGACAAGCCG

AAGTTTGGAAGGCTTTCTGCCATGTTTTAGAACAATTTGCGACTGTTTTTGCTGGTTCACAGGTTAGTCTGGAAGA

CTTCCTAGCCTTGCTCCATTCTGGAATGAGTTTGTCCCAATACCGTACCATTCCAGCAACAGTGGACACTGTTCTG

GTGCAGAGTTACGATTTGATTGCACCATTGACTGCTGACTTTGTCTATGCTATTGGACTAACTCAGGACAATTTAC

CAAAAATTTCTCAAAACACCAGTCTTCTGACAGATGAAGAAAGGCAAAACCTAAACCAAGCGACCGAAGAAGGC

GTTCAATTACTGATTGCCAGCAGTGAAAATCTCAAGAAAAATCGCTACACTATGCTTTCCTTGGTCAATTCTGCTC

GTAAGCAGTTGTTCTTGTCGGCTCCAAGCCTTTTTAACGAAAGTGAAAGTAAGGAATCTGCCTATCTTCAAGAGTT

GATCCATTTTGGATTTAGGCGGAGAGAGAAGAGGATGAATCACAAAGGACTGTCTAAGGAGGATATGGGGTCCTA

TCACAGTCTTTTGTCTAGTCTGGTTGCCTATCACCAGCAGGGTG?AGATGAGCGATACTGAGCAAGATTTGACTTTT

GTCAAGGTTCTGTCGCGTGTCATAGGTAAAAAACTAGATCAGCA?AGGTCTGGAAAATCCAGCTATCCCAACCAGT

CCAAGCAGCAAGACCTTAGCCAAGGACACCTTGCAAGCTCT

CTATCCTGCCAAACAGGAGTTTTACCTGTCTACGTCGGGTTTGACAGAGTTTTATCGCAATGAATACAGTTATTTC

CTACGCTACGTTTTAGGCTTGCAGGAGGAATTACGTTTGCATCCTGATGCCCGTAGTCACGGGAATTTCTTGCATC

GTATCTTTGAACGCGCCTTACAGTTGCCTAATG?AAGATTCCTTTGACCAACGTCTAGAACAAGCTATTCAAGAAAC

CAGTCAAGAACGCGAATTTGAAGCTATTTATCAAGAAAGTTTGGAAGCCCAGTTTACCAAGGAAGTTTTGCTTGAT

GTTGCACGGACAACTGGACATATTCTCCGACACAATCCAGCCATCGAAACCATCAAAGAAGAAGCAAATTTTGGT

GGAAAAGACCAAGCCTTTATTCAATTAGACAATGGACGCAGTGTCTTTGTACGAGGCAAGGTGGACCGGATTGAC

CGTTTGAAAGCTAATGGAGCGATAGGAGTAGTAGACTACAAATCCAGTCTGACTCAGTTCCAGTTTCCTCATTTCT

TTAATGGGCTCAATTCTCAGTTACCAACCTATCTTGCTGCCCTAAAAAGAGAAGGGGAGCAGAACTTTTTCGGCGC

CATGTACTTGGAAATGGCTGAACCTGTCCAATCTCTGATGGCGGTAAAAAGTCTGGCAGGAGCAGTGGTAGAAGC

CAGCAAATCTATGAAATACCAAGGGCTCTTCTTGGAAAAAGAAAGCAGTTATTTAGGCGAATTTTATAACAAAAA

CAAGGCTAATCAACTGACAGATGAGGAATTTCAGCTCCTACTGGACTACAATGCCTATCTTTACAAGAAAGCTGCT

GAGAAGATTTTAGCAGGCCGGTTCGCCATCAATCCTTATACTGAAAATGGCAGAAGCATTGCCCCATACGTCCAG

CAACATCAGGCTATTACAGGCTTTGAAGCCAATTACCATCTGGGCCAAGCCCGTTTCCTAGAAAAGTTGGACCTAG

CTGATGGCAAGCGTCTGGTCGGAGAAAAACTCAAGCAAGCTTGGCTTGAAAAAATAA

GAGAGGAGTTGAATCGATGA

4107.3

ATGAAGCTTATTCCCTTTTTAAGTGAGGAGGAGATTCAAAAACTGCAAGAAGCAGAAGCAAATTCGAGCAAGGAA

CAGAAGAAAACTGCCGAGCAAATCGAAGCTATCTACACTTCTGCCCAGAATATCCTGGTCTCAGCATCGGCTGGT

TCTGGAAAGACCTTTGTCATGGCAGAGCGCATTCTGGACCAATTGGCGCGTGGTGTCGAAATTTCTCAACTCTTTA

TCTCAACCTTTACCGTCAAGGCTGCAACTGAACTTAAAGAACGTTTAGAGAAAAAAATCAGCAAGAAAATCCAAG

AAACAGATGATGTCGACCTCAAACAACACTTGGGTCGCCAGTTGGCAGACCTACCCAACGCTGCCATTGGAACCA

TGGATTCTTTCACACAAAAATTCCTTGGCAAACATGGTTATCTGCTTGATATTGCACCTAATTTCCGTATTTTACAA

AACCAAAGCGAGCAACTTATTCTCGAAAACGAAGTCTTTCATGAGGTCTTTGAAGCGCATTACCAAGGTAAACAG

AAAGAGACCTTTAGTCATTTGCTGAAAAACTTTGCTGGGCGTGGCAAGGACGAACGGGGTCTGCGCCAGCAGGTC

TATAAAATCTATGACTTCCTCCAATCCACCAGTAATCCTCAAAAGTGGCTGAGTGAATCTTTCCTCAAAGGATTTG

AGAAAGCTGATTTTACCAGTGAAAAAGAAAAACTGACCGAGCAAATCAAACAAGCCCTTTGGGATTTGGAAAGCT

TTTTCCGTTACCATCTGGATAACGATGCCAAGGAGTTTGCAAAGGCTGCCTATTTAGAAAATGTTCAGTTAATTCT

GGATGAAATTGGCTCCCTAAATCAGGAGTCCGATAGTCAGGCTTATCAGGCAGTGCTTGCGCGTGTTGTCGCCATC

TCTAAGGAGAAAAACGGTCGAGCTCTGACTAATGCCAGCCGTAAGGCTGATTTGAAGCCCCTGGCTGATGCCTAC

AACGAAGAGAGAAAGACCCAGTTTGCTAAACTAGGACAATTATCAGACCAGATAGCGAT

TCTCGACTATCAAGAACGTTATCATGGAGACACTTGGAAACTAGCTAAAACCTTCCAATCTTTCATGAGCGATTTT

GTAGAGGCTTATCGTCAGAGAAAACGACAGGAAAATGCCTTCGAATTCGCTGATATCAGCCATTACACCATTGAG

ATTTTAGAGAATTTCCCACAAGTTCGTGAGTCTTATCAGGAGCGCTTCCATGAAGTCATGGTCGATGAGTATCAGG

ATACCAACCATATTCAAGAACGGATGCTGGAATTGTTGTCTAATGGCCACAATCGCTTTATGGTGGGAGATATCAA

GCAATCCATCTATCGTTTCCGTCAGGCAGACCCGCAGATTTTCAATGAGAAATTCCAACGCTATGCGCAAAATCCC

CAAGAAGGCAGGCTCATTATCCTCAAGGAAAATTTCCGTAGTAGTTCAGAAGTGCTGTCAGCAACCAATGATGTC

TTTGAACGTCTCATGGACCAAGAGGTCGGCGAAATCAACTATGATAACAAGCACCAGCTTGTTTTTGCCAATACCA

AACTGACTCCCAATCCAGACAACAAGGCAGCATTTCTCCTCTACGACAAGGACGATACAGGTGAGGAAGAAGAGA

GTCAAACAGAAACGAAACTAACAGGCGAAATGCGCTTAGTTATCAAGGAGATTCTGAAACTTCATCAAGAAAAAG

GTGTTGCCTTTAAGGAAATTGCCCTTCTGACCTCCAGCCGCAGTCGTAATGACCAGATTCTCCTCGCCCTGTCTGA

GTACGGAATTCCTGTCAAAACTGACGGAGAGCAAAACAATTATCTCCAATCCCTAGAAGTGCAAGTCATGCTAGA

CACTCTTCGTGTCATTCACAATCCCCTGCAAGACTACGCCTTGGTTGCCCTTATGAAGTCTCCAATGTTTGGTTTTG

ATGAGGATGAGCTAGCACGTTTGTCCCTTCAGAAAGCAGAGGATAAAGTCCACGAAAATCTCTATGAGAAACTGG

TCAATGCACAAAAAATGGCAAGTAGTCAAAAAGGCTTGATTCACACAGCTCTAGCTG

AAAAACTAAAGCAATTCATGGATATCCTAGCTTCTTGGCGCTTGTATGCCAAAACCCACTCTCTCTATGACTTGAT

TTGGAAGATTTACAACGACCGTTTTTATTATGACTATGTTGGGGCTTTGCCGAATGGTCCTGCTAGGCAGGCCAAT

CTCTATGCCCTAGCACTGCGTGCTGATCAATTTGAAAAGAGCAATTTCAAAGGTTTGTCGCGTTTTATTCGTATGA

TTGACCAAGTCTTAGAAGCCCAGCACGATTTGGCAAGCGTGGCCGTCGCACCGCCAAAAGATGCAGTAGAGCTCA

TGACCATCCACAAGAGTAAAGGGCTGGAGTTTCCTTACGTCTTTATCCTCAATATGGATCAAGATTTCAACAAGCA

AGACTCTATGTCAGAAGTCATTCTCAGTCGTCAGAATGGTCTTGGTGTCAAATATATTGCCAAGATGGAGACAGGG

GCAGTAGAAGACCACTATCCTAAAACCATCAAACTCTCCATTCCTAGTCTGACCTATAGGCAGAACGAAGAGGAA

TTACAGCTAGCAAGCTATTCTGAGCAGATGCGTTTGCTGTATGTTGCTATGACGCGGGCTGAGAAAAAGCTCTATC

TTGTCGGCAAGGGTTCTCGTGAAAAGCTGGAATCCAAGGAATACCCAGCAGCCAAAAATGGGAAACTAAATAGCA

ATACTAGACTGCAAGCACGGAATTTCCAAGATTGGCTTTGGGCTATCAGTAAAGTGTTTACTAAGGACAAGCTCA

ACTTTAGTTATCGTTTTATTGGCGAAGATCAGTTGACCAGAGAAGCTATCGGAGAGTTGGAAACCAAGAGTCCTCT

CCAAGATAGCTCCCAAGCAGACAATCGTCAGTCAGATACCATCAAAGAAGCTCTGGAAATGCTGAAGGAGGTGGA

AGTTTATAATACTCTTCACCGCGCAGCTATTGAACTTCCTAGTGTTCAAACCCCAAGTCAAATCAAGAAATTCTAC

GAACCAGTTATGGATATGGAAGGTGTCGAGATTGCTGGTCAAGGTCAGTCAGTAGGCAAGAAAATCAGCTTCGAT

TTGCCAGATTTTTCAACCAAAGAAAAGGTAACTGGAGCTGAGATTGGTAGTGCTACTCACGAACTCATGCAGAGA

ATTGACCTCAGCCAGCAACTAACCCTTGCTAGCCTAACAGAAACACTCAAACAAGTTCAAACTAGCCAAGCTGTC

AGAGACAAGATCAATCTTGATAAAATTCTTGCTTTCTTTGACACAGTACTCGGTCAGGAAATTCTTGCTAATACCG

ACCATCTTTATCGCGAGCAACCTTTCTCCATGCTCAAACGAGACCAAAAGAGTCAGGAAGACTTTGTTGTCCGTGG

TATCCTTGATGGCTATCTGCTTTACGAAAACAAAATTGTTCTGTTCGACTACAAGACAGACCGCTATGATGAACCA

AGTCAACTCGTAGACCGCTATCGTGGTCAGTTAGCTCTATACGAAGAGGCTTTATCACGAGCCTATTCGATTGAAA

ATATTGAAAAATACTTGATTTTACTCGGTAAAGACGAGGTTCAAGTTGTAAAAGTATAA

4109.1

ATGGAACTTGCTCGCCATGCTGAAAGCTTGGGAGTAGATGCTATTGCAACGATTCCACCAATTTATTTCCGCTTGC

CAGAATACTCAGTTGCCAAATACTGGAACGATATCAGTTCTGCAGCTCCAAACACAGACTACGTGATTTACAACA

TTCCTCAATTGGCAGGGGTTGCTTTGACTCCAAGCCTTTACACAGAAATGTTGAAAAATCCTCGTGTTATCGGTGT

GAAGAACTCTTCTATGCCAGTTCAAGATATCCAAACCTTTGTCAGCCTTGGTGGAGAAGACCATATCGTCTTTAAT

GGTCCTGATGAGCAGTTCCTAGGAGGACGCCTCATGGGGGCTAGGGCTGGTATCGGTGGTACTTATGGTGCTATGC

CAGAACTCTTCTTGAAACTCAATCAGTTGATTGCGGATAAGGACCTAGAAACAGCGCGTGAATTGCAGTATGCTAT

CAACGCAATCATTGGTAAACTCACTTCTGCTCATGGAAATATGTACGGTGTCATCAAAGAAGTCTTGAAAATCAAT

GAAGGCTTGAATATTGGATCTGTTCGTTCACCATTGACACCAGTGACTGAAGAAGATCGTCCAGTTGTAGAAGCG

GCTGCTGCCTTGATTCGTGAAACCAAGGAGCGCTTCCTCTAA

4110.2

ATGTATAAGACAAAGTGTTTACGAGAGAAGTTAGTATTATTTTTAAAAATTTTCTTCCCAATCCTGATCTACCAAT

TTGCCAATTATTCTGCCTCTTTTGTTGATACTGCAATGACAGGTCAATACAACACTATGGACTTGGCTGGTGTATCT

ATGGCAACCAGTATCTGGAATCCTTTCTTTACATTTCTAACAGGGATTGTGTCAGCCTTGGTGCCTATCATTGGTCA

CCATCTTGGTCGAGGCAAAAAGGAAGAAGTTGCGTCTGATTTTTACCAATTTATTTATTTGGCCTTGGGCCTATCT

GTGGTCTTGCTGGGGATGGTACTTTTCTTGGCACCAATAATCTTGAATCATATTGGGTTAGAAGCAGCAGTAGCGG

CAGTAGCGGTTCGCTATCTTTGGTTTTTATCTATCGGGATTATCCCCTTGTTGCTCTTTAGCGTCATTCGTTCCTTGC

TGGATTCGCTGGGCTTGACCAAACTGTCCATGTACCTCATGCTTTTGTTACTCCCTCTCAATAGCGGATTTAACTAT

CTCTTGATTTACGGTGCCTTTGGTGTTCCAGAACTGGGAGGGGCTGGTGCTGGTTTAGGAACATCCTTGGCCTACT

GGGTCTTGCTTGGGATTTCTGTTCTGGTTTTATTTAAACAGGAGAAGCTCAAAGCCTTACACCTTGAGAAACGAAT

TCCACTTAATATGGATAAAATTAAGGAAGGAGTTCGTTTAGGTCTGCCTATTGGGGGAACTGTCTTCGCGGAAGTG

GCTATCTTTTCAGTGGTTGGCTTGATTATGGCTAAGTTTTCGCCCTTGATTATAGCTAGTCACCAGTCAGCTATGAA

CTTTTCAAGTCTTATGTACGCCTTTCCTATGAGTATCTCATCGGCTATGGCTATTGTCGTTTCCTATGAAGTGGGAG

CCAAGCGATTTGATGATGCGAAAACCTATATTGGTCTAGGAAGATGGACTGCCCTCATTTTTGCGGCCTTCACCTT

AACCTTCCTTTACATTTTTAGGGGAAATGTGGCCAGTCTTTATGGTAACGACCCAAAATTTATCGATTTGACAGTG

CGTTTTTTAACTTATAGTCTTTTCTTCCAGTTAGCAGATACCTTTGCGGCGCCGCTTCAGGGAATTTTGCGGGGGTA

TAAGGATACAGTTATTCCTTTTTACCTTGGTTTGCTTGGTTATTGGGGCGTAGCAATCCCTGTGTACGCTATTTGA

4112.2

ATGAGTACTTTAGCAAAAATAGAAGCGCTCTTGTTTGTAGCGGGTGAAGATGGGATTCGGGTCCGCCAGTTAGCT

GAACTCCTCTCTCTGCCACCGACAGGCATCCAGCAAAGTTTAGGAAAATTAGCCCAGAAGTATGAAAAGGACCCA

GATTCCAGTTTGGCTTTGATTGAGACAAGTGGTGCTTATAGATTGGTGACCAAGCCTCAATTTGCAGAGATTTTGA

AGGAATACTCTAAGGCGCCTATCAACCAGAGCTTGTCTCGGGCTGCCCTTGAGACCTTGTCCATTATTGCCTACAA

ACAGCCGATTACGCGGATAGAAATTGATGCCATCCGTGGAGTTAACTCGAGTGGAGCCTTGGCAAAGTTGCAGGC

TTTTGACCTGATAAAGGAAGACGGGAAAAAGGAAGTATTGGGGCGCCCCAACCTCTATGTGACTACGGATTATTT

CCTAGATTACATGGGGATAAACCATTTAGAAGAATTACCAGTGATTGATGAGCTTGAGATTCAAGCCCAAGAAAG

CCAATTATTTGGTGAAAGGATAGAAGAAGATGAGAATCAATAA

4113.1

ATGGATACGATGATTAGTAGATTTTTTCGCCATTTATTTGAAGCCTTAAAAAGTTTGAAACGAAATGGTTGGATGA

CAGTAGCTGCTGTCAGTTCAGTCATGATTACTTTGACCTTGGTGGCAATATTTGCATCTGTTATTTTCAATACAGCG

AAACTAGCTACAGATATTGAAAATAATGTCCGTGTAGTAGTTTATATCCGAAAGGATGTGGAAGATAATAGTCAG

ACAATTGAAAAAGAAGGTCAAACTGTTACAAATAATGACTACCACAAGGTATATGATTCTTTGAAGAACATGTCT

ACGGTTAAAAGTGTTACCTTTTCAAGTAAAGAAGAACAATATGAAAAATTAACCGAGATAATGGGAGATAACTGG

AAAATCTTTGAAGGAGATGCCAATCCTCTCTATGATGCCTATATTGTAGAGGCAAACACTCCAAATGATGTAAAA

ACTATAGCCGAAGATGCTAAAAAAATTGAAGGTGTCTCTGAGGTTCAAGATGGCGGTGCCAATACAGAAAGACTC

TTCAAGTTAGCTTCATTTATCCGTGTTTGGGGACTAGGGATTGCTGCTTTGTTAATTTTTATCGCAGTTTTCTTGAT

TTCAAATACCATTCGTATTACCATTATTTCCCGCAGTCGCGAAATTCAAATCATGCGCTTGGTCGGAGCTAAAAAC

AGTTATATCCGTGGACCGTTCTTGTTAGAAGGAGCCTTTATCGGTTTATTGGGAGCTATCGCACCATCTGTTTTGGT

CTTTATTGTTTATCAAATTGTTTACCAATCTGTCAACAAATCGTTGGTAGGGCAAAATCTATCCATGATTAGTCCA

GATTTATTTAGTCCGTTGATGATTGCCCTACTATTTGTGATTGGGGTTTTCATTGGTTCATTGGGATCAGGAATATC

CATGCGCCGATTCTTGAAGATTTAG

4117.1

ATGAAGAAAGTAAGATTTATTTTTTTAGCTCTGCTATTTTTCTTAGCTAGTCCAGAGGGTGCAATGGCTAGTGATG

GTACTTGGCAAGGAAAACAGTATCTGAAAGAAGATGGCAGTCAAGCAGCAAATGAGTGGGTTTTTGATACTCATT

ATCAATCTTGGTTCTATATAAAAGCAGATGCTAACTATGCTGAAAATGAATGGCTAAAGCAAGGTGACGACTATTT

TTACCTCAAATCTGGTGGCTATATGGCCAAATCAGAATGGGTAGAAGACAAGGGAGCCTTTTATTATCTTGACCAA

GATGGAAAGATGAAAAGAAATGCTTGGGTAGGAACTTCCTATGTTGGTGCAACAGGTGCCAAAGTAATAGAAGAC

TGGGTCTATGATTCTCAATACGATGCTTGGTTTTATATCAAAGCAGATGGACAGCACGCAGAGAAAGAATGGCTC

CAAATTAAAGGGAAGGACTATTATTTCAAATCCGGTGGTTATCTACTGACAAGTCAGTGGATTAATCAAGCTTATG

TGAATGCTAGTGGTGCCAAAGTACAGCAAGGTTGGCTTTTTGACAAACAATACCAATCTTGGTTTTACATCAAAGA

AAATGGAAACTATGCTGATAAAGAATGGATTTTCGAGAATGGTCACTATTATTATCTAAAATCCGGTGGCTACATG

GCAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTTTTATCTCAAATTTGATGGGAAAATGGCTGAAAAAGAA

TGGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTCAAATCCGGTGGTTACATGACAGCCAATGAATGGATTT

GGGATAAGGAATCTTGGTTTTATCTCAAATCTGATGGGAAAATAGCTGAAAAAGAATGGGTCTACGATTCTCATA

GTCAAGCTTGGTACTACTTCAAATCCGGTGGTTACATGACAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTT

TTACCTCAAATCTGATGGGAAAATAGCTGAAAAAGAATGGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTC

AAATCTGGTGGCTACATGGCGAAAAATGAGACAGTAGATGGTTATCAGCTTGGAAGCGATGGTAAATGGCTTGGA

GGAAAAACTACAAATGAAAATGCTGCTTACTATCAAGTAGTGCCTGTTACAGCCAATGTTTATGATTCAGATGGTG

AAAAGCTTTCCTATATATCGCAAGGTAGTGTCGTATGGCTAGATAAGGATAGAAAAAGTGATGACAAGCGCTTGG

CTATTACTATTTCTGGTTTGTCAGGCTATATGAAAACAGAAGATTTACAAGCGCTAGATGCTAGTAAGGACTTTAT

CCCTTATTATGAGAGTGATGGCCACCGTTTTTATCACTATGTGGCTCAGAATGCTAGTATCCCAGTAGCTTCTCAT

CTTTCTGATATGGAAGTAGGCAAGAAATATTATTCGGCAGATGGCCTGCATTTTGATGGTTTTAAGCTTGAGAATC

CCTTCCTTTTCAAAGATTTAACAGAGGCTACAAACTACAGTGCTGAAGAATTGGATAAGGTATTTAGTTTGCTAAA

CATTAACAATAGCCTTTTGGAGAACAAGGGCGCTACTTTTAAGGAAGCCGAAGAACATTACCATATCAATGCTCTT

TATCTCCTTGCCCATAGTGCCCTAGAAAGTAACTGGGGAAGAAGTAAAATTGCCAAAGATAAGAATAATTTCTTTG

GCATTACAGCCTATGATACGACCCCTTACCTTTCTGCTAAGACATTTGATGATGTGGATAAGGGAATTTTAGGTGC

AACCAAGTGGATTAAGGAAAATTATATCGATAGGGGAAGAACTTTCCTTGGAAACAAGGCTTCTGGTATGAATGT

GGAATATGCTTCAGACCCTTATTGGGGCGAAAAAATTGCTAGTGTGATGATGAAAATCAATGAGAAGCTAGGTGG

CAAAGATTAG

4119.2

ATGAAAAAAGTATTACAAAAATATTGGGCATGGGCTTTTGTGGTCATCCCCCTCTTGTTACAAGCAATTTTCTTCT

ATGTGCCGATGTTTCAAGGAGCCTTTTACAGTTTTACCAACTGGACAGGATTGACTTATAACTACAAATTTGTTGG

CTTAAACAACTTTAAGCTCCTCTTCATGGATCCAAAATTCATGAATGCGATTGGCTTTACCGCAATCATTGCGATT

GCCATGGTGGTTGGTGAGATTGCACTCGGGATCTTCATTGCGCGTGTCTTGAATTCTAAAATCAAAGGCCAAACCT

TCTTCCGTGCTTGGTTCTTCTTCCCAGCTGTTTTATCTGGTTTGACAGTGGCTTTGATCTTCAAGCAAGTCTTCAAC

TACGGTCTTCCAGCGATTGGAAATGCCCTTCATATTGAATTTTTCCAAACCAGTCTTTTAGGGACTAAGTGGGGAG

CAATCTTTGCGGCTGTCTTTGTCCTTCTTTGGCAAGGGGTGGCTATGCCCATCATCATCTTCCTAGCTGGTTTGCAA

TCTATTCCAACTGAGATTACAGAGGCAGCAAGGATTGATGGTGCGACTAGCAAGCAAGTTTTCTGGAACATTGAA

TTGCCTTACTTGCTACCAAGTGTCTCTATGGTCTTTATCCTAGCCCTAAAAGGTGGGCTGACTGCCTTTGACCAAGT

CTTTGCCATGACCGGTGGTGGTCCAAACAATGCCACAACCTCACTTGGGCTCTTGGTTTATAACTATGCCTTTAAA

AACAACCAATTCGGTTATGCCAATGCCATTGCCGTAATCTTGTTCTTCTTAATTGTAGTGATTTCGATCATCCAATT

GAGAGTATCTAAG?AAATTTGAAATTTAA

4119.3

ATGATGAAACAAGATGAAAGAAAAGCCCTGATTGGCAAATACATTCTATTGATTCTAGGATCGGTTCTGATTTTAG

TGCCGCTCCTTGCTACCCTCTTTAGTTCCTTCAAACCCACTAAGGATATTGTAGATAATTTCTTTGGCTTTCCAACC

AACTTCACATGGGACAACTTTAGCCGTCTCTTAGCTGATGGGATTGGAGGCTATTATTGGAACTCTGTCGTCATCA

CTGTCTTGTCTTTACTTGCAGTAATGATCTTTATCCCTATGGCAGCCTACTCCATCGCTCGCAATATGAGTAAAAG

AAAAGCCTTTACCATCATGTATACCCTCTTAATCCTCGGAATCTTCGTACCTTTCCAAGTCATCATGATTCCGATTA

CGGTTATGATGAGTAAACTCGGTTTGGCTAATACCTTTGGTTTGATCTTGCTCTACTTGACCTATGCGATTCCACAG

ACCCTCTTTCTCTATGTTGGCTATATCAAAATCTCGATTCCAGAAAGTCTGGATGAAGCAGCAGAGATCGATGGGG

CTAATCAATTTACAACCTATTTCCGCATCATCTTCCCAATGATGAAACCGATGCATGCGACAACCATGATCATCAA

TGCCCTTTGGTTCTGGAATGACTTCATGTTGCCACTCCTTGTCTTGAACCGGGATTCCAAAATGTGGACTCTGCCTT

TGTTCCAATACAACTACGCAG?GCCAATATTTCAACGACTACGGACCAAGCTTTGCCTCTTACGTGGTCGGCATTAT

CAGTATCACCATTGTCTATCTCTTCTTCCAACG?CCATATCATTTCAGGAATGAGCAACGGGGCAGTGAAGTAA

4119.4

ATGAAAAGTATTCTTCAGAAAATGGGGGAGCATCCGATGCTGCTTCTTTTTCTTAGCTATAGTACTGTTATATCCA

TTCTTGCACAAAATTGGATGGGTCTTGTGGCTTCAGTAGGAATGTTTCTATTTACTATTTTCTTTTTGCACTATCAG

TCGATTTTATCCCATAAATTCTTTCGATTGATTTTGCAGTTTGTCTTGTTTGGTAGTGTCTTGTCAGCTGCTTTTGCC

AGTTTAGAACATTTCCAAATTGTGAAGAAATTTAACTATGCTTTTCTTTCACCCAATATGCAGGTGTGGCATCAGA

ACCGGGCAGAAGTGACCTTCTTTAATCCTAATTATTATGGAATTATTTGTTGTTTCTGTATTATGATTGCTTTCTAT

CTGTTTACAACGACCAAGTTGAATTGGTTGAAAGTATTCTGTGTGATTGCAGGCTTTGTTAATCTCTTTGGTTTGAA

CTTTACTCAAAATCGAACTGCCTTTCCTGCTATTATCGCTGGAGCAATTATCTATCTCTTTACGACTATTAAAAACT

GGAAGGCCTTTTGGCTTAGTATTGGGGTCTTCGCGATTGGTTTGAGTTTCCTCTTTTCTAGTGATTTGGGAGTTCGA

ATGGGTACTTTAGACTCTTCTATGGAAGAACGCATTTCTATCTGGGATGCTGGGATGGCCTTGTTTAAGCAAAATC

CTTTTTGGGGTGAAGGGCCATTGACCTATATGAACTCTTATCCTCGGATACATGCTCCTTATCATGAACATGCCCA

CAGTCTTTATATTGATACGATTCTGAGTTACGGAATTGTGGGGACTATTTTATTAGTTTTGTCTTCTGTTGCTCCTG

TTCGCTTGATGATGGATATGAGTCAGGAGTCGGGGAAACGTCCGATTATCGGCCTTTATCTATCTTTCCTTACAGT

GGTTGCTGTGCACGGAATTTTTGACTTGGCTCTCTTCTGGATTCAGTCAGGCTTTATTTTCTTGCTAGTTATGTGCA

GTATTCCATTGGAGCATCGAATGTTGGTATCGGACATGACGGATTAA

4120.1

ATGTCAAAGATGGATGTTCAGAAAATCATTGCACCGATGATGAAGTTTGTGAATATGCGTGGCATTATAGCTCTAA

AAGATGGGATGTTAGCAATTTTGCCATTGACAGTAGTTGGTAGTTTGTTCTTGATTATGGGACAATTGCCGTTCGA

AGGATTAAATAAGAGCATTGCTAGTGTTTTTGGAGCTAATTGGACAGAGCCGTTTATGCAAGTATATTCAGGAACT

TTTGCTATTATGGGTCTAATTTCTTGTTTTTCAATTGCCTATTCTTATGCTAAGAATAGCGGAGTAGAGGCTTTACC

AGCTGGAGTTCTATCTGTATCTGCATTCTTTATTTTGCTAAGATCATCTTATATCCCTAAACAAGGTGAGGCGATTG

GGGACGCTATTAGTAAAGTTTGGTTTGGAGGCCAAGGAATTATCGGTGCTATCATTATAGGTTTGGTAGTAGGAAG

TATTTATACCTTCTTTATAAAGAGAAAAATTGTTATTAAGATGCCAGAACAAGTTCCACAAGCTATTGCCAAACAG

TTTGAAGCAATGATTCCAGCATTTGTAATTTTCTTATCTTCTATGATTGTATATATTTTAGCGAAGTCATTGACTAA

TGGCGGAACATTCATAGAAATGATTTATTCTGCTATTCAAGTTCCGTTGCAAGGTTTAACTGGATCTTTGTATGGT

GCTATTGGAATTGCATTCTTTATATCATTTTTGTGGTGGTTTGGTGTTCATGGGCAATCGGTAGTAAATGGAGTAGT

GACAGCTCTGCTTTTATCTAATCTTGATGCTAATAAAGCTATGTTAGCCTCTGCTAATCTATCATTAGAAAATGGT

GCACATATTGTTACTCAACAATTTTTAGATTCATTTTTAATTCTATCAGGTTCAGGGATTACGTTTGGTCTTGTAGT

TGCCATGCTTTTTGCAGCAAAATCAAAACAATACCAAGCCTTAGGAAAAGTTGCAGCTTTTCCAGCAATATTTAAC

GTAAATGAGCCAGTTGTATTTGGATTTCCGATTGTCATGAATCCAGTTATGTTTGTACCTTTCATTCTTGTTCCTGT

ACTTGCAGCTGTGATAGTATATGGAGCTATTGCAACAGGTTTCATGCAGCCATTCTCAGGGGTAACATTGCCTTGG

AGTACACCAGCTATTTTATCAGGATTTTTGGTGGGTGGATGGCAAGGAGTTATTACTCAGCTGGTGATATTAGCGA

TGTCTACATTGGTTTATTTTCCATTCTTTAAAGTACAGGATCGTTTAGCTTACCAAAATGAAATCAAACAATCTTAG

4121.2

ATGAAGAAAAAGGACTTAGTAGACCAACTAGTCTCAGAGATCGAGACGGGGAAAGTCAGGACACTTGGGAATATA

CGGTCATGGAGCTTCAGGTAAATCAACCTTTGCACAGGAATTGTACCAAGCTTTAGATTCTACTACAGTAAATTTG

CTAGAGACAGATCCTTATATCACCTCAGGACGCCATCTGGTAGTACCCAAGGACGCGCCGAATCAAAAGGTGACA

GCCAGTCTGCCAGTGGCGCATGAACTGGAGAGTTTGCAGAGAGATATCCTTgCTTGCAGGCGGGTATGGATGTCTT

GA

4122.1

ATGAAGAAAAGATACCTAGTCTTGACAGCTTTGCTAGCCTTGAGTCTAGCAGCTTGTTCACAAGAAAAAACAAAA

AATGAAGATGGAGAAACTAAGACAGAACAGACAGCCAAAGCTGATGGAACAGTCGGTAGTAAGTCTCAAGGAGC

TGCCCAGAAGAAAGCAGAAGTGGTCAATAAAGGTGATTACTACAGCATTCAAGGGAAATACGATGAAATCATCGT

AGCCAACAAACACTATCCATTGTCTAAAGACTATAATCCAGGGGAAAATCCAACAGCCAAGGCAGAGTTGGTCAA

ACTCATCAAAGCGATGCAAGAGGCAGGTTTCCCTATTAGTGATCATTACAGTGGTTTTAGAAGTTATGAAACTCAG

ACCAAGCTCTATCAAGATTATGTCAACCAAGATGGAAAGGCAGCAGCTGACCGTTACTCTGCCCGTCCTGGCTAT

AGCGAACACCAGACAGGCTTGGCCTTTGATGTGATTGGGACTGATGGTGATTTGGTGACAGAAGAAAAAGCAGCC

CAATGGCTCTTGGATCATGCAGCTGATTATGGCTTTGTTGTCCGTTATCTCAAAGGCAAGGAAAAGGAAACAGGCT

ATATGGCTGAAGAATGGCACCTGCGTTATGTAGGAAAAGAAGCTAAAGAAATTGCTGCAAGTGGTCTCAGTTTGG

AAGAATACTATGGCTTTGAAGGCGGAGACTACGTCGATTAA

4125.6

ATGCGTAAATTCTTAATTATTTTGTTGCTACCAAGTTTTTTGACCATTTCAAAAGTCGTTAGCACAGAAAAAGAAG

TCGTCTATACTTCGAAAGAAATTTATTACCTTTCACAATCTGACTTTGGTATTTATTTTAGAGAAAAATTAAGTTCT

CCCATGGTTTATGGAGAGGTTCCTGTTTATGCGAATGAAGATTTAGTAGTGGAATCTGGGAAATTGACTCCCAAAA

CAAGTTTTCAAATAACCGAGTGGCGCTTAAATAAACAAGGAATTCCAGTATTTAAGCTATCAAATCATCAATTTAT

AGCTGCGGACAAACGATTTTTATATGATCAATCAGAGGTAACTCCAACAATAAAAAAAGTATGGTTAGAATCTGA

CTTTAAACTGTACAATAGTCCTTATGATTTAAAAGAAGTGAAATCATCCTTATCAGCTTATTCGCAAGTATCAATC

GACAAGACCATGTTTGTAGAAGGAAGAGAATTTCTACATATTGATCAGGCTGGATGGGTAGCTAAAGAATCAACT

TCTGAAGAAGATAATCGGATGAGTAAAGTTCAAGAAATGTTATCTGAAAAATATCAGAAAGATTCTTTCTCTATTT

ATGTTAAGCAACTGACTACTGGAAAAGAAGCTGGTATCAATCAAGATGAAAAGATGTATGCAGCCAGCGTTTTGA

AACTCTCTTATCTCTATTATACGCAAGAAAAAATAAATGAGGGTCTTTATCAGTTAGATACGACTGTAAAATACGT

ATCTGCAGTCAATGATTTTCCAGGTTCTTATAAACCAGAGGGAAGTGGTAGTCTTCCTAAAAAAGAAGATAATAA

AGAATATTCTTTAAAGGATTTAATTACGAAAGTATCAAAAGAATCTGATAATGTAGCTCATAATCTATTGGGATAT

TACATTTCAAACCAATCTGATGCCACATTCAAATCCAAGATGTCTGCCATTATGGGAGATGATTGGGATCCAAAAG

AAAAATTGATTTCTTCTAAGATGGCCGGGAAGTTTATGGAAGCTATTTATAATCAAAATGGATTTGTGCTAGAGTC

TTTGACTAAAACAGATTTTGATAGTCAGCGAATTGCCAAAGGTGTTTCTGTTAAAGTAG

CTCATAAAATTGGAGATGCGGATGAATTTAAGCATGATACGGGTGTTGTCTATGCAGATTCTCCATTTATTCTTTCT

ATTTTCACTAAGAATTCTGATTATGATACGATTTCTAAGATAGCCAAGGATGTTTATGAGGTTCTAAAATGA

4125.7

ATGAAAAAACAAAATAATGGTTTAATTAAAAATCCTTTTCTATGGTTATTATTTATCTTTTTCCTTGTGACAGGATT

CCAGTATTTCTATTCTGGGAATAACTCAGGAGGAAGTCAGCAAATCAACTATACTGAGTTGGTACAAGAAATTAC

CGATGGTAATGTAAAAGAATTAACTTACCAACCAAATGGTAGTGTTATCGAAGTTTCTGGTGTCTATAAAAATCCT

AAAACAAGTAAAGAAGAAACAGGTATTCAGTTTTTCACGCCATCTGTTACTAAGGTAGAGAAATTTACCAGCACT

ATTCTTCCTGCAGATACTACCGTATCAGAATTGCAAAAACTTGCTACTGACCATAAAGCAGAAGTAACTGTTAAGC

ATGAAAGTTCAAGTGGTATATGGATTAATCTACTCGTATCCATTGTGCCATTTGGAATTCTATTCTTCTTCCTATTC

TCTATGATGGGAAATATGGGAGGAGGCAATGGCCGTAATCCAATGAGTTTTGGACGTAGTAAGGCTAAAGCAGCA

AATAAAGAAGATATTAAAGTAAGATTTTCAGATGTTGCTGGAGCTGAGGAAGAAAAACAAGAACTAGTTGAAGTT

GTTGAGTTCTTAAAAGATCCAAAACGATTCACAAAACTTGGAGCCCGTATTCCAGCAGGTGTTCTTTTGGAGGGAC

CTCCGGGGACAGGTAAAACTTTGCTTGCTAAGGCAGTCGCTGGAGAAGCAGGTGTTCCATTCTTTAGTATCTCAGG

TTCTGACTTTGTAGAAATGTTTGTCGGAGTTGGAGCTAGTCGTGTTCGCTCTCTTTTTGAGGATGCCAAAAAAGCA

GCACCAGCTATCATCTTTATCGATGAAATTGATGCTGTTGGACGTCAACGTGGAGTCGGTCTCGGCGGAGGTAATG

ACGAACGTGAACAAACCTTGAACCAACTTTTGATTGAGATGGATGGTTTTGAGGGAAATGAAGGGATTATCGTCA

TCGCTGCGACAAACCGTTCAGATGTACTTGACCCTGCCCTTTTGCGTCCAGGACGTTTTGATAGAAAAGTATTGGT

TGGTCGTCCTGATGTTAAAGGTCGTGAAGCAATCTTGAAAGTTCACGCTAAGAATAAGC

CTTTAGCAGAAGATGTTGATTTGAAATTAGTGGCTCAACAAACTCCAGGCTTTGTTGGTGCTGATTTAGAGAATGT

CTTGAATGAAGCAGCTTTAGTTGCTGCTCGTCGCAATAAATCGATAATTGATGCTTCAGATATTGATGAAGCAGAA

GATAGAGTTATTGCTGGACCTTCTAAGAAAGATAAGACAGTTTCACAAAAAGAACGAGAATTGGTTGCTTACCAT

GAGGCAGGACATACCATTGTTGGTCTAGTCTTGTCGAATGCTCGCGTTGTCCATAAGGTTACAATTGTACCACGCG

GCCGTGCAGGCGGATACATGATTGCACTTCCTAAAGAGGATCAAATGCTTCTATCTAAAGAAGATATGAAAGAGC

AATTGGCTGGCTTAATGGGTGGACGTGTAGCTGAAGAAATTATCTTTAATGTCCAAACCACAGGAGCTTCAAACG

ACTTTGAACAAGCGACACAAATGGCACGTGCAATGGTTACAGAGTACGGTATGAGTGAAAAACTTGGCCCAGTAC

AATATGAAGGAAACCATGCTATGCTTGGTGCACAGAGTCCTCAAAAATCAATTTCAGAACAAACAGCTTATGAAA

TTGATGAAGAGGTTCGTTCATTATTAAATGAGGCACGAAATAAAGCTGCTGAAATTATTCAGTCAAATCGTGAAAC

TCACAAGTTAATTGCAGAAGCATTATTGAAATACGAAACATTGGATAGTACACAAATTAAAGCTCTTTACGAAAC

AGGAAAGATGCCTGAAGCAGTAGAAGAGGAATCTCATGCACTATCCTATGATGAAGTAAAGTCAAAAATGAATGA

CGAAAAATAA

4125.10

ATGAGGGAACCAGATTTTTTAAATCATTTTCTCAAGAAGGGATATTTCAAAAAGCATGCTAAGGCGGTTCTAGCTC

TTTCTGGTGGATTAGATTCCATGTTTCTATTTAAGGTATTGTCTACTTATCAAAAAGAGTTAGAGATTGAATTGATT

CTAGCTCATGTGAATCATAAGCAGAGAATTGAATCAGATTGGGAAGAAAAGGAATTAAGGAAGTTGGCTGCTGAA

GCAGAGCTTCCTATTTATATCAGCAATTTTTCAGGAGAATTTTCAGAAGCGCGTGCACGAAATTTTCGTTATGATT

TTTTTCAAGAGGTCATGAAAAAGACAGGTGCGACAGCTTTAGTCACTGCCCACCATGCTGATGATCAGGTGGAAA

CGATTTTTATGCGCTTGATTCGAGGAACTCGCTTGCGCTATCTATCAGGAATTAAGGAGAAGCAAGTAGTCGGAGA

GATAGAAATCATTCGTCCCTTCTTGCATTTTCAGAAAAAAGACTTTCCATCAATTTTTCACTTTGAAGATACATCA

AATCAGGAGAATCATTATTTTCGAAATCGTATTCGAAATTCTTACTTACCAGAATTGGAAAAAGAAAATCCTCGAT

TTAGGGATGCAATCTTAGGCATTGGCAATGAAATTTTAGATTATGATTTGGCAATAGCTGAATTATCTAACAATAT

TAATGTGGAAGATTTACAGCAGTTATTTTCTTACTCTGAGTCTACACAAAGAGTTTTACTTCAAACTTATCTGAATC

GTTTTCCAGATTTGAATCTTACAAAAGCTCAGTTTGCTGAAGTTCAG?CAGATTTTAAAATCTAAAAGCCAGTATCG

TCATCCGATTAAAAATGGCTATG?AATTGATAAAAGAGTACCAACAGTTTCAGATTTGTAAAATCAGTCCGCAGGCT

GATGAAAAGGAAGATGAACTTGTGTTACACTATCAAAATCAGGTAGCTTATCAAGGATATTTATTTTCTTTTGGAC

TTCCATTAGAAGGTGAATTAATTCAACAAATACCTGTTTCACGTGAAACATCCATACACATTGGTCATCGAAAAAC

AGGAGATGTTTTGATTAAAAATGGGCATAGAAAAAAACTCAGACGTTTATTTATTG

ATTTGAAAATCCCTATGGAAAAGAGAAACTCTGCTCTTATTATTGAGCAATTTGGTGAAATTGTCTCAATTTTGGG

AATTGCGACCAATAATTTGAGTAAAAAAACGAAAAATGATATAATGAACACTGTACTTTATATAGAAAAAATAGA

TAGGTAA

4126.1

ATGAAGCGTTCTTCTCTTTTAGTTAGAATGGTTATTTCCATCTTTCTGGTCTTTCTCATTCTCCTAGCTCTGGTTGGA

ACTTTCTACTATCAATCAAGTTCTTCAGCCATTGAGGCCACCATTGAGGGCAACAGCCAAACGACCATCAGCCAG

ACTAGCCACTTTATTCAGTCTTATATCAAAAAACTAGAAACCACCTCGACTGGTTTGACCCAGCAGACGGATGTTC

TGGCCTATGCTGAGAATCCCAGTCAAGACAAGGTCGAGGGAATCCGAGATTTGTTTTTGACCATCTTGAAGTCAGA

TAAGGACTTGAAAACTGTTGTGCTGGTGACCAAATCTGGTCAGGTCATTTCTACAGATGACAGTGTGCAGATGAA

AACTTCCTCTGATATGATGGCTGAGGATTGGTACCAAAAGGCCATTCATCAGGGAGCTATGCCTGTTTTGACTCCA

GCTCGTAAATCAGATAGTCAGTGGGTCATTTCTGTCACTCAAGAACTTGTTGATGCAAAGGGAGCCAATCTTGGTG

TGCTTCGTTTGGATATTTCTTATGAAACTCTGGAAGCCTATCTCAATCAACTCCAGTTGGGGCAGCAGGGCTTTGC

CTTCATTATCAATGAAAACCATGAATTTGTCTACCATCCTCAACACACAGTTTATAGTTCGTCTAGCAAAATGGAG

GCTATGAAACCCTACATCGATACAGGTCAGGGTTATACTCCTGGTCACAAATCCTACGTCAGTCAAGAGAAGATT

GCAGGAACTGATTGGACGGTGCTTGGCGTGTCATCATTGGAAAAGTTAGACCAGGTTCGGAGTCAGCTCTTGTGG

ACCTTGCTTGGGGCCAGTGTCACATCTCTTCTTGTCTGTCTCTGCTTAGTGTGGTTCAGTCTTAAACGCTGGATTGC

TCCTTTGAAGGATTTGAGAGAAACCATGTTGGAAATTGCTTCTGGTGCTCAAAATCTTCGTGCCAAGGAAGTTGGT

GCCTATGAACTGAGAGAAGTAACTCGCCAATTTAATGCTATGTTGGATCAGATTGATCAGTTGATGGTAGCTATTC

GTAGCCAGGAAGAAACGACCCGTCAGTACCAACTTCAAGCCCTTTCGAGCCAGATTAATCCACATTTCCTCTATAA

CACTTTGGACACCATCATCTGGATGGCTGAATTTCATGATAGTCAGCGAGTGGTGCAGGTGACCAAGTCCTTGGCA

ACCTATTTCCGCTTGGCGCTCAATCAAGGCAAGGACTTGATTTGTCTCTCTGACGAAATCAATCATGTCCGCCAGT

ATCTCTTTATCCAGAAACAACGCTATGGAGATAAGCTGGAATACGAAATTAATGAAAATGTTGCCTTTGATAATTT

AGTCTTACCCAAGCTGGTCCTACAACCCCTTGTAGAAAATGCTCTTTACCATGGCATTAAGGAAAAGGAAGGTCA

GGGCCATATTAAACTTTCTGTCCAGAAACAGGATTCGGGATTGGTCATCCGTATTGAGGATGATGGCGTTGGCTTC

CAAGATGCTGGTGATAGTAGTCAAAGTCAACTCAAACGTGGGGGAGTTGGTCTTCAAAATGTCGATCAACGGCTC

AAACTTCATTTTGGAGCCAATTACCATATGAAGATTGATTCTAGACCCCAAAAAGGGACGAAAGTTGAAATATAT

ATAAATAGAATAGAAACTAGCTAA

4126.7

ATGAAGCGTTCTTCTCTTTTAGTTAGAATGGTTATTTCCATCTTTCTGGTCTTTCTCATTCTCCTAGCTCTGGTTGGA

ACTTTCTACTATCAATCAAGTTCTTCAGCCATTGAGGCCACCATTGAGGGCAACAGCCAAACGACCATCAGCCAG

ACTAGCCACTTTATTCAGTCTTATATCAAAAAACTAGAAACCACCTCGACTGGTTTGACCCAGCAGACGGATGTTC

TGGCCTATGCTGAGAATCCCAGTCAAGACAAGGTCGAGGGAATCCGAGATTTGTTTTTGACCATCTTGAAGTCAGA

TAAGGACTTGAAAACTGTTGTGCTGGTGACCAAATCTGGTCAGGTCATTTCTACAGATGACAGTGTGCAGATGAA

AACTTCCTCTGATATGATGGCTGAGGATTGGTACCAAAAGGCCATTCATCAGGGAGCTATGCCTGTTTTGACTCCA

GCTCGTAAATCAGATAGTCAGTGGGTCATTTCTGTCACTCAAGAACTTGTTGATGCAAAGGGAGCCAATCTTGGTG

TGCTTCGTTTGGATATTTCTTATGAAACTCTGGAAGCCTATCTCAATCAACTCCAGTTGGGGCAGCAGGGCTTTGC

CTTCATTATCAATGAAAACCATGAATTTGTCTACCATCCTCAACACACAGTTTATAGTTCGTCTAGCAAAATGGAG

GCTATGAAACCCTACATCGATACAGGTCAGGGTTATACTCCTGGTCACAAATCCTACGTCAGTCAAGAGAAGATT

GCAGGAACTGATTGGACGGTGCTTGGCGTGTCATCATTGGAAAAGTTAGACCAGGTTCGGAGTCAGCTCTTGTGG

ACCTTGCTTGGGGCCAGTGTCACATCTCTTCTTGTCTGTCTCTGCTTAGTGTGGTTCAGTCTTAAACGCTGGATTGC

TCCTTTGAAGGATTTGAGAGAAACCATGTTGGAAATTGCTTCTGGTGCTCAAAATCTTCGTGCCAAGGAAGTTGGT

GCCTATGAACTGAGAGAAGTAACTCGCCAATTTAATGCTATGTTGGATCAGATTGATCAGTTGATGGTAGCTATTC

GTAGCCAGGAAGAAACGACCCGTCAGTACCAACTTCAAGCCCTTTCGAGCCAGATTAATCCACATTTCCTCTATAA

CACTTTGGACACCATCATCTGGATGGCTGAATTTCATGATAGTCAGCGAGTGGTGCAGGTGACCAAGTCCTTGGCA

ACCTATTTCCGCTTGGCGCTCAATCAAGGCAAGGACTTGATTTGTCTCTCTGACGAAATCAATCATGTCCGCCAGT

ATCTCTTTATCCAGAAACAACGCTATGGAGATAAGCTGGAATACGAAATTAATGAAAATGTTGCCTTTGATAATTT

AGTCTTACCCAAGCTGGTCCTACAACCCCTTGTAGAAAATGCTCTTTACCATGGCATTAAGGAAAAGGAAGGTCA

GGGCCATATTAAACTTTCTGTCCAGAAACAGGATTCGGGATTGGTCATCCGTATTGAGGATGATGGCGTTGGCTTC

CAAGATGCTGGTGATAGTAGTCAAAGTCAACTCAAACGTGGGGGAGTTGGTCTTCAAAATGTCGATCAACGGCTC

AAACTTCATTTTGGAGCCAATTACCATATGAAGATTGATTCTAGACCCCAAAAAGGGACGAAAGTTGAAATATAT

ATAAATAGAATAGAAACTAGCTAA

4127.4

ATGTTTTTTAAATTATTAAGAGAAGCTCTTAAAGTCAAGCAGGTTCGATCAAAAATTTTATTTACAATTTTTATCGT

TTTGGTCTTTCGTATCGGAACTAGCATTACAGTTCCTGGTGTGAATGCCAATAGCTTGAATGCTTTAAGTGGATTAT

CCTTCTTAAACATGTTGAGCTTGGTGTCGGGGAATGCCCTAAAAAACTTTTCGATTTTTGCCCTAGGAGTTAGTCC

CTATATCACCGCTTCTATTGTTGTCCAACTCTTGCAAATGGATATTTTACCCAAGTTTGTAGAGTGGGGTAAACAA

GGGGAAGTAGGTCGAAGAAAATTGAATCAAGCTACTCGTTATATTGCTCTAGTTCTCGCTTTTGTGCAATCTATCG

GGATTACAGCTGGTTTTAATACCTTGGCTGGAGCTCAATTGATTAAAACTGCTTTAACTCCACAAGTTTTTCTGAC

GATTGGTATCATCTTAACAGCTGGTAGTATGATTGTCACTTGGTTGGGTGAGCAAATTACAGATAAGGGATACGGA

AACGGTGTTTCCATGATTATCTTTGCCGGGATTGTTTCCTCAATTCCAGAGATGATTCAGGGCATCTATGTGGACT

ACTTTGTGAACGTCCCAAGTAGCCGTATCACTTCATCTATCATTTTCGTAATCATTTTGATTATTACTGTATTGTTG

ATTATTTACTTTACAACTTATGTTCAACAAGCAGAATACAAAATTCCAATCCAATATACTAAGGTTGCACAAGGTG

CTCCATCTAGCTCTTACCTTCCGTTAAAAGTAAACCCTGCTGGAGTTATCCCTGTTATCTTTGCCAGTTCGATTACT

GCAGCGCCTGCGGCTATTCTTCAGTTTTTGAGTGCCACAGGTCATGATTGGGCTTGGGTAAGGGTAGCACAAGAGA

TGTTGGCAACTACTTCTCCAACTGGTATTGCCATGTATGCTTTGTTGATTATTCTCTTTACATTCTTCTATACGTTTG

TACAGATTAATCCTGAAAAAGCAGCAGAGACCTACAAAAGAGTGGTGCCTATATCCATGGAGTTCGTCCTGGTAA

AGGTACAGAAGAATATATGTCTAAACTTCTTCGTCGTCTTGCAACTGTTGGTTCCCTCTTCCTTGGTGTGA

4127.5

ATGGATATTAGACAAGTTACTGAAACCATCGCCATGATTGAGGAGCAAAACTTCGATATTAGAACCATTACCATG

GGGATTTCTCTTTTGGACTGTATCGATCCAGATATCAATCGTGCTGCGGAGAAAATCTATCAAAAAATTACGACAA

AGGCGGCTAATTTAGTAGCTGTTGGTGATGAAATTGCGGCTG?AGTTGGGAATTCCTATCGTTAATAAGCGTGTATC

GGTGACACCTATTTCTCTGATTGGGGCAGCGACAGATGCGACGGACTACGTGGTTCTGGCAAAAGCGCTTGATAA

GGCTGCGAAAGAGATTGGTGTGGACTTTATTGGTGGTTTTTCTGCCTTAGTACAAAAAGGTTATCAAAAGGGAGAT

GAGATTCTCATCAATTCCATTCCTCGCGCTTTGGCTGAGACGGATAAGGTCTGCTCGTCAGTCAATATCGGCTCAA

CCAAGTCTGGTATTAATATGACGGCTGTGGCAGATATGGGACGAATTATCAAGGAAACAGCAAATCTTTCAGATA

TGGGAGTGGCCAAGTTGGTTGTATTCGCTAATGCTGTTGAGGACAATCCATTTATGGCGGGTGCCTTTCATGGTGT

TGGGGAAGCAGATGTTATCATCAATGTCGGAGTTTCTGGTCCTGGTGTTGTGAAACGTGCTTTGGAAAAAGTTCGT

GGACAGAGCTTTGATGTAGTAGCCGAAACAGTTAAGAAAACTGCCTTTAAAATCACTCGTATCGGTCAATTGGTTG

GTCAAATGGCCAGTGAGAGACTGGGTGTGGAGTTTGGTATTGTGGACTTGAGTTTGGCACCAACCCCTGCGGTTGG

AGACTCTGTGGCACGTGTCCTTGAGGAAATGGGGCTAGAAACAGTTGGCACGCATGGAACGACGGCTGCCTTGGC

CCTCTTGAACGACCAAGTTAAAAAGGGTGGAGTGATGGCCTGCAACCAAGTCGGTGGTTTATCTGGTGCCTTTATC

CCTGTTTCTGAGGATGAAGGAATGATTGCTGCAGTGCAAAATGGCTCTCTTAATTTAGAAAAACTAGAAGCTATGA

CGGCTATCTGTTCTGTTGGATTGGATATGATTGCCATCCCAGAAGATACGCCTGCTGAAACTATTGCGGCTATGAT

TGCGGATGAAGCAGCAATCGGTGTTATCAACATGAAAACAACAGCTGTTCGTATCATTCCCAAAGGAAAAGAAGG

CGATATGATTGAGTTTGGTGGTCTATTAGGAACTGCACCCGTTATGAAGGTTAATGGGGCTTCGTCTGTCGACTTC

ATCTCTCGCGGTGGACAAATCCCAGCACCAATTCATAGTTTTAAAAATTAA

4128.1

ATGACACAGATTATTGATGGGAAAGCTTTAGCGGCCAAATTGCAGGGGCAGTTGGCTGAAAAGACTGCAAAATTA

AAGGAAGAAACAGGTCTAGTGCCTGGTTTGGTAGTGATTTTGGTTGGGGACAATCCAGCCAGCCAAGTCTACGTT

CGCAACAAGGAGAGGTCAGCCCTTGCGGCTGGTTTCCGTAGCGAAGTAGTACGGGTTCCAGAGACCATTACTCAA

GAGGAATTGTTAGACCTGATTGCTAAATACAATCAGGATCCAGCTTGGCATGGGATTTTGGTTCAGTTGCCATTAC

CAAAACACATTGATGAAGAGGCGGTTCTATTGGCTATTGACCCAGAAAAGGATGTGGATGGTTTCCATCCTCTAA

ACATGGGGCGTCTTTGGTCTGGTCATCCAGTCATGATTCCTTCGACACCGGCAGGAATTATGGAAATGTTCCATGA

ATATGGGATTGACTTGGAAGGTAAAAATGCAGTCGTCATCGGTCGATCCAATATTGTCGGAAAACCTATGGCCCA

GCTTCTTTTGGCAAAGAATGCAACAGTAACCTTGACTCACTCACGTACTCATAATCTTTCCAAGGTGGCTGCAAAA

GCAGATATTCTGGTTGTTGCAATCGGTCGTGCCAAGTTTGTGACTGCTGACTTTGTCAAACCAGGTGCGGTAGTCA

TTGACGTTGGGATGAACCGCGATGAAAATGGTAAGCTCTGTGGGGATGTTGATTATGAGGCGGTTGCCCCACTTGC

TAGCCACATTACGCCAGTCCCTGGAGGTGTCGGTCCTATGACCATTACTATGCTGATGGAGCAAACCTATCAGGCA

GCACTTAGGACATTGGATAGAAAATAA

4128.2

ATGTCTAAATTTAATCGTATTCATTTGGTGGTACTGGATTCTGTAGGAATCGGTGCAGCACCAGATGCTAATAACT

TTGTCAATGCAGGGGTTCCAGATGGAGCTTCTGACACACTGGGACACATTTCAAAAACAGTTGGTTTGAATGTCCC

AAACATGGCTAAAATAGGTCTTGGAAATATTCCTCGTGAAACTCCTCTTAAGACTGTAGCAGCTGAAAGCAATCC

AACTGGATATGCAACAAAATTAGAGGAAGTATCTCTTGGTAAGGATACTATGACTGGACACTGGGAAATCATGGG

ACTCAACATTACTGAGCCTTTCGATACTTTCTGGAACGGATTCCCAGAAGAAATCCTGACAAAAATCGAAGAATTC

TCAGGACGCAAGGTTATTCGTGAAGCCAACAAACCTTATTCAGGAACGGCTGTTATCTATGATTTTGGACCACGTC

AGATGGAAACTGGAGAGTTGATTATCTATACTTCAGCTGACCCTGTTTTGCAGATTGCTGCCCACGAAGACATTAT

TCCTTTGGATGAATTGTACCGTATCTGTGAATACGCTCGTTCGATTACCCTTGAGCGTCCTGCCCTTCTTGGTCGCA

TCATTGCTCGCCCTTATGTAGGTGAACCAGGTAACTTCACTCGTACGGCAAACCGTCGTGACTTGGCTGTATCTCC

ATTTTTCCCAACTGTTTTGGATAAATTGAATGAGGCTGGTATCGATACTTATGCTGTGGGTAAAATCAACGATATC

TTTAACGGTGCTGGTATCAACCATGACATGGGTCACAACAAGTCAAATAGTCATGGAATTGATACACTATTGAAG

ACTATGGGACTTGCTGAGTTTGAAAAAGGATTCTCATTCACAAACCTAGTTGACTTTGATGCCCTTTACGGCCATC

GTCGTAATGCTCACGGTTACCGTGATTGCTTGCATGAGTTTGATGAACGCTTACCTGAAATTATCGCAGCTATGAG

AGAGAATGACCTTCTCTTGATTACTGCGGACCATGGAAATGACCCAACGTATGCAGGAACGGATCACACTCGGGA

ATATATTCCATTGTTGGCCTATAGCCCTGCCTTTAAAGGAAATGGTCTCATTCCAGTAGGACATTTTGCAGATATTT

CAGCGACTGTTGCCGATAACTTTGGTGTGGAAACTGCTATGATTGGGGAAAGTTTCTTAGATAAATTGGTATAA

4129.2

ATGTTTATTTCCATCAGTGCTGGAATTGTGACATTTTTACTAACTTTAGTAGAAATTCCGGCCTTTATCCAATTTTA

TAGAAAGGCGCAAATTACAGGCCAGCAGATGCATGAGGATGTCAAACAGCATCAGGCAAAAGCTGGGACTCCTA

CAATGGGAGGTTTGGTTTTCTTGATTACTTCTGTTTTGGTTGCTTTCTTTTTCGCCCTATTTAGTAGCCAATTCAGCA

ATAATGTGGGAATGATTTTGTTCATCTTGGTCTTGTATGGCTTGGTCGGATTTTTAGATGACTTTCTCAAGGTCTTT

CGTAAAATCAATGAGGGGCTTAATCCTAAGCAAAAATTAGCTCTTCAGCTTCTAGGTGGAGTTATCTTCTATCTTT

TCTATGAGCGCGGTGGCGATATCCTGTCTGTCTTTGGTTATCCAGTTCATTTGGGATTTTTCTATATTTTCTTCGCT

CTTTTCTGGCTAGTCGGTTTTTCAAACGCAGTAAACTTGACAGACGGTGTTGACGGTTTAGCTAGTATTTCCGTTGT

GATTAGTTTGTCTGCCTATGGAGTTATTGCCTATGTGCAAGGTCAGATGGATATTCTTCTAGTGATTCTTGCCATGA

TTGGTGGTTTGCTCGGTTTCTTCATCTTTAACCATAAGCCTGCCAAGGTCTTTATGGGTGATGTGGGAAGTTTGGCC

CTAGGTGGGATGCTGGCAGCTATCTCTATGGCTCTCCACCAAGAATGGACTCTCTTGATTATCGGAATTGTGTATG

TTTTTGAAACAACTTCTGTTATGATGCAAGTCAGTTATTTCAAACTGACAGGTGGTAAACGTATTTTCCGTATGAC

GCCTGTACATCACCATTTTGAGCTTGGGGGATTGTCTGGTAAAGGAAATCCTTGGAGCGAGTGGAAGGTTGACTTC

TTCTTTTCGGGAGTGGGACTTCTAGCAAGTCTCCTGACCCTAGCAATTTTATATTTGATGTAA

4133.1

TTGTTTAAGAAAAATAAAGACATTCTTAATATTGCATTGCCAGCTATGGGTGAAAACTTTTTGCAGATGCTAATGG

GAATGGTGGACAGTTATTTGGTTGCTCATTTAGGATTGATAGCTATTTCAGGGGTTTCAGTAGCTGGTAATATTAT

CACCATTTATCAGGCGATTTTCATCGCTCTGGGAGCTGCTATTTCCAGTGTTATTTCAAAAAGCATAGGGCAGAAA

GACCAGTCGAAGTTGGCCTATCATGTGACTGAGGCGTTGAAGATTACCTTACTATTAAGTTTCCTTTTAGGATTTTT

GTCCATCTTCGCTGGGAAAGAGATGATAGGACTTTTGGGGACGGAGAGGGATGTAGCTGAGAGTGGTGGACTGTA

TCTATCTTTGGTAGGCGGATCGATTGTTCTCTTAGGTTTAATGACTAGTCTAGGAGCCTTGATTCGTGCAACGCAT

AATCCACGTCTGCCTCTCTATGTTAGTTTTTTATCCAATGCCTTGAATATTCTTTTTTCAAGTCTAGCTATTTTTGTT

CTGGATATGGGGATAGCTGGTGTTGCTTGGGGGACAATTGTGTCTCGTTTGGTTGGTCTTGTGATTTTGTGGTCAC

AATTAAAACTGCCTTATGGGAAGCCAACTTTTGGTTTAGATAAGGAACTGTTGACCTTGGCTTTACCAGCAGCTGG

AGAGCGACTTATGATGAGGGCTGGAGATGTAGTGATCATTGCCTTGGTCGTTTCTTTTGGGACGGAGGCAGTTGCT

GGGAATGCAATCGGAGAAGTCTTGACCCAGTTTAACTATATGCCTGCCTTTGGCGTCGCTACGGCAACGGTCATGC

TGTTGGCCCGAGCAGTTGGAGAGGATGATTGGAAAAGAGTTGCTAGTTTGAGTAAACAAACCTTTTGGCTTTCTCT

GTTCCTCATGTTGCCCCTGTCCTTTAGTATATATGTCTTGGGTGTACCATTAACTCATCTCTATACGACTGATTCTC

TAGCGGTGGAGGCTAGTGTTCTAGTGACACTGTTTTCACTACTTGGGACCCCTATGACGACAGGAACAGTCATCTA

TACGGCAGTCTGGCAGGGATTAGGAAATGCACGCCTCCCTTTTTATGCGACAAGTATAGGAATGTGGTGTATCCGC

ATTGGGACAGGATATCTGATGGGGATTGTGCTTGGTTGGGGCTTGCCTGGTATTTGGGCAGGGTCTCTCTTGGATA

ATGGTTTTCGCTGGTTATTTCTACGCTATCGTTACCAGCGCTATATGAGCTTGAAAGGATAG

4135.2

ATGCAAACTCAAGAAAAACACTCGCAAGCAGCCGTTCTTGGCTTGCAGCACTTACTAGCCATGTACTCAGGATCT

ATCCTGGTTCCCATCATGATTGCGACAGCCCTTGGCTATTCAGCTGAGCAGTTGACCTACCTGATTTCTACAGATA

TCTTCATGTGTGGGGTGGCAACCTTCCTCCAACTCCAACTCAACAAATACTTTGGGATTGGACTCCCAGTCGTTCT

TGGAGTTGCATTCCAGTCGGTCGCTCCCTTGATTATGATTGGGCAAAGCCATGGTAGTGGCGCTATGTTTGGTGCC

CTTATCGCATCTGGGATTTACGTGGTTCTTGTTTCAGGCATCTTCTCAAAAGTAGCCAATCTCTTCCCATCTATCGT

AACAGGATCTGTTATTACCACGATTGGTTTAACCTTGATCCCTGTCGCTATTGGAAATATGGGAAATAACGTTCCA

GAGCCAACTGGTCAAAGTCTCTTGCTTGCAGCTATTACTGTTCTGATTATCCTCTTGATCAACATCTTTACCAAAG

GATTTATCAAGTCTATCTCTATTTTGATTGGTCTGGTTGTTGGAACTGCCATTGCTGCTACTATGGGCTTGGTGGAC

TTCTCTCCTGTTGCGGTAGCTCCACTTGTCCATGTCCCAACTCCACTCTACTTTGGGATGCCAACCTTTGAAATCTC

ATCTATTGTCATGATGTGTATCATCGCAACGGTGTCTATGGTTGAGTCAACTGGTGTTTATCTGGCCTTGTCTGATA

TCACAAAGGATCCAATCGACAGCACGCGCCTTCGCAACGGATACCGCGCAGAAGGTTTGGCCGTACTTCTCGGAG

GAATCTTTAACACCTTCCCTTACACCGGATTTTCACAAAACGTTGGTTTGGTTAAATTGTCAGGCATCAAAAAACG

CCTGCCAATCTACTACGCAGCTGGTTTCCTGGTTCTCCTTGGACTGCTTCCTAAGTTTGGCGCCCTTGCCCAAATCA

TTCCAAGCTCCGTCCTCGGTGGTGCCATGCTGGTAATGTTTGGTTTTGTATCAATTCAAGGGATGCAAATCCTCGC

CCGTGTTGACTTTGCTAACAATGAACACAACTTCCTTATCGCAG?CTGTTTCAATCGCTGCAGGTGTCGGTCTCAAC

AACAGTAATCTCTTTGTCAGCATGCCGACAGCCTTCCAAATGTTCTTCTCAAACGGAATCGTCGTAGCCAGCCTAC

TCGCTATTGTCCTCAATGCCGTATTAAATCATAAAAAGAAATAA

4136.2

ATGAAAGATAGAATAAAAGAATATTTACAAGACAAGGGAAAGGTGACTGTTAATGATTTGGCTCAGGCTTTGGGA

AAAGACAGTTCCAAGGATTTTCGTGAGTTGATTAAAACCTTGTCCTTAATGGAAAGAAAGCACCAAATTCGTTTTG

AAGAAGATGGTAGTCTGACATTAGAAATTAAGAAAAAACATGAGATTACCCTCAAGGGGATTTTTCATGCCCATA

AAAATGGCTTTGGCTTTGTTAGTCTGGAAGGCGAGGAGGACGACCTTTTTGTAGGGAAAAATGATGTCAACTATGC

TATTGATGGTGATACCGTCGAGGTAGTGATTAAGAAAGTCGCTGACCGCAATAAGGGAACAGCAGCAGAAGCCAA

AATTATTGATATCCTAGAACACAGTTTGACAACAGTTGTCGGGCAAATCGTTCTGGATCAGGAAAAACCTAAGTAT

GCTGGCTATATTCGTTCAAAAAATCAGAAAATCAGTCAACCGATTTATGTTAAGAAACCAGCCCTAAAATTAGAA

GGAACAGAAGTTCTCAAAGTCTTTATCGATAAATACCCAAGCAAGAAACATGATTTCTTTGTCGCGAGTGTTCTCG

ATGTAGTGGGACACTCAACGGATGTCGGAATTGATGTTCTTGAGGTCTTGGAATCAATGGACATTGTATCCGAGTT

TCCAGAAGCTGTTGTTAAGGAAGCAGAAAGTGTGCCTGATGCTCCGTCTCAAAAGGATATGGAAGGTCGTCTGGA

TCTAAGAGATGAAATTACCTTTACCATTGACGGTGCGGATGCCAAGGACTTGGACGATGCAGTGCATATCAAGGC

TCTGAAAAATGGCAATCTGGAGTTTGGGGTTCACATCGCAGATGTTTCTTATTATGTGACCGAGGGGTCTGCCCTT

GACAAGGAAGCCCTTAACCGTGCGACTTCTGTTTACGTGACAGACCGAGTGGTGCCAATGCTTCCAGAACGACTA

TCAAATGGCATCTGCTCTCTCAATCCCCAAGTTGACCGCCTGACCCAGTCTGCTATTAT

GGAGATTGATAAACATGGTCGTGTGGTCAACTATACCATTACACAAACAGTTATCAAGACCAGTTTTCGTATGACC

TATAGCGATGTCAATGATATCCTAGCTGGCGATGAAGAAAAGAGAAAAGAATATCATAAAATTGTATCAAGTATC

GAACTCATGGCCAAGCTTCATGAAACTTTAGAAAACATGCGTGTGAAACGTGGAGCTCTCAATTTTGATACCAATG

AAGCGAAGATTTTAGTGGATAAACAAGGTAAGCCTGTTGATATCGTTCTTCGGCAGCGTGGTATTGCCGAGCGGA

TGATTGAGTCTTTTATGTTGATGGCTAATGAAACAGTTGCCGAACATTTCAGCAAGTTGGATTTGCCTTTTATCTAT

CGAATTCACGAGGAGCCTAAGGCTGAAAAGGTTCAGAAGTTTATTGATTATGCTTCGAGTTTTGGCTTGCGCATTT

ATGGAACTGCCAGTGAGATTAGTCAGGAGGCACTTCAAGACATCATGCGTGCTGTTGAGGGAGAACCTTATGCAG

ATGTATTGTCCATGATGCTTCTTCGCTCTATGCAGCAGGCTCGTTATTCGGAGCACAATCACGGCCACTATGGACT

AGCTGCTGACTATTATACTCACTTTACCAGTCCAATTCGTCGTTATCCAGACCTTCTTGTTCACCGTATGATTCGGG

ATTACGGCCGTTCTAAGGAAATAGCAGAGCATTTTGAACAAGTGATTCCAGAGATTGCGACCCAGTCTTCCAACC

GTGAACGTCGTGCCATAGAAGCTGAGCGTGAAGTCGAAGCCATGAAAAAGGCTGAGTATATGGAAGAATACGTGG

GTGAAGAGTATGATGCAGTTGTATCAAGTATTGTCAAATTCGGTCTCTTTGTCGAATTGCCAAACACAGTTGAAGG

CTTGATTCACATCACTAATCTGCCTGAATTTTATCATTTCAATGAGCGTGATTTGACTCTTCGTGGAGAAAAATCA

GGTATCACTTTCCGAGTGGGTCAGCAGATCCGTATCCGTGTTGAAAGAGCGGATAAAATGACTGGAGAGATTGAT

TTTTCATTCGTACCTAGTGAGTTTGATGTGATTGAAAAAGGCTTGAAACAGTCTAGTCGT

AGTGGCAGAGGGCGTGATTCAAATCGTCGTTCGGATAAGAAGGAAGACAAGAGAAAATCAGGACGCTCAAATGA

TAAGCGTAAGCATTCACAAAAAGACAAGAAGAAAAAAGGAAAGAAACCTTTTTACAAGGAAGTAGCTAAGAAAG

GAGCCAAGCATGGCAAAGGGCGAGGGAAAGGTCGTCGCACAAAATAA

4137.2

ATGGGCACAACAGGATTTACAATAATTGACTTAATTATCTTGATTGTTTATTTACTTGCGGTGTTGGTTGCAGGTAT

CTATTTCTCTAAAAAAGAGATGAAAGGAAAAGAGTTCTTTAAAGGAGATGGTTCGGTTCCTTGGTATGTTACTTCG

GTATCCATTTTTGCCACAATGCTCAGTCCGATTTCCTTCTTGGGACTCGCTGGTAGCTCTTATGCAGGTAGCTGGAT

TTTATGGTTTGCTCAATTAGGGATGGTAGTAGCTATTCCACTGACAATTCGTTTTATCTTACCTATCTTTGCACGGA

TAGACATCGATACGGCATATGATTACTTGGATAAACGTTTTAATTCTAAAGCACTTCGTATTATTTCAGCACTCTT

GTTTATTATTTATCAATTGGGACGTATGTCTATCATTATGTACCTCCCATCAGCTGGTTTATCAGTATTGACAGGAA

TTGACATCAATATTTTGATTATTTTGATGGGTGTAGTTGCAATTGTTTATTCTTATACTGGTGGTCTAAAATCCGTA

TTATGGACAGACTTTATTCAAGGTGTGATTCTGATTAGTGGTGTCGTTTTAGCTTTATTTGTACTGATTGCTAATAT

TAAAGGTGGCTTTGGTGCAGTAGCAGAAACATTAGCAAACGGGAAATTCCTTGCTGCAAATGAAAAACTTTTCGA

TCCTAACTTGCTTTCAAACTCCATCTTTTTAATTGTGATGGGTTCAGGCTTTACAATCTTGTCTTCCTATGCTTCATC

TCAAGATTTGGTTCAACGTTTTACTACAACACAAAATATTAAGAAACTTAATAAGATGTTGTTCACAAACGGTGTT

TTGTCACTTGCAACTGCAACAGTCTTTTACTTGATTGGTACAGGCTTGTACGTATTCTATCAAGTACAAAATGCAG

ATAGTGCAGCTAGCAATATCCCTCAAGACCAAATCTTTATGTACTTTATTGCATACCAGTTACCAGTAGGTATCAC

AGGTTTGATCTTGGCAGCGATTTATGCAGCATCTCAATCAACTATTTCAACAGGTTTGAACTCTGTTGCAACTTCA

TGGACATTGGATATTCAAGATGTCATTTCTAAAAATATGTCAGACAATCGTCGTACGAAAATTGCACAATTCGTAT

CTCTAGCAGTAGGTTTATTCTCAATTGGTGTTTCCATTGTCATGGCTCACTCAGATATTAAATCTGCATACGAATGG

TTCAATAGTTTCATGGGACTTGTACTTGGTCTACTTGGTGGTGTATTTATTCTTGGATTTGTTTCTAAAAAAGCAAA

TAAACAAGGTGCTTATGCAGCGCTGATTGTATCAACCATCGTCATGGTATTTATTAAATACTTCCTTCCTCCAACA

GCTGTTAGCTACTGGGCATATTCATTGATTTCAATCTCTGTATCAGTAGTTTCAGGTTATATTGTATCTGTTCTTAC

TGGAAATAAAGTATCTGCACCTAAATATACAACGATTCATGATATTACAGAAATTAAAGCGGATTCAAGTTGGGA

AGTTCGTCACTAA

4138.1

ATGAAATTTAGTAAAAAATATATAGCAGCTGGATCAGCTGTTATCGTATCCTTGAGTCTATGTGCCTATGCACTAA

ACCAGCATCGTTCGCAGGAAAATAAGGACAATAATCGTGTCTCTTATGTGGATGGCAGCCAGTCAAGTCAGAAAA

GTGAAAACTTGACACCAGACCAGGTTAGCCAGAAAGAAGGAATTCAGGCTGAGCAAATTGTAATCAAAATTACAG

ATCAGGGCTATGTAACGTCACACGGTGACCACTATCATTACTATAATGGGAAAGTTCCTTATGATGCCCTCTTTAG

TGAAGAACTCTTGATGAAGGATCCAAACTATCAACTTAAAGACGCTGATATTGTCAATGAAGTCAAGGGTGGTTA

TATCATCAAGGTCGATGGAAAATATTATGTCTACCTGAAAGATGCAGCTCATGCTGATAATGTTCGAACTAAAGAT

GAAATCAATCGTCAAAAACAAGAACATGTCAAAGATAATGAGAAGGTTAACTCTAATGTTGCTGTAGCAAGGTCT

CAGGGACGATATACGACAAATGATGGTTATGTCTTTAATCCAGCTGATATTATCGAAGATACGGGTAATGCTTATA

TCGTTCCTCATGGAGGTCACTATCACTACATTCCCAAAAGCGATTTATCTGCTAGTGAATTAGCAGCAGCTAAAGC

ACATCTGGCTGGAAAAAATATGCAACCGAGTCAGTTAAGCTATTCTTCAACAGCTAGTGACAATAACACGCAATC

TGTAGCAAAAGGATCAACTAGCAAGCCAGCAAATAAATCTGAAAATCTCCAGAGTCTTTTGAAGGAACTCTATGA

TTCACCTAGCGCCCAACGTTACAGTGAATCAGATGGCCTGGTCTTTGACCCTGCTAAGATTATCAGTCGTACACCA

AATGGAGTTGCGATTCCGCATGGCGACCATTACCACTTTATTCCTTACAGCAAGCTTTCTGCCTTAGAAGAAAAGA

TTGCCAGAATGGTGCCTATCAGTGGAACTGGTTCTACAGTTTCTACAAATGCAAAACCTAATGAAGTAGTGTCTAG

TCTAGGCAGTCTTTCAAGCAATCCTTCTTCTTTAACGACAAGTAAGGAGCTCTCTTCAGCATCTGATGGTTATATTT

TTAATCCAAAAGATATCGTTGAAGAAACGGCTACAGCTTATATTGTAAGACATGGTGATCATTTCCATTACATTCC

AAAATCAAATCAAATTGGGCAACCGACTCTTCCAAACAATAGTCTAGCAACACCTTCTCCATCTCTTCCAATCAAT

CCAGGAACTTCACATGAGAAACATGAAGAAGATGGATACGGATTTGATGCTAATCGTATTATCGCTGAAGATGAA

TCAGGTTTTGTCATGAGTCACGGAGACCACAATCATTATTTCTTCAAGAAGGACTTGACAGAAGAGCAAATTAAG

GTGCGCAAAAACATTTAG

4139.1

ATGAAAAAAAGAGCAATAGTGGCAGTCATTGTACTGCTTTTGATTGGGCTGGATCAGTTGGTCAAATCCTATATCG

TCCAGCAGATTCCACTGGGTGAAGTGCGCTCCTGGATCCCCAATTTCGTTAGCTTGACCTACCTGCAAAATCGAGG

TGCAGCCTTTTCTATCTTACAAGATCAGCAGCTGTTATTCGCTGTCATTACTCTGGTTGTCGTGATAGGTGCCATTT

GGTATTTACATAAACACATGGAGGACTCATTCTGGATGGTCTTGGGTTTGACTCTAATAATCGCGGGTGGTCTTGG

AAACTTTATTGACAGGGTCAGTCAGGGCTTTGTTGTGGATATGTTCCACCTTGACTTTATCAACTTTGCAATTTTCA

ATGTGGCAGATAGCTATCTGACGGTTGGAGTGATTATTTTATTGATTGCAATGCTAAAAGAGGAAATAAATGGAA

ATTAA

4139.5

ATGAATACAAATCTTGCAAGTTTTATCGTTGGACTGATCATCGATGAAAACGACCGTTTTTACTTTGTGCAAAAGG

ATGGTCAAACCTATGCTCTTGCTAAGGAAGAAGGCCAACATACAGTAGGGGATACGGTCAAAGGTTTTGCATACA

CGGATATGAAGCAAAAACTCCGCCTGACAACCTTAGAAGTGACTGCCACTCAGGACCAATTTGGTTGGGGACGTG

TCACAGAGGTTCGTAAGGACTTGGGTGTCTTTGTGGATACAGGCCTTCCTGACAAGGAAATCGTTGTGTCACTCGA

TATTCTCCCTGAGCTCAAGGAACTCTGGCCTAAGAAGGGCGACCAACTCTACATCCGTCTTGAAGTGGATAAGAA

AGACCGTATCTGGGGCCTCTTGGCTTATCAAGAAGACTTCCAACGTCTTGCTCGTCCTGCCTACAACAACATGCAG

AACCAAAACTGGCCAGCCATTGTTTACCGTCTCAAGCTGTCAGGAACTTTTGTTTACCTACCAGAAAATAATATGC

TTGGTTTTATTCATCCTAGCGAGCGTTACGCAGAGCCACGTTTGGGGCAAGTATTAGATGCGCGCGTTATTGGTTT

CCGTGAAGTGGACCGCACTCTGAACCTCTCCCTCAAACCACGCTCCTTTGAAATGTTGGAAAACGATGCTCAGATG

ATTTTGACTTATTTGGAAAGCAATGGCGGTTTCATGACCTTAAATGACAAGTCATCTCCAGACGACATCAAGGCAA

CCTTTGGCATTTCTAAAGGTCAGTTCAAGAAAGCTTTAGGTGGTCTTATGAAGGCTGGTAAAATCAAGCAGGACCA

GTTTGGGACAGAGTTGATTTAG

4139.8

ATGAAAGATGTTAGTCTATTTTTATTGAAAAAAGTTTTCAAAAGCCGCTTAAACTGGATTGTCTTAGCTTTATTTGT

ATCTGTACTCGGTGTTACCTTTTATTTAAATAGTCAGACTGCAAACTCACACAGCTTGGAGAGCAGGTTGGAAAGT

CGCATTGCAGCCAACGAGAGGGCTATCAATGAAAATGAAGAGAAACTCTCCCAAATGTCTGATACCAGCTCGGAG

GAATACCAGTTTGCTAAAAATAATTTAGACGTGCAAAAAAATCTTTTGACGCGAAAGACAGAAATTCTGACTTTAT

TAAAAGAAGGGCGCTGGAAAGAAGCCTACTATTTGCAGTGGCAAGATGAAGAGAAGAATTATGAATTTGTATCAA

ATGACCCGACTGCTAGCCCTGGCTTAAAAATGGGGGTTGACCGCGAACGGAAGATTTACCAAGCCCTGTATCCCT

TGAACATAAAAGCACATACTTTGGAGTTTCCGACCCACGGGATTGATCAGATTGTCTGGATTTTAGAGGTTATCAT

CCCAAGTTTGTTTGTGGTTGCTATTATTTTTATGCTAACACAACTATTTGCAGAAAGATATCAAAATCATCTGGAC

ACAGCTCACTTATATCCTGTTTCAAAAGTGACATTTGCAATATCCTCTCTTGGAGTTGGAGTGGGATATGTAACTG

TGCTGTTTATCGGAATCTGTGGCTTTTCTTTTCTAGTGGGAAGTCTGATAAGTGGTTTTGGACAGTTAGATTATCCC

TACCCAATTTATAGCTTAGTGAATCAAGAAGTAACTATTGGGAAAATACAAGATGTATTATTTCCTGGCTTGCTCT

TAGCTTTCTTAGCCTTTATCGTCATTGTGGAAGTTGTGTACTTGATTGCTTACTTTTTCAAGCAAAAAATGCCTGTC

CTCTTTCTTTCACTCATTGGGATTGTTGGCTTATTGTTTGGTATCCAAACCATTCAGCCTCTTCAAAGGATTGCACA

TCTGATTCCCTTTACTTACTTGCGTTCAGTGGAGATTTTATCTGGAAGATTACCTAAGCAGATTGATAATGTCGATC

TAAATTGGAGCATGGGAATGGTCTTACTTCCTTGCCTGATTATCTTTTTGCTATTGGGAATTCTATTTATTGAAAGA

TGGGGAAGTTCACAGAAAAAAGAATTTTTTAATAGATTCTAG

4141.1

ATGATGAAGTTCATATTGGATATTGTTAGTACACCAGCTATTTTAGTAGCTTTAATTGCAATCTTAGGATTAGTTCT

TCAGAAGAAGAAATTACCTGATATTATTAAAGGTGGAATTAAGACCTTTGTTGGTTTCTTAGTTGTATCTGGTGGT

GCAGGAATTGTACAAAATTCTTTAAATCCATTTG?GTACCATGTTTGAGCATGCTTTTCATTTATCTGGCGTTGTGCC

GAATAATGAAGCAATTGTAGCTGTAGCTTTAACAACATATGGCTCAGCTACTGCAATGATTATGTTTGCAGGCATG

GTGTTCAATATCTTAATCGCTCGTTTTACTCGATTTAAATATATTTTTTTAACAGGGCACCACACTCTATATATGGC

ATGTATGATTGCGGTCATTTTATCAGTTGCTGGCTTTACTAGCTTGCCTCTCATCTTACTAGGAGGATTAGCACTCG

GTATTATTATGAGTATTTCCCCAGCATTTGTGCAAAAATATATGGTTCAATTAACTGGAAATGACAAGGTAGCTTT

AGGTCATTTCAGTTCTTTGGGATATTGGTTGAGTGGTTTTACTGGTAGCCTTATCGGTGACAAATCAAAATCAACA

GAGGACATTAAATTTCCAAAGAGTTTAGCTTTTTTACGTGATAGTACTGTTAGTATTACTTTATCCATGGCAGTTAT

TTACATTATTGTAGCTATCTTTGCAGGGTCAGAATATATAGAAAAAGAAATCAGTAGTGGTACAAGTGGTCTAGTT

TATGCTTTACAATTAGCAGGTCAATTTGCAGCAGGGGTATTTGTTATTTTAGCAGGTGTTCGCCTTATTTTGGGCGA

AATTGTTCCAGCCTTTAAAGGTATTTCAGAGCGTCTTGTACCTAATTCAAAACCTGCTTTGGATTGTCCGATTGTTT

ATACTTATGCACCCAATGCAGTTCTAATTGGATTTATCTCTAGTTTTGTTGGTGGTTTAGTAAGTATGGTAATTATG

ATTGCTTCAGGAACGGTTGTTATCTTACCAGGTGTTGTGCCTCATTTCTTCTGTGGAGCGACTGCAGGTGTCATTGG

GAATGCATCTGGTGGTGTTCGTGGAGCCACTATTGGAGCATTTTTACAAGGTATTTTAATCAGTTTTCTTCCAGTCT

TTTTAATGCCAGTTTTGGGAGGACTTGGTTTCCAAGGATCAACTTTCTCAGATGCAGATTTTGGTCTATCAGGAATT

ATTTTAGGAATGTTAAATCAATTTGGCTCACAAGCAGGCATTGTGATTGGTCTTGTTCTTATTCTAGCAGTTATGTT

TGGAGTATCCTTTATTAAAAAGCCATCTGCAACGGAGGAATAA

4142.3

ATGATTAAAACATTTCTCTCTGCCCTTTCGGTCATTCTCTTTTCTATCCCTATCATAACTTATTCTTTTTTCCCATCT

TCTAATCTTAACATTTGGCTATCTACCCAACCTATCTTGGCACAGATTTATGCCTTCCCCTTAGCTACTGCAACTAT

GGCTGCTATTTTAAGTTTCTTATTTTTTTTCCTATCTTTTTACAAGAAAAATAAACAAATACGGTTTTACTCTGGCA

TTTTGCTCTTACTATCGCTCATATTACTATTATTCGGAACAGATAAAACCCTTTCTTCTGCATCAAATAAGACTAAA

ACCTTAAAATTAGTAACTTGGAACGTCGCTAATCAAATAGAAGCACAACATATTGAGCGAATTTTTAGCCATTTTG

ACGCCGATATGGCTATATTCCCTGAACTAGCTACCAATATCAGAGGTGAGCAAGAAAACCAGAGAATCAAACTAT

TGTTTCATCAAGTTGGACTTTCTATGGCCAACTATGATATTTTCACTTCTCCACCTACCAATAGTGGAATAGCTCCT

GTGACTGTGATTGTCAAGAAAAGTTATGGTTTCTATACAGAAGCTAAAACTTTTCATACAACACGGTTCGGGACAA

TTGTATTACATTCGAGAAAACAAAATATACCAGATATCATTGCCTTGCATACTGCGCCTCCTCTGCCAGGTTTAAT

GGAAATCTGGAAGCAAGACTTAAACATCATTCATAATCAATTGGCTTCAAAATATCCAAAGGCTATTATTGCAGGT

GATTTTAATGCAACTATGCGTCATGGAGCACTTGCAAAAATAAGCTCTCATAGGGACGCATTAAATGCACTGCCA

CCTTTTGAAAGAGGAACTTGGAATAGCCAAAGTCCAAAACTTTTTAATGCAACAATAGATCATATTTTATTGCCTA

AAAACCACTACTATGTTAAAGATTTAGACATTGTAAGTTTTCAAAACTCTGATCATAGATGTATTTTTACAGAAAT

CACATTTTAA

4142.4

ATGAATCCAATCCAAAGATCTTGGGCTTATGTCAGCAGAAAGCGACTGAGAAGTTTTATTTTATTTCTGATTTTAT

TGGTCTTATTGGCCGGAATTTCAGCCTGTTTGACTCTGATGAAGTCCAACAAAACAGTAGAAAGCAATCTTTATAA

ATCACTCAATACATCTTTTTCTATTAAGAAGATAGAGAATGGTCAGACATTCAAGTTGTCAGACCTAGCATCTGTA

AGCAAGATTAAGGGGCTGGAAAATGTCTCTCCTGAACTTGAGACGGTCGCAAAACTAAAAGACAAGGAAGCAGTG

ACTGGCGAGCAGAGCGTGGAGCGTGATGATTTATCAGCTGCAGACAATAACTTGGTTAGCTTAACGGCTCTTGAG

GATTCATCCAAGGATGTAACCTTTACCAGTTCGGCTTTCAATCTAAAAGAAGGGCGACACCTTCAAAAAGGGGAT

TCCAAGAAAATCCTTATCCACGAAGAATTGGCTAAGAAGAACGGTCTTTCGCTTCATGACAAGATTGGCTTGGATG

CTGGTCAGTCTGAATCTGG?AAAAGGAGAAAACAGTAGAGTTTGAGATTATCGGCATCTTTTCTGGTAAAAAACAAG

AGAAATTCACAGGCTTGTCTTCTGACTTCAGTGAAAATCAAGTCTTTACAGACTATGAAAGTAGCCAAACCCTTTT

GGGCAATAGTGAAGCTCAAGTCAGTGCAGCACGCTTCTATGTAGAAAATCCTAAGGAAATGGACGGACTCATGAA

GCAGGTAGAAAACTTGGCCTTGGAAAATCAAGGCTACCAAGTCGAAAAGGAAAACAAGGCTTTTGAACAAATCAA

AGACTCAGTTGCAACTTTCCAAACCTTCCTGACCATCTTCCTTTATGGGATGTTGATAGCAGGAGCTGGAGCCTTA

ATTCTGGTTTTGTCTCTCTGGTTGAGAGAACGGGTCTATGAAGTGGGGATTTTACTTGCACTTGGAAAAGGCAAGA

GCTCGATCTTCCTACAATTCTGTTTAGAGGTAGTTTTGGTATCTCTTGGAGCTTTGCTTCCAGCATTTGTTGCAGGA

AACGCAATCACAACTTACCTACTCCAAACTCTACTAGCAAGTGGAGATCAGGCAAGCTTACAAGATACACTAGCC

AAAGCAAGCAGTTTATCAACTAGCATCTTATCTTTTGCAGAATCCTATGTTTTTCTAGTTCTGCTTAGTTGCTTATC

TGTAGCCCTTTGTTTCCTATTCTTATTTAGAAAATCACCGAAAGAAATTTTATCATCTATTAGTTAA

4142.5

ATGTTACACAACGCATTTGCCTATGTTACAAGGAAGTTTTTCAAATCGATTGTCATCTTCCTGATTATTCTCCTCAT

GGCGAGCTTGAGTTTGGTCGGCTTGTCAATCAAGGGAGCTACTGCCAAGGCTTCTCAGGAGACCTTTAAAAATATC

ACCAATAGCTTCTCCATGCAAATCAATCGTCGCGTCAACCAAGGAACGCCTCGTGGTGCTGGGAATATCAAGGGT

GAAGACATCAAAAAAATCACCGAAAACAAGGCCATTGAGTCTTATGTCAAACGTATCAACGCTATCGGAGATTTG

ACTGGATATGACCTGATTGAAACGCCAGAAACCAAGAAGAATCTCACTGCTGATCGTGCCAAGCGTTTTGGAAGT

AGCTTGATGATTACAGGTGTCAATGACTCCTCTAAAGAAGACAAGTTTGTCTCTGGTTCTTATAAACTAGTCGAAG

GAGAGCACTTAACCAACGACGACAAGGATAAAATCCTCTTGCACAAGGACTTGGCAGCCAAACACGGCTGGAAA

GTAGGGGACAAGGTTAAACTGGACTCTAATATCTACGATGCAGATAATGAAAAAGGAGCCAAGGAAACAGTTGA

AGTGACAATCAAGGGACTCTTTGATGGTCATAATAAGTCAGCAGTAACCTACTCACAAGAACTTTACGAAAACAC

AGCTATTACAGACATTCACACTGCTGCAAAACTTTATGGATACACAGAAGACACAGCCATTTATGGGGACGCAAC

CTTCTTTGTAACAGCAGACAAGAACTTGGATGATGTTATGAAAGAGTTGAATGGCATCAGTGGTATCAACTGGAA

GAGCTACACACTCGTCAAGAGCTCCTCTAACTACCCAGCTCTTGAGCAATCTATCTCTGGTATGTACAAGATGGCC

AACCTCCTCTTCTGGGGTAGCTTGAGCTTCTCAGTTCTCCTCCTTGCCCTCTTGCTCAGCCTTTGGATCAACGCCCG

TCGCAAGGAAGTGGGAATTCTCCTCTCTATCGGCCTCAAGCAGGCAAGTATCTTGGGTCA

ATTCATCACCGAATCTATCTTGATTGCTATCCCTGCTCTAGTTTCTGCTTACTTCCTAGCTAATTACACTGCCCGTG

CAATTGGAAACACTGTCCTTGCCAATGTGACTTCAGGTGTTGCCAAACAGGCTAGTAAGGCGGCTCAAGCCTCTA

ACCTTGGTGGTGGTGCAGAAGTAGATGGCTTTAGCAAGACCTTGTCGAGCCTAGACATTTCCATTCAGACATCAGA

CTTTATCATCATTTTTGTCCTTGCCTTGGTTCTAGTGGTTCTCGTTATGGCGCTTGCTTCAAGCAATCTCCTTAGAA

AACAACCAAAAGAGCTCTTGCTGGATGGTGAATAA

4144.1

ATGTCACAGGATAAACAAATGAAAGCTGTTTCTCCCCTTCTGCAGCGAGTTATCAATATCTCATCGATTGTCGGTG

GGGTTGGGAGTTTGATTTTCTGTATTTGGGCTTATCAGGCTGGGATTTTACAATCCAAGGAAACCCTCTCTGCCTTT

ATCCAGCAGGCAGGCATCTGGGGTCCACCTCTCTTTATCTTTTTACAGATTTTACAGACTGTCGTCCCTATCATTCC

AGGGGCCTTGACCTCGGTGGCTGGGGTCTTTATCTACGGGCACATCATCGGGACTATCTACAACTATATCGGCATC

GTGATTGGCTGTGCCATTATCTTTTATCTAGTGCGCCTATACGGAGCTGCCTTTGTCCAGTCTGTCGTCAGCAAGC

GCACCTACGACAAGTACATCGACTGGCTAGATAAGGGCAATCGTTTTGACCGCTTCTTTTATTTTTATGATGATTTG

GCCCATTAGCCCAGCTGACTTTCTCTGTATGCTGGCTGCCCTGACCAAGATGAGCTTCAAGCGCTACATGACCATC

ATCATTCTGACCAAACCCTTTACCCTCGTGGTTTATACCTACGGTCTGACCTATATTATTGACTTTTTCTGGCAAAT

GCTTTGA

4144.2

ATGAGAAATATGTGGGTTGTAATCAAGGAAACCTATCTTCGACATGTCGAGTCATGGAGTTTCTTCTTTATGGTGA

TTTCGCCGTTCCTCTTTTTAGGAATCTCTGTAGGAATTGGGCATCTCCAAGGTTCTTCTATGGCTAAAAATAATAAA

GTGGCAGTAGTGACAACAGTGCCATCTGTAGCAGAAGGACTGAAGAATGTAAATGGTGTTAACTTCGACTATAAA

GACGAAGCAAGTGCCAAAGAAGCAATTAAAGAAGAAAAATTAAAAGGTTATTTGACCATTGATCAAGAAGATAGT

GTTCTAAAGGCAGTTTATCATGGCGAAACATCGCTTGAAAATGGAATTAAATTTGAGGTTACAGGTACACTCAATG

AACTGCAAAATCAGCTTAATCGTTCAACTGCTTCCTTGTCTCAAGAGCAGGAAAAACGCTTAGCGCAGACAATTC

AATTCACAGAAAAGATTGATGAAGCCAAGGAAAATAAAAAGTTTATTCAAACAATTGCAGCAGGTGCCTTAGGAT

TCTTTCTTTATATGATTCTGATTACCTATGCGGGTGTAACAGCTCAGGAAGTTGCCAGTGAAAAAGGCACCAAAAT

TATGGAAGTCGTTTTTTCTAGCATAAGGGCAAGTCACTATTTCTATGCGCGGATGATGGCTCTGTTTCTAGTGATTT

TAACGCATATTGGGATCTATGTTGTAGGTGGTCTGGCTGCCGTTTTGCTCTTTAAAGATTTGCCATTCTTGGCTCAG

TCTGGTATTTTGGATCACTTGGGAGATGCTATCTCACTGAATACCTTGCTCTTTATTTTGATCAGTCTTTTCATGTA

CGTAGTCTTGGCAGCCTTCCTAGGATCTATGGTTTCTCGTCCTGAGGACTCAGGGAAAGCCTTGTCGCCTTTGATG

ATTTTGATTATGGGTGGTTTTTTTGGAGTGACAGCTCTAGGTGCAGCTGGTGACAATCTCCTCTTGAAGATTGGTTC

TTATATTCCCTTTATTTCGACCTTCTTTATGCCGTTTCGAACGATTAATGACTATGCGGGGGGAGCAGAAGCATGG

ATTTCACTTGCTATTACAGTGATTTTTGCGGTGGTAGCAACAGGATTTATCGGACGCATGTATGCTAGTCTCGTTCT

TCAAACGGATGATTTAGGGATTTGGAAAACCTTTAAACGTGCCTTATCTTATAAATAG

4144.3

ATGACAGAAACCATTAAATTGATGAAGGCTCATACTTCAGTGCGCAGGTTTAAAGAGCAAGAAATTCCCCAAGTA

GACTTAAATGAGATTTTGACAGCAGCCCAGATGGCATCATCTTGGAAGAATTTCCAATCCTACTCTGTGATTGTGG

TACGAAGTCAAGAGAAGAAAGATGCCTTGTATGAATTGGTACCTCAAGAAGCCATTCGCCAGTCTGCTGTTTTCCT

TCTCTTTGTCGGAGATTTGAACCGAGCAGAAAAGGGAGCCCGACTTCATACCGACACCTTCCAACCCCAAGGTGT

GGAAGGTCTCTTGATTAGTTCGGTCGATGCAGCTCTTGCTGGACAAAACGCCTTGTTGGCAGCTGAAAGCTTGGGC

TATGGTGGTGTGATTATCGGTTTGGTTCGATACAAGTCTGAAGAAGTGGCAGAGCTCTTTAACCTACCTGACTACA

CCTATTCTGTCTTTGGGATGGCACTGGGTGTGCCAAATCAACATCATGATATGAAACCGAGACTGCCACTAGAGA

ATGTTGTCTTTGAGGAAGAATACCAAGAACAGTCAACTGAGGCAATCCAAGCTTATGACCGTGTTCAGGCTGACT

ATGCTGGGGCGCGTGCGACCACAAGCTGGAGTCAGCGCCTAGCAGAACAGTTTGGTCAAGCTGAACCAAGCTCAA

CTAGAAAAAATCTTGAACAGAAGAAATTATTGTAG

4146.1

ATGTTAAAACTTATTGCTATTGTTGGAACAAATTCAAAACGTTCTACAAACCGTCAATTGCTTCAATACATGCAAA

AACACTTTACTGACAAAGCTGAAATTGAACTTGTTGAAATCAAGGCCATTCCTGTCTTCAACAAACCAGCTGACAA

GCAAGTACCTGCTGAAATATTGGAAATTGCTGCTAAAATCGAAGAGGCAGATGGCGTTATTATCGGTACTCCTGA

GTATGATCACTCTATTCCAGCTGTTTTGATGAGCGCTCTTGCTTGGTTGTCTTATGGTATTTACCCACTTTTGAACA

AACCAATCATGATTACAGGTGCTTCTTACGGTACGCTTGGTTCATCTCGTGCCCAATTGCAACTTCGTCAAATCTT

GAATGCTCCTGAAATCAAGGCAAATGTTCTTCCAGATGAATTCTTGCTCTCACACTCTCTTCAAGCATTTAACCCA

AGTGGCGACTTGGTTGACCTTGATGTTATCAAGAAATTGGATGCCATCTTTGATGACTTCCGTATCTTTGTAAAAA

TCACAGAAAAATTACGTAATGCACAAGAATTACTTCGCAAAGATGCTGAAGACTTTGACTGGGAAAATTTGTAA

4146.2

ATGAATACCTATCAATTAAATAATGGAGTAGAAATTCCAGTATTGGGATTTGGAACTTTTAAGGCTAAGGATGGA

GAAGAAGCCTATCGTGCAGTGTTAGAAGCCTTGAAGGCTGGTTATCGTCATATTGATACGGCGGCGATTTATCAGA

ATGAAGAAAGTGTTGGTCAAGCAATCAAAGATAGCGGAGTTCCACGTGAAGAAATGTTCGTAACTACCAAGCTTT

GGAATAGTCAGCAAACCTATGAGCAAACTCGTCAAGCTTTGGAAAAATCTATAGAAAAACTGGGCTTGGATTATT

TGGATTTGTATTTGATTCATTGGCCGAACCCAAAACCGCTCAGAGAAAATGACGCATGGAAAACTCGCAATGCGG

AAGTTTGGAGAGCGATGGAAGACCTCTATCAAGAAGGGAAAATCCGTGCTATCGGCGTTAGCAATTTTCTTCCCC

ATCATTTGGATGCCTTGCTTGAAACTGCAACTATCGTTCCTGCGGTCAATCAAGTTCGCTTGGCGCCAGGTGTGTA

TCAAGATCAAGTCGTAGCTTACTGTCGTGAAAAGGGAATTTTATTGGAAGCTTGGGGGCCTTTTGGACAAGGAGA

ACTGTTTGATAGCAAGCAAGTCCAAGAAATAGCAGCAAATCACGGAAAATCGGTTGCTCAGATAGCCTTGGCCTG

GAGCTTGGCAGAAGGATTTTTACCACTTCCAAAATCTGTCACAACCTCTCGTATTCAAGCTAATCTTGATTGCTTT

GGAATTGAACTGAGTCATGAGGAGAGAGAAACCTTAAAAACGATTGCTGTTCAATCGGGTGCTCCACGAGTTGAT

GATGTGGATTTCTAG

4147.1

ATGAGGTGCAAAATGCTTGATCCAATTGCTATTCAACTAGGACCCCTAGCCATTCGTTGGTATGCCTTATGTATTG

TGACAGGCTTGATTCTTGCGGTTTATTTGACCATGAAAGAAGCACCTAGAAAGAAGATCATACCAGACGATATTTT

AGATTTTATCTTAGTAGCCTTTCCCTTGGCTATTTTAGGAGCTCGTCTCTACTATGTTATTTTCCGATTTGATTACTA

TAGTCAGAATTTAGGAGAGATTTTTGCCATTTGGAATGGTGGTTTGGCCATTTACGGTGGTTTGATAACTGGGGCT

CTTGTGCTCTATATCTTTGCTGACCGTAAACTCATCAATACTTGGGATTTTCTAGATATTGCGGCGCCTAGCGTTAT

GATTGCTCAAAGTTTGGGGCGTTGGGGTAATTTCTTTAACCAAGAAGCTTATGGTGCAACAGTGGATAATCTGGAT

TATCTACCTGGCTTTATCCGTGACCAGATGTATATTGAGGGGAGCTACCGTCAACCGACTTTCCTTTATGAGTCTC

TATGGAATCTGCTTGGCTTTGCCTTGATTCTGATTTTTAGACGGAAATGGAAGAGTCTCAGACGAGGTCATATCAC

GGCCTTTTACTTGATTTGGTATGGTTTCGGTCGTATGGTTATCGAAGGTATGCGAACAGATAGTCTCATGTTCTTCG

GCTTTCGAGTGTCCCAATGGCTGTCAGTTGTCCTTATCGGTCTCGGTATAATGATCGTTATTTATCAAAATCGAAA

GAAGGCCCCTTACTATATTACAGAGGAGGAAAACTAA

4147.2

ATGGGTAAATTATCCTCAATCCTTTTAGGAACCGTTTCAGGTGCAGCTCTTGCCTTGTTTTTAACAAGTGATAAGG

GCAAACAAGTTTGCAGTCAGGCTCAAGATTTTCTAGATGATTTGAGAGAAGATCCGGAGTATGCCAAGGAGCAAG

TCTGTGAAAAACTGACAGAAGTTAAGGAGCAGGCTACAGATTTTGTTCTGAAAACAAAAGAACAGGTTGAGTCAG

GTGAAATCACTGTGGACAGTATACTTGCTCAAACTAAATCCTATGCTTTTCAAGCGACAGAAGCATCAAAAAATC

AATTAAATAATCTCAAGGAGCAATGGCAAGAAAAAGCCGAAGCTCTTGATGACTCAGAAGAGATTGTGATTGATA

TAACAGAAGAATAA

4147.3

ATGAAAACTAAATTGATCTTTTGGGGCTCTATGCTCTTTCTCCTCTCCCTCTCCATCCTTCTGACCATTTATCTGGC

TTGGATTTTCTATCCTATGGAGATTCAGTGGCTAAACTTAACGAATCGAGTCTATCTAAAACCAGAAACCATTCAA

TACAATTTTCATATCTTGATGAATTATCTGACCAATCCTTTTAGTCAGGTCTTACAGATGCCTGATTTTCGTTCGTC

AGCAGCTGGTCTGCACCATTTCGCAGTGGTCAAGAATCTCTTTCATTTGGTTCAGCTAGTAGCTCTAGTGACACTG

CCAAGTTTCTATGTCTTTGTCAATAGGATTGTGAAAAAGGACTTTTTGTCTCTTTATCGAAAAAGTCTCCTGGCTCT

AGTAGTCTTACCTGTGATGATTGGACTTGGGGGAGTTTTGATTGGTTTTGACCAATTCTTTACTCTTTTCCATCAAA

TTCTCTTTGTGGGAGATGATACCTGGCTTTTTGATCCAGCCAAGGATCCTGTTATTATGATTTTGCCAGAGACCTTC

TTTCTTCATGCCTTCCTCCTCTTTTTTGCCCTCTATGAAAACTTCTTTGGCTATCTGTATCTGAAAAGTCGTAGGAA

GTGA

4149.1

ATGACTTATCATTTTACTGAAGAATACGATATTATTGTAATTGGTGCGGGACACGCTGGGGTTG?AGGCTTCCTTGG

CCGCTAGCCGTATGGGCTGTAAGGTCCTGCTTGCGACCATCAATATTGAAATGCTGGCTTTCATGCCTTGTAATCC

CTCTATCGGTGGTTCTGCCAAGGGGATTGTCGTGCGTGAAGTCGATGCCCTCGGTGGCGAGATGGCCAAAACCATT

GACAAGACTTACATCCAGATGAAGATGCTAAACACAGGGAAGGGGCCAGCTGTCCGTGCCCTTCGTGCGCAGGCT

GACAAGGAACTTTACTCTAAGGAGATGCGCAAGACGGTTGAAAACCAAGAAAATCTGACCCTTCGTCAAACCATG

ATTGATGAGATTTTGGTGGAAGATGGCAAGGTTGTCGGTGTGCGTACAGCCACCCATCAAGAATATGCTGCTAAG

GCTGTTATTGTGACGACAGGGACTGCTCTCCGTGGGGAAATTATCATCGGAGACCTCAAGTACTCATCAGGTCCTA

ACCACAGCTTGGCTTCTATTAACCTAGCTGACAATCTCAAGGAACTGGGTCTCGAAATCGGTCGTTTCAAGACAGG

AACCCCTCCACGTGTCAAGGCTTCTTCTATCAATTACGATGTGACAGAAATTCAGCCAGGAGACGAAGTGCCTAAT

CATTTCTCATACACTTCACGTGATGAGGATTATGTCAAGGACCAAGTACCATGCTGGTTGACCTATACCAATGGTA

CCAGTCATGAGATTATCCAAAACAACCTCCACCGTGCGCCTATGTTTACAGGTGTGGTCAAGGGAGTGGGGCCTC

GTTACTGTCCGTCGATTGAAGACAAGATTGTGCGCTTTGCGGACAAGGAACGTCACCAACTCTTCCTTGAGCCAGA

AGGGCGCAATACTGAGGAAGTCTATGTGCAAGGACTTTCAACCAGTCTGCCTGAGGATGTCCAGCGTGACTTGGT

GCATTCCATCAAAGGTTTGGAAAATGCAGAGATGATGCGGACAGGTTATGCTATTGA

GTATGATATGGTCTTGCCTCATCAGTTGCGTGCGACTTTGGAAACCAAGAAAATCTCAGGTCTCTTCACTGCTGGT

CAGACAAATGGAACATCAGGTTACGAAGAGGCAGCAGGCCAAGGGATTATCGCGGGTATCAATGCGGCTCTGAA

AATCCAAGGCAAGCCTGAATTGATTTTGAAGCGCAGTGATGGTTATATCGGGGTGATGATCGACGACTTGGTGAC

CAAGGGAACCATTGAACCCTACCGTCTCTTGACCAGTCGTGCTGAATACCGTCTCATTCTTCGTCATGACAATGCT

GATATGCGCTTGACTGAGATGGGACGCGAGATTGGCCTTGTGGACGATGAACGCTGGGCTCGTTTTGAAATCAAG

AAAAATCAATTTGATAATGAGATGAAGCGCCTAGACAGTATCAAACTCAAGCCAGTCAAGGAAACCAATGCCAAG

GTTGAGGAGATGGGCTTCAAACCCTTGACCGATGCAGTGACAGCCAAGGAATTCCTTCGCCGTCCAGAAGTTTCTT

ACCAAGATGTGGTGGCCTTCATCGGACCAGCTGCAGAAGACTTGGATGACAAGATTATCGAATTGATTGAAACAG

AAATCAAGTATGAAGGCTATATTTCCAAAGCCATGGACCAGGTTGCCAAGATGAAACGCATGGAAGAAAAACGCA

TTCCGGCCAATATCGACTGGGATGACATTGATTCTATCGCAACCGAAGCCCGTCAGAAGTTCAAACTCATCAATCC

AGAAACCATCGGCCAAGCCAGCCGTATTTCGGGAGTAAACCCAGCAGATATTTCTATTTTGATGGTGTATCTGGAA

GGTAAAAATCGTAGTATTTCTAAAACTCTTCAAAAATCAAAATGA

4149.2

ATGAAAGTATTAGCTTTTGATACGTCCAGCAAGGCTCTTTCTCTGGCTATTTTAGAGGATAAGCAGGTTCTTGCCG

AGACGACGATTAATATTAAGAAAAATCACAGTATTACTCTTATGCCTGCCATCGATTTTTTGATGGCAAGTTTGGA

TTGGACACCCAAGGATTTGGACCGAATCGTGGTAGCTGAAGGGCCGGGTAGCTATACAGGCTTGCGAATTGCGGT

AGCAACTGCTAAGACCTTAGCTCACACCCTGAACATCGAGTTGGTTGGTATGTCGAGTCTCTTGGCTCTGGTGCCC

CATCAACAAGAAGGTTTGTTTGTCCCCTTGATGGATGCGCGTCGCAATAATGTTTATGCAGGATTTTATGAAAATG

CCAAACCTGTCATGGCAGAAGCGCACCTATCTTTTGAAGAGGTGCTAGAAAAAGTCAAGGGTACTAGTCAGGTAA

CCTTTGTCGGAGAAGTTGGCCCCTTTGTTGAGCAGATTCAAAAACACTTGCCAAGGACTGATTACAAAGAAACATT

GCCCAATGCAGCTAATCTAGCTCTTTTGGCCTGGGACAAGGAAGCAGACTCCTTGCATGATTTTGTGCCGAATTAC

CTCAAACGAGTCGAGGCTGAGGAAAACTGGCTCAAGAACCATACCGAGTCTGGCGAGTCTTACATTAAACGCCTA

TGA

4149.3

ATGATAGAAATCAAGCGAATTCAACAACAGCCTGACCTAGCTCAAGCCATCTACGCTGTTATGGCAGCTGTTTACC

TAGTCAGTCCTTGGACTCTGGAGCAAATCCAAGCAGATCTGTCCCAAGACCAGACTTGGTATGCATTGGCTTATGA

TGGGGCAGAAGTGATTGGATTTCTAGCTGTGCAGGAGAATCTTTTTGAAGCAGAAGTCCTGCAAATCGCTGTCAA

AGGAGCTTATCAGGGTCAGGGGATTGCGTCagCCTTGTTTGCTCAATTGCCGACAGACAAGGAAATTTTCCTCGAA

GTCAGACAGTCAAATCAACGAGCGCAAGCATTTTACAAGAAAGAAAAGATGACAGTTATCGCTGAGCGAAAGGC

CTACTACCATGACCCAGTCGAGGACGCCATTATCATGAAGAGAGAAATAGATGAAGGATAG

4152.2

ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAA

GGCTTTTCTACTCAATTGGTGACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCT

TGCTTGATATCATGTTACCACAATTAGATGGCATGGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTC

CAATTATGATGGTTTCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCT

GACCAAGCCTTTTAGCCCTAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGA

AGGAGATGATTCAGATAATATCGCTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAA

GTCTACAAGGCGAATAAGTTACTGAGTTTGACCCCAAAAGAATTTGAAAGCGATAAAAATCCGTTTTTTGAAGTTT

TCAAAGTTTCGAAAGTAACCGCCCAATAA

4154.1

ATGACTACTTTTAAAGATGGATTTTTATGGGGTGGTGCTGTTGCTGCTCATCAACTTGAAGGTGGATGGCAAGAAG

GTGGCAAGGGAATTAGTGTTGCTGATGTTATGACTGCTGGTCGTCATGGAGTAGCTCGTGAAATTACTTTGGGAGT

TTTAGAGGGTAAATATTATCCAAATCATGAGGCGATAGATTTTTATCACCGTTATAAAGAAGATATAGCACTTTTT

GCTGAAATGGGATTCAAGTGCTTCCGTACCTCTATTGCATGGACACGTATCTTTCCAAAAGGTGATGAGTTAGAGC

CGAATGAAGAAGGATTACAGTTTTATGATAATCTTTTTGATGAATGCTTAAAGAATGGTATTGAACCTGTCATCAC

TCTATCTCATTTTGAAATGCCTTATCACTTAGTGACCGAATATGGTGGTTGGAAAAATAGGAAATTGATTGATTTC

TTTGCTCGTTTTGCAGAAGTCGTATTTAAACGTTACAAAGATAAGGTTAAATATTGGATGACTTTCAATGAAATCA

ATAATCAAGCGAATTATCAGGAAGATTTTGCACCATTTACTAACTCAGGTATTGTATATGAGGAAGGTGATAATAG

AGAAGCAATTATGTATCAAGCAGCACATTACGAATTAGTTGCTTCTGCACGAGCTGTAAAAATTGGTCATGAGATT

AATCCAGATTTTCAAATAGGTTGTATGATTGCGATGTGTCCAATTTATCCAGTTACTTGCAATCCTAAGGATATCTT

AATGGCAATGAAAGCTATGCAGAAGCGTTATTATTTTGCTGATGTGCATGTTTTAGGTAAATATCCTGAGCATATT

TTCAAGTATTGGGAACGAAAAGGTATTTCAGTTGATTTTACTGCCCAGGATAAAGAAGATTTACTTGGTGGGACTG

TAGATTACATTGGTTTCAGTTACTATATGTCCTTTGCTATCGACTCTCATCGTGAAAATAATCCTTATTTTGATTAT

CTTGAAACAGAAGATTTAGTGAAAAATAATTATGTTAAGGCTTCTGAATGGGAGTGGCAAATTGATCCAGAAGGT

TTGCGTTATGCGTTAAATTGGTTTACAGACCACTATCACTTACCACTCTTTATTGTTGAAAATGGTTTTGGAGCTAT

AGATCAAGTTGCAGCAGATGGTATGGTACATGATGATTATAGAATTGAATATCTAGGTGCCCATATTCGTGAAATG

AAAAAGGCTGTAGTTGAAGATGGTGTTGATTTAATGGGTTATACTCCATGGGGATGTATTGATTTGGTTTCAGCTG

GTACCGGTGAAATGCGGAAACGTTATGGCTTTATTTATGTAGATAAAGATGATAATGGGAAGGGAAGTTATAATC

GTTCCCCGAAAAAATCTTTTGGCTGGTATAAGGAAGTTATTTCATCTAACGGTGAATCAGTAGAATAG

4154.2

ATGGATCAACAAAACGGGTTGTTTGGTTTTCTTGAAAACCATGTTATGGGACCAATGGGCAAACTTGCTCAGTTTA

AAGTAGTACGTGCTATCACGGCTGCAGGTATGGCTGCTGTACCATTTACTATTGTAGGATCAATGTTTTTGGTATT

CAGTATTTTGCCACAAGCTTTCTCATTTTGGCCAATTGTGGCAGATATTTTCTCTGCTTCATTTGATAAATTCACAT

CACTTTACATGGTTGCAAACTATGCGACTATGGGTTCTCTATCTCTTTATTTCGTTCTATCACTTGCATATGAATTG

ACAAAAATTTATGCAGAGGAAGAAGAACTCAATATGAATCCTCTTAATGGTGCCTTGCTTGCCTTGATGGCTTTTG

TCATGACAGTACCGCAAATCATTTTTGATGGTGGAATGATGAAGACTGTGACAAGTCTAAAAGAAGGTGCAGTAA

TTGCAGATGGATGGGCAATGGGAAATGTAGTCGCACGTTTTGGGACAACAGGGATTTTTACCGCAATCATTATGG

CAATTGTGACTGTTCTTATTTATCGTATGTGTGTTAAACATAATTGGGTTATTAAAATGCCTGAAGCTGTTCCAGAA

GGAGTTTCTCGTGGATTTACCGCTTTGGTTCCGGGATTTGTTGTTGCATTTGTTGTTATCTTTATCAACGGTCTTCTT

GTAGCAATGGGAACAGATATTTTTAAAGTCATTGCAATTCCATTTGGTTTTGTATCCAATCTGACTAATTCGTGGA

TTGGTTTAATGATTATTTATCTATTGACTCAACTACTTTGGATTGTAGGTATCCACGGTGCGAACATTGTTTTTGCA

TTTGTTAGTCCAATTGCTCTTGCTAACATGGCTGAAAATGCTGCTGGCGGGCACTTCGCTGTTGCAGGTGAATTTT

CTAATATGTTTGTAATTGCAGGTGGTTCTGGTGCAACTTTAGGACTATGTTTATATATTGCTTTTGCCTCTAAATCT

GAACAGCTTAAAGCAATAGGACGAGCATCTGTAGTTCCAGCCTTATTTAATATTAATGAACCATTAATTTTTGGAT

TACCTATTATCTATAATCCAGCCTTGGCTATACCATTTATTTTAGCACCAATGGTTACTGCTACTATTTATTACGTA

GCGAATTCTCTAAACTTTATTAAGCCAATTATCGCACAGGTTCCATGGCCAACTCCAGTAGGGATTGGAGCTTTCT

TAGGGACAGCAGATCTTCGAGCTGTATTAGTTGCTCTAGTATGTGCATTTGCAGCATTCCTAGTCTATCTTCCATTC

ATCCGTGTATATGATCAAAAATTGGTGAAAGAAGAGCAAGGTATCTAA

4155.1

ATGAAAAAATTTTATGTAAGTCCAATTTTTCCTATTCTAGTAGGATTGATTGCGTTTGGAGTCTTATCCACTTTCAT

TATTTTTGTTAATAATAATCTGTTGACGGTTTTAATTTTGTTTCTTTTTGTAGGAGGCTATGTTTTTTTATTTAAGAA

ACTGAGAGTGCATTATACAAGGAGTGATGTAGAACAGATACAGTATGTAAACCACCAAGCGGAAGAAAGTTTGAC

AGCTCTATTGGAACAGATGCCTGTAGGTGTTATGAAATTGAATTTATCTTCTGGAGAGGTTGAGTGGTTTAATCCC

TATGCTGAATTGATTTTGACCAAGGAAGATGGTGATTTTGATTTAGAAGCTGTTCAAACGATTATCAAGGCTTCAG

TAGGAAATCCGTCTACTTATGCCAAGCTTGGTGAGAAGCGTTATGCTGTTCATATGGATGCTTCTTCCGGTGTTTT

GTATTTTGTAGATGTATCCAGGGAACAAGCCATAACAGATGAATTGGTAACAAGTAGACCAGTGATTGGGATTGT

CTCTGTGGATAATTATGATGATTTGGAGGATGAAACTTCTGAGTCAGATATTAGTCAAATCAATAGTTTTGTAGCT

AATTTTATATCAGAGTTTTCAGAAAAACACATGATGTTTTCTCGTCGGGTAAGTATGGATCGATTTTATCTATTTAC

TGACTACACGGTGCTTGAGGGCTTGATGAATGATAAATTTTCTGTTATTGATGCTTTCAGAGAAGAGTCGAAACAG

AGACAGTTGCCCTTGACCTTAAGTATGGGATTTTCTTATGGCGATGGAAATCATGATGAGATAGGGAAAGTTGCTT

TGCTCAATTTGAACTTGGCTGAAGTACGTGGTGGCGACCAGGTGGTTGTTAAGGAAAACGACGAAACGAAAAATC

CAGTTTATTTTGGTGGTGGGTCTGCTGCTTCAATCAAGCGTACACGGACTCGTACGCGCGCTATGATGACAGCTAT

TTCAGATAAGATTCGGAGTGTAGATCAGGTTTTTGTAGTCGGTCACAAAAATTTAGACATGGATGCTTTGGGCTCT

GCTGTAGGTATGCAGTTGTTCGCCAGCAATGTGATTGAAAATAGCTATGCTCTTTATGATGAAGAACAAATGTCTC

CAGATATTGAACGAGCTGTTTCATTCATAGAAAAAGAAGGAGTTACGAAGTTGTTGTCTGTTAAGGATGCAATGG

GGATGGTGACCAATCGTTCTTTGTTGATTCTTGTAGACCATTCAAAGACAGCCTTAACATTATCAAAAGAATTTTA

TGATTTATTTACCCAAACCATTGTTATTGACCACCATAGAAGGGATCAGGATTTTCCAGATAATGCGGTTATTACT

TATATCGAAAGTGGTGCAAGTAGTGCCAGTGAGTTGGTAACGGAATTGATTCAGTTCCAGAATTCTAAGAAAAAT

CGTTTGAGTCGTATGCAAGCAAGTGTCTTGATGGCTGGTATGATGTTGGATACTAAAAATTTCACCTCGCGAGTAA

CTAGTCGGACATTTGATGTTGCTAGCTATCTCAGAACGCGCGGAAGTGATAGTATTGCTATCCAGGAAATCGCTGC

GACAGATTTTGAAGAATATCGTGAGGTCAATGAACTTATTTTACAGGGGCGTAAATTAGGTTCAGATGTACTAATA

GCAGAGGCTAAGGACATGAAATGCTATGATACAGTTGTTATTAGTAAGGCAGCAG?ATGCCATGTTAGCCATGTCA

GGTATTGAAGCGAGTTTTGTTCTTGCGAAGAATACACAAGG?ATTTATCTCTATCTCAGCTCGAAGTCGTAGTAAAC

TGAATGTACAACGGATTATGGAAGAGTTAGGCGGTGGAGGCCACTTTAATTTGGCAGCAGCTCAAATTAAAGATG

TAACCTTGTCAGAAGCAGGTGAAAAACTGACAGAAATTGTATTAAATGAAATGAAGGAAAAGGAGAAAGAAGAA

TGA

4156.1

ATGAAAGAGAAAAATATGTGGAAAGAATTGTTGAATCGTGCAGGCTGGATTTTGGTCTTTTTACTTGCCGTCCTTT

TATATCAGGTTCCCCTAGTGGTTACCTCTATTTTGACTTTAAAAGAAGTAGCCCTGCTACAGTCAGGGCTGATAGT

TGCTGGCCTTTCAATTGTGGTTCTGGCTCTATTTATTATGGGAGCTCGTAAAACCAAGTTAGCTAGTTTTAATTTTT

CTTTTTTTAGAGCTAAAGATTTGGCACGTTTGGGCTTGAGTTATCTAGTTATTGTCGGGTCAAATATACTTGGTTCC

ATTTTATTGCAACTGTCAAATGAGACGACAACAGCTAACCAGTCTCAGATTAATGATATGGTTCAAAATAGTTCGT

TGATTTCCAGTTTCTTCTTGCTAGCCTTGCTTGCTCCGATTTGTGAGGAAATCTTGTGTCGTGGGATTGTTCCTAAA

AAGATTTTCCGAGGCAAGGAGAACTTGGGATTTGTAGTCGGTACGATTGTGTTTGCTTTATTGCATCAACCAAGTA

ATTTACCTTCTTTATTGATTTATGGAGGTATGTCGACAGTTCTATCTTGGACAGCCTACAAGACCCAACGTTTGGA

AATGTCGATCTTGCTTCACATGATTGTTAATGGGATTGCTTTCTGTTTGTTGGCTCTTGTGGTGATTATGAGTCGGA

CATTAGGAATTTCTGTTTAAATGAAAGAGAAAAATATGTGGAAAGAATTGTTGAATCGTGCAGGCTGGATTTTGGT

CTTTTTACTTGCCGTCCTTTTATATCAGGTTCCCCTAGTGGTTACCTCTATTTTGACTTTAAAAGAAGTAGCCCTGC

TACAGTCAGGGCTGATAGTTGCTGGCCTTTCAATTGTGGTTCTGGCTCTATTTATTATGGGAGCTCGTAAAACCAA

GTTAGCTAGTTTTAATTTTTCTTTTTTTAGAGCTAAAGATTTGGCACGTTTGGGCTTGAGTTATCTAGTTATTGTCG

GGTCAAATATACTTGGTTCCATTTTATTGCAACTGTCAAATGAGACGACAACAGCTAACCAGTCTCAGATTAATGA

TATGGTTCAAAATAGTTCGTTGATTTCCAGTTTCTTCTTGCTAGCCTTGCTTGCTCCGATTTGTGAGGAAATCTTGT

GTCGTGGGATTGTTCCTAAAAAGATTTTCCGAGGCAAGGAGAACTTGGGATTTGTAGTCGGTACGATTGTGTTTGC

TTTATTGCATCAACCAAGTAATTTACCTTCTTTATTGATTTATGGAGGTATGTCGACAGTTCTATCTTGGACAGCCT

ACAAGACCCAACGTTTGGAAATGTCGATCTTGCTTCACATGATTGTTAATGGGATTGCTTTCTGTTTGTTGGCTCTT

GTGGTGATTATGAGTCGGACATTAGGAATTTCTGTTTAA

4156.4

ATGGATACACAAAAGATTGAAGCGGCTGTAAAAATGATTATCGAGGCTGTAGGAGAGGACGCTAATCGCGAGGGC

TTGCAGGAAACACCTGCTCGTGTAGCCCGTATGTATCAAGAGATTTTTTCAGGTCTTGGTCAAACAGCAGAGGAAC

ATTTGTCAAAATCCTTTGAAATTATTGACGATAATATGGTGGTAGAAAAGGATATCTTTTTCCATACCATGTGTGA

ACACCACTTCTTGCCATTTTATGGTAGAGCGCACATTGCCTACATTCCAGATGGTCGTGTGGCAGGCTTGTCTAAG

CTAGCCCGTACGGTTGAAGTTTATTCGAAAAAACCACAAATTCAAGAACGTTTGAATATCGAAGTGGCCGATGCC

TTGATGGACTATCTAGGTGCTAAAGGAGCCTTTGTTGTCATTGAGGCGGAACATATGTGTATGAGTATGCGTGGTG

TTAGAAAACCAGGCACTGCAACCTTGACGACAGTAGCTCGTGGTCTATTTGAAACAGATAAGGATCTCCGTGACC

AAGCTTATCGTTTAATGGGGCTATAA

4157.2

ATGAAAGACTTGTTTTTAAAGAGAAAGCAGGCCTTTCGTAAGGAGTGTCTTGGTTATCTGCGCTATGTGCTCAATG

ACCACTTTGTCTTGTTCCTGCTTGTCCTGTTGGGCTTTCTAGCCTACCAGTACAGTCAACTCTTACAACATTTTCCT

GAAAATCATTGGCCTATCCTTTTGTTTGTAGGAATTACGTCTGTTTTACTTTTACTTTGGGGAGGAACTGCCACCTA

TATGGAGGCTCCAGACAAGCTCTTTCTCTTAGTTGGAGAAGAGGAAATTAAGCTCCATCTCAAGCGTCAAACTGG

CATTTCCCTAGTCTTTTGGCTCTTTGTACAGACCCTTTTCTTGCTGTTATTTGCGCCTTTATTTTTAGCAATGGGTTA

TGGCTTGCCAGTTTTTCTGCTCTATGTGCTTTTATTGGGGGTAGGAAAATATTTCCACTTTTGTCAAAAGGCCAGCA

AATTTTTCACTGAAACTGGACTGGACTGGGACTATGTTATTTCTCAAGAAAGCAAGCGTAAGCAAGTCTTGCTTCG

TTTCTTTGCCCTCTTTACGCAGGTCAAGGGAATTTCAAACAGCGTTAAGCGTCGTGCCTATCTGGACTTTATTTTAA

AGGCTGTTCAGAAGGTGCCTGGGAAGATTTGGCAAAATCTCTATCTGCGTTCTTATCTGCGAAATGGCGACCTCTT

TGCTCTCAGTCTTCGTCTTCTCTTGCTTTCCTTGCTGGCGCAGGTTTTTATCGAGCAAGCTTGGATTGCGACAGCAG

TGGTAGTTCTCTTTAACTACCTCTTGCTCTTCCAGTTGCTGGCCCTCTATCATGCCTTTGACTACCAGTATTTGACC

CAACTCTTTCCGCTGGACAAGGGGCAAAAGGAAAAAGGCTTACAGGAGGTAGTTCGAGGATTGACCAGTTTTGTT

TTACTTGTGGAATTAGTTGTTGGGTTGATTACCTTCCAAGAAAAACTAGCCCTTCTAGCCTTACTAGGAGCTGGTT

TGGTTTTACTAGTCTTGTATTTGCCTTATCAGGTAAAACGTCAGATGCAGGACTAA

4158.1

ATGAGAAAATCAATAGTATTAGCGGCAGATAATGCCTATCTTATTCCTTTAGAGACGACTATAAAGTCTGTATTGT

ATCACAATAGAGATGTTGATTTTTATATTCTCAACAGTGATATAGCTCCTGAATGGTTTAAATTATTGGGGAGAAA

AATGGAAGTTGTGAATTCTACAATTCGCAGTGTACACATTGATAAAGAACTTTTTGAAAGCTATAAAACAGGACCT

CATATAAATTATGCTTCTTACTTTAGATTTTTTGCGACAGAAGTGGTTGAATCTGATAGGGTATTGTATCTGGATTC

CGATATCATTGTAACTGGGGAACTAGCTACTTTGTTTGAGATAGATCTCAAAGGATATTCAATTGGTGCTGTTGAT

GATGTCTATGCCTATGAAGGACGAAAATCTGGATTTAATACTGGTATGTTACTAATGGATGTTGCAAAGTGGAAAG

AACATTCTATTGTCAATAGTTTATTGGAATTAGCGGCCGAGCAGAATCAAGTTGTTCATCTTGGGGATCAGAGTAT

TTTAAATATTTATTTTGAGGATAATTGGCTAGCCTTAGATAAAACATATAATTATATGGTGGGTATTGATATTTATC

ACCTTGCTCAAGAATGTGAACGTCTAGATGACAATCCACCTACAATTGTTCACTATGCTAGTCATGATAAACCTTG

GAATACATATAGTATATCTAGACTACGTGAATTATGGTGGGTTTATAGAGATTTGGATTGGTCAGAGATTGCTTTT

CAACGTTCCGATTTAAATTATTTTGAAAGAAGCAATCAGTCTAAAAAACAAGTGATGCTTGTGACATGGAGTGCA

GATATAAAACATTTAGAGTATTTAGTACAACGGTTACCTGATTGGCATTTTCATTTGGCTGCACCGTGTGATTGTTC

TGAGGAGCTGACCTCTCTATCACAGTATACGAATGTAACAGTATATCAAAATGTATTACATAGTAGAATTGATTGG

CTATTGGACGATTCTATAGTTTATTTAGATATTAATACAGGTGGAGAGGTTTTTAATGTAGTTACAAGGGCACAAG

AAAGTGGCAAGAAAATCTTCGCTTTTGATATCACACGTAAAAGTATGGATGATGGACTCTATGACGGTATTTTTTC

TGTGGAGAGACCAGATGATTTAGTGGATAGAATGAAGAATATAGAGATAGAGTAA

4158.2

ATGACTAAGATTTATTCGTCAATAGCAGTAAAAAAAGGACTATTTACCTCATTTCTACTGTTTATCTATGTATTGG

GAAGTCGTATTATTCTCCCTTTTGTTGACCTAAATACTAAAGATTTTTTAGGAGGTTCAACAGCCTATCTAGCCTTC

TCAGCCGCCCTAACAGGTGGGAATCTAAGAAGTTTATCAATTTTTTCTGTTGGATTATCCCCTTGGATGTCCG?CCA

TGATTTTATGGCAGATGTTTTCTTTTTCTAAACGGTTGGGTTTAACATCTACGTCTATAGAAATACAAGATCGCCGT

AAAATGTACCTGACCTTGCTAATTGCTGTGATTCAATCCTTGGCAGTTAGCTTGAGACTGCCAGTACAATCCTCCT

ATTCTGCAATATTGGTTGTTCTAATGAATACAATATTGCTGATAGCAGGAACATTTTTTCTTGTTTGGTTGTCAGAT

TTAAATGCGAGTATGGGGATTGGAGGTTCTATTGTAATCCTCCTATCCAGTATGGTTTTAAATATTCCTCAGGATG

TTTTGGAAACATTTCAGACAGTACACATTCCAACAGGGATTATTGTGTTACTTGCTTTATTAACCCTTGTCTTTTCT

TATTTACTTGCCCTTATGTATCGAGCTCGCTATTTGGTTCCTGTTAATAAAATTGGCTTACACAATCGATTTAAACG

CTATTCTTATCTCGAAATCATGTTGAATCCTGCAGGTGGGATGCCTTATATGTATGTGATGAGTTTTCTTAGTGTAC

CAGCTTATTTGTTCATCTTGTTGGGATTTATTTTCCCTAATCATTCAGGGTTAGCGGCTTTATCAAAGGAATTTATG

GTTGGAAAGCCTTTGTGGGTCTATGTTTATATTTCGGTCTTATTTTTATTTAGTATCATTTTTGCTTTTGTTACGATG

AATGGAGAAGAGATTGCAGACCGTATGAAAAAATCTGGAGAATACATTTATGGTATTTATCCAGGTGCGGATACT

AGTCGATTTATTAATCGATTGGTCCTTCGTTTCTCAGTCATAGGTGGTCTCTTTAATGTGATTATGGCAGGTGGTCC

CATGCTTTTTGTTTTGTTTGATGAAAAGTTATTACGATTGGCAATGATTCCAGGCTTATTTATGATGTTCGGGGGCA

TGATTTTTACGATTAGAGACGAGGTCAAGGCTTTAAGGCTAAATGAGACCTATAGACCTTTGATTTAG

4158.3

ATGTCCTCTCTTTCGGATCAAGAATTAGTAGCTAAAACAGTAGAGTTTCGTCAGCGTCTTTCCGAGGGAGAAAGTC

TAGACGATATTTTGGTTGAAGCTTTTGCTGTGGTGCGTGAAGCAGATAAGCGGATTTTAGGGATGTTTCCTTATGA

TGTTCAAGTCATGGGAGCTATTGTCATGCACTATGGAAATGTTGCTGAGATGAATACGGGGGAAGGTAAGACCTT

GACAGCTACCATGCCTGTCTATTTGAACGCTTTTTCAGGAGAAGGAGTGATGGTTGTGACTCCTAATGAGTATTTA

TCAAAGCGTGATGCCGAGGAAATGGGTCAAGTTTATCGTTTTCTAGG?ATTGACCATTGGTGTACCATTTACGGAAG

ATCCAAAGAAGGAGATGAAAGCTGAAGAAAAGAAGCTTATCTATGCTTCGGATATCATCTACACAACCAATAGTA

ATTTAGGTTTTGATTATCTAAATGATAACCTAGCCTCGAATGAAGAAGGTAAGTTTTTACGACCGTTTAACTATGT

GATTATTGATGAAATTGATGATATCTTGCTTGATAGTGCACAAACTCCTCTGATTATTGCGGGTTCTCCTCGTGTTC

AGTCTAATTACTATGCGATCATTGATACACTTGTAACAACCTTGGTCGAAGGAGAGGATTATATCTTTAAAGAGGA

GAAAGAGGAGGTTTGGCTCACTACTAAGGGGGCCAAGTCTGCTGAGAATTTCCTAGGGATTGATAATTTATACAA

GGAAGAGCATGCGTCTTTTGCTCGTCATTTGGTTTATGCGATTCGAGCTCATAAGCTCTTTACTAAAGATAAGGAC

TATATCATTCGTGGAAATGAGATGGTACTGGTTGATAAGGGAACAGGGCGTCTAATGGAAATGACTAAACTTCAA

GGAGGTCTCCATCAGGCTATTGAAGCCAAGGAACATGTCAAATTATCTCCTGAGACGCGGGCTATGGCCTCGATC

ACCTATCAGAGTCTTTTTAAGATGTTTAATAAGATATCTGGTATGACAGGGACAGGTAAGGTCGCGGAAAAAGAG

TTTATTGAAACTTACAATATGTCTGTAGTACGCATTCCAACCAATCGTCCGAGACAACGGA

TTGACTATCCAGATAATCTATATATCACTTTACCTGAAAAAGTGTATGCATCCTTGGAGTACATCAAGCAATACCA

TGCTAAGGGAAATCCTTTACTCGTTTTTGTAGGCTCAGTTGAAATGTCTCAACTCTATTCGTCTCTCTTGTTTCGTG

AAGGGATTGCCCATAATGTCCTAAATGCTAATAATGCGGCGCGTGAGGCTCAGATTATCTCCGAGTCAGGTCAGA

TGGGGGCTGTGACAGTGGCTACCTCTATGGCAGGACGTGGTACGGATATCAAGCTTGGTAAAGGAGTCGCAGAGC

TTGGGGGCTTGATTGTTATTGGGACTGAGCGGATGGAAAGTCAGCGGATCGACCTACAAATTCGTGGCCGTTCTGG

TCGTCAGGGAGATCCTGGTATGAGTAAATTTTTTGTATCCTTAGAGGATGATGTTATCAAGAAATTTGGTCCATCT

TGGGTGCATAAAAAGTACAAAGACTATCAGGTTCAAGATATGACTCAACCGGAAGTATTGAAAGGTCGTAAATAC

CGGAAACTAGTCGAAAAGGCTCAGCATGCCAGTGATAGTGCTGGACGTTCAGCACGTCGTCAGACTCTGGAGTAT

GCTGAAAGTATGAATATACAACGGGATATAGTCTATAAAGAGAGAAATCGTCTAATAGATGGTTCTCGTGACTTA

GAGGATGTTGTTGTGGATATCATTGAGAGATATACAGAAGAGGTAGCGGCTGATCACTATGCTAGTCGTGAATTAT

TGTTTCACTTTATTGTGACCAATATTAGTTTTCATGTTAAAGAGGTTCCAGATTATATAGATGTAACTGACAAAACT

GCAGTTCGTAGCTTTATGAAGCAGGTGATTGATAAAGAACTTTCTGAAAAGAAAGAATTACTTAATCAACATGACT

TATATGAACAGTTTTTACGACTTTCACTGCTTAAAGCCATTGATGACAACTGGGTAGAGCAGGTAGACTATCTACA

ACAGCTATCCATGGCTATCGGTGGTCAATCTGCTAGTCAGAAAAATCCAATCGTAGAGTACTATCAAGAAGCCTA

CGCGGGCTTTGAAGCTATGAAAGAACAGATTCATGCGGATATGGTGCGTAATCTCCTGATGGGGCTGGTTGAGGT

CACTCCAAAAGGTGAAATCGTGACTCATTTTCCATAA

4158.4

ATGATAGGGACTTTCGCCGCTGCTCTTGTAGCTGTACTAGCAAATTTCATCGTCCCTATTGAAATTACCCCAAATA

GTGCCAATACTGAAATTGCACCACCAGATGGGATTGGGCAGGTTCTCAGCAACCTCTTGCTCAAACTGGTTGACA

ACCCAGTCAACGCCCTGCTTACTGCTAACTATATTAGAATCTTATCTTGGGCAGTCATTTTTGGAATCGCTATGAG

AGAAGCCAGTAAAAATAGTCAAGAATTGCTAAAAACTATCGCTGACGTGACTTCTAAAATTGTCGAATGGATCAT

CAATCTGGCTCCATTTGGAATCCTTGGTCTTGTTTTTAAAACCATTTCTGACAAGGGAGTCGGAAGCCTTGCCAAC

TACGGTATTTTATTGGTTCTATTAGTAACGACTATGCTTTTTGTTGCCCCTGTGGTCAACCCTTTGATTGCCTTCTTC

TTTATGAGACGCAATCCTTACCCTCTAGTTTGGAACTGCCTCCGTGTCAGCGGTGTGACAGCCTTTTTCACTCGTA

GTTCTGCGACTAACATTCCTGTCAACATGAAACTCTGCCATGACCTTGGACTCAACCCAGATACCTATTCTGTTTC

TATCCCACTCGGTTCTACTATCAATATGGCTGGAGTAGCGATTACCATTAACCTTTTGACCCTTGCTGCAGTTAAC

ACTCTTGGAATTCCTGTTGACTTTGCCACAGCCTTTGTCCTCAGTGTGGTAGCAGCTATCTCATCCTGTGATGCTTC

AGGTATTGCCGGAGGTTCCCTCCTTCTTATCCCAGTTGCTTGTAGCCTTTTCGGTATTTCTAACGATATTGCCATAC

AAATTGTTGGGGTTGGTTTTGTGATTGGTGTCATCCAAGACTCATGTGAAACAGCCCTTAACTCTTCTACAGATGT

CCTCTTTACCGCCGTTGCCGAATACGCAGCAACCCGTAAAAAATAA

4158.5

ATGTCTATTAGCCAACGTACGACCAAGCTCATCTTAGCTACCTGTCTTGCCTGCCTGCTTGCTTATTTTCTCAATCT

TTCGTCAGCAGTTTCGGCTGGAATTATCGCTCTCTTGAGCCTATCTGATACGCGTAGAAGTACTTTAAAACTGGCT

CGCAATCGTCTTTTTTCTATGCTTCTAGCTCTGGCTATCGGTGTTCTAGCTTTTCACTTGAGCGGATTTCATATCTG

GAGTCTCGGCCTCTATCTGGCCTTCTACGTTCCTTTAGCCTACAAGATGGGCTGGGAAATTGGCATCACACCAAGC

ACTGTTTTGGTTAGCCATCTCTTGGTTCAAGAGTCAACCTCTCCAGACCTTCTAGTCAATGAATTCCTTCTCTTTGC

TATTGGTACAGGATTTGCCTTGCTTGTTAATCTCTATATGCCTTCACGAGAAGAGGAAATCCAGCACTACCACACG

CTGGTGGAAGAAAAGTTAAAAGATATCCTCCAGCGCTTCAAATACTATTTATCCAGAGGAGACGGACGCAACCGA

GCACAGCTGGTAGCAGAATTAGACACGCTTTTGAAAGAAGCCCTCAGACTGGTCTATTTGGATCACTCTGACCACC

TCTTTCACCAGACAGACTACCATATCCACTACTTTGAGATGAGACAGCGACAAAGTCGTATCCTGAGAAACATGG

CCCAACAGATTAACACTTGTCACCTTGCCGCCAGTGAAAGCCTGATCTTAGCGCAACTCTTTTCAAAAATTGCAGG

TCAACTGAGCCAGACCAATCCTGCTTCTGATTTGCTAGATGAAATTGAACGTTATCTGGAAGTCTTCCGGAACCGC

AGTCTGCCCAAGACAAGAGAAGAATTTGAAACCCGCGCCACCCTTCTTCAACTCCTACGTGAAGCCAAAACCTTC

ATCCAAGTAAAAGTTGATTTTTACCAAAAATATAGACAGTAA

4158.6

ATGGAAATCATGTCGCTTGCGATTGCTGTTTTTGCCGTCATCATTGGTTTAGTCATTGGATATGTCAGCATCTCAGC

TAAGATGAAATCATCTCAGGAAGCTGCAGAGTTGATGCTTTTAAATGCTGAACAAGAAGCAACTAATTTACGTGG

ACAAGCTGAGCGTGAAGCGGATTTACTTGTTAATGAAGCCAAACGTGAAAGCAAGTCTCTTAAAAAAGAAGCACT

ATTGGAGGCCAAAGAAGAAGCCAGAAAATACCGTGAAGAAGTGGACGCTGAATTCAAATCAGAACGTCAAGAAC

TCAAACAAATCGAAAGTCGTTTGACAGAGAGAGCTACTAGCCTTGACCGTAAGGACGACAATTTGACGAGTAAAG

AACAAACACTTGAACAAAAAGAACAAAGTATTTCTGATAGAGCGAAAAACCTTGATGCGCGTGAAGAGCAATTAG

AGGAAGTCGAAAGACAAAAAGAAGCAGAACTAGAGCGTATTGGTGCGCTGTCTCAGGCAGAAGCACGAGATATT

ATCTTGGCTCAGACAGAGGAAAACTTGACCAGGGAGATTGCCAGTCGCATTCGCGAAGCTGAGCAAGAGGTCAAG

GAACGTTCTGACAAAATGGCCAAGGACATCTTGGTTCAAGCTATGCAACGTATCGCTGGTGAATATGTAGCGGAG

TCAACAAACTCAACAGTTCATCTGCCAGACGATACTATGAAGGGACGCATTATTGGTCGTGAAGGTCGTAACATT

CGTACCTTTGAAAGTTTGACAGGGGTCGATGTGATTATCGACGATACACCAGAAGTGGTGACCTTGTCAGGATTTG

ATCCGATTCGTCGTGAGATTGCCCGTATGACTATGGAAATGTTGCTCAAAGATGGTCGTATACATCCAGCTCGTAT

CGAAGAGTTGGTTGAGAAAAACCGTCAAGAGATTGACAATAAGATTCGTGAATACGGTGAGGCTGCTGCCTATGA

AATTGGTGCGCCAAACCTTCATCCAGACTTGATGAAGATTATGGGACGTTTGCAGTTCCGTACTTCATATGGACAA

AATGTTTTGCGCCATTCGATTGAGGTTGCTAAGTTGGCTGGTATCATGGCGAGCGAACTTGGTGAAAATGCGGCTC

TTGCCCGTCGTGCTGGATTCCTTCACGATATCGGGAAAGCCATTGACCATGAGGTTGAAGGTAGCCACGTTGAAAT

CGGTATGGAATTGGCCCGTAAGTACAAGGAACCCCCAGTTGTGGTGAATACGATTGCTAGTCACCACGGAGATGT

TGAAGCTGAGAGCGTGATAGCAGTTATCGTCGCTGCAGCAGATGCCTTGAGCGCAGCCCGTCCAGGTGCTCGTAG

TGAGTCTCTTGAAAGCTACATCAAGCGTCTCCATGATTTGGAAGAAATTGCTAACGGCTTTGAAGGAGTGCAAACT

AGCTTTGCCCTTCAAGCAGGACGTGAAATTCGTATCATGGTCAATCCAGGAAAAATCAAGGACGACAAAGTCACA

ATCTTGGCTCACAAAGTTCGTAAGAAAATTGAAAACAATCTCGATTATCCAGGAAATATCAAGGTAACCGTGATT

CGCGAGCTTCGTGCAGTAGATTATGCTAAATAA

4158.7

ATGATGTTAAAACCCTCTATTGATACCTTGCTCGACAAGGTTCCTTCAAAATATTCACTCGTAATCTTGGAAGCAA

AACGTGCCCACGAATTGGAAGCAGGTGCCCCAGCAACTCAAGGTTTCAAGTCTGAAAAATCAACTCTTCGCGCTT

TAGAAGAAATCGAATCAGGAAACGTTACAATTCACCCAGATCCAG?AAGGAAAACGTGAAGCAGTGCGTCGCCGTA

TCGAAGAAGAAAAACGCCGCAAAGAAGAAGAAGAAAAGAAAATCAAAGAGCAAATTGCTAAAGAAAAAGAAGA

TGGTGAAAAAATTTAA

4161.1

ATGTCAGCATATCAATTACCGACCGTATGGCAGGATGAAGCTAGTAATCAAGGAGCTTTTACGGGGCTAAACAGA

CCAACAGCAGGTGCCCGTTTCGAACAAAACTTGCCAAAAGGAGAACAAGCTTTTCAGCTTTATTCACTGGGAACA

CCAAATGGTGTGAAGGTTACTATCTTATTGGAAGAATTACTAGAAGCTGGTTTTAAGGAAGCGGCTTACGACTTGT

ATAAGATTGCTATCATGGATGGGGATCAATTCGGATCAGACTTTGTGAAGCTCAATCCAAATTCCAAGATTCCAGC

CTTATTGGACCAGTCAGGTACTGAAAACGTAAGAGTCTTTGAGTCTGCTCATATTCTTCTTTACCTTGCTGAGAAA

TTTGGAGCCTTTTTACCAAGTAATCCTGTGGAAAAGGTAGAAGTTTTGAATTGGCTATTCTGGCAAGCAGGTGCAG

CACCTTTTCTAGGTGGGGGATTTGGACATTTCTTCAATTATGCTCCTGAAAAATTGGAATATCCTATTAACCGTTTT

ACGATGGAAGTGAAACGCCAGTTGGATTTATTGGATAAGGAATTGGCTCAGAAACCTTATATTGCAGGCAATGAC

TATACGATTGCAGATATTGCTATCTGGTCTTGGTATGGACAGTTAGTTCAAGGAAATCTTTACCAAGGTTCTGCAA

AATTCTTGGATGCCTCAAGTTATCAAAATCTAGTAAAATGGGCAGAAAAAATTGCCAATCGTCCAGCTGTTAAGC

GTGGCTTGGAAGTAACTTATACAGAAATTAAATAG

4161.2

TTGGCAAGCTTGATCACTTCTATCATCATGTTCTATGTCGGTTTCGATGTTCTAAGAGATACCATTCAAAAGATTCT

CAGTCGGGAAGAAACGGTCATTGATCCTCTTGGTGCAACTCTAGGAATCATTTCTGCAGCGATTATGTTTGTGGTC

TATCTCTACAATACTCGCCTCAGTAAGAAATCCAACTCCAATGCGCTGAAGGCAGCTGCTAAGGACAATCTTTCTG

ACGCTGTTACCTCACTTGGAACCGCCATTGCCATCCTAGCTAGTAGTTTCAATTATCCGATTGTGGATAAACTGGT

TGCTATCATCATCACTTTCTTTATCTTGAAGACTGCCTATGATATCTTCATCGAGTCTTCCTTTAGTCTTTCAGATG

GCTTTGACGACCGCCTGCTCGAGGACTACCAAAAGGCTATCATGGAAATTCCCAAAATCAGCAAGGTCAAATCGC

AAAGAGGTCGCACCTACGGTAGCAACATCTACCTGGATATTACACTAGAGATGAATCCTGACTTGTCTGTTTTTGA

AAGCCATGAAATCGCGGATCAGGTCGAGTCTATGCTGGAGGAGCGTTTTGGCGTCTTTGATACCGATGTCCATATC

GAACCAGCACCTATCCCTGAGGATGAAATTTTAGACAATGTCTATAAAAAATTGCTTATGCGTGAACAATTGATTG

ACCAAGG?AAACCAACTAGAAGAACTCTTGACTGATGATTTTGTCTATATTCGCCAAGATGGAGAGCAGATGGATA

AAGAGGCTTATAAGACCAAAAAAGAGTTAAATTCTGCTATCAAGGACATTCAAATTACTTCCATCAGTCAAAAAA

CCAAACTCATCTGCTATGAGTTAGATGGTATCATCCATACCAGTATCTGGCGTCG?CCACGAAACCTGGCAAAATAT

CTTTCATCAAGAAACCAAAAAAGAATAG

4162.1

ATGACAATTAAACTAGTAGCAACGGATATGGACGGAACCTTCCTAGATGGGAATGGACGCTTTGATATGGATCGT

CTCAAGTCTCTCTTGGTTTCCTACAAGGAAAAAGGGATTTACTTTGCGGTAGCTTCGGGTCGGGGATTTCTGTCTC

TAGAAAAATTATTTGCTGGTGTTCGTGATGACATTATTTTCATCGCGGAAAATGGCAGTTTGGTAGAGTATCAAGG

TCAGGACTTGTATGAAGCGACTATGTCTCGTGACTTTTATCTGGCAACTTTTGAAAAGCTGAAAACTTCACCTTAT

GTAGATATCAATAAACTGCTCTTGACGGGTAAGAAGGGTTCATATGTTCTAGATACGGTTGATGAGACCTATTTGA

AAGTGAGTCAGCACTATAATGAAAATATCCAAAAAGTAGCGAGTTTGGAAGATATCACAGATGACATTTTCAAAT

TTACAACCAACTTCACAGAAGAAACGCTGGAAGATGGGGAGGCTTGGGTAAACGAAAACGTTCCTGGTGTTAAGG

CCATGACAACTGGCTTTGAATCCATTGATATTGTTCTGGACTATGTCGATAAGGGAGTGGCCATTGTTGAATTAGT

TAAAAAACTTGGTATCACAATGGATCAGGTCATGGCTTTTGGAGACAATCTTAATGACTTACATATGATGCAGGTT

GTGGGACATCCTGTAGCTCCTGAAAATGCACGACCTGAAATTTTAGAATTAGCAAAGACTGTGATTGGTCACCATA

AGGAACGGTCGGTTATAGCTTATATGGAGGGCTTATAA

4162.2

ATGGCAGATATAAAATTGATTGCATTGGACTTGGACGGGACCTTGCTGACTACTGATAAAAGGCTGACGGATCGT

ACCAAGGAAACCTTGCAAGCTGCGCGTGATCGTGGTATCAAGGTCGTATTGACAACTGGTCGTCCCTTAAAAGCC

ATGGATTTCTTTCTCCATGAGTTAGGGACTGACGGTCAGGAAGATGAGTATACCATTACTTTTAATGGTGGATTAG

TTCAGAAAAATACAGGAGAAATCCTTGATAAAACAGTCTTTTCATATGATGATGTGGCACGTTTGTATGAAGAAAC

AGAGAAATTATCACTGCCTCTTGATGCCATCTCAGAAGGAACAGTTTATCAAATCCAATCGGACCAAGAAAGTCT

TTATGCCAAATTCAATCCAGCTTTGACCTTTGTTCCAGTGGACTTTGAAGACTTATCTAGTCAAATGACCTACAAC

AAATGCGTGACTGCCTTTGCTCAAGAACCCTTGGATGCAGCCATTCAGAAGATTTCTCCAGAATTGTTTGACCAAT

ATGAAATCTTTAAATCACGTGAAATGTTGCTAGAATGGTCACCAAAGAATGTTCATAAAGCAACAGGTTTGGCAA

AACTAATCAGCCATCTTGGAATCGACCAAAGTCAAGTGATGGCTTGTGGTGACGAGGCCAATGACCTCTCTATGA

TTGAATGGGCAGGTCTTGGTGTTGCTATGCAAAACGCTGTTCCTGAAGTAAAGGCAGCCGCAAATGTAGTGACGC

CGATGACCAACGATGAGGAAGCTGTCGCCTGGGCTATCGAAGAATATGTGCTAAAGGAGAACTAA

4164.2

ATGGAAAGTTTACTTATTCTATTATTAATTGCCAATCTAGCTGGTCTCTTTCTGATTTGGCAAAGGCAGGATAGGC

AGGAGAAACACTTAAGTAAGAGCTTGGAGGATCAGGCAGATCATTTGTCAGACCAGTTGGATTACCGCTTTGACC

AAGCCAGACAAGCCAGCCAGTTAGACCAAAAAGATTTGGAAGTGGTTGTCAGCGACCGTTTGCAAGAAGTGCGGA

TTGAATTGCACCAAGGTCTGACCCAAGTCCGTCAAGAAATGACAGATAATCTCCTCCAAACTAGAGACAAGACAG

ACCAACGTCTCCAAGCCTTGCAGGAATCAAATGAGCAACGTTTGGAACAAATGCGCCAGACGGTCGAGGAAAAAC

TAGAAAAGACCTTGCAGACACGCTTACAGGCTTCCTTTGAGACAGTTTCTAAACAACTGGAGTCTGTCAATCGTGG

CCTTGGAGAAATGCAGACAGTTGCCCGTGATGTCGGAGCTCTTAACAAGGTTCTCTCTGGAACCAAGACGCGAGG

GATTCTGGGAGAATTGCAACTGGGGCAAATTATTGAAGACATCATGACACCTGCCCAGTACGAACGAGAATACGC

AACGGTTGAAAACTCTAGTGAACGAGTGGAGTATGCCATCAAGTTACCCGGACAAGGCGACCAAGAATACGTCTA

TCTGCCAATTGACTCTAAGTTTCCACTGGCAGATTATTACCGCTTGGAAGAAGCCTATGAGACAGGTGACAAGGAT

GAGATTGAACGCTGTCGTAAGTCACTCCTAGCAAGCGTCAAGCGCTTTGCTAGGGATATTAGGAACAAGTACATA

GCACCACCTCGGACGACCAATTTTGGAGTTTTGTTTGTTCCGACAGAAGGTCTCTACTCAGAAATCGTCCGCAATC

CGGTCTTCTTTGATGATTTGAGACGGGAAGAACAGATTATTGTTGCAGGACCAAGTACCCTATCAGCCCTTCTTAA

CTCCCTATCAGTTGGTTTCAAGACCCTTAATATCCAAAAGAGTGCCGACCATATCAGCAAGACTCTTGCCAGTGTC

AAGACCGAGTTTGGCAAGTTTGGTGGTATTCTGGTCAAGGCACAAAAACATCTCCAACATGCCTCTGGCAATATTG

ATGAATTATTAAACCGTCGTACCATAGCTATCGAGCGGACGCTCCGTCACATTGAGTTGTCAGAAGGTGAGCCTGC

GCTTGATCTACTCCATTTTCAAGAAAATGAGGAAGAATATGAAGATTAG

4164.3

ATGAAGATTAGTCACATGAAAAAAGATGAGTTATTTGAAGGCTTTTACCTAATCAAATCAGCTGACCTGAGGCAA

ACTCGAGCTGGGAAAAACTACCTAGCCTTTACCTTCCAAGATGATAGTGGCGAGATTGATGGGAAGCTCTGGGAT

GCCCAACCTCATAACATTGAGGCCTTTACCGCAGGTAAGGTTGTCCACATGAAAGGACGCCGAGAAGTTTATAAC

AATACCCCTCAAGTCAATCAAATTACTCTCCGCCTGCCTCAAGCTGGTGAACCCAATGACCCAGCTGATTTCAAGG

TCAAGTCACCAGTTGATGTCAAGGAAATTCGTGACTACATGTCGCAAATGATTTTCAAAATTGAAAATCCTGTCTG

GCAACGGATTGTCCGAAATCTCTACACCAAGTATGATAAGGAATTCTACTCCTATCCAGCTGCCAAGACCAACCA

CCATGCCTTTGAAACGGGCTTGGCCTATCATACGGCGACCATGGTGCGTTTGGCAGACGCTATTAGCGAAGTTTAT

CCTCAGCTCAATAAGAGCCTGCTCTATGCGGGGATTATGTTGCATGACTTAGCTAAGGTCATCGAGTTGACGGGGC

CAGACCAGACAGAGTACACAGTGCGAGGTAATCTTCTTGGACATATCGCTCTCATTGATAGCGAAATTACCAAGA

CAGTTATGGAACTCGGCATCGATGATACCAAGGAAGAAGTCGTTTTGCTTCGTCATGTCATCCTCAGTCACCACGG

CTTGCTTGAGTATGGAAGCCCAGTCCGTCCACGCATTATGGAAGCAGAGATTATCCATATGATTGACAATCTGGAT

GCAAGCATGATGATGATGTCAACAGCTCTTGCTTTGGTGGATAAAGGAGAGATGACCAATAAAATCTTCGCTATG

GATAATCGTTCCTTCTATAAACCAGATTTAGATTAA

4166.2

ATGAGTGAAAAAGCTAAAAAAGGGTTTAAGATGCCTTCATCTTACACCGTATTATTGATAATCATTGCTATTATGG

CAGTGCTAACTTGGTTTATCCCTGCGGGGGCCTTTATAGAAGGTATTTACGAGACTCAGCCTCAAAATCCACAAGG

GATTTGGGATGTCCTCATGGCACCGATTCGGGCTATGCTAGGTACTCATCCAGAGGAAGGTTCGCTCATTAAAGAA

ACGAGCGCAGCGATTGATGTAGCCTTCTTCATCCTTATGGTTGGTGGTTTCCTTGGCATTGTCAACAAAACTGGTG

CTCTTGACGTAGGGATTGCCTCTATCGTGAAGAAGTATAAGGGCCGCGAAAAAATGTTAATTTTGGTACTGATGCC

TTTGTTTGCCCTCGGTGGTACAACTTATGGTATGGGTGAAGAAACAATGGCCTTCTATCCACTCCTTGTGCCAGTT

ATGATGGCCGTTGGTTTTGATAGCCTGACTGGTGTTGCAATTATTTTGCTCGGTTCTCAAATCGGCTGTTTGGCATC

TACTCTGAATCCATTTGCGACAGGTATTGCTTCAGCGACTGCGGGAGTTGGTACAGGGGACGGTATCGTACTTCGT

CTGATCTTCTGGGTTACCTTGACTGCTCTTAGTACTTGGTTTGTTTACCGTTATGCGGATAAGATTCAAAAAGATCC

GACTAAGTCACTGGTTTATAGTACTCGCAAAGAAGATTTGAAACACTTTAACGTAGAAGAATCTTCATCTGTAGAA

TCTACACTTAGCAGCAAACAAAAATCAGTTCTCTTCTTATTTGTGTTGACATTCATCTTGATGGTATTGAGCTTCAT

TCCATGGACAGACCTTGGCGTTACCATTTTTGATGACTTTAATACTTGGTTGACTGGTCTTCCAGTTATTGGTAATA

TTGTCGGTTCATCTACTTCTGCACTAGGTACTTGGTACTTCCCAGAAGGCGCAATGCTCTTTGCCTTTATGGGTATC

CTGATTGGTGTTATTTATGGTCTTAAAGAAGATAAGATTATCTCTTCCTTCATGAATGGTGCTGCTGACTTGCTCAG

TGTTGCCTTGATCGTAGCGATTGCTCGTGGTATTCAAGTTATCATGAACGACGGTATGATTACCGATACAATCCTC

AACTGGGGTAAAGAAGGCTTGAGCGGTCTATCTTCACAAGTCTTTATCGTTGTAACTTATATCTTCTATCTACCTAT

GTCATTCTTGATCCCATCTTCATCTGGTCTTGCCAGCGCAACTATGGGTATCATGGC

TCCACTTGGAGAATTTGTAAATGTCCGTCCTAGCTTGATTATCACTGCTTACCAATCTGCTTCAGGTGTCTTGAACT

TGATTGCACCAACATCTGGTATTGTGATGGGAGCTCTTGCACTTGGACGTATCAACATTGGTACTTGGTGGAAATT

CATGGGCAAACTCGTAGTCGCTATTATTGTAGTGACCATCGCCCTTCTTCTCCTTGGAACCTTCCTTCCATTCCTAT

AA

4166.3

ATGAAAATAGATATAACAAATCAAGTTAAAGATGAATTTCTTATATCATTAAAAACCTTGATTTCCTATCCTTCAG

TACTCAATGAAGGAGAAAATGGAACACCTTTTGGACAAGCAATCCAAGATGTCCTAGAAAAAACTTTAGAGATTT

GTCGAGACATAGGTTTCACTACCTATCTTGACCCTAAAGGTTATTACGGATATGCAGAAATCGGTCAGGGAGCAG

AGCTTCTGGCCATTCTCTGTCATTTGGATGTTGTTCCATCAGGTGATGAAGCAGATTGGCAGACACCGCCATTTGA

AGCAACTATCAAAGACGGCTGGGTATTCGGACGTGGTGTCCAAGATGATAAAGGCCCTTCGCTCGCAGCTCTCTA

TGCAGTAAAAAGCTTGCTGGACCAAGGTATTCAGTTCAAAAAGCGCGTACGCTTTATCTTTGGTACCGATGAGGA

AACCCTCTGGCGCTGCATGGCACGCTACAATACCATCGAAGAACAGGCCAGTATGGGCTTTGCACCTGACTCATC

TTTTCCTCTGACCTATGCTGAAAAAGGGCTTCTACAGGTCAAACTTCATGGCCCTGGATCGGATCAACTAGAGCTT

GAAGTAGGAGGCGCCTTTAACGTTGTACCAGACAAGGCCAACTACCAAGGTCTCCTCTATGAACAGGTTTGTAAC

GGTCTCAAAGAAGCTGGTTATGATTACCAAACCACTGAACAAACCGTAACGGTTCTCGGAGTGCCAAAGCATGCT

AAGGATGCTAGTCAAGGTATCAATGCTGTCATCCGACTAGCTACCATTCTTGCTCCTCTCCAAGAACACCCTGCTC

TCAGTTTTCTTGCAACACAAGCAGGTCAAGACGGCACAGGAAGACAAATCTTTGGTGATATAGCAGATGAACCTT

CTGGTCACCTATCCTTTAATGTCGCAGGTCTCATGATCAATCATGAACGTTCTGAAATCCGTATTGACATTCGGAC

TCCTGTCTTAGCTGACAAGGAAGAACTAGTAGAGTTGCTTACAAGATGTGCACAAAACTACCAACTCCGCTACGA

AGAGTTTGACTATCTAGCGCCTCTATACGTCGCAGAAGACAGTAAACTCGTTAGCACACTGATGCAAATCTACCA

AGAAAAGACTGGCGATAACAGTCCTGCTATTTCATCCGGTGGTGCCACTTTTGCTCGCACCATGCCAAATTGTGTA

GCCTTCGGCGCCTTATTCCCAGGAGCGAAGCAGACAGAACATCAGGCAAATGAATGTGCCGTTCTAGAAGATTTG

TACCGTGCTATGGATATTTATGCCGAAGCCGTCTATCGACTTGCAACTTAA

4169.1

ATGTCTAATTCATTTGTCAAGTTGTTAGTCTCTCAATTATTTGCAAATTTAGCAGATATTTTCTTTAGAGTAACAAT

CATTGCTAACATATACATTATTTCAAAATCAGTAATTGCCACATCACTAGTTCCTATCTTAATAGGAATATCCTCTT

TTGTTGCGAGTCTTTTAGTTCCGTTGGTTACTAAAAGGTTAGCGCTAAATAGGGTTTTATCTTTATCTCAATTTGGA

AAGACTATATTATTGGCGATACTGGTAGGAATGTTTACCGTAATGCAATCCGTAGCGCCTTTGGTGACCTATCTAT

TTGTTGTTGCAATTTCCATACTAGATGGTTTTGCAGCACCCGTTTCCTATGCTATTGTGCCACGCTATGCGACCGAT

TTGGGTAAGGCTAATTCAGCCTTATCAATGACTGGTGAAGCTGTTCAATTGATAGGTTGGGGATTAGGTGGACTCT

TGTTTGCAACAATTGGTCTGTTACCTACCACGTGTATCAATTTAGTCTTGTATATCATTTCTAGCTTTCTGATGTTA

TTTCTTCCTAACGCTGAAGTGGAGGTGTTAGAGTCAGAAACTAATCTTGAAATTTTGCTCAAAGGTTGGAAGTTAG

TTGCTAGAAATCCTAGATTAAGACTTTTTGTATCAGCAAATTTATTGGAAATTTTTTCAAATACGATTTGGGTTTCT

TCCATTATACTTGTTTTTGTAACGGAGTTATTAAATAAAACGGAAAGTTACTGGGGATATTCTAATACAGCATACT

CTATTGGTATTATAATTAGTGGCTTAATTGCTTTTAGGCTATCTGAAAAGTTCCTTGCTGCTAAATGGGAACCCCA

ATTATTCACCCCAAATCTAAAAACCATCCAGAATCCTTGCCTTAGCTTAGATCCTGGATGGTTTCTTTTTCACCCA

ATGGGTGTTTTTTACTAGACAAAAAAGAGTTTCCCCTTTATGGTATAAGTGTAGAAAAAAACACAAAAAGAAAGG

AAACTCACATGAACAGTTTACCAAATCATCACTTCCAAAACAAGTCTTTTTACCAACTATCTTTCGATGGAGGTCA

TTTAACCCAGTATGGTGGTCTTATCTTTTTTCAGGAACTTTTTTCCCAGTTGAAACTAAAAGAGCGGATTTCTAAGT

ATTTAGTAACGAATGACCAACGCCGCTACTGTCGTTATTCGGATTCAGATATCCTTGTCCAGTTCCTCTTTCAACTG

TTAACAGGTTATGGAACGGACTATGCTTGTAAAGAATTGTCAGCTGATGCCTACTT

TCCAAAATTGTTGGAAGGAGGGCAGCTTGCTTCACAGCCAACCTTATCCCGTTTTCTTTCCAGAACTGACGAGGAA

ACAGTCCATAGTTTGCGATGCCTCAACCTTGAATTGGTCGAATTCTTTTTACAGTTTCACCAGCTAAACCAACTCA

TTGTAGATATCGATTCTACCCATTTCACAACTTATGGCAAGCAAGAAGGTGTTGCTTATAACGCCCACTATCGTGC

TCATGGCTATCATCCTCTTTATGCTTTCGAGGGGAAGACAGGTTATTGTTTCAATGCCCAGCTTCGTCCTGGTAATC

GTTATTGTTCTGAAGAGGCAGACAGCTTTATCACACCTGTTTTAGAACGGTTTAATCAACTTCTCTTTCGAATGGA

TAGTGGCTTTGCGACCCCAAAATTATACGATTTAATTGAAAAAACAGGGCAATACTACCTCATAAAACTCAAGAA

AAATACTGTTCTGAGCCGTCTTGGAGACCTTTCCCTCCCTTGCCCACAGGATGAGGACTTAACCATCTTGCCCCAC

TCCGCCTACTCAGAAACTCTCTATCAAGCAGGATCTTGGTCGCACAAGCGTCGTGTCTGCCAGTTCTCTGAACGAA

AAGAAGGAAACTTGTTCTACGATGTTATTTCTCTCGTTACAAATATGACGAGTGGAACAAGCCAAGACCAGTTTCA

GCTTTATCGTGGACGTGGTCAAGCCGAGAATTTCATCAAGGAGATGAAGGAGGGATTTTTTGGCGATAAAACGGA

TAGTTCAACCTTAATCAAAAACGAAGTTCGTATGATGATGAGCTGTATCGCCTACAATCTCTATCTTTTTCTCAAA

CATCTAGCTGGAGGTGACTTCCAAACTTTAACAATCAAACGCTTCCGCCATCTTTTTCTTCACGTGGTGGGAAAAT

GTGTTCGAACAGGACGCAAGCAGCTCCTCAAATTGTCTAGTCTCTATGCCTATTCCGAATTGTTTTCAGCACTTTA

TTCTAGGATTAGAAAAGTCAACCTGAATCTTCCTGTTCCTTATGAACCACCTAGAAGAAAAGCGTCGTTAATGATG

CATTAA

4169.3

ATGATGGAGTTTTTTCAACAGCTTCCTCATTTAGAGCCATATGGCAATCCTCAGTATTTTGTTTATGTGATTGCTGC

AACCTTGCCCATCTTTATAGGTCTCTTTTTCAAGAAACGCTTTGCCTGGTATGAAGTGTTGGTAAGTCTCTTCTTTA

TTGTCACCATGTTGGTGGGTGGAAAGACCAATCAACTAGCTGCCTTGGGTATTTACCTTTGCTGGGAAATATTGCT

CCTGCTTTTCTACAAGCATTATCGAAAAAGCAAGGATGGCAAGTGGGTCTTCTACTTAGTTAGTTTTCTGTCCCTA

CTTCCGATTATCTTTGTCAAGGTGCAACCAGCTATCAATGGAACGCAGTCTTTGCTTGGGTTCTTGGGAATTTCTTA

CCTGACCTTTCGTTCGGTTGGAATTGTCATCGAGCTGAGAGATGGAGTGATTAAGGATTTTACCCTCTGGGAATTC

CTCCGTTTCCTTCTCTTCATGCCAACTTTCTCGAGTGGTCCAATCGATCGCTTTAAGCGATTTAATGAAAATTATCA

GGCTATTCCTGAGCGAGATGAGTTGATGGATATGCTGGATGAATCTGTCCGCTATATCATGTGGGGCTTTTTGTAT

AAGTTTATCCTAGCTCATGTTTTAGGAGAG?ACCTTACTACCTCCTCTGAAGAATTTAGCCTTGCAGTCAGGTGGCT

TCTTTAATCTCTATGCCTTGGCAGTTATGTATACTTTTGGTCTGGAACTCTTCTTTGACTTTGCAGGTTATTCTATGT

TTGCTTTGGCCATCTCAAACTTGATGGGAATCCGTAGCCCTATCAACTTTAACAAG?CCCTTTTTATCAAGGGATTT

AAAGGAGTTTTGGAATCGCTGGCATATGAGTCTGTCCTTCTGGTTCCGTGACTTTGTCTTTATGCGAATGGTGATG

GTGTTAACCAGAAAGAAAGTCTTTAAAAATCGTAATGTAACCTCAAGCATGGCCTACATTGTAAATATGCTGATTA

TGGGATTTTGGCATGGTGTGACCTGGTACTATATCGCCTATGGACTCTTTCATGGACTAGGCTTGGTCATCAATGA

TGCCTGGGTTCGCAAGAAAAAAACGCTCAATAAGGAACGGAAAAAAGCAGGGAAGGCTGCCCTACCTGAGAATC

GCTGGATTCAGTTGCTTGGCATGGTTGTCACTTTCCATGTTGTCATGTTGTCATTCTTAATCTTTTCTGGATTCTTGA

ATAATCTATGGTTTAAAAAATAA

4169.4

ATGCTTAAACGCTTATGGATGATCTTCGGACCGGTCTTGATCGCTGGTTTGTTGGTTTTTCTGCTCATTTTCTTTTAT

CCTACTGAGATGCATCATAATCTAGGAGCTGAAAAGCGTTCAGCAGTGGCTACTACTATCGATAGTTTTAAGGAGC

GAAGTCAAAAAGTCAGAGCACTATCTGATCCAAATGTGCGTTTTGTTCCCTTCTTTGGCTCTAGTGAATGGCTTCG

TTTTGACGGTGCTCATCCTGCGGTATTAGCTGAGAAATACAATCGTTCCTACCGTCCTTATCTTTTAGGACAGGGG

GGAGCTGCATCGCTTAACCAATATTTTGGAATGCAACAGATGTTACCACAGCTGGAGAATAAACAAGTTGTGTAT

GTTATCTCACCTCAGTGGTTCAGTAAAAATGGCTATGATCCAGCAGCCTTCCAGCAGTATTTTAATGGAGACCAGT

TGACTAGTTTTCTGAAACATCAATCTGGGGATCAGGCTAGTCAATATGCAGCGACTCGCTTACTGCAACAGTTCCC

AAACGTAGCTATGAAGGACCTGGTTCAGAAGTTGGCAAGTAAAGAAGAATTGTCGACAGCAGACAATGAAATGAT

TGAATTATTGGCTCGTTTTAATGAACGCCAAGCTTCCTTTTTTGGTCAGTTTTCGGTTAGAGGCTATGTTAACTACG

ATAAGCATGTAGCTAAGTATTTAAAAATCTTGCCAGACCAGTTTTCTTATCAGGCAATAGAAGATGTTGTCAAAGC

AGATGCTGAAAAAAATACTTCCAATAATGAGATGGGAATGGAAAATTATTTCTATAATGAGCAGATCAAGAAGGA

TTTGAAGAAATTAAAGGATTCTCAGAAAAGCTTTACCTATCTCAAGTCGCCAGAGTATAATGACTTGCAGTTGGTT

TTAACACAGTTTTCTAAATCTAAGGTAAACCCGATTTTTATCATTCCACCTGTTAATAAAAAATGGATGAACTATG

CTGGTCTACGAGAGGATATGTACCAACAAACGGTGCAGAAGATTCGCTACCAGTTAGAAAGTCAAGGTTTTACCA

ATATAGCAGATTTTTCTAAGGACGGCGGGGAGCCTTTCTTTATGAAGGACACCATTCACCTTGGTTGGTTGGGTTG

GTTGGCTTTTGACAAGGCAGTTGATCCTTTCCTATCCAATCCCACACCAGCTCCGACTTACCATCTGAATGAGCGC

TTTTTCAGCAAAGATTGGGCGACTTATGATGGAGATGTCAAAGAATTTCAATAG

4169.6

ATGGAGAAAAACCTCAAGGCTTTGAAACAAACAACAGACCAAGAAGGCCCAGCAATTGAACCTGAAAAGGCAGA

GGATACCAAGACAGTCCAAAATGGTTACTTCGAGGATGCAGCTGTCAAGGACCGCACCTTGAGTGACTATGCAGG

TAACTGGCAATCAGTTTATCCTTTCCTTGAAGACGGCACGTTTGACCAAGTCTTTGACTACAAGGCTAAGTTGACT

GGTAAGATGACCCAGGCTGAGTACAAGGCTTACTATACAAAAGGCTATCATACAGATGTGACTAAGATTAACATT

ACTGATAATACTATGGAATTTGTTCAAGGTGGACAAAGCAAGAAATACACTTACAAGTATGTCGGTAAGAAAATT

TTGACTTACAAGAAAGGCAATCGTGGCGTGCGTTTCCTCTTTGAAGCCACAGATGCTGACGCTGGACAATTCAAGT

ATGTTCAGTTTAGTGACCACAATGTTGCCCCAGTTAAGGCAGAACATTTCCATATCTTCTTTGGAGGCACAAGCCA

AGAAGCCCTCTTTGAAGAAATGGACAACTGGCCAACCTACTACCCAGATAACCTATCTGGCCAAGAAATCGCCCA

AGAAATGTTGGCGCATTGA

4170.3

ATGAAAGATGGTCATTTGCTAGCCCATCATATTCGTTTGTTGAATGGGCGGATTTTTCAAAAGTTACTGAGTCAAG

ATCCTGAGGCTCTTTATAGGGGTGAACAGGGCAAGATTTTAGCGGTTTTATGGAATAGTGAAACTGGCTGCGCAA

CTGCGACAGATATCGCGCTTGCGACTGGACTTGCGAATAATACGCTGACGACTATGATAAAAAAGCTAGAGGAAC

AAAAGCTTGTAATTGTTAGTCCGTGTGGAAAAGACAAGCGTAAGAAGTATTTAGTTTTAACGGAGTTAGGCAAGT

CCCAGAAAGAAGTGGGGCATCGTGTCAGTCAGAAATTGGATACTATCTTTTACAAAGGATTTTCAGAGGAAGAAA

TTCACCAATTTGAAGGTTTTCAAGAAAGAATTTTGGCGAATCTGAAAGAGAAGGGAAATGAGGTTTAG

4170.4

ATGACTAATTTAATTGCAACTTTTCAGGATCGTTTTAGTGATTGGTTGACAGCTCTATCTCAACATTTGCAGTTGTC

GCTTTTGACCTTGTTACTAGCTATTTTGCTTGCGATTCCCTTGGCTGTTTTTCTTCGCTATCATGAGAAGCTGGCCG

ACTGGGTCTTGCAGATTGCAGGTATTTTCCAGACCATCCCGTCTCTGGCCTTGTTGGGGCTCTTTATCCCTTTGATG

GGAATTGGGACCTTGCCGGCTTTGACAGCTCTAGTGATTTATGCGATTTTCCCTATTTTGCAAAATACTATCACTG

GGCTGAAGGGAATTGATCCGAACCTGCAAGAGGCTGGGATTGCCTTTGGGATGACCAGATGGGAACGTCTCAAGA

AATTTGAAATTCCACTCGCCATGCCTGTTATCATGTCTGGGATTCGGACGGCAGCTGTTTTGATTATCGGTACGGC

AACCTTGGCGGCCTTGATTGGTGCAGGGGGACTAGGTTCCTTTATTCTTTTGGGAATTGACCGTAATAATGCCAGT

TTGATTTTGATTGGGGCACTTTCTTCTGCAGTGCTAGCCATTGCCTTTAACTTCCTACTAAAAGTGATGGAAAAAG

CAAAATTACGGACGATTTTCTCAGGTTTTGCCTTGGTGGCTTTATTACTGGGTCTGTCTTATAGTCCAGCTCTTTTG

GTTCAAAAAGAGAAGGAAAACTTGGTTATTGCTGGGAAAATAGGTCCAGAACCAGAAATTTTGGCCAATATGTAT

AAGTTGCTGATTGAAGAAAATACCAGCATGACTGCGACTGTTAAACCGAATTTTGGGAAGACAAGCTTCCTTTATG

AAGCTCTGAAAAAAGGCGATATTGACATCTATCCTGAATTTACTGGTACGGTGACTGAAAGTTTGCTTCAACCATC

ACCCAAGGTGAGTCATGAACCAGAACAGGTTTATCAGGTGGCGCGTGATGGCATTGCTAAGCAGGATCATCTAGC

CTATCTCAAACCCATGTCTTATCAAAACACCTATGCTGTAGCTGTTCCGAAAAAGATTGCTCAAGAATATGGCTTG

AAGACCATTTCAGACTTGAAAAAAGTGGAAGGGCAGTTGAAGGCAGGTTTTACACTCGAGTTTAACGACCGTGAA

GATGGAAATAAGGGCTTGCAATCAATGTATGGTCTCAATCTCAATGTAGCGACCATTGAGCCAGCCCTTCGCTATC

AGGCTATTCAGTCAGGGGATATTCAAATCACGGATGCCTATTCGACTGATGCGGAATTGGAGCGTTATGATTTACA

GGTCTTGGAAGATGACAAGCAACTCTTCCCACCTTATCAAGGGGCTCCACTCATGAAAGAAGCTCTTCTCAAGAA

ACACCCAGAGTTGGAAAGAGTTCTTAATACATTGGCTGGTAAGATTACAGAAAGCCAGATGAGCCAGCTCAACTA

CCAAGTCGGTGTTGAAGGCAAGTCAGCAAAGCAAGTAGCCAAGGAGTTTCTCCAAGAACAAGGTTTGTTGAAGAA

ATGA

4170.5

ATGATGCATACTTATTTGCAAAAGAAAATTGAAAATATCAAAACAACCCTAGGTGAAATGTCAGGTGGTTACCGT

CGTATGGTTGCGGCTATGGCTGATTTAGGATTTTCAGGAACTATGAAGGCTATCTGGGATGACCTCTTTGCCCATC

GTAGTTTTGCCCAGTGGATTTATTTGCTGGTTTTAGGAAGTTTTCCTCTCTGGCTGGAGTTGGTTTACGAACATCGT

ATTGTTGACTGGATTGGGATGATTTGTAGCTTGACAGGGATTATCTGTGTAATCTTTGTATCGGAAGGTCGAGCAA

GTAATTATCTTTTTGGCTTGATTAACTCTGTTATTTACCTTATTTTGGCCCTACAGAAAGGCTTTTATGGTGAGGTG

CTGACGACACTTTACTTCACAGTCATGCAGCCAATTGGACTTCTAGTTTGGATTTATCAGGCACAGTTTAAGAAGG

AAAAGCAGGAGTTTGTCGCGCGTAAACTGGACGGCAAGGGCTGGACAAAGTATCTTTCCATTAGTGTGCTTTGGT

GGTTGGCCTTTGGCTTCATTTATCAGTCTATTGGTGCCAATCGTCCCTATCGTGATTCAATCACAGATGCAACCAA

TGGGGTAGGGCAAATCCTCATGACAGCTGTTTACCGTGAACAGTGGATATTCTGGGCGGCTACCAATGTCTTTTCA

ATCTATCTCTGGTGGGGAGAAAGCCTGCAAATTCAAGGGAAATATCTAATTTATCTCATTAACAGTCTAGTTGGTT

GGTATCAATGGAGCAAGGCAGCTAAGCAGAATACTGATTTACTTAACTAG

4170.6

ATGAGAAATATGAAGGCAAAATATGCTGTTTGGGTGGCTTTTTTCTTAAATTTGACTTATGCCATTGTTGAGTTTAT

TGCAGGTGGAGTATTTGGTTCTAGCGCTGTTCTTGCTGACTCTGTGCATGACTTGGGAGATGCGATTGCAATTGGA

ATATCAGCTTTTCTAGAAACAATCTCCAATCGTGAAGAAGACAATCAGTACACCTTGGGCTATAAGCGGTTTAGCC

TGCTAGGAGCCTTGGTAACAGCTGTGATTCTCGTAACGGGCTCTGTTCTAGTCATTTTGGAAAATGTCACGAAGAT

TTTGCATCCGCAACCAGTCAATGATGAGGGGATTCTCTGGTTAGGAATTATTGCGATTACTATCAATCTGTTAGCG

AGTCTGGTGGTTGGTAAGGGAAAGACAAAGAATGAGTCTATTCTGAGTCTGCATTTTCTGGAAGATACGCTAGGG

TGGGTAGCTGTTATCCTGATGGCGATTGTTCTTCGATTTACGGACTGGTATATCCTAGATCCTCTTTTGTCCCTTGT

CATTTCTTTCTTTATTCTTTCAAAAGCCCTTCCACGTTTTTGGTCTACACTCAAGATTTTCTTGGATGCTGTGCCAG

AAGGTCTTGATATCAAGCAAGTAAAGAGTGGCCTGGAGCGATTGGACAATGTGGCCAGCCTTAATCAGCTTAATC

TCTGGACTATGGATGCTTTGGAAAAAAATGCCATTGTCCATGTTTGTCTAAAAGAAATGGAACATATGGAAACTTG

TAAAGAGTCTATTCGAATTTTCCTAAAAGATTGTGGTTTTCAAAATATTACCATTGAAATTGATGCTGACCTAGAA

ACTCACCAAACCCATAAGCGAAAGGTGTGTGACTTGGAACGGAGTTATGAGCATCAACATTAG

4170.8

ATGATTGAATACAAAAATGTAGCACTGCGCTACACAGAAAAGGATGTCTTGAGAGATGTCAACTTACAGATTGAG

GATGGGGAATTTATGGTTTTAGTAGGGCCTTCTGGGTCAGGTAAGACGACCATGCTCAAGATGATTAACCGTCTTT

TGGAACCAACTGATGGAAATATTTATATGGATGGGAAGCGCATCAAAGACTATGATGAGCGTGAACTTCGTCTTT

CTACTGGTTATGTTTTACAGGCTATTGCTCTTTTTCCAAATCTAACAGTTGCGGAAAATATTGCTCTCATTCCTGAA

ATGAAGGGGTGGAGCAAGGAAGAAATTACGAAGAAAACAGAAGAGCTTTTGGCTAAGGTTGGTTTACCAGTAGCC

GAGTATGGGCATCGCTTACCTAGTGAATTATCTGGTGGAGAACAGCAACGGGTCGGTATTGTCCGAGCTATGATTG

GTCAGCCCAAGATTTTCCTCATGGATGAACCCTTTTCGGCCTTGGATGCTATTTCGAGAAAACAGTTGCAGGTTCT

GACAAAAGAATTGCATAAAGAGTTTGGGATGACAACGATTTTTGTAACCCATGATACGGATGAAGCCTTGAAGTT

GGCGG?ACCGTATTGCTGTCTTGCAGGATGGAGAAATTCGCCAGGTAGCGAATCCCGAGACAATTTTAAAAGCGCC

TGCAACAGACTTTGTAGCAGACTTGTTTGGAGGTAGTGTTCATGACTAA

4171.1

ATGTCAGCAGTTGCTATTTCAGCTATGACCAAGGTTATGCAAGAAACCCACGGAAATCCTTCTAGTATTCATGGTC

ATGGTCGTCAAGCTGGCAAACTCTTGCGAGAAGCCCGTCAGGAACTAGCCCAGTTACTAAGGACAAAACCTCAAC

ATATCTTTTTCACTTCTGGTGGGACTGAAGGCAATAATACTACCATCATTGGCTACTGTCTTCGTCACCAAGAACA

AGGAAACATATCATCACAACTGCCATCGAGCACCATGCTGTCCTTGAAACAATTGATTACTTGGTTCAACACTTT

GGGTTTGAAGCAACCATTATCCAGCCAGAAAATCAAGAAATCACAGCCCAGCAAATTCAAAAGGCTTTACGTGAC

GATACGATTTTGGTTTCTACCATGTTTGTCAATAATGAGACAGGAAACCTACTGCCCATCGCTGAAATTGGCCAAA

TACTCAAGCAACACCCTGCTGCCTATCATGTTGATGCAGTTCAGGCTATTGGTAAAATCCCAATTCATTCAGAAGA

ATTGGGCATTGATTTTCTCACTGCTTCTGCCCACAAATTCCATGGTCCTAAGGGAATCGGTTTTCTCTACGCATCTA

GCATGGACTTTGATTCCTATCTACATGGCGGAGACCAGGAACAGAAAAAACGTGCAGGAACTGAAAATCTGCCTG

CCATTGTAGGCATGGTTGCAGCCCTAAAAGAAGACCTAGAAAAACAAGAAGAACATTTTCAACATGTACAAAATC

TAGAAACTGCCTTTCTGGCAGAGCTGGAGGGCATTCAGTATTACCTGAATAGAGGAAAACATCATCTCCCTTATGT

TCTCAATATTGGATTTCCTGGTCAGAAAAATGACCTCTTACTCCTTCGGCTAGATTTAGCTGGAATTTCAATCTCTA

CTGGCTCAGCCTGTACTGCAGGCGTTGTCCAATCCAGCCATGTTCTTGAAGCCATGTATGGCGCAAATTCAGAACG

CTTGAAGGAATCCCTTCGCATCAGTTTGTCGCCACAAAATACCGTTGAAGACCTACAAACCCTCGCAAAAACCTTA

AAAGAAATTATCGGAGGTTAG

4172.1

ATGTTATTCAAATTATCTAAGGAAAAAATAGAGCTAGGCTTATCTCGTTTATCGCCAGCCCGTCGTATTTTTTTGA

GTTTTGCCTTGGTCATTTTACTAGGCTCTCTTCTTTTGAGCTTGCCCTTTGTCCAAGTTGAAAGCTCACGAGCGACT

TATTTTGATCATCTTTTCACTGCTGTCTCTGCAGTCTGTGTGACGGGTCTCTCAACCCTTCCAGTAGCTCACACCTA

TAATATCTGGGGTCAAATAATCTGTTTGCTCTTGATTCAGATCGGTGGTCTAGGGCTCATGACCTTTATTGGGGTTT

TCTATATCCAGAGCAAGCAAAAGCTTAGTCTTCGTAGCCGTGCAACTATTCAGGATAGTTTTAGTTATGGAGAAAC

TCGATCTTTGAGAAAGTTTGTCTATTCTATTTTTCTCACGACCTTTTTGGTTGAGAGCTTGGGAGCTATTTTGCTTA

GTTTTCGCCTTATTCCTCAACTTGGCTGGGGACGTGGTCTTTTTAGTTCCATTTTTCTAGCGATCTCAGCCTTCTGT

AATGCCGGTTTTGATAATTTAGGGAGCACCAGTTTATTTGCTTTTCAGACCGATTTACTGGTCAATCTGGTGATTGC

AGGCTTGATTATTACAGGCGGCCTTGGTTTTATGGTCTGGTTTGATTTGGCTGGTCATGTAGGAAGAAAGAAAAAA

GGACGTCTGCACTTTCATACGAAGCTTGTACTATTATTGACTATAGGTTTGTTGTTATTTGGAACAGCAACTACTCT

CTTTCTTGAGTGGAACAATGCTGGAACGATTGGCAATCTCCCTGTTGCCGATAAGGTTTTAGTTAGCTTTTTTCAA

ACAGTGACGATGCGAACAGCTGGCTTTTCTACGATAGATTATACTCAGGCTCATCCTGTGACTCTTTTGATTTATA

TCTTACAGATGTTTCTAGGTGGGGCACCTGGAGGAACAGCTGGGGGACTCAAGATTACGACATTTTTTGTCCTCTT

GGTCTTTGCACGAAGTGAGCTTCTAGGCTTGCCTCATGCCAATGTTGCGAGACGAACGATCGCGCCGCGAACGGTT

CAAAAATCCTTTAGTGTCTTTATTATCTTTTTGATGAGCTTCTTGATAGGATTGATTCTGCTAGGGATAACAGCCAA

AGGCAATCCTCCCTTTATCCACCTCGTATTTGAAACCATTTCAGCTCTTAGTACAGTTGGTGTAACGGCAAATCTG

ACTCCTGACCTTGGGAAATTGGCTCTCAGTGTTATCATGCCACTTATGTTTATGGG

ACGAATTGGTCCCTTGACCTTGTTTGTTAGCTTGGCAGATTACCATCCAGAAAAGAAAGATATGATTCACTATATG

AAAGCAGATATTAGTATTGGTTAA

4172.2

ATGTCAGATCGTACGATTGGAATTTTGGGCTTGGGAATTTTTGGGAGCAGTGTCCTAGCTGCCCTAGCCAAGCAGG

ATATGAATATTATCGCTATTGATGACCACGCAGAGCGCATCAATCAGTTTGAGCCAGTTTTGGCGCGTGGAGTGAT

TGGTGACATCACAGATGAAGAATTATTGAGATCAGCAGGGATTGATACCTGCGATACCGTTGTAGTCGCGACAGG

TGAAAATCTGGAGTCGAGTGTGCTTGCGGTTATGCACTGTAAGAGTTTGGGGGTACCGACTGTTATTGCTAAGGTC

AAAAGTCAGACCGCTAAGAAAGTGCTAGAAAAGATTGGAGCTGACTCGGTTATCTCGCCAGAGTATGAAATGGGG

CAGTCTCTAGCACAGACCATTCTTTTCCATAATAGTGTTGATGTCTTTCAGTTGGATAAAAATGTGTCTATCGTGG

AGATGAAAATTCCTCAGTCTTGGGCAGGTCAAAGTCTGAGTAAATTAGACCTCCGTGGCAAATACAATCTGAATA

TTTTGGGTTTCCGAGAGCAGGAAAATTCCCCATTGGATGTTGAATTTGGACCAGATGACCTCTTGAAAGCAGATAC

CTATATTTTGGCAGTCATCAACAACCAGTATTTGGATACCCTAGTAGCATTGAATTCGTAA

4172.3

ATGAAGTTATTGTCTATCGCAATTTCTAGCTATAATGCAGCAGCCTATCTTCATTACTGTGTGGAGTCGCTAGTGA

TTGGTGGTGAGCAAGTTGGGATTTTGATTATCAATGACGGGTCTCAGGATCAGACTCAGGAAATCGCTGAGTGTTT

AGCTAGCAAGTATCCTAATATCGTTAGAGCCATCTATCAGGAAAATAAATGCCATGGCGGTGCGGTCAATCGTGG

CTTGGTAGAGGCTTCTGGGCGCTATTTTAAAGTAGTTGACAGTGATGACTGGGTGGATCCTCGTGCCTACTTGAAA

ATTCTTGAAACCTTGCAGGAACTTGAGAGCAAAGGTCAAGAGGTGGATGTCTTTGTGACCAATTTTGTCTATGAAA

AGGAAGGGCAGTCTCGTAAGAAGAGTATGAGTTACGATTCAGTCTTGCCTGTTCGGCAGATTTTTGGCTGGGACCA

GGTCGGAAATTTCTCCAAAGGCCAGTATACCATGATGCACTCGCTGATTTATCGGACAGATTTGTTGCGTGCTAGC

CAGTTCTAA

4172.4

ATGAAATTCAATCCAAATCAAAGATATACTCGTTGGTCTATTCGCCGTCTCAGTGTCGGTGTTGCCTCAGTTGTTG

TGGCTAGTGGCTTCTTTGTCCTAGTTGGTCAGCCAAGTTCTGTACGTGCCGATGGGCTCAATCCAACCCCAGGTCA

AGTCTTACCTGAAGAGACATCGGGAACGAAAGAGGGTGACTTATCAGAAAAACCAGGAGACACCGTTCTCACTCA

AGCGAAACCTGAGGGCGTTACTGGAAATACGAATTCACTTCCGACACCTACAGAAAGAACTGAAGTGAGCGAGGA

AACAAGCCCTTCTAGTCTGGATACACTTTTTGAAAAAGATGAAGAAGCTCAAAAAAATCCAGAGCTAACAGATGT

CTTAAAAGAAACTGTAGATACAGCTGATGTGGATGGGACACAAGCAAGTCCAGCAGAAACTACTCCTGAACAAGT

AAAAGGTGGAGTGAAAGAAAATACAAAAGACAGCATCGATGTTCCTGCTGCTTATCTTGAAAAAGCTGAAGGGAA

AGGTCCTTTCACTGCCGGTGTAAACCAAGTAATTCCTTATGAACTATTCGCTGGTGATGGTATGTTAACTCGTCTA

TTACTAAAAGCTTCGGATAATGCTCCTTGGTCTGACAATGGTACTGCTAAAAATCCTGCTTTACCTCCTCTTGAAG

GATTAACAAAAGGGAAATACTTCTATGAAGTAGACTTAAATGGCAATACTGTTGGTAAACAAGGTCAAGCTTTAA

TTGATCAACTTCGCGCTAATGGTACTCAAACTTATAAAGCTACTGTTAAAGTTTACGGAAATAAAGACGGTAAAGC

TGACTTGACTAATCTAGTTGCTACTAAAAATGTAGACATCAACATCAATGGATTAGTTGCTAAAGAAACAGTTCAA

AAAGCCGTTGCAGACAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCTAGAAAAAGCCAAGGGTGAAGGT

CCATTCACAGCAGGTGTCAACCATGTGATTCCATACGAACTCTTCGCAGGTGATGGCATGTTGACTCGTCTCTTGC

TCAAGGCATCTGACAAGGCACCATGGTCAGATAACGGCGACGCTAAAAACCCAGCCCTATCTCCACTAGGCGAAA

ACGTGAAGACCAAAGGTCAATACTTCTATCAAGTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAAACAAGCGC

TCATTGACCAGTTCCGAGCAAATGGTACTCAAACTTACAGCGCTACAGTCAATGTCTATGGTAACAAAGACGGTA

AACCAGACTTGGACAACATCGTAGCAACTAAAAAAGTCACTATTAACATAAACGGTTTAATTTCTAAAGAAACAG

TTCAAAAAGCCGTTGCAGACAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCTAGAAAAAGCCAAGGGTG

AAGGTCCATTCACAGCAGGTGTCAACCATGTGATTCCATACGAACTCTTCGCAGGTGATGGTATGTTGACTCGTCT

CTTGCTCAAGGCATCTGACAAGGCACCATGGTCAGATAACGGTGACGCTAAAAACCCAGCCCTATCTCCACTAGG

TGAAAACGTGAAGACCAAAGGTCAATACTTCTATCAATTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAAACA

AGCGCTCATTGACCAGTTCCGAGCAAACGGTACTCAAACTTACAGCGCTACAGTCAATGTCTATGGTAACAAAGA

CGGTAAACCAGACTTGG?ACAACATCGTAGCAACTAAAAAAGTCACTATTAACATAAACGGTTTAATTTCTAAAGA

AACAGTTCAAAAAGCCGTTGCAGACAACGTTAAGACAGTATCGATGTTCCAGCAGCCTACCTAG

4172.5

ATGAAACTAAAAAGTTATATTTTGGTTGGATATATTATTTCAACCCTCTTAACCATTTTGGTTGTTTTTTGGGCTGT

TCAAAAAATGCTGATTGCGAAAGGCGAGATTTACTTTTTGCTTGGGATGACCATCGTTGCCAGCCTTGTCGGTGCT

GGGATTAGTCTCTTTCTCCTATTGCCAGTCTTTACGTCGTTGGGCAAACTCAAGGAGCATGCCAAGCGGGTAGCGG

CCAAGGATTTTCCTTCAAATTTGGAGGTTCAAGGTCCTGTAGAATTTCAGCAATTAGGGCAAACTTTTAATGAGAT

GTCCCATGATTTGCAGGTAAGCTTTGATTCCTTGGAAGAAAGCGAACGAGAAAAGGGCTTGATGATTGCCCAGTT

GTCGCATGATATTAAGACTCCTATCACTTCGATCCAAGCGACGGTAGAAGGGATTTTGGATGGGATTATCAAGGA

GTCGGAGCAAGCTCATTATCTAGCAACCATTGGACGCCAGACGGAGAGGCTCAATAAACTGGTTGAGGAGTTGAA

TTTTTTGACCCTAAACACAGCTAGAAATCAGGTGGAAACTACCAGTAAAGACAGTATTTTTCTGGACAAGCTCTTA

ATTGAGTGCATGAGTGAATTTCAGTTTTTGATTGAGCAGGAGAGAAGAGATGTCCACTTGCAGGTAATCCCAGAGT

CTGCCCGGATTGAGGGAGATTATGCTAAGCTTTCTCGTATCTTGGTGAATCTGGTCGATAACGCTTTTAAATATTC

TGCTCCAGGAACCAAGCTGGAAGTGGTGGCTAAGCTGGAGAAGGACCAGCTTTCAATCAGTGTGACCGATGAAGG

GCAGGGTATTGCCCCAGAGGATTTGGAAAATATTTTCAAACGCCTTTATCGTGTCGAAACTTCGCGTAACATGAAG

ACAGGTGGTCATGGATTAGGACTTGCGATTGCGCGTGAATTGGCCCATCAATTGGGTGGGGAAATCACAGTCAGC

AGCCAGTACGGTCTAGGAAGTACCTTTACCCTCGTTCTCAACCTCTCTGGTAGTGAAAATAAAGCCTAA

4172.6

ATGTTTGGTCAAACGGCTCAACATGGTCTTACGAATAGCCTGAAAGACTTCTGGATTTTTCTGCTGAATATAGGTC

CACAATTGGCGTTTTTTTGCCAGATGCTCCGCTGTTCCAGATCGGTTGAGCAGGGTACTGGAAATCACCGTCGTGA

GTTCAATATGATTCAGCAGATATTCTCGCATTTTGGGATGACTCACTTGGGACAAATCAAGTTGGTCTATCAAGAG

TCGATTGACCTTGAGTTGCTGGTCAATGCACTTAATCATCACTTGCTCATTGACAGACTGGTCCTCACGCCCAATC

AAATAACGATAGAAATCGACAGGCAGATAGTACATGGTCTTGACCTGCTGAAGGGGCGTAAAGACAAAGAGATTA

TCGACATAAAAAGTATGTTCAGGCAGTTAGAACTGGCTAGCACGCAACAAATCTGTCCGATAAATCAGCGAGTGC

ATCATGGTATACTGGCCTTTGGAGAAATTTCCGACCTGGTCCCAGCCAAAAATCTGCCGAACAGGCAAGACTGA

4174.1

ATGGAACATTTAGCAACTTATTTTTCAACCTATGGAGGAGCTTTCTTCGCTGCATTGGGAATTGTATTGGCGGTTG

GATTAAGCGGTATGGGGTCTGCTTATGGAGTTGGTAAGGCTGGGCAATCTGCCGCAGCTTTACTGAAAGAACAGC

CTGAAAAGTTTGCCTCAGCTTTGATATTGCAATTATTGCCCGGAACACAAGGATTATATGGTTTTGTTATTGGAAT

TTTAATTTGGTTGCAATTAACTCCAGAACTTCCTTTAGAAAAAGGCGTTGCTTATTTCTTTGTAGCTCTTCCAATTG

CTATTGTAGGATACTTTTCAGCTAAGCATCAAGGAAATGTAGCAGTAGCGGGAATGCAAATCTTGGCTAAAAGAC

CAAAAGAATTCATGAAGGGAGCAATTTTAGCTGCCATGGTAGAAACCTATGCAATTCTTGCTTTTGTCGTATCATT

CATTTTGACCCTTCGTGTATAA

4175.2

ATGTTAAAATCAGAAAAAACAATCACGTTATCAAATGTTAAATGAAGAATTGTCCTTCCTATTGGAAGGCGAAACC

AATGTTTGGCTAATCTTTCCAACGCCAGTGCTCTCATAAAATCACGTTTTCCTAATACCGTATTTGCAGGCTTTTA

TTTGTTCG?ATGGAAAGGAATTGGTTTTAGGCCCCTTCCAAGGAGGTGTTTCCTGCATCCGTATTGCACTAGGCAAG

GGTGTTTGTGGTGAGGCAGCTCACTTTCAGGAAACTGTTATTGTTGGAGATGTGACGACCTATCTCAACTATATTT

CTTGTGATAGTCTAGCTAAAAGTGAAATTGTGGTGCCGATGATGAAGAATGGTCAGTTACTTGGAGTTCTG?GATCT

GGATTCTTCAGAGATTGAGGATTACGATGCTATGGATCGAGATTATTTGGAACAATTTGTCGCTATTTTGCTTGAA

AAGACAGCATGGGACTTTACGATGTTTGAGGAAAAATCTTAA

4175.3

ATGTCAGTATTAGAGATCAAAGATCTTCACGTTGAGATTGAAGGAAAAGAAATTTTAAAAGGGGTTAACCTGACC

CTGAAAACAGGAGAAATTGCCGCTATCATGGGACCAAATGGTACAGGTAAATCGACTCTTTCTGCCGCTATCATG

GGAAATCCAAACTATGAAGTAACTAAAGGTGAAGTTTTGTTTGATGGCGTAAACATCCTTGAGTTGGAAGTGGAT

GAGCGTGCGCGTATGGGACTTTTCCTTGCTATGCAATACCCATCAGAAATCCCTGGAATTACCAATGCTGAGTTTC

TTCGTGCCGCTATGAATGCGGGTAAAGAAGATGATGAGAAGATTTCAGTTCGTGAGTTTATTACTAAGCTAGATGA

AAAAATGGAATTGCTCAACATGAAAGAAGAAATGGCAGAGCGTTACCTCAACGAAGGCTTCTCTGGTGGTGAGAA

AAAACGCAATGAAATTCTTCAACTTTTGATGTTGGAGCCAACATTTGCTCTTTTGGACGAGATTGACTCAGGTCTT

GATATTGACGCTCTTAAAGTTGTGTCTAAAGGTGTCAATGCCATGCGTGGTGAAGGTTTTGGTGCTATGATCATCA

CTCACTACCAACGTCTTTTGAACTATATCACACCTGATGTGGTACACGTGATGATGGAAGGTCGTGTTGTCCTTTC

TGGTGGTCCAGAATTGGCTGCGCGTTTGGAACGTGAAGGATACGCAAAATTAGCTGAAGAACTTGGCTACGACTA

CAAGGAAGAATTGTAA

4174.4

ATGCCCTACAAAGACAAAGGAGTTTTTCAATGGCACTTTCTAAACTAGATAGCCTTTATATGGCAGTGGTAGCAG

ACCATTCGAAAAATCCACATCACCAAGGGAAGTTAGAAGATGCTGAGCAAATCAGTCTCAACAATCCGACTTGTG

GGGATGTCATCAACCTCTCTGTCAAGTTTGATGCAGAGGACCGTTTGGAAGATATTGCTTTTCTAAATTCAGGATG

CACGATTTCAACTGCTTCTGCTAGTATGATGACAGATGCCGTTTTAGGAAAAACCAAACAAGAAATTTTAGAACTG

GCGACTATTTTTTCTGAAATGGTTCAAGGGCAAAAAGATGAGCGTCAAGACCAACTTGGAGACGCGGCATTCTTG

TCAGGTGTTGCCAAATTCCCTCAAAGAATCAAGTGTGCAACCCTAGCTTGG?AATGCCCTTAAGAAAACAATTGAA

AATCAAGAAAAACAGTAA

4175.5

ATGAAAATTCAAGACCTATTGAGAAAAGATGTCATGTTGCTAGATTTGCAGGCAACTGAAAAAACAGCTGTCATC

GACGAGATGATTAAAAATTTGACAGACCACGGTTATGTAACAGATTTTGAAACATTTAAAGAAGGAATTTTGGCG

CGTGAAGCTTTGACTTCTACTGGTTTGGGTGATGGAATCGCAATGCCTCACAGCAAAAACGCTGCTGTCAAAGAA

GCGACAGTTCTATTTGCTAAGTCAAATAAGGGTGTTGACTACGAGAGCTTGGATGGACAAGCAACTGACCTCTTCT

TCATGATTGCAGCTCCAGAAGGTGCCAATGATACTCACTTGGCAGCCTTGGCAGAATTGTCTCAATACTTGATGAA

AGACGGTTTTGCAGACAAACTTCGTCAAGCAACATCTGCAGACCAAGTTATCGAACTTTTTGACCAAGCTTCAGAA

AAAACTGAGGAACTTGTTCAAGCACCTGCTAATGACTCTGGTGACTTTATCGTAGCTGTTACAGCTTGTACAACAG

GTATTGCCCACACTTACATGGCCCAAGAAGCCCTTCAAAAAGTAGCTGCTGAAATGGGGGTTGGTATCAAGGTCG

AAACCAACGGTGCTAGCGGTGTTGGAAATCAACTAACTGCAGAAGATATCCGTAAGGCTAAAGCTATTATCATTG

CAGCAGACAAGGCCGTTGAAATGGATCGATTTGATGGAAAACCATTGATCAATCGTCCAGTTGCTGACGGTATCC

GTAAGACAGAAGAGCTAATTAACTTGGCTCTTTCAGGAGATACTGAAGTCTACCGTGCCGCTAATGGTGCCAAAG

CTGCAACAGCCTCTAACGAAAAACAAAGCCTTGGTGGTGCCTTGTACAAACACTTGATGAGTGGTGTATCTCAAA

TGTTACCATTCGTTATCGGTGGTGGTATCATGATTGCCCTTGCCTTCTTGATTGACGGTGCTTTGGGTGTTCCAAAT

GAAAACCTTGGCAATCTTGGTTCTTACCATGAGTTAGCTTCTATGTTCATGAAAATTGGTGGAGCTGCCTTTGGTTT

GATGCTTCCAGTCTTTGCGGGTTATGTTGCCTACTCTATTGCTGAAAAACCGGGTTTGGTAGCAGGTTTCGTGGCT

GGTGCTATTGCCAAAGAAGGTTTTGCCTTTGGTAAAATTCCTTATGCCGCAGGTGGTGAAGCAACTTCAACTCTTG

CAGGTGTCTCATCTGGTTTCCTAGGTGCCCTTGTTGGTGGATTTATCGCAGGTGCCTTGGTTCTTGCCATCAAGAAA

TACGTTAAAGTTCCTCGTTCACTCGAAGGTGCTAAATCAATCCTTCTATTGCCACTTCTTGGAACAATCTTGACAG

GATTTGTTATGCTAGCTGTGAATATCCCAATGGCTGCAATCAACACTGCTATGAATGACTTCCTAGGCGGTCTTGG

AGGAGGTTCAGCTGTCCTTCTTGGTATCGTCCTTGGTGGAATGATGGCTGTTGACATGGGTGGACCAGTTAATAAA

GCAGCTTATGTCTTTGGTACAGGTACGCTTGCAGCAACTGTTTCTTCAGGTGGTTCTGTAGCCATGGCAGCAGTTA

TGGCTGGAGGAATGGTGCCACCACTTGCAATCTTTGTCGCAACTCTTCTTTTCAAAGATAAATTTACTAAGGAAGA

ACGTAACTCTGGTTTGACAAACATCATCATGGGCTTGTCATTTATCACTGAGGGAGCGATTCCATTTGGTGCCGCT

GACCCAGCTCGTGCGATTCCAAGCTTCATCCTTGGTTCAGCAGTAGCAGGTGGACTCGTTGGTCTTACTGGTATCA

AACTCATGGCGCCACACGGAGGAATCTTCGTTATCGCCCTTACTTCAAATGCTCTCCTTTACCTCGTTTCTGTCTTG

GTAGGAGCAATCGTAAGTGGTGTGGTTTATGGTTACCTACGCAAACCACAAGCATAA

4175.6

ATGGCAAACAAGAATACAAGTACAACAAGACGGAGACCGTCTAAAGCAGAACTGGAAAGAAAAGAAGCGATTCA

ACGAATGTTGATTTCGTTAGGAATTGCGATTTTATTGATTTTCGCAGCCTTCAAATTAGGGGCTGCAGGTATAACC

CTTTATAATTTAATTCGCTTGCTAGTGGGTAGCCTAGCTTATCTGGCGATATTCGGCCTATTAATCTATCTCTTCTT

TTTCAAGTGGATACGAAAACAGGAAGGACTCTTATCTGGCTTTTTCACCATATTTGCTGGCTTACTCTTGATTTTTG

AGGCCTACTTGGTTTGGAAATATGGTTTGGACAAGTCCGTTCTAAAAGGGACCATGGCTCAGGTTGTGACAGATCT

GACTGGTTTTCGAACGACTAGCTTTGCTGGAGGGGGCTTGATCGGGGTCGCTCTTTATATTCCAACAGCCTTTCTC

TTTTCAAATATCGGAACTTACTTTATTGGTTCTATCTTGATTTTAGTGGGTTCTCTCCTAGTCAGCCCTTGGTCTGTT

TACGATATTGCTGAATTTTTCAGTAGAGGCTTTGCCAAATGGTGGGAAGGGCACGAGCGTCGAAAAGAGGAACGC

TTTGTCAAACAAGAAGAAAAAGCTCGCCAAAAGGCTGAGAAAGAGGCTAGATTAGAACAAGAAGAGACTGAAAA

AGCCTTACTCGATTTGCCTCCTGTTGATATGGAAACGGGTGAAATTCTGACAGAGGAAGCTGTTCAAAATCTTCCA

CCTATTCCAGAAGAAAAGTGGGTGGAACCAGAAATCATCCTGCCTCAAGCTGAACTTAAATTCCCTGAACAGGAA

GATGACTCAGATGACGAAGATGTTCAGGTCGATTTTTCAGCCAAAGAAGCCCTTGAATACAAACTTCCAAGCTTA

CAACTCTTTGCACCAGATAAACCAAAAGATCAGTCTAAAGAGAAGAAAATTGTCAGAGAAAATATCAAAATCTTA

GAAGCAACCTTTGCTAGCTTTGGTATTAAGGTAACAGTTGAACGGGCCGAAATTGGGCCATCAGTGACCAAGTAT

GAAGTCAAGCCGGCTGTTGGTGTAAGGGTCAACCGCATTTCCAATCTATCAGATGACCTCGCTCTAGCCTTGGCTG

CCAAAGATGTCCGGATTGAAGCACCAATCCCTGGGAAATCCCTAATCGGAATTGAAGTGCCCAACTCCGATATTG

CCACTGTATCTTTCCGAGAACTATGGGAACAATCGCAAACGAAAGCAGAAAATTTCTTGGAAATTCCTTTAGGGA

AGGCTGTTAATGGAACCGCAAGAGCTTTTGACCTTTCTAAAATGCCCCACTTGCTAGTTGCAGGTTCAACGGGTTC

AGGGAAGTCAGTAGCAGTTAACGGCATTATTGCTAGCATTCTCATGAAGGCGAGACCAGATCAAGTTAAATTTAT

GATGGTCGATCCCAAGATGGTTGAGTTATCTGTTTACAATGATATTCCCCACCTCTTGATTCCAGTCGTGACCAAT

CCACGCAAAGCCAGCAAGGCTCTGCAAAAGGTTGTGGATGAAATGGAAAACCGTTATGAACTCTTTGCCAAGGTG

GGAGTTCGGAATATTGCAGGTTTTAATGCCAAGGTAGAAGAGTTCAATTCCCAGTCTGAGTACAAGCAAATTCCG

CTACCATTCATTGTCGTGATTGTGGATGAGTTGGCTGACCTCATGATGGTGGCCAGCAAGGAAGTGGAAGATGCTA

TCATCCGTCTTGGGCAGAAGGCGCGTGCTGCAGGTATCCACATGATTCTTGCAACTCAGCGTCCATCTGTTGATGT

CATCTCTGGTTTGATTAAGGCCAATGTTCCATCTCGTGTAGCATTTGCGGTTTCATCAGGAACAGACTCCCGTACG

ATTTTGGATGAAAATGGAGCAGAAAAACTTCTTGGTCGAGGAGACATGCTCTTTAAACCGATTGATGAAAATCAT

CCAGTTCGTCTCCAAGGCTCCTTTATCTCGGATGACGATGTTGAGCGCATTGTGAACTTCATCAAGACTCAGGCAG

ATGCAGACTACGATGAGAGTTTTGATCCAGGTGAGGTTTCTGAAAATGAAGGAGAATTTTCGGATGGAGATGCTG

GTGGTGATCCGCTTTTTGAAGAAGCTAAGTCTTTGGTTATCGAAACACAGAAAGCCAGTGCGTCTATGATTCAGCG

TCGTTTATCAGTTGGATTTAACCGTGCGACCCGTCTCATGGAAGAACTGGAGATAGCAGGTGTCATCGGTCCAGCT

GAAGGTACCAAACCTCGAAAAGTGTTACAACAATAA

4176.1

ATGAGTTATTTTAAAAAATATAAATTCGATAAATCCCAGTTCAAACTTGGTATGCGAACCTTTAAAACAGGTATTG

CTGTTTTTCTAGTTCTCTTGATTTTTGGCTTTTTTGGCTGGAAAGGTCTTCAAATTGGTGCTTTGACAGCCGTTTTTA

GCCTGAGGGAGAGTTTTGATGAGAGTGTTCATTTTGGGACTTCGCGTATTCTAGGAAATAGTATCGGTGGACTCTA

TGCCTTGGTCTTCTTCTTATTAAATACCTTTTTCCACGAAGCCTTTTGGGTGACCTTGGTAGTTGTTCCAATCTGCA

CCATGTTAACCATTATGACAAATGTAGCCATGAATAACAAAGCAGGGGTTATTGGTGGTGTAGCAGCTATGTTAAT

CATTACCCTATCAATTCCAAGTGGTGAGACAATTTTGTACGTGTTTGTGCGTGTATTAGAAACGTTTATGGGAGTT

TTTGTCGCAATTATCGTAAATTACGATATTGATCGTATTCGTCTCTTTTTAGAGAAAAAAGAAAAATAA

4178.2

ATGAATAAATCAGAACACCGCCACCAACTTATACGCGCTCTTATCACAAAAAACAAGATTCATACACAGGCTGAG

TTGCAAGCCCTTCTTGCTGAGAACGACATTCAAGTAACCCAGGCAACCCTCTCACGCGACATCAAAAATATGAAC

CTATCAAAAGTCCGCGAAGAAGATAGCGCTTATTATGTTCTTAACAATGGTTCCATCTCAAAATGGGAAAAACGTC

TCGAACTCTACATGGAAGACGCCCTTGTCTGGATGCGCCCAGTTCAACACCAAGTCCTACTAAAAACCCTTCCTGG

ACTGGCTCAATCCTTTGGTTCTATCATTGATACTTTGAGCTTCCCTGACGCTATCGCTACCCTTTGTGGTAATGATG

TCTGTCTTATCATCTGTGAAGATGCAGATACTGCTCAAAAGTGCTTTGAAGAACTGAAAAAATTCGCCCCACCATT

TTTCTTTGAAGAATAA

4179.1

ATGAAAAGTATAAAATTAAATGCTCTATCTTACATGGGAATTCGTGTCTTGAATATTATTTTTCCCATCCTAACTGG

AACCTATGTCGCGCGTGTCTTGGACCGAACTGACTATGGTTACTTCAACTCAGTCGACACTATTTTGTCATTTTTCT

TGCCCTTTGCAACTTATGGTGTCTATAACTACGGTTTAAGGGCTATCAGTAATGTCAAGGATAACAAAAAAGATCT

TAACAGAACCTTTTCTAGTCTTTTTTATTTGTGCATCGCTTGTACGATTTTGACCACTGCTGTCTATATCCTAGCCT

ATCCTCTCTTCTTTACTTGATAATCCAATCGTCAAAAAGGTCTACCTTGTTATGGGGATTCAACTCATTGCCCAGATT

TTTTCAATCGAATGGGTCAATGAAGCTCTGGAAAATTACAGTTTTCTCTTTTACAAAACTGCCTTCATCCGTATCCT

GATGCTGGTCTCTATTTTCTTATTTGTTAAAAATGAACACGATATTGTTGTCTATACACTTGTGATGAGTTTATCGA

CGCTGATTAACTACCTGATTAGTTATTTTTGGATTAAAAGAGACATCAAACTTGTTAAAATTCACCTAAGTGATTT

TAAACCACTCTTTCTCCCTCTGACAGCCATGTTAGTCTTTGCCAATGCCAATATGCTCTTCACTTTTTTAGATCGCC

TCTTCCTCGTTAAAACAGGGATTGATGTCAACGTTAGTTACTATACCATAGCTCAGCGAATTGTGACCGTTATAGC

TGGGGTTGTAACAGGTGCAATTGGAGTGAGTGTGCCTCGTCTCAGTTACTATCTGGGGAAAGGAGACAAAGAAGC

CTATGTTTCTCTGGTTAATAGAGGTAGTCGAATCTTTAACTTCTTTATCATTCCACTGAGTTTTGGACTCATGGTTT

TAGGACCAAATGCCATCCTACTTTACGGTAGTGAAAAATATATCGGAGGCGGCATCTTGACCTCTCTCTTCGCTTT

TCGTACGATTATCCTGGCCTTAGATACCATTCTTGGTTCCCAAATTCTCTTTACCAATGGCTATGAAAAACGTATC

ACAGTCTATACAGTCTTTGCTGGGCTACTCAATTTGGGCTTGAATAGTCTCCTTTTTTTCAACCATATCGTGGCTCC

TGAATACTACTTACTGACAACTATGCTATCAGAGACTTCTCTACTTGTTTTCTATATCATTTTCATCCATAGAAAAC

AACTCATCCACTTGGGACATATCTTTAGCTATACTGTTCGATACTCTCTCTTTTCACTTTCCTTTGTAGCAATTTATT

TCCTGATTAATTTCGTGTATCCTGTAGATATGGTCATTAATTTGCCATTTTTGATTA

ATACTGGTTTGATTGTCTTGCTATCAGCTATCTCTTATATTAGTCTACTTGTCTTCACAAAAGATAGCATTTTCTAT

GAATTTTTAAACCATGTCCTAGCCTTAAAAAATAAATTTAAAAAATCATAG

4179.2

ATGAAACAACTAACCGTTGAAGATGCCAAACAAATTGAATTAGAAATTTTGGATTATATTGATACTCTCTGTAAAA

AGCACAATATCAACTATATTATTAACTACGGTACTCTGATTGGGGCGGTTCGACATGAGGGCTTTATCCCTTGGGA

CGACGATATTGATCTGTCCATGCCTAGAGAAGACTACCAACGATTTATTAACATTTTTCAAAAGGAAAAAAGCAA

GTATAAGCTCCTATCCTTAGAAACTGATAAGAACTACTTTAACAACTTTATCAAGATAACCGACAGTACGACTAAA

ATTATTGATACTCGAAATACAAAAACCTATGAGTCTGGTATCTTTATCGATATTTTCCCTATAGATCGCTTTGATGA

TCCTAAGGTCATTGATACTTGTTATAAACTGGAAAGCTTCAAACTGCTGTCTTTCAGTAAACATAAAAATATTGTC

TATAAGGATAGCCTTTTAAAAGATTGGATACGAACAGCCTTCTGGTTACTCCTTCGACCGGTTTCTCCTCGTTATTT

TGCAAATAAAATCGAGAAAGAAATTCAAAAATATAGTCGTGAAAATGGGCAATATATGGCTTTTATCCCTTCAAA

ATTTAAGGAAAAGGAAGTCTTCCCAAGTGGTACCTTTGATAAAACAATCGATTTACCCTTTGAGAATTTAAGCCTT

CCTGCACCTGAAAAATTTGATACTATTTTGACACAATTTTATGGAGATTATATGACCCTACCACCAGAAGAAAAAC

GCTTCTACAGTCATGAATTTCACGCTTATAAATTGGAGGATTAG

4179.3

ATGATAAAAATCAATCATCTAACCATCACACAAAACAAAGATTTACGAGATCTTGTATCTGACCTAACCATGACC

ATCCAAGACGGGGAAAAGGTTGCTATTATTGGTGAAGAAGGAAATGGCAAATCAACCTTACTTAAAATTTTAATG

GGGGAAGCTTTGTCTGATTTCACTATCAAGGGAAACATCCAATCTGACTATCAGTCACTGGCCTACATTCCTCAAA

AAGTCCCTGAGGACCTAAAAAAGAAAACTTTACACGACTACTTCTTTTTAGATTCTATTGATTTAGACTACAGTAT

CCTCTATCGTTTGGCGGAGGAATTGCATTTTGATAGCAATCGTTTCGCAAGTGACCAAGAGATTGGCAATCTATCA

GGGGGCGAAGCTTTGAAAATTCAGCTTATCCATGAGTTAGCCAAACCCTTTGAGATTCTATTTTTAGATGAACCTT

CAAATGACCTAGACCTTGAGA?CAGTTGATTGGCTAAAAGGCCAGATTCAAAAGACCAGGCAAACCGTTATTTTCA

TTTCCCATGATGAAGACTTTCTTTCTGAAACGGCAGACACTATTGTTCACTTGCGACTGGTCAAACACCGTAAAGA

AGCGGAAACGCTAGTAGAGCATTTAGACTATGATAGCTATAGTGAGCAGAGAAAGGCTAATTTTGCCAAACAAAG

TCAGCAAGCTGCTAACAACCAAAGAGCCTACGATAAAACCATGGAAAAACATCGGAGAGTTAAGCAAAATGTAG

AAACTGCGCTTCGAGCTACCAAAGATAGTACTGCCGGTCGCCTATTGGCTAAAAAGATGAAAACTGTCCTCTCAC

AAGAAAAACGCTACGAAAAG?GCAGCTCAGTCCATGACTCAAAAGCCACTTGAAGAGGAACAAATCCAACTTTTCT

TTTCAGACATCCAACCATTACCAGCTTCTAAAGTCTTAGTCCAACTGGAAAAAGAAAATTTGTCCATTGACGACCG

AGTTTTGGTTCAAAAACTACAACTAACTGTCCGTGGCCAAGAAAAAATCGGTATTATCGG

GCCAAATGGTGTTGGGAAATCAACTCTGTTAGCCAAGTTACAGAGACTTCTGAATGATAAAAGAGAGATTTCACT

TGGTTTTATGCCACAAGATTACCACAAAAAACTGCAATTGGATTTATCCCCAATAGCCTATCTCAGTAAAACTGGG

GAAAAAGAGGAACTACAGAAAATCCAATCTCACCTAGCTAGTCTCAATTTCAGTTATCCAGAAATGCAGCATCAA

ATTCGCTCCTTATCTGGCGGACAACAGGGAAAACTCCTGCTTTTGGATTTAGTCCTGCGCAAACCAAACTTTCTCC

TGCTGGATGAACCCACACGAAACTTTTCTCCCACTTCTCAACCCCAAATCAGAAAACTCTTTGCTACCTATCCAGG

CGGTCTCATCACTGTTTCGCATGACCGTCGTTTCTTAAAAGAAGTCTGCTCGATCATCTATCGCATGACAGAACAC

GGTTTGAAGCTAGTTAATTTAGAAGATTTATAA

4179.4

ATGAAACCAAAAACATTTTACAACTTGCTTGCCGAGCAGAATCTTCCACTTTCGGACCAGCAAAAAGAACAATTT

GAACGTTATTTTGAGCTCTTGGTCGAGTGGAATGAGAAGATTAATTTGACGGCGATTACGGACAAGGAAGAAGTT

TATCTCAAACATTTTTACGATTCGATTGCACCCATTCTTCAAGGTTTGATTCCCAATGAAACTATCAAACTTCTTGA

TATCGGGGCTGGGGCAGGATTTCCTAGTCTACCAATGAAAATTCTCTATCCGGAGTTAGATGTGACCATTATTGAT

TCACTCAATAAGCGCATCAACTTCCTACAACTCTTGGCTCAAGAACTGGATTTGAACGGAGTTCATTTCTACCACG

GACGTGCCGAAGATTTTGCCCAAGACAAGAACTTCCGTGCTCAATATGATTTTGTAACAGCTCGTGCGGTTGCCCG

TATGCAGGTCCTATCTGAATTGACTATTCCCTACCTTAAGGTTGGTGGCAAACTATTAGCACTCAAGGCTAGCAAT

GCGCCTGAGGAATTATTAGAAGCTAAGAATGCCCTCAATCTCCTTTTTAGTAAGGTCGAAGACAATCTCAGccACG

CCCTACCGAATAGAGATCCGCGCTATATCACAGTGGTAGAAAAGAAAAAAGAAACACCAAATAAATATCCACGTA

AGGCTGGTATGCCAAATAAACGCCCACTTTAA

41796

ATGAGTATTAAACTAATTGCCGTTGATATCGACGGAACCCTTGTCAACAGCCAAAAGGAAATCACTCCTGAAGTTT

TTTCTGCCATCCAAGATGCCAAAGAAGCTGGTGTCAAAGTCGTGATTGCAACTGGCCGCCCTATCGCAGGCGTTGC

CAAACTTCTAGACGACTTGCAGTTGAGAGACGAGGGGGACTATGTGGTAACCTTCAACGGTGCCCTTGTCCAAGA

AACTGCTACAGGACATGAGATTATCAGCGAATCCTTGACTTATGAGGATTATCTAGATATGGAATTCCTCAGTCGC

AAGCTCGGTGTCCACATGCATGCCATTACCAAGGACGGTATCTATACTGCAAATCGCAATATCGGAAAATACACT

GTACACGAATCAACCCTCGTCAGCATGCCTATCTTCTACCGTACCCCTGAAGAAATGGCTGGCAAAGAAATTGTTA

AATGTATGTTTATCGATGAACCAGAAATTCTCGATGCTGCGATTGAAAAAATTCCAGCAGAATTTTACGAGCGCTA

CTCCATCAACAAATCTGCTCCTTTCTACCTCGAACTCCTTAAAAAGAATGTAGACAAGGGTTCAGCCATTACTCAC

TTGGCTGAAAAACTCGGATTGACCAAAGATGAAACCATGGCAATCGGTGATGAAGAAAATGACCGTGCCATGCTG

GAAGTCGTTGGAAACCCCGTTGTCATGGAAAATGGAAATCCAGAAATCAAAAAAATCGCCAAATACATCACCAAA

ACAAATGACGAATCCGGCGTTGCCCATGCCATCCGAACATGGGTACTGTAA

4179.7

ATGACTTGGATTATTCTTGGAGTTATCGCTCTTATTGTTATTTTTGTGATTGTTAGCTATAACGGTTTGGTTAAAAA

TCGTATGCAAACCAAGGAGGCTTGGAGTCAGATTGATGTTCAGTTGAAACGTCGCAATGACCTCTTGCCAAACTTG

ATTGAGACTGTAAAAGGTTATGCCAAATATGAAGGTTCTACCCTTGAAAAGGTGGCAGAACTACGTAACCAAGTG

GCGGCAGCGACTTCACCAGCAGAAGCTATGAAAGCCAGTGATGCCCTCACTCGTCAGGTTTCAGGTATTTTTGCAG

TTGCAGAAAGCTATCCAGATTTGAAAGCTAGTGCTAACTTTGTTAAATTGCAAGAGGAGTTGACAAACACAGAAA

ATAAAATTTCTTACTCTCGTCAACTCTATAACAGTGTTGTCAGCAACTACAATGTAAAATTAGAAACTTTCCCGAG

CAATATTATCGCTGGAATGTTTGGATTTAAAGCGGCAGATTTCCTTCAAACACCTGAAGAGGAAAAGTCGGTTCCT

AAAGTTGATTTTAGCGGTTTAGGTGACTAA

4179.8

ATGTTGTTTGATCAAATTGCAAGCAATAAACGAAAAACCTGGATTTTGTTGCTGGTATTTTTCCTACTCTTAGCTCT

TGTTGGTTATGCGGTTGGTTATCTCTTTATAAGATCTGGACTTGGTGGTTTGGTTATTGCACTGATTATCGGCTTTA

TCTACGCTTTGTCTATGATTTTTCAATCGACAGAGATTGTCATGTCCATGAATGGAGCGCGTGAGGTGGATGAGCA

AACGGCACCAGACCTCTACCATGTAGTGGAAGATATGGCTCTGGTCGCTCAGATTCCTATGCCCCGTGTTTTCATC

ATTGATGATCCAGCCTTAAATGCCTTTGCGACAGGTTCTAATCCTCAAAATGCGGCTGTTGCTGCGACTTCAGGTC

TACTAGCTATCATGAATCGTGAAGAACTAGAAGCTGTTATGGGACATGAAGTCAGTCATATTCGTAATTATGATAT

CCGTATTTCGACTATTGCAGTTGCCCTTGCTAGTGCTATCACCATGCTTTCTAGTATGGCAGGTCGTATGATGTGGT

GGGGTGGAGCAGGTCGCAGACGAAGTGATGATGACCGAGATGGAAATGGTCTTGAAATCATTATGCTAGTGGTTT

CCCTACTAGCTATTGTACTGGCACCTCTCGCTGCAACCTTGGTTCAGCTCGCTATTTCTCGTCAGAGGGAATTTCTG

GCAGATGCATCTAGTGTCGAGCTGACTCGCAATCCCCAGGGAATGATTAATGCCCTAGATAAGTTGGACAATAGC

AAACCTATGAGTCGCCACGTCGATGATGCTAGCAGTGCCCTTTATATCAATGATCCTAAGAAAGGTGGGGGGTTC

CAAAAACTCTTTTATACCCACCCACCTATCTCAGAACGGATTGAACGTTTAAAACAGATGTAA

4179.9

ATGAAATTAAATATTCAAGAAATTCGTAAGCAGTCTGAAGGTTTGAACTTTGAACAAACGTTAGATTTAGTTGATG

ACCTGCGTGCACGTAATCAAGAAATTTTAGATGTAAAAGATATCCTTGCAGTTGGGAAAGTACAATATGAAGACC

GTATGTATTTCTTAGATTATCAACTATCTTATACCATTGTTCTTGCTTCGAGTCGCAGTATGGAGCCAGTTGAGTTA

GTTGAATCTTATCCAGTCACGGAAGTTTTCATGGAAGGCGCAACTAACCAGCTAGATCAAGAAGTTTTAGATGATG

ACTTGGTCTTGCCCATCGAAAATGGGGAGCTTGACCTTGCTGAGAGTGTATCAGACAATATCCTGCTAAACATTCC

TATCAAGGTCTTGACGGCTGAAGAAGAAGCTGGTCAAGGATTTATCTCAGGAAATGACTGGCAAATCATGACAGA

GGAAGAATACCAAGCTCAAAAAGCAGTAAAGAAAGAAGAAAACAGTCCTTTTGCTGGCTTACAAGGACTATTTGA

CGGAGATGAATAA

4179.12

ATGGAGTTATTTATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTT

TGAAAGTGCTAGAATACGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATCTCAGGTTGCCG

TAATCCAGCCGTTTTTATGGAACGTTATTTTCAG?ATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCA

TCTTTCTCTATTTTAGATGACTGTTATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAA

GGGAAATCTTGACCTCCTGAAATTCCCGAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAA

GTCAGTTGAAAAAGTCATTCAAGGCTTGGAAAATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACAC

AGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAAACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTA

TCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGACCATCTGGTTCTAAGTGAATATGGACCTGGTGA

ACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTGGACTTTGTCGTGGTGTGATTGTAGCAGAG

GCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAAGGACGCGATGTCTTTGCTATTCCTG

GTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGCAAAATTGGTCACCAGTGGGC

AAGATGTTCTTGCGGAATTTGAATTTTAA

4181.1

ATGAAACGTCAATTAGCCTTGGTCGTCTTTAGTGGTGGTCAAGATTCAACAACCTGCCTTTTCTGGGTCATGCAAC

ACTATGAAACAGTCGAAGCTGTCACCTTTGCCTACGGCCAACGTCATCACCTCGAAATTCAAATTACTAGAGAAAT

CGCTAAGGAACAGGGCATTCGTCACCATATCCTCGATATGTCTCTGCTGGGACAAATCACTGCTCAGCCAGACTTT

GCGACGATTCATATTTCCTACATTCCTGACAAGCTCTGTGTCGAGTCAAAATCCCTCAAACTATATCTATTTAGCT

ACCGAAACCACGGAGATTTCCACGAAAACTGTATCAACACCATCGGGAAAGACTTGGTCAACTTGCTAGACCCTC

GCTATTTAGAAGTCTGGGGAAAATTCACTCCGCGCGGTGGCATTTCAATCGACCCCTACTACAACTACGGTAAGCA

AGGAACTAAGTATGAGGGCTTGGCAGAACAACGCCTCTTCCAACACGACCTTTATCCAGAGAAAATTGACAACCG

CTAA

4181.2

ATGACCGAAACGGTAGAAGATAAAGTAAGTCATTCAATTACTGGGCTTGATATCCTCAAGGGGATAGTTGCTGCG

GGAGCTGTCATAAGTGGAACCGTTGCAACTCAAACGAAGGTATTTACAAATGAGTCAGCAGTACTTGAAAAAACT

GTAGAGAAAACGGATGCTTTGGCAACAAATGATACAGTAGTTCTAGGTACGATATCTACAAGTAATTCAGCGAGT

TCAACTAGTTTGTCAGCTTCAGAGTCGGCAAGTACATCTGCATCTGAGTCAGCCTCAACCAGCGCTTCGACCTCAG

CAAGTACAAGTGCATCAGAATCAGCAAGTACATCGGCTTCGACAAGTATTTCTGCATCATCTACTGTGGTAGGTTC

ACAAACAGCTGCCGCTACAGAAGCAACTGCTAAGAAGGTCGAAGAAGATCGTAAGAAACCAGCTAGTGATTATGT

AGCATCAGTTACAAATGTCAATCTCCAATCTTATGCTAAGCGACGCAAGCGTTCAGTGGATTCCATCGAGCA?ATTG

CTGGCTTCTATAAAAAATGCTGCTGTTTTTTCTGGCAATACGATTGTAAATGGCGCCCCTGCAATTAATGCAAGTC

TAAACATTGCTAAAAGTGAGACAAAAGTTTATACAGGTGAAGGTGTAGATTCGGTATATCGTGTTCCAATTTACTA

TAAATTGAAAGTGACAAATGATGGTTCAAAATTGACCTTTACCTATACGGTTACGTATGTGAATCCTAAAACAAAT

GATCTTGGTAATATATCAAGTATGCGTCCTGGATATTCTATCTATAATTCAGGTACTTCAACACAAACAATGTTAA

CCCTTGGCAGTGATCTTGGTAAACCTTCAGGTGTAAAGAACTACATTACTGACAAAAATGGTAGACAGGTTCTATC

CTATAATACATCTACAATGACGACGCAGGGTAGTGGGTATACTTGGGGAAATGGTGCCCAAATGAATGGTTTCTTT

GCTAAGAAAGGATATGGATTAACATCATCTTGGACTGTACCAATTACTGGAACGGA

TACATCCTTTACATTTACCCCTTACGCTGCTAGAACAGATAGAATTGGAATTAACTACTTCAATGGTGGAGGAAAG

GTAGTTGAATCTAGCACGACCAGTCAGTCACTTTCACAGTCTAAGTCACTCTCAGTAAGTGCTAGTCAAAGCGCCT

CAGCTTCAGCATCAACAAGTGCGTCGGCTTCAGCATCAACCAGTGCCTCGGCTTCAGCGTCAACCAGTGCGTCAG

CTTCAGCAAGTACCAGTGCTTCAGTCTCAGCATCAACAAGTGCTTCAGCCTCAGCATCGACAAGTGCCTCGGCTTC

AGCAAGCACATCAGCATCTGAATCAGCGTCAACCAGTGCTTCGGCTTCAGCAAGTACCAGTGCTTCAGCTTCAGC

ATCAACCAGCGCCTCGGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGCGCCTCGGCCTCAGCAAG

CACCTCAGCTTCTGAATCGGCCTCAACCAGCGCCTCAGCCTCAGCATCAACGAGTGCTTCGGCTTCAGCAAGCAC

AAGCGCCTCGGGTTCAGCATCAACGAGTACGTCAGCTTCAGCGTCAACCAGTGCTTCAGCCTCAGCATCAACAAG

TGCGTCAGCCTCAGCAAGTATCTCAGCGTCTGAATCGGCATCAACGAGTGCGTCTGAGTCAGCATCAACGAGTAC

GTCAGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGTGCGTCAGCCTCAGCATCGACAAGCGCCTC

AGCTTCAGCAAGTACCAGTGCTTCAGCCTCAGCGTCGACAAGTGCGTCGGCCTCAACCAGTGCATCTGAATCGGC

ATCAACCAGTGCGTCAGCCTCAGCAAGTACTAGTGCATCGGCTTCAGCATCAACCAGTGCCTCGGCTTCAGCGTCA

ACCAGTGCGTCAG?CTTCAGCAAGTACC?AGTGCTTCAGTCTCAGCATCAACAAGTGCTTCAGCCTCAGCATCGACA

AGTGCCTCGGCTTCAGCAAGCACATCAGCATCTGAATCAGCGTCGACAAGCGCCTCAGCTTCAGCAAGTACCAGT

GCGTCAGCTTCAG?CATCAACCAGCGCCTCGGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGCGCC

TCGGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCCTCAACCAGCGCCTCAGCCTCAGCATCAACGAGTGCTTCG

GCTTCAGCAAGCACAAGCGCCTCGGGTTCAGCATCAACGAGTACGTCAGCTTCAGCGTCAACCAGTGCTTCAGCC

TCAGCATCAACAAGTGCGTCAGCCTCAGCAAGTATCTCAGCGTCTGAATCGGCATCAACGAGTGCGTCTGAGTCA

GCATCAACGAGTACGTCAGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGTGCGTCAGCCTCAGCA

TCGACAAGCGCCTCAGCTTCAGCAAGTACCAGTGCTTCAGCCTCAGCTCGACAAGTGCGTCGGCCTCAACCAGTG

CATCTGAATCGGCATCAACCAGTGCGTCAGCCTCAGCAAGTACTAGTGCATCAGCTTCAGCATCAACGAGTGCAT

CGGCTTCAGCATCAACCAGTGCCTCGGCTTCAGCGTCAACCAGTGCGTCAGCTTCAGCAAGTACCAGTGCTTCAGT

CTCAGCATCAACAAGTGCTTCAGCCTCAGCATCGACAAGTGCcTCGGCTTCAGCAAGCACATCAGCATCTGAATCA

GCGTCGACAAGCGCcTCAGCTTCAGCAAGTACCAGTGCGTCAGCCTCAGCGTCGACAAGTGCGTCAGCCTCAGCA

AGTACTAGTGCATCAGCTTCAGCATCAACGAGTGCATCGGCTTCGGCGTCAACCAGTGCATCAGAGTCAGCA?AGT

ACCAGTGCGTCAGCTTCCGCATCAACAAGTGCCTCGGCTTCAGCAAGCACCAGTGCGTCGGCTTCAGCAAGTACT

AGCGCCTCAGCCTCAGCCTCAACCAGTGCGTCAGCCTCAGCAAGTATCTCAGCGTCTGAATCGGCATCAACGAGT

GCGTCCGCTTCAGCAAGTACTAGCGCCTCAGCCTCAGCGTCAACAAGTGCATCGGCTTCAGCGTCAACGAGTGCG

TCTGAATCGGCATCAACGAGTGCGTCCGCTTCAGCAAGTACTAGCGCCTCAGCCTCAGCGTCAACAAGTGCATCG

GCTTCAGCATCAACGAGTGCGTCCGCTTCAGCAAGTACTAGCGCCTCAGCCTCAGCGTCAACAAGTGCATCGGCTT

CAGCGTCAACGAGTGCGTCTGAGTCAGCATCAACGAGTGCGTCAGCCTCAGCAAGCACATCAGCTTCTGAATCTG

CATCAACCAGTGCGTCAGCCTCAGCATCGACAAGCGCCTCAGCTTCAGCAAGTACCAGTGCGTCAGCCTCAGCGT

CGACAAGTGCGTCGGCTTCAGCAAGTACCAGTGCGTCAGCCTCAGCAAGTACCAGTGCGTCAGCCTCAGCGTCGA

CAAGTGCGTCGGCCTCAACCAGTGCATCTGAATCGGCATCAACCAGTGCGTCAGCCTCAGCAAGTACTAGTGCAT

CAGCTTCAGCATCAACGAGTGCATCGGCTTCAGCATCAACCAGTGCATCAGAGTCAGCAAGTACCAGTGCGTCAG

TTCCGCATCAACAAGTGCCTCGGCTTCAGCAAGTACTAG

4183.1

ATGGGGGTCGAAACTTGGTTTTATTCTAGCATCTGCTGGCTGGCCATCGGGCTTGGTTCCGTTTGGAAGTTTCCCT

ACATGACTGCTGCTAATGGCGGTGGAGGCTTTTTACTAATCTTTCTCATTTCCACTATTTTAATCGGTTTCCCTCTC

CTGCTGGCTGAGTTTGCCCTTGGCCGTAGTGCTGGCGTTTCCGCTATCAAAACCTTTGGAAAACTGGGCAAGAATA

ACAAGTACAACTTTATCGGTTGGATTGGCGCCTTTGCCCTCTTTATCCTCTTATCTTTTTACAGTGTTATCGGAGGA

TGGATTCTAGTCTATCTAGGTATTGAGTTTGGGAAATTGTTCCAACTTGGTGGAACGGGTGATTATGCTCAGTTAT

TTACTTCAATCATTTCAAATCCAGCCATTGCCCTAGGAGCTCAAGCGGCCTTTATCCTATTGAATATCTTCATTGTA

TCACGTGGGGTTCAAAAAGGGATTGAAAGAGCTTCG?AAAGTCATGATGCCCCTGCTCTTTATCGTCTTTGTTTTTA

TCATCGGTCGCTCTCTCAGTTTGCCAAATGCCATGGAAGGGGTTCTTTACTTCCTCAAACCAGACTTTTCAAAACT

GACTAGCACTGGTCTCCTCTATGCTCTGGGACAATCTTTCTTGCCCTCTCACTAGGGGTTACAGTCATGTTGACCT

ATGCTTCTTACTTAGACAAGAAAACCAATCTAGTCCAGTCAGGAATCTCCATCGTAGCCATGAATATCTCGATATC

CATCATGGCAGGTCTAGCCATTTTCCAAGCTCGATCCCCCTTCAATATCCAGTCTGAAGGGGGACCCAGCCTGCTC

TTTATCGTCTTGCCTCAACTCTTTGACAAGATGCCTTTTGGAACCATTTTCTACGTCCTCTTCCTCTTGCTCTTCCTT

TTTGCGACAGTCACTTTTTCTGTCGTGATGCTGGAAATCAATGTAGACAATATCACCAACCAGGATAACAGCAAAC

GTGCCAAATGGAGTGTTATTTTAGGAATTTTGACCTTTGTCTTTGGCATTCCTTCAGCCCTATCTTACGGTGTCATG

GCGGATGTTCACATTTTTGGTAAGACCTTCTTTGACGCTATGGACTTCTTGGTTTCCAATCTCCTCATGCCATTTGG

AGCTCTCTACCTTTCACTTTTTACAGGCTATATCTTTAAAAAGGCTCTTGCAATGGAGGAACTCCATCTCGATGAA

AGAGCATGGAAACAAGGACTGTTCCAAGTCTGGCTCTTCCTTCTTCGTTTCTTCGTTTCGTCATTCCAATCATCATC

ATTGTGGTCTTCATTGCCCAATTTATGTAATCAAAAAGGACTTGAGTAG

4183.5

ATGTTGAAAAAATGGCAGTTAAAAGATGTTATCTTGCTTGCTTTCTTGTCTATCTTTTTTGGTGGGGTTTTCGTTGG

TTCAGGATATGTGTATAATATTCTCAGTCTACTCTTAACACCTCTTGGTTTGCAGGCCTTTGCCAATGAAATCCTCT

TCGGTCTCTGGTGTATGGCTGCGCCCATTGCTGCCATCTTTGTTCCGAGAGTCGGAAGTGCAACGATTGGAGAAGT

GCTAGCTGCGCTTGCTGAAGTCCTTTATGGTAGCCAATTTGGTCTAGGAGCTCTTTTGTCTGGCTTTGTTCAAGGTT

TGGGAAGTGAATTTGGTTTTATCGTAACTAAGAATCGCTATGAAAGTTGGCTCTCTCTAACTGCTAATAGTATTGG

GATTACGCTTGTTAGCTTTGTCTATGAATACATTAAGTTAGGTTACTACGCCTTTTCCCTTCCGTTTGTCCTTTCCTT

GCTTGTGGTACGTTTTATTTCTGTTTATTTCTTCTGTACCATCTTGGTTCGTGCCATTGTCAAACTCTATCATCAGTT

TGCAACTGGAGGAAAAGCATAG

4183.6

ATGGTCAAAGTAGCAACCCAGACACCGATTATCAGTCTCTTCTTGCTGATTTTATCCTTGGAAACATCTTTCATTCC

TTCGATTGCTCTGACTCTTTCGGTAGTCGCATTTTGTATTCTCTTTATGCTCTATTACCGTCGATTTAAAATGTTAG

CTTGGATGATCATACTTGCCATTTTACCATCTTTTGCCAACTACTGGGCAGTTCAGTTACACGGAGATGCTTCACA

GGCAGTCATGCTTGGAACGAGGGCCTTTGTGACAGTTTGTATCGGCCTTGTCTTTGTTTCCTCTGTTTCACTAAAAG

AGCTTCTCTTGTACTTGGCTCAAAAGGGGCTATCACGCTCTTGGTCCTATGCCTTGATTGTGGTATTCAATTCTTTT

CCTCTCATTCAGCAAGAAATCAAGTCCCTCAAAGAAGCTTGCCTATTACGTGGTCAAGAACTACATTTTTGGTCGC

CCTTGATTTACAGTAAGGTTCTGATGACAGTCTTTAGGTGGCGCCATCTTTACCTGAGAGCTCTATCTGCTCACGG

ATATGACGAACATGCACAGTTGAAGAATAGCTATCGGACTTTTTATATTCCTAAAAAAACAAAATTAATCTACCTG

CTTTTCTTTTTATTGCTTCAAACCAGTCTATTTTTATAA

4183.7

ATGAGAAAGCACCAATTACAAGTTCACAAATTAACCATTTTATCTATGATGATTGCCCTTGATGTAGTCCTTACAC

CTATCTTTCGAATTGAGGGAATGGCACCGATGTCCAGTGTAGTCAATATTCTAGCAGGAATCATGATGGGACCTGT

TTATGCCTTGGCTATGGCTACAGTCACAGCCTTTATCCGTATGACGACTCAAGGGATTCCGCCTTTAGCTCTCACA

GGAGCGACTTTTGGAGCCCTTCTAGCAGGTCTCTTTTATAAGTACGGTCGAAAATTTCACTATTCTGCTCTAGGAG

AGATTTTGGGAACAGGTATTATTGGTTCCATTGTTTCCTATCCTGTTATGGTACTCTTTACAGGATCAGCTGCTAAG

CTTAGCTGGTTTATCTACACGCCTCGATTTTTCGGAGCAACCTTGATTGGTACAGCGATTTCCTTTATTGCCTTTCG

ATTTTTAATCAAGCAGGAATTCTTTAAAAAAGTGCAGGGATATTTCTTTAGTGAAAGGATAGACTGA

4183.8

ATGCAGGAATTTACAAATCCCTTTCCTATAGGCTCTAGTTCCCTCATTCACTGCATTACCAATGAGATTTCTTGTGA

GATGCTGGCAAATGGGATTTTGGCTCTGGGATGCAAACCTGTCATGGCAGATGATTCCCGTGAAGTTCTTGATTTT

ACTAAGCAAAGTCAGGCTCTCTTCATCAATTTGGGGCATTTGTCAGCTGAGAAGGAAAAAGCAATCCGCATGGCA

GCTTCGTATGCAAACCAATCTTCTCTCCCGATGGTAGTAGATGCGGTTGGCGTAACGACTTCATCCATTCGTAAGA

GCTTAGTTAAAGACCTTTTAGACTATAGACCTACGGTCCTTAAAGGAAACATGTCAGAAATTCGAAGTCTTGTTGG

ATTAAAGCACCACGGCGTTGGGGTCGATGCGAGTGCTAAAGATCAAGAAACGGAGGATTTGCTTCAAGTCTTGAA

AGACTGGTGTCAGACCTATCCTGGTATGTCTTTCTTAGTCACAGGTCCCAAGGACCTCGTCGTTTCGAAAAATCAG

GTCGCTGTACTGGGAAATGGCTGTACTGAATTAGACTGGATAACAGGGACAGGAGACTTGGTTGGAGCCTTAACA

GCTGTTTTTCTCAGCCAAGGAAAGACTGGTTTTGAAGCTTCTTGCTTAGCAGTCTCTTATCTCAATATCGCTGCTGA

GAAAATAGTTGTTCAAGGAATGGGATTGGAAGAATTTCGTTACCAAGTACTCAATCAGCTTTCGCTCCTAAGAAG

AGATGAAAATTGGCTAGATACCATCAAAGGAGAGGTTTATGAATAG

4185.3

ATGAACCATAAAATCGCAATTTTATCAGATGTTCATGGCAATGCGACGGCGCTAGAAGCAGTGATTGCAGATGCT

AAAAATCAAGGGGCCAGTGAATATTGGCTTCTGGGAGATATTTTTCTTCCTGGTCCAGGCGCAAATGACTTAGTCG

CCCTGCTAAAGGACCTTCCTATCACAGCAAGTGTTCGAGGCAATTGGGATGATCGTGTCCTTGAGGCTTTAGATGG

GCAATATGGCTTAGAAGACCCACAGGAAGTTCAGCTCTTGCGTATGACACAGTATTTGATGGAGCGA?ATGGATCC

TGCAACGATTGTCTGGCTACGAAGCTTGCCTTTGCTGGAAAAGAAAGAAATTGACGGATTGCGCTTTTCTATCTCT

CATAATTTACCTGACAAAAACTATGGTGGTGACTTGCTAGTTGAGAATGATACAGAGAAATTTGACCAACTGCTA

GATGCGGAAACGGACGTGGCAGTTTATGGTCATGTTCACAAGCAGTTGCTTCGTTATGGAAGTCAAGGGCAACAA

ATCATCAATCCAGGGTCGATTGGCATGCCCTATTTTAATTGGGAGGCGTTAAAAAATCACCGTTCCCAGTATGCCG

TGATAGAAGTTGAAGATGGGGAATTACTCAATATCCAATTTCGTAAAGTTGCTTATGATTACGAAGCTGAGTTAGA

ATTGGCCAAGTCCAAGGGGCTTCCCTTTATCGAAATGTATGAAGAACTGCGTCGTGACGATAACTATCAGGGGCA

CAATCTGGAATTATTAGCCAGCTTAATAGAAAAGCATGGGTATGTAGAGGATGTGAAGAATTTTTTTGATTTTTTG

TAA

4186.1

ATGAATGTAAATCAGATTGTACGGATTATTCCTACTTTAAAAGCTAATAATAGAAAATTAAATGAAACATTTTATA

TTGAAACCCTTGGAATGAAGGCCTTGTTAGAAGAATCGGCCTTTCTGTCACTAGGTGACCAAACGGGTCTTGAAAA

GCTGGTTTTAGAAGAAGCTCCCAGTATGCGTACTCGTAAGGTAGAGGGAAGAAAAAAACTAGCTAGATTGATTGT

CAAGGTGGAAAATCCCTTAGAAATTGAAGGAATCTTATCTAAAACAGATTCGATTCATCGATTATATAAAGGTCA

AAATGGCTACGCTTTTGAAATTTTCTCACCAGAAGATGATTTGATTTTGATTCATGCGGAAGATGACATAGCAAGT

CTAGTAGAAGTAGGAGAAAAGCCTGAATTTCAAACAGATTTGGCATCAATTTCTTTAAGTAAATTTGAGATTTCTA

TGGAATTACATCTCCCAACTGATATCGAAAGTTTCTTGGAATCATCTGAAATTGGGGCATCCCTTGATTTTATTCC

AGCTCAGGGGCAGGATTTGACTGTGGACAATACGGTTACCTGGGACTTATCTATGCTCAAGTTCTTGGTCAATGAA

TTAGACATAGCAAGTCTTCGCCAGAAGTTTGAGTCTACTGAATATTTTATTCCTAAGTCTGAAAAATTCTTCCTTG

GTAAAGATAGAAATAATGTTGAATTGTGGTTTGAAGAAGTATGA

4186.2

ATGAAGTGGACCAAGATTATTAAAAAAATAGAAGAACAAATCGAGGCAGGGATTTATCCCGGAGCCTCTTTTGCG

TATTTTAAGGACAATCAATGGACAGAGTTCTATTTAGGCCAGAGTGACCCAGAGCATGGCTTGCAGACTGAGGCA

GGACTAGTTTATGACCTAGCTAGTGTCAGCAAGGTTGTTGGGGTTGGCACAGTTTGTACCTTCTTGTGGGAAATAG

GTCAATTAGATATTGATAGACTGGTAATAGATTTTTTACCTGAGAGTGATTATCCAGACATCACTATTCGCCAGCT

CTTGACTCATGCAACAGACCTTGATCCTTTTATTCCTAATCGTGATCTTTTAACAGCCCCTGAATTAAAGGAAGCG

ATGTTTCATCTCAACAGACGAAGTCAGCCAGCCTTTCTTTATTCGGATGTCCATTTTTTGCTGTTGGGCTTTATTTT

GGAAAGAATTTTTAATCAAGATTTGGATGTGATTTTAAAGGATCAAGTCTGGAAACCTTGGGGAATGACGGAAAC

TAAGTTTGGGCCAGTTGAGCTTGCTGTTCCAACAGTTAGAGGTGTAGAGGCAGGCATAGTGCATGATCCCAAGGC

TCGTCTCCTGGGTAGACATGCTGGGAGTGCTGGTTTATTTTCG?ACTATAAAGGATTTACAAATCTTTTTAGAACAC

TATTTAGCAGATGATTTTGCAAGAGACTTAAATCAAAATTTTTCTCCTTTGGATGACAAGGAACGTTCTTTAGCAT

GGAATTTGGAAGGAGATTGGCTAGACCATACGGGCTATACAGGTACCTTTATCATGTGGAATCGTCAGAAGCAAG

AAGCCACTATTTTCCTATCGAATCGTACCTATGAAAAGGACGAGAGAGCTCAATGGATATTAGACCGCAATCAAG

TGATGAACTTGATTCGCAAAGAAGAGTAA

4187.2

ATGATGAAGAAGACTTATAATCATATTTTGGTCTGGGGAGTCATTTTCTATAGCATTTGCATTGTCTGTTTTTGCTT

TACTCCTCAAGAACAATCTACCGTGGAGTGGGAACTCCAGGTATTCAGCATCTTGGACGCCTGGTTTTTCTTTTG

ACTCCTTTCAATTCTCTCTGGAAACTGGGCGAAGTGAGTGACATTGGACAATTATGTTGGATTTTTTTACAAAATA

TCCTCAATGTCTTCTTGTTTTTTCCTCTGATTTTCCAACTCCTTTATCTATTTCCAAATTTGCGGAAAACAAAAAAG

GTCCTTCTTTTTAGTTTTCTTGTGAGTCTTGGAATCGAGTGTACGCAATTAATCTTGGACTTTTTCTTTGATTTCAAT

CGCGTCTTTGAGATTGATGATTTGTGGACCAACACTTTGGGTGGCTATCTGGCTTGGCTCCTTTATAAACGATTAC

ATAAAAACAAGGTAAGGAATTAA

4188.1

ATGAAGATTCCTCTCTTAACTTTTGCAAGGCATAAATTTGTTTATGTCTTGCTTACTTTGCTTTTTCTTGCTTTGGTT

TATCGTGATGTTTTGATGACTTATTTCTTTTTTGATATTCATGCGCCCGATCTAGCTAAATTCGATGGACAAGCAAT

TAAAAATGACTTATTAAAATCAGCATTAGATTTTCGTATTCTCCAGTTCAATCTAGGTTTTTATCAATCATTTATTA

TTCCAATCATCATTGTTTTGCTAGGTTTTCAATATATTGAGCTGAAAAATAAAGTTTTACGATTGAGTATTGGAAG

AGAAGTGAGTTATCAAGGGTTAAAAAGAAAGTTGACTTTGCAAGTTGCAAGTATCCCTTGTTTGATATATTTAGTG

ACTGTGCTGATAATTGCAATTATAACCTATTTCTTTGGGACTTTTTCTCCTCTTGGATGGAATTCTCTATTTTCTGAT

GGAAGTGGTTTACAAAGACTCCTAGATGGAGAGATAAAAAGCTATTTGTTCTTTACTTGTGTCCTACTAATCGGTA

TTTTCATCAATGCAATCTATTTTTTACAAATAGTTGATTATGTGGGGAATGTGACTCGTTCGGCAATCACCTATTTG

ATGTTTCTTTGGCTTGGTTCTATGCTGCTTTATAGTGCCTTGCCTTACTATATGGTTCCTATGACGAGTTTGATGCA

AGCTAGCTATGGGGATGTAAGTTTGATGAAACTCTTTACTCCTTATATCCTTTATATTGTCCCTTACATGGTGCTTG

AAAAATATGAAGATAATGTTTAA

4188.2

ATGAAGATAATGTTTAAGAATTTTAACAATATTTTGCTAAATAGAAAGATTGTTTTACTACTTCGTATAGTTCTGAT

GATGATTTTGATAAACCATCTATTGTCAACAGCGGTTCAAAAGCAGGATGCTGTTATCTTTTTCAAGAGAGAATTG

ATTTCAATTTTTTCCTATAATGACTATTCTGAAGCGAATTTAGAAATCCCCAAACTATTGTTAAACCTTTCGCTTTT

CATGGTAGGATGGCTCTCTGTCATTTTACTTGAAAGTGATTTGGCAGACCATTACCATCACTTGATTCGCTATCAA

TCAAGCTCCTTTTTCGATTATACAAGGAAACGATTGGTTGTCATTTCTAAATTTTTTACTCAAGATTTGTTTGTCTG

GTTTCTTGGTTTACTTCCTCTAGGAATTCATTTCAAAACAGTCGCACTTTCTTTTTACTTGCTCAGTTAATGATGTT

GTACTTACTACTGTCTTATCTGATAGCACTGATTAGTGCGGGCGCTGGTTTTTCCTTTTTTCTCTATTTTTTAGCATT

TGTGGGACAAGAATGGATGATGGATCATATTGTAACAGTGTATTTAGTACTCTTAAGTTTATTAGTTATGTTGATT

GTTAGTCGCTTGGAAGAGAAATTTAAGAAAGGATAA

4188.5

ATGGGCAAAGGAGAGATGGGCAAAGGAGTTATTGGCTTGGAGTTCGACTCAGAAGTATTGGTCAACAAGGCTCCA

ACCCTTCAATTGGCAAATGGTAAAACAGCGACTTTCCTAACCCAGTATGATAGCAAGACCTTGTTGTTTGCAGTAG

ATAAGGAAGATATCGGACAGGAAATTATTGGTATAGCTAAAGGAAGCATCGAAAGTATGCATAATCTTCCTGTAA

ATCTAGCAGGTGCCAGAGTTCCTGGCGGAGTAAATGGTAGCAAAGCAGCGGTGCATGAAGTTCCAGAATTTACAG

GGGGAGTTAATGGTACAGAGCCAGCTGTTCATGAAATCGCAGAGTATAAGGGATCTGATTCGCTTGTAACTCTTAC

TACAAAAAAAGATTATACTTACAAAGCTCCTCTTGCTCAGCAGGCACTTCCTGAAACAGGAAACAAGGAGAGTGA

CCTCCTAGCTTCACTAGGACTAACAGCTTTCTTCCTTGGTCTGTTTACGCTAGGGAAAAAGAGAGAACAATAA

4188.10

ATGTTTAAAGTTTTACAAAAAGTTGGAAAAGCTTTTATGTTACCTATAGCTATACTTCCTGCAGCAGGTCTACTTTT

GGGGATTGGTGGTGCACTTTCAAACCCAACCACGATAGCAACTTATCCAATACTAGACAATAGTATTTTTCAATCA

ATATTCCAAGTAATGAGCTCTGCAGGAGAGGTTGTATTCAGTAATTTGTCACTACTTCTCTGTGTGGGATTATGTA

TTGGCTTAGCGAAACGAGATAAAGGAACCGCTGCGTTAGCAGGAGTAACTGGTTACTTAGTTATGACTGCAACGA

TCAAAGCTTTGGTAAAACTTTTTATGGCAGAAGGATCTGCAATTGATACTGGAGTTATTGGAGCATTAGTTGTCGG

AATAGTTGCCGTATATTTGCACAACCGATATAACAATATTCAATTACCTTCCGCTTTTAGGATTCTTTGGAGGTTCA

CGCTTCGTTCCTATTGTTACATCGTTCTCTTCTATCTTGATTGGCTTTGTCTTCTTTGTTATTTGGCCACCTTTCCAA

CAACTTCTTGTTTCTACAGGTGGATATATTTCTCAGGCGGGTCCAATTGGAACTTTTCTATATGGATTTTTAATGAG

ACTTTCTGGAGCAGTAGGCTTACATCATATAATTTACCCTATGTTTTGGTATACTGAACTTGGTGGTGTTGAAACTG

TTGCAGGACAAACAGTGGTTGGAGCTCAAAAAATATTTTTTGCTCAATTAGCCGATTTGGCCCATTCTGGATTATT

TACAGAAGGAACAAGGTTTTTTGCAGGTCGTTTCTCAACAATGATGTTCGGTTTACCGGCTGCCTGTTTAGCGATG

TACCATAGTGTTCCTAAAAATCGTCGTAAAAAATACGCGGGTTTGTTTTTTGGAGTTGCTTTAACATCTTTTATTAC

CGGTATTACAGAACCAATTGAATTTATGTTTCTATTCGTCAGTCCGGTTCTATATGTTGTTCACGCATTCCTTGATG

GTGTTAGCTTCTTTATTGCAGACGTCTTAAATATTTCAATAGGAAACACATTTTCAGGAGGTGTAATCGATTTCACT

TTATTTGGAATTTTGCAGGGGAACGCTAAGACGAATTGGGTTCTTCAGATTCCATTTGGACTTATTTGGAGTGTTTT

GTATTATATTATTTTTAGATGGTTCATTACTCAATTCAACGTTCTAACGCCAGGGCGAGGAGAAGAAGTAGATTCT

AAAGAAATTTCTGAATCCGCAGATTCAACTTCAAATACTGCAGATTATTTAAAACAGGATAGCCTACAAATTATCA

GAGCCTTGGGTGGATCAAATAATATAGAAGATGTAGATGCTTGTGTGACACGTTTACGTGTAGCTGTAAAAGAAG

TTAATCAAGTTGATAAAGCACTTTTAAAACAAATTGGTGCAGTTGATGTCTTAGAAGTGAAGGGTGGCATTCAAGC

AATCTATGGAGCAAAAGCAATCTTATATAAAAATAGTATTAATGAAATTTTAGGTGTAGATGATTAA

4188.11

ATGAAATTTAGAAAATTAGCTTGTACAGTACTTGCGGGTGCTGCGGTTCTTGGTCTTGCTGCTTGTGGCAATTCTG

GCGGAAGTAAAGATGCTGCCAAATCAGGTGGTGACGGTGCCAAAACAGAAATCACTTGGTGGGCATTCCCAGTAT

TTACCCAAGAAAAAACTGGTGACGGTGTTGGAACTTATGAAAAATCAATCATCGAAGCGTTTGAAAAAGCAAACC

CAGATATAAAAGTGAAATTGGAAACCATCGACTTCAAGTCAGGTCCTGAAAAAATCACAACAGCCATCGAAGCAG

GAACAGCTCCAGACGTACTCTTTGATGCACCAGGACGTATCATCCAATACGGTAAAAACGGTAAATTGGCTGAGT

TGAATGACCTCTTCACAGATGAATTTGTTAAAGATGTCAACAATGAAAACATCGTACAAGCAAGTAAAGCTGGAG

ACAAGGCTTATATGTATCCGATTAGTTCTGCCCCATTCTACATGGCAATGAACAAGAAAATGTTAGAAGATGCTGG

AGTAGCAAACCTTGTAAAAGAAGGTTGGACAACTGATGATTTTGAAAAAGTATTGAAAGCACTTAAAGACAAGGG

TTACACACCAGGTTCATTGTTCAGTTCTGGTCAAGGGGGAGACCAAGGAACACGTGCCTTTATCTCTAACCTTTAT

AGCGGTTCTGTAACAGATGAAAAAGTTAGCAAATATACAACTGATGATCCTAAATTCGTCAAAGGTCTTGAAAAA

GCAACTAGCTGGATTAAAGACAATTTGATCAATAATGGTTCACAATTTGACGGTGGGGCAGATATCCAAAACTTT

GCCAACGGTCAAACATCTTACACAATCCTTTGGGCACCAGCTCAAAATGGTATCCAAGCTAAACTTTTAGAAGCA

AGTAAGGTAGAAGTGGTAGAAGTACCATTCCCATCAGACGAAGGTAAGCCAGCTCTTGAGTACCTTGTAAACGGG

TTTGCAGTATTCAACAATAAAGACGACAAGAAAGTCGCTGCATCTAAGAAATTCATCCAGTTTATCGCAGATGAC

AAGGAGTGGGGACCTAAAGACGTAGTTCGTACAGGTGCTTTCCCAGTCCGTACTTCATTTGGAAAACTTTATGAAG

ACAAACGCATGGAAACAATCAGCGGCTGGACTCAATACTACTCACCATACTACAACACTATTGATGGATTTGCTG

AAATGAGAACACTTTGGTTCCCAATGTTGCAATCTGTATCAAATGGTGACGAAAAACCAGCAGATGCTTTGAAAG

CCTTCACTGAAAAAGCGAACGAAACAATCAAAAAAGCTATGAAACAATAG

4188.12

ATGCAATCTACAGAAAAAAAACCATTAACAGCCTTTACTGTTATTTCAACAATCATTTTGCTCTTGTTGACTGTGC

TGTTCATCTTTCCATTCTACTGGATTTTGACAGGGGCATTCAAATCACAACCTGATACAATTGTTATTCCTCCTCAG

TGGTTCCCTAAAATGCCAACCATGGAAAACTTCCAACAACTCATGGTGCAGAACCCTGCCTTGCAATGGATGTGG

AACTCAGTATTTATCTCATTGGTAACCATGTTCTTAGTTTGTGCAACCTCATCTCTAGCAGGTTATGTATTGGCTAA

AAAACGTTTCTATGGTCAACGCATTCTATTTGCTATCTTTATCGCTGCTATGGCGCTTCCAAAACAAGTTGTCCTTG

TACCATTGGTACGTATCGTCAACTTCATGGGAATCCATGATACTCTCTGGGCAGTTATCTTGCCTTTGATTGGATG

GCCATTCGGTGTCTTCCTCATGAAACAGTTCAGTGAAAATATCCCTACAGAGTTGCTTGAATCAGCTAAAATCGAC

GGTTGTGGTGAGATTCGTACCTTCTGGAGTGTAGCCTTCCCGATTGTGAAACCAGGGTTTGCAGCCCTTGCAATCT

TTACCTTCATCAATACTTGGAATGACTACTTCATGCAATTGGTAATGTTGACTTCACGTAACAATTTGACCATCTCA

CTTGGGGTTGCGACCATGCAGGCTGAAATGGCAACCAACTATGGTTTGATTATGGCAGGAGCTGCCCTTGCTGCTG

TTCCAATCGTCACAGTCTTCCTAGTCTTCCAAAAATCCTTCACACAGGGTATTACTATGGGAGCGGTCAAAGGATA

A

4191.1

ATGAAAAAAACTTTTTTCTTACTGGTGTTAGGCTTGTTTTGCCTTCTTCCACTCTCTGTTTTTGCCATTGATTTCAAG

ATAAACTCTTATCAAGGGGATTTGTATATTCATGCAGACAATACGGCAGAGTTTAGACAGAAGATAGTTTACCAGT

TTGAGGAGGACTTTAAGGGCCAAATCGTGGGACTTGGACGTGCTGGTAAGATGCCTAGCGGGTTTGACATTGACC

CTCATCCAAAGATTCAGGCCGCGAAAAACGGTGCAGAACTAGCAGATGTGACTAGCGAAGTAACAGAAGAAGCG

GATGGTTATACTGTGAGAGTCTATAATCCAGGTCAGGAGGGCGACATAGTTGAAGTTGACCTCGTCTGGAACTTA

AAAAATTTACTTTTCCTTTATGATGATATCGCTGAATTAAATTGGCAACCTCTGACAGATAGTTCAGAGTCTATTG

AAAAGTTTGAATTTCATGTAAGGGGAGACAAGGGGGCTGAAAAACTCTTTTTCCATACAGGGAAACTTTTTAGAG

AGGGAACGATTGAAAAGAGTAACCTTGATTATACTATCCGTTTAGACAATCTTCCGGCTAAGCGTGGAGTTGAGTT

GCATGCCTATTGGCCTCGGACCGATTTTGCTAGCGCTAGGGATCAGGGATTGAAAGGGAATCGTTTAGAAGAGTTT

AATAAGATAGAAGACTCGATTGTTAGAGAAAAAGATCAGAGTAAACAACTCGTTACTTGGGTCCTCCCTTCGATC

CTTTCCATCTCCTTGTTATTGAGTGTCTGCTTCTATTTTATTTATAGAAGAAAGACCACTCCTTCAGTCAAATATGC

CAAAAATCATCGTCTCTATGAACCACCAATGGAATTAGAGCCTATGGTTTTATCAGAAGCAGTCTACTCGACCTCC

TTGGAGGAAGTGAGTCCCTTGGTCAAGGGAGCTGGAAAATTCACCTTTGATCAACTTATTCAAGCTACCTTGCTAG

ATGTGATAGACCGTGGGAATGTCTCTATCATTTCAGAAGGAGATGCAGTTGGTTTGAGGCTAGTAAAAGAAGATG

GTTTGTCAAGCTTTGAGAAAGACTGCCTAAATCTAGCTTTTTCAGGTAAAAAAGAAGAAACTCTTTCCAATTTGTT

TGCGGATTACAAGGTATCTGATAGTCTTTATCGTAGAGCCAAAGTTTCTGATGAAAAACGGATTCAAGCAAGAGG

GCTTCAACTCAAATCTTTTTTGAAGAGGTATTGAACCAGATGCAAGAAGGAGTGAGAAAACGAGTTTCCTTCTGG

GGGCTCCCAGATTATTATCGTCCTTTAACTGGTGGGGAAAAGGCCTTGCAAGTGGGTATGGGTGCCTTGACTATCC

TGCCCCTATTTATCGGATTTGGTTTGTTCTTGTACAGTTTAGACGTTCATGGCTATCTTTACCTCCCTTTGCCAATA

CTTGGTTTTCTAGGGTTAGTTTTGTCTGTTTTCTATTATTGGAAGCTTCGACTAGATAATCGTGATGGTGTTCTAAA

TGAAGCGGGAGCTGAGGTCTACTATCTCTGGACCAGTTTTGAAAATATGTTGCGTGAGATTGCACGATTGGATCAG

GCTGAACTGGAAAGTATTGTGGTCTGGAATCGCCTCTTGGTCTATGCGACCTTATTTGGCTATGCGGACAAGGTTA

GTCATTTGATGAAGGTTCATCAGATTCAAGTGGAAAATCCAGATATCAATCTCTATGTAGCTTATGGCTGGCACAG

TACGTTTTATCATTCAACAGCACAAATGAGCCATTATGCTAGTGTCGCAAATACAGCAAGCACCTACTCTGTATCT

TCTGGAAGTGGAAGTTCTGGTGGTGGCTTCTCTGGAGGCGGAGGTGGCGGCAGTATCGGTGCCTTTTAA

4191.2

ATGAAAAAAGTAAGAAAGATATTTCAGAAGGCAGTTGCAGGACTGTGCTGTATATCTCAGTTGACAGCTTTTTCTT

CGATAGTTGCTTTAGCAGAAACGCCTGAAACCAGTCCAGCGATAGGAAAAGTAGTGATTAAGGAGACAGGCGAAG

GAGGAGCGCTTCTAGGAGATGCCGTCTTTGAGTTGAAAAACAATACGGATGGCACAACTGTTTCGCAAAGGACAG

AGGCGCAAACAGGAGAAGCGATATTTTCAAACATAAAACCTGGGACATACACCTTGACAGAAGCCCAACCTCCAG

TTGGTTATAAACCCTCTACTAAACAATGGACTGTTGAAGTTGAGAAGAATGGTCGGACGACTGTCCAAGGTGAAC

AGGTAGAAAATCGAGAAGAGGCTCTATCTGACCAGTATCCACAAACAGGGACTTATCCAGATGTTCAAACACCTT

ATCAGATTATTAAGGTAGATGGTTCGGAAAAAAACGGACAGCACAAGGCGTTGAATCCGAATCCATATGAACGTG

TGATTCCAGAAGGTACACTTTCAAAGAGAATTTATCAAGTGAATAATTTGGATGATAACCAATATGGAATCGAATT

GACGGTTAGTGGGAAAACAGTGTATGAACAAAAAGATAAGTCTGTGCCGCTGGATGTCGTTATCTTGCTCGATAA

CTCAAATAGTATGAGTAACATTCGAAACAAGAATGCTCGACGTGCGGAAAGAGCTGGTGAGGCGACACGTTCTCT

TATTGATAAAATTACATCTGATTCAGAAAATAGGGTAGCGCTTGTGACTTATGCTTCCACTATCTTTGATGGGACC

GAGTTTACAGTAGAAAAAGGGGTAGCAGATAAAAACGGAAAGCGATTGAATGATTCTCTTTTTTGGAATTATGAT

CAGACGAGTTTTACAACCAATACCAAAGATTATAGTTATTTAAAGCTGACTAATGATAAGAATGACATTGTAGAAT

TAAAAAATAAGGTACCTACCGAGGCAGAAGACCATGATGGAAATAGATTGATGTACCAATTCGGTGCCACTTTTA

CTCAGAAAGCTTTGATGAAGGCAGATGAGATTTTGACACAACAAGCGAGACAAAATAGTCAAAAAGTCATTTTCC

ATATTACGGATGGTGTCCCAACTATGTCGTATCCGATTAATTTTAATCATGCTACGTTTGCTCCATCATATCAAAAT

CAACTAAATGCATTTTTTAGTAAATCTCCTAATAAAGATGGAATACTATTAAGTGATTTTATTACGCAAGCAACTA

GTGGAGAACATACAATTGTACGCGGAGATGGGCAAAGTTACCAGATGTTTACAGATAAGACAGTTTATGAAAAAG

GTGCTCCTGCAGCTTTCCCAGTTAAACCTGAAAAATATTCTGAAATGAAGGCGGCTGGTTATGCAGTTATAGGCGA

TCCAATTAATGGTGGATATATTTGGCTTAATTGGAGAGAGAGTATTCTGGCTTATCCGTTTAATTCTAATACTGCTA

AAATTACCAATCATGGTGACCCTACAAGATGGTACTATAACGGGAATATTGCTCCTGATGGGTATGATGTCTTTAC

GGTAGGTATTGGTATTAACGGAGATCCTGGTACGGATGAAGCAACGGCTACTAGTTTTATGCAAAGTATTTCTAGT

AAACCTGAAAACTATACCAATGTTACTGACACGACAAAAATATTGGAACAGTTGAATCGTTATTTCCACACCATC

GTAACTGAAAAGAAATCAATTGAGAATGGTACGATTACAGATCCGATGGGTGAGTTAATTGATTTGCAATTGGGC

ACAGATGGAAGATTTGATCCAGCAGATTACACTTTAACTGCAAACGATGGTAGTCGCTTGGAGAATGGACAAGCT

GTAGGTGGTCCACAAAATGATGGTGGTTTGTTAAAAAATGCAAAAGTGCTCTATGATACGACTGAGAAAAGGATT

CGTGTAACAGGTCTGTACCTTGGAACGGATGAAAAAGTTACGTTGACCTACAATGTTCGTTTGAATGATGAGTTTG

TAAGCAATAAATTTTATGATACCAATGGTCGAACAACCTTACATCCTAAGGAAGTAGAACAGAACACAGTGCGCG

ACTTCCCGATTCCTAAGATTCGTGATGTGCGGAAGTATCCAGAAATCACAATTTCAAAAGAGAAAAAACTTGGTG

ACATTGAGTTTATTAAGGTCAATAAAAATGATAAAAAACCACTGAGAGGTGCGGTCTTTAGTCTTCAAAAACAAC

ATCCGGATTATCCAGATATTTATGGAGCTATTGATCAAAATGGCACTTATCAAAATGTGAGAACAGGTGAAGATG

GTAAGTTGACCTTTAAAAATCTGTCAGATGGGAAATATCGATTATTTGAAAATTCTGAACCAGCTGGTTATAAACC

CGTTCAAAATAAGCCTATCGTTGCCTTCCAAATAGTAAATGGAGAAGTCAGAGATGTGACTTCAATCGTTCCACAA

GATATACCAGCGGGTTACGAGTTTACGAATGATAAGCACTATATTACCAATGAACCTATTCCTCCAAAGAGAGAA

TATCCTCGAACTGGTGGTATCGGAATGTTGCCATTCTATCTGATAGGTTGCATGATGATGGGAGGAGTTCTATTAT

ACACACGGAAACATCCGTAA

4191.3

ATGAAATCAATCAACAAATTTTTAACAATGCTTGCTGCCTTATTACTGACAGCGAGTAGCCTGTTTTCAGCTGCAA

CAGTTTTTGCGGCTGGGACGACAACAACATCTGTTACCGTTCATAAACTATTGGCAACAGATGGGGATATGGATA

AAATTGCAAATGAGTTAGAAACAGGTAACTATGCTGGTAATAAAGTGGGTGTTCTACCTGCAAATGCAAAAGAAA

TTGCCGGTGTTATGTTCGTTTGGACAAATACTAATAATGAAATTATTGATGAAAATGGCCAAACTCTAGGAGTGAA

TATTGATCCACAAACATTTAAACTCTCAGGGGCAATGCCGGCAACTGCAATGAAAAAATTAACAGAAGCTGAAGG

AGCTAAATTTAACACGGCAAATTTACCAGCTGCTAAGTATAAAATTTATGAAATTCACAGTTTATCAACTTATGTC

GGTGAAGATGGAGCAACCTTAACAGGTTCTAAAGCAGTTCCAATTGAAATTGAATTACCATTGAACGATGTTGTG

GATGCGCATGTGTATCCAAAAAATACAGAAGCAAAGCCAAAAATTGATAAAGATTTCAAAGGTAAAGCAAATCCA

GATACACCACGTGTAGATAAAGATACACCTGTGAACCACCAAGTTGGAGATGTTGTAGAGTACGAAATTGTTACA

AAAATTCCAGCACTTGCTAATTATGCAACAGCAAACTGGAGCGATAGAATGACTGAAGGTTTGGCATTCAACAAA

GGTACAGTGAAAGTAACTGTTGATGATGTTGCACTTGAAGCAGGTGATTATGCTCTAACAGAAGTAGCAACTGGTT

TTGATTTGAAATTAACAGATGCTGGTTTAGCTAAAGTGAATGACCAAAACGCTGAAAAAACTGTGAAAATCACTT

ATTCGGCAACATTGAATGACAAAGCAATTGTAGAAGTACCAGAATCTAATGATGTAACATTTAACTATGGTAATA

ATCCAGATCACGGGAATACTCCAAAGCCGAATAAGCCAAATGAAAACGGCGATTTGACATTGACCAAGACATGGG

TTGATGCTACAGGTGCACCAATTCCGGCTGGAGCTGAAGCAACGTTCGATTTGGTTAATGCTCAGACTGGTAAAGT

TGTACAAACTGTAACTTTGACAACAGACAAAAATACAGTTACTGTTAACGGATTGGATAAAAATACAGAATATAA

ATTCGTTGAACGTAGTATAAAAGGGTATTCAGCAGATTATCAAGAAATCACTACAGCTGGAGAAATTGCTGTCAA

GAACTGGAAAGACGAAAATCCAAAACCACTTGATCCAACAGAGCCAAAAGTTGTTACATATGGTAAAAAGTTTGT

CAAAGTTAATGATAAAGATAATCGTTTAGCTGGGGCAGAATTTGTAATTGCAAATGCTGATAATGCTGGTCAATAT

TTAGCACGTAAAGCAGATAAAGTGAGTCAAGAAGAGAAGCAGTTGGTTGTTACAACAAAGGATGCTTTAGATAGA

GCAGTTGCTGCTTATAACGCTCTTACTGCACAACAACAAACTCAGCAAGAAAAAGAGAAAGTTGACAAAGCTCAA

GCTGCTTATAATGCTGCTGTGATTGCTGCCAACAATGCATTTGAATGGGTGGCAGATAAGGACAATGAAAATGTTG

TGAAATTAGTTTCTGATGCACAAGGTCGCTTTGAAATTACAGGCCTTCTTGCAGGTACATATTACTTAGAAGAAAC

AAAACAGCCTGCTGGTTATGCATTACTAACTAGCCGTCAGAAATTTGAAGTCACTGCAACTTCTTATTCAGCGACT

GGACAAGGCATTGAGTATACTGCTGGTTCAGGTAAAGATGACGCTACAAAAGTAGTCAACAAAAAAATCACTATC

CCACAAACGGGTGGTATTGGTACAATTATCTTTGCTGTAGCGGGGGCTGCGATTATGGGTATTGCAGTGTACGCAT

ATGTTAAAAACAACAAAGATGAGGATCAACTTGCTTAA

4191.4

ATGACAATGCAGAAAATGCAGAAAATGATTAGTCGTATCTTCTTTGTTATGGCTCTGTGTTTTTCTCTTGTATGGGG

TGCACATGCAGTCCAAGCGCAAGAAGATCACACGTTGGTCTTGCAATTGGAGAACTATCAGGAGGTGGTTAGTCA

ATTGCCATCTCGTGATGGTCATCGGTTGCAAGTATGGAAGTTGGATGATTCGTATTCCTATGATGATCGGGTGCAA

ATTGTAAGAGACTTGCATTCGTGGGATGAGAATAAACTTTCTTCTTTCAAAAAGACTTCGTTTGAGATGACCTTCC

TTGAGAATCAGATTGAAGTATCTCATATTCCAAATGGTCTTTACTATGTTCGCTCTATTATCCAGACGGATGCGGT

TTCTTATCCAGCTGAATTTCTTTTTGAAATGACAGATCAAACGGTAGAGCCTTTGGTCATTGTAGCGAAAAAAACA

GATACAATGACAACAAAGGTGAAGCTGATAAAGGTGGATCAAGACCACAATCGCTTGGAGGGTGTCGGCTTTAAA

TTGGTATCAGTAGCAAGAGATGTTTCTGAAAAAGAGGTTCCCTTGATTGGAGAATACCGTTACAGTTCTTCTGGTC

AAGTAGGGAGAACTCTCTATACTGATAAAAATGGAGAGATTTTTGTGACAAATCTTCCTCTTGGGAACTATCGTTT

CAAGGAGGTGGAGCCACTGGCAGGCTATGCTGTTACGACGCTGGATACGGATGTCCAGCTGGTAGATCATCAGCT

GGTGACGATTACGGTTGTCAATCAGAAATTACCACGTGGCAATGTTGACTTTATGAAGGTGGATGGTCGGACCAA

TACCTCTCTTCAAGGGGCAATGTTCAAAGTCATGAAAGAAGAAAGCGGACACTATACTCCTGTTCTTCAAAATGGT

AAGGAAGTAGTTGTAACATCAGGGAAAGATGGTCGTTTCCGAGTGGAAGGTCTAGAGTATGGGACATACTATTTA

TGGGAGCTCCAAGCTCCAACTGGTTATGTTCAATTAACATCGCCTGTTTCCTTTACAATCGGGAAAGATACTCGTA

AGGAACTGGTAACAGTGGTTAAAAATAACAAGCGACCACGGATTGATGTGCCAGATACAGGGGAAGAAACCCTTG

TATATCTTGATGCTTGTTGCCATTTTGTTGTTTGGTAG

4191.5

ATGAGCCACATATACTTATCTATTTTCACAAGTCTCTTGCTGATGCTAGGACTTGTCAATGTTGCTCAAGCCGATG

AATATTTACGCATCGGTATGGAAGCAGCATATGCTCCCTTTAACTGGACCCAGGATGATGATAGCAACGGAGCTG

TCAAAATCGATGGGACCAATCAGTATGCCAACGGATACGATGTTCAAATCGCCAAGAAAATCGCTAAGGACTTAG

GTAAAGAACCTTTGGTTGTTAAAACCAAGTGGGAAGGTCTAGTCCCTGCCCTTACTTCTGGTAAGATTGACATGAT

TATCGCAGGTATGAGTCCAACTGCAGAACGCAAACAAGAAATTGCCTTTTCGAGCAGTTACTATACTAGCGAACC

AGTTTTGCTTGTCAAAAAAGATTCTGCCTACGCAAGTGCTAAATCTTTGGATGACTTTAACGGTGCAAAAATCACT

TCTCAACAAGGGGTCTACCTTTATAACTTGATTGCACAAATCCCAGGTGCTAAAAAAGAAACAGCCATGGGAGAC

TTCGCTCAAATGCGACAAGCTCTTGAGGCTGGTGTCATTGATGCTTATGTTTCTGAACGTCCAGAAGCACTGACTG

CTGAAGCTGCGAACTCTAAGTTCAAGATGATTCAAGTAGAACCTGGTTTCAAAACTGGGGAAGAAGATACAGCTA

TCGCTATCGGGCTTCGTAAAAATGACAATCGTATTAGCCAAATCAATGCCAGCATTGAAACCATTTCAAAAGATG

ACCAAGTTGCCTTGATGGATCGTATGATCAAGGAACAACCTGCCGAAGCTACAACAACTGAAGAGACTAGCAGTA

GTTTCTTTAGCCAAGTTGCTAAAATTCTTTCTGAAAACTGGCAACAACTCTTGCGTGGTGCTGGTATCACTCTTTTA

ATCTCTATCGTCGGAACCATCATAGGTCTCATTATTGGACTTGCCATTGGTGTCTTCCGTACTGCTCCTCTCTCTGA

AAACAAAGTCATTTACGGCCTACAAAAACTAGTCGGCTGGGTTCTCAATGTCTACATTGAAATTTTCCGTGGTACG

CCAATGATTGTTCAATCGATGGTTATCTACTATGGAACTGCCCAAGCTTTCGGGATCAACC

TTGACCGTACACTGGCTGCTATCTTCATCGTTTCAATCAATACCGGTGCCTACATGACTGAAATCGTCCGTGGTGG

TATCCTAGCAGTTGACAAGGGACAATTTGAAGCTGCGACTGCTCTTGGTATGACCCATAACCAGACCATGCGTAA

GATTGTCCTACCTCAGGTAGTCCGTAACATCCTACCTGCAACTGGTAATGAATTTGTCATCAATATCAAAGATACA

TCTGTATTGAACGTTATCTCTGTTGTCGAACTTTATTTCTCAGGAAATACCGTGGCAACACAAACCTATCAATACTT

CCAGACATTTACAATCATCG?CCGTGATTTACTTTGTCCTCACCTTCACCGTAACACGTATCCTACGCTTTATCGAGC

GCAGAATGGACATGGATACCTACACTACAGGTGCTAACCAAATGCAAACGGAGGATTTGAAATAA

4191.6

ATGACACAAGCAATCCTTGAAATTAAACACCTCAAAAAATCCTATGGACAAAACGAAGTGCTAAAAGACATTTCA

CTCACTGTCCACAAGGGAGAGGTCATCTCTATCATCGGAAGCTCTGGAAGCGGAAAATCGACCTTCCTACGCTCC

ATTAACCTACTTGAAACACCAACTGATGGACAAATCCTTTATCATGGACAAAACGTCCTCGAAAAAGGCTATGAC

CTCACGCAATACCGTGAAAAGTTGGGGATGGTTTTCCAATCCTTTAACCTCTTTGAAAATCTCAATGTTCTTGAAA

ACACAATCGTCGCTCAGACAACTGTCCTAAAACGCGAACGCACAGAAGCTGAAAAGATTGCCAAAGAAAACCTG

GAAAAGGTCGGCATGGGAGAACGCTACTGGCAAGCCAAACCAAAACAACTCTCAGGTGGTCAAAAACAACGTGT

GGCCATCGCTCGTGCCCTCTCCATGAATCCGGACGCTATTCTCTTTGATGAACCAACATCAGCTCTCGATCCAGAA

ATGGTTGGAGAAGTCCTCAAAATCATGCAGGACCTGGCTCAGGAAGGCTTG?ACCATGATTGTCGTAACCCATGAA

ATGGAATTTGCCCGTGATGTCTCTCACCGTGTTATCTTTATGGATAAGGGCGTGATCGCTGAAGAAGGTAAACCAG

AAGACCTCTTCACCAATCCTAAAGAAGACCGAACAAAAGAGTTCCTTCAACGCTATCTCAAATAA

4192.3

ATGAAAAAGTATCAACTTCTATTCAAAATAAGTGCAGTCTTCTCTTACTTATTTTTCGTATTTAGTCTTTCTCAGCT

GACGCTTATCGTCCAAAACTATTGGCAATTTTCTTCTCAGATAGGCAATTTATTCTGGATTCAAAATATCTTGAGTT

TACTTTTTATTGGAGTCATGATTGTGGTTCTTGTTAAGACAGGCCATGGTTATCTCTTCCGCATTCCAAGAAAAAA

ATGGCTTTGGTATTCGATTTTGACAGTATTAGTGCTAGTGTTCCAGATCTCTTTTAACGTTCAGACAGCTAAACATG

TTCAGTCAACTGCGGAAGGTTGGGCTGTATTGATTGGTTATAGTGGGACTAACTTTGCAGAGCTAGGTATTTATAT

AGCCCTGTTCTTTCTGGTTCCACTGATGGAAGAATTGATTTATAGAGGATTACTGCAACATGCTTTCTTTAAGCATT

CGCGATTTGGTCTTGATTTGCTTCTTCCTTCTATTTTATTTGCTCTCCCTCATTTTTCAAGCCTGCCTAGTCTGTTAG

ATATCTTCGTCTTTGCAACAGTTGGAATCATCTTTGCTGGTTTGACCCGCTATACCAAGAGCATTTATCCATCCTAT

GCGGTGCATGTGATCAATAATATTGTAGCGACCTTCCCGTTTTTGCTCACTTTTCTACATAGGGTCTTGGGGTAA

4193.1

ATGAACAAGAAACAATGGCTAGGTCTTGGCCTAGTTGCAGTGGCAGCAGTTGGACTTGCTGCATGTGGTAACCGC

TCTTCTCGTAACGCAGCTTCATCTTCTGATGTGAAGACAAAAGCAGCAATCGTCACTGATACTGGTGGTGTTGATG

ACAAATCATTCAACCAATCAGCTTGGGAAGGTTTGCAGGCTTGGGGTAAAGAACACAATCTTTCAAAAGATAACG

GTTTCACTTACTTCCAATCAACAAGTGAAGCTGACTACGCTAACAACTTGCAACAAGCGGCTGGAAGTTACAACCT

AATCTTCGGTGTTGGTTTTGCCCTTAATAATGCAGTTAAAGATGCAGCAAAAGAACACACTGACTTGAACTATGTC

TTGATTGATGATGTGATTAAAGACCAAAAGAATGTTGCGAGCGTAACTTTCGCTGATAATGAGTCAGGTTACcTTG

CAGGTGTGGCTGCAGCAAAAACAACTAAGACAAAACAAGTTGGTTTTGTAGGTGGTATCGAATCTGAAGTTATCT

CTCGTTTTGAAGCAGGATTCAAGGCTGGTGTTGCGTCAGTAGACCCATCTATCAAAGTCCAAGTTGACTACGCTGG

TTCATTTGGTGATGCGGCTAAAGGTAAAACAATTGCAGCCGCACAATACGCAGCCGGTGCAGATATTGTTTACCA

AGTAGCTGGTGGTACAGGTGCAGGTGTCTTTGCAGAGGCAAAATCTCTCAACGAAAGCCGTCCTGAAAATGAAAA

AGTTTGGGTTATCGGTGTTGATCGTGACCAAGAAGCAGAAGGTAAATACACTTCTAAAGATGGCAAAGAATCAAA

CTTTGTTCTTGTATCTACTTTGAAACAAGTTGGTACAACTGTAAAAGATATTTCTAACAAGGCAGAAAGAGGAGAA

TTCCCTGGCGGTCAAGTGATCGTTTACTCATTGAAGGATAAAGGGGTTGACTTGGCAGTAACAAACCTTTCAGAAG

AAGGTAAAAAAGCTGTCGAAGATGCAAAAGCTAAAATCCTTGATGGAAGCGTAAAAGT

TCCTGAAAAATAA

4193.3

ATGTCTAAAAAATTACAACAAATTTCGGTTCCCTTGATTTCTGTATTCCTAGGAATTTTACTCGGAGCCATTGTCAT

GTGGATCTTCGGTTATGATGCTATTTGGGGCTACGAAGAATTGTTCTATACAGCCTTTGGCAGTCTGCGTGGGATT

GGAGAAATCTTCCGTGCTATGGGTCCTCTGGTCTTGATTGGTCTTGGTTTTGCCGTTGCCAGTCGAGCTGGTTTCTT

TAACGTCGGACTTCCTGGTCAGGCTTTGGCAGGTTGGATTCTCAGTGGTTGGTTTGCCCTGTCGCATCCAGATATG

CCCCGTCCCTTGATGATTCTAGCAACCATCGTGATTGCCTTGATTGCTGGTGGGATTGTCGGAGCGATTCCAGGTA

TTCTTAGGGCCTATCTAGGGACGTCAGAGGTTATTGTAACCATCATGATGAACTACATTGTCTTGTATGTAGGGAA

TGCCTTTATCCATG?CTTTCCCTAAAGACTTCATGCAAAGTACAGATTCGACCATTCGTGTTGGGGCTAATGCAACC

TATCAGACACCTTGGTTGGCTGAGTTGACTGGTAACTCACGGATGAATATTGGTATTTTCTTTGCCATCATTGCCGT

TGCAGTTATTTGGTTCATGCTCAAGAAAACAACTCTTGGTTTTGAAATCCGTGCAGTTGGTCTTAATCCACATGCTT

CAGAATATGCTGGTATTTCTGCCAAGCGGACTATTATCCTATCTATGATTATTTCAGGTGCCTTGGCAGGTCTTGGT

GGAGCTGTTGAAGGTTTGGGAACCTTCCAGAACGTCTATGTTCAAG?GTTCGTCATTAGCTATCGGATTTAACGGAA

TGGCGGTTAGTTTGCTTGCGGCCAACTCACCAATTGGTATACTCTTTGCAGCCTTCCTATTTGGCGTTCTCCAAGTT

GGGGCTCCTGGTATGAATGCGGCGCAGGTACCATCTGAGCTTGTCAGCATTGTAACAGCGTCTATTATCTTCTTTG

TCAGTGTTCATTACCTTATCGAACGCTTTGTCAAACCGAAAAAACAAGTTAAAGGAGGTAAGTAA

4194.1

ATGGGAGTGAAAAAGAAACTAAAGTTGACTAGTTTGCTAGGACTGTCTCTGTTAATCATGACAGCCTGTGCGACT

AATGGGGTAACTAGCGATATTACAGCCGAATCGGCTGATTTTTGGAGTAAATTGGTTTACTTCTTTGCGGAAATCA

TTCGCTTTTTATCGTTTGATATTAGTATCGGAGTGGGGATTATTCTCTTTACGGTCTTGATTCGTACAGTCCTCTTG

CCAGTCTTTCAGGTGCAAATGGTGGCTTCTAGGAAAATGCAGGAAGCTCAGCCACGCATTAAGGCGCTTCGAGAA

CAATATCCAGGTCGAGATATGGAAAGCAGAACCAAACTAGAGCAGGAAATGCGTAAAGTATTTAAAGAAATGGG

TGTCAGACAGTCAGACTCTCTTTGGCCGATTTTGATTCAGATGCCGGTTATTTTGGCCCTGTTCCAAGCCCTATCAA

GAGTTGACTTTTTAAAGACAGGTCATTTCTTATGGATTAACCTTGGTAGTGTGGATACAACCCTTGTTCTTCCGATT

TTAGCAGCAGTATTCACCTTTTTAAGTACTTGGTTGTCCAACAAAGCTTTGTCTGAGCGAAATGGCGCTACGACTG

CGATGATGTATGGGATTCCAGTCTTGATTTTTATCTTTGCAGTTTATGCGCCAGGTGGAGTCGCCCTATACTGGAC

AGTGTCTAATGCTTATCAAGTCTTGCAAACCTATTTCTTGAATAATCCATTCAAGATTATCGCAGAGCGCGAGGCC

GTAGTACAGGCACAAAAAGATTTGGAAAATAGAAAAAGAAAAGCCAAGAAAAAGGCTCAGAAAACGAAATAA

4194.4

ATGGTTATCGATCCATTTGCTATCAACGAACTAGACTATTACTTAGTTTCACACTTCCACAGTGATCATATCGACC

CATACACAGCTGCAGCAATTCTCAATAATCCTAAGTTAGAGCATGTTAAGTTTATCGGTCCTTACCACTGTGGACG

AATCTGGGAAGGATGGGGTGTTCCAAAAGAACGTATCATCGTTGTTAAACCAGGTGACACTATCGAATTAAAAGA

TATGAAGATTCATGCAGTAGAATCATTTGACCGTACTTGCTTGGTAACTCTCCCAGTGAACGGTGCTGATGAGACA

GGCGGTGAACTTGCTGGCTTGGCTGTTACAGATGAAGAAATGGCTCAAAAGGCTGTTAACTATATCTTTGAAACAC

CAGGTGGAACCATCTATCATGGTGCAGATTCTCACTTCTCAAACTATTTTGCAAAACATGGTAAAGACTTTAAAAT

TGATGTTGCTTTGAATAACTATGGTGAAAATCCGGTAGGTATCCAAGACAAAATGACATCTATCGACCTTCTTCGT

ATGGCAGAAAATCTGCGTACCAAAGTCATTATCCCAGTTCACTATGATATCTGGTCTAACTTCATGGCTTCTACTA

ATGAGATTCTAGAACTTTGGAAAATGCGAAAAGATCGCTTGCAATACGATTTCCATCCATTTATCTGGGAAGTTGG

CGGTAAGTACACTTATCCTCAAGATCAACACTTAGTAGAATACCATCATCCACGTGGTTTTGATGATTGTTTTGAA

CAAGACTCTAACATTCAATTTAAAGCTTTGCTATAA

4196.2

ATGTTCCTTTCAGGCTGGTTGTCTAGTTTTGCTAATACTTATATCCATGATTTACTGGGGGTTCTTTTCCCAGATAG

TCCATTTTTAAATGCCTTTGAAAGTGCTATTGCGGCTCCTTTGGTAGAAGAACCCTTGAAATTATTGTCACTTGTTT

TTGTTTTGGCTTTGATTCCTGTGCG?AAAATTAAAATCTTTGTTTTTACTTGGAATTGCTTCCGGTTTGGGATTCCAA

ATGATTAAGGATATTGGTTATATTCGTACGGATTTGCCAGAGGGCTTTGACTTTACTATTTCGCGAATTTTAGAGC

GTATCATCTCAGGAATTGCCTCTCACTGGACTTTTTCAGGTCTAGCTGTAGTAGGTGTTTACTTGCTTTACAGAGCC

TATAAAGGACAGAAGGTTGGCAAGAAACAGGGCCTTATTTTTCTAGGTTTAGCCTTGGGAACTCACTTCTTGTTTA

ACTCTCCTTTTGTGGAGTTGGAAACAGAGTTGCCTTTAGCGATTCCAGTGGTTACGGCTATTGCTCTCTATGGTTTT

TATCATGCTTATTGCTTTGTTGAGAAACACAATGAGTTGATGACCTAG

4197.1

ATGAAGGTGGAACCACGTTGCGACGTCCTTTCGAGGATGTCGCATTTTTTTATTAGGATACTAATTATGGAGTTGC

AAGAATTAGTGGAGCGCAGTTGGGCAATCCGACAAGCTTATCACGAACTGGAAGTTAAGCATCATGATTCCAAGT

GGACGGTAGAAGAAGACCTCTTGGCTTTATCTAATGATATTGGAAATTTCCAACGACTGGTGATGACAAAGCAAG

GACGCTACTATGATGAAACACCCTACACACTGGAACAAAAACTTTCAGAAAATATCTGGTGGCTATTAGAACTTT

CTCAACGTTTGGATATAGACATTCTGACGGAAATGGAAAACTTCCTCTCTGATAAAGAAAAGCAATTGAACGTTA

GGACTTGGAAGTAG

4197.4

ATGCTTGATTGGAAACAATTTTTTCTAGCCTATCTGCGCTCCCGTAGTCGTCTTTTTATCTATCTGCTTTCTTTGGC

ATTTCTTGTCTTACTCTTTCAGTTTTTATTTGCCAGTCTAGGAATTTACTTCCTCTACTTTTTCTTCTTGTGTTGCTTT

GTAACCATATTATTTTTCACTTGGGACATATTGGTGGAAACGCAGGTCTATCGCCAGGAACTTCTCTATGGAGAGA

GGGAAGCCAAGTCTCCTTTGGAAATAGCTTTAGCAGAAAAATTAGAAGCGCGTGAGATGGAACTCTATCAGCAGA

GGTCAAAAGCAGAAAGAAAACTGACGGATTTGCTGGATTACTATACCTTGTGGGTCCATCAGATAAAGACCCCCA

TTGCAGCCAGTCAACTCTTAGTTGCAGAAGTGGTCGACCGCCAACTGAAGCAGCAGCTAGAACAGGAAATTTTCA

AAATCGACTCCTATACCAACCTAGTTTTACAGTACCTGCGTTTAGAAAGTTTCCATGATGATTTGGTCTTAAAGCA

GGTTCAAATTGAGGACTTGGTCAAGGAAATAATTCGTAAATATGCTCTTTTCTTTATTCAAAAAGGCTTAAATGTC

AATCTACATGACCTTGATAAAGAAATCGTGACGGATAAAAAGTGGCTGCTAGTGGTTATTGAGCAAATCATCTCA

AACAGTCTCAAGTACACCAAGGAAGGTGGTCTGGAGATTTATATGGATGACCAAGAGCTTTGTATCAAAGATACG

GGAATCGGGATAAAAAACAGTGATGTCCTCCGAGTATTTGAACGTGGCTTTTCAGGATACAATGGCCGTTTGACCC

AGCAGTCCTCTGGACTTGGCCTTTATCTATCTAAGAAAATTTCTGAAGAACTGGGGCACCAGATTCGTATCGAGTC

TGAGGTCGGAAAAGGAACGACAGTGCGGATTCAGTTTGCTCAAGTGAACTTAGTCCTTGAGTAA

4211.2

ATGGAACTTAATACACACAATGCTGAAATCTTGCTCAGTGCAGCTAATAAGTCCCACTATCCGCAGGATGAACTG

CCAGAGATTGCCCTAGCAGGGCGTTCAAATGTTGGTAAATCCAGCTTTATCAACACTATGTTGAACCGTAAGAATC

TCGCCCGTACATCAGGAAAACCTGGTAAAACCCAGCTCCTGAACTTTTTTAACATTGATGACAAGATGCGCTTTGT

GGATGTGCCTGGTTATGGCTATGCTCGTGTTTCTAAAAAGGAACGTGAAAAGTGGGGGTGCATGATTGAGGAGTA

CTTAACGACTCGGGAAAATCTCCGTGCGGTTGTCAGTCTAGTTGACCTTCGTCATGACCCGTCAGCAGATGATGTG

CAGATGTACGAATTTCTCAAGTATTATGAGATTCCAGTCATCATTGTGGCGACCAAGGCGGACAAGATTCCTCGTG

GTAAATGGAACAAGCATGAATCAGCAATCAAAAAGAAATTAAACTTTGACCCGAGTGACGATTTCATCCTCTTTTC

ATCTGTCAGTAAGGCAGGGATGGATGAGGCTTGGGATGCAATCTTAGAAAAATTGTGA

4211.3

ATGACAAAGAAACAACTTCACTTGGTGATTGTGACAGGGATGAGTGGCGCAGGGAAAACTGTAGCCATTCAGTCC

TTCGAGGATCTAGGTTATTTCACCATTGATAATATGCCGCCAGCTCTCTTGCCTAAGTTTTTGCAGCTGGTTGAAAT

TAAGGAAGACAATCCTAAGTTGGCCTTGGTAGTGGATATGCGTAGCCGTTCTTTCTTTTCAGAGATTCAAGCTGTT

TTGGATGAGTTGGAAAATCAAGATGGTTTGGATTTCAAAATCCTCTTTTTGGATGCGGCTGATAAGGAATTGGTCG

CTCGTTACAAGGAAACCAGACGGAGTCACCCACTAGCAGCAGACGGTCGTATTTTAGATGGAATCAAGTTGGAAC

GTGAACTCTTGGCACCTTTGAAAAATATGAGCCAAAATGTGGTGGATACGACTGAACTCACTCCACGTGAGcTGCG

CAAAACCCTTGCAGAGCAGTTTTCAGACCAAGAACAAGCCCAGTCTTTCCGTATCGAAGTCATGTCTTTCGGATTT

AAGTATGGAATCCCGATTGATGCGGACTTGGTCTTTGATGTCCGTTTCTTGCCAAATCCCTATTATTTACCAGAACT

GAGAAACCAAACGGGTGTGGATGAACCTGTTTATGATTATGTCATGAACCATCCTGAGTCAGAAGACTTTTATCAA

CATTTATTGGCCTTGATTGAGCCGATTCTGCCAAGTTACCAAAAGGAAGGTAAGTCCGTTTTGACCATTGCCATGG

GATGTACGGGTGGACAACACCGTAGTGTGGCATTTGCTAAACGCTTGGCGCAGGACTTATCCAAGAATTGGTCTGT

TAATGAAGGGCATCGCGACAAAGACCGCAGAAAGGAAACGGTAAACCGTTCATGA

4211.4

ATGAGAAAACCAAAGATAACGGTGATTGGTGGAGGGACTGGAAGTCCCGTCATTCTAAAAAGTCTGCGGGAAAAA

GATGTGGAAATCGCAGCTATCGTGACGGTGGCAGATGATGGTGGTTCTTCAGGTGAACTCCGAAAAAATATGCAA

CAGTTGACACCGCCAGGTGATCTTCGTAATGTCCTTGTGGCCATGTCGGATATGCCTAAGTTTTATGAGAAGGTCT

TTCAGTATCGGTTCTCTGAGGATGCCGGAGCCTTTGCTGGCCATCCATTGGGAAATCTCATCATTGCTGGCTTGTC

AGAAATGCAGGGTTCAACCTATAATGCCATGCAGTTATTGAGCAAATTTTTCCATACAACAGGGAAAATTTATCCT

TCCAGTGACCATCCTTTGACCCTTCATGCAGTCTTTCAGGATGGGACAGAAGTGGCTGGAGAGAGTCATATTGTAG

ACCATCGAGGCATAATTGACAATGTCTATGTGACCAATGCCCTAAACGATGATACGCCTCTGGCCAGCCGTCGAG

TAGTGCAGACCATCCTTGAAAGTGACATGATTGTCCTAGGGCCAGGTTCCCTCTTTACCTCTATTTTGCCCAATAT

CGTGATTAAGGAAATTGGGCGGGCTCTTTTGGAAACCAAGGCAGAAATTGCCTATGTCTGCAATATCATGACCCA

ACGTGGGGAGACGGAACACTTTACAGATAGCGACCACGTGGAAGTCTTGCATCGTCACCTTGGTCGCCCTTTTATC

GACACTGTCTTGGTGAATATTGAAAAAGTGCCTCAGGAATACATGAATTCCAACCGTTTTGATGAATACTTAGTGC

AAGTGGAACACGATTTTGTAGGTCTTTGTAAGCAAGTTTCGCGCGTGATTTCATCTAACTTCCTTCGTCTGGAAAA

TGGCGGTGCCTTCCACGATGGAGATTTGATTGTGGACGAGTTGATG?CGCATTATACAGGTGAAAAAATGA

4213.1

ATGAAAAATTTGATAAAGTTGCTAATAATTAGATTGATTGTTAACTTAGCAGACAGTGTATTTTATATAGTAGCAT

TGTGGCACGTTAGCAATAATTATTCTTCGAGCATGTTCTTAGGAATATTTATTGCAGTAAATTATCTACCGGATTTG

TTACTAATCTTTTTTGGACCAGTTATTGACAGAGTAAATCCGCAAAAAATTCTTATAATATCAATTTTGGTTCAATT

AGCAGTGGCTGTAATATTTTTATTATTATTAAACCAAATATCATTTTGGGTGATAATGAGTCTAGTGTTTATTTCAG

TAATGGCTAGCTCCATAAGTTACGTGATAGAAGATGTGTTGATTCCTCAAGTGGTAGAATATGATAAGATTGTATT

TGCAAATTCTCTTTTTAGTATTTCGTATAAAGTATTAGATTCTATTTTTAATTCATTCGCATCATTTTTACAGGTGG

CAGTAGGATTTATTTTATTGGTTAAGATAGATATAGGCATATTTTTACTTGCTCTATTTATATTGTTGTTGTTAAAA

TTTAGAACTAGCAATGCGAATATAGAAAACTTCTCTTTCAAATATTACAAGAGAGAAGTGTTGCAAGGTACAAAG

TTTATTTTAAATAATAAATTATTATTTAAAACCAGTATTTCTTTAACGCTTATAAACTTTTTTTATTCATTTCAGACA

GTAGTTGTACCGATTTTTTCTATTCGATATTTTGATGGTCCGATTTTTTATGGTATTTTTTTAACTATTGCTGGTTTG

GGTGGTATATTGGGAAATATGCTAGCGCCAATCGTAATAAAATATTTAAAATCGAATCAAATTGTTGGTGTATTTC

TTTTTTTGAACGGCTCAAGTTGGTTAGTAGCAATTGTTATAAAAGACTATACTTTATCACTTATTTTATTTTTCGTTT

GTTTTATGTCTAAAGGAGTCTTCAATATTATTTTTAATTCGTTGTACCAACAAATACCTCCACATCAACTTCTTGGT

AGGGTAAATACTACCATTGATTCTATTATTTCTTTTGGAATGCCAATTGGTAGTTTAGTTGCAGGAACGCTTATTGA

TTTGAATATTGAATTAGTGTTAATTGCTATTAGCATACCTTATTTTTTGTTTTCTTATATTTTTTATACGGATAATGG

ATTGAAAGAATTTAGTATATATTAG

4213.2

ATGATGTCTAACAAAAATAAGGAAATTCTGATTTTTGCGATTCTCTATACAGTCCTCTTTATGTTTGATGGCGTTAA

ATTGCTGGCTTCTTTAATGCCATCTGCCATTGCAAATTATCTTGTTTATGTAGTTTTAGCTCTATATGGCTCCTTCTT

GTTCAAGGATAGATTGATCCAACAATGGAAGGAGATTAGAAAGACTAAAAGAAAATTCTTCTTTGGAGTCTTAAC

AGGATGGCTCTTTCTCATTCTGATGACTGTTGTCTTTGAATTTGTATCAGAGATGTTGAAGCAGTTTGTGGGACTAG

ATGGACAAGGTCTAAATCAGTCTAATATTCAAAGTACCTTTCAAGAACAACCACTACTGATAGCTGTTTTTGCTTG

TGTCATTGGACCTCTGGTAGAAGAATTATTTTTCCGTCAGGTCTTATTGCATTACTTGCAGGAACGGTTGTCAGGTT

TACTAAGCATTATTCTGGTAGGACTTGTTTTTGCTCTGACTCATATGCACAGTTTGGCTCTATCAGAGTGGATTGGT

GCAGTTGGTTACTTAGGTGGAGGCCTTGCCTTTTCTATTATTTATGTGAAAGAAAAAGAGAATATCTACTATCCCC

TACTTGTTCACATGTTAAGCAACAGCCTCTCCTTAATCATTTTAGCTATCAGTATAGTAAAATGA

4224.1

TTGAAAAAGCCAATTATCGAATTCAAAAACGTCTCTAAAGTTTTTGAAGACAGCAACACCAAGGTTCTCAAAGAC

ATCAACTTTGAGTTGGAAGAAGGGAAATTCTACACCCTTCTAGGTGCATCTGGTTCGGGGAAATCAACTATCCTAA

ACATTATTGCAGGTTTACTGGATGCGACGACAGGAGATATCATGCTAGACGGTGTTCGTATCAATGATATTCCAAC

CAACAAGCGCGACGTACATACCGTCTTCCAATCCTATGCCTTGTTCCCACATATGAATGTGTTTGAAAATGTTGCC

TTTCCACTTCGCTTGCGTAAAATTGATAAGAAAGAAATCGAGCAGCGTGTAGCGGAAGTTCTCAAGATGGTTCAGT

TGGAAGGTTATGAAAAACGTTCCATCCGCAAACTTTCTGGAGGACAACGTCAGCGTGTGGCCATCGCCCGTGCTA

TCATCAACCAACCCCGTGTGGTCTTGTTGGACGAGCCTTTATCAGCGCTGGACTTGAAATTGAGAACAGACATGCA

GTACGAATTGCGTGAATTACAACAACGATTGGGCATTACCTTTGTCTTTGTCACTCACGATCAGGAAGAAGCTCTT

GCCATGAGTGACTGGATTTTCGTTATGAATGATGGCGAGATTGTCCAGTCTGGAACCCCTGTGGACATCTACGATG

AGCCAATCAACCACTTTGTTGCCACCTTTATCGGGGAGTCAAACATCTTGCCAGGTACCATGATTGAGGACTACTT

GGTCGAATTTAACGGCAAACGCTTTGAAGCGGTTGATGGTGGGATGAAGCCAAATGAACCTGTTGAGGTCGTTAT

TCGTCCAGAGGACTTGCGCATTACCCTTCCTGAAGAAGGCAAGCTCCAAGTTAAGGTCGATACCCAGCTTTTCCGT

GGAGTTCATTATGAAATTATCGCCTATGACGAACTTGGAAATGAATGGATGATCCACTCAACCCGTAAGGCTATCG

TGGGTGAGGAAATCGGTCTGGACTTTGAACCAGAAGACATCCACATCATGCGTCTCAATGAAACCGAAGAAGAGT

TCGATGCTCGTATTGAGGAGTACGTAGAAATCGAAGAGCAAGAAGCAGGTTTGATCAATGCAATCGAGGAGGAAA

GAGATGAAGAAAACAAGCTCTAA

4252.1

ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAAT

GCATCTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGT

AAATTATCTTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGT

ATGTTACTCTTAATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCA

AGAATTAGTTGACTTTTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAA

ATACGTGCGCGATTTTCTTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTC

TTAAGAAATCCAATGACCATTGTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCC

AAATTCGGTTAAGAAGGAAGTTTCCTTTTA?TGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTT

TCTTTTAG

4252.2

ATGGTTAAAAAAATTATTGGAATGGTGCTAGCTTTACTTTCTGTAACTGTAGTAGGAGTAGGTGTTTTTGCTTATAC

TATTTATCAACAAGGGACAGAAACCTTAGCTAAAACCTATAAAAAAATCGGTGAAGAAACCAAGGTTATTGAAGC

GACTGAACCTCTAACCATTCTGTTAATGGGAGTGGACACCGGAAATGTTGAACGAACTGAAACTTGGGTCGGTAG

AAGTGATAGCATGATCTTGATGACAGTGAATCCTAAAACGAAAAAAACAACAATGATGAGTTTAGAGCGGGATAT

TCTGACGCGCATTGAATCAGGGAATGGTCAGGCTCATGAAGCGAAACTGAACTCAGCATATGCAGATGGTGGAGC

AGAGCTTGCTATAGAAACCATTCAAAAAATGATGAATATCCATATTGATCGCTATGTGATGGTCAATATGAGAGG

ATTGCAAAAACTAGTGGATGCAGTAGGAGGTATTACAGTCAATAATATCCTAGGTTTCCCAATTTCTATCAGTGAC

CAAGAAGAATTTAATACTATTTCTATCGGTGTTGGGGAGCAACATATTGGGGGAGAAGAAGCCCTAGTCTATGCA

CGAATGCGTTACCAAGATCCTGAGGGGGATTATGGTCGTCAAAAACGTCAACGTGAAGTTATTCAAAAAGTCATG

GAAAAAGCTCTCAGTTTAAATAGCATTGGTCATTATCAAGAGATTCTAAAAGCTTTGAGTGACAATATGCAGACC

AATATTGATTTGTCTGCAAAAAGTATCCCTAACTTGCTAGGCTATAAAGATTCATTTAAAACCATTGAAACTCAGC

AGTTGCAGGGTGAAGGAGAGATACTTCAAGGTGTTTCTTACCAGATTGTTTCGAGAGCACATATGTTGGAAATGCA

AAATCTACTCCGACGTTCTTTGGGACAAGAAGAAGTTACTCAGCTTGAAACCAATGCGGTTTTATTTGAAGATTTA

TTTGGCAGAGCACCTGTTGGTGATGAAGATAATTAA

ATGAAAAAACAAGCCTATGTCATTATTGCTCTCACCTCCTTCCTATTTGTCTTTTTTTTCTCCCACAGCTTGCTGGA

AATACTTGATTTTGACTGGTCTATCTTTTTGCACGATGTCGAAAAAACAGAAAAATTTGTCTTTTTATTGTTGGTTT

TCAGCATGTCCATGACCTGTCTCTTAGCCCTGTTTTGGCGAGGGATCGAAGAGCTTTCTCTAAGAAAAATGCAGGC

TAATCTCAAGCGTTTATTAGCAGGGCAAGAAGTGGTTCAGGTTGCAGATCCAGATTTGGATGCCAGTTTCAAGTCC

TTATCAGGTAAACTTAACCTTTTGACAGAGGCTCTTCAAAAAGCTGAAAATCAGAGCCTTGCTCAGGAAGAGGAA

ATCATCGAGAAGGAACGGAAGCGAATTGCTCGGGATTTGCACGATACAGTCAGTCAGGAGTTGTTTGCGGCCCAC

ATGATTTTATCGGGTATCAGTCAGCAGGCTTTGAAATTGGATAGAGAAAAGATGCAGACCCAGTTGCAGAGTGTC

ACAGCTATTTTAGAAACAGCCCAGAAGGATTTGCGGGTTTTGCTCTTGCATTTGCGACCAGTTGAACTGGAGCAGA

AGAGCTTGATAGAAGGGATTCAAATTCTTTTAAAAGAGCTTGAGGACAAGAGTGATCTTAGGGTTAGTCTCAAGC

AGAATATGACGAAATTGCCTAAGAAAATCGAGGAGCATATCTTCCGTATCCTGCAAGAGTTGATTAGCAATACCC

TCCGCCATGCCCAGGCATCTTGCCTAGATGTCTACCTCTATCAGACAGATGTTGAATTGCAACTGAAGGTGGTGGA

CAATGGGATTGGTTTCCAGTTAGGGAGCTTAGACGACTTGAGTTATGGACTGCGAAATATCAAGGAGCGGGTTGA

AGATATGGCTGGAACAGTTCAACTCTTGACAGCTCCCAAGCAAGGGCTGGCGGTTGATATCCGTATTCCCCTGTTA

GATAAGGAATGA

4263.1

ATGATTGTTTCCATTATTTCTCAAGGATTTGTCTGGGCTATTCTAGGTCTGGGAATCTTTATGACATTTAGGATTTT

AAACTTTCCAGATATGACGACAGAAGGTTCCTTCCCTCTTGGGGGAGCTGTTGCTGTCACTTTGATAACCAAAGGC

GTGAACCCATTTTTAGCGACACTTGTTGCTGTAGGAGCAGGTTGTTTGGCTGGAATGGCAGCAGGCCTTCTTTATA

CAAAAGGAAGATCCCAACCTTGCTCTCAGGGATTTTGGTGATGACTTCTTGTCACTCAATCATGCTCTTGATTAT

GGGACGTGCGAATTTAGGCCTGCTTGGAACCAAGCAAATTCAGGATGTTTTGCCTTTTGATTCGGATTTGAATCAA

CTCTTGACAGGTCTCATCTTTGTGAGTATTGTTATTGCTCTCATGCTCCTTTTTCTTGGACACTAAACTCGGACAAGC

CTATATTGCTACAGGGGATAATCCTGATATGGCTAGAAGTTTCGGGATTCATACTGGACGCATGGAGCTCATGGGC

TTGGTCTTATCAAATGGTGTG?ATTGCCCTTGCAGGTGCCCTCATTGCTCAGCAAGAAGGTTATGCCGATGTGTCTC

GAGGGATCGGGGTTATCGTTGTGGGGCTTGCAAGTTTGATTATTGGAGAAGTTATTTTCAAGAGTTTGAGCTTGGC

AGAGCGTTTGGTTACTATCGTTGTAGGTTCTATCGCTTATCAATTTTTAGTGTGGGCAGTTATCGCACTTGGCTTTA

ATACAAGTTACCTTCGTTTATACAGTGCCTTGATTTTAGCAGTCTGCCTCATGATTCCAACATTTAAGCAAACAAT

CTTGAAAGGAGCCAAGTTAAGCAAATGA

4346.1

ATGAAAAAAATGAAAGTTTGGTCTACTGTACTTGCAACGGGAGTTGCTCTTACTACACTTGCTGCTTGCTCTGGAG

GTTCAAATTCTACGACTGCTTCTTCATCTGAAGAAAAAGCTGATAAAAGTCAAGAATTAGTTATCTATTCGAACTC

AGTCTCAAATGGTCGTGGTGATTGGTTAACTGCTAAAGCAAAAGAAGCTGGTTTTAATATAAAAATGGTTGATATC

GCTGGCGCTCAATTAGCAGACCGTGTTATTGCTGAGAAGAATAATGCAGTTGCAGATATGGTATTTGGAATTGGTG

CTGTTGATTCAAATAAAATTAGAGATCAAAAATTACTAGTACAGTACAAGCCTAAATGGTTAGATAAAATTGATC

AATCTTTATCAGATAAAGATAATTATTATAATCCTGTGATTGTTCAACCATTAGTTTTAATTGGGGCGCCTGATGTA

AAAGAAATGCCTAAAGATTGGACTGAATTAGGTAGTAAGTATAAAGGTAAATATTCAATTTCTGGTCTTCAAGGA

GGTACAGGACGGGCAATTCTAGCAAGTATCTTAGTTCGATACCTTGATGATAAAGGTGAATTAGGTGTTTCCGAAA

AAGGTTGGGAAGTAGCAAAAGAATATTTGAAAAATGCATACACTCTTCAAAAGGGAGAAAGTTCAATTGTTAAGA

TGTTAGACAAAGAAGATCCAATACAATATGGAATGATGTGGGGTTCTGGTGCATTAGTTGGACAAAAAGAACAAA

ATGTTGTTTTCAAAGTTATGACTCCTGAGATTGGTGTACCATTTGTAACTGAACAAACTATGGTTTTAAGCACTAG

TAAAAAACAAGCGTTAGCTAAAGAATTTATTGATTGGTTTGGTCAATCAGAAATTCAAGTAGAATATAGTAAGAA

CTTTGGATCTATTCCTGCAAATAAAGATGCCCTCAAAGATCTACCTGAAGATACGAAGAAATTTGTTGATCAAGTG

AAACCACAAAATATTGACTGGGAAGCTGTTGGAAAGCATTTGGATGAATGGGTAGAAAAAGCTGAATTAGAATAC

GTACAATAA

4346.2

ATGATTAAATTTGATAATATTCAAATTAAATATGGTGATTTTGTTGCAATTGATAATCTGAATTTAGATATACATG

AAGGGGAATTTTTTACATTTCTTGGGCCTTCAGGATGTGGTAAATCAACTACTTTGAGAGCATTGGTAGGTTTTCT

AGATCCATCATCAGGAAGTATTGAAGTTAATGGAACAGATGTCACTCATTTGGAACCTGAAAAGCGTGG?AATTGG

TATTGTATTTCAATCTTATGCGCTATTTCCAACTATGACTGTTTTTGATAATATTGCATTTGGTTTAAAAGTTAAGA

AGGTAGCTCCAGATGTTATTAAAGCTAAAGTATCAGCAGTGGCAGCAAAAATTAAGATCTCTGATCAACAGTTAC

AGCGTAATGTATCAGAATTATCTGGGGGTCAACAACAAAGGGTAGCATTGGCTCGTGCTCTGGTTCTTGAACCTAA

AATTCTTTGTCTAGATGAACCATTGTCAAACCTTGACGCAAAATTACGTGTAGATTTGAGAAAAGAGTTGAAAAGA

CTTCAAAAAGAGTTAGGTATTACTACTTTATATGTTACTCATGATCAAGAGGAAGCCTTGACTTTATCTGATAGAA

TTGCAGTCTTTAACAATGGATACATCGAACAGGTCGGTACACCAGTAGAGATTTATCATAATTCTCAAACTGAATT

TGTATGTGATTTTATTGGAGATATTAATGTTTTGACCGATGAAACAGTCCACGAAGTATTATTGAAAAATACAAGC

GTTTTCTTAGAGGATAAAAAAGGATACATTCGATTAGAGAAAGTTCGATTCAATCGTGAAACTGAACAAGATTTTA

TTCTAAAAGGGACAATTATTGATGTTGAGTTTTCTGGAGTTACAATTCACTATACAATAAAAGTTTCTGAAAGTCA

GATTCTTAATGTAACAAGTATTGATAGTCAGGCTGCTATTAGATCTGTCGGAGAAAGTGTGGAATTATTTATCACA

CCATCAGACGTTCTGCAATTTTAA

4346.3

ATGCGTCATAAATTAAATTTAAAAGATTGGCTTATTCGTTTAGGGTTAATCTGGTTCTTAGTAACATTTATTATTTA

TCCAAACTTTGATCTAGTAGTGAATGTATTTGTAAAAGGAGGAGAATTTTCCCTTGATGCTGTACATCGTGTTCTA

AAATCTCAGAGGGCACTTCAGAGTATTATGAACAGTTTTAAGTTAGCATTTTCACTCATTATTACAGTTAATGTCG

TAGGTATTCTTTGTGTTCTATTTACAGAGTACTTTGATATTAAAGGTGCTAAAATTTTAAAATTAGGTTATATGACC

TCTTTAATTTATGGAGGAGTGGTTTTAGCGACTGGATATAAATTTGTCTATGGTCCTTATGGATTGATTACAAAATT

TTTACAAAATGTTATCCCTTCTTTAGACCCTAACTGGTTTATTGGGTATGGTGCAGTCTTATTCATTATGACATTTT

CAGGAACTGCTAATCATACATTGTTTTTAACAAATACAATTCGAAGCGTTGACTATCACACTATTGAGGCTGCTCG

AA?ATATGGGAGCAAAACCATTTACTGTTTTCCGAAAAGTAGTGTTACCAACCTTAATTCCAACTCTATTTGCACTT

ACTATTATGGTTTTTCTTAGTGGTTTATCTGCAGTAGCAGCACCCATGATTGTTGGTGGTAAAGAATTTCAAACTAT

AAATCCAATGATTATTACATTTGCAGGGATGGGGAATTCTCGTGATTTAGCTGCCCTACTTGCAATTATTTTAGGT

ATTGCAACTACAATTTTGCTTACTATCATGAATAAGATAGAAAAAGGTGGAAATTATATTTCTATCTCTAAGACTA

AAGCGCCTCTTAAAAAACAAAAAATTGCGTCTAAGCCTTGGAATATCATTGCTCACATTGTAGCATATGGATTGTT

CACAGTTTTCATGCTTCCACTAATTTTTATAGTATTATACTCATTTACAGATCCAGTTGCAATTCAAACAGGTAACT

TAACATTATCAAACTTTACTTTAGAAAATTATCGCTTATTCTTTAGTAATAGTGCGGCATTCTCTCCATTCTTGGTC

AGCTTTATTTATTCTATTATTGCTGCGACAACAGCAACAATTCTCG?CAGTTGTATTTGCTCGTGTTGTCAGAAAACA

TAAATCTCGTTTTGATTTCTTATTTGAATATGGTGCTCTACTTCCTTGGTTACTACCAAGTACACTTTTAGCAGTAA

GTTTATTATTTACTTTTAATCAGCCACAATTTCTTGTCTTGAATCAGATTTTGGTAGGTAGTTTGGTAATTCTACTT

ATTGCATATATAGTTGTAAAAATCCCATTTTCTTATAGAATGGTACGTGCTATTTTATTTAGTGTTGATGATGAGAT

GGAAGATGCAGCAAGAAGTATGGGTGCTTCACCTTTTTATACTATGATGAAGGTTATCATTCCATTTATTTTACCG

GTTGTTCTCTCTGTTATTGCTTTAAACTTTAACTCTTTATTAACTGACTTCGACTTATCTGTATTCCTTTACCATCCC

CTAGCTCAACCATTAGGTATTACGATTCGATCTGCAGGTGATGAAACAGCAACATCTAATGCACAAGCTCTGGTAT

TTGTTTATACAATTGTTCTGATGATTATTTCTGGAACGGTATTATACTTCACACAAAGACCGGGGCGTAAAGTAAG

GAAATAA

Table 2

MEELVTLDCLFIDRTKIEANANKYSFVWKKTTEKFSAKLQEQIQVYFQEEITPLLIKYAMFDKKQKRGYKESAKNLANW

HYNDKEDSYTHPDGWYYRFHHTKYQKTQTDFQQEIKVYYADEPESAPQKGLYMNERYQNLKAKECQALLSPQGRQIF

AQRKIDVEPVFGQIKASLGYKRCNLRGKRQVRIDMGLVLMANNLLKYSKMKZ

MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVYADETLITHTAEKPKEEKMIVEEKADKALETKNIV

ERTEQSEPSSTEAIASEKKEDEAVTPKEEKVSAKPEEKAPRIESQASNQEKPLKEDAKAVTNEEVNQMIEDRKVDFNQN

WYFKLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTFKLDEKDLKKNVRLTF

DGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLQKDGRENVIAVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHV

EKNGTTILTPKLEEQQHGKVETHVTSKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVER

PKLWTVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLHHDHGALGAEENYKAE

YRRLKQMKEMGVNSIRTTHNPASEQTLQLAAELGLLVQEEAFDTWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFD

LRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDA

VGFNYSEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDRVGWGKTATASWTFD

RDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAGIPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENK

ELASKVADSEGKIPVRAYSNASSVELFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDES

GKEIARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHGQGQLVGVDNGEQASRER

YKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLKSNQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPT

TVPFVYSDGSRAERPVTWSSVDVSKPGIVTVKGMADGREVEARVEVIALKSELPVVKRIAPNTDLNSVDKSVSYVLIDGS

VEEYEVDKWEIAEEDKAKLAIPGSRIQATGYLEGQPIHATLVVEEGNPAAPAVPTVTVGGEAVTGLTSQKPMQYRTLA

YGAKLPEVTASAKNAAVTVLQASAANGMRASIFIQPKDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSV

RAHYQDGTQAVLPADKVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKDQVELTIQANTEKKIAQSIRPVNVVT

DLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQTFEVLGKVEGIDLEARAKVSVEGIVSVEEVSVTTPIAEAP

QLPESVRTYDSNGHVSSAKVAWDAIRPEQYAKEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAF

ASDS?NPSDPVSNVNDKLISYNNQPANRWTNWNRTNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVGVPKSYVIEY

YVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHFSFDKVETYAVRIRMVKADNKRGTSITEV

QIFAKQVAAAKQGQTRIQVDGKDLANFNPDLTDYYLESVDGKVPAVTASVSNNGLATVVPSVREGEPVRVIAKAENGD

ILGEYRLHFTKDKSLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLTVEWEEVPAENLTKAGQFTVR

GRVLGSNLVAEITVRVTDKLGETLSDNPNYDENSNQAFASATNDIDKNSHDRVDYLNDGDHSENRRWTNWSPTPSSNP

EVSAGVIFRENGKIVERTVTQGKVQFFADSGTDAPSKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYR

ADKDIAAGDEINVTFKAIKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELADFAENRQDYQIT

YKGQRPKVSVEENNQVASTVVDSGEDSFPVLVRLVSESGKQVKEYRIHLTKEKPVSEKTVAAVQEDLPKIEFVEKDLAY

KTVEKKDSTLYLGETRVEQEGKVGKERIFTAINPDGSKEEKLREVVEVPTDRIVLVGTKPVAQEAKKPQVSEKADTKPID

SSEASQTNKAQLPSTGSAASQAAVAAGLTLLGLSAGLVVTKGKKEDZ

MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVT

TDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGG

GESYKLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDN

INGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGV

IIVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSEL

GLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKFWKKHYQZ

MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFILDWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLP

PEESSSDLVINGKAPFAVYFQDYMAKKLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAML

KTLVESQGGDFEKVEKVPNNDSNSITPIANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYVKEFDYYSPVIIANND

YLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKEKRDFVIESQKYLSKEYASDKEKWGQFDAARWNAFY

KWDKENGILKEDLTDKGFTNEFVKZ

MKRTWRNSFVTNLNTPFMIGNIEIPNRTVLAPMAGVTNSAFRTIAKELGAGLVVMEMVSDKGIQYNNEKTLHMLHIDE

GENPVSIQLFGSDEDSLARAAEFIQENTKTDIVDINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMR

TGWADPSLAVENALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAKQRIEEVGA

DAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLINLKGENVAVREFRGLAPHYLRGTSGAAKL

RGAISQASTLAEIETLLQLEKAZ

MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGEKFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLK

RDIVDKRLPLVHDLDIKDGKLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFSYF

YTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIYELESRNEQIVKLQNQKVSFVRGAS

HELKTPLASLRIILENMQHNIGDYKDHPKYIAKSINKIDQMSHLLEEVLESSKFQEWTECRETTVKPVLVDILSRYQELAH

SIGVTIENQLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEHLFDIFYHSQIVTD

KDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISLZ

MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLTKYVTLLNDKALDSGLELAIHSEDENLRLSIGAATK

GRDIRSLFLESAVKYQILVYLLYHQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIHYFYFCL

FRKVWSSQEWEGHMQKPERKQEIANLEEICGASLSAGQKLDLVLWAHISQQRLRVNACQFQVIEEKMRGYFDNIFYLR

LLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLHTMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYEL

SQLCAQVYLYKGYILQDRYKYQLENRHPYLLMEHDFKETAEEIFHALPAFQQGTDLDKKILWEWLQLIEYMAENGGQ

HMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKEQTPVYYLKNDLDMEDLVAIRQLLF

TZ

MEFSKKTRELSIKKMQERTLDLLIIGGGITGAGVALQAAASGLETGLIEMQDFAEGTSSRSTKLVHGGLRYLKQFDVEV

VSDTVSERAVVQQIAPHIPKSDPMLLPVYDEDGATFSLFRLKVAMDLYDLLAGVSNTPAANKVLSKDQVLERQPNLKK

EGLVGGGVYLDFRNNDARLVIENIKRANQDGALIANHVKAEGFLFDESGKITGVVARDLLTDQVFEIKARLVINTTGPW

SDKVRNLSNKGTQFSQMRPTKGVHLVVDSSKIKVSQPVYFDTGLGDGRMVFVLPRENKTYFGTTDTDYTGDLEHPKVT

QEDVDYLLGIVNNRFPESNTTIDDIESSWAGLRPLIAGNSASDYNGGNNGTISDESFDNLIATVESYLSKEKTREDVESAV

SKLESSTSEKHLDPSAVSRGSSLDRDDNGLLTLAGGKITDYRKMAEGAMERVVDILKAEFDRSFKLINSKTYPVSGGELN

PANVDSEIEAFAQLGVSRGLDSKEAHYLANLYGSNAPKVFALAHSLEQAPGLSLADTLSLHYAMRNELTLSPVDFLLRR

TNHMLFMRDSLDSIVEPILDEMGRFYDWTEEEKATYRADVEAALANNDLAELKNZ

MMNELFGEFLGTLILILLGNGVVAGVVLPKTKSNSSGWIVITMGWGIAVAVAVFVSGKLSPAYLNPAVTIGVALKGGLP

WASVLPYILAQFAGAMLGQILVWLQFKPHYEAEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQA

GIGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPINKGDGDWSYAWIPVVGPVIGAALAVLVFSLFZ

MTKKKIERISVIHREKILWLKWYFMRDKEQPKYSVLERKMFDAAKNQDMLAYQKYATIKQITDIRVQTSEADILEAVKE

VYVYNHMNVIGACQRILFISQSPAYDKLNKWFNIYSDLYFSVVPLPKMGVYHEMVGIZ

MKNSNEAEMKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLEYLSQQASFSITVTRFAQMARYLVL

NDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIF

EKVTAYLNQGQLAQESQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFS

EGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELEL

VARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINL

LRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAEKLLQKWSV

FLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVL

VQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLF

LSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVI

GKKLDQQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLHPDARSHGNFL

HRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQ

AFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMA

EPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRF

AINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNRZ

MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSAQNILVSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVK

AATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLILENE

VFHEVFEAHYQGKQKETFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTE

QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLARVVAISKEKNGRALTNASRKA

DLKPLADAYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQ?ENAFEFADISHYTIE

ILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEG

RLIILKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAAFLLYDKDDTGEEEESQTETKL

TGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQD

YALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKT

HSLYDLIWKIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKD

AVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIKLSIPSLTYRQNEEE

LQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNF

SYRFIGEDQLTREAIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDM

EGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLKQVQTSQAVRDKINLDKILAF

FDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALY

EEALSRAYSIENIEKYLILLGKDEVQVVKVZ

MELARHAESLGVDAIATIPPIYFRLPEYSVAKYWNDISSAAPNTDYVIYNIPQLAGVALTPSLYTEMLKNPRVIGVKNSS

MPVQDIQTFVSLGGEDHIVFNGPDEQFLGGRLMGARAGIGGTYGAMPELFLKLNQLIADKDLETARELQYAINAIIGKL

TSAHGNMYGVIKEVLKINEGLNIGSVRSPLTPVTEEDRPVVEAAAALIRETKERFLZ

MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNTMDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLG

RGKKEEVASDFYQFIYLALGLSVVLLGMVLFLAPIILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLTKL

SMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQEKLKALHLEKRIPLNMDKIKEGV

RLGLPIGGTVFAEVAIFSVVGLIMAKFSPLIIASHQSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRW

TALIFAAFTLTFLYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYLGLLGYWGVAIP

VYAIZ

MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKA

PINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEEL

PVIDELEIQAQESQLFGERIEEDENQZ

MDTMISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVIFNTAKLATDIENNVRVVVYIRKDVEDNSQTIE

KEGQTVTNNDYHKVYDSLKNMSTVKSVTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANTPNDVKTIAEDA

KKIEGVSEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMRLVGAKNSYIRGPFLLEGAFIG

LLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPDLFSPLMIALLFVIGVFIGSLGSGISMRRFLKIZ

MKKVRFIFLALLFFLASPEGAMASDGTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYF

YLKSGGYMAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKADGQHAEKEW

LQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFYIKENGNYADKEWIFENGHYYYLKSGGY

MAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYD

SHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSDGK

WLGGKTTNENAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTEDLQALDASKD

FIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLENPFLFKDLTEATNYSAEELDKVFSLLNI

NNSLLENKGATFKEAEEHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILGATKWI

KENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKDZ

MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLTYNYKFVGLNNFKLLFMDPKFMNAIGFTAIIAIAM

VVGEIALGIFIARVLNSKIKGQTFFRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFFQTSLLGTKWGAIFAAVF

VLLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSMVFILALKGGLTAFDQVFAMTGGGPNN

ATTSLGLLVYNYAFKNNQFGYANAIAVILFFLIVVISIIQLRVSKKFEIZ

MMKQDERKALIGKYILLILGSVLILVPLLATLFSSFKPTKDIVDNFFGFPTNFTWDNFSRLLADGIGGYYWNSVVTTVLSL

LAVMIFIPMAAYSIARNMSKRKAFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGYIKI

SIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVLNRDSKMWTLPLFQYNYAGQYFND

YGPSFASYVVGIISITIVYLFFQ?RHIISGMSNGAVKZ

MKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQSILSHKFFRLILQFVLFGSVLSAAFASLEH

FQIVKKFNYAFLSPNMQVWHQNRAEVTFFNPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRT

AFPAIIAGAIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMALFKQNPFWGEGPLTYM

NSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRLMMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQS

GFIFLLVMCSIPLEHRMLVSDMTDZ

MSKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLIMGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAI

MGLISCFSIAYSYAKNSGVEALPAGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIKRKIV

IKMPEQVPQAIAKQFEAMIPAFVIFLSSMIVYILAKSLTNGGTFIEMIYSAIQVPLQGLTGSLYGAIGIAFFISFLWWFGVH

GQSVVNGVVTALLLSNLDANKAMLASANLSLENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVA

AFPAIFNVNEPVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFLVGGWQGVTTQLVI

LAMSTLVYFPFFKVQDRLAYQNEIKQSZ

MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALDSTTVNLLETDPYITSGRHLVVPKDAPNQKVTASLP

VAHELESLQRDILACRRVWMSZ

MKKRYLVLTALLALSLAACSQEKTKNEDGETKTEQTAKADGTVGSKSQGAAQKKAEVVNKGDYYSIQGKYDEIIVAN

KHYPLSKDYNPGENPTAKAELVKLIKAMQEAGFPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYSEHQT

GLAFDVIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEIAASGLSLEEYYGF

EGGDYVDZ

MREPDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQKELEIELILAHVNHKQRIESDWEEKELRKLAAEAE

LPIYISNFSGEFSEARARNFRYDFFQEVMKKTGATALVTAHHADDQVETIFMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL

HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPELEKENPRFRDAILGIGNEILDYDLAIAELSNNINVEDLQQLFSYSES

TQRVLLQTYLNRFPDLNLTKAQFAEVQQILKSKSQYRHPIKNGYELIKEYQQFQICKISPQADEKEDELVLHYQNQVAY

QGYLFSFGLPLEGELIQQIPVSRETSIHIRHRKTGDVLIKNGHRKKLRRLFIDLKIPMEKRNSALIIEQFGEIVSILGIATNNL

SKKTKNDIMNTVLYIEKIDRZ

MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIYFREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQIT

EWRLNKQGIPVFKLSNHQFIAADKRFLYDQSEVTPTIKKVWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEGRE

FLHIDQAGWVAKESTSEEDNRMSKVQEMLSEKYQKDSFSIYVKQLTTGKEAGINQDEKMYAASVLKLSYLYYTQEKIN

EGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKEDNKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSA

IMGDDWDPKEKLISSKMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYADSPFIL

SIFTKNSDYDTISKIAKDVYEVLKZ

MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYTELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSK

EETGIQFFTPSVTKVEKFTSTILPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGGG

NGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGARIPAGVLLEGPPGTGKTLLAKA

VAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAKKAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDG

FEGNEGIIVIAATNRSDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFVGADLEN

VLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHEAGHTIVGLVLSNARVVHKVTIVPRGRA

GGYMIALPKEDQMLLSKEDMKEQLAGLMGGRVAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEG

NHAMLGAQSPQKSISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYETGKMPEAVE

EESHALSYDEVKSKMNDEKZ

MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGNSQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENP

SQDKVEGIRDLFLTILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARK?DSQW

VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTVYSSSSKMEAMKPYIDTGQG

YTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQLLWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIAS

GAQNLRAKEVGAYELREVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQR

VVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINENVAFDNLVLPKLVLQPLVENALYHGI

KEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQDAGDSSQSQLKRGGVGLQNVDQRLKLHFGANYHMKIDSRPQKGTKV

EIYINRIETSZ

MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGNSQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENP

SQDKVEGIRDLFLTILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW

VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTVYSSSSKMEAMKPYIDTGQG

YTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQLLWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIAS

GAQNLRAKEVGAYELREVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQR

VVQVTKSLATYFRLALNQGKDLICLSDEINHIVRQYLFIQKQRYGDKLEYEINENVAFDNLVLPKLVLQPLVENALYHGI

KEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQDAGDSSQSQLKRGGVGLQNVDQRLKLHFGANYHMKIDSRPQKGTKV

EIYINRIETSZ

MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANSLNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASI

VVQLLQMDILPKFVEWGKQGEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTAGSMI

VTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSIIFVIILIITVLLIIYFTTYVQQAEYKIPIQYTK

VAQGAPSSSYLPLKVNPAGVIPVIFASSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTF

VQINPEKAAETYKRVVPISMEFVLYKVQKNICLNFFVVLQLLVPSSLVZ

MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPDINRAAEKIYQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIG

AATDATDYVVLAKALDKAAKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTAVAD

MGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGVVKRALEKVRGQSFDVVAETVKK

TAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPAVGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMAC

NQVGGLSGAFIPVSEDEGMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKTTAVRII

PKGKEG?DMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKNZ

MTQIIDGKALAAKLQGQLAEKTAKLKEETGLVPGLVVILVGDNPASQVYVRNKERSALAAGFRSSEVVRVPETITQEELL

DLIAKYNQDPAWHGILVQLPLPKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEG

KNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLSKVAAKADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDEN

GKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQAALRTLDRKZ

MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISKTVGLNVPNMAKIGLGNIPRETPLKTVAAESNPTGY

ATKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIYDFGPRQMETGELII

YTSADPVLQIAAHEDIIPLDELYRICEYARSTTLERPALLGRIIARPYVGEPGNFTRTANRRDLAVSPFFPTVLDKLNEAGI

DTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTLLKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDE

RLPEIIAAMRENDLLLITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETAMIGESFL

DKLVZ

MFISISAGIVTFLLTLVEIPAFIQFYRKAQITGQQMHEDVKQHQAKAGTPTMGGLVFLITSVLVAFFFALFSSQFSNNVGM

ILFILVLYGLVGFLDDFLKVFRKINEGLNPKQKLALQLLGGVIFYLFYERGGDILSVFGYPVHLGFFYIFFALFWLVGFSN

AVNLTDGVDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLGFFIFNHKPAKVFMGDVGSLALGGMLAAISMA

LHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKRIFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLT

LAILYLMZ

LFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLLAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLA

YHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFL

SNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVVIIA

LVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVP

LTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVLGWGLPGIW

AGSLLDNGFRWLFLRYRYQRYMSLKGZ

MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVA

FQSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLLLA

AITVLIILLINIFTKGFIKSISILIGLWGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIVMMCIIATVSMVEST

GVYLALSDITKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGA

LAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNGIVVASL

LAIVLNAVLNHKKKZ

MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEIKKKHEITLKGIFHAHKNGFG

FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKN

QKISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVP

DAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLEFGVHIADVSYYVTEGSALDKEALNRATSVYVTD

RVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIE

LMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHE

EPKAEKVQKFIDYASSFGLAIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYT

HFTSPIRAYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIV

KFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQS

SRSGRGRDSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTKZ

MGTTGFTIIDLIILIVYLLAVLVAGIYFSKKEMKGKEFFKGDGSVPWYVTSVSIFATMLSPISFLGLAGSSYAGSWILWFA

QLGMVVAIPLTIRFILPIFARIDIDTAYDYLDKRNSKALRIISALLFIIYQLGRMSIIMYLPSAGLSVLTGIDINILIILMGVV

AIVYSYTGGLKSVLWTDFIQGVILISGVVLALFVLIANIKGGFGAVAETLANGKFLAANEKLFDPNLLSNSIFLIVMGSGF

TILSSYASSQDLVQRFTTTQNIKKLNKMLFTNGVLSLATATVFYLIGTGLYVFYQVQNADSAASNIPQDQIFMYFIAYQL

PVGITGLILAAIYAASQSTISTGLNSVATSWTLDIQDVISKNMSDNRRTKIAQFVSLAVGLFSIGVSIVMAHSDIKSAYEWF

NSFMGLVLGLLGGVFILGFVSKKANKQGAYAALIVSTIVMVFIKYFLPPTAVSYWAYSLISISVSVVSGYIVSVLTGNKVS

APKYTTIHDITEIKADSSWEVRHZ

MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDGSQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYV

TSHGDHYHYYNGKVPYDALFSEELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQK

QEHVKDNEKVNSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLSASELAAAKAHLAGKNM

QPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELYDSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHF

IPYSKLSALEEKIARMVPISGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAYIVRHGD

HFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRIIAEDESGFVMSHGDHNHYFFKKDLTEEQIK

VRKNIZ

MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHK

HMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGNZ

MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDTVKGFAYTDMKQKLRLTTLEVTATQDQFGWGRVT

EVRKDLGVFVDTGLPDKEIVVSLDILPELKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQN

WPAIVYRLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSFEMLENDAQMILTYLE

SNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQDQFGTELIZ

MKDVSLFLLKKVFKSRLNWIVLALFVSVLGVTFYLNSQTANSHSLESRLESRIAANERAINENEEKLSQMSDTSSEEYQF

AKNNLDVQKNLLTRKTEILTLLKEGRWKEAYYLQWQDEEKNYEFVSNDPTASPGLKMGVDRERKIYQALYPLNIKAH

TLEFPTHGIDQIVWILEVIIPSLFVVAIIFMLTQLFAERYQNHLDTAHLYPVSKVTFAISSLGVGVGYVTVLFIGICGFSFLV

GSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFPGLLLAFLAFIVIVEVVYLLAYFFKQKMPVLFLSLIGIVGLLFGIQTIQP

LQRIAHLIPFTYLRSVEILSGRLPKQIDNVDLNWSMGMVLLPCLIIFLLLGILFIERWGSSQKKEFFNRFZ

MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVGFLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAI

VAVALTTYGSATAMIMFAGMVFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSISPAF

VQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRDSTVSITLSMAVIYIIVAIFAGSEYIEK

EISSGTSGLVYALQLAGQFAAGVFVILAGVRLILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFVGGLVS

MVIMIASGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGLGFQGSTFSDADFGLSGII

LGMLNQFGSQAGIVIGLVLILAVMFGVS?FIKKPSATEEZ

MIKTFLSALSVILFSIPIITYSFFPSSNLNIWLSTQPILAQIYAFPLATATMAAILSFLFFFLSFYKKNKQIRFYSGILLLLSLIL

LLFGTDKTLSSASNKTKTLKLVTWNV?ANQIEAQHIERIFSHFDADMAIFPELATNIRGEQENQRIKLLFHQVGLSMANYD

IFTSPPTNSGIAPVTVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQNIPDIIALHTAPPLPGLMEIWKQDLNIIHNQLASKYP

KAIIAGDFNATMRHGALAKISSHRDALNALPPFERGTWNSQSPKLFNATIDHILLPKNHYYVKDLDIVSFQNSDHRCIFT

EITFZ

MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKTVESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGL

ENVSPELETVAKLKDKEAVTGEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEEL

AKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFTDYESSQTLLGNSEAQVSAARFYVE

NPKEMDGLMKQVENLALENQGYQVEKENKAFEQIKDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGIL

LALGKGKSSIFLQFCLEVVLVSLGALLPAEVAGNAITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAESYVFLVLLS

CLSVALCFLFLFRKSPKEILSSISZ

MLHNAFAYVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKASQETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKI

TENKAIESYVKRINAIGDLTGYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDKDK

ILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTYSQELYENTAITDIHTAAKLYGY

TEDTAIYGDATFFVTADKNLDDVMKELNGISGINWKSYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALL

LSLWINARRKEVGILLSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASKAAQASNLGG

GAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQPKELLLDGEZ

MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQSKETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSV

AGVFIYGHIIGTIYNYIGIVIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIDWLDKGNRFDRFFIFMMIWPISPADFLCMLA

ALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQMLZ

MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGSSMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDE

ASAKEAIKEEKLKGYLTIDQEDSVLKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDE

AKENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYARMMALFLVILTHIGIYVVGGL

AAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISLFMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAA

GDNLLLKIGSYIPFISTFFMPFRTINDYAGGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTFKRALSYKZ

MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQSYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFV

GDLNRAEKGARLHTDTFQPQGVEGLLISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFG

MALGVPNQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQFGQAEPSSTRKNLEQK

KLLZMLKLIAIVGTNSKRSTNRQLLQYMQKHFTDKAEIELVEIKAIPVFNKPADKQVPAEILEIAAKIEEADGVIIGTPEYD

HSIPAVLMSALAWLSYGIYPLLNKPIMTTGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDL

DVIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENLZ

MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNS

QQTYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDAL

LETATIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLP

LPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVDDVDFZ

MRCKMLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPDDILDFILVAFPLAILGARLYYVIFRFDYYSQNLG

EIFAIWNGGLAIYGGLITGALVLYIFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQ

MYIEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMRTDSLMFFGFRVSQWLSVVLI

GLGIMIVIYQNRKKAPYYITEEENZ

MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDPEYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEIT

VDSILAQTKSYAFQATEASKNQLNNLKEQWQEKAEALDDSEEIVIDITEEZ

MKTKLIFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVYLKPETIQYNFHILMNYLTNPFSQVLQMPDFRSSAAG

LHHFAVVKNLFHLVQLVALVTLPSFYVFVNRIVKKDFLSLYRKSLLALVVLPVMIGLGGVLIGFDQFFTLFHQILFVGD

DTWLFDPAKDPVIMILPETFFLHAFLLFFALYENFFGYLYLKSRRKZ

MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKT

YIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVT

TGTALRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTEIQPGDEVPNHFSYTSRDEDY

VKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLST

SLPEDVQRDLVHSIKGLENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGINAAL

KIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMRLTEMGREIGLVDDERWARFEIKKNQF

DNEMKRLDSIKLKPVKETNAKVEEMGFKPLTDAVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISK

AMDQVAKMKRMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEGKNRSISKTLQKSKZ

MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIM

MVSAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKA

NKLLSLTPKEFESDKNPFFEVFKVSKVTAQZ

MTTFKDGFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVAREITLGVLEGKYYPNHEAIDFYHRYKEDIALF

AEMGFKCFRTSIAWTRIFPKGDELEPNEEGLQFYDNLFDECLKNGIEPVITLSHFEMPYHLVTEYGGWKNRKLIDFFARF

AEVVFKRYKDKVKYWMTFNEINNQANYQEDFAPFTNSGIVYEEGDNREAIMYQAAHYELVASARAVKIGHEINPDFQI

GCMIAMCPIYPVTCNPKDILMAMKAMQKRYYFADVHVLGKYPEHIFKYWERKGISVDFTAQDKEDLLGGTVDYIGFS

YYMSFAIDSHRENNPYFDYLETEDLVKNNYVKASEWEWQIDPEGLRYALNWFTDHYHLPLFIVENGFGAIDQVAADG

MVHDDYRIEYLGAHIREMKKAVVEDGVDLMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDNGKGSYNRSPKKSFG

WYKEVISSNGESVEZ

MDQQNGLFGFLENHVMGPMGKLAQFKVVRAITAAGMAAVPFTIVGSMFLVFSILPQAFSFWPIVADIFSASFDKFTSLY

MVANYATMGSLSLYFVLSLAYELTKIYAEEEELNMNPLNGALLALMAFVMTVPQIIFDGGMMKTVTSLKEGAVIADG

WAMGNVVARFGTTGIFTAIIMAIVTVLIYRMCVKHNWVIKMPEAVPEGVSRGFTALVPGFVVAFVVIFINGLLVAMGT

DIFKVIAIPFGFVSNLTNSWIGLMIIYLLTQLLWIVGIHGANIVFAFVSPIALANMAENAAGGHFAVAGEFSNMFVIAGGS

GATLGLCLYIAFASKSEQLKAIGRASVVPALFNINEPLIFGLPIIYNPALAIPFILAPMVTATIYYVANSLNFIKPIIAQVPWP

TPVGIGAFLGTADLRAVLVALVCAFAAFLVYLPFIRVYDQKLVKEEQGIZ

MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVGGYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTALLEQ

MPVGVMKLNLSSGEVEWFNPYAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR

EQAITDELVTSRPVIGIVSVDNYDDLEDETSESDISQINSFVANFISEFSEKHMMFSRRVSMDRFYLFTDYTVLEGLMNDK

FSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIGKVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRT

RTRTRAMMTAISDKIRSVDQVFVVGHKNLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFIEKEGVTK

LLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQTIVIDHHRRDQDFPDNAVITYIESGASSASELVTELIQFQNS

KKNRLSRMQASVLMAGMMLDTKNFTSRVTSRTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGRKLGSDVLI

AEAKDMKCYDTVVISKAADAMLAMSGIEASFVLAKNTQGFISISARSRSKLNVQRIMEELGGGGHFNLAAAQIKDVTLS

EAGEKLTEIVLNEMKEKEKEEZ

MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVALLQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFF

RAKDLARLGLSYLVIVGSNILGSILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKENL

GFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAFCLLALVVIMSRTLGISVZ

MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVALLQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFF

RAKDLARLGLSYLVIVGSNILGSILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKENL

GFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAFCLLALVVIMSRTLGISVZ

MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGLGQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHF

LPFYGRAHLAYIPDGRVAGLSKLARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPGT

ATLTTVARGLFETDKDLRDQAYRLMGLZMKDLFLKRKQAFRKECLGYLRYVLNDHFVLFLLVLLGFLAYQYSQLLQH

FPENHWPILLFVGITSVLLLLWGGTATYMEAPDKLFLLVGEEEIKLHLKRQTGISLVFWLFVQTLFLLLFAPLFLAMGY

GLPVFLLYVLLLGVGKYFHFCQKASKFFTETGLDWDYVISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKAV

QKVPGKIWQNLYLRSYLRNGDLFALSLRLLLLSLLAQVFIEQAWIATAVVVLFNYLLLFQLLALYHAFDYQYLTQLFPL

DKGQKEKGLQEVVRGLTSFVLLVELVVGLITFQEKLALLALLGAGLVLLVLYLPYQVKRQMQDZ

MRKSIVLAADNAYLIPLETTIKSVLYHNRDVDFYILNSDIAPEWFKLLGRKMEVVNSTIRSVHIDKELFESYKTGPHINYA

SYFRFFATEVVESDRVLYLDSDIIVTGELATLFEIDLKGYSIGAVDDVYAYEGRKSGFNTGMLLMDVAKWKEHSIVNSL

LELAAEQNQVVHLGDQSILNIYFEDNWLALDKTYNYMVGIDIYHLAQECERLDDNPPTIVHYASHDKPWNTYSISRLRE

LWWVYRDLDWSEIAFQRSDLNYFERSNQSKKQVMLVTWSADIKHLEYLVQRLPDWHFHLAAPCDCSEELTSLSQYTN

VTVYQNVLHSRIDWLLDDSIVYLDINTGG?EVFNVVTRAQESGKKIFAFDITRKSMDDGLYDGIFSVERPDDLVDRMKNI

EIEZ

MTKIYSSIAVKKGLFTSFLLFIYVLGSRIILPFVDLNTKDFLGGSTAYLAFSAALTGGNLRSLSIFSVGLSPWMSAMILWQ

MFSFSKRLGLTSTSIEIQDRRKMYLTLLIAVIQSLAVSLRLPVQSSYSAILVVLMNTILLIAGTFFLVWLSDLNASMGIGGSI

VILLSSMVLNIPQDVLETFQTVHIPTGIIVLLALLTLVFSYLLALMYRARYLVPVNKIGLHNRFKRYSYLEIMLNPAGGMP

YMYVMSFLSVPAYLFILLGFIFPNHSGLAALSKEFMVGKPLWVYVYISVLFLFSIIFAFVTMNGEEIADRMKKSGEYIYGI

YPGADTSRFINRLVLRFSVIGGLFNVIMAGGPMLFVLFDEKLLRLAMIPGLFMMFGGMIFTIRDEVKALRLNETYRPLIZ

MSSLSDQELVAKTVEFRQRLSEGESLDDILVEAFAVVREADKRILGMFPYDVQVMGAIVMHYGNVAEMNTGEGKTLT

ATMPVYLNAFSGEGVMVVTPNEYLSKRDAEEMGQVYRFLGLTIGVPFTEDPKKEMKAEEKKLIYASDIIYTTNSNLGFD

YLNDNLASNEEGKFLRPFNYVIIDEIDDILLDSAQTPLIIAGSPRVQSNYYAIIDTLVTTLVEGEDYIFKEEKEEVWLTTKG

AKSAENFLGIDNYKEEHASFARHLVYAIRAHKLFTKDKDYIIRGNEMVLVDKGTGRLMEMTKLQGGLHQAIEAKEHV

KLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRIPTNRPRQRIDYPDNLYITLPEKVYASLEYIKQ

YHAKGNPLLVFVGSVEMSQLYSSLLFREGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRGTDIKLGKGVAEL

GGLIVIGTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDMTQPEVLKGRKYRKL

VEKAQHASDSAGRSARRQTLEYAESMNIQRDIVYKERNRLIDGSRDLEDVVVDIIERYTEEVAADHYASRELLFHFIVTN

ISFHVKEVPDYIDVTDKTAVRSFMKQVIDKELSEKKELLNQHDLYEQFLRLSLLKAIDDNWVEQVDYLQQLSMAIGGQS

ASQKNPIVEYYQEAYAGFEAMKEQIHADMVRNLLMGLVEVTPKGEIVTHFPZ

MIGTFAAALVAVLANFIVPIEITPNSANTEIAPPDGIGQVLSNLLLKLVDNPVNALLTANYIRILSWAVIFGIAMREASKNS

QELLKTIADVTSKIVEWIINLAPFGILGLVFKTISDKGVGSLANYGILLVLLVTTMLFVAPVVNPLIAFFFMRRNPYPLVW

NCLRVSGVTAFFTRSSATNIPVNMKLCHDLGLNPDTYSVSIPLGSTINMAGVAITINLLTLAAVNTLGIPVDFATAFVLSV

VAAISSCDASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIGVIQDSCETALNSSTDVLFTAVAEYAATRKKZ

MSISQRTTKLILATCLACLLAYFLNISSAVSAGIIALLSLSDTRRSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLY

LAFYVPLAYKMGWEIGITPSTVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLKDI

LQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMRQRQSRILRNMAQQINTCHLAAS

ESLILAQLFSKIAGQLSQTNPASDLLDEIERYLEVFRNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYRQZ

MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQEATNLRG?QAEREADLLVNEAKRESKSLKKEALLEAK

EEARKYREEVDAEFKSERQELKQIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE

LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRIAGEYVAESTNSTVHLPDDTMKG

RIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFDPIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEA

AAYEIGAPNLHPDLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAIDHEVEGSHVE

IGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGARSESLESYIKRLHDLEEIANGFEGVQTSFAL

QAGREIRIMVNPGKIKDDKVTILAHKVRKKIENNLDYPGNIKVTVIRELRAVDYAKZ

MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSEKSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKR

RKEEEEKKIKEQIAKEKEDGEKIZ

MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQLYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKI

AIMDGDQFGSDFVKLNPNSKIPALLDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLG

GGFGHFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADLAIWSWYGQLVQGNLYQGSAKFLDASS

YQNLVKWAEKIANRPAVKRGLEVTYTEIKZ

LASLITSIIMFYVGFDVLRDTIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSNALKAAAKDNLSDAVTSL

GTALAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLEDYQKAIMEIPKISKVKSQRGRTYGSNIYLDIT

LEMNPDLSVFESHEIADQVESMLEERFGVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQ

DGEQMDKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETKKEZ

MTIKLVATDMDGTFLDGNGRFDMDRLKSLLVSYKEKGIYFAVASGRGFLSLEKLFAGVRDDIIFIAENGSLVEYQGQDL

YEATMSRDFYLATFEKLKTSPYVDINKLLLTGKKGSYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEE

TLEDGEAWVNENVPGVKAMTTGFESIDIVLDYVDKGVAIVELVKKLGITMDQVMAFGDNLNDLHMMQVVGHPVAPE

NARPEILELAKTVIGHHKERSVIAYMEGLZ

MADIKLIALDLDGTLLTTDKRLTDRTKETLQAARDRGIKVVLTTGRPLKAMDFFLHELGTDGQEDEYTITFNGGLVQK

NTGEILDKTVFSYDDVARLYEETEKLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFA

QEPLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGIDQSQVMACGDEANDLSMIEWAGLGVAM

QNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKENZ

MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQLDYRFDQARQASQLDQKDLEVVVSDRLQEVRIELH

QGLTQVRQEMTDNLLQTRDKTDQRLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQ

TVARDVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPGQGDQEYVYLPIDSKFPLA

DYYRLEEAYETGDKDEIERCRKSLLASVKRFARDIRNKYLAPPRTTNFGVLFVPTEGLYSEIVRNPVFFDDLRREEQIIVA

GPSTLSALLNSLSVGFKTLNIQKSADHISKTLASVKTEFGKFGGILVKAQKHLQHASGNIDELLNRRTLAIERTLRHIELSE

GEPALDLLHFQENEEEYEDZ

MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEIDGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNT

PQVNQITLRLPQAGEPNDPADFKVKSPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFET

GLAYHTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIALIDSEITKTVMELGIDDT

KEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNLDASMMMMSTALALVDKGEMTNKIFAMDNRSFYKPDLDZ

MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYETQPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAID

VAFFILMVGGFLGIVNKTGALDVGIASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS

LTGVAIILLGSQIGCLASSTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFVYRYADKIQKDPTKSLVYSTRKED

LKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMVLSFIPWTDLGVTIFDDFNTWLTGLPVIGNIVGSSTSALGTWYFPEG

AMLFAFMGILIGVIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGLSSQVFIVVTYIF

YLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGVLNLLAPTSGIVMGALALGRINIGTWWKFMGKLVVA

IIVVTIALLLLGTFLPFLZ

MSNSFVKLLVSQLFANLADIFFRVTIIANIYIISKSVIATSLVPILIGISSFVASLLVPLVTKRLALNRVLSLSQFGKTILLAIL

VGMFTVMQSVAPLVTYLFVVAISILDGFAAPVSYAIVPRYATDLGKANSALSMTGEAVQLIGWGLGGLLFATIGLLPTT

CINLVLYIISSFLMLFLPNAEVEVLESETNLEILLKGWKLVARNPRLRLFVSANLLEIFSNTIWVSSIILVFVTELLNKTESY

WGYSNTAYSIGIIISGLIAFRLSEKFLAAKWEPQLFTPNLKTIQNPCLSLDPGWFLFSPNGCFLLDKKEFPLYGISVEKNTK

RKETHMNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKERISKYLVTNDQRRYCRYSDSDILVQFLFQLL

TGYGTDYACKELSADAYFPKLLEGGQLASQPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTY

GKQEGVAYNAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSGFATPKLYDLIE

KTGQYYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAGSWSHKRRVCQFSERKEGNLFYDVISLVTNMTS

GTSQDQFQLYRGRGQAENFIKEMKEGFFGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFL

HVVGKCVRTGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMHZ

MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYEVLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLF

YKHYRKSKDGKWVFYLVSFLSLLPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIVIELRDGVIKDFTLWEFLRFLLFMPT

FSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMWGFLYKFILAHVLGETLLPPLKNLALQSGGFFNLYALAVMYT

FGLELFFDFAGYSMFALAISNLMGIRSPINFNKPFLSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRN

VTSSMAYIVNMLIMGFWHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVTFH

VVMLSFLIFSGFLNNLWFKKZ

MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVATTIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFD

GAHPAVLAEKYNRSYRPYLLGQGGAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTS

FLKHQSGDQASQYAATRLLQQFPNVAMKDLVQKLASKEELSTADNEMIELLARFNERQASFFGQFSVRGYVNYDKHV

AKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQIKKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSK

SKVNPIFIIPPVNKKWMNYAGLREDMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVD

PFLSNPTPAPTYHLNERFFSKDWATYDGDVKEFQZ

MEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTG

KMTQAEYKAYYTKGYHTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYV

QFSDHNVAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYPDNLSGQEIAQEMLAHZ

MKDGHLLAHHIRLLNGRIFQKLLSQDPEALYRGEQGKILAVLWNSETGCATATDIALATGLANNTLTTMIKKLEEQKL

VIVSPCGKDKRKKYLVLTELGKSQKEVGHRVSQKLDTIFYKGFSEEEIHQFEGFQERILANLKEKGNEVZ

MTNLIATFQDRFSDWLTALSQHLQLSLLTLLLAILLAIPLAVFLRYHEKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTL

PALTALVIYAIFPILQNTITGLKGIDPNLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLAALIGAGGL

GSFILLGIDRNNASLILIGALSSAVLALAFNFLLKVMEKAKLRTIFSGFALVALLLGLSYSPALLVQKEKENLVIAGKIGPEP

EILANMYKLLIEENTSMTATVKPNFGKTSFLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQD

HLAYLKPMSYQNTYAVAVPKKIAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGLNLNVATIEPALRY

QAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMKEALLKKHPELERVLNTLAGKITESQMSQLNYQVG

VEGKSAKQVAKEFLQEQGLLKKZ

MMHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWDDLFAHRSFAQWIYLLVLGSFPLWLELVYEHRI

VDWIGMICSLTGIICVIFVSEGRASNYLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQFKKEKQEFV

ARKLDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITDATNGVGQILMTAVYREQWIFWAATNVFSIYLWWGES

LQIQGKYLIYLINSLVGWYQWSIKAAKQNTDLLNZ

MRNMKAKYAVWVAFFLNLTYAIVEFLAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNREEDNQYTLGYKRFSLLG

ALVTAVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAI

VLRFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIV

HVCLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQHZ

MIEYKNVALRYTEKDVLRDVNLQIEDGEFMVLVGPSGSGKTTMLKMINRLLEPTDGNIYMDGKRIKDYDERELRLSTG

YVLQAIALFPNLTVAENIALIPEMKGWSKEEITKKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKIFL

MDEPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVANPETILKAPATDFVADLFG

GSVHDZ

MSAVAISAMTKVMQETHGNPSSIHGHGRQAGKLLREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKH

IITTAIEHHAVLETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFVNNETGNLLPIAEIGQILKQHPAAYH

VDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFDSYLHGGDQEQKKRAGTENLPAIVGMVAALKEDL

EKQEEHFQHVQNLETAFLAELEGIQYYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLE

AMYGANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGGZ

MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQVESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWG

QIICLLLIQIGGLGLMTFIGVFYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQLGWGR

GLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVWFDLAGHVGRKKKGRLHFHTKLVLLLTI

GLLLFGTATTLFLEWNNAGTIGNLPVADKVLVSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLK

ITTFFVLLVFARSELLGLPHANVARRTIAPRTVQKSFSVFIIFLMSFLIGLILLGITAKGNPPFIHLVFETISALSTVGVTANL

TPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYHPEKKDMIHYMKADISIGZ

MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEPVLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESS

VLAVMHCKSLGVPTVLAKVKSQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWAG

QSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVALNSZ

MKLLSIAISSYNAAAYLHYCVESLVIGGEQVGILIINDGSQDQTQEIAECLASKYPNIVRAIYQENKCHGGAVNRGLVEAS

GRYFKVVDSDDWVDPRAYLKILETLQELESKGQEVDVFVTNFVYEKEGQSRKKSMSYDSVLPVRQIFGWDQVGNFSK

GQYTMMHSLIYRTDLLRASQFZ

MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADGLNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKP

EGVTGNTNSLPTPTERTEVSEETSPSSLDTLFEKDEEAQKNPELTDVLKETVDTADVDGTQASPAETTPEQVKGGVKEN

TKDSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAKNPALPPLEGLTKGKYFYE

VDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGKADLTNLVATKNVDININGLVAKETVQKAVADNVKDS

IDVPAAYLEKAKGEGPFTAGVNHVIPYELFAGDGMLTRLLLKASDKAPWSDNGDAKNPALSPLGENVKTKGQYFYQV

ALDGNVAGKEKQALIDQFRANGTQTYSATVNVYGNKDGKPDLDNIVATKKVTININGLISKETVQKAVADNVKDSIDV

PAAYLEKAKGEGPFTAGVNHVIPYELFAGDGMLTRLLLKASDKAPWSDNGDAKNPALSPLGENVKTKGQYFYQLALD

GNVAGKEKQALIDQFRANGTQTYSATVNVYGNKDGKPDLDNIVATKKVTININGLISKETVQKAVADNVKTVSMFQQP

TZ

MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFP

SNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLATIG

RQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSRILVN

LVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGG

EITVSSQYGLGSTFTLVLNLSGSENKAZ

MFGQTAQHGLTNSLKDFWIFLLNIGPQLAFFCQMLRCSRSVEQGTGNHRREFNMIQQIFSHFGMTHLGQIKLVYQESID

LELLVNALNHHLLIDRLVLTPNQITIEIDRQIVHGLDLLKGRKDKEIIDIKSMFRQLELASTQQICPINQRVHHGILAFGEIS

DLVPAKNLPNRQDZ

MEHLATYFSTYGGAFFAALGIVLAVGLSGMGSAYGVGKAGQSAAALLKEQPEKFASALILQLLPGTQGLYGFVIGILIW

LQLTPELPLEKGVAYFFVALPLAIVGYFSAKHQGNVAVAGMQILAKRPKEFMKGAILAAMVETYAILAFVVSFILTLRVZ

MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPNTVFAGFYLFDGKELVLGPFQGGVSCIRIALGKGVC

GEAAHFQETVIVGDVTTYLNYISCDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDAMDRDYLEQFVAILLEKTAWD

FTMFEEKSZ

MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKSTLSAAIMGNPNYEVTKGEVLFDGVNILELEVDERAR

MGLFLAMQYPSEIPGITNAEFLRAAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEIL

QLLMLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHVMMEGRVVLSGGPELAAR

LEREGYAKLAEELGYDYKEELZ

MPYKRQRSFSMALSKLDSLYMAVVADHSKNPHHQGKLEDAEQISLNNPTCGDVINLSVKFDAEDRLEDIAFLNSGCTIS

TASASMMTDAVLGKTKQEILELATIFSEMVQGQKDERQDQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQZ

MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTDHGYVTDFETFKEGILAREALTSTGLGDGIAMPHSKNAAVKEATV

LFAKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEEL

VQAPANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEM

DRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMI

ALAFLIDGALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAGYVAYSLAEKPGLVAGFVAGAIAKEGFAFGKIP

YAAGGEATSTLAGVSSGFLGALVGGFLAGALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAM

NDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAYVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLF

KDKFTKEERNSGLTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNALLYLVS

VLVGAIVSGVVYGYLRKPQAZ

MANKNTSTTRRRPSKAELERKEAIQRMLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGLLIYLFFFKWIRK

QEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLTGFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGS

ILILVGSLLVSPWSVYDIAEFFSRGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPPVDMETGE

ILTEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAKEALEYKLPSLQLFAPDKPKDQSKEKKIVRE

NIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATV

SFRELWEQSQTKAENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQVKFMMVDPK

MVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFAKVGVRNIAGFNAKVEEFNSQSEYKQIPLPFIVVIVDE

LADLMMVASKEVEDAIIRLGQKARAAGIHMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRG

DMLFKPIDENHPVRLQGSFISDDDVERIVNFIKTQADADYDESFDPGEVSENEGEFSDGDAGGDPLFEEAKSLVIETQKA

SASMIQRRLSVGFNRATRLMEELEIAGVIGPAEGTKPRKVLQQZ

MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQIGALTAVFSLRESFDESVHFGTSRILGNSIGGLYALV

FFLLNTFFHEAFWVTLVVVPICTMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETILYVFVRVLETFMGVFVAIIVN

YDIDRIRLFLEKKEKZ

MNKSEHRHQLIRALITKNKIHTQAELQALLAENDIQVTQATLSRDIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELY

MEDALVWMRPVQHQVLLKTLPCLAQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEEZ

MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSVDTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRT

FSSLFYLCIACTILTTAVYILAYPLFFTDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIFLFVK

NEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVFANANMLFTFLDRLFLVKTGIDVNVSY

YTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGKGDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGIL

TSLFAFRTIILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVAPEYYLLTTMLSETSLLVFYIIFIHRKQL

IHLGHIFSYTVRYSLFSLSFVAIYFLINFVYPVDMVINLPFLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKK

SZ

MELFMKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSIL

DDCYPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAAL

QNGGKTIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLTTCE

RAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEFZ

MKQLTVEDAKQIELEILDYIDTLCKKHNINNYIINYGTLIGAVRHEGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLS

LETDKNYFNNFIKITDSTTKIIDTRNTKTYESGIFIDIFPIDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKDWIRT

AFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKTIDLPFENLSLPAPEKFDTILTQFYGDY

MTLPPEEKRFYSHEFHAYKLEDZ

MIKINHLTITQNKDLRDLVSDLTMTIQDGEKVAIIGEEGNGKSTLLKILMGEALSDFTTKGNIQSDYQSLAYIPQKVPEDL

KKKTLHDYFFLDSIDLDYSILYRLAEELHFDSNRFASDQEIGNLSGGEALKIQLIHELAKKPFEILFLDEPSNDLDLETVDW

LKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLVEHLDYDSYSEQRKANFAKQSQQAANNQRAYDKT

MEKHRRVKQNVETALRATKDSTAGRLLAKKMKTVLSQEKRYEKAAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLE

KENLSIDDRVLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKLQRLLNDKREISLGFMPQDYHKKLQLDLSPIAYLSKTGE

KEELQKIQSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDLVLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVS

HDRRFLKEVCSIIYRMTEHGLKLVNLEDLZ

MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTATTDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGA

GFPSLPMKILYPELDVTIIDSLNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT

IPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKKKETPNKYPRKAGMPNKRPLZ

MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATGRPIAGVAKLLDDLQLRDEGDYVVTFNGALVQETATG

HEIISESLTYEDYLDMEFLSRKLGVHMHAITKDGIYTANRNIGKYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPEI

LDAAIEKIPAEFYERYSINKSAPFYLELLKKNVDKGSATTHLAEKLGLTKDETMAIGDEENDRAMLEVVGNPVVMENGN

PEIKKIAKYITKTNDESGVAHAIRTWVLZ

MTWIILGVIALIVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRRNDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAA

TSPAEAMKASDALTRQVSGIFAVAESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFP?NIIAGMF

GFKAADFLQTPEEEKSVPKVDFSGLGDZ

MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPD

LYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV

ALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELT

RNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQMZ

MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVGKVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVES

YPVTEVFMEGATNQLDQEVLDDDLVLPIENGELDLAESVSDNILLNIPIKVLTAEEEAGQGFISGNDWQIMTEEEYQAQ

KAVKKEENSPFAGLQGLFDGDEZ

MKRQLALVVFSGGQDSTTCLFWVMQHYETVEAVTFAYGQRHHLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATI

HISYIPDKLCVESKSLKLYLFSYRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNYGKQGTKYEGL

AEQRLFQHDLYPEKIDNRZ

MTETVEDKVSHSITGLDILKGIVAAGAVISGTVATQTKVFTNESAVLEKTVEKTDALATNDTVVLGTISTSNSASSTSLSA

SESASTSASESASTSASTSASTSASESASTSASTSISASSTVVGSQTAAATEATAKKVEEDRKKPASDYVASVTNVNLQSYA

KRRKRSVDSIEQLLASIKNAAVFSGNTIVNGAPAINASLNIAKSETKVYTGEGVDSVYRVPIYYKLKVTNDGSKLTFTYT

VTYVNPKTNDLGNISSMRPGYSIYNSGTSTQTMLTLGSDLGKPSGVKNYITDKNGRQVLSYNTSTMTTQGSGYTWGNG

AQMNGFFAKKGYGLTSSWTVPITGTDTSFTFTPYAARTDRIGINYFNGGGKVVESSTTSQSLSQSKSLSVSASQSASASAS

TSASASASTSASASASTSASASASTSASVSASTSASASASTSASASASTSASESASTSASASASTSASASASTSASASASTSASE

SASTSASASASTSASESASTSASASASTSASASASTSASGSASTSTSASASTSASASASTSASASASISASESASTSASESASTST

SASASTSASESASTSASASASTSASASASTSASASASTSASASTSASESASTSASASASTSASASASTSASSASASTSASASASTS

ASVSASTSASASASTSASASASTSASESASTSASASASTSASASASTSASASASTSASESASTSASASASTSASESASTSASASA

STSASASASTSASGSASTSTSASASTSASASASTSASASASISASESASTSASESASTSTSASASTSASESASTSASASASTSASA

SASTSASASARQVRRPQPVHLNRHQPVRQPQQVLVHQLQHQRVHRLQHQPVPRLQRQPVRQLQQVPVLQSQHQQVLQ

PQHRQVPRLQQAHQHLNQRRQAPQLQQVPVRQPQRRQVRQPQQVLVHQLQHQRVHRLRRQPVHQSQQVPVRQLPHQ

QVPRLQQAPVRRLQQVLAPQPQPQPVRQPQQVSQRLNRHQRVRPLQQVLAPQPQRQQVHRLQRQRVRLNRHQRVRPL

QQVLAPQPQRQQVHRLQHQRVRPLQQVLAPQPQRQQVHRLQRQRVRLSQHQRVRQPQQAHQLLNLHQPVRQPQHRQ

APQLQQVPVRQPQRRQVRRLQQVPVRQPQQVPVRQPQRRQVRRPQPVHLNRHQPVRQPQQVLVHQLQHQRVHRLQH

QPVHQSQQVPVRQFRINKCLGFSKYZ

MGVETWFYSSICWLAIGLGSVWKFPYMTAANGGGGFLLIFLISTILIGFPLLLAEFALGRSAGVSAIKTFGKLGKNINKYN

FIGWIGAFALFILLSFYSVIGGWILVYLGIEFGKLFQLGGTGDYAQLFTSIISNPAIALGAQAAFILLNIFIVSRGVQKGIERA

SKVMMPLLFIVFVFIIGRSLSLPNAMEGVLYFLKPDFSKLTSTGLLYALGQSFFALSLGVTVMLTYASYLDKKTNLVQSG

ISIVAMNISISIMAGLAIFQARSPFNIQSEGGPSLLFIVLPQLFDKMPFGTIFYVLFLLLFLFATVTFSVVMLEINVDNTTNQD

NSKRAKWSVILGILTFVFGIPSALSYGVMADVHIFGKTFFDAMDFLVS?NLLMPFGALYLSLFTGYIFKKALAMEELHLD

ERAWKQGLFQVWLFLLRFFVSSFQSSSLWSSLPNLCNQKGLEZ

MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQAFANEILFGLWCMAAPLAAIFVPRVGSATIGEVLAA

LAEVLYGSQFGLGALLSGFVQGLGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRFISV

YFFCTILVRAIVKLYHQFATGGKAZ

MVKVATQTPIISLFLLILSLETSFIPSIALTLSVVAFCILFMLYYRRFKMLAWMIILAILPSFANYWAVQLHGDASQAVML

GTRAFVTVCIGLVFVSSVSLKELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKVLM

TVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFLZ

MRKHQLQVHKLTILSMMIALDWLTPIFRIEGMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGAT

FGALLAGLFYKYGRKFHYSALGEILGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFLAFRFLIKQEFFK

KVQGYFFSERIDZ

MQEFTNPFPIGSSSLIHCITNEISCEMLANGILALGCKPVMADDSREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYAN

QSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYP

GMSFLVTGPKDLVVSKNQVAVLGNGCTELDWTTGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMG

LEEFRYQVLNQLSLLRRDENWLDTIKGEVYEZ

MNHKIAILSDVHGNATALEAVIADAKNQGASEYWLLGDIFLPGPGANDLVALLKDLPITASVRGNWDDRVLEALDGQ

YGLEDPQEVQLLRMTQYLMERMDPATIVWLRSLPLLEKKEIDGLRFSISHNLPDKNYGGDLLVENDTEKFDQLLDAET

DVAVYGHVHKQLLRYGSQGQQIINPGSIGMPYFNWEALKNHRSQYAVIEVEDGELLNIQFRKVAYDYEAELELAKSKG

LPFIEMYEELRRDDNYQGHNLELLASLIEKHGYVEDVKNFFDFLZ

MNVNQIVRIIPTLKANNRKLNETFYIETLGMKALLEESAFLSLGDQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVE

NPLEIEGILSKTDSIHRLYKGQNGYAFEIFSPEDDLILIHAEDDIASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDIESF

LESSEIGASLDFIPAQCQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFFSTEYFIPKSEKFFLGKDRNNVELWFEEVZ

MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSDPEHGLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLD

IDRLVIDFLPESDYPDTTIRQLLTHATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDLD

VILKDQVWKPWGMTETKFGPVELAVPTVRGVEAGIVHDPKARLLGRHAGSAGLFSTIKDLQIFLEHYLADDFARDLNQ

NFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQKQEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEEZ

MMKKTYNHILVWGVIFYSICIVCFCFTPQEQSTVGVGTPGIQHLGRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNILNV

FLFFPLIFQLLYLFPNLRKTKKVLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKVRN

Z

MKIPLLTFARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDLAKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIII

VLLGFQYIELKNKVLRLSIGREVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIITYFFGTFSPLGWNSLFSDGSGLQRLLDGE

IKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAITYLMFLWLGSMLLYSALPYYMVPMTSLMQASYGDVSLMKLFTP

YILYIVPYMVLEKYEDNVZ

MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPILDNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKR

DKGTAALAGVTGYLVMTATIKALVKLFMAEGSAIDTGVIGALVVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTSF

SSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPMFWYTELGGVETVAGQTVVGAQKIF

FAQLADLAHSGLFTEGTRFFAGRFSTMMFGLPAACLAMYHSVPKNRRKKYAGLFFGVALTSFITGTTEPIEFMFLFVSPV

LYVVHAFLDGVSFFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPFGLIWSVLYYIIFRWFTTQFNVLTPGRGE

EVDSKEISESADSTSNTADYLKQDSLQIIRALGGSNNIEDVDACVTRLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQ

AIYGAKAILYKNSINEILGVDDZ

MKFRKLACTVLAGAAVLGLAACGNSGGSKDAAKSGGDGAKTEITWWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDI

KVKLETIDFKSGPEKITTAIEAGTAPDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPI

SSAPFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGTRAFISNLYSGSVTDEKV

SKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNFANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSD

EGKPALEYLVNGFAVFNNKDDKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP

YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQZ

MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFI

SLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM

KQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRNNLTISLGVATMQAEMA

TNYGLIMAGAALAAVPIVTVFLVFQKSFTQGTTMGAVKGZ

MKIMFKNFNNILLNRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFFKRELISIFSYNDYSEANLEIPKLLLNLSLFMVGW

LSVILLESDLADHYHHLIRYQSSSFFDYTRKRLVVISKFFTQDLFVWFLGLLPLGIHFKTVALFFLLAQLMMLYLLLSYLI

ALISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLVLLSLLVMLIVSRLEEKFKKGZ

MGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKGSIESMHNLPVNLAG

ARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKKDYTYKAPLAQQALPETGNKESDLLASLG

LTAFFLGLFTLGKKREQZ

MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEFRQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKI

QAAKNGAELADVTSEVTEEADGYTVRVYNPGQEGDIVEVDLVWNLKNLLFLYDDLAELNWQPLTDSSESIEKFEFHVR

GDKGAEKLFFHTGKLFREGTIEKSNLDYTIRLDNLPAKRGVELHAYWPRTDFASARDQGLKG?NRLEEFNKIEDSIVREK

DQSKQLVTWVLPSILSISLLLSVCFYFIYRRKTTPSVKYAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTF

DQLIQATLLDVIDRGNVSIISEGDAVGLRLVKEDGLSSFEKDCLNLAFSGKKEETLSNLFADYKVSDSLYRRAKVSDEKR

IQARGLQLKSSFEEVLNQMQEGVRKRVSFWGLPDYYRPLTGGEKALQVGMGALTILPLFIGFGLFLYSLDVHGYLYLPL

PILGFLGLVLSVFYYWKLRLDNRDGVLNEAGAEVYYLWTSFENMLREIARLDQAELESIVVWNRLLVYATLFGYADK

VSHLMKVHQIQVENPDINLYVAYGWHSTFYHSTAQMSHYASVANTASSTYSVSSGSGSSGGGFSGGGGGGSIGAFZ

MKKVRKIFQKAVAGLCCISQLTAFSSIVALAETPETSPAIGKVVIKETGEGGALLGDAVFELKNNTDGTTVSQRTEAQTG

EAIFSNIKPGTYTLTEAQPPVGYKPSTKQWTVEVEKNGRTTVQGEQVENREEALSDQYPQTGTYPDVQTPYQIIKVDGS

EKNGQHKALNPNPYERVIPEGTLSKRIYQVNNLDDNQYGIELTVSGKTVYEQKDKSVPLDVVILLDNSNSMSNIRNKNA

RRAERAGEATRSLIDKITSDSENRVALVTYASTIFDGTEFTVEKGVADKNGKRLNDSLFWNYDQTSFTTNTKDYSYLKL

TNDKNDIVELKNKVPTEAEDHDGNRLMYQFGATFTQKALMKADEILTQQARQNSQKVIFHITDGVPTMSYPINFNHAT

FAPSYQNQLNAFFSKSPNKDGILLSDFITQATSGEHTIVRGDGQSYQMFTDKTVYEKGAPAAFPVKPEKYSEMKAAGYA

VIGDPINGGYIWLNWRESILAYPFNSNTAKITNHGDPTRWYYNGNIAPDGYDVFTVGIGINGDPGTDEATATSFMQSISS

KPENYTNVTDTTKILEQLNRYFHTIVTEKKSIENGTITDPMGELIDLQLGTDGRFDPADYTLTANDGSRLENGQAVGGP

QNDGGLLKNAKVLYDTTEKRIRVTGLYLGTDEKVTLTYNVRLNDEFVSNKFYDTNGRTTLHPKEVEQNTVRDFPIPKI

RDVRKYPEITISKEKKLGDIEFIKVNKNDKKPLRGAVFSLQKQHPDYPDIYGAIDQNGTYQNVRTGEDGKLTFKNLSDG

KYRLFENSEPAGYKPVQNKPIVAFQIVNGEVRDVTSIVPQDIPAGYEFTNDKHYITNEPIPPKREYPRTGGIGMLPFYLIG

CMMMGGVLLYTRKHPZ

MKSINKFLTMLAALLLTASSLFSAATVFAAGTTTTSVTVHKLLATDGDMDKIANELETGNYAGNKVGVLPANAKEIAG

VMFVWTNTNNEIIDENGQTLGVNIDPQTFKLSGAMPATAMKKLTEAEGAKFNTANLPAAKYKIYEIHSLSTYVGEDGA

TLTGSKAVPIEIELPLNDVVDAHVYPKNTEAKPKIDKDFKGKANPDTPRVDKDTPVNHQVGDVVEYEIVTKIPALANYA

TANWSDRMTEGLAFNKGTVKVTVDDVALEAGDYALTEVATGFDLKLTDAGLAKVNDQNAEKTVKITYSATLNDKAI

VEVPESNDVTFNYGNNPDHGNTPKPNKPNENGDLTLTKTWVDATGAPIPAGAEATFDLVNAQTGKVVQTVTLTTDKN

TVTVNGLDKNTEYKFVERSIKGYSADYQEITTAGEIAVKNWKDENPKPLDPTEPKVVTYGKKFVKVNDKDNRLAGAEF

VIANADNAGQYLARKADKVSQEEKQLVVTTKDALDRAVAAYNALTAQQQTQQEKEKVDKAQAAYNAAYLAANNAF

EWVADKDNENVVKLVSDAQGRFEITGLLAGTYYLEETKQPAGYALLTSRQKFEVTATSYSATGQGIEYTAGSGKDDAT

KVVNKKITIPQTGGIGTIIFAVAGAAIMGIAVYAYVKNNKDEDQLAZ

MTMQKMQKMISRIFFVMALCFSLVWGAHAVQAQEDHTLVLQLENYQEVVSQLPSRDGHRLQVWKLDDSYSYDDRV

QIVRDLHSWDENKLSSFKKTSFEMTFLENQIEVSHIPNGLYYVRSIIQTDAVSYPAEFLFEMTDQTVEPLVIVAKKTDTM

TTKVKLIKVDQDHNRLEGVGFKLVSVARDVSEKEVPLIGEYRYSSSGQVGRTLYTDKNGEIFVTNLPLGNYRFKEVEPL

AGYAVTTLDTDVQLVDHQLVTITVVNQKLPRGNVDFMKVDGRTNTSLQGAMFKVMKEESGHYTPVLQNGKEVVVTS

GKDGRFRVEGLEYGTYYLWELQAPTGYVQLTSPVSFTIGKDTRKELVTVVKNNKRPRIDVPDTGEETLVYLDACCHFV

VWZ

MSHIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQDDDSNGAVKIDGTNQYANGYDVQLAKKIAKDLGKE

PLVVKTKWEGLVPALTSGKIDMIIAGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYL

YNLIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGFKTGEEDTAIAIGLRKNDNR

ISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSSSFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFR

TAPLSENKVIYGLQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYMTEIVRGGILAV

DKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTIIAV

IYFVLTFTVTRILRFIERRMDMDTYTTGANQMQTEDLKZ

MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGKSTFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREK

LGMVFQSFNLFENLNVLENTIVAQTTVLKRERTEAEKIAKENLEKVGMGERYWQAKPKQLSGGQKQRVAIARALSMN

PDAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGVIAEEGKPEDLFTNPKEDRTK

EFLQRYLKZ

MKKYQLLFKISAVFSYLFFVFSLSQLTLIVQNYWQFSSQIGNLFWIQNILSLLFIGVMIVVLVKTGHGYLFRIPRKKWLW

YSILTVLVLVFQISFNVQTAKHVQSTAEGWAVLIGYSGTNFAELGIYIALFFLVPLM?EELIYRGLLQHAFFKHSRFGLDLL

LPSILFALPHFSSLPSLLDIFVFATVGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLTFLHRVLGZ

MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVTDTGGVDDKSFNQSAWEGLQAWGKEHNLSKDN

GFTYFQSTSEADYANNLQQAAGSYNLIFGVGFALNNAVKDAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLA

GVAAAKTTKTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQYAAGADIVYQVAG

GTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKESNFVLVSTLKQVGTTVKDISNKAERGEFPGGQV

IVYSLKDKGVDLAVTNLSEEGKKAVEDAKAKILDGSVKVPEKZ

MSKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTAFGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGL

PGQALAGWILSGWFALSHPDMPRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFPKD

FMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGFEIRAVGLNPHASEYAGISAKRTIIL

SMIISGALAGLGGAVEGLGTFQNVYVQGSSLAIGFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSI

VTASIIFFVSVHYLIERFVKPKKQVKGGKZ

MGVKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYFFAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQ

MVASRKMQEAQPRIKALREQYPGRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGH

FLWINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAPGGVALYWTVSNAYQVLQTY

FLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTKZ

MVIDPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKERIIVVKPGDTIELKDMKIH

AVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKAVNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNN

YGENPVGIQDKMTSIDLLRMAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQD

QHLVEYHHPRGFDDCFEQDSNIQFKALLZ

MFLSGWLSSFANTYIHDLLGVLFPDSPFLNAFESAIAAPLVEEPLKLLSLYFVLALIPVRKLKSLFLLGLASGLGFQMIKDI

GYIRTDLPEGFDFTISRILERIISGIASHWTFSGLAVVGVYLLYRAYKGQKVGKKQGLIFLGLALGTHFLFNSPFVELETEL

PLAIPVVTAIALYGFYHAYCFVEKHNELMTZ

MKVEPRCDVLSRMSHFFIRILIMELQELVERSWAIRQAYHELEVKHHDSKWTVEEDLLALSNDIGNFQRLVMTKQGRY

YDETPYTLEQKLSENIWWLLELSQRLDIDILTEMENFLSDKEKQLNVRTWKZ

MLDWKQFFLAYLRSRSRLFIYLLSLAFLVLLFQFLFASLGIYFLYFFFLCCFVTILFFTWDILVETQVYRQELLYGEREAK

SPLEIALAEKLEAREMELYQQRSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNLV

LQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGGLEIY

MDDQELCIKDTGIGIKNSDVLRVFERGPSGYNGRLTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVL

EZ

MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINTMLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVP

GYGYARVSKKEREKWGCMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKH

ESAIKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKLZ

MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPKFLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDEL

ENQDGLDFKILFLDAADKELVARYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQF

SDQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVMNHPESEDFYQHLLALIEPILP

SYQKEGKSVLTIAMGCTGGQHRSVAFAKRLAQDLSKNWSVNEGHRDKDRRKETVNRSZ

MRKPKITVIGGGTGSPVILKSLREKDVEIAAIVTVADDGGSSGELRKNMQQLTPPGDLRNVLVAMSDMPKFYEKVFQYR

FSEDAGAFAGHPLGNLIIAGLSEMQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVAGESHIVDHRGIIDN

VYVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEIAYVCNIMTQRGETEHFTDSDHV

EVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYLVQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMR

I

IQVKKZ

MKNLIKLLIIRLIVNLADSVFYIVALWHVSNNYSSSMFLGIFIAVNYLPDLLLIFFGPVIDRVNPQKILIISILVQLAVAVIFL

LLLNQISFWVIMSLVFISVMASSISYVIEDVLIPQVVEYDKIVFANSLFSISYKVLDSIFNSFASFLQVAVGFILLVKIDIGIFL

LALFILLLLKFRTSNANIENFSFKYYKREVLQGTKFILNNKLLFKTSISLTLINFFYSFQTVVVPIFSIRYFDGPIFYGIFLTLA

GLGGILGNMLAPIVIKYLKSNQIVGVFLFLNGSSWLVAIVIKDYTLSLILFFVCFMSKGVFNIIFNSLYQQIPPHQLLGRVN

TTIDSIISFGMPIGSLVAGTLIDLNIELVLIAISIPYFLFSYIFYTDNGLKEFSIYZ

MMSNKNKEILIFAILYTVLFMFDGVKLLASLMPSAIANYLVYVVLALYGSFLFKDRLIQQWKEIRKTKRKFFFGVLTGW

LFLILMTVVFEFVSEMLKQFVGLDGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLSGLLSIILV

GLVFALTHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLIILAISIVKZ

LKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGSGKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVH

TVFQSYALFPHMNVFENVAFPLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQ?RQRVAIARAIINQPRVVLLD

EPLSALDLKLRTDMQYELRELQQRLGTTFVFVTHDQEEALAMSDWIFVMNDGEIVQSGTPVDIYDEPINHFVATFIGESN

ILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEVVIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMI

HSTRKAIVGEEIGLDFEPEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKLZ

MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLIN

LLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL

LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFFZ

MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEETKVIEATEPLTILLMGVDTGNVERTETWVGRSDS

MILMTVNPKTKKTTMMSLERDILTRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLV

DAVGGITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVIQKVMEKALSLNSIGH

YQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGEGEILQGVSYQIVSRAHMLEMQNLLRRSLGQEEVTQL

ETNAVLFEDLFGRAPVGDEDNZ

MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEKFVFLLLVFSMSMTCLLALFWRGIEELSLRKMQANLK

RLLAGQEVVQVADPDLDASFKSLSGKLNLLTEALQKAENQSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ

QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLRVSLKQNMTKLPKKIEEHI

FRILQELISNTLRHAQASCLDVYLYQTDVELQLKVVDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLA

VDIRIPLLDKEZ

MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVAVTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGK

IPTLLSGILVMTSCHSIMLLIMGRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDNP

DMARSFGIHTGRMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLIIGEVIFKSLSLAERLVTIVVGSIAY

QFLVWAVIALGFNTSYLRLYSALILAVCLMIPTFKQTILKGAKLSKZ

MKKMKVVSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQELVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIAG

AQLADRVIAEKNNAVADMVFGIGAVDS?NKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDVKEMP

KDWTELGSKYKGKYSISGLQGGTGRAILASILVRYLDDKGELGVSEKGWEVAKEYLKNAYTLQKGESSIVKMLDKEDPI

QYGMMWGSGALVGQKEQNVVFKVMTPEIGVPFVTEQTMVLSTSKKQALAKEFIDWFGQSEIQVEYSKNFGSIPANKD

ALKDLPEDTKKFVDQVKPQNIDWEAVGKHLDEWVEKAELEYVQZ

MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTLRALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSY

ALFPTMTVFDNIAFGLKVKKVAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPLS

NLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPVEIYHNSQTEFVCDFIGDINVLTD

ETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQDFILKGTIIDVEFSGVTIHYTIKVSESQILNVTSIDSQAAIRSVGESV

ELFITPSDVLQFZ

MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSLDAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGIL

CVLFTEYFDIKGAKILKLGYMTSLIYGGVVLATGYKFVYGPYGLITKFLQNVIPSLDPNWFIGYGAVLFIMTFSGTANHT

LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAAPMIVGGKEFQTINPMIITFAGMG

NSRDLAALLAIILGIATTILLTIMNKIEKGGNYISISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPV

AIQTGNLTLSNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKSRFDFLFEYGALLPWLLPSTLLA

VSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVRAILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLS

VIALNFNSLLTDFDLSVFLYHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRKZ

Table 3

ID201-4106.4

ATGATAAAAAATCCTAAATTATTAACCAAGTCTTTTTTAAGAAGTTTTGCAATTCTAGGTGGTGTTGGTCTAGTCAT

TCATATAGCTATTTATTTGACCTTTCCTTTTTATTATATTCAACTGGAGGGGGAAAAGTTTAATGAGAGCGCAAGAG

TGTTTACGGAGTATTTAAAGACTAAGACATCTGATGAAATTCCAAGCTTACTCCAGTCTTATTCAAAGTCCTTGACC

ATATCTGCTCACCTTAAAAGAGATATTGTAGATAAGCGGCTCCCTCTTGTGCATGACTTGGATATTAAAGATGGAAA

GCTATCAAATTATATCGTGATGTTAGATATGTCTGTTAGTACAGCAGATGGTAAACAGGTAACCGTGCAATTTGTTC

ACGGGGTGGATGTCTACAAAGAAGCAAAGAATATTTTGCTTTTGTATCTCCCATATACATTTTTGGTTACAATTGCT

TTTTCCTTTGTTTTTTCTTATTTTTATACTAAACGCTTGCTCAATCCTCTTTTTTACATTTCAGAAGTGACTAGTAA

AATGCAAGATTTGGATGACAATATTCGTTTTGATGAAAGTAGGAAAGATGAAGTTGGTGAAGTTGGAAAACAGATTA

ATGGTATGTATGAGCACTTGTTGAAGGTTATTTATGAGTTGGAAAGTCGTAATGAGCAAATTGTAAAATTGCAAAAT

CAAAAGGTTTCCTTTGTCCGCGGAGCATCACATGAGTTGAAAACCCCTTTAGCCAGTCTTAGAATTATCCTAGAGAA

TATGCAGCATAATATTGGAGATTACAAAGATCATCCAAAATATATTGCAAAGAGTATAAATAAGATTGACCAGATGA

GCCACTTATTAGAAGAAGTACTGGAGTCTTCTAAATTCCAAGAGTGGACAGAGTGTCGTGAGACCTTGACTGTTAAG

CCAGTTTTAGTAGATATTTTATCACGTTATCAAGAATTAGCTCATTCAATAGGTGTTACAATTGAAAATCAATTGAC

AGATGCTACCAGGGTCGTCATGAGTCTTAGGGCATTGGATAAGGTTTTGACAAACCTGATTAGTAATGCAATTAAAT

ATTCAGATAAAAATGGGCGTGTAATCATATCCGAGCAAGATGGCTATCTCTCTATCAAAAATACATGTGCGCCTCTA

AGTGACCAAGAACTAGAACATTTATTTGATATATTCTATCATTCTCAAATCGTGACAGATAAGGATGAAAGTTCCGG

TTTGGGTCTTTACATTGTGAATAATATTTTAGAAAGCTATCAAATGGATTATAGTTTTCTCCCTTATGAACACGGTA

TGGAATTTAAGATTAGCTTGTAG

MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGEKFNESARVFTEYLKTKTSDEIPSLLQSYSKSLT

ISAHLKRDIVDKRLPLVHDLDIKDGKLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIA

FSFVFSYFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIYELESRNEQIVKLQN

QKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIAKSINKIDQMSHLLEEVLESSKFQEWTECRETLTVK

PVLVDILSRYQELAHSIGVTIENQLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPL

SDQELEHLFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISLZ

ID202-4106.9

ATGGATAAAATTATTAAAACTATATCAGAAAGCGGAGCCTTTCGTGCTTTTGTCCTTGATAGCACTGAAACCGTCCG

CACTGCTCAAGAAAAACATCAAACCCAAGCTAGCTCAACTGTAGCGCTTGGTCGAACTCTTATCGCTAGCCAGATTC

TCGCAGCCAATGAAAAAGGAAATACCAAACTTACAGTTAAGGTGTTGGGATCTAGCTCTCTAGGTGCTATTATCACC

GTCGCTGATACCAAGGGGAACGTCAAAGGCTATGTTCAAAATCCTGGTGTTGACATCAAAAAGACTGCGACTGGTGA

AGTCCTAGTCGGACCTTTTGTTGGAAATGGTCAATTCCTCGTTATCACAGACTACGGTACTGGAAATCCTTACAACT

CTATAACTCCCCTCATCTCTGGAGAAATCGGTGAAGACCTTGCCTTTTACCTTACTGAAAGCCAACAAACGCCTTCA

GCGGTCGGCCTCAATGTCCTTTTGGACGAGGAAGACAAGGTCAAGGTTGCAGGTGGTTTCCTAGTTCAAGTCTTGCC

AGGAGCCAAGAAAGAAGAGATTGCTCGCTTTGAAAAACGCATCCAAGAAATGCCAGCTATCTCTACTCTTCTCGAAA

GCGACGACCATATCGAAGCCCTCCTCAAGGCTATCTACGGGGACGAAGCCTACAAGCGTCTTTCTGAAGAAGAAATC

CGTTTCCAATGTGACTGTAGCCATGAACGCTTTATGAACGCTCTTGCCAGCCTTCCAAGCTCAGACTTACAGGAAAT

GAAAGAGGAAGACCACGGGGCAGAAATCACTTGTCAATTCTGCCAAACTACTTACAACTTTGATGAAAAGGACCTGG

AGGAACTCATTCGTGACAAATCTTAA

MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGRTLIASQILAANEKGNTKLTVKVLGSSSLGAIIT

VADTKGNVKGYVQNPGVDIKKTATGEVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPS

AVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEI

RFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYNFDEKDLEELIRDKSZ

ID203-4115

ATGAAATCAATAACTAAAAAGATTAAAGCAACTCTTGCAGGAGTAGCTGCCTTGTTTGCAGTATTTGCTCCATCATT

TGTATCTGCTCAAGAATCATCAACTTACACTGTTAAAGAAGGTGATACACTTTCAGAAATCGCTGAAACTCACAACA

CAACAGTTGAAAAATTGGCAGAAAACAACCACATTGATAACATTCATTTGATTTATGTTGATCAAGAGTTGGTTATC

GATGGCCCTGTAGCGCCTGTTGCAACACCAGCGCCAGCTACTTATGCGGCACCAGCCGCTCAAGATGAAACTGTTTC

AGCTCCAGTAGCAGAAACTCCAGTAGTAAGTGAAACAGTTGTTTCAACTGTAAGCGGATCTGAAGCAGAAGCCAAAG

AATGGATCGCTCAAAAAGAATCAGGTGGTAGTATACAGCTACAAATGGACGTTATATCGGACGTTACCAATTAA

MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVI

DGPVAPVATPAPATYAAPAAQDETVSAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSIQLQMDVISDVTNZ

ID204-4117.1

ATGAATTTAGGAGAATTTTGGTACAATAAAATAAATAAGAACAGAGGAAGAAGGTTAATGAAGAAAGTAAGATTTAT

TTTTTTAGCTCTGCTATTTTTCTTAGCTAGTCCAGAGGGTGCAATGGCTAGTGATGGTACTTGGCAAGGAAAACAGT

ATCTGAAAGAAGATGGCAGTCAAGCAGCAAATGAGTGGGTTTTTGATACTCATTATCAATCTTGGTTCTATATAAAA

GCAGATGCTAACTATGCTGAAAATGAATGGCTAAAGCAAGGTGACGACTATTTTTACCTCAAATCTGGTGGCTATAT

GGCCAAATCAGAATGGGTAGAAGACAAGGGAGCCTTTTATTATCTTGACCAAGATGGAAAGATGAAAAGAAATGCTT

GGGTAGGAACTTCCTATGTTGGTGCAACAGGTGCCAAAGTAATAGAAGACTGGGTCTATGATTCTCAATACGATGCT

TGGTTTTATATCAAAGCAGATGGACAGCACGCAGAGAAAGAATGGCTCCAAATTAAAGGGAAGGACTATTATTTCAA

ATCCGGTGGTTATCTACTGACAAGTCAGTGGATTAATCAAGCTTATGTGAATGCTAGTGGTGCCAAAGTACAGCAAG

GTTGGCTTTTTGACAAACAATACCAATCTTGGTTTTACATCAAAGAAAATGGAAACTATGCTGATAAAGAATGGATT

TTCGAGAATGGTCACTATTATTATCTAAAATCCGGTGGCTACATGGCAGCCAATGAATGGATTTGGGATAAGGAATC

TTGGTTTTATCTCAAATTTGATGGGAAAATGGCTGAAAAAGAATGGGTCTACGATTCTCATAGTCAAGCTTGGTACT

ACTTCAAATCCGGTGGTTACATGACAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTTTTATCTCAAATCTGAT

GGGAAAATAGCTGAAAAAGAATGGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTCAAATCCGGTGGTTACAT

GACAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTTTTACCTCAAATCTGATGGGAAAATAGCTGAAAAAGAAT

GGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTCAAATCTGGTGGCTACATGGCGAAAAATGAGACAGTAGAT

GGTTATCAGCTTGGAAGCGATGGTAAATGGCTTGGAGGAAAAACTACAAATGAAAATGCTGCTTACTATCAAGTAGT

GCCTGTTACAGCCAATGTTTATGATTCAGATGGTGAAAAGCTTTCCTATATATCGCAAGGTAGTGTCGTATGGCTAG

ATAAGGATAGAAAAAGTGATGACAAGCGCTTGGCTATTACTATTTCTGGTTTGTCAGGCTATATGAAAACAGAAGAT

TTACAAGCGCTAGATGCTAGTAAGGACTTTATCCCTTATTATGAGAGTGATGGCCACCGTTTTTATCACTATGTGGC

TCAGAATGCTAGTATCCCAGTAGCTTCTCATCTTTCTGATATGGAAGTAGGCAAGAAATATTATTCGGCAGATGGCC

TGCATTTTGATGGTTTTAAGCTTGAGAATCCCTTCCTTTTCAAAGATTTAACAGAGGCTACAAACTACAGTGCTGAA

GAATTGGATAAGGTATTTAGTTTGCTAAACATTAACAATAGCCTTTTGGAGAACAAGGGCGCTACTTTTAAGGAAGC

CGAAGAACATTACCATATCAATGCTCTTTATCTCCTTGCCCATAGTGCCCTAGAAAGTAACTGGGGAAGAAGTAAAA

TTGCCAAAGATAAGAATAATTTCTTTGGCATTACAGCCTATGATACGACCCCTTACCTTTCTGCTAAGACATTTGAT

GATGTGGATAAGGGAATTTTAGGTGCAACCAAGTGGATTAAGGAAAATTATATCGATAGGGGAAGAACTTTCCTTGG

AAACAAGGCTTCTGGTATGAATGTGGAATATGCTTCAGACCCTTATTGGGGCGAAAAAATTGCTAGTGTGATGATGA

AAATCAATGAGAAGCTAGGTGGCAAAGATTAG

MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASDGTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIK

ADANYAENEWLKQGDDYFYLKSGGYMAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDA

WFYIKADGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFYIKENGNYADKEWI

FENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSD

GKIAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMAKNETVD

GYQLGSDGKWLGGKTTNENAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTED

LQALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLENPFLFKDLTEATNYSAE

ELDKVFSLLNINNSLLENKGATFKEAEEHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFD

DVDKGILGATKWIKENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKDZ

ID205-4118.1

ATGAAAAAATTAGGTACATTACTCGTTCTCTTTCTTTCTGCAATCATTCTTGTAGCATGTGCTAGCGGAAAAAAAGA

TACAACTTCTGGTCAAAAACTAAAAGTTGTTGCTACAAACTCAATCATCGCTGATATTACTAAAAATATTGCTGGTG

ACAAAATTGACCTTCATAGTATCGTTCCGATTGGGCAAGACCCACACGAATACGAACCACTTCCTGAAGACGTTAAG

AAAACTTCTGAGGCTAATTTGATTTTCTATAACGGTATCAACCTTGAAACAGGTGGCAATGCTTGGTTTACAAAATT

GGTAGAAAATGCCAAGAAAACTGAAAACAAAGACTACTTCGCAGTCAGCGACGGCGTTGATGTTATCTACCTTGAAG

GTCAAAATGAAAAAGGAAAAGAAGACCCACACGCTTGGCTTAACCTTGAAAACGGTATTATTTTTGCTAAAAATATC

GCCAAACAATTGAGCGCCAAAGACCCTAACAATAAAGAATTCTATGAAAAAAATCTCAAAGAATATACTGATAAGTT

AGACAAACTTGATAAAGAAAGTAAGGATAAATTTAATAAGATCCCTGCTGAAAAGAAACTCATTGTAACCAGCGAAG

GAGCATTCAAATACTTCTCTAAAGCCTATGGTGTCCCAAGTGCTTACATCTGGGAAATCAATACTGAAGAAGAAGGA

ACTCCTGAACAAATCAAGACCTTGGTTGAAAAACTTCGCCAAACAAAAGTTCCATCACTCTTTGTAGAATCAAGTGT

GGATGACCGTCCAATGAAAACTGTTTCTCAAGACACAAACATCCCAATCTACGCTCAAATCTTTACTGACTCTATCG

CAGAACAAGGTAAAGAAGGCGACAGCTACTACAGCATGATGAAATACAACCTTGACAAGATTGCTGAAGGATTGGCA

AAATAA

MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVK

KTSEANLIFYNGINLETGGNAWFTKLVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNI

AKQLSAKDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWEINTEEEG

TPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLA

KZ

ID206-4119.1

ATGGAATGGTATAAAAAAATCGGACTTCTTGCAACTACAGGTTTAGCTTTGTTTGGGCTCGGCGCTTGCTCCAACTA

TGGTAAATCTGCGGATGGCACAGTGACCATCGAGTATTTCAACCAGAAAAAAGAAATGACCAAAACCTTGGAAGAAA

TCACTCGTGATTTTGAGAAGGAAAACCCTAAGATCAAGGTCAAAGTCGTCAATGTACCAAATGCTGGTGAAGTATTG

AAGACACGCGTTCTCGCAGGAGATGTGCCTGATGTGGTCAATATTTACCCACAGTCCATCGAACTGCAAGAATGGGC

AAAAGCAGGTGTTTTTGAAGATTTGAGCAACAAAGACTACCTGAAACGCGTGAAAAATGGCTACGCTGAAAAATATG

CTGTAAACGAAAAAGTTTACAACGTTCCTTTTACAGCTAATGCTTATGGAATTTACTACAACAAAGATAAATTCGAA

GAACTGGGCTTGAAGGTTCCTGAAACCTGGGATGAATTTGAACAGTTAGTCAAAGATATCGTTGCTAAAGGACAAAC

ACCATTTGGAATTGCAGGTGCAGATGCTTGGACACTCAATGGTTACAATCAATTAGCCTTTGCGACAGCAACAGGTG

GAGGAAAAGAAGCAAATCAATACCTTCGTTATTCTCAACCAAATGCCATTAAATTGTCGGATCCGATTATGAAAGAT

GATATCAAGGTCATGGACATCCTTCGCATCAATGGATCTAAGCAAAAGAACTGGGAAGGTGCTGGCTATACCGATGT

TATCGGAGCCTTCGCACGTGGGGATGTCCTCATGACACCAAATGGGTCTTGGGCGATCACAGCGATTAATGAACAAA

AACCGAACTTTAAGATTGGGACCTTCATGATTCCAGGAAAAGAAAAAGGACAAAGCTTAACCGTTGGTGCGGGAGAC

TTGGCATGGTCTATCTCAGCCACCACCAAACATCCAAAAGAAGCCAATGCCTTTGTGGAATATATGACCCGTCCAGA

AGTCATGCAAAAATACTACGATGTGGACGGATCTCCAACAGCGATCGAAGGGGTCAAACAAGCAGGAGAAGATTCAC

CGCTTGCTGGTATGACCGAATATGCCTTTACGGATCGTCACTTGGTCTGGTTGCAACAATACTGGACCAGTGAAGCA

GACTTCCATACCTTGACCATGAACTATGTCTTGACCGGTGATAAACAAGGCATGGTCAATGATTTGAATGCCTTCTT

TAACCCGATGAAAGCGGATGTGGATTAG

MEWYKKIGLLATTGLALFGLGACSNYGKSADGTVTIEYFNQKKEMTKTLEEITRDFEKENPKIKVKVVNVPNAGEVL

KTRVLAGDVPDVVNIYPQSIELQEWAKAGVFEDLSNKDYLKRRVKNGYAEKYAVNEKVYNPFTANAYGIYYNKDKFE

ELGLKVPETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQPNAIKLSDPIMKD

DIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAITAINEQKPNFKIGTFMIPGKEKGQSLTVGAGD

LAWSISATTKHPKEANAFVEYMTRPEVMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEA

DFHTLTMNYVLTGDKQGMVNDLNAFFNPMKADVDZ

ID207-4123.1

ATGAAGAAAATCAAACCGCATGGACCGTTACCAAGTCAGACTCAGCTAGCTTATCTGGGAGATGAACTAGCAGCTTT

TATCCACTTCGGTCCTAATACCTTTTATGACCAAGAATGGGGGACTGGACAGGAGGATCCTGAGCGCTTTAACCCGA

GTCAGTTGGATGCGCGTGAGTGGGTTCGTGTGCTCAAGGAAACGGGCTTCAAAAAGTTGATTTTGGTGGTCAAGCAC

CACGATGGCTTTGTCCTTTATCCGACAGCTCACACAGATTATTCGGTTAAGGTCAGTCCTTGGAGGAGAGGAAAGGG

CGACTTGCTCCTTGAAGTATCCCAAGCTGCCACAGAGTTTGATATGGATATGGGGGTCTACCTGTCACCGTGGGATG

CCCATAGTCCCCTCTATCATGTGGACCGAGAAGCGGACTACAATGCCTATTATCTGGCTCAGTTGAAGGAAATCTTA

TCAAATCCTAACTATGGGAATGCTGGTAAGTTCGCTGAGGTTTGGATGGATGGTGCCAGAGGAGAGGGCGCGCAAAA

GGTTAATTATGAATTTGAAAAATGGTTTGAAACCATTCGTGACCTGCAGGGCGATTGCTTGATTTTTTCAACAGAAG

GCACCAGTATCCGCTGGATTGGCAATGAACGAGGGTATGCAGGTGATCCACTGTGGCAAAAGGTGAATCCTGATAAA

CTAGGAACAGAAGCAGAGCTGAACTATCTTCAGCACGGGGATCCCTCGGGCACGATTTTTTCAATCGGAGAGGCAGA

TGTTTCCATCCGTCCAGGCTGGTTCTACCATGAGGATCAGGATCCTAAGTCTCTCGAGGAGTTGGTCGAAATCTACT

TTCACTCAGTAGGGCGAGGAACTCCACTCTTGCTTAATATTCCGCCGAATCAAGCTGGGCTCTTTGATGCAAAGGAT

ATTGAACGACTTTATGAATTTGCGACCTATCGCAATGAGCTCTATAAAGAAGATTTGGCTCTGGGAGCTGAGGTATC

TGGTCCAGCTCTTTCCGCAGACTTTGCTTGTCGCCATTTGACAGACGGCCTTGAGACCAGCTCTTGGGCAAGCGATG

CAGACTTGCCCATCCAGTTAGAACTCGACTTAGGTTCTCCTAAAACTTTTGATGTAATTGAGTTAAGAGAAGATTTG

AAGCTAGGGCAACGAATCGCTGCTTTTCATGTGCAAGTAGAGGTGGATGGTGTCTGGCAGGAGTTTGGTTCGGGTCA

TACTGTTGGTTACAAACGTCTCTTACGAGGAGCAGTTGTTGAGGCACAGAAGATACGTGTAGTCATTACAGAATCAC

AGGCTTTGCCTTTGTTGACCAAGATTTCCCTTTATAAAACTCCTGGATTATCAAAAAAAGAAGTTGTTCAGGAACTA

GCATTTGCAGAAAAAAGCCTAGCTGTGGCAAAGGGAGAAAATGCCTATTTTACAGTTAAGCGCAGAGAATGTAGTGG

TCCTTTAGAAGCTAAGATTTCGATTCAACCGGGGACAGGTGTCCATGGTGTCGCCTATCAGGATGAGATTCAAGTCC

TTGCGTTTCAAACTGGTGAGACTGAAAAAAGTCTGACGCTACCAACCTTGTATTTCGCAGGAGATAAAACCTTGGAT

TTCTATCTGAACCTAACGGTGGATGGTCAGCTTGTGGATCAACTTCAAGTCCAAGTTTCATAA

MKKIKPHGPLPSQTQLAYLGDELAAFIKFGPNTFYDQEWGTGQEDPERFNPSQLDAREWVRVLKETGFKKLILVVKH

HDGFVLYPTAHTDYSVKVSPWRRGKGDLLLEVSQAATEFDMDMGVYLSPWDAHSPLYHVDREADYNAYYLAQLKEIL

SNPNYGNAGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGDCLIFSTEGTSIRWIGNERGYAGDPLWQKVNPDK

LGTEAELNYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLEELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKD

IERLYE?FATYRNELYKEDLALGAEVSGPALSADFACRHLTDGLETSSWASDADLPIQLELDLGSPKTFDVIELREDL

KLGQRIAAFHVQVEVDGVWQEFGSGHTVGYKRLLRGAVVEAQKIRVVITESQALPLLTKISLYKTPGLSKKEVVQEL

AFAEKSLAVAKGENAYFTVKRRECSGPLEAKISIQPGTGVHGVAYQDEIQVLAFQTGETEKSLTLPTLYFAGDKTLD

FYLNLTVDGQLVDQLQVQVSZ

ID208-4125.12

ATGCTTGAAAGACTGAAAAGAATACATTATATGTTTTGGATCAGTTTAATTTTTATGATTTTCCCCATCCTGTCTGT

AGTGACTGGGTGGCTTTCTGCCTGGCATTTATTGATTGATATTCTATTTGTAGTGGCATATTTGGGTGTTTTAACAA

CTAAGAGCCAGCGCCTATCTTGGCTATATTGGGGCCTCATGCTGACTTATGTAGTTGGGAATACTGCCTTTGTTGCT

GTTAATTATATCTGGTTTTTCTTTTTCCTATCCAATCTCTTAAGTTATCATTTCAGCGTACGTAGTTTAAAGTCTTT

ACATGTCTGGACTTTTCTTCTTGCTCAAGTCCTTGTTGTGGGGCAACTGTTGATTTTTCAGAGAATCGAAGTTGAGT

TTCTATTCTATCTACTTGTAATTCTTACTTTTGTCGATTTAATGACTTTTGGATTGGTTCGGATTCGTATTGTCGAG

GATTTGAAAGAAGCTCAGGTCAAGCAAAATGCTCAGATAAATCTATTGCTTGCTGAAAATGAACGTAGTCGTATCGG

TCAGGATTTGCATGATAGTCTGGGACATACCTTTG?CTATGCTGAGTGTCAAGACAGATTTAGCCTTGCAGTTATTTC

AGATGGAGGCTTATCCACAGGTGGAAAAGGAATTAAAAGAAATTCACCAGATCAGCAAGGATCCATGA

MLERLKRIHYMFWISLIFMIFPILSVVTGWLSAWHLLIDILFVVAYLGVLTTKSQRLSWLYWGLMLTYVVGNTAFVA

VNYIWFFFFLSNLLSYHFSVRSLKSLHVWTFLLAQVLVVGQLLI?FQRIEVEFLFYLLVILTFVDLMTFGLVRIRIVE

DLKEAQVKQNAQINLLLAENERSRIGQDLHDSLGHTFAMLSVKTDLALQLFQMEAYPQVEKELKEIHQISKDPZ

ID209-4126.3

ATGAATGATAAGTTAAAAATCTTCTTGTTGCTAGGAGTATTTTTTCTAGCCATAACCGGTTTCTATGTTCTATTGAT

ACGAAATGCAGGGCAGACAGATGCCTCGCAAATTGAAAAGGCGGCAGTTAGCCAAGGAGGAAAAGCAGTGAAAAAAA

CAGAAATTAGTAAAGACGCAGACTTGCACGAAATTTATCTAGCTGGAGGTTGTTTCTGGGGAGTGGAGGAATATTTC

TCACGTGTTCCCGGGGTGACGGATGCCGTTTCAGGCTATGCAAATGGTAGAGGAGAAACAACCAAGTACGAATTGAT

TAACCAAACAGGTCATGCAGAAACCGTCCATGTCACCTATGATGCCAAGCAAATTTCTCTCAAGGAAATCCTGCTTC

ACTATTTCCGCATTATCAATCCAACCAGCAAAAATAAACAAGGAAATGATGTGGGGACCCAGTACCGTACTGGTGTT

TATTACACAGATGACAAGGATTTGGAAGTGATTAACCAAGTCTTTGATGAGGTGGCTAAGAAATACGATCAACCTCT

AGCAGTTGAAAAGGAAAACTTGAAGAATTTTGTGGTGGCTGAGGATTACCATCAAGACTATCTCAAGAAAAATCCAA

ATGGCTACTGCCATATCAATGTTAATCAGGCGGCCTATCCTGTCATTGATGCCAGCAAATATCCAAAACCAAGTGAT

GAGGAATTGAAAAAGACCCTGTCACCTGAGGAGTATGCAGTTACCCAGGAAAATCAAACAGAACGAGCTTTCTCAAA

CCGTTACTGGGATAAATTTGAATCCGGTATCTATGTGGATATAGCAACTGGGGAACCTCTCTTTTCATCAAAAGACA

AATTTGAGTCTGGTTGTGGCTGGCCTAGTTTTACCCAACCCATCAGTCCAGATGTTGTCACCTACAAGGAAGATAAG

TCCTACAATATGACGCGTATGGAAGTGCGGAGCCGAGTAGGAGATTCTCACCTTGGGCATGTCTTTACGGATGGTCC

ACAGGACAAGGGCGGCTTACGTTACTGTATCAATAGCCTCTCTATCCGCTTTATTCCCAAAGACCAAATGGAAGAAA

AAGgcTACGCTTATTTACTAGATTATGTTGATTAA

MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADLHEIYLAGGCFWGVEEYF

SRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGV

YYTDDKDLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSD

EELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPDVVTYKEDK

SYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVDZ

ID210-4127.1

ATGAAAAAGAAATGGATGTATTATGCTGCTTGTTCTTCTAATGAATCTGCCGATGACAGTTCATCTGATAAAGGAGA

CGGCGGTTCGCTAGTCGTTTATTCACCAAACTCAGAGGGCTTAATTGGAGCAACTATTCCTGCCTTTGAAGAAAAAT

ATGGTATCAAAGTAGAACTGATTCAAGCTGGTACTGGAGAACTTTTCAAAAAACTAGAGTCAGAAAAAGAAGTTCCT

GTAGCTGATGTTATCTTTGGTGGTTCTTATACACAATATACTACCCACGGAGAACTCTTTGAAAACTATACTTCAAA

AGAAAATGATAATGTTATCAAAGAATATCAAAACACAACTGGCTACTCTACTCCTTATACACTAGATGGTAGTGTTT

TAATCGTCAACCCTGATTTAACTAAAGGCATGAACATCGAAGGATATAACGATCTTTTCAAACCTGAACTAAAAGGA

AAAATCGCAACTGCTGACCCAGCAAACTCTTCTAGCGCCTTTGCTCAATTAACAAATATGCTACAAGCTCAAGGTGG

TTACAAAGATGATAAGGCTTGGTCTTATGTAAAAGATCTTTTCACACTTATTGATGGTAAAATCGGTTCAAGTTCAT

CTAGTGTCTATAAAGTAGTCGCTGATGGAGAAATGGCTGTTGGTCTCTCTTATGAAGATCCAGCAGTTAAACTCTTA

AATGACGGAGCTAACATTAAGGTAGTCTATCCAAAAGAAGGAACCGTCTTCCTACCTGCTAGTGCTGCTATCGTTAA

AAAATCTAAAAATATGGAAAATGCCAAGAAATTTATCGATTTTATTATCTCTCAAGAAGTACAAGATACACTTGGTA

CAACCACTACTAACCGTCCTGTTCGTAAAAATGCTAAAACAAGCGAAAACATGAAACCAATTGACAAAATCAAAACA

CTCACTGAAGATTATGATTATGTCATCAAGAATAAATCAGATATCGTTAAGAAATACAACGAAGTCTTTACAGATAT

CCAATCTAAACAGTAA

MKKKWMYYAACSSNESADDSSSDKGDGGSLVVYSPNSEGLIGATIPAFEEKYGIKVELIQAGTGELFKKLESEKEVP

VADVIFGGSYTQYTTHGELFENYTSKENDNVIKEYQNTTGYSTPYTLDGSVLIVNPDLTKGMNIEGYNDLFKPELKG

KIATADPANSSSAFAQLTNMLQAQGGYKDDKAWSYVKDLFTLIDGKIGSSSSSVYKVVADGEMAVGLSYEDPAVKLL

NDGANIKVVYPKEGTVFLPASAAIVKKSKNMENAKKFIDFIISQEVQDTLGTTTTNRPVRKNAKTSENMKPIDKIKT

LTEDYDYVIKNKSDIVKKYNEVTDIQSKQZ

ID211-4127.2

ATGAGTGAGATCAAAATTATTAACGCCAAAAAAATCTACCACGATGTCCCTGTTATTGAGAATTTGAACATTACAAT

TCCAAGGAAGTCTCTTTACCCTTCTTGGAGCTTCAGGATGTGGGAAAACGACCCTTCTTCGTATGATTGCAGGTT

TCAACAGTATCGAAGGTGGAGAATTTTACTTCGATGATACAAAAATCAATAATATGGAACCCAGCAAACGCAATATC

GGGATGGTTTTCCAAAACTACGCTATTTTKCCCACATTTGACTGTCCGAGACAACGTTGCTTTTGGTCTTATGCAAAA

GAAGGTTCCAAAAGAAGAATTGATTCAACAGACCAACAAGTATCTTGAACTCATGCAAATTGCTCAATATGCGGATC

GAAAGCCCGATAAACTCAGTGGTGGACAACAACAACGTGTCACCTTGGCATGCGCCTTAGCGGTTAATCCAAGTGTT

CTCCTCATGGACGAGCCACTTAGTAATCTGGAGGCCAAACTTCGCTTGGATATGCGTCAAGCCATCCGAGAAATCCA

ACACGAAGTGGGAATTACAACTGTTTATGTAACCCACGACCAAGAAGAAGCCATGGCTATTTCAGACCAAATTGCTG

TTATGAAAGATGGGGTGATCCAACAAATCGGCCGACCAAAAGAACTCTATCATAAACCAGCTAATGAGTTTGTGGCA

ACCTTTATCGGACGCACAAATATTATCCCTGCCAATCTTGAAAAACGGAGCGACGGCGCTTATATCGTCTTTTCAGA

TGGCTATGCCCTTCGAATGCCAGCTCTTGATCAGGTTGAGGAGCAAGCTATTCATGTAAGCATTCGTCCCGAAGAGT

TTATCAAAGATGAATCTGGAGATATTGAAGGAACTATTAGAGATAGCGTCTATCTTGGACTAAATACGGATTATTTC

ATTGAGACAGGTTTTGCCTCAAAAATTCAAGTTAGTGAAGAATCAACTTTTGAAGAAGATCTACAAAAAGGCAATCG

TATTCGTCTACGAATCAATACGCAAAAATTAAACATCTTTTCTGCAGATGGTTCCCAAAACCTGATAAAAGGAGTCA

ACCATGGAACGTAA

MSEIKIINAKKIYHDVPVIENLNITIPKGSLFTLLGASGCGKTTLLRMIAGFNSIEGGEFYFDDTKINNMEPSKRNI

GMVFQNYAIFPHLTVRDNVAFGLMQKKVPKEELIQQTNKYLELMQIAQYADRKPDKLSGGQQQRVTLACALAVNPSV

LLMDEPLSNLEAKLRLDMRQAIREIQHEVGITTVYVTHDQEEAMAISDQIAVMKDGVIQQIGRPKELYHKPANEFVA

TFIGRTNIIPANLEKRSDGAYIVFSDGYALRMPALDQVEEQAIHVSIRPEEFIKDESGDIEGTIRDSVYLGLNTDYF

IETGFASKIQVSEESTFEEDLQKGNRIRLRINTQKLNIFSADGSQNLIKGVNHGTZ

ID212-4136.1

ATGAAGAAAAAATTATTGGCAGGTGCCATCACACTATTATCAGTAGCAACTTTAGCAGCTTGTTCGAAAGGGTCAGA

AGGTGCAGACCTTATCAGCATGAAAGGGGATGTCATTACAGAACATCAATTTTATGAGCAAGTGAAAAGCAACCCTT

CAGCCCAACAAGTCTTGTTAAATATGACCATCCAAAAAGTTTTTGAAAAACAATATGGCTCAGAGCTTGATGATAAA

GAGGTTGATGATACTATTGCCGAAGAAAAAAAACAATATGGCGAAAACTACCAACGTGTCTTGTCACAAGCAGGTAT

GACTCTTGAAACACGTAAAGCTCAAATTCGTACAAGTAAATTAGTTGAGTTGGCAGTTAAGAAGGTAGCAGAAGCTG

AATTGACAGATGAAGCCTATAAGAAAGCCTTTGATGAGTACACTCCAGATGTAACGGCTCAAATCATCCGTCTTAAT

AATGAAGATAAGGCCAAAGAAGTTCTCGAAAAAGCCAAGGCAGAAGGTGCTGATTTTGCTCAATTAGCCAAAGATAA

TTCAACTGATGAAAAAACAAAAGAAAATGGTGGAGAAATTACCTTTGATTCTGCTTCAACAGAAGTACCTGAGCAAG

TCAAAAAAGCCGCTTTCGCTTTAGATGTGGATGGTGTTTCTGATGTGATTACAGCAACTGGCACACAAGCCTACAGT

AGCCAATATTACATTGTAAAACTCACTAAGAAAACAGAAAAATCATCTAATATTGATGACTACAAAGAAAAATTAAA

AACTGTTATCTTGACTCAAAAACAAAATGATTCAACATTTGTTCAAAGCATTATCGGAAAAGAATTGCAAGCAGCCA

ATATCAAGGTTAAGGACCAAGCCTTCCAAAATATCTTTACCCAATATATCGGTGGTGGAGATTCAAGCTCAAGCAGT

AGTACATCAAACGAATAG

MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKSNPSAQQVLLNMTIQKVFEKQYGSELDDK

EVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLN

NEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYS

SQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSS

STSNEZ

ID213-4137.3

ATGAAAAAAAATATTAAACAATATGTAACCTTAGGTACTGTAGTGGTATTATCAGCATTTGTTGCTAACTCAGTTGC

AGCTCAGGAGACTGAAACTTCTGAAGTATCAACACCAAAGTTGGTGCAACCTGTTGCACCAACGACTCCGATTTCGG

AAGTACAACCTACATCGGATAACTCTTCGGAAGTTACTGTACAACCT?CGAACAGTTGAAACTACTGTTAAGGATCCA

TCTTCTACAGCGGAAGAAACTCCTGTCTTAGAAAAAAATAATGTTACTTTAACAGGGGGCGGAGAAAATGTTACTAA

AGAGTTAAAGGATAAATTTACTAGCGGTGACTTTACTGTAGTGATTAAGTACAATCAGTCAAGTGAGAAAGGCTTAC

AAGCTCTGTTTGGAATATCTAATTCCAAACCCGGTCAACAAAATAGTTATGTAGATGTGTTCCTTAGAGACAATGGT

GAGTTGGGGATGGAAGCGCGTGATACTTCTTCCAATAAAAATAACCTAGTATCCAGACCTGCTTCAGTTTGGGGTAA

GTACAAACAAGAGGCTGTGACTAACACTGTTGCAGTAGTAGCAGATTCAGTCAAAAAAACATATTCTTTATACGCAA

ATGGTACAAAAGTAGTAGAAAAGAAAGTGGATAATTTCCTAAACATCAAGGATATTAAAGGTATTGATTACTATATG

CTTGGGGGAGTGAAACGTGCAGGAAAAACGGCGTTTGGTTTTAACGGAACACTAGAAAATATCAAATTCTTTAATAG

TGCATTGGATGAAGAAACTGTTAAAAAGATGACAACAAACGCTGTTACTGGACATTTAATTTATACGGCTAATGATA

CAACAGGTTCTAACTATTTCCGTATTCCAGTTCTGTATACTTTTAGCAATGGTCGGGTATTTTCAAGCATTGACGCT

CGTTACGGTGGAACTCATGATTTCTTGAATAAAATTAATATTGCTACAAGTTATAGTGATGATAATGGTAAGACATG

GACTAAACCAAAATTAACATTGGCATTCGATGATTTTGCGCCAGTACCATTAGAATGGCCTCGTGAAGTTGGTGGAC

GTGACTTACAAATCAGCGGTGGTGCAACCTATATTGACTCTGTTATTGTTGAAAAAAAGAACAAACAAGTACTCATG

TTTGCTGATGTGATGCCTGCTGGAGTAAGTTTTAGAGAAGCAACTAGAAAAGATTCAGGTTATAAACAAATTGATGG

TAATTATTACCTTAAATTAAGGAAACAAGGTGATACTGATTACAATTATACTATTCGTGAGAATGGTACTGTATACG

ACGATCGTACCAACAGACCAACTGAATTTTCAGTAGATAAAAATTTCGGTATTAAACAAAATGGTAATTATTTGACG

GTAGAGCGG

MKKNIKQYVTLGTVVVLSAFVANSVAAQETETSEVSTPKLVQPVAPTTPISEVQPTSDNSSEVTVQPRTVETTVKDP

SSTAEETPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNG

ELGMEARDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVEKKVDNFLNIKDIKGIDYYM

LGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDA

RYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDD?FAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLM

FADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLT

VER

ID214-4185

ATGAAAAAATTTAGCCTATTACTAGCTATCCTACCATTTTTGGTTGCCTGTGAGAATCAAGCTACACCCAAAGAGAC

TAGCGCTCAAAAGACAATCGTCCTTGCTACAGCTGGCGACGTGCCACCATTTGACTACGAAGACAAGGGCAATCTGA

CAGGCTTTGATATCGAAGTTTTAAAGGCAGTAGATGAAAACTCAGCGACTACGAGATTCAATTCCAAAGAACCGCC

TGGGAGAGCATCTTCCCAGGACTTGATTCTGGTCACTAT?CAGGCTGCGGCCAATAACTTGAGTTACACAAAAGAGCG

TGCTGAAAAATACCTTTACTCGCTTCCAATTTCCAACAATCCCCTCGTCCTTGTCAGCAACAAGAAAAATCCTTTGA

CTTCTCTTGACCAGATCGCTGGTAAAACAACACAAGAGGATACCGGAACTTCTAACGCTCAATTCATCAATAACTGG

AATCAGAAACACACTGATAATCCCGCTACAATTAATTTTTCTGGTGAGGATATTGGTAAACGAATCCTAGACCTTGC

TAACGGAGAGTTTGATTTCCTAGTTTTTGACAAGGTATCCGTTCAAAAGATTATCAAGGACCGTGGTTTAGACCTCT

CAGTCGTTGATTTACCTTCTGCAGATAGCCCCAGCAATTATATCATTTTCTCAAGCGACCAAAAAGAGTTTAAAGAG

CAATTTGATAAAGCGCTCAAAGAACTCTATCAAGACGGAACCCTTGAAAAACTCAGCAATACCTATCTAGGTGGTTC

TTACCTCCCAGATCAATCTCAGTTACAATAA

MKKFSLLLAILPFLVACENQATPKETSAQKTIVLATAGDVPPFDYEDKGNLTGFDIEVLKAVDEKLSDYEIQFQRTA

WESIFPGLDSGHYQAAANNLSYTKERAEKYLYSLPISNNPLVLVSNKKKNPLTSLDQIAGKTTQEDTGTSNAQFINNW

NQKHTDNPATINFSGEDIGKRILDLANGEFDFLVFDKVSVQKIIKDRGLDLSVVDLPSADSPSNYIIFSSDQKEFKE

QFDKALKELYQDGTLEKLSNTYLGGSYLPDQSQLQZ

ID215-4211.1

ATGAAAAAAAATAGTTTATATATCATATCCTCACTCTTTTTTGCTTGTGTCTTATTTGTCTATGCTACGGCGACGAA

TTTTCAAAACAGTACCAGTGCTAGGCAGGTAAAAACGGAAACCTATACTAATACAGTAACAAATGTCCCTATTGACA

TACGCTATAATAGTGATAAGTATTTTATTAGCGGTTTTGCTTCAGAAGTATCAGTGGTCTTGACTGGTGCAAATCGC

CTATCGCTAGCTAGTGAAATGCAAGAAAGTACACGTAAATTCAAGGTTACTGCTGACCTAACAGATGCCGGTGTTGG

AACGATTGAAGTTCCTTTGAGCATTGAAGATTTACCCAATGGGCTGACCGCTGTGGCGACTCCGCAAAAAATTACAG

TCAAGATTGGTAAGAAGGCTCAGAAGGATAAGGTAAAGATTGTACCAGAGATTGACCCTAGTCAAATTGATAGTCGG

GTACAAATTGAAAATGTCATGGTGTCAGATAAAGAAGTGTCTATTACGAGTGACCAAGAGACATTGGATAGAATTGA

TAAGATTATCGCTGTTTTGCCAACTAGCGAACGTATAACAGGTAATTACAGTGGTTCAGTACCTTTGCAGGCAATCG

ACCGCAATGGTGTTGTCTTACCGGCAGTTATCACTCCGTTTGATACAATAATGAAGGTGACTACAAAACCAGTAGCA

CCAAGTTCAAGCACATCAAATTCAAGTACAAGCAGTTCATCGGAGACATCTTCGTCAACGAAAGCAACTAGTTCAAA

AACGAATTAA

MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNTVTNVPIDIRYNSDKYFISGFASEVSVVLTGANR

LSLASEMQESTRKFKVTADLTDAGVGTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSR

VQIENVMVSDKEVSITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITPFDTIMKVTTKPVA

PSSSTSNSSTSSSSETSSSTKATSSKTNZ

ID216-4127.3

ATGTTGATTGGCGAAGGGTATCGGACTTTCCCTGTCCTGATTTATACCCAATTTATTAGCGAGGTTGGAGGAAATTC

TGCTTTTGCAATTATGGCGATTATCATTGCCTTGGCAATTTTCCTTATCCAAAAACACATTGCAAACCGCTACAGTT

TCAGCATGAATCTGCTCCATCCAATTGAGCCTAAAAAAACTACAAAAGGAAAAATGGCTGCCATTTATGCAACAGTC

TACGGAATTATCTTTATCTCTGTTTTACCTCAAATCTACTTAATTTATACCTCTTTCCTAAAAACATCAGGTATGGT

ATCTGTTAAAGGTTATTCTCCAAACAGTTACAAGGTAGCTTTCCATCGTATGGGATCTGCTATTTTCAATACCATTC

GTATCCCTTTGATTGCCTTAGTTCTAGTTGTTCTATTTGCGACATTTATCTCCTACCTAGCCGTTAGAAAACGGAAT

TTGTTTACAAACTTAATTGACAGCCTCAGTATGGTACCTTATATTGTACCAGGAACCGTTCTAGGGATTGCCTTCAT

TTCTTCCTTCAATACTGGTCTATTTGGAAGTGGATTTCTTATGATTACAGGGACTGCTTTCATCTTGATTATGTCTC

TATCTGCCAGAAGATTACCTTATACTATTCGCTCATCTGTTGCTAGCTTACAACAAATAGCACCAAGTATTGAAGAA

GCTGCTGAAAGCTTAGGAAGTAGTCGTCTCAATACCTTTGCTAAGATTACAACTCCAATGATGCTATCTGGTATCAT

TTCTGGAGCCATCTTATCTTGA

MLIGEGYRTFPVLIYTQFISEVGGNSAFAIMAIIIALAIFLIQKHIANRYSFSMNLLHPIEPKKTTKGKMAAIYATV

YGIIFISVLPQIYLIYTSFLKTSGMVSVKGYSPNSYKVAFHRMGSAIFNTIRIPLIALVLVVLFATFISYLAVRKRN

LFTNLIDSLSMVPYIVPGTVLGIAFISSFNTGLFGSGFLMITGTAFILIMSLSARRLPYTIRSSVASLQQIAPSIEE

AAESLGSSRLNTFAKITTPMMLSGIISGAILSZ

Table 4

ID301

ATGAATAAGAAAAAAATGATTTTAACAAGTCTAGCCAGCGTCGCTATCTTAGGGGCTGGTTTTGTTACGTCTCAGCC

TACTTTTGTAAGAGCAGAAGAATCTCCACAAGTTGTCGAAAAATCTTCATTAGAGAAGAAATATGAGGAAGCAAAAG

CAAAAGCTGATACTGCCAAGAAAGATTACGAAACGGCTAAAAAGAAAGCAGAAGACGCTCAGAAAAAGTATGAAGAT

GATCAGAAGAGAACTGAGGAGAAAGCTCGAAAAGAAGCAGAAGCATCTCAAAAATTGAATGATGTGGCGCTTGTTGT

TCAAAATGCATATAAAGAGTACCGAGAAGTTCAAAATCAACGTAGTAAATATAAATCTGACGCTGAATATCAGAAAA

AATTAACAGAGGTCGACTCTAAAATAGAGAAGGCTAGGAAAGAGCAACAGGACTTGAAAATAAATTTAATGAAGTA

AGAGCAGTTGTAGTTCCTGAACCAAATGCGTTGGCTGAGACTAAGAAAAAAGCAGAAGAAGCTAAAGCAGAAGAAAA

AGTAGCTAAGAGAAAATATGATTATGCAACTCTAAAGGTAGCACTAGCGAAGAAAGAAGTAGAGGCTAAGGAACTTG

AAATTGAAAAACTTCAATATGAAATTTCTACTTTGGAACAAGAAGTTGCTACTGCTCAACATCAAGTAGATAATTTG

AAAAAACTTCTTGCTGGTGCGGATCCTGATGATGGCACAGAAGTTATAGAAGCTAAATTAAAAAAAGGAGAAGCTGA

GCTAAACGCTAAACAAGCTGAGTTAGCAAAAAAACAACAGAACTTGAAAAACTTCTTGACAGCCTTGATCCTGAAG

GTAAGACTCAGGATGAATTAGATAAAGAAGCAGAAGAAGCTGAGTTGGATAAAAAAGCTGATGAACTTCAAAATAAA

GTTGCTGATTTAGAAAAAGAAATTAGTAACCTTGAAATATTACTTGGAGGGGCTGATCCTGAAGATGATACTGCTGC

TCTTCAAAATAAATTAGCTGCTAAAAAAGCTGAGTTAGCAAAAAAACAAACAGAACTTGAAAAACTTCTTGACAGCC

TTGATCCTGAAGGTAAGACTCAGGATGAATTAGATAAAGAAGCAGAAGAAGCTGAGTTGGATAAAAAAGCTGATGAA

CTTCAAAATAAAGTTGCTGATTTAGAAAAAGAAATTAGTAACCTTGAAATATTACTTGGAGGGGCTGATTCTGAAGA

TGATACTGCTGCTCTTCAAAATAAATTAGCTACTAAAAAAGCTGAATTGGAAAAAACTCAAAAAGAATTAGATGCAG

CTCTTAATGAGTTAGGCCCTGATGGAGATGAAGAAGAAACTCCAGCGCCGGCTCCTCAACCAGAGCAACCAGCTCCT

GCACCAAAACCAGAGCAACCAGCTCCAGCTCCAAAACCAGAGCAACCAGCTCCTGCACCAAAACCAGAGCAACCAGC

TCCAGCTCCAAAACCAGAGCAACCAGCTCCAGCTCCAAAACCAGAGCAACCAGCTAAGCCGGAGAAACCAGCTGAAG

AGCCTACTCAACCAGAAAAACCAGCCACTCCAAAAACAGGCTGGAAACAAGAAAACGGTATGTGGTATTTCTACAAT

ACTGATGGTTCAATGGCAATAGGTTGGCTCCAAAACAACGGTTCATGGTACTACCTAAACGCTAACGGCGCTATGGC

AACAGGTTGGGTGAAAGATGGAGATACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCA

AAGTATCAGATAAATGGTACTATGTCAACAGCAATGGCGCTATGGCGACAGGCTGGCTCCAATACAATGGCTCATGG

TACTACCTCAACGCTAATGGTGATATGGCGACAGGATGGCTCCAATACAACGGTTCATGGTATTACCTCAACGCTAA

TGGTGATATGGCGACAGGATGGGCTAAAGTCAACGGTTCATGGTACTACCTAAACGCTAACGGTGCTATGGCTACAG

GTTGGGCTAAAGTCAACGGTTCATGGTACTACCTAAACGCTAACGGTTCAATGGCAACAGGTTGGGTGAAAGATGGA

GATACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTA

TGTCAATGGCTTAGGTGCCCTTGCAGTCAACACAACTGTAGATGGCTATAAAGTCAATGCCAATGGTGAATGGGTTT

AA

MNKKKKMILTSLASVAILGAGFVTSQPTFVRAEESPQVVEKSSLEKKYEEAKAKADTAKKDYETTKKKAEDAQKKYED

DQKRTEEKARKEAEASQKLNDVALVVQNAYKEYREVQNQRSKYKSDAEYQKKLTEVDSKIEKARKEQQDLQNKFNEV

RAVVVPEPNALAETKKKAEEAKAEEKVAKRKYDYATLKVALAKKEVEAKELEIEKLQYEISTLEQEVATAQHQVDNL

KKLLAGADPDDGTEVIEAKLKKGEAELNAKQAELAKKQTELEKLLDSLDPEGKTQDELDKEAEEAELDKKADELQNK

VADLEKEISNLEILLGGADPEDDTAALQNKLAAKKAELAYKQTELEKLLDSLDPEGKTQDELDKEAEEAELDKKADE

LQNKVADLEKEISNLEILLGGADSEDDTAALQNKLATKKAELEKTQKELDAALNELGPDGDEEETPAPAPQPEQPAP

APKPPEQPAPAPKPEQPAPAPKPEQPAPAPKPEQPAPAPKPEQPAKKPEKPAEEPTQPEKPATPKTGWKQENGMWYFYN

TDGSMAIGWLQNNGSWYYLNANGAMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNSNGAMATGWLQYNGSW

YYLNANGDMATGWLQYNGSWYYLNANGDMATGWAKVNGSWYYLNANGAMATGWAKVNGSWYYLNANGSMATGWVKDG

DTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANG?EWVZ

ID302

ATGTTTGCATCAAAAAGCGAAAGAAAAGTACATTATTCAATTCGTAAATTTAGTGTTGGAGTAGCTAGTGTAGTTGT

TGCCAGTCTTGTTATGGGAAGTGTGGTTCATGCGACAGAGAACGAGGGAGCTACCCAAGTACCCACTTCTTCTAATA

GGGCAAATGAAAGTCAGGCAGAACAAGGAGAACAACCTAAAAAACTCGATTCAGAACGAGATAAGGCAAGGAAAGAG

GTCGAGGAATATGTAAAAAAAATAGTGGGTGAGAGCTATGCAAAATCAACTAAAAAGCGACATACAATTACTGTAGC

TCTAGTTAACGAGTTGAACAACATTAAGAACGAGTATTTGAATAAAATAGTTGAATCAACCTCAGAAAGCCAACTAC

AGATACTGATGATGGAGAGTCGATCAAAAGTAGATGAAGCTGTGTCTAAGTTTGAAAAGGACTCATCTTCTTCGTCA

AGTTCAGACTCTTCCACTAAACCGGAAGCTTCAGATACAGCGAAGCCAAACAAGCCGACAGAACCAGGAGAAAAGGT

AGCAGAAGCTAAGAAGAAGGTTGAAGAAGCTGAGAAAAAAGCCAAGGATCAAAAAGAAGAAGATCGTCGTAACTACC

CAACCATTACTTACAAAACGCTTGAACTTGAAATTGCTGAGTCCGATGTGGAAGTTAAAAAAGCGGAGCTTGAACTA

GTAAAAGTGAAAGCTAACGAACCTCGAGACGAGCAAAAAATTAAGCAAGCAGAAGCGGAAGTTGAGAGTAAACAAGC

TGAGGCTAAAGGTTAAAAAAAATCAAGACAGATCGTGAAGAAGCAGAAGAAGAAGCTAAACGAAGAGCAGATGCTA

AAGAGCAAGGTAAACCAAAGGGGCGGGCAAAACGAGGAGTTCCTGGAGAGCTAGCAACACCTGATAAAAAAGAAAAT

GATGCGAAGTCTTCAGATTCTAGCGTAGGTGAAGAAACTCTTCCAAGCCCATCCCTGAAACCAGAAAAAAGGTAGC

AGAAGCTGAGAAGAAGGTTGAAGAAGCTAAGAAAAAAGCCGAGGATCAAAAAGAAGAAGATCGCCGTAACTACCCAA

CCAATACTTACAAAACGCTTGAACTTGAAATTGCTGAGTCCGATGTGGAAGTTAAAAAAGCGGAGCTTGAACTAGTA

AAAGAGGAAGCTAAGGAACCTCGAAACGAGGAAAAAGTTAAGCAAGCAAAAGCGGAAGTTGAGAGTAAAAAAGCTGA

GGCTACAAGGTTAGAAAAAATCAAGACAGATCGTAAAAAAGCAGAAGAAGAAGCTAAACGAAAAGCAGCAGAAGAAG

ATAAAGTTAAAGAAAAACCAGCTGAACAACCACAACCAGCGCCGGCTCCAAAAGCAGAAAAACCAGCTCCAGCTCCA

AAACCAGAGAATCCAGCTGAACAACCAAAAGCAGAAAAACCAGCTGATCAACAAGCTGAAGAAGACTATGCTCGTAG

ATCAGAAGAAGAATATAATCGCTTGACTCAACAGCAACCGCCAAAAACTGAAAAACCAGCACAACCATCTACTCCAA

AAACAGGCTGGAAACAAGAAAACGGTATGTGGTACTTCTACAATACTGATGGTTCAATGGCGACAGGATGGCTCCAA

AACAATGGCTCATGGTACTACCTCAACAGCAATGGCGCTATGGCGACAGGATGGCTCCAAAACAATGGTTCATGGTA

CTATCTAAACGCTAATGGTTCAATGGCAACAGGATGGCTCCAAAACAATGGTTCATGGTACTACCTAAACGCTAATG

GTTCAATGGCGACAGGATGGCTCCAATACAATGGCTCATGGTACTACCTAAACGCTAATGGTTCAATGGCGACAGGA

TGGCTCCAATACAATGGCTCATGGTACTACCTAAACGCTAATGGTGATATGGCGACAGGTTGGGTGAAAGATGGAGA

TACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTATG

TCAATGGCTCAGGTGCCCTTGCAGTCAACACAACTGTAGATGGCTATGGAGTCAATGCCAATGGTGAATGGGTAAAC

TAA

MFASKSERKVHYSIRKFSVGVASVVVASLVMGSVVHATENEGATQVPTSSNRANESQAEQGEQPKKKLDSERDKARKE

VEEYVKKIVGESYAKSTKKRHTITVALVNELNNIKNEYLNKIVESTSESQLQILMMESRSKVDEAVSKFEKDSSSSS

SSDSSTKPEASDTAKPNKPTEPGEKVAEAYKKVEEAEKKAKDQKEEDRRNYPTITYKTLELEIAESDVEVKKAELEL

VKVKANEPRDEQKIKQAEAEVESKQAEATRLKKIKTDREEAEEEAKRRADAKEQGKPKGRAKRGVPGELATPDKKEN

DAKSSDSSVGEETLPSPSLKPEKKVAEAEKKVEEAKKKAEDQKEEDRRNYPTNTYKTLELEIAESDVEVKKAELELV

KEEAKEPRNEEKVKQAKAEVESKKAEATPLEKIKTDRKKAEEEAKKRKAAEEDKVKEKPAEQPQPAPAPKAEKPAPAP

KPENPAEQPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKTGWKQENGMWYFYNTDGSMATGWLQ

NNGSWYYLNSNGAMATGWLQNNGSWYYLNANGSMATGWLQNNGSWYYLNANGSMATGWLQYNGSWYYLNANGSMATG

WLQYNGSWYYLNANGDMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGVNANGEWVN

Z

ID303

ATGGTAAAAAGACGTATAAGGAGAGGGACGAGAGAACCTGAAAAAGTTGTTGTTCCTGAGCAATCATCTATTCCTTC

GTATCCTGTATCTGTTACATCTAACCAAGGAACAGATGTAGCAGTAGAACCAGCTAAAGCAGTTGCTCCAACAACAG

ACTGGAAACAAGAAAATGGTATGTGGTATTTTTATAATACTGATGGTTCCATGGCAACAGGTTGGGTACAAGTTAAT

AGTTCATGGTACTACCTCAACAGCAACGGTTCTATGAAAGTCAATCAATGGTTCCAAGTTGGTGGTAAATGGTATTA

TGTAAATACATCGGGTGAGTTAGCGGTCAATACAAGTATAGATGGCTATAGAGTCAATGATAATGGTGAATGGGTGC

GTTAA

MVKRRIRRGTREPEKVVVPEQSSIPSYPVSVTSNQGTDVAVEPAKAVAPTTDWKQENGMWYFYNTDGSMATGWVQVN

SSWYYLNSNGSMKVNQWFQVGGKWYYVNTSGELAVNTSIDGYRVNDNGEWVRZ

ID304

CTGAATACAAGTTTTGTTCATGCTGCTGATGGGATTCAATATGTCAGAGATGATACTAGAGATAAAGAAGAGGGAAT

AGAGTATGATGACGCTGACAATGGGGATATTATTGTAAAAGTAGCGACTAAACCTAAGGTAGTAACCAAGAAAATTT

CAAGTACGCGAATTCGTTATGAAAAAGATGAAACAAAAGACCGTAGTGAAAATCCTGTTACAATTGATGGAGAGGAT

GGCTATGTAACTACGACAAGGACCTACGATGTTAATCCAGAGACTGGTTATGTTACCGAACAGGTTACTGTTGATAG

AAAAGAAGCCACGGATACAGTTATCAAAGTTCCAGCTAAAAGCAAGGTTGAAGAAGTTCTTGTTCCATTTGCTACTA

AATATGAAGCAGACAATGACCTTTCTGCAGGACAGGAGCAAGAGATTACTCTAAAAGAATGGGAAAACAGTTACA

ACGATAACTTATAATGTAGATGGAAAGAGTGGACAAGTAACTGAGAGTACTTTAAGTCAAAAAAAAGACTCTCAAAC

AAGAGTTGTTAAAAAAAGAACCAAGCCCCAAGTTCTTGTCCAAGAAATTCCAATCGAAACAGAATATCTCGATGGCC

CAACTCTTGATAAAAGTCAAGAAGTAGAAGAAGTAGGAGAAATTGGTAAATTACTCTTACTACAATCTATACTGTAG

LNTSFVHAADGIQYVRDDTRDKEEGIEYDDADNGDIIVKVATKPKVVTKKISSTRIRYEKDETKDRSENPVTIDGED

GYVTTTRTYDVNPETGYVTEQVTVDRKEATDTVIKVPAKSKVEEVLVPFATKYEADNDLSAGQEQEITLGKNGKTVT

TITYNVDGKSGQVTESTLSQKKDSQTRVVKKRTKPQVLVQEIPIETEYLDGPTLDKSQEVEEVGEIGKLLLLQSILZ

ID305

ATGAAGCTTTTGAAAAAAATGATGCAAATCGCACTAGCCACATTTTTCTTCGGTTTGTTAGCGACAAATACAGTATT

TGCAGATGATTCTGAAGGATGGCAGTTTGTCCAAGAAAATGGTAGAACCTACTACAAAAAGGGGGATCTAAAAGAAA

CCTACTGGAGAGTGATAGATGGGAAGTACTATTATTTTGATCCTTTATCCGGAGAGATGGTTGTCGGCTGGCAATAT

ATACCTGCTCCACACAAGGGGGTTACGATTGGTCCTTCTCCAAGAATAGAGATTGCTCTTAGACCAGATTGGTTTTA

TTTTGGTCAAGATGGTGTATTACAAGAATTTGTTGGCAAGCAAGTTTTAGAAGCAAAAACTGCTACGAATACCAACA

AACATCATGGGGAAGAATATGATAGCCAAGCAGAGAAACGAGTCTATTATTTTGAAGATCAGCGTAGTTATCATACT

TTAAAAACTGGTTGGATTTATGAAGAGGGTCATTGGTATTATTTACAGAAGGATGGTGGCTTTGATTCGCGCATCAA

CAGATTGACGGTTGGAGAGCTAGCACGTGGTTGGGTTAAGGATTACCCTCTTACGTATGATGAAGAGAAGCTAAAAG

CAGCTCCATGGTACTATCTAAATCCAGCAACTGGCATTATGCAAACAGGTTGGCAATATCTAGGTAATAGATGGTAC

TACCTCCATTCGTCAGGAGCTATGGCAACTGGCTGGTATAAGGAAGGCTCAACTTGGTACTATCTAGATGCTGAAA

TGGTGATATGAGAACTGGCTGGCAAAACCTTGGGAACAAATGGTACTATCTCCGTTCATCAGGAGCTATGGCAACTG

GTTGGTATCAGGAAAGTTCGACTTGGTACTATCTAAATGCAAGTAATGGAGATATGAAAACAGGCTGGTTCCAAGTC

AATGGTAACTGGTACTATGCCTATGATTCAGGTGCTTTAGCTGTTAATACCACAGTAGGTGGTTACTACTTAAACTA

TAATGGTGAATGGGTTAAGTAA

MKLLKKMMQIALATFFFGLLATNTVFADDSEGWQFVQENGRTYYKKGDLKETYWRVIDGKYYYFDPLSGEMVVGWQY

IPAPHKGVTIGPSPRIEIALRPDWFYFGQDGVLQEFVGKQVLEAKTATNTNKHHGEEYDSQAEKRVYYFEDQRSYHT

LKTGWIYEEGHWYYLQKDGGFDSRINRLTVGELARGWVKDYPLTYDEEKLKAAPWYYLNPATGIMQTGWQYLGNRWY

YLHSSGAMATGWYKEGSTWYYLDAENGDMRTGWQNLGNKWYYLRSSGAMATGWYQESSTWYYLNASNGDMKTGWFQV

NGNWYYAYDSGALAVNTTVGGYYLNYNGEWVKZ

ID306

TTGGCTGGTAGATATGGTTCTGCTGTTCAGTGTACAGAAGTGACTGCCTCAAACCTTTCAAACAGTTAAAACTAAAGC

TACGGTTGTAGAAAAACCACTGAAAGATTTTAGAGCGTCTACGTCTGATCAGTCTGGTTGGGTGGAATCTAATGGTA

AATGGTATTTCTATGAGTCTGGTGATGTGAAGACAGGTTGGGTGAAAACAGATGGTAAATGGTACTATTTGAATGAC

TTAGGTGTCATGCAGACTGGATTTGTAAAATTTTCTGGTAGCTGGTATTACTTGAGCAATTCAGGTGCTATGTTTAC

AGGCTGGGGAACAGATGGTAGCAGATGGTTCTACTTTGACGGCTCAGGAG?CTATGAAGACAGGCTGGTACAAGGAAA

ATGGCACTTGGTATTACCTTGACGAAGCAGGTATCATGAAGACAGGTTGGTTTAAAGTCGGACCACACTGGTACTAT

GCCTACGGTTCAGGAGCTTTGGCTGTGAGCACAACAACACCAGATGGTTACCGTGTAAATGGTAATGGTGAATGGGT

AAACTAG

LAGRYGSAVQCTEVTASNLSTVKTKATVVEKPLKDFRASTSDQSGWVESNGKWYFYESGDVKTGWVKTDGKWYYLND

LGVMQTGFVKFSGSWYYLSNSGAMFTGWGTDGSRWFYFDGSGAMKTGWYKENGTWYYLDEAGIMKTGWFKVGPHWYY

AYGSGALAVSTTTPDGYRVNGNGEWVNZ

ID307

ATGAAAATTTTGAAAAAAACTATGCAAGTTGGACTGACAGTATTTTTCTTTGGTTTGCTAGGGACCAGTACAGTATT

TGCAGATGATTCTGAAGGATGGCAGTTTGTCCAAGAAAACGGAAGAACCTACTACAAAAAGGGGGACCTCAAAGAAA

CCTACTGGCGAGTGATTGATGGTAAGTACTATTATTTTGATTCTCTATCTGGAGAGATGGTTGTCGGCTGGCAATAT

ATCCCGTTTCCATCTAAAGGTAGTACAATTGGTCCTTACCCAAATGGTATCAGATTAGAAGGTTTTCCAAAGTCAGA

GTGGTACTACTTCGATAAAAATGGAGTGCTACAAGAGTTTGTTGGTTGGAAAACATTAGAGATTAAAACTAAAGACA

GTGTTGGAAGAAAGTACGGGGAAAAACGTGAAGATTCAGAAGATAAAGAAGAGAAGCGTTATTATACGAACTATTAC

TTTAATCAAAATCATTCTTTAGAGACAGGTTGGCTTTATGATCAGTCTAACTGGTATTATCTAGCTAAGACGGAAAT

TAATGGAGAAAACTACCTTGGTGGTGAAAGACGTGCGGGGTGGATAAACGATGATTCGACTTGGTACTACCTAGATC

CAACAACTGGTATTATGCAAACAGGTTGGCAATATCTAGGTAATAAGTGGTACTACCTCCGTTCCTCAGGAGCAATG

GCCACTGGCTGGTATCAGGAAGGTACCACTTGGTATTATTTAGACCACCCAAATGGCGATATGAAAACAGGTTGGCA

AAACCTTGGGAACAAATGGTACTATCTCCGTTCATCAGGAGCTATGGCAACTGGTTGGTATCAAGATGGTTCAACTT

GGTACTACCTAAATGCAGGTAATGGAGACATGAAGACAGGTTGGTTCCAGGTCAATGGCAACTGGTACTATGCTTAT

AGCTCAGGTGCTTTGGCAGTGAATACGACCGTAGATGGCTATTCTGTCAACTATAATGGCGAATGGGTTCGGTAA

MKILKKTMQVGLTVFFFGLLGTSTVFADDSEGWQFVQENGRTYYKKGDLKETYWRVIDGKYYYFDSLSGEMVVGWQY

IPFPSKGSTIGPYPNGIRLEGFPKSEWYYFDKNGVLQEFVGWKTLEIKTKDSVGRKYGEKREDSEDKEEKRYYTNYY

FNQNHSLETGWLYDQSNWYYLAKTEINGENYLGGERRAGWINDDSTWYYLDPTTGIMQTGWQYLGNKWYYLRSSGAM

ATGWYQEGTTWYYLDHPNGDMKTGWQNLGNKWYYLRSSGAMATGWYQDGSTWYYLNAGNGDMKTGWFQVNGNWYYAY

SSGALAVNTTVDGYSVNYNGEWVRZ

ID308

ATGAAAAAGAAATTAACTAGTTTAGCACTTGTAGGCGCTTTTTTAGGTTTGTCATGGTATGGGAATGTTCAGGCTCA

AGAAAGTTCAGGAAATAAAATCCACTTTATCAATGTTCAAGAAGGTGGKCAGTGATGCGATTATTCTTGAAAGCAATG

GACATTTTGCCATGGTGGATACAGGAGAAGATTATGATTTCCCAGATGGAAGTGATTCTCGCTATCCATGGAGAGAA

GGAATTGAAACGTCTTATAAGCATGTTCTAACAGACCGTGTCTTTCGTCGTTTGAAGGAATTGGGTGTCCAAAAACT

TGATTTTATTTTGGTGACCCATACCCACAGTGATCATATTGGAAATGTTGATGAATTACTGTCTACCTATCCAGTTG

ACCGAGTCTATCTTAAGAAATATAGTGATAGTCGTATTACTAATTCTGAACGTCTATGGGATAATCTGTATGGCTAT

GATAAGGTTTTACAGACTGCTGCAGAAAAGGTGTTTCAGTTATTCAAAATATCACACAAGGGGATGCTCATTTTCA

GTTTGGGGACATGGATATTCAGCTCTATAATTATGAAAATGAAACTGATTCATCGGGTGAATTAAAGAAAATTTGGG

ATGACAATTCCAATTCCTTGATTAGCGTGGTGAAAGTCAATGGCAAGAAAATTTACCTTGGGGGCGATTTAGATAAT

GTTCATGGAGCAGAAGACAAGTATGGTCCTCTCATTGGAAAAGTTGATTTGATGAAGTTTAATCATCACCATGATAC

CAACAAATCAAATACCAAGGATTTCATTAAAAATTTGAGTCCGAGTTTGATTGTTCAAACTTCGGATAGTCTACCTT

GGAAAAATGGTGTTGATAGTGAGTATGTTAATTGGCTCAAAGAACGAGGAATTGAGAGAATCAACGCAGCCAGCAAA

GACTATGATGCAACAGTTTTTGATATTCGAAAAGACGGTTTTGTCAATATTTCAACATCCTACAAGCCGATTCCAAG

TTTTCAAGCTGGTTGGCATAAGAGTGCATATGGGAACTGGTGGTATCAAGCGCCTGATTCTACAGGAGAGTATGCTG

TCGGTTGGAATGAAATCGAAGGTGAATGGTATTACTTTAACCAAACGGGTATCTTGTTACAGAATCAATGGAAAAAA

TGGAACAATCATTGGTTCTATTTGACAGACTCTGGTGCTTCTGCTAAAAATTGGAAGAAAATCGCTGGAATCTGGTA

TTATTTTAACAAAGAAAACCAGATGGAAATTGGTTGGATTCAAGATAAAGAGCAGTGGTATTATTTGGATGTTGATG

GTTCTATGAAGACAGGATGGCTTCAATATATGGGGCAATGGTATTACTTTGCTCCATCAGGGGAAATGAAAATGGGC

TGGGTAAAAGATAAAGAAACCTGGTACTATATGGATTCTACTGGTGTCATGAAGACAGGTGAGATAGAAGTTGCTGG

TCAACATTATTATCTGGAAGATTCAGGAGCTATGAAGCAAGGCTGGCATAAAAAGGCAAATGATTGGTATTTCTACA

AGACAGACGGTTCACGAGCTGTGGGTTGGATCAAGGACAAGGATAAATGGTACTTCTTGAAAGAAAATGGTCAATTA

CTTGTGAACGGTAAGACACCAGAAGGTTATACTGTGGATTCAAGTGGTGCCTGGTTAGTGGATGTTTCGATCGAGAA

ATCTGCTACAATTAAAACTACAAGTCATTCAGAAATAAAAGAATCCAAAGAAGTAGTGAAAAAGGATCTTGAAAATA

AAGAAACGAGTCAACATGAAAGTGTTACAAATTTTTCAACTAGTCAAGATTTGACATCCTCAACTTCACAAAGCTCT

GAAACGAGTGTAAACAAATCGGAATCAGAACAGTAG

MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSDAIILESNGHFAMVDTGEDYDFPDGSDSRYPWRE

GIETSYKHVLTDRVFRRLKELGVQKLDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGY

DKVLQTAAEKGVSVIQNITQGDAHFQFGDMDIQLYNYENETDSSGELKKIWDDNSNSLISVVKVNGKKIYLGGDLDN

VHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQTSDSLPWKNGVDSEYVNWLKERGIERINAASK

DYDATVFDIRKDGFVNISTSYKPIPSFQAGWHKSAYGNWWYQAPDSTGEYAVGWNEIEGEWYYFNQTGILLQNQWKK

WNNHWFYLTDSGASAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYMGQWYYFAPSGEMKMG

WVKDKETWYYMDSTGVMKTGEIEVAGQHYYLEDSGAMKQGWHKKANDWYFYKTDGSRAVGWIKDKDKWYFLKENGQL

LVNGKTPEGYTVDSSGAWLVDVSIEKSATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNFSTSQDLTSSTSQSS

ETSVNKSESEQZ

ID309

ATGGAAATTAATGTGAGTAAATTAAGAACAGATTTGCCTCAAGTCGGCGTGCAACCATATAGGCAAGTACACGCACA

CTCAACTGGGAATCCGCATTCAACCGTACAGAATGAAGCGGATTATCACTGGCGGAAAGACCCAGAATTAGGTTTTT

TCTCGCACATTGTTGGGAACGGTTGCATCATGCAGGTAGGACCTGTTGATAATGGTGCCTGGGACGTTGGGGGCGGT

TGGAATGCTGAGACCTATGCAGCGGTTGAACTGATTGAAAGCCATTCAACCAAAGAAGAGTTCATGACGGACTACCG

CCTTTATATCGAACTCTTACGCAATCTAGCAGATGAAGCAGGTTTGCCGAAAACGCTTGATACAGGGAGTTTAGCTG

GAATTAAAACGCACGAGTATTGCACGAATAACCAACCAAACAACCACTCAGACCACGTTGACCCTTATCCATATCTT

GCTAAATGGGGCATTAGCCGTGAGCAGTTTAAGCATGATATTGAGAACGGCTTGACGATTGAAACAGGCTGGCAGAA

GAATGACACTGGCTACTGGTACGTACATTCAGACGGCTCTTATCCAAAAGACAAGTTTGAGAAAATCAATGGCACTT

GGTACTACTTTGACAGTTCAGGCTATATGCTTGCAGACCGCTGGAGGAAGCACACAGACGGCAACTGGTACTGGTTC

GACAACTCAGGCGAAATGGCTACAGGCTGGAAGAAAATCGCTGATAAGTGGTACTATTTCAACGAAGAAGGTGCCAT

GAAGACAGGCTGGGTCAAGTACAAGGACACTTGGTACTACTTAGACGCTAAAGAAGGCGCCATGGTATCAAATGCCT

TTATCCAGTCAGCGGACGGAACAGGCTGGTACTACCTCAAACCAGACGGAACACTGGCAGACAAGCCAGAATTCACA

GTAGAG?CCAGATGGCTTGATTACAGTAAAATAA

MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGG

WNAETYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYL

AKWGISREQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLADRWRKHTDGNWYWF

DNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFT

VEPDGLITVKZ

ID310

ATGGGCACAACAGGATTTACAATAATTGACTTAATTATCTTGATTGTTTATTTACTTGCGGTGTTGGTTGCAGGTAT

CTATTTCTCTAAAAAAGAGATGAAAGGAAAAGAGTTCTTTAAAGGAGATGGTTCGGTTCCTTGGTATGTTACTTCGG

TATCCATTTTTGCCACAATGCTCAGTCCGATTTCCTTCTTGGGACTCGCTGGTAGCTCTTATGCAGGTAGCTGGATT

TTATGGTTTGCTCAATTAGGGATGGTAGTAGCTATTCCACTGACAATTCGTTTTATCTTACCTATCTTTGCACGGAT

AGACATCGATACGGCATATGATTACTTGGATAAACGTTTTAATTCTAAAGCACTTCGTATTATTTCAGCACTCTTGT

TTATTATTTATCAATTGGGACGTATGTCTATCATTATGTACCTCCCATCAGCTGGTTTATCAGTATTGACAGGAATT

GACATCAATATTTTGATTATTTTGATGGGTGTAGTTGCAATTGTTTATTCTTATACTGGTGGTCTAAAATCCGTATT

ATGGACAGACTTTATTCAAGGTGTGATTCTGATTAGTGGTGTCGTTTTAGCTTTATTTGTACTGATTGCTAATATTA

AAGGTGGCTTTGGTGCAGTAGCAGAAACATTAGCAAACGGGAAATTCCTTGCTGCAAATGAAAAACTTTTCGATCCT

AACTTGCTTTCAAACTCCATCTTTTTAATTGTGATGGGTTCAGGCTTTACAATCTTGTCTTCCTATGCTTCATCTCA

AGATTTGGTTCAACGTTTTACTACAACACAAAATATTAAGAAACTTAATAAGATGTTGTTCACAAACGGTGTTTTGT

CACTTGCAACTGCAACAGTCTTTTACTTGATTGGTACAGGCTTGTACGTATTCTATCAAGTACAAAATGCAGATAGT

GCAGCTAGCAATATCCCTCAAGACCAAATCTTTATGTACTTTATTGCATACCAGTTACCAGTAGGTATCACAGGTTT

GATCTTGGCAGCGATTTATGCAGCATCTCAATCAACTATTTCAACAGGTTTGAACTCTGTTGCAACTTCATGGACAT

TGGATATTCAAGATGTCATTTCTAAAAATATGTCAGACAATCGTCGTACGAAAATTGCACAATTCGTATCTCTAGCA

GTAGGTTTATTCTCAATTGGTGTTTCCATTGTCATGGCTCACTCAGATATTAAATCTGCATACGAATGGTTCAATAG

TTTCATGGGACTTGTACTTGGTCTACTTGGTGGTGTATTTATTCTTGGATTTGTTTCTAAAAAAGCAAATAAACAAG

GTGCTTATGCAGCGCTGATTGTATCAACCATCGTCATGGTATTTATTAAATACTTCCTTCCTCCAACAGCTGTTAGC

TACTGGGCATATTCATTGATTTCAATCTCTGTATCAGTAGTTTCAGGTTATATTGTATCTGTTCTTACTGGAAATAA

AGTATCTGCACCTAAATATACAACGATTCATGATATTACAGAAATTAAAGCGGATTCAAGTTGGGAAGTTCGTCACT

AA

MGTTGFTIIDLIILIVYLLAVLVAGIYFSKKEMKGKEFFKGDGSVPWYVTSVSIFATMLSPISFLGLAGSSYAGSWI

LWFAQLGMVVAIPLTIRFILPIFARIDIDTAYDYLDKRFNSKALRIISALLFIIYQLGRMSIIMYLPSAGLSVLTGI

DINILIILMGVVAIVYSYTGGLKSVLWTDFIQGVILISGVVLALFVLIANIKGGFGAVAETLANGKFLAANEKLFDP

NLLSNSIFLIVMGSGFTILSSYASSQDLVQRFTTTQNIKKLNKMLFTNGVLSLATATVFYLIGTGLYVFYQVQNADS

AASNIPQDQIFMYFIAYQLPVGITGLILAAIYAASQSTISTGLNSVATSWTLDIQDVISKNMSDNRRTKIAQFVSLA

VGLFSIGVSIVMAHSDIKSAYEWFNSFMGLVLGLLGGVFILGFVSKKANKQGAYAALIVSTIVMVFIKYFLPPTAVS

YWAYSLISISVSVVSGYIVSVLTGNKVSAPKYTTIHDITEIKADSSWEVRHZ

ID311

ATGAAAATTAATAAAAAATATCTAGCAGGTTCAGTGGCAGTCCTTGCCCTAAGTGTTTGTTCCTATGAGCTTGGTCG

TCACCAAGCTGGTCAGGATAAGAAAGAGTCTAATCGAGTTGCTTATATAGATGGTGATCAGGCTGGTCAAAAGGCAG

AAAACTTGACACCAGATGAAGTCAGTAAGAGGGAGGGGATCAACGCCGAACAAATCGTCATCAAGATTACGGATCAA

GGTTATGTGACCTCTCATGGAGACCATTATCATTACTATAATGGCAAGGTCCCTTATGATGCCATCATCAGTGAAGA

GCTCCTCATGAAAGATCCGAATTATCAGTTGAAGGATTCAGACATTGTCAATGAAATAAGGGTGGTTATGTCATCA

AGGTAGACGGAAAATACTATGTTTACCTTAAGGATGCAGCTCATGCGGATAATATTCGGACAAAAGAAGAGATTAAA

CGTCAGAAGCAGGAACGCAGTCATAATCACGGGTCAGGAGCTAACGATCATGCAGTAGCTGCAGCCAGAGCCCAAGG

ACGCTATACAACGGATGATGGGTATATCTTCAATGCATCTGATATCATTGAGGACACGGGTGATGCTTATATCGTTC

CTCACGGCGACCATTACCATTACATTCCTAAGAATGAGTTATCAGCTAGCGAGTTAGCTGCTGCAGAAGCCTATTGG

AATGGGAAGCAGGGATCTCGTCCTTCTTCAAGTTCTAGTTATAATGCAAATCCAGCTCAACCAAGATTGTCAGAGAA

CCACAATCTGACTGTCACTCCAACTTATCATCAAAATCAAGGGGAAAACATTTCAAGCCTTTTACGTGAATTGTATG

CTAAACCCTTATCAGAACGCCATGTGGAATCTGATGGCCTTATTTTCGACCCAGCGCAAATCACAAGTCGAACCGCC

AGAGGTGTAGCTGTCCCTCATGGTAACCATTACCACTTTATCCCTTATGAACAAATGTCTGAATTGGAAAAACGAAT

TGCTCGTATTATTCCCCTTCGTTATCGTTCAAACCATTGGGTACCAGATTCAAGACCAGAACAACCAAGTCCACAAT

CGACTCCGGAACCTAGTCCAAGTCCGCAACCTGCACCAAATCCTCAACCAGCTCCAAGCAATCCAATTGATGAGAAA

TTGGTCAAAGAAGCTGTTCGAAAAGTAGGCGATGGTTATGTCTTTGAGGAGAATGGAGTTTCTCGTTATATCCCAGC

CAAGGATCTTTCAGCAGAAACAGCAGCAGGCATTGATAGCAAACTGGCCAAGCAGGAAAGTTTATCTCATAAGCTAG

GAGCTAAGAAAACTGACCTCCCATCTAGTGATCGAGAATTTTACAATAAGGCTTATGACTTACTAGCAAGAATTCAC

CAAGATTTACTTGATAATAAAGGTCGACAAGTTGATTTTGAGGCTTTGGATAACCTGTTGGAACGACTCAAGGATGT

CCCAAGTGATAAAGTCAAGTTAGTGGATGATATTCTTGCCTFCTTAGCTCCGATTCGTCATCCAGAACGTTTAGGAA

AACCAAATGCGCAAATTACCTACACTGATGATGAGATTCAAGTAGCCAAGTTGGCAGGCAAGTACACAACAGAAGAC

GGTTATATCTTTGATCCTCGTGATATAACCAGTGATGAGGGGGATGCCTATGTAACTCCACATATGACCCATAGCCA

CTGGATTAAAAAAGATAGTTTGTCTGAAGCTGAGAGAGCGGCAGCCCAGGCTTATGCTAAAGAGAAAGGTTTGACCC

CTCCTTCGACAGACCATCAGGATTCAGGAAATACTGAGGCAAAAGGAGCAGAAGCTATCTACAACCGCGTGAAAGCA

GCTAAGAAGGTGCCACTTGATCGTATGCCTTACAATCTTCAATATACTGTAGAAGTCAAAAACGGTAGTTTAATCAT

ACCTCATTATGACCATTACCATAACATCAAATTTGAGTGGTTTGACGAAGGCCTTTATGAGGCACCTAAGGGGTATA

CTCTTGAGGATCTTTTGGCGACTGTCAAGTACTATGTCGAACATCCAAACGAACGTCCGCATTCAGATAATGGTTTT

GGTAACGCTAGCGACCATGTTCAAAGAAACAAAAATGGTCAAGCTGATACCAATCAAACGGAAAAAACCAAGCGAGGA

GAAACCTCAGACAGAAAAACCTGAGGAAGAAACCCCTCGAGAAGAGAAACCGCAAAGCGAGAAACCAGAGTCTCCAA

AACCAACAGAGGAACCAGAAGAATCACCAGAGGAATCAGAAGAACCTCAGGTCGAGACTGAAAAGGTTGAAGAAAAA

CTGAGAGAGGCTGAAGATTTACTTGGAAAAATCCAGGATCCAATTATCAAGTCCAATGCCAAAGAGACTCTCACAGG

ATTAAAAAATAATTTACTATTTGGCACCCAGGACAACAATACTATTATGGCAGAAGCTGAAAAACTATTGGCTTTAT

TAAAGGAGAGTAAGTAA

MKINKKYLAGSVAVLALSVCSYELGRHQAGQDKKESNRVAYIDGDQAGQKAENLTPDEVSKREGINAEQIVIKITDQ

GYVTSHGDHYHYYNGKVPYDAIISEELLMKDPNYQLKDSDIVNEIKGGYVIKVDGKYYVYLKDAAHADNIRTKEEIK

RQKQERSHNHGSGANDKAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYW

NGKQGSRPSSSSSYNANPAQPRLSENHNLTVTPTYHQNQGENISSLLRELYAKPLSERHVESDGLIFDPAQITSRTA

RGVAVPHGNHYHFIPYEQMSELEKRIARIIPLRYRSNHWVPDSRPEQPSPQSTPEPSPSPQPAPNPQPAPSNPIDEK

LVKEAVRKVGDGYVFEENGVSRYIPAKDLSAETAAGIDSKLAKQESLSHKLGAKKTDLPSSDPEFYNKAYDLLARIH

QDLLDNKGRQVDFEALDNLLERLKDVPSDKVKLVDDILAFLAPIRHPERLGKPNAQITYTDDEIQVAKLAGKYTTED

GYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKA

AKKVPLDRMPYNLQYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERPHSDNGF

GNASDHVQRNKNGQADTNQTEKPSEEKPQTEKPEEETPREEKPQSEKPESPKPTEEPEESPEESEEPQVETEKVEEK

LREAEDLLGKIQDPIIKSNAKETLTGLKNNLLFGTQDNNTIMAEAEKLLALLKESKZ

ID312

ATGGAGGGATTGGTTAGAGTGCATTTATTGCCTGTATTTGGCGATTACAAGCTATCTAAACTTACTACGCCTATTCT

TCAACAGCAAGTAAACAAATGGGCTGACAAGGCAAATAAAGGCGAAAAAGGGKGCATTTGCTAACTACTCTTTGCTCC

ATAACATGAATAAGCGTATTTTGAAATATGGCGTAGCTATCCAGGTAATACAATACAACCCAGCTAATGATGTCATC

GTTCCACGCAAACAGCAAAAAGAAAAGGCTGCTGTCAAATACTTAGACAACAAAGAATTAAAACAGTTTCTTGATTA

TTTAGATGCTCTGGATCAATCAAATTATGAGAACTTATTTGATGTTGTTCTGTATAAGACTTTATTGGCCACTGGTT

GCCGTATTAGTGAGGCTCTGGCTCTTGAATGGTCTGATATTGACCTAGAAAGCGGTGTTATCAGCATCAATAAGACA

CTAAACCGCTATCAGGAAATAAACTCACCTAAATCAAGCGCTGGTTATCGTGATATACCAATAGACAAAGCCACATT

ACTTTTACTGAAACAATACAAAAACCGTCAACAAATTCAGTCTTGGAAATTAGGCCGATCTGAAACAGTTGTATIC

CTGTATTTACGGAGAAATATGCTTATGCTTGTAACTTACGCAAACGCCTAAATAAGCATTTTGATGCTGCTGGAGTA

ACTAACGTATCATTTCATGGTTTCCGCCATACACATACTACTATGATGCTCTATGCTCAGGTTAGCCCGAAAGATGT

TCAGTATAGATTAGGCCACTCTAATTTAATGATCACTGAAAATACTTACTGGCATACTAACCAAGAGAATGCAAAAA

AAGCCGTCTCAAATTATGAAACAGCTATCAACAATTTATAA

MEGLVRVHLLPVFGDYKLSKLTTPILQQQVNKWADKANKGEKGAFANYSLLHNMNKRILKYGVAIQVIQYNPANDVI

VPRKQQKEKAAVKYLDNKELKQFLDYLDALDQSNYENLFDVVLYKTLLATGCRISEALALEWSDIDLESGVISINKT

LNRYQEINSPKSSAGYRDIPIDKATLLLLKQYKNRQQIQSWKLGRSETVVFSVFTEKYAYACNLRKRLNKHFDAAGV

TNVSFHGFRHTHTTMMLYAQVSPKDVQYRLGHSNTMITENTYWHTNQENAKKAVSNYETAINNLZ

Claims (18)

1. streptococcus pneumoniae protein or polypeptide, it has and is selected from following sequence:

MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDGSQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGY

VTSHGDHYHYYNGKVPYDALFSEELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINR

QKQEHVKDNEKVNSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLSASELAAAKAHLAGK

NMQPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELYDSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDH

YHFIPYSKLSALEEKIARMVPISGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAYIVR

HGDHFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRIIAEDESGFVMSHGDHNHYFFKKDLTEE

QIKVRKNI(SEQ?ID?NO.38)

2. the protein of claim 1 or polypeptide are provided with pure basically form.

With claim 1 or 2 in defined substantially the same protein or polypeptide.

4. the homologue or the derivative of defined protein or polypeptide in the claim 1 or 2.

5. the antigenicity and/or the immunogenic fragments of each described protein or polypeptide among the claim 1-4.

6. nucleic acid molecule, it contains following sequence or is made up of following sequence:

(i)ATGAAATTTAGTAAAAAATATATAGCAGCTGGATCAGCTGTTATCGTATCCTTGAGTCTATGTGCCT

ATGCACTAAACCAGCATCGTTCGCAGGAAAATAAGGACAATAATCGTGTCTCTIATGTGGATGGCA

GCCAGTCAAGTCAGAAAAGTGAAAACTTGACACCAGACCAGGTTAGCCAGAAAGAAGGAATTCAG

GCTGAGCAAATTGTAATCAAAATTACAGATCAGGGCTATGTAACGTCACACGGTGACCACTATCAT

TACTATAATGGGAAAGTTCCTTATGATGCCCTCTTTAGTGAAGAACTCTTGATGAAGGATCCAAACT

ATCAACTTAAAGACGCTGATATTGTCAATGAAGTCAAGGGTGGTTATATCATCAAGGTCGATGGAA

AATATTATGTCTACCTGAAAGATGCAGCTCATGCTGATAATGTTCGAACTAAAGATGAAATCAATCG

TCAAAAACAAGAACATGTCAAAGATAATGAGAAGGTTAACTCTAATGTTGCTGTAGCAAGGTCTCA

GGGACGATATACGACAAATGATGGTTATGTCTTTAATCCAGCTGATATTATCGAAGATACGGGTAAT

GCTTATATCGTTCCTCATGGAGGTCACTATCACTACATTCCCAAAAGCGATTTATCTGCTAGTGAATT

AGCAGCAGCTAAAGCACATCTGGCTGGAAAAAATATGCAACCGAGTCAGTTAAGCTATTCTTCAAC

AGCTAGTGACAATAACACGCAATCTGTAGCAAAAGGATCAACTAGCAAGCCAGCAAATAAATCTGA

AAATCTCCAGAGTCTTTTGAAGGAACTCTATGATTCACCTAGCGCCCAACGTTACAGTGAATCAGAT

GGCCTGGTCTTTGACCCTGCTAAGATTATCAGTCGTACACCAAATGGAGTTGCGATTCCGCATGGCG

ACCATTACCACTTTATTCCTTACAGCAAGCTTTCTGCCTTAGAAGAAAAGATTGCCAGAATGGTGCC

TATCAGTGGAACTGGTTCTACAGTTTCTACAAATGCAAAACCTAATGAAGTAGTGTCTAGTCTAGGC

AGTCTTTCAAGCAATCCTTCTTCTTTAACGACAAGTAAGGAGCTCTCTTCAGCATCTGATGGTTATAT

TTTTAATCCAAAAGATATCGTTGAAGAAACGGCTACAGCTTATATTGTAAGACATGGTGATCATTTC

CATTACATTCCA?AAATCAAATCAAATTGGGCAACCGACTCTTCCAAACAATAGTCTAGCAACACCTT

CTCCATCTCTTCCAATCAATCCAGGAACTTCACATGAGA?AACATGAAGAAGATGGATACGGATTTG

ATGCTAATCGTATTATCGCTGAAGATGAATCAGGTTTTGTCATGAGTCACGGAGACCACAATCATTA

TTTCTTCAAGAAGGAcTTGACAGAAGAGCAAATTAAGGTGCGCAAAAACATTTAG (SEQ ID NO.246) or its RNA equivalent

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) coding schedule 1 proteinic homologue, derivative or the fragments sequence of defining.

7. have among the claim of the being selected from 1-3 each described those, or described homologue of claim 4 or derivative, and/or the protein of the described fragments sequence of claim 5 or polypeptide are as immunogen and/or antigenic purposes.

8. an immunogenicity and/or antigenic composition, said composition contain one or more have among the claim of the being selected from 1-5 each described those, or described homologue of claim 4 or derivative, and/or described each segmental protein or the polypeptide of claim 5.

9. described immunogenicity of claim 8 and/or antigenic composition, said composition is a vaccine, perhaps is used for diagnostic test.

10. the described vaccine of claim 9, it contains one or more other components that is selected from vehicle, thinner, adjuvant etc.

11. a vaccine composition, it contains the described nucleotide sequence of one or more claims 6.

12. the method for a detection/diagnosis streptococcus pneumoniae, described method comprises makes each described protein or polypeptide among given the test agent and at least a claim 1-3, or described homologue of claim 4 or derivative, or the step of the described fragment contact of claim 5.

13. an antibody, each described protein or polypeptide among described antibody capable and the claim 1-3, or described homologue of claim 4 or derivative, or the described fragment combination of claim 5.

14. the defined antibody of claim 13, described antibody is monoclonal antibody.

15. the method for a detection/diagnosis streptococcus pneumoniae, described method comprise the step that given the test agent is contacted with at least a claim 13 or 14 defined antibody.

16. the method for a detection/diagnosis streptococcus pneumoniae, described method comprise the step that given the test agent is contacted with the defined nucleotide sequence of at least a claim 6.

17. measure among the claim 1-5 each described protein or whether polypeptide is the method for the antimicrobial target of potential for one kind, whether still described method comprises described protein of deactivation or polypeptide, and measure streptococcus pneumoniae survival.

18. can antagonism, inhibition or otherwise disturb as table 1-3 in the medicament of the function of defined protein or polypeptide or expression be used to prepare the purposes of medicine, described medicine can be used for treatment or prevention streptococcus pneumoniae infection.

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