CN101293921A - Streptococcus pneumoniae proteins and nucleic acid molecules - Google Patents

Abstract

The invention discloses novel protein antigens from Streptococcus pneumoniae, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described. The protein has any one sequence selected from the following sequence or from sequences shown by table 3: MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKSNPS AQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGM TLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNE DKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKK AAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVIL TQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE.

Description

Streptococcus pneumoniae proteins and nucleic acid molecule

It is 99811015.9 that the application of this division is based on application number, and the applying date is on July 27th, 1999, and denomination of invention is divided an application for the Chinese patent application of " streptococcus pneumoniae proteins and nucleic acid molecule ".

Technical field

The present invention relates to be derived from the protein of streptococcus pneumoniae (Streptococcus pneumoniae), this proteinic nucleic acid molecule of encoding, this nucleic acid and/or protein are as antigen/immunogenic purposes and the purposes in detection/diagnosis, and screening is as the method for the protein/nucleotide sequence of potential resisting-microorganism target.

Background of invention

Streptococcus pneumoniae often is called as streptococcus pneumoniae, and it is a kind of important pathogenic microorganism.In developing country and developed country, streptococcus pneumoniae infection occupies critical role all the time in human diseases, and the relevant expert had carried out commentary (Fiber, G.R., science, 265:1385-1387 (1994)) to this.It is believed that worldwide this microorganism is the modal pathogenic bacterium of acute respiratory infection, estimate to cause 100 ten thousand death of child every year, great majority wherein are the children (Stansfield of developing country, S.K., paediatrics transmissible disease, 6:622 (1987)).In the U.S., the someone proposes (Breiman etc., Arch.Intern.Med., 150:1401 (1990)) streptococcus pneumoniae is still the modal pathogenic bacterium of bacterial pneumonia, children, and the elderly and suffer from the easy infection disease, as alienia disease, heart trouble, tuberculosis and ephrosis, diabetes, crapulent patient, or suffering from immunosuppressant disease, among the patient as AIDS, the sickness rate of bacterial pneumonia is high especially.Therefore suffer from an inflammation of the lungs coccus septicemia and (suffer from) meningitic risk of these crowds is higher, the risk that the coccus that therefore dies of pneumonia infects is bigger.Streptococcus pneumoniae also is the pathogenic bacterium of otitis media and sinusitis paranasal sinusitis, and these two kinds of diseases are popular infection always in the children of developed country, and bring very big cost.

Recently, the pneumococcal appearance of penicillin-resistance makes to the needs of the strategy of effective prevention pneumococcal infection urgent day by day.It is reported, in the 13 tame hospitals in 12 states of the U.S., 6.6% streptococcus pneumoniae strain isolated has resistance to penicillin, some strain isolateds are also to other microbiotic, comprise that third generation S-Neoral has resistance (Schappert, S.M., the population and the healthy state statistic data at national Centre for Disease Control/healthy state statistics center, 214:1 (1992)).In some hospital, the ratio of penicillin resistance higher (reaching 20%) (Breiman etc., American Medical Association's will, 271:1831 (1994)).Because pneumococcal penicillin resistance is to keep better curative effect after decades at penicillin, and is emergent in the recent period, so these discoveries make us panic.

In view of above-mentioned reason, must be devoted to the improvement prevention, control, the method for diagnosis or treatment streptococcus pneumoniae disease.

Adopted several different methods to provide the prevention pneumococcal infection used vaccine.It can be divided into different serotype (at least 90 kinds) according to the polysaccharide pod membrane structure around the microorganism, produce a plurality of difficult problems thus.Vaccine at single serotype is invalid to other serotype, this means that vaccine must comprise that the polysaccharide antigen of all serotypes could be in most of the cases effective.Someone finds (determining serotype separately when capsular polysaccharide; and be main protective antigen) be purified and when the vaccine; can not in the children's body below two years old, induce protection antibody to reply reliably, and this age group invasive pneumococcal infection and the highest crowd of meningitic sickness rate exactly.

Use the improvement of kantigen method to rely on polysaccharide and proteinic puting together, thereby reply the feature that depends on the T-cell and obtain the enhanced immunne response by giving especially.This method has been used to develop for example vaccine of anti influenza influenzae (Haemophilus influenzae).Yet, be still bone of contention about multiple polysaccharide vaccine with based on the cost of the vaccine of conjugate.

The third method is to seek other to have the antigen component of the potentiality that become candidate vaccine.In the present invention, we provide a histone matter antigen, and described antigen is secretion/output protein.

Therefore, first aspect the invention provides streptococcus pneumoniae proteins or polypeptide, and it has and is selected from the sequence shown in the table 2.

Protein of the present invention that is provided or polypeptide can be pure basically forms.For example, can be to be substantially free of other proteinic form.

In preferred embodiments, provide protein or polypeptide with aminoacid sequence shown in the table 3.

The present invention includes any protein by nucleic acid sequence encoding shown in this paper table 1.

As described herein, protein of the present invention and polypeptide can be used as antigenic substance.Described material can be " antigenic " and/or " immunogenic ".Usually, " antigenic " is meant that in fact protein or polypeptide can be used to produce antibody, perhaps can induce antibody response in subject." immunogenic " is meant that protein or polypeptide can cause protective immune response in subject.Therefore, under latter event, protein or polypeptide can not only produce antibody response, can also produce not the immunne response based on antibody.

Those skilled in the art should understand that the homologue of protein of the present invention or polypeptide or derivative also can be used for context of the present invention, promptly as antigenic/immunogenic material.Therefore, the present invention also comprises for example having one or more interpolations, disappearance, the protein or the polypeptide of replacement etc.In addition, can be with the amino acid of a kind of aminoacid replacement another kind similar " type ".For example, replace another kind of hydrophobic amino acid with a kind of hydrophobic amino acid.Can service routine (as the CLUSTAL program) comparing amino acid sequence.This program can compare aminoacid sequence, and inserts in arbitrary sequence when suitable and find the optimal sequence contrast at interval.Can correlated amino acid identity of calculating optimum sequence or similarity (identity adds the conservative property of amino acid type).Can contrast one section the longest similar sequences and specify such as the program of BLASTx and meet value.Therefore, can obtain comparative result, can find several similaritys zone therein, they have different score values separately.The present invention wishes to carry out this analysis of two types.

For homologue and derivative, more inessential with the identity degree of protein described herein or polypeptide, importantly homologue or derivative should keep antigenicity or the immunogenicity of streptococcus pneumoniae.Yet, provide that to have the homologue or a derivative (as discussed above) of at least 60% similarity comparatively suitable with protein described herein or polypeptide, homologue or derivative with at least 70% similarity preferably are provided, homologue or derivative with at least 80% similarity more preferably are provided, most preferably provide to have at least 90% or even the homologue or the derivative of 95% similarity.

In another approach, homologue or derivative can be fusion roteins, and the moiety of wherein mixing is by for example mark desired protein or polypeptide make purifying become easier effectively.Must remove " marker ", perhaps, in fact fusion rotein self should keep enough antigenicities so that it is useful.

In another aspect of this invention, provide protein of the present invention or polypeptide, or the antigenicity/immunogenic fragments of its homologue or derivative.

With regard to protein described herein or polypeptide, or the fragment of its homologue or derivative, situation is slightly different.As everyone knows, can screen antigen protein or polypeptide, promptly be responsible for the antigenicity or the immunogenic zone of protein or polypeptide to identify epitope regions.It is well-known in the art carrying out this method for screening, and therefore, fragment of the present invention should comprise one or more described epitope regions, perhaps enough similar to keep its antigenicity/immunogenicity to described zone.Therefore, for fragment of the present invention, the identity degree may be incoherent because they can with protein as herein described or polypeptide, the specific part 100% of homologue or derivative is identical.Equally, main problem is that fragment must keep antigenicity/immunogenicity.

Therefore, for the homologue of deriving and obtaining by protein or polypeptide, derivative and fragment, importantly they should have its derived from described protein or the incomplete antigen/immunogenicity at least of polypeptide.

Can use gene clone technology that pure basically protein of the present invention is provided.Described technology is disclosed in for example Sambrook etc., molecular cloning, the 2nd edition, press of cold spring harbor laboratory (1989).Therefore, fourth aspect the invention provides nucleic acid molecule, and it contains following sequence or is made up of following sequence:

(i) any dna sequence dna shown in the table 1 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) the coding schedule 1 proteinic homologue that limits, derivative or fragments sequence.

The 5th aspect the invention provides nucleic acid molecule, and it contains following sequence or is made up of following sequence:

(i) any dna sequence dna shown in the table 4 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) the coding schedule 4 proteinic homologue that limits, derivative or fragments sequence.

Nucleic acid molecule of the present invention comprises a plurality of this sequences and/or fragment.Those skilled in the art should understand the neomorph that the present invention includes the new specific nucleic acid molecule that this paper exemplifies.The present invention includes this variant.Described variant can be natural variant, for example the variant that produces owing to the bacterial strain variation.For example, comprise interpolation, replace and/or disappearance.In addition, particularly when using the microbial expression system, people wish by utilizing the codon of expressing known preference use in the used specific organism to transform nucleotide sequence.Therefore, also comprise synthetic or non--natural variant in the scope of the present invention.

Sequence that the given RNA molecule of above used term " RNA equivalent " expression has and the sequence complementation of given dna molecular (allowing in the RNA genetic code, to substitute " T ") with " U ".

When relatively nucleotide sequence is with mensuration homology or identity degree, for example can use relatively two sequences of BESTFIT and GAP (all deriving from Wisconsin Genetics Computer Group (GCG) software package) BESTFIT program, produce the optimal sequence contrast of similar section.GAP can make sequence compare along its total length, and inserts in arbitrary sequence when suitable and find the optimal sequence contrast at interval.In the context of the present invention, when the identity of nucleotide sequence is discussed, be suitable for by carrying out sequence along full length sequence to comparative sequences recently.

Preferred substantially the same sequence and described sequence has at least 50% sequence identity, more preferably has at least 75% sequence identity, more preferably has at least 90% or at least 95% sequence identity.In some cases, sequence identity can be 99% or more than.

Preferably, term " substantially the same " expression: for the identity degree of the nucleotide sequence of described sequence and prior art, the identity degree of described sequence and arbitrary sequence described herein is higher.

Yet, should be noted that when nucleic acid sequence encoding of the present invention during to the new gene product of small part, comprise all possible sequence of encoding gene product or its new part in the scope of the invention.

Nucleic acid molecule can be the form of isolating form or reorganization.It can be mixed carrier, carrier can be impregnated in the host.Described carrier and suitable host constitute another aspect of the present invention.

Therefore, for example,, can identify the gene of streptococcus pneumoniae by using probe based on the nucleotide sequence that this paper provided.Use Restriction Enzyme can downcut these genes, be cloned into carrier, again carrier is imported suitable host to express.

By the partial sequence complementary suitable probe of use, can from streptococcus pneumoniae, obtain nucleic acid molecule of the present invention with nucleic acid molecule.Can use Restriction Enzyme or supersound process technology to obtain suitably big or small fragment to be used as probe.

Perhaps, can use the required nucleotide sequence of round pcr amplification.Therefore, can use two primers of sequence data design provided herein to be used for PCR, thereby make required sequence, comprise that complete genome or its fragment by target, are increased immediately high-levelly.Under the normal circumstances, a primer has high-caliber specificity to first sequence on the chain that is positioned at dna molecular, another primer has high-caliber specificity to second sequence that is positioned on the dna sequence dna complementary strand, the complementary sequence of described second sequence and first sequence segment distance of being separated by.

It is long that primer generally is at least 15 to 25 Nucleotide.

Another kind method is to use chemosynthesis, and this method can be carried out automatization.Can chemosynthesis relatively short sequence, be interconnected to form long sequence again.

On the other hand, the invention provides immunogenicity/antigenic composition, said composition contains one or more and has protein or polypeptide or its homologue or the derivative of sequence that is selected from sequence shown in the table 2-4, and/or any the fragment in them.In preferred embodiments, immunogenicity/antigenic composition is a vaccine, perhaps can be used for diagnostic test.

With regard to vaccine, it can comprise the vehicle of suitable interpolation, thinner, adjuvant etc.A plurality of specific exampless are well-known in the art.

Nucleotide sequence shown in also can use table 1 prepares so-called dna vaccination.Therefore, the present invention also provides the vaccine composition that contains one or more nucleotide sequences defined herein.Existing people described the purposes of this dna vaccination in this area, and example is seen Donnelly etc., and 15:617-648 (1997) is commented in immunity academic year.

As mentioned above, in the method for detection/diagnosis streptococcus pneumoniae, can use protein as herein described or polypeptide, its homologue or derivative, and/or any the fragment in them.Detect the anti-described proteinic antibody that exists in the subject, set up aforesaid method based on this.Therefore, the invention provides the method for detection/diagnosis streptococcus pneumoniae, described method comprises makes given the test agent and at least a protein as herein described or its homologue, the step of derivative or fragment contact.Preferred sample is a biological sample, as derives from experimenter's to be measured tissue sample or blood sample or saliva.

In another approach, can use protein as herein described, or its homologue, derivative and/or fragment produce antibody, and conversely, described antibody can be used for detecting antigen, thereby can detect streptococcus pneumoniae.Described antibody constitutes another aspect of the present invention.Antibody in the scope of the invention can be mono-clonal or polyclonal antibody.

When with protein as herein described, or its homologue, when derivative or fragment are injected in suitable animal host (as mouse, rat, cavy, rabbit, sheep, goat or the monkey) body, can make animal produce polyclonal antibody by stimulating antibody to generate.In case of necessity, can use adjuvant and protein simultaneously.Well-known adjuvant comprises freund's adjuvant (complete and Freund) and aluminium hydroxide.Then, utilize antibody and combination of proteins described herein to get final product antibody purification.

Monoclonal antibody can be produced by hybridoma.Can form hybridoma by the splenocyte that merges myeloma cell and the required antibody of generation with the clone that forms infinite multiplication.Therefore, can use well-known Kohler ﹠amp; Milstein technology (nature, 256 (1975)) or the technology of on the basis of this technology, changing.

At present, production has been the mature technology of this area with the technology of specific polypeptides bonded mono-clonal and polyclonal antibody.Relevant discussion can be referring to the immunology textbook of standard, Roitt etc. for example, immunology, the 2nd edition (1989), Churchill Livingstone, London.

Except complete antibody, the present invention also comprises the derivative of this antibody, and described derivative can combine with protein as described herein etc.Therefore, the present invention includes antibody fragment and synthetic construct.The example of antibody fragment and synthetic construct can be referring to Dougall etc., Tibtech 12372-379 (in September, 1994).

Antibody fragment comprises for example Fab, F (ab ') ₂With the Fv fragment.Fab fragment (these fragments are discussed in [document are the same] such as Roitt).Can modify the Fv fragment is known as strand Fv (scFv) molecule with generation synthetic construct.This molecule comprises and V _hAnd V _lDistinguish covalently bound peptide linker, it is contributed to some extent to the stability of molecule.Operable other synthetic construct comprises the CDR peptide, and they are to contain antigen-in conjunction with the synthetic peptide of determinant.Also can use simulating peptide, these molecules are the limited organic ring of conformation normally, and it can simulate the structure of CDR ring, and comprise can with the side chain of AI.

Synthetic construct comprises chimeric molecule.Therefore, for example, also comprise humanization (or primateization) antibody or derivatives thereof in the scope of the invention.The example of humanized antibody is the antibody with people's framework region and rodent hypervariable region.Producing the method for chimeric antibody can be referring to for example Morrison etc., PNAS, and 81,6851-6855 (1984) and Takeda etc., naturally, and 314,452-454 (1985).

Synthetic construct also comprises the molecule that contains other moiety, and described other composition can be molecule some desired characteristic except that the antigen binding characteristic are provided.For example, described moiety can be marker (for example fluorescence or a radio-labeling).Perhaps, also can be pharmaceutically active agents.

The antibody or derivatives thereof can be used for detection/diagnosis streptococcus pneumoniae.Therefore, on the other hand, the invention provides the method for detection/diagnosis streptococcus pneumoniae, described method comprises the step that given the test agent is contacted with antibody, described antibody capable is in conjunction with one or more protein as herein described, or its homologue, derivative and/or fragment.

In addition, can use so-called " affine body ".These affine bodies are conjugated protein (Nord etc.) that are selected from the combinatorial library of alpha-helix bacterial receptor structural domain.Therefore, can use the combinatorial library method select can with different target protein specificity bonded small protein matter structural domains.

Obviously, can use nucleotide sequence detection/diagnosis streptococcus pneumoniae as herein described.Therefore, on the other hand, the invention provides the method for detection/diagnosis streptococcus pneumoniae, described method comprises makes given the test agent contact with at least a nucleotide sequence as herein described.Preferred sample is a biological sample, as derives from experimenter's to be measured tissue sample or blood sample or saliva.Before being used for method of the present invention, can carry out pre-treatment to sample.Therefore, for example, can handle sample to extract DNA.Use the nucleic acid that detects streptococcus pneumoniae based on the dna probe of nucleotide sequence described herein (being generally the fragment of this sequence) then.

In others, the invention provides:

(a) the immunization experimenter is in case the method for streptococcus pneumoniae, and described method comprises to the experimenter uses protein of the present invention or polypeptide, or derivatives thereof, homologue or fragment, or the step of immunogenic composition of the present invention;

(b) the immunization experimenter is in case the method for streptococcus pneumoniae, and described method comprises the step of using nucleic acid molecule defined herein to the experimenter;

(c) method of prevention or treatment streptococcus pneumoniae infection, described method comprises to the experimenter uses protein of the present invention or polypeptide, or derivatives thereof, homologue or fragment, or the step of immunogenic composition of the present invention;

(d) method of prevention or treatment streptococcus pneumoniae infection, described method comprises the step of using nucleic acid molecule defined herein to the experimenter;

(e) be used to detect/diagnose the test kit of streptococcus pneumoniae infection, it comprises one or more protein of the present invention or polypeptide, or its homologue, derivative or fragment, or antigenic composition of the present invention; With

(f) be used to detect/diagnose the test kit of streptococcus pneumoniae infection, it comprises the nucleic acid molecule that one or more are defined herein.

Even we have identified one group of important protein matter, described protein is the potential target of antimicrobial therapy.Whether yet still must measure each protein is that microbial survival is necessary.Therefore whether still, the present invention also provides and has measured protein described herein or whether polypeptide is the method for the antimicrobial target of potential, and described method comprises the described protein of deactivation, and measure streptococcus pneumoniae survival in external or body.

Whether the proteinic proper method of deactivation is to carry out selected gene knockout, promptly stop protein expression and measure to cause lethality to change.The proper method that carries out described gene knockout is described in Li etc., institute of NAS newspaper, 94:13251-13256 (1997).

Last aspect, the invention provides can antagonism, suppress or otherwise disturb the medicament of the function of protein of the present invention or polypeptide or expression to be used to prepare the purposes of medicine, described medicine can be used for treatment or prevention streptococcus pneumoniae infection.

Describe the present invention hereinafter with reference to embodiment, embodiment should not regarded as and limit the present invention by any way.The accompanying drawing of reference is among the embodiment:

Fig. 1: the result who demonstrates multiple dna vaccination test; Particularly, use streptococcus pneumoniae challenge trial 2,7 and 8 the screening of information biology dna vaccination positive findings and

Fig. 2: the result who demonstrates other dna vaccination tests; Particularly, use the positive findings of the information biology dna vaccination screening of streptococcus pneumoniae challenge trial 9-11.

Embodiment 1

Just (TIGR, Rockville, MD, the U.S.) carries out the gene order-checking of 4 type streptococcus pneumoniaes at the genome research center.Up to the present, complete sequence remains unfulfilled or discloses.On November 21st, 1997, the TIGR center has discharged some dna sequence dnas with overlap group's form, and this can not accurately reflect completed sequence.Can from the network address (www@tigr.org) at TIGR center, download these overlaps group.We have downloaded these overlaps group, use application program GCGToBLAST (Wisconsin Package Version 9.1, GeneticsComputer Group (GCG), Madison, the U.S.) to set up local data base.Available FastA and TfastA method are retrieved this database and (are used the method (institute of NAS newspaper, 85:2444-2448 (1988)) of Pearson and Lipman.

Use FastA and TfastA method, retrieve and infer leader sequence or anchor sequence signature in the local streptococcus pneumoniae database.Use correlated series inquiry (interrogate) newer sequence.They are:

(i) the streptococcus pneumoniae leader sequence of having described (deriving from protein N anA, NanB, LytA, PapA, pcpA, PsaA and PspA);

The (ii) leader sequence of Lactococcus lactis (Lactococcus lactis) secretary protein Usp45;

(iii) retrieval (i) and the (ii) new vacation plan leader sequence of gained;

The (iv) LPxTG of anchorage unit, it is the common trait of a lot of gram positive bacterium surface proteins, but this primitive by participating in the proteic mechanism anchor of Sortase complex body.

The example of this method is provided hereinafter with reference to the sequence that is derived from database (seeing Table I).

The proteinic protein leader sequence of different known output is used as the starting point of retrieving above-mentioned local streptococcus pneumoniae database.At general database,, among the Swissprot etc. the false albuminoid of finding by this retrieval is carried out the Blast retrieval then as EMBL.Reservation is also explained still unknown pneumoprotein matter.Use the TfastA method then, use new potential protein leader sequence to retrieve once more as probe.

Embodiment 2:DNA vaccine test

PcDNA3.1+ is as dna vaccine vector

pcDNA3.1+

Selected carrier as dna vaccine vector is pcDNA3.1 (Invitrogen) (is actually pcDNA3.1+, all use the forward carrier in all cases, but this paper is referred to as pcDNA3.1).In the literature, this carrier extensively and successfully has been used as host's carrier to detect the situation (Zhang etc., Kurar and Splitter, Anderson etc.) of vaccine candidate gene initiation at the pathogenic agent provide protection.This carrier is designed to carry out high level in mammalian cell stable and non--transient expression that duplicates.PcDNA3.1 contains the ColE1 replication orgin, duplicates and grows so that carry out high copy number in intestinal bacteria.Also can clone and detect a lot of genes fast and effectively conversely.The pcDNA3.1 carrier has a large amount of cloning sites, also contains the amicillin resistance encoding gene that helps clonal selection and the human cytomegalic inclusion disease virus of high level expression recombinant protein (CMV) immediate early promoter/enhanser effectively.In the various kinds of cell type that comprises myocyte and immunity (antigen presentation) cell, the CMV promotor is the strong virus promotor.This is most important for best immunne response, because do not know still that at present which kind of cell type is most important for producing protective response in vivo.The T7 promotor of multiple clone site upstream can make required modified inset effective expression, and can be at the external clone gene of transcribing on sense orientation.

Zhang, D., Yang, X., Berry, J.Shen, C., McClarty, G and Brunham, R.C. (1997), " carry out dna immunization with the major outer membrane protein gene and can induce the acquired immunity power that infects at chlamydia trachomatis (mouse pneumonia), " infects and immunity, and 176,1035-40.

Kurar, E and Splitter, G.A (1997), " nucleic acid immunization of Bacillus abortus rrna L7/L12 gene causes immunne response ", vaccine, 15,1851-57.

Ander, R., Gao, X.M., Papakonstantinopoulou, A., Roberts, M and Dougan, G (1996), " with the immunne response after the segmental dna immunization mouse of coding tetanus toxin C " infects and immunity, and 64,3168-3173.

The preparation dna vaccination

Be each the required gene design Oligonucleolide primers that uses the LEEP system to obtain.Overhaul each gene, if possible, should design primer and make its target it is believed that the only Gene Partial of the proteinic maturing part of encoding gene.We wish that when expressing those sequences of expressing the maturing part of the target gene protein matter of only encoding can help proteinic correct folding in mammalian cell.For example, in most of the cases, should design primer so that be cloned into the final amplified production of pcDNA3.1 expression vector and not contain the terminal signal peptide sequence of the N-that infers.Signal peptide via protein output pathway guiding cytolemma, downcuts signal peptide at this by signal peptidase I (if lipoprotein is signal peptidase I I) with polypeptide precursor.Therefore, no matter be presented on bacterium surface or secreted, signal peptide does not constitute arbitrary part of mature protein.When the terminal leader peptide sequences of N-when not being apparent immediately, should design primer with the whole gene order of target with clone in pcDNA3.1 and finally express.

Yet, said that proteinic further feature also can influence the expression of soluble protein and presents.In the process of design oligonucleotides, should in the gene of coding desired protein, get rid of the dna sequence dna of these features of coding.These features comprise:

1.LPXTG the cell walls anchor primitive.

2.LXXC lipoprotein binding site.

3. hydrophobic C-end structure territory.

4. when not having terminal signal peptide of N-or LXXC, should remove terminator codon.

5. when not having hydrophobicity C-end structure territory or LPXTG primitive, should remove terminator codon.

Be interested each gene design suitable substance P CR primer, when these primers of design, should from gene, remove any and All Ranges of the above-mentioned feature of coding.Primer is designed to have suitable Restriction Enzyme site, and then conservative thereafter Kozak nucleotide sequence, and that (in all cases) uses is GCCACC.The Kozak sequence helps eucaryon rrna identification homing sequence and is positioned at the ATG initiator codon of required gene inset upstream.For example, use the forward primer in BamHI site initial with GCGGGATCCGCCACCA TG, a bit of sequence of required gene 5 ' end is followed in the back.Design reverse primer with compatible with forward primer, and compatible with the NotI restriction site (this site is TTGCGGCCGC) of 5 ' end in all cases.

The PCR primer

Following PCR primer is designed to the required truncated gene that increases.

ID210

Forward primer 5 ' CGGATCCGCCACCATGTCTTCTAATGAATCTGCCGATG3 '

Reverse primer 5 ' TTGCGGCCGCCTGTTTAGATTGGATATCTGTAAAGACTT3 '

4172.5

Forward primer 5 '

CGCGGATCCGCCACCATGGATTTTCCTTCAAATTTGGAGG?3′

Reverse primer 5 ' TTGCGGCCGCACCGTACTGGCTGCTGACT 3 '

ID211

Forward primer 5 '

CGGATCCGCCACCATGAGTGAGATCAAAATTATTAACGC?3′

Reverse primer 5 ' TTGCGGCCGCCGTTCCATGGTTGACTCCT 3 '

4197.4

Forward primer 5 ' CGCGGATCCGCCACCATGTGGGACATATTGGTGGAAAC3 '

Reverse primer 5 ' TTGCGGCCGCTTCACTTGAGCAAACTGAATCC 3 '

4122.1

Forward primer 5 '

CGCGGATCCGCCACCATGTCACAAGAAAAAACAAAAAATGAA?3′

Reverse primer 5 ' TTGCGGCCGCATCGACGTAGTCTCCGCC 3 '

4126.7

Forward primer 5 '

CGCGGATCCGCCACCATGCTGGTTGGAACTTTCTACTATCAAT?3′

Reverse primer 5 ' TTGCGGCCGCAACTTTCGTCCCTTTTTGG 3 '

4188.11

Forward primer 5 ' CGCGGATCCGCCACCATGGGCAATTCTGGCGGAA 3 '

Reverse primer 5 ' TTGCGGCCGCTTGTTTCATAGCTTTTTTGATTGTT 3 '

ID209

Forward primer 5 '

CGCGGATCCGCCACCATGCTATTGATACGAAATGCAGGG?3′

Reverse primer 5 ' TTGCGGCCGCAACATAATCTAGTAAATAAGCGTAGCC 3 '

ID215

Forward primer 5 ' CGCGGATCCGCCACCATGACGGCGACGAATTTTC 3 '

Reverse primer 5 ' TTGCGGCCGCTTAATTCGTTTTTGAACTAGTTGCT 3 '

4170.4

Forward primer 5 '

CGCGGATCCGCCACCATGGCTGTTTTTCTTCGCTATCATG?3′

Reverse primer 5 ' TTGCGGCCGCTTTCTTCAACAAACCTTGTTCTTG 3 '

4193.1

Forward primer 5 '

CGCGGATCCGCCACCATGGGTAACCGCTCTTCTCGTAAC?3′

Reverse primer 5 ' TTGCGGCCGCGCTTCCATCAAGGATTTTAGC 3 '

The clone

Isolation of genomic DNA from the 4 type S. pneumoniae strains 11886 that derive from national typical culture collection center, as template through pcr amplification inset and flanking sequence with above-mentioned feature.With suitable Restriction Enzyme cutting PCR product, use conventional Protocols in Molecular Biology to be cloned into the multiple clone site of pcDNA3.1.Cultivate through the suitably required gene clone of mapping, the extensive separation quality grain of use Plasmid Mega test kit (Qiagen) (＞1.5mg).Carry out restriction map analysis and order-checking by about 700 base pairs, confirm that further the success of gene is cloned and kept 5 ' clone's joint of each extensive goods of each construct.

Bacterial strain confirms

Use 4 type bacterial strains in the method for clone and attack, the streptococcus pneumoniae genome of this bacterial strain is checked order.The homogeneous laboratory strains freeze-drying ampoule of 4 type S. pneumoniae strains 11886 derives from national typical DSMZ.Open ampoule, with 0.5ml tryptone beans peptone meat soups (0.5% glucose, 5% blood) suspension culture again.The culture suspension that goes down to posterity in 10ml tryptone beans peptone meat soup (0.5% glucose, 5% blood) is in 37 ℃ of static incubated overnight.This culture of line is rule on the blood agar inclined-plane to check pollutent and to confirm survival on 5% blood agar flat board, uses all the other cultures to prepare 20% glycerine original seed.Slant culture is delivered to the public health experimental center, and verified serotype is 4 types.

On 5% blood agar flat board the line NCTC11886 the glycerine original seed, in 37 ℃ at CO ₂Incubated overnight in the gas tank.Prepare fresh streak culture and confirm optochin susceptibility.

Streptococcus pneumoniae is attacked

Through go down to posterity streptococcus pneumoniae culture 1 time of mouse, from the blood of infection animal, collect streptococcus pneumoniae, in meat soup, be cultured to predetermined viable count and be about 10 ⁹Cfu/ml, freezing then, thus prepare the standard inoculation frozen cultures of 4 type streptococcus pneumoniaes.The flow process of preparation is as follows:

Line pneumococcus culture and confirm its identity → above-mentioned flat board cultivate the overnight culture of 4-5 bacterium colony → with pneumococcal overnight culture through animal passage of animal passage pneumococcus culture (the intraperitoneal injection heart is got blood to collect) → cultivate → by cultivate through the overnight culture of animal passage whole day culture (to predetermined optical density) and in-70 ℃ freezing-this is that the inoculum of the limit → thawings an equal portions standard of standard carries out all subsequently attacks to carry out viable count → Application standard inoculum with the standard inoculation thing of measuring effective dose (being referred to as the virulence detection tests) → use effective dose.

With 500 times of the inoculum of equal portions standard dilutions, and be used to inoculate mouse with PBS.

Using the slight anesthetized mice of haloalkane, is 1.4 * 10 with dosage then ⁵The streptococcus pneumoniae of cfu is applied to the nasal cavity of each mouse, and the eupnea of mouse will help taking in streptococcus pneumoniae, allows mouse carry on the back recumbency Wait-to-Restore down.

The Streptococcus pneumoniae vaccine test

(Harlan UK) uses DNA and carry out vaccine test in mouse CBA/ca mouse by giving for 6 ages in week.The mouse for the treatment of immunization is divided into 6 groups, and every group is carried out immunization with reorganization pcDNA3.1+ plasmid DNA, contains required particular target gene order in the described plasmid DNA.100 μ g are dissolved in the preceding tibialis (every leg 50 μ l) of DNA intramuscularly to two leg among the Dulbecco PBS (Sigma) altogether.The identical method of 4 weeks back use is carried out booster immunization.In order to compare, in all vaccine tests, all comprise control group.These control groups or without the animal of immunity, or only used the animal of non-reorganization pcDNA3.1+DNA (false immunity) by time course same as described above.Immunization is after 3 weeks, with attacking all mouse groups in streptococcus pneumoniae serotype 4 (bacterial strain NCTC11886) nose of lethal dose for the second time.Monitor the number of the bacterium of using through the inoculum of serial dilution by tiling inoculation on 5% blood agar flat board.The problem of immunization is in the nose: in some mouse, inoculum comes up as frothing from the nostril, is noticing this problem in the table as a result, and this problem has been taken into account when calculating.More unconspicuous problem is that every mouse may swallow a part of inoculum.Suppose that for every mouse the amount of being swallowed is identical, will reach average in seeded process.Yet employed sample is less, and this problem will produce remarkably influenced to some experiments.After infection 3 or 4 days, kill after the attack still all mouse of survival.In course of infection, induce with streptococcus pneumoniae in the mouse attacked of monitoring-the relevant symptom development of outbreak of disease.Typical symptoms comprises piloerection successively, and the protuberance figure of Zeng Jiaing is flowed out movement in the eyes gradually, and is drowsiness and be reluctant to move.The symptom in later stage is consistent with the generation of moribund condition usually, and the mouse of rejecting moribund condition is so that they no longer suffer misery.It is believed that these mouse are at death's door, use the rejecting time to determine that the survival time is to carry out statistical analysis.When finding dead mouse, the survival time is by as being to think the last time point that mouse still lives through monitoring.

Result's explanation

If cloned and be used for the provide protection that any dna sequence dna of above-mentioned attack experiment can create antagonism and attack, be positive findings.Provide protection is regarded as dna sequence dna can produce significant provide protection (confidence level is 95% (p＜0.05)) on the statistics; with the inadequate or approaching significant provide protection of using Mann-Whitney to find; or demonstrate some protective features, one or many irrelevant mouse are for example arranged or because occur dead time lengthening first.When we thought that associated problem that some results are used intranasal infection make smudgy, being considered to the potential positive findings near remarkable or non-significant result was acceptable.

Vaccine test 2,7 and 8 (see figure 1) as a result

^*-when by this dosage immunity, there is sub-fraction to be emerged as frothing, therefore may not accept whole inoculums.

T-stops when experiment finishes, and does not have infection symptoms.

The survival time of the incomplete dosage that the numeral in the bracket-do not consider is adopted.

P value 1 refers to and the significance test of comparing without the contrast of immunity.

Statistical analysis

Test 2-compares with the contrast without immunization, and the ID210 immune group has long mean survival time, but this result is not very remarkable statistically.

Test 7-compares with the contrast without immunization, and 4172.5 immune group demonstrate the longer survival time, but this difference does not have significance,statistical.

Test 8-compares with the contrast without immunization, and the survival time of ID211 immune group is significantly longer.4197.4 4122.1 and 4126.7 immune group demonstrate than without the longer mean survival time of immune group, but this result is not remarkable statistically.4197.4 with 4126.7 groups of time retardations that occur death first, 4122.1 groups demonstrate 1 irrelevant result.

Streptococcus pneumoniae is attacked the (see figure 2) as a result of dna immunization test 9-11

^*-when by this dosage immunity, there is sub-fraction to be emerged as frothing, therefore may not accept whole inoculums.

T-stops when experiment finishes, and does not have infection symptoms.

The survival time of the incomplete dosage that the numeral in the bracket-do not consider is adopted.

P value 1 refers to and the significance test of comparing without the contrast of immunity.

P value 2 refers to and the significance test of comparing through the contrast of pcDNA3.1+ immunity.

Statistical analysis

Although the test 9-nonsensical statistically, compare with control group without immunity, 4188.11 and the ID209 immune group have perceptible higher mean survival time really.

The test 10-compare with the pcDNA3.1+ immune group, without the control group survival time of immunity significantly longer.Compare with false immune group, ID215 and 4170.4 immune group demonstrate the longer survival time (p=0.0168 and 0.0316) with statistical significance, but can not with compare without immune group.

Test 11-4193.1 immune group is optimal, and its survival time is than pcDNA3.1+ immune group on average long 6.5 hours, and than without immune group leader 6 hours, but this is not remarkable on statistics as a result.

Table 1

4101.1

ATGGAAGAGTTAGTGACCTTAGATTGTTTGTTTATTGACAGAACTAAGATTGAAGCCAATGCCAACAAGTATAGTT

TTGTGTGGAAGAAAACGACAGAGAAATTCTCCGCCAAACTTCAAGAACAGATACAGGTCTATTTTCAAGAAGAAA

TCACTCCCCTTCTGATTAAATATGCCATGTTTGATAAGAAACAAAAGAGAGGGTATAAAGAGTCAGCTAAAAACT

TAGCGAATTGGCACTATAATGACAAGGAGGATAGCTACACACATCCTGATGGCTGGTATTATCGTTTTCACCATAC

CAAATATCAGAAAACACAGACAGACTTTCAACAAGAAATCAAGGTTTACTACGCCGACGAACCTGAATCAGCCCC

TCAAAAGGGACTGTATATGAACGAACGCTATCAAAACTTGAAAGCTAAAGAATGTCAGGCGCTTTTATCTCCCCA

AGGTAGACAGATTTTCGCTCAACGCAAGATTGATGTGGAACCTGTCTTTGGGCAGATAAAGGCTTCTTTGGGTTAC

AAGAGATGTAATCTGAGAGGGAAGCGTCAAGTGAGAATTGACATGGGATTGGTACTTATGGCCAATAACCTCCTA

AAATATAGTAAAATGAAATAA

4101.3

ATGGGGAAAGGCCATTGGAATCGGAAAAGAGTTTATAGCATTCGTAAGTTTGCTGTGGGAGCTTGCTCAGTAATG

ATTGGGACTTGTGCAGTTTTATTAGGAGGAAATATAGCTGGAGAATCTGTAGTTTATGCGGATGAAACACTTATTA

CTCATACTGCTGAGAAACCTAAAGAGGAAAAAATGATAGTAGAAGAAAAGGCTGATAAAGCTTTGGAAACTAAA

AATATAGTTGAAAGGACAGAACAAAGTGAACCTAGTTCAACTGAGGCTATTGCATCTGAGAAGAAAGAAGATGAA

GCCGTAACTCCAAAAGAGGAAAAAGTGTCTGCTAAACCGGAAGAAAAAGCTCCAAGGATAGAATCACAAGCTTC

AAATCAAGAAAAACCGCTCAAGGAAGATGCTAAAGCTGTAACAAATGAAGAAGTGAATCAAATGATTGAAGACA

GGAAAGTGGATTTTAATCAAAATTGGTACTTTAAACTCAATGCAAATTCTAAGGAAGCCATTAAACCTGATGCAG

ACGTATCTACGTGGAAAAAATTAGATTTACCGTATGACTGGAGTATCTTTAACGATTTCGATCATGAATCTCCTGC

ACAAAATGAAGGTGGACAGCTCAACGGTGGGGAAGCTTGGTATCGCAAGACTTTCAAACTAGATGAAAAAGACCT

CAAGAAAAATGTTCGCCTTACTTTTGATGGCGTCTACATGGATTCTCAAGTTTATGTCAATGGTCAGTTAGTGGGG

CATTATCCAAATGGTTATAACCAGTTCTCATATGATATCACCAAATACCTTCAAAAAGATGGTCGTGAGAATGTGA

TTGCTGTCCATGCAGTCAACAAACAGCCAAGTAGCCGTTGGTATTCAGGAAGTGGTATCTATCGTGATGTGACTTT

ACAAGTGACAGATAAGGTGCATGTTGAGAAAAATGGGACAACTATTTTAACACCAAAACTTGAAGAACAACAACA

TGGCAAGGTTGAAACTCATGTGACCAGCAAAATCGTCAATACGGACGACAAAGACCATGAACTTGTAGCCGAATA

TCAAATCGTTGAACGAGGTGGTCATGCTGTAACAGGCTTAGTTCGTACAGCGAGTCGTACCTTAAAAGCACATGA

ATCAACAAGCCTAGATGCGATTTTAGAAGTTGAAAGACCAAAACTCTGGACTGTTTTAAATGACAAACCTGCCTTG

TACGAATTGATTACGCGTGTTTACCGTGACGGTCAATTGGTTGATGCTAAGAAGGATTTGTTTGGTTACCGTTACT

ATCACTGGACTCCAAATGAAGGTTTCTCTTTGAATGGTGAACGTATTAAATTCCATGGAGTATCCTTGCACCACGA

CCATGGGGCGCTTGGAGCAGAAGAAAACTATAAAGCAGAATATCGCCGTCTCAAACAAATGAAGGAGATGGGAG

TTAACTCCATCCGTACAACCCACAACCCTGCTAGTGAGCAAACCTTGCAAATCGCAGCAGAACTAGGTTTACTCGT

TCAGGAAGAGGCCTTTGATACGTGGTATGGTGGCAAGAAACCTTATGACTATGGACGTTTCTTTGAAAAAGATGC

CACTCACCCAGAAGCTCGAAAAGGTGAAAAATGGTCTGATTTTGACCTACGTACCATGGTCGAAAGAGGCAAAAA

CAACCCTGCTATCTTCATGTGGTCAATTGGTAATGAAATAGGTGAAGCTAATGGTGATGCCCACTCTTTAGCAACT

GTTAAACGTTTGGTTAAGGTTATCAAGGATGTTGATAAGACTCGCTATGTTACCATGGGAGCAGATAAATTCCGTT

TCGGTAATGGTAGCGGAGGGCATGAGAAAATTGCTGATGAACTCGATGCTGTTGGATTTAACTATTCTGAAGATA

ATTACAAAGCCCTTAGAGCTAAGCATCCAAAATGGTTGATTTATGGATCAGAAACATCTTCAGCTACCCGTACACG

TGGAAGTTACTATCGCCCTGAACGTGAATTGAAACATAGCAATGGACCTGAGCGTAATTATGAACAGTCAGATTA

TGGAAATGATCGTGTGGGTTGGGGGAAAACAGCAACCGCTTCATGGACTTTTGACCGTGACAACGCTGGCTATGC

TGGACAGTTTATCTGGACAGGTACGGACTATATTGGTGAACCTACACCATGGCACAACCAAAATCAAACTCCTGTT

AAGAGCTCTTACTTTGGTATCGTAGATACAGCCGGCATTCCAAAACATGACTTCTATCTCTACCAAAGCCAATGGG

TTTCTGTTAAGAAGAAACCGATGGTACACCTTCTTCCTCACTGGAACTGGGAAAACAAAGAATTAGCATCCAAAG

TAGCTGACTCAGAAGGTAAGATTCCAGTTCGTGCTTATTCGAATGCTTCTAGTGTAGAATTGTTCTTGAATGGAAA

ATCTCTTGGTCTTAAGACTTTCAATAAAAAACAAACCAGCGATGGGCGGACTTACCAAGAAGGTGCAAATGCTAA

TGAACTTTATCTTGAATGGAAAGTTGCCTATCAACCAGGTACCTTGGAAGCAATTGCTCGTGATGAATCTGGCAAG

GAAATTGCTCGAGATAAGATTACGACTGCTGGTAAGCCAGCGGCAGTTCGTCTTATTAAGGAAGACCATGCGATT

GCAGCAGATGGAAAAGACTTGACTTACATCTACTATGAAATTGTTGACAGCCAGGGGAATGTGGTTCCAACTGCT

AATAATCTGGTTCGCTTCCAATTGCATGGCCAAGGTCAACTGGTCGGTGTAGATAACGGAGAACAAGCCAGCCGT

GAACGCTATAAGGCGCAAGCAGATGGTTCTTGGATTCGTAAAGCATTTAATGGTAAAGGTGTTGCCATTGTCAAAT

CAACTGAACAAGCAGGGAAATTCACCCTGACTGCCCACTCTGATCTCTTGAAATCGAACCAAGTCACTGTCTTTAC

TGGTAAGAAAGAAGGACAAGAGAAGACTGTTTTGGGGACAGAAGTGCCAAAAGTACAGACCATTATTGGAGAGG

CACCTGAAATGCCTACCACTGTTCCGTTTGTATACAGTGATGGTAGCCGTGCAGAACGTCCTGTAACCTGGTCTTC

AGTAGATGTGAGCAAGCCTGGTATTGTAACGGTGAAAGGTATGGCTGACGGACGAGAAGTAGAAGCTCGTGTAGA

AGTGATTGCTCTTAAATCAGAGCTACCAGTTGTGAAACGTATTGCTCCAAATACTGACTTGAATTCTGTAGACAAA

TCTGTTTCCTATGTTTTGATTGATGGAAGTGTTGAAGAGTATGAAGTGGACAAGTGGGAGATTGCCGAAGAAGATA

AAGCTAAGTTAGCAATTCCAGGTTCTCGTATTCAAGCGACCGGTTATTTAGAAGGTCAACCAATTCATGCAACCCT

TGTGGTAGAAGAAGGCAATCCTGCGGCACCTGCAGTACCAACTGTAACGGTTGGTGGTGAGGCAGTAACAGGTCT

TACTAGTCAAAAACCAATGCAATACCGCACTCTTGCTTATGGAGCTAAGTTGCCAGAAGTCACAGCAAGTGCTAA

AAATGCAGCTGTTACAGTTCTTCAAGCAAGCGCAGCAAACGGCATGCGTGCGAGCATCTTTATTCAGCCTAAAGA

TGGTGGCCCTCTTCAAACCTATGCAATTCAATTCCTTGAAGAAGCGCCAAAAATTGCTCACTTGAGCTTGCAAGTG

GAAAAAGCTGACAGTCTCAAAGAAGACCAAACTGTCAAATTGTCGGTTCGAGCTCACTATCAAGATGGAACGCAA

GCTGTATTACCAGCTGATAAAGTAACCTTCTCTACAAGTGGTGAAGGGGAAGTCGCAATTCGTAAAGGAATGCTT

GAGTTGCATAAGCCAGGAGCAGTCACTCTGAACGCTGAATATGAGGGAGCTAAAGACCAAGTTGAACTCACTATC

CAAGCCAATACTGAGAAGAAGATTGCGCAATCCATCCGTCCTGTAAATGTAGTGACAGATTTGCATCAGGAACCA

AGTCTTCCAGCAACAGTAACAGTTGAGTATGACAAAGGTTTCCCTAAAACTCATAAAGTCACTTGGCAAGCTATTC

CGAAAGAAAAACTAGACTCCTATCAAACATTTGAAGTACTAGGTAAAGTTGAAGGAATTGACCTTGAAGCGCGTG

CAAAAGTCTCTGTAGAAGGTATCGTTTCAGTTGAAGAAGTCAGTGTGACAACTCCAATCGCAGAAGCACCACAAT

TACCAGAAAGTGTTCGGACATATGATTCAAATGGTCACGTTTCATCAGCTAAGGTTGCATGGGATGCGATTCGTCC

AGAGCAATACGCTAAGGAAGGTGTCTTTACAGTTAATGGTCGCTTAGAAGGTACGCAATTAACAACTAAACTTCA

TGTTCGCGTATCTGCTCAAACTGAGCAAGGTGCAAACATTTCTGACCAATGGACCGGTTCAGAATTGCCACTTGCC

TTTGCTTCAGACTCAAATCCAAGCGACCCAGTTTCAAATGTTAATGACAAGCTCATTTCCTACAATAACCAACCAG

CCAATCGTTGGACAAACTGGAATCGTACTAATCCAGAAGCTTCAGTCGGTGTTCTGTTTGGAGATTCAGGTATCTT

GAGCAAACGCTCCGTTGATAATCTAAGTGTCGGATTCCATGAAGACCATGGAGTTGGTGTACCGAAGTCTTATGTG

ATTGAGTATTATGTTGGTAAGACTGTCCCAACAGCTCCTAAAAACCCTAGTTTTGTTGGTAATGAGGACCATGTCT

TTAATGATTCTGCCAACTGGAAACCAGTTACTAATCTAAAAGCCCCTGCTCAACTCAAGGCTGGAGAAATGAACC

ACTTTAGCTTTGATAAAGTTGAAACCTATGCTGTTCGTATTCGCATGGTTAAAGCAGATAACAAGCGTGGAACGTC

TATCACAGAGGTACAAATCTTTGCGAAACAAGTTGCGGCAGCCAAGCAAGGACAAACAAGAATCCAAGTTGACGG

CAAAGACTTAGCAAACTTCAACCCTGATTTGACAGACTACTACCTTGAGTCTGTAGATGGAAAAGTTCCGGCAGTC

ACAGCAAGTGTTAGCAACAATGGTCTCGCTACCGTCGTTCCAAGCGTTCGTGAAGGTGAGCCAGTTCGTGTCATCG

CGAAAGCTGAAAATGGCGACATCTTAGGAGAATACCGTCTGCACTTCACTAAGGATAAGAGCTTACTTTCTCATA

AACCAGTTGCTGCGGTTAAACAAGCTCGCTTGCTACAAGTAGGTCAAGCACTTGAATTGCCGACTAAGGTTCCAGT

TTACTTCACAGGTAAAGACGGCTACGAAACAAAAGACCTGACAGTTGAATGGGAAGAAGTTCCAGCGGAAAATCT

GACAAAAGCAGGTCAATTTACTGTTCGAGGCCGTGTCCTTGGTAGTAACCTTGTTGCTGAGATCACTGTACGAGTG

ACAGACAAACTTGGTGAGACTCTTTCAGATAACCCTAACTATGATGAAAACAGTAACCAGGCCTTTGCTTCAGCA

ACCAATGATATTGACAAAAACTCTCATGACCGCGTTGACTATCTCAATGACGGAGATCATTCAGAAAATCGTCGTT

GGACAAACTGGTCACCAACACCATCTTCTAATCCAGAAGTATCAGCGGGTGTGATTTTCCGTGAAAATGGTAAGA

TTGTAGAACGGACTGTTACACAAGGAAAAGTTCAGTTCTTTGCAGATAGTGGTACGGATGCACCATCTAAACTCGT

TTTAGAACGCTATGTCGGTCCAGAGTTTGAAGTGCCAACCTACTATTCAAACTACCAAGCCTACGACGCAGACCAT

CCATTCAACAATCCAGAAAATTGGGAAGCTGTTCCTTATCGTGCGGATAAAGACATTGCAGCTGGTGATGAAATC

AACGTAACATTTAAAGCTATCAAAGCCAAAGCTATGAGATGGCGTATGGAGCGTAAAGCAGATAAGAGCGGTGTT

GCGATGATTGAGATGACCTTCCTTGCACCAAGTGAATTGCCTCAAGAAAGCACTCAATCAAAGATTCTTGTAGATG

GAAAAGAACTTGCTGATTTCGCTGAAAATCGTCAAGACTATCAAATTACCTATAAAGGTCAACGGCCAAAAGTCT

CAGTTGAAGAAAACAATCAAGTAGCTTCAACTGTGGTAGATAGTGGAGAAGATAGCTTTCCAGTACTTGTTCGCCT

CGTTTCAGAAAGTGGAAAACAAGTCAAGGAATACCGTATCCACTTGACTAAGGAA

AAACCAGTTTCTGAGAAGACAGTTGCTGCTGTACAAGAAGATCTTCCAAAAATCGAATTTGTTGAAAAAGATTTG

GCATACAAGACAGTTGAGAAAAAAGATTCAACACTGTATCTAGGTGAAACTCGTGTAGAACAAGAAGGAAAAGTT

GGAAAAGAACGTATCTTTACAGCGATTAATCCTGATGGAAGTAAGGAAGAAAAACTCCGTGAAGTGGTAGAAGTT

CCGACAGACCGCATCGTCTTGGTTGGAACCAAACCAGTAGCTCAAGAAGCTAAAAAACCACAAGTGTCAGAAAAA

GCAGATACAAAACCAATTGATTCAAGTGAAGCTAGTCAAACTAATAAAGCCCAGTTACCAAGTACAGGTAGTGCG

GCAAGCCAAGCAGCAGTAGCAGCAGGTTTAACTCTTCTAGGTTTGAGTGCAGGATTAGTAGTTACTAAAGGTAAA

AAAGAAGACTAG

4101.5

ATGGATGCAATCTTTGACCTAATCGGAAAGGTTTTCAATCCCATCTTAGAAATGGGTGGACCTGTCATCATGTTAA

TCATTTTGACAGTATTGGCTTTACTTTTTGGAGTGAAATTCTCCAAAGCGCTTGAAGGTGGTATCAAACTTGCCAT

CGCTCTTACAGGTATCGGTGCTATCATCGGTATGCTAAACACTGCTTTCTCAGCATCACTAGCAAAATTCGTTGAA

AACACTGGTATCCAATTGAGTATTACCGACGTTGGTTGGGCACCACTTGCTACAATCACTTGGGGTTCTGCTTGGA

CACTATACTTCTTGCTCATCATGTTGATTGTCAACATAGTGATGCTAGCTATGAAGAAAACAGATACACTTGATGT

CGATATCTTTGATATCTGGCACTTGTCTATCACAGGTCTCTTGATTAAATGGTATGCTGATAACAATGGTGTGAGT

CAAGGGGTTTCACTCTTTATTGCTACAGCAGCTATCGTCCTTGTCGGTGTGTTGAAAATTATCAACTCTGACTTGAT

GAAACCTACATTTGATGACCTTCTTAACGCCCCAAGTTCATCACCAATGACATCAACTCACATGAACTACATGATG

AACCCAGTTATCATGGTTTTGGATAAGATTTTTGAAAAATTCTTCCCAGGCCTTGATAAATATGACTTTGATGCTG

CTAAATTGAACAAGAAAATCGGTTTCTGGGGATCTAAATTCTTCATCGGTTTCATCCTTGGTATCGTTATCGGTATT

ATGGGAACTCCACATCCAATTGCAGGTGTTGCAGATGCAGATAAATGGCGTCTTGTTATCAAAGGATGGTTGTCTC

TTGGTTTGACTGCCGGTGTATCTTTGGAACTCTTCTCACTTATCGGTTCATGGTTCATCGCAGCCGTAGAACCACTA

TCACAAGGTATTACAAACGTTGCTACTAAACGTCTTCAAGGACGTAAATTCAATATCGGTCTTGACTGGCCATTCA

TCGCTGGTCGTGCTGAAATCTGGGCTTGTGCCAACGTACTTGCACCAATCATGTTGATTGAAGCAGTGCTTCTTTC

AAAAGTTGGAAATGGTATCTTGCCACTTGCAGGTATCATCGCTATGGGTGTTACTCCAGCTCTCTTGGTTGTAACT

CGTGGTAAATTGCTCCGTATGATTATCTTCGGAACACTCTTGTTGCCACTCTTCCTTCTTTCAGGTACACTTATTGC

ACCATTTGCAACAGAACTTGCTAAAGGTGTAGGTGCCTTCCCAGAAGGTGTGAGCCAAACTCAATTGATTACTCAC

TCTACTCTTGAAGGACCAATCGAAAAACTTCTTGGTTGGACAATTGGTAACACTACAACTGGTGATATCAAAGCAA

TCCTTGGTGCAGTAGTCTTCCTTGTATTCTATATCGGTATCTTTGCTTGGTACAGAAAACAAATGATCAAACGTAA

CGAAGAGTACGCAGCAAAAGCAAAATAA

4102.1

ATGAAGATTATGAAAAAAAAATATTGGACTTTAGCGATATTATTCTTTTGTTTGTTCAATAATTCTGTTACTGCTCA

AGAAATACCTAAAAATCTTGATGGCAATATAACTCACACTCAGACTAGCGAAAGTTTTTCTGAATCTGATGAAAA

ACAGGTTGACTATTCTAATAAAAATCAAGAAGAAGTAGACCAAAATAAATTTCGTATTCAAATCGATAAGACAGA

ATTATTTGTAACAACAGATAAACATTTAGAAAAAAACTGTTGTAAAAAGGAACTTGAACCACAAATAAATAACGA

TATTGTTAACTCTGAAAGTAATAATTTACTAGGCGAAGATAATTTAGATAATAAAATTAAGGAAAATGTTTCTCAT

CTAGATAATAGAGGAGGAAATATAGAGCATGACAAAGATAACTTAGAATCGTCGATTGTAAGAAAATATGAATGG

GATATAGATAAAGTTACTGGTGGAGGCGAAAGTTATAAATTATATTCTAAAAGTAATTCTAAAGTTTCAATTGCTA

TTTTAGATTCAGGAGTCGATTTACAAAATACTGGATTACTGAAAAATCTTTCAAATCACTCAAAAAACTATGTCCC

CAATAAAGGATATTTAGGAAAAGAGGAGGGAGAGGAAGGAATAATATCAGATATTCAAGATAGATTAGGTCATG

GTACGGCTGTTGTAGCTCAAATTGTAGGGGATGACAATATTAATGGAGTAAATCCTCACGTTAATATTAACGTCTA

TAGAATATTTGGTAAGTCGTCAGCTAGTCCAGATTGGATTGTAAAAGCAATTTTTGATGCTGTAGATGATGGCAAT

GATATTATCAATCTTAGTACTGGACAATATTTAATGATTGATGGAGAATATGAGGACGGAACAAATGATTTTGAAA

CATTTTTGAAGTATAAAAAGGCTATTGATACGCGAATCAAAAAGGAGTAATTATAGTAGCTGCATTAGGGAATG

ACTCCCTAAATGTATCAAATCAGTCAGATTTATTGAAACTTATTAGTTCACGCAAAAAAGTAAGAAAACCAGGATT

AGTAGTTGATGTTCCAAGTTATTTCTCATCTACAATTTCGGTCGGAGGCATAGATCGCTTAG

GTAATTTATCAGATTTTAGCAATAAAGGGGATTCTGATGCAATATATGCGCCTGCAGGCTCAACATTATCTCTTTC

AGAATTAGGACTTAATAACTTTATTAATGCAGAAAAATATAAAGAAGATTGGATTTTTTCGGCAACACTAGGAGG

ATATACGTATCTTTATGGAAACTCATTTGCTGCTCCTAAAGTTTCTGGTGCGATTGCAATGATTATTGATAAATACA

AATTAAAAGATCAGCCCTATAATTATATGTTTGTAAAAAAATTCTGGAAGAAACATTACCAGTAA

4106.1

ATGAAGAAAACATGGAAAGTGTTTTTAACGCTTTGTAACAGCTCTTGTAGCTGTTGTGCTTGTGGCCTGTGGTCAAG

GAACTGCTTCTAAAGACAACAAAGAGGCAGAACTTAAGAAGGTTGACTTTATCCTAGACTGGACACCAAATACCA

ACCACACAGGGCTTTATGTTGCCAAGGAAAAAGGTTATTTCAAAGAAGCTGGAGTGGATGTTGATTTGAAATTGC

CACCAGAAGAAAGTTCTTCTGACTTGGTTATCAACGGAAAGGCACCATTTGCAGTGTATTTCCAAGACTACATGGC

TAAGAAATTGGAAAAAGGAGCAGGAATCACTGCCGTTGCAGCTATTGTTGAACACAATACATCAGGAATCATCTC

TCGTAAATCTGATAATGTAAGCAGTCCAAAAGACTTGGTTGGTAAGAAATATGGGACATGGAATGACCCAACTGA

ACTTGCTATGTTGAAAACCTTGGTAGAATCTCAAGGTGGAGACTTTGAGAAGGTTGAAAAAGTACCAAATAACGA

CTCAAACTCAATCACACCGATTGCCAATGGCGTCTTTGATACTGCTTGGATTTACTACGGTTGGGATGGTATCCTT

GCTAAATCTCAAGGTGTAGATGCTAACTTCATGTACTTGAAAGACTATGTCAAGGAGTTTGACTACTATTCACCAG

TTATCATCGCAAACAACGACTATCTGAAAGATAACAAAGAAGAAGCTCGCAAAGTCATCCAAGCCATCAAAAAAG

GCTACCAATATGCCATGGAACATCCAGAAGAAGCTGCAGATATTCTCATCAAGAATGCACCTGAACTCAAGGAAA

AACGTGACTTTGTCATCGAATCTCAAAAATACTTGTCAAAAGAATACGCAAGCGACAAGGAAAAATGGGGTCAAT

TTGACGCAGCTCGCTGGAATGCTTTCTACAAATGGGATAAAGAAAATGGTATCCTTAAAGAAGACTTGACAGACA

AAGGCTTCACCAACGAATTTGTGAAATAA

4106.4

ATGATAAAAAATCCTAAATTATTAACCAAGTCTTTTTTAAGAAGTTTTGCAATTCTAGGTGGTGTTGGTCTAGTCA

TTCATATAGCTATTTATTTGACCTTTCCTTTTTATTATATTCAACTGGAGGGGGAAAAGTTTAATGAGAGCGCAAG

AGTGTTTACGGAGTATTTAAAGACTAAGACATCTGATGAAATTCCAAGCTTACTCCAGTCTTATTCAAAGTCCTTG

ACCATATCTGCTCACCTTAAAAGAGATATTGTAGATAAGCGGCTCCCTCTTGTGCATGACTTGGATATTAAAGATG

GAAAGCTATCAAATTATATCGTGATGTTAGATATGTCTGTTAGTACAGCAGATGGTAAACAGGTAACCGTGCAATT

TGTTCACGGGGTGGATGTCTACAAAGAAGCAAAGAATATTTTGCTTTTGTATCTCCCATATACATTTTTGGTTACA

ATTGCTTTTTCCTTTGTTTTTTCTTATTTTTATACTAAACGCTTGCTCAATCCTCTTTTTTACATTTCAGAAGTGACT

AGTAAAATGCAAGATTTGGATGACAATATTCGTTTTGATGAAAGTAGGAAAGATGAAGTTGGTGAAGTTGGAAAA

CAGATTAATGGTATGTATGAGCACTTGTTGAAGGTTATTTATGAGTTGGAAAGTCGTAATGAGCAAATGTAAAAT

TGCAAAATCAAAAGGTTTCCTTTGTCCGCGGAGCATCACATGAGTTGAAAACCCCTTTAGCCAGTCTTAGAATTAT

CCTAGAGAATATGCAGCATAATATTGGAGATTACAAAGATCATCCAAAATATATTGCAAAGAGTATAAATAAGAT

TGACCAGATGAGCCACTTATTAGAAGAAGTACTGGAGTCTTCTAAATTCCAAGAGTGGACAGAGTGTCGTGAGAC

CTTGACTGTTAAGCCAGTTTTAGTAGATATTTTATCACGTTATCAAGAATTAGCTCATTCAATAGGTGTTACAATTG

AAAATCAATTGACAGATGCTACCAGGGTCGTCATGAGTCTTAGGGCATTGGATAAGGTTTTGACAAACCTGATTA

GTAATGCAATTAAATATTCAGATAAAAATGGGCGTGTAATCATATCCGAGCAAGATGGCTATCTCTCTATCAAAA

ATACATGTGCGCCTCTAAGTGACCAAGAACTAGAACATTTATTTGATATATTCATCATTCTCAAATCGTGACAGA

TAAGGATGAAAGTTCCGGTTTGGGTCTTTACATTGTGAATAATATTTTAGAAAGCTATCAAATGGATTATAGTTTT

CTCCCTTATGAACACGGTATGGAATTTAAGATTAGCTTGTAG

4106.6

ATGTATTTAGGAGATTTGATGGAGAAAGCCGAGTGTGGTCAATTTTCAATACTTTCCTTTCTATTACAAGAGTCTC

AGACGACCGTCAAGGCTGTAATGGAAGAAACAGGATTTTCAAAAGCAACCCTAACCAAATATGTCACCCTGCTCA

ATGACAAGGCTTTGGATAGTGGCTTAGAGCTGGCTATTCACTCAGAAGATGAAAATCTGCGTCTGTCTATCGGTGC

AGCTACCAAGGGGAGAGATATTCGGAGCTTGTTTTTGGAGAGTGCTGTTAAATACCAGATTTTGGTTTATCTTCTC

TACCACCAACAGTTTTTAGCCCATCAGCTGGCTCAAGAATTGGTGATTAGCGAGGCTACGCTTGGTCGTCACTTGG

CTGGTTTAAATCAGATTTTGTCAGAATTTGATTTATCCATCCAAAATGGCCGTTGGCGAGGTCCAGAGCATCAGAT

TCACTATTTCTATTTCTCTCTTTTTCCGAAAGGTCTGGTCGAGTCAGGAATGGGAAGGTCACATGCAGAAACCAGAG

AGAAAACAGGAGATTGCCAATTTAGAGGAAATCTGCGGTGCAAGTTTGTCTGCGGGGCAGAAATTGGACTTGGTT

CTCTGGGCTCACATCAGTCAACAACGTCTTCGGGTCAATGCTTGTCAGTTTCAAGTCATAGAAGAGAAAATGCGA

GGGTATTTTGACAATATCTTTTATCTTCGTTTGCTGAGAAAGGTTCCGTCCTTTTTTGCTGGGCAACATATTCCACT

AGGAGTTGAGGATGGTGAGATGATGATATTCTTCTCTTTTCTCCTATCTCATCGCATTCTTCCTCTTCATACTATGG

AGTATATTCTTGGTTTTGGAGGGCAGTTGGCAGATTTACTGACGCAATTGATTCAAGAAATGAAGAAGGAGGAAC

TATTGGGGGATTATACAGAGGACCATGTCACCTATGAACTCAGTCAGCTTTGTGCTCAAGTCTATCTCTATAAGGG

CTATATTTTACAGGATCGCTACAAGTACCAGTTAGAGAATCGTCATCCATATTTACTGATGGAACATGATTTTAAA

GAGACAGCAGAGGAGATTTTTCATGCTCTACCTGCTTTTCAACAGGGGACAGATTTAGATAAGAAGATTCTCTGGG

AATGGCTCCAGTTAATCGAATATATGGCTGAAAACGGTGGCCAGCATATGCGGATTGGTCTGGATTTGACATCTGG

TTTTCTTGTCTTTTCAAGGATGGCAGCCATTTTGAAACGGTATTTGGAATACAATCGTTTTATTACCATTGAAGCTT

ATGACCCTAGTCGGCATTATGATTTGCTGGTTACCAATAACCCGATTCATAAGAAGGAACAGACACCAGTCTATTA

TTTAAAAAATGACTTGGATATGGAGGATTTGGTAGCGATTCGCCAGTTATTATTCACTTAA

4106.7

ATGGAATTTTCAAAGAAAACACGTGAATTGTCAATTAAAAAAATGCAGGAACGTACCCTGGACCTCTTGATTATC

GGTGGAGGAATCACAGGAGCTGGTGTAGCCTTGCAGGCGGCAGCTAGCGGTCTTGAGACTGGTTTGATTGAAATG

CAAGACTTTGCAGAAGGAACATCTAGTCGTTCAACAAAATTGGTTCACGGAGGACTTCGTTACCTCAAACAATTTG

ACGTAGAAGTGGTCTCAGATACGGTTTCTGAACGTGCAGTGGTTCAACAAATCGCTCCACACATTCCAAAATCAG

ATCCAATGCTCTTACCAGTTTACGATGAAGATGGAGCAACCTTTAGCCTCTTCCGTCTTAAAGTAGCCATGGACTT

GTACGACCTCTTGGCAGGTGTTAGCAACACACCAGCTGCGAACAAGGTTTTGAGCAAGGATCAAGTCTTGGAACG

CCAGCCAAACTTGAAGAAGGAAGGCTTGGTAGGAGGTGGAGTGTATCTTGACTTCCGTAACAACGATGCGCGTCT

CGTGATTGAAAACATCAAACGTGCCAACCAAGACGGTGCCCTCATTGCCAACCACGTGAAGGCAGAAGGCTTCCT

CTTTGACGAAAGTGGCAAGATTACAGGTGTTGTAGCTCGTGATCTCTTGACAGACCAAGTGTTTGAAATCAAGGCC

CGTCTGGTTATTAATACAACAGGTCCTTGGAGTGATAAAGTACGTAATTTGTCTAATAAGGGAACGCAATTCTCAC

AAATGCGCCCAACTAAGGGAGTTCACTTGGTAGTAGATTCAAGCAAAATCAAGGTTTCACAGCCAGTTTACTTCG

ACACAGGTTTGGGTGACGGTCGTATGGTCTTTGTTCTCCCACGTGAAAACAAGACTTACTTTGGTACAACTGATAC

AGACTACACAGGTGATTTGGAGCATCCAAAAGTAACTCAAGAAGATGTAGATTATCTACTTGGCATTGTCAACAA

CCGCTTCCCAGAATCCAACATCACCATTGATGATATCGAAAGCAGCTGGGCAGGTCTTCG

TCCATTGATTGCAGGGAACAGTGCCTCTGACTATAATGGTGGAAATAACGGTACCATCAGTGATGAAAGCTTTGA

CAACTTGATTGCGACTGTTGAATCTTATCTCTCCAAAGAAAAAACACGTGAAGATGTTGAGTCTGCTGTCAGCAAG

CTTGAAAGTAGCACATCTGAGAAACATTTGGATCCATCTGCAGTTTCTCGTGGGTCTAGCTTGGACCGTGATGACA

ATGGTCTCTTGACTCTTGCTGGTGGTAAAATCACAGACTACCGTAAGATGGCTGAAGGAGCTATGGAGCGCGTGG

TTGACATCCTCAAAGCAGAATTTGACCGTAGCTTTAAATTGATCAATTCTAAAACTTACCCTGTTTCAGGTGGAGA

ATTGAACCCAGCAAATGTGGATTCAGAAATCGAAGCCTTTGCGCAACTTGGAGTATCACGTGGTTTGGATAGCAA

GGAAGCTCACTATCTGGCAAATCTTTACGGTTCAAATGCACCGAAAGTCTTTGCACTTGCTCACAGCTTGGAACAA

GCGCCAGGACTCAGCTTGGCAGATACTTTGTCCCTTCACTATGCAATGCGCAATGAGTTGACTCTTAGCCCAGTTG

ACTTCCTTCTTCGTCGTACCAATCACATGCTCTTTATGCGTGATAGCTTGGATAGTATCGTTGAGCCAATTTTGGAT

GAAATGGGACGATTCTATGACTGGACAGAAGAAGAAAAGCAACTTACCGTGCTGATGTCGAAGCAGCTCTCGCT

AACAACGATTTAGCAGAATTAAAAAATTAA

4106.8

ATGATGAATGAATTATTTGGAGAATTTCTAGGGACTTTAATCCTGATTCTTCTAGGAAATGGTGTTGTTGCAGGTG

TGGTTCTTCCTAAAACCAAGAGCAATAGCTCAGGTTGGATTGTGATTACTATGGGTTGGGGGATTGCAGTTGCGGT

TGCAGTCTTTGTATCTGGCAAGCTCAGTCCAGCTTATTTAAACCCAGCTGTGACCATCGGTGTGGCCTTAAAAGGT

GGTTTGCCTTGGGCTTCCGTTTTGCCTTATATCTTAGCCCAGTTCGCAGGGGCCATGCTGGGTCAGATTTTGGTTTG

GTTGCAATTCAAACCTCACTATGAGGCAGAAGAAAATGCAGGCAATATCCTGGCAACCTTCAGTACTGGACCAGC

CATCAAGGATACTGTATCAAACTTGATTAGCGAAATCCTTGGAACTTTTGTTTTGGTGTTGACAATCTTTGCTTTGG

GTCTTTACGACTTTCAGGCAGGTATCGGAACCTTTGCAGTGGGAACTTTGATTGTCGGTATCGGTCTATCACTAGG

TGGGACAACAGGTTATGCCTTGAACCCAGCTCGTGACCTTGGACCTCGTATCATGCACAGCATCTTGCCAATTCCA

AACAAGGGAGACGGAGACTGGTCTTACGCTTGGATTCCTGTTGTAGGCCCTGTTATCGGAGCAGCCTTGGCAGTG

CTTGTATTCTCACTTTTCTAG

4106.10

ATGAAAAGGACCTGGAGGAACTCATTCGTGACAAATCTTAATACACCTTTTATGATTGGCAATATTGAGATTCCCA

ATCGTACCGTTTTAGCGCCTATGGCTGGCGTGACCAACTCAGCCTTTCGTACTATCGCAAAGGAGCTCGGAGCTGG

ACTCGTTGTAATGGAAATGGTCTCTGACAAGGGAATCCAATACAACAACGAAAAAACCCTGCACATGCTTCATAT

CGATGAGGGCGAAAACCCTGTCTCTATCCAACTTTTTGGTAGCGATGAAGACAGCCTAGCACGCGCAGCAGAATT

CATCCAAGAAAACACCAAGACCGATATCGTCGATATCAACATGGGCTGCCCTGTCAACAAAATCGTGAAGAACGA

AGCTGGTGCTATGTGGCTCAAGGATCCAGACAAGATTTACTCCATCATCAACAAGGTCCAGTCTGTCCTTGATATC

CCACTTACTGTCAAAATGCGTACCGGCTGGGCGGACCCATCTCTTGCAGTAGAAAATGCTCTCGCTGCTGAAGCTG

CAGGTGTTTCTGCCCTCGCCATGCATGGCCGTACCCGTGAACAAATGTATACTGGCCACGCAGACCTTGAGACCCT

TTACAAGGTTGCCCAAGCTCTAACCAAGATTCCATTCATCGCCAACGGTGATATCCGTACTGTCCAAGAAGCCAA

GCAACGCATCGAAGAAGTTGGTGCTGACGCAGTCATGATTGGCCGAGCTGCCATGGGAAATCCTTACCTCTTCAA

CCAAATCAACCATTACTTTGAAACAGGAGAAATCCTACCTGATTTGACCTTTGAAGACAAGATGAAGATCGCCTA

CGAACACTTGAAACGATTGATTAACCTCAAAGGAGAAAACGTCGCAGTTCGTGAATTCCGCGGTCTCGCTCCTCA

CTATCTCCGTGGAACATCTGGCGCTGCCAAACTCCGTGGAGCCATTTCGCAAGCCAGCACCCTGGCAGAGATTGA

AACCCTCTTGCAATTGGAGAAGGCTTAA

4107.1

ATGACAAAGAAGAAAATTGAGCGTATTTCTGTAATACACCGAGAAAAGATTTTATGGCTCAAGTGGTATTTCATGC

GAGATAAAGAACAACCTAAGTATAGTGTCCTTGAGCGTAAAATGTTTGATGCTGCTAAAAATCAAGATATGCTAG

CTTATCAAAAATACGCAACTATCAAGCAGATAACAGATATTAGGGTACAAACAAGTGAGGCTGACATTTTAGAGG

CTGTAAAAGAGGTTTATGTGTACAATCACATGAATGTTATCGGAGCTTGTCAGCGGATATTATTTATCAGTCAATC

ACCAGCTTATGATAAGTTAAATAAGTGGTTTAATATCTATTCTGATTTGTATTTTAGCGTTGTACCCTTGCCCAAAA

TGGGGGTATATCATGAGATGGTAGGTATCTAG

4107.2

ATGAAAAATTCCAACGAGGCTGAGATGAAATTACTTTATACTGATATTCGGACTTCTTTGACAGAAATTCTAACAA

GAGAGGCAGAAGAGCTAGTTGCAGCTGGCAAGCGGGTCTTCTACATTGCCCCCAACTCTCTTTCTTTTGAAAAGGA

ACGCGCCGTGCTGGAATACTTGTCCCAGCAGGCTTCTTTTTCGATTACCGTCACGCGCTTTGCTCAAATGGCTCGC

TATCTGGTCTTGAATGATTTACCAGCTAAAACTACTCTTGATGATATCGGTCTTGGGTTGGCCTTTTACAAATGCCT

TGCCGAACTCGATCCCAAGGACTTGCGTGTTTATGGCGCTATTAAGCAGGATCCTCAATTGATCCAGCAGTTAATT

GAGCTTTACCATGAGATGACCAAATCTCAGATGAGTTTTTTGGACTTGGAGAATTTAACAGATGAGGATAAGAGG

GCGGATTTACTCTTGATTTTTGAGAAAGTAACAGCCTATCTTAATCAAGGTCAGTTAGCCCAGGAAAGTCAGTTGT

CCCATTTGATTGAGGCTATTGAGAATGACAAGGTAAGTAGTGATTTTAATCAAATCGCCTTGGTCATTGACGGCTT

TACTCGTTTTTCTGCTGAGGAAGAGCGGGTTGTGGACTTACTTCACGGCAAAGGTGTTGAGATTGTTATCGGGGCT

TATGCTAGTAAGAAAGCCTATACCAGTCCTTTTAGCGAGGGCAATCTCTACCAAGCCAGCGTAAAATTTCTCCATC

ATCTGGCTTCTAAATACCAAACGCCTGCTCAGGACTGTTCTCAAACTCATGAGAAGATGGATAGTTTTGACAAGGC

CTCTCGTTTGTTGGAGTCTTCTTATGACTTTTCAGAACTCGCTTTGGATGTCGATGAGAAAGACCGTGAAAATTTA

CAAATCTGGTCTTGTTTGACGCAAAAGGAGGAGTTGGAGCTAGTAGCCCGTAGTATTCGTCAGAAATTACATGAG

AACTCAGACCTGAGCTACAAGCATTTTCGTATTCTCTTGGGGGATGTAGCTTCTTACCAGTTATCTCTCAAAACCA

TTTTTGACCAGTATCAGATTCCTTTTTATCTTGGTAGAAGCGAAGCCATGGCTCATCATCCCTTGACTCAGTTTGTC

GAGTCTATTTTAGCTTTAAAACGTTACCGTTTTCGTCAGGAGGATTTGATTAATCTTCTTAGAACTGATTTGTATAC

TGACCTCAGTCAGTCTGATATTGATGCTTTTGAGCAATATATCCGCTATCTTGGTATCAATGGCTTGCCAGCCTTTC

AGCAAACCTTCACCAAATCCCACCATGGAAAATTTAATCTTGAGCGTTTGAATGTCCTCCGCCTGAGAATTTTAGC

ACCTCTTGAAACCCTCTTTGCCAGCCGAAAACAAAAGGCTGAAAAACTCCTACAAAAATGGAGTGTCTTTCTAAA

AGAAGGAGCTGTGACCAAGCAGTTACAAGATTTGACAACCACTTTGGAAGCTGTAGAACAGGAAAGACAAGCCG

AAGTTTGGAAGGCTTTCTGCCATGTTTTAGAACAATTTGCGACTGTTTTTGCTGGTTCACAGGTTAGTCTGGAAGA

CTTCCTAGCCTTGCTCCATTCTGGAATGAGTTTGTCCCAATACCGTACCATTCCAGCAACAGTGGACACTGTTCTG

GTGCAGAGTTACGATTTGATTGCACCATTGACTGCTGACTTTGTCTATGCTATTGGACTAACTCAGGACAATTTAC

CAAAAATTTCTCAAAACACCAGTCTTCTGACAGATGAAGAAAGGCAAAACCTAAACCAAGCGACCGAAGAAGGC

GTTCAATTACTGATTGCCAGCAGTGAAAATCTCAAGAAAAATCGCTACACTATGCTTTCCTTGGTCAATTCTGCTC

GTAAGCAGTTGTTCTTGTCGGCTCCAAGCCTTTTTAACGAAAGTGAAAGTAAGGAATCTGCCTATCTTCAAGAGTT

GATCCATTTTGGATTTAGGCGGAGAGAGAAGAGGATGAATCACAAAGGACTGTCTAAGGAGGATATGGGGTCCTA

TCACAGTCTTTTGTCTAGTCTGGTTGCCTATCACCAGCAGGGTGAGATGAGCGATACTGAGCAAGATTTGACTTTT

GTCAAGGTTCTGTCGCGTGTCATAGGTAAAAAACTAGATCAGCAAGGTCTGGAAAATCCAGCTATCCCAACCAGT

CCAAGCAGCAAGACCTTAGCCAAGGACACCTTGCAAGCTCT

CTATCCTGCCAAACAGGAGTTTTACCTGTCTACGTCGGGTTTGACAGAGTTTTATCGCAATGAATACAGTTATTTC

CTACGCTACGTTTTAGGCTTGCAGGAGGAATTACGTTTGCATCCTGATGCCCGTAGTCACGGGAATTTCTTGCATC

GTATCTTTGAACGCGCCTTACAGTTGCCTAATGAAGATTCCTTTGACCAACGTCTAGAACAAGCTATTCAAGAAAC

CAGTCAAGAACGCGAATTTGAAGCTATTTATCAAGAAAGTTTGGAAGCCCAGTTTACCAAGGAAGTTTTGCTTGAT

GTTGCACGGACAACTGGACATATTCTCCGACACAATCCAGCCATCGAAACCATCAAAGAAGAAGCAAATTTTGGT

GGAAAAGACCAAGCCTTTATTCAATTAGACAATGGACGCAGTGTCTTTGTACGAGGCAAGGTGGACCGGATTGAC

CGTTTGAAAGCTAATGGAGCGATAGGAGTAGTAGACTACAAATCCAGTCTGACTCAGTTCCAGTTTCCTCATTTCT

TTAATGGGCTCAATTCTCAGTTACCAACCTATCTTGCTGCCCTAAAAAGAGAAGGGGAGCAGAACTTTTTCGGCGC

CATGTACTTGGAAATGGCTGAACCTGTCCAATCTCTGATGGCGGTAAAAAGTCTGGCAGGAGCAGTGGTAGAAGC

CAGCAAATCTATGAAATACCAAGGGCTCTTCTTGGAAAAAGAAAGCAGTTATTTAGGCGAATTTTATAACAAAAA

CAAGGCTAATCAACTGACAGATGAGGAATTTCAGCTCCTACTGGACTACAATGCCTATCTTTACAAGAAAGCTGCT

GAGAAGATTTTAGCAGGCCGGTTCGCCATCAATCCTTATACTGAAAATGGCAGAAGCATTGCCCCATACGTCCAG

CAACATCAGGCTATTACAGGCTTTGAAGCCAATTACCATCTGGGCCAAGCCCGTTTCCTAGAAAAGTTGGACCTAG

CTGATGGCAAGCGTCTGGTCGGAGAAAAACTCAAGCAAGCTTGGCTTGAAAAAATAA

GAGAGGAGTTGAATCGATGA

4107.3

ATGAAGCTTATTCCCTTTTTAAGTGAGGAGGAGATTCAAAAACTGCAAGAAGCAGAAGCAAATTCGAGCAAGGAA

CAGAAGAAAACTGCCGAGCAAATCGAAGCTATCTACACTTCTGCCCAGAATATCCTGGTCTCAGCATCGGCTGGT

TCTGGAAAGACCTTTGTCATGGCAGAGCGCATTCTGGACCAATTGGCGCGTGGTGTCGAAATTTCTCAACTCTTTA

TCTCAACCTTTACCGTCAAGGCTGCAACTGAACTTAAAGAACGTTTAGAGAAAAAAATCAGCAAGAAAATCCAAG

AAACAGATGATGTCGACCTCAAACAACACTTGGGTCGCCAGTTGGCAGACCTACCCAACGCTGCCATTGGAACCA

TGGATTCTTTCACACAAAAATTCCTTGGCAAACATGGTTATCTGCTTGATATTGCACCTAATTTCCGTATTTTACAA

AACCAAAGCGAGCAACTTATTCTCGAAAACGAAGTCTTTCATGAGGTCTTTGAAGCGCATTACCAAGGTAAACAG

AAAGAGACCTTTAGTCATTTGCTGAAAAACTTTGCTGGGCGTGGCAAGGACGAACGGGGTCTGCGCCAGCAGGTC

TATAAAATCTATGACTTCCTCCAATCCACCAGTAATCCTCAAAAGTGGCTGAGTGAATCTTTCCTCAAAGGATTTG

AGAAAGCTGATTTTACCAGTGAAAAAGAAAAACTGACCGAGCAAATCAAACAAGCCCTTTGGGATTTGGAAAGCT

TTTTCCGTTACCATCTGGATAACGATGCCAAGGAGTTTGCAAAGGCTGCCTATTTAGAAAATGTTCAGTTAATTCT

GGATGAAATTGGCTCCCTAAATCAGGAGTCCGATAGTCAGGCTTATCAGGCAGTGCTTGCGCGTGTTGTCGCCATC

TCTAAGGAGAAAAACGGTCGAGCTCTGACTAATGCCAGCCGTAAGGCTGATTTGAAGCCCCTGGCTGATGCCTAC

AACGAAGAGAGAAAGACCCAGTTTGCTAAACTAGGACAATTATCAGACCAGATAGCGAT

TCTCGACTATCAAGAACGTTATCATGGAGACACTTGGAAACTAGCTAAAACCTTCCAATCTTTCATGAGCGATTTT

GTAGAGGCTTATCGTCAGAGAAAACGACAGGAAAATGCCTTCGAATTCGCTGATATCAGCCATTACACCATTGAG

ATTTTAGAGAATTTCCCACAAGTTCGTGAGTCTTATCAGGAGCGCTTCCATGAAGTCATGGTCGATGAGTATCAGG

ATACCAACCATATTCAAGAACGGATGCTGGAATTGTTGTCTAATGGCCACAATCGCTTTATGGTGGGAGATATCAA

GCAATCCATCTATCGTTTCCGTCAGGCAGACCCGCAGATTTTCAATGAGAAATTCCAACGCTATGCGCAAAATCCC

CAAGAAGGCAGGCTCATTATCCTCAAGGAAAATTTCCGTAGTAGTTCAGAAGTGCTGTCAGCAACCAATGATGTC

TTTGAACGTCTCATGGACCAAGAGGTCGGCGAAATCAACTATGATAACAAGCACCAGCTTGTTTTTGCCAATACCA

AACTGACTCCCAATCCAGACAACAAGGCAGCATTTCTCCTCTACGACAAGGACGATACAGGTGAGGAAGAAGAGA

GTCAAACAGAAACGAAACTAACAGGCGAAATGCGCTTAGTTATCAAGGAGATTCTGAAACTTCATCAAGAAAAAG

GTGTTGCCTTTAAGGAAATTGCCCTTCTGACCTCCAGCCGCAGTCGTAATGACCAGATTCTCCTCGCCCTGTCTGA

GTACGGAATTCCTGTCAAAACTGACGGAGAGCAAAACAATTATCTCCAATCCCTAGAAGTGCAAGTCATGCTAGA

CACTCTTCGTGTCATTCACAATCCCCTGCAAGACTACGCCTTGGTTGCCCTTATGAAGTCTCCAATGTTTGGTTTTG

ATGAGGATGAGCTAGCACGTTTGTCCCTTCAGAAAGCAGAGGATAAAGTCCACGAAAATCTCTATGAGAAACTGG

TCAATGCACAAAAAATGGCAAGTAGTCAAAAAGGCTTGATTCACACAGCTCTAGCTG

AAAAACTAAAGCAATTCATGGATATCCTAGCTTCTTGGCGCTTGTATGCCAAAACCCACTCTCTCTATGACTTGAT

TTGGAAGATTTACAACGACCGTTTTTATTATGACTATGTTGGGGCTTTGCCGAATGGTCCTGCTAGGCAGGCCAAT

CTCTATGCCCTAGCACTGCGTGCTGATCAATTTGAAAAGAGCAATTTCAAAGGTTTGTCGCGTTTTATTCGTATGA

TTGACCAAGTCTTAGAAGCCCAGCACGATTTGGCAAGCGTGGCCGTCGCACCGCCAAAAGATGCAGTAGAGCTCA

TGACCATCCACAAGAGTAAAGGGCTGGAGTTTCCTTACGTCTTTATCCTCAATATGGATCAAGATTTCAACAAGCA

AGACTCTATGTCAGAAGTCATTCTCAGTCGTCAGAATGGTCTTGGTGTCAAATATATTGCCAAGATGGAGACAGGG

GCAGTAGAAGACCACTATCCTAAAACCATCAAACTCTCCATTCCTAGTCTGACCTATAGGCAGAACGAAGAGGAA

TTACAGCTAGCAAGCTATTCTGAGCAGATGCGTTTGCTGTATGTTGCTATGACGCGGGCTGAGAAAAAGCTCTATC

TTGTCGGCAAGGGTTCTCGTGAAAAGCTGGAATCCAAGGAATACCCAGCAGCCAAAAATGGGAAACTAAATAGCA

ATACTAGACTGCAAGCACGGAATTTCCAAGATTGGCTTTGGGCTATCAGTAAAGTGTTTACTAAGGACAAGCTCA

ACTTTAGTTATCGTTTTATTGGCGAAGATCAGTTGACCAGAGAAGCTATCGGAGAGTTGGAAACCAAGAGTCCTCT

CCAAGATAGCTCCCAAGCAGACAATCGTCAGTCAGATACCATCAAAGAAGCTCTGGAAATGCTGAAGGAGGTGGA

AGTTTATAATACTCTTCACCGCGCAGCTATTGAACTTCCTAGTGTTCAAACCCCAAGTCAAATCAAGAAATTCTAC

GAACCAGTTATGGATATGGAAGGTGTCGAGATTGCTGGTCAAGGTCAGTCAGTAGGCAAGAAAATCAGCTTCGAT

TTGCCAGATTTTTCAACCAAAGAAAAGGTAACTGGAGCTGAGATTGGTAGTGCTACTCACGAACTCATGCAGAGA

ATTGACCTCAGCCAGCAACTAACCCTTGCTAGCCTAACAGAAACACTCAAACAAGTTCAAACTAGCCAAGCTGTC

AGAGACAAGATCAATCTTGATAAAATTCTTGCTTTCTTTGACACAGTACTCGGTCAGGAAATTCTTGCTAATACCG

ACCATCTTTATCGCGAGCAACCTTTCTCCATGCTCAAACGAGACCAAAAGAGTCAGGAAGACTTTGTTGTCCGTGG

TATCCTTGATGGCTATCTGCTTTACGAAAACAAAATTGTTCTGTTCGACTACAAGACAGACCGCTATGATGAACCA

AGTCAACTCGTAGACCGCTATCGTGGTCAGTTAGCTCTATACGAAGAGGCTTTATCACGAGCCTATTCGATTGAAA

ATATTGAAAAATACTTGATTTTACTCGGTAAAGACGAGGTTCAAGTTGTAAAAGTATAA

4109.1

ATGGAACTTGCTCGCCATGCTGAAAGCTTGGGAGTAGATGCTATTGCAACGATTCCACCAATTTATTTCCGCTTGC

CAGAATACTCAGTTGCCAAATACTGGAACGATATCAGTTCTGCAGCTCCAAACACAGACTACGTGATTTACAACA

TTCCTCAATTGGCAGGGGTTGCTTTGACTCCAAGCCTTTACACAGAAATGTTGAAAAATCCTCGTGTTATCGGTGT

GAAGAACTCTTCTATGCCAGTTCAAGATATCCAAACCTTTGTCAGCCTTGGTGGAGAAGACCATATCGTCTTTAAT

GGTCCTGATGAGCAGTTCCTAGGAGGACGCCTCATGGGGGCTAGGGCTGGTATCGGTGGTACTTATGGTGCTATGC

CAGAACTCTTCTTGAAACTCAATCAGTTGATTGCGGATAAGGACCTAGAAACAGCGCGTGAATTGCAGTATGCTAT

CAACGCAATCATTGGTAAACTCACTTCTGCTCATGGAAATATGTACGGTGTCATCAAAGAAGTCTTGAAAATCAAT

GAAGGCTTGAATATTGGATCTGTTCGTTCACCATTGACACCAGTGACTGAAGAAGATCGTCCAGTTGTAGAAGCG

GCTGCTGCCTTGATTCGTGAAACCAAGGAGCGCTTCCTCTAA

4110.2

ATGTATAAGACAAAGTGTTTACGAGAGAAGTTAGTATTATTTTTAAAAATTTTCTTCCCAATCCTGATCTACCAAT

TTGCCAATTATTCTGCCTCTTTTGTTGATACTGCAATGACAGGTCAATACAACACTATGGACTTGGCTGGTGTATCT

ATGGCAACCAGTATCTGGAATCCTTTCTTTACATTTCTAACAGGGATTGTGTCAGCCTTGGTGCCTATCATTGGTCA

CCATCTTGGTCGAGGCAAAAAGGAAGAAGTTGCGTCTGATTTTTACCAATTTATTTATTTGGCCTTGGGCCTATCT

GTGGTCTTGCTGGGGATGGTACTTTTCTTGGCACCAATAATCTTGAATCATATTGGGTTAGAAGCAGCAGTAGCGG

CAGTAGCGGTTCGCTATCTTTGGTTTTTATCTATCGGGATTATCCCCTTGTTGCTCTTTAGCGTCATTCGTTCCTTGC

TGGATTCGCTGGGCTTGACCAAACTGTCCATGTACCTCATGCTTTTGTTACTCCCTCTCAATAGCGGATTTAACTAT

CTCTTGATTTACGGTGCCTTTGGTGTTCCAGAACTGGGAGGGGCTGGTGCTGGTTTAGGAACATCCTTGGCCTACT

GGGTCTTGCTTGGGATTTCTGTTCTGGTTTTATTTAAACAGGAGAAGCTCAAAGCCTTACACCTTGAGAAACGAAT

TCCACTTAATATGGATAAAATTAAGGAAGGAGTTCGTTTAGGTCTGCCTATTGGGGGAACTGTCTTCGCGGAAGTG

GCTATCTTTTCAGTGGTTGGCTTGATTATGGCTAAGTTTTCGCCCTTGATTATAGCTAGTCACCAGTCAGCTATGAA

CTTTTCAAGTCTTATGTACGCCTTTCCTATGAGTATCTCATCGGCTATGGCTATTGTCGTTTCCTATGAAGTGGGAG

CCAAGCGATTTGATGATGCGAAAACCTATATTGGTCTAGGAAGATGGACTGCCCTCATTTTTGCGGCCTTCACCTT

AACCTTCCTTTACATTTTTAGGGGAAATGTGGCCAGTCTTTATGGTAACGACCCAAAATTTATCGATTTGACAGTG

CGTTTTTTAACTTATAGTCTTTTCTTCCAGTTAGCAGATACCTTTGCGGCGCCGCTTCAGGGAATTTTGCGGGGGTA

TAAGGATACAGTTATTCCTTTTTACCTTGGTTTGCTTGGTTATTGGGGCGTAGCAATCCCTGTGTACGCTATTTGA

4112.2

ATGAGTACTTTAGCAAAAATAGAAGCGCTCTTGTTTGTAGCGGGTGAAGATGGGATTCGGGTCCGCCAGTTAGCT

GAACTCCTCTCTCTGCCACCGACAGGCATCCAGCAAAGTTTAGGAAAATTAGCCCAGAAGTATGAAAAGGACCCA

GATTCCAGTTTGGCTTTGATTGAGACAAGTGGTGCTTATAGATTGGTGACCAAGCCTCAATTTGCAGAGATTTTGA

AGGAATACTCTAAGGCGCCTATCAACCAGAGCTTGTCTCGGGCTGCCCTTGAGACCTTGTCCATTATTGCCTACAA

ACAGCCGATTACGCGGATAGAAATTGATGCCATCCGTGGAGTTAACTCGAGTGGAGCCTTGGCAAAGTTGCAGGC

TTTTGACCTGATAAAGGAAGACGGGAAAAAGGAAGTATTGGGGCGCCCCAACCTCTATGTGACTACGGATTATTT

CCTAGATTACATGGGGATAAACCATTTAGAAGAATTACCAGTGATTGATGAGCTTGAGATTCAAGCCCAAGAAAG

CCAATTATTTGGTGAAAGGATAGAAGAAGATGAGAATCAATAA

4113.1

ATGGATACGATGATTAGTAGATTTTTTCGCCATTTATTTGAAGCCTTAAAAAGTTTGAAACGAAATGGTTGGATGA

CAGTAGCTGCTGTCAGTTCAGTCATGATTACTTTGACCTTGGTGGCAATATTTGCATCTGTTATTTTCAATACAGCG

AAACTAGCTACAGATATTGAAAATAATGTCCGTGTAGTAGTTTATATCCGAAAGGATGTGGAAGATAATAGTCAG

ACAATTGAAAAAGAAGGTCAAACTGTTACAAATAATGACTACCACAAGGTATATGATTCTTTGAAGAACATGTCT

ACGGTTAAAAGTGTTACCTTTTCAAGTAAAGAAGAACAATATGAAAAATTAACCGAGATAATGGGAGATAACTGG

AAAATCTTTGAAGGAGATGCCAATCCTCTCTATGATGCCTATATTGTAGAGGCAAACACTCCAAATGATGTAAAA

ACTATAGCCGAAGATGCTAAAAAAATTGAAGGTGTCTCTGAGGTTCAAGATGGCGGTGCCAATACAGAAAGACTC

TTCAAGTTAGCTTCATTTATCCGTGTTTGGGGACTAGGGATTGCTGCTTTGTTAATTTTTATCGCAGTTTTCTTGAT

TTCAAATACCATTCGTATTACCATTATTTCCCGCAGTCGCGAAATTCAAATCATGCGCTTGGTCGGAGCTAAAAAC

AGTTATATCCGTGGACCGTTCTTGTTAGAAGGAGCCTTTATCGGTTTATTGGGAGCTATCGCACCATCTGTTTTGGT

CTTTATTGTTTATCAAATTGTTTACCAATCTGTCAACAAATCGTTGGTAGGGCAAAATCTATCCATGATTAGTCCA

GATTTATTTAGTCCGTTGATGATTGCCCTACTATTTGTGATTGGGGTTTTCATTGGTTCATTGGGATCAGGAATATC

CATGCGCCGATTCTTGAAGATTTAG

4117.1

ATGAAGAAAGTAAGATTTATTTTTTTAGCTCTGCTATTTTTCTTAGCTAGTCCAGAGGGTGCAATGGCTAGTGATG

GTACTTGGCAAGGAAAACAGTATCTGA?AAGAAGATGGCAGTCAAGCAGCAAATGAGTGGGTTTTTGATACTCATT

ATCAATCTTGGTTCTATATAAAAGCAGATGCTAACTATGCTGAAAATGAATGGCTAAAGCAAGGTGACGACTATTT

TTACCTCAAATCTGGTGGCTATATGGCCAAATCAGAATGGGTAGAAGACAAGGGAGCCTTTTATTATCTTGACCAA

GATGGAAAGATGAAAAGAAATGCTTGGGTAGGAACTTCCTATGTTGGTGCAACAGGTGCCAAAGTAATAGAAGAC

TGGGTCTATGATTCTCAATACGATGCTTGGTTTTATATCAAAGCAGATGGACAGCACGCAGAGAAAGAATGGCTC

CAAATTAAAGGGAAGGACTATTATTTCAAATCCGGTGGTTATCTACTGACAAGTCAGTGGATTAATCAAGCTTATG

TGAATGCTAGTGGTGCCAAAGTACAGCAAGGTTGGCTTTTTGACAAACAATACCAATCTTGGTTTTACATCAAAGA

AAATGGAAACTATGCTGATAAAGAATGGATTTTCGAGAATGGTCACTATTATTATCTAAAATCCGGTGGCTACATG

GCAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTTTTATCTCAAATTTGATGGGAAAATGGCTGAAAAAGAA

TGGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTCAAATCCGGTGGTTACATGACAGCCAATGAATGGATTT

GGGATAAGGAATCTTGGTTTTATCTCAAATCTGATGGGAAAATAGCTGAAAAAGAATGGGTCTACGATTCTCATA

GTCAAGCTTGGTACTACTTCAAATCCGGTGGTTACATGACAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTT

TTACCTCAAATCTGATGGGAAAATAGCTGAAAAAGAATGGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTC

AAATCTGGTGGCTACATGGCGAAAAATGAGACAGTAGATGGTTATCAGCTTGGAAGCGATGGTAAATGGCTTGGA

GGAAAAACTACAAATGAAAATGCTGCTTACTATCAAGTAGTGCCTGTTACAGCCAATGTTTATGATTCAGATGGTG

AAAAGCTTTCCTATATATCGCAAGGTAGTGTCGTATGGCTAGATAAGGATAGAAAAAGTGATGACAAGCGCTTGG

CTATTACTATTTCTGGTTTGTCAGGCTATATGAAAACAGAAGATTTACAAGCGCTAGATGCTAGTAAGGACTTTAT

CCCTTATTATGAGAGTGATGGCCACCGTTTTTATCACTATGTGGCTCAGAATGCTAGTATCCCAGTAGCTTCTCAT

CTTTCTGATATGGAAGTAGGCAAGAAATATTATTCGGCAGATGGCCTGCATTTTGATGGTTTTAAGCTTGAGAATC

CCTTCCTTTTCAAAGATTTAACAGAGGCTACAAACTACAGTGCTGAAGAATTGGATAAGGTATTTAGTTTGCTAAA

CATTAACAATAGCCTTTTGGAGAACAAGGGCGCTACTTTTAAGGAAGCCGAAGAACATTACCATATCAATGCTCTT

TATCTCCTTGCCCATAGTGCCCTAGAAAGTAACTGGGGAAGAAGTAAAATTGCCAAAGATAAGAATAATTTCTTTG

GCATTACAGCCTATGATACGACCCCTTACCTTTCTGCTAAGACATTTGATGATGTGGATAAGGGAATTTTAGGTGC

AACCAAGTGGATTAAGGAAAATTATATCGATAGGGGAAGAACTTTCCTTGGAAACAAGGCTTCTGGTATGAATGT

GGAATATGCTTCAGACCCTTATTGGGGCGAAAAAATTGCTAGTGTGATGATGAAAATCAATGAGAAGCTAGGTGG

CAAAGATTAG

4119.2

ATGAAAAAAGTATTACAAAAATATTGGGCATGGGCTTTTGTGGTCATCCCCCTCTTGTTACAAGCAATTTTCTTCT

ATGTGCCGATGTTTCAAGGAGCCTTTTACAGTTTTACCAACTGGACAGGATTGACTTATAACTACAAATTTGTTGG

CTTAAACAACTTTAAGCTCCTCTTCATGGATCCAAAATTCATGAATGCGATTGGCTTTACCGCAATCATTGCGATT

GCCATGGTGCTTGGTGAGATTGCACTCGGGATCTTCATTGCGCGTGTCTTGAATTCTAAATCAAAGGCCAAACCT

TCTTCCGTGCTTGGTTCTTCTTCCCAGCTGTTTTATCTGGTTTGACAGTGGCTTTGATCTTCAAGCAAGTCTTCAAC

TACGGTCTTCCAGCGATTGGAAATGCCCTTCATATTGAATTTTTCCAAACCAGTCTTTTAGGGACTAAGTGGGGAG

CAATCTTTGCGGCTGTCTTTGTCCTTCTTTGGCAAGGGGTGGCTATGCCCATTCATCATCTTCCTAGCTGGTTTGCAA

TCTATTCCAACTGAGATTACAGAGGCAGCAAGGATTGATGGTGCGACTAGCAAGCAAGTTTTCTGGAACATTGAA

TTGCCTTACTTGCTACCAAGTGTCTCTATGGTCTTTATCCTAGCCCTAAAAGGTGGGCTGACTGCCTTTGACCAAGT

CTTTGCCATGACCGGTGGTGGTCCAAACAATGCCACAACCTCACTTGGGCTCTTGGTTTATAACTATGCCTTTAAA

AACAACCAATTCGGTTATGCCAATGCCATTGCCGTAATCTTGTTCTTCTTAATTGTAGTGATTTCGATCATCCAATT

GAGAGTATCTAAGAAATTTGAAATTTAA

4119.3

ATGATGAAACAAGATGAAAGAAAAGCCCTGATTGGCAAATACATTCTATTGATTCTAGGATCGGTTCTGATTTTAG

TGCCGCTCCTTGCTACCCTCTTTAGTTCCTTCAAACCCACTAAGGATATTGTAGATAATTTCTTTGGCTTTCCAACC

AACTTCACATGGGACAACTTTAGCCGTCTCTTAGCTGATGGGATTGGAGGCTATTATTGGAACTCTGTCGTCATCA

CTGTCTTGTCTTTACTTGCAGTAATGATCTTTATCCCTATGGCAGCCTACTCCATCGCTCGCAATATGAGTAAAAG

AAAAGCCTTTACCATCATGTATACCCTCTTAATCCTCGGAATCTTCGTACCTTTCCAAGTCATCATGATTCCGATTA

CGGTTATGATGAGTAAACTCGGTTTGGCTAATACCTTTGGTTTGATCTTGCTCTACTTGACCTATGCGATTCCACAG

ACCCTCTTTCTCTATGTTGGCTATATCAAAATCTCGATTCCAGAAAGTCTGGATGAAGCAGCAGAGATCGATGGGG

CTAATCAATTTACAACCTATTTCCGCATCATCTTCCCAATGATGAAACCGATGCATGCGACAACCATGATCATCAA

TGCCCTTTGGTTCTGGAATGACTTCATGTTGCCACTCCTTGTCTTGAACCGGGATTCCAAAATGTGGACTCTGCCTT

TGTTCCAATACAACTACGCAGGCCAATATTTCAACGACTACGGACCAAGCTTTGCCTCTTACGTGGTCGGCATTAT

CAGTATCACCATTGTCTATCTCTTCTTCCAACGCCATATCATTTCAGGAATGAGCAACGGGGCAGTGAAGTAA

4119.4

ATGAAAAGTATTCTTCAGAAAATGGGGGAGCATCCGATGCTGCTTCTTTTTCTTAGCTATAGTACTGTTTATATCCA

TTCTTGCACAAAATTGGATGGGTCTTGTGGCTTCAGTAGGAATGTTTCTATTTACTATTTTCTTTTTGCACTATCAG

TCGATTTTATCCCATAAATTCTTTCGATTGATTTTGCAGTTTGTCTTGTTTGGTAGTGTCTTGTCAGCTGCTTTTGCC

AGTTTAGAACATTTCCAAATTGTGAAGAAATTTAACTATGCTTTTCTTTCACCCAATATGCAGGTGTGGCATCAGA

ACCGGGCAGAAGTGACCTTCTTTAATCCTAATTATTATGGAATTATTTGTTGTTTCTGTATTATGATTGCTTTCTAT

CTGTTTACAACGACCAAGTTGAATTGGTTGAAAGTATTCTGTGTGATTGCAGGCTTTGTTAATCTCTTTGGTTTGAA

CTTTACTCAAAATCGAACTGCCTTTCCTGCTATTATCGCTGGAGCAATTATCTATCTCTTTACGACTATTAAAAACT

GGAAGGCCTTTTGGCTTAGTATTGGGGTCTTCGCGATTGGTTTGAGTTTCCTCTTTTCTAGTGATTTGGGAGTTCGA

ATGGGTACTTTAGACTCTTCTATGGAAGAACGCATTTCTATCTGGGATGCTGGGATGGCCTTGTTTAAGCAAAATC

CTTTTTGGGGTGAAGGGCCATTGACCTATATGAACTCTTATCCTCGGATACATGCTCCTTATCATGAACATGCCCA

CAGTCTTTATATTGATACGATTCTGAGTTACGGAATTGTGGGGACTATTTTATTAGTTTTGTCTTCTGTTGCTCCTG

TTCGCTTGATGATGGATATGAGTCAGGAGTCGGGGAAACGTCCGATTATCGGCCTTTATCTATCTTTCCTTACAGT

GGTTGCTGTGCACGGAATTTTTGACTTGGCTCTCTTCTGGATTCAGTCAGGCTTTATTTTCTTGCTAGTTATGTGCA

GTATTCCATTGGAGCATCGAATGTTGGTATCGGACATGACGGATTAA

4120.1

ATGTCAAAGATGGATGTTCAGAAAATCATTGCACCGATGATGAAGTTTGTGAATATGCGTGGCATTATAGCTCTAA

AAGATGGGATGTTAGCAATTTTGCCATTGACAGTAGTTGGTAGTTTGTTCTTGATTATGGGACAATTGCCGTTCGA

AGGATTAAATAAGAGCATTGCTAGTGTTTTTGGAGCTAATTGGACAGAGCCGTTTATGCAAGTATATTCAGGAACT

TTTGCTATTATGGGTCTAATTTCTTGTTTTTCAATTGCCTATTCTTATGCTAAGAATAGCGGAGTAGAGGCTTTACC

AGCTGGAGTTCTATCTGTATCTGCATTCTTTATTTTGCTAAGATCATCTTATATCCCTAAACAAGGTGAGGCGATTG

GGGACGCTATTAGTAAAGTTTGGTTTGGAGGCCAAGGAATTATCGGTGCTATCATTATAGGTTTGGTAGTAGGAAG

TATTTATACCTTCTTTATAAAGAGAAAAATTGTTATTAAGATGCCAGAACAAGTTCCACAAGCTATTGCCAAACAG

TTTGAAGCAATGATTCCAGCATTTGTAATTTTCTTATCTTCTATGATTGTATATATTTTAGCGAAGTCATTGACTAA

TGGCGGAACATTCATAGAAATGATTTATTCTGCTATTCAAGTTCCGTTGCAAGGTTTAACTGGATCTTTGTATGGT

GCTATTGGAATTGCATTCTTTATATCATTTTTGTGGTGGTTTGGTGTTCATGGGCAATCGGTAGTAAATGGAGTAGT

GACAGCTCTGCTTTTATCTAATCTTGATGCTAATAAAGCTATGTTAGCCTCTGCTAATCTATCATTAGAAAATGGT

GCACATATTGTTACTCAACAATTTTTAGATTCATTTTTAATTCTATCAGGTTCAGGGATTACGTTTGGTCTTGTAGT

TGCCATGCTTTTTGCAGCAAAATCAAAACAATACCAAGCCTTAGGAAAAGTTGCAGCTTTTCCAGCAATATTTAAC

GTAAATGAGCCAGTTGTATTTGGATTTCCGATTGTCATGAATCCAGTTATGTTTGTACCTTTCATTCTTGTTCCTGT

ACTTGCAGCTGTGATAGTATATGGAGCTATTGCAACAGGTTTCATGCAGCCATTCTCAGGGGTAACATTGCCTTGG

AGTACACCAGCTATTTTATCAGGATTTTTGGTGGGTGGATGGCAAGGAGTTATTACTCAGCTGGTGATATTAGCGA

TGTCTACATTGGTTTATTTTCCATTCTTTAAAGTACAGGATCGTTTAGCTTACCAAAATGAAATCAAACAATCTTAG

4121.2

ATGAAGAAAAAGGACTTAGTAGACCAACTAGTCTCAGAGATCGAGACGGGGAAAGTCAGGACACTGGGAATATA

CGGTCATGGAGCTTCAGGTAAATCAACCTTTGCACAGGAATTGTACCAAGCTTTAGATTCTACTACAGTAAATTTG

CTAGAGACAGATCCTTATATCACCTCAGGACGCCATCTGGTAGTACCCAAGGACGCGCCGAATCAAAAGGTGACA

GCCAGTCTGCCAGTGGCGCATGAACTGGAGAGTTTGCAGAGAGATATCCTTgCTTGCAGGCGGGTATGGATGTCTT

GA

4122.1

ATGAAGAAAAGATACCTAGTCTTGACAGCTTTGCTAGCCTTGAGTCTAGCAGCTTGTTCACAAGAAAAAACAAAA

AATGAAGATGGAGAAACTAAGACAGAACAGACAGCCAAAGCTGATGGAACAGTCGGTAGTAAGTCTCAAGGAGC

TGCCCAGAAGAAAGCAGAAGTGGTCAATAAAGGTGATTACTACAGCATTCAAGGGAAATACGATGAAATCATCGT

AGCCAACAAACACTATCCATTGTCTAAAGACTATAATCCAGGGGAAAATCCAACAGCCAAGGCAGAGTTGGTCAA

ACTCATCAAAGCGATGCAAGAGGCAGGTTTCCCTATTAGTGATCATTACAGTGGTTTTAGAAGTTATGAAACTCAG

ACCAAGCTCTATCAAGATTATGTCAACCAAGATGGAAAGGCAGCAGCTGACCGTTACTCTGCCCGTCCTGGCTAT

AGCGAACACCAGACAGGCTTGGCCTTTGATGTGATTGGGACTGATGGTGATTTGGTGACAGAAGAAAAAGCAGCC

CAATGGCTCTTGGATCATGCAGCTGATTATGGCTTTGTTGTCCGTTATCTCAAAGGCAAGGAAAAGGAAACAGGCT

ATATGGCTGAAGAATGGCACCTGCGTTATGTAGGAAAAGAAGCTAAAGAAATTGCTGCAAGTGGTCTCAGTTTGG

AAGAATACTATGGCTTTGAAGGCGGAGACTACGTCGATTAA

4125.6

ATGCGTAAATTCTTAATTATTTTGTTGCTACCAAGTTTTTTGACCATTTCAAAAGTCGTTAGCACAGAAAAAGAAG

TCGTCTATACTTCGAAAGAAATTTATTACCTTTCACAATCTGACTTTGGTATTTATTTTAGAGAAAAATTAAGTTCT

CCCATGGTTTATGGAGAGGTTCCTGTTTATGCGAATGAAGATTTAGTAGTGGAATCTGGGAAATTGACTCCCAAAA

CAAGTTTTCAAATAACCGAGTGGCGCTTAAATAAACAAGGAATTCCAGTATTTAAGCTATCAAATCATCAATTTAT

AGCTGCGGACAAACGATTTTTATATGATCAATCAGAGGTAACTCCAACAATAAAAAAAGTATGGTTAGAATCTGA

CTTTAAACTGTACAATAGTCCTTATGATTTAAAAGAAGTGAAATCATCCTTATCAGCTTATTCGCAAGTATCAATC

GACAAGACCATGTTTGTAGAAGGAAGAGAATTTCTACATATTGATCAGGCTGGATGGGTAGCTAAAGAATCAACT

TCTGAAGAAGATAATCGGATGAGTAAAGTTCAAGAAATGTTATCTGAAAAATATCAGAAAGATTCTTTCTCTATTT

ATGTTAAGCAACTGACTACTGGAAAAGAAGCTGGTATCAATCAAGATGAAAAGATGTATGCAGCCAGCGTTTTGA

AACTCTCTTATCTCTATTATACGCAAGAAAAAATAAATGAGGGTCTTTATCAGTTAGATACGACTGTAAAATACGT

ATCTGCAGTCAATGATTTTCCAGGTTCTTATAAACCAGAGGGAAGTGGTAGTCTTCCTAAAAAAGAAGATAATAA

AGAATATTCTTTAAAGGATTTAATTACGAAAGTATCAAAAGAATCTGATAATGTAGCTCATAATCTATTGGGATAT

TACATTTCAAACCAATCTGATGCCACATTCAAATCCAAGATGTCTGCCATTATGGGAGATGATTGGGATCCAAAAG

AAAAATTGATTTCTTCTAAGATGGCCGGGAAGTTTATGGAAGCTATTTATAATCAAAATGGATTTGTGCTAGAGTC

TTTGACTAAAACAGATTTTGATAGTCAGCGAATTGCCAAAGGTGTTTCTGTTAAAGTAG

CTCATAAAATTGGAGATGCGGATGAATTTAAGCATGATACGGGTGTTGTCTATGCAGATTCTCCATTTATTCTTTCT

ATTTTCACTAAGAATTCTGATTATGATACGATTTCTAAGATAGCCAAGGATGTTTATGAGGTTCTAAAATGA

4125.7

ATGAAAAAACAAAATAATGGTTTAATTAAAAATCCTTTTCTATGGTTATTATTTATCTTTTTCCTTGTGACAGGATT

CCAGTATTTCTATTCTGGGAATAACTCAGGAGGAAGTCAGCAAATCAACTATACTGAGTTGGTACAAGAAATTAC

CGATGGTAATGTAAAAGAATTAACTTACCAACCAAATGGTAGTGTTATCGAAGTTTCTGGTGTCTATAAAAATCCT

AAAACAAGTAAAGAAGAAACAGGTATTCAGTTTTTCACGCCATCTGTTACTAAGGTAGAGAAATTTACCAGCACT

ATTCTTCCTGCAGATACTACCGTATCAGAATTGCAAAAACTTGCTACTGACCATAAAGCAGAAGTAACTGTTAAGC

ATGAAAGTTCAAGTGGTATATGGATTAATCTACTCGTATCCATTGTGCCATTTGGAATTCTATTCTTCTTCCTATTC

TCTATGATGGGAAATATGGGAGGAGGCAATGGCCGTAATCCAATGAGTTTTGGACGTAGTAAGGCTAAAGCAGCA

AATAAAGAAGATATTAAAGTAAGATTTTCAGATGTTGCTGGAGCTGAGGAAGAAAAACAAGAACTAGTTGAAGTT

GTTGAGTTCTTAAAAGATCCAAAACGATTCACAAAACTTGGAGCCCGTATTCCAGCAGGTGTTCTTTTGGAGGGAC

CTCCGGGGACAGGTAAAACTTTGCTTGCTAAGGCAGTCGCTGGAGAAGCAGGTGTTCCATTCTTTAGTATCTCAGG

TTCTGACTTTGTAGAAATGTTTGTCGGAGTTGGAGCTAGTCGTGTTCGCTCTCTTTTTGAGGATGCCAAAAAAGCA

GCACCAGCTATCATCTTTATCGATGAAATTGATGCTGTTGGACGTCAACGTGGAGTCGGTCTCGGCGGAGGTAATG

ACGAACGTGAACAAACCTTGAACCAACTTTTGATTGAGATGGATGGTTTTGAGGGAAATGAAGGGATTATCGTCA

TCGCTGCGACAAACCGTTCAGATGTACTTGACCCTGCCCTTTTGCGTCCAGGACGTTTTGATAGAAAAGTATTGGT

TGGTCGTCCTGATGTTAAAGGTCGTGAAGCAATCTTGAAAGTTCACGCTAAGAATAAGC

CTTTAGCAGAAGATGTTGATTTGAAATTAGTGGCTCAACAAACTCCAGGCTTTGTTGGTGCTGATTTAGAGAATGT

CTTGAATGAAGCAGCTTTAGTTGCTGCTCGTCGCAATAAATCGATAATTGATGCTTCAGATATTGATGAAGCAGAA

GATAGAGTTATTGCTGGACCTTCTAAGAAAGATAAGACAGTTTCACAAAAAGAACGAGAATTGGTTGCTTACCAT

GAGGCAGGACATACCATTGTTGGTCTAGTCTTGTCGAATGCTCGCGTTGTCCATAAGGTTACAATTGTACCACGCG

GCCGTGCAGGCGGATACATGATTGCACTTCCTAAAGAGGATCAAATGCTTCTATCTAAAGAAGATATGAAAGAGC

AATTGGCTGGCTTAATGGGTGGACGTGTAGCTGAAGAAATTATCTTTAATGTCCAAACCACAGGAGCTTCAAACG

ACTTTGAACAAGCGACAAAATGGCACGTGCAATGGTTACAGAGTACGGTATGAGTGAAAAACTTGGCCCAGTAC

AATATGAAGGAAACCATGCTATGCTTGGTGCACAGAGTCCTCAAAAATCAATTTCAGAACAAACAGCTTATGAAA

TTGATGAAGAGGTTCGTTCATTATTAAATGAGGCACGAAATAAAGCTGCTGAAATTATTCAGTCAAATCGTGAAAC

TCACAAGTTAATTGCAGAAGCATTATTGAAATACGAAACATTGGATAGTACACAAATTAAAGCTCTTTACGAAAC

AGGAAAGATGCCTGAAGCAGTAGAAGAGGAATCTCATGCACTATCCTATGATGAAGTAAAGTCAAAAATGAATGA

CGAAAAATAA

4125.10

ATGAGGGAACCAGATTTTTTAAATCATTTTCTCAAGAAGGGATATTTCAAAAAGCATGCTAAGGCGGTTCTAGCTC

TTTCTGGTGGATTAGATTCCATGTTTCTATTTAAGGTATTGTCTACTTATCAAAAAGAGTTAGAGATTGAATTGATT

CTAGCTCATGTGAATCATAAGCAGAGAATTGAATCAGATTGGGAAGAAAAGGAATTAAGGAAGTTGGCTGCTGAA

GCAGAGCTTCCTATTTATATCAGCAATTTTTCAGGAGAATTTTCAGAAGCGCGTGCACGAAATTTTCGTTATGATT

TTTTTCAAGAGGTCATGAAAAAGACAGGTGCGACAGCTTTAGTCACTGCCCACCATGCTGATGATCAGGTGGAAA

CGATTTTTATGCGCTTGATTCGAGGAACTCGCTTGCGCTATCTATCAGGAATTAAGGAGAAGCAAGTAGTCGGAGA

GATAGAAATCATTCGTCCCTTCTTGCATTTTCAGAAAAAAGACTTTCCATCAATTTTTCACTTTGAAGATACATCA

AATCAGGAGAATCATTATTTTCGAAATCGTATTCGAAATTCTTACTTACCAGAATTGGAAAAAGAAAATCCTCGAT

TTAGGGATGCAATCTTAGGCATTGGCAATGAAATTTTAGATTATGATTTGGCAATAGCTGAATTATCTAACAATAT

TAATGTGGAAGATTTACAGCAGTTATTTTCTTACTCTGAGTCTACACAAAGAGTTTTACTTCAAACTTATCTGAATC

GTTTTCCAGATTTGAATCTTACAAAAGCTCAGTTTGCTGAAGTTCAGCAGATTTTAAAATCTAAAAGCCAGTATCG

TCATCCGATTAAAAATGGCTATGAATTGATAAAAGAGTACCAACAGTTTCAGATTTGTAAAATCAGTCCGCAGGCT

GATGAAAAGGAAGATGAACTTGTGTTACACTATCAAAATCAGGTAGCTTATCAAGGATATTTATTTTCTTTTGGAC

TTCCATTAGAAGGTGAATTAATTCAACAAATACCTGTTTCACGTGAAACATCCATACACATTCGTCATCGAAAAAC

AGGAGATGTTTTGATTAAAAATGGGCATAGAAAAAAACTCAGACGTTTATTTATTG

ATTTGAAAATCCCTATGGAAAAGAGAAACTCTGCTCTTATTATTGAGCAATTTGGTGAAATTGTCTCAATTTTGGG

AATTGCGACCAATAATTTGAGTAAAAAAACGAAAAATGATATAATGAACACTGTACTTTATATAGAAAAAATAGA

TAGGTAA

4126.1

ATGAAGCGTTCTTCTCTTTTAGTTAGAATGGTTATTTCCATCTTTCTGGTCTTTCTCATTCTCCTAGCTCTGGTTGGA

ACTTTCTACTATCAATCAAGTTCTTCAGCCATTGAGGCCACCATTGAGGGCAACAGCCAAACGACCATCAGCCAG

ACTAGCCACTTTATTCAGTCTTATATCAAAAAACTAGAAACCACCTCGACTGGTTTGACCCAGCAGACGGATGTTC

TGGCCTATGCTGAGAATCCCAGTCAAGACAAGGTCGAGGGAATCCGAGATTTGTTTTTGACCATCTTGAAGTCAGA

TAAGGACTTGAAAACTGTTGTGCTGGTGACCAAATCTGGTCAGGTCATTTCTACAGATGACAGTGTGCAGATGAA

AACTTCCTCTGATATGATGGCTGAGGATTGGTACCAAAAGGCCATTCATCAGGGAGCTATGCCTGTTTTGACTCCA

GCTCGTAAATCAGATAGTCAGTGGGTCATTTCTGTCACTCAAGAACTTGTTGATGCAAAGGGAGCCAATCTTGGTG

TGCTTCGTTTGGATATTTCTTATGAAACTCTGGAAGCCTATCTCAATCAACTCCAGTTGGGGCAGCAGGGCTTTGC

CTTCATTATCAATGAAAACCATGAATTTGTCTACCATCCTCAACACACAGTTTATAGTTCGTCTAGCAAAATGGAG

GCTATGAAACCCTACATCGATACAGGTCAGGGTTATACTCCTGGTCACAAATCCTACGTCAGTCAAGAGAAGATT

GCAGGAACTGATTGGACGGTGCTTGGCGTGTCATCATTGGAAAAGTTAGACCAGGTTCGGAGTCAGCTCTTGTGG

ACCTTGCTTGGGGCCAGTGTCACATCTCTTCTTGTCTGTCTCTGCTTAGTGTGGTTCAGTCTTAAACGCTGGATTGC

TCCTTTGAAGGATTTGAGAGAAACCATGTTGGAAATTGCTTCTGGTGCTCAAAATCTTCGTGCCAAGGAAGTTGGT

GCCTATGAACTGAGAGAAGTAACTCGCCAATTTAATGCTATGTTGGATCAGATTGATCAGTTGATGGTAGCTATTC

GTAGCCAGGAAGAAACGACCCGTCAGTACCAACTTCAAGCCCTTTCGAGCCAGATTAATCCACATTTCCTCTATAA

CACTTTGGACACCATCATCTGGATGGCTGAATTTCATGATAGTCAGCGAGTGGTGCAGGTGACCAAGTCCTTGGCA

ACCTATTTCCGCTTGGCGCTCAATCAAGGCAAGGACTTGATTTGTCTCTCTGACGAAATCAATCATGTCCGCCAGT

ATCTCTTTATCCAGAAACAACGCTATGGAGATAAGCTGGAATACGAAATTAATGAAAATGTTGCCTTTGATAATTT

AGTCTTACCCAAGCTGGTCCTACAACCCCTTGTAGAAAATGCTCTTTACCATGGCATTAAGGAAAAGGAAGGTCA

GGGCCATATTAAACTTTCTGTCCAGAAACAGGATTCGGGATTGGTCATCCGTATTGAGGATGATGGCGTTGGCTTC

CAAGATGCTGGTGATAGTAGTCAAAGTCAACTCAAACGTGGGGGAGTTGGTCTTCAAAATGTCGATCAACGGCTC

AAACTTCATTTTGGAGCCAATTACCATATGAAGATTGATTCTAGACCCCAAAAAGGGACGAAAGTTGAAATATAT

ATAAATAGAATAGAAACTAGCTAA

4126.7

ATGAAGCGTTCTTCTCTTTTAGTTAGAATGGTTATTTCCATCTTTCTGGTCTTTCTCATTCTCCTAGCTCTGGTTGGA

ACTTTCTACTATCAATCAAGTTCTTCAGCCATTGAGGCCACCATTGAGGGCAACAGCCAAACGACCATCAGCCAG

ACTAGCCACTTTATTCAGTCTTATATCAAAAAACTAGAAACCACCTCGACTGGTTTGACCCAGCAGACGGATGTTC

TGGCCTATGCTGAGAATCCCAGTCAAGACAAGGTCGAGGGAATCCGAGATTTGTTTTTGACCATCTTGAAGTCAGA

TAAGGACTTGAAAACTGTTGTGCTGGTGACCAAATCTGGTCAGGTCATTTCTACAGATGACAGTGTGCAGATGAA

AACTTCCTCTGATATGATGGCTGAGGATTGGTACCAAAAGGCCATTCATCAGGGAGCTATGCCTGTTTTGACTCCA

GCTCGTAAATCAGATAGTCAGTGGGTCATTTCTGTCACTCAAGAACTTGTTGATGCAAAGGGAGCCAATCTTGGTG

TGCTTCGTTTGGATATTTCTTATGAAACTCTGGAAGCCTATCTCAATCAACTCCAGTTGGGGCAGCAGGGCTTTGC

CTTCATTATCAATGAAAACCATGAATTTGTCTACCATCCTCAACACACAGTTTATAGTTCGTCTAGCAAAATGGAG

GCTATGAAACCCTACATCGATACAGGTCAGGGTTATACTCCTGGTCACAAATCCTACGTCAGTCAAGAGAAGATT

GCAGGAACTGATTGGACGGTGCTTGGCGTGTCATCATTGGAAAAGTTAGACCAGGTTCGGAGTCAGCTCTTGTGG

ACCTTGCTTGGGGCCAGTGTCACATCTCTTCTTGTCTGTCTCTGCTTAGTGTGGTTCAGTCTTAAACGCTGGATTGC

TCCTTTGAAGGATTTGAGAGAAACCATGTTGGAAATTGCTTCTGGTGCTCAAAATCTTCGTGCCAAGGAAGTTGGT

GCCTATGAACTGAGAGAAGTAACTCGCCAATTTAATGCTATGTTGGATCAGATTGATCAGTTGATGGTAGCTATTC

GTAGCCAGGAAGAAACGACCCGTCAGTACCAACTTCAAGCCCTTTCGAGCCAGATTAATCCACATTTCCTCTATAA

CACTTTGGACACCATCATCTGGATGGCTGAATTTCATGATAGTCAGCGAGTGGTGCAGGTGACCAAGTCCTTGGCA

ACCTATTTCCGCTTGGCGCTCAATCAAGGCAAGGACTTGATTTGTCTCTCTGACGAAATCAATCATGTCCGCCAGT

ATCTCTTTATCCAGAAACAACGCTATGGAGATAAGCTGGAATACGAAATTAATGAAAATGTTGCCTTTGATAATTT

AGTCTTACCCAAGCTGGTCCTACAACCCCTTGTAGAAAATGCTCTTTACCATGGCATTAAGGAAAAGGAAGGTCA

GGGCCATATTAAACTTTCTGTCCAGAAACAGGATTCGGGATTGGTCATCCGTATTGAGGATGATGGCGTTGGCTTC

CAAGATGCTGGTGATAGTAGTCAAAGTCAACTCAAACGTGGGGGAGTTGGTCTTCAAAATGTCGATCAACGGCTC

AAACTTCATTTTGGAGCCAATTACCATATGAAGATTGATTCTAGACCCCAAAAAGGGACGAAAGTTGAAATATAT

ATAAATAGAATAGAAACTAGCTAA

4127.4

ATGTTTTTTAAATTATTAAGAGAAGCTCTTAAAGTCAAGCAGGTTCGATCAAAAATTTTATTTACAATTTTTATCGT

TTTGGTCTTTCGTATCGGAACTAGCATTACAGTTCCTGGTGTGAATGCCAATAGCTTGAATGCTTTAAGTGGATTAT

CCTTCTTAAACATGTTGAGCTTGGTGTCGGGGAATGCCCTAAAAAACTTTTCGATTTTTGCCCTAGGAGTTAGTCC

CTATATCACCGCTTCTATTGTTGTCCAACTCTTGCAAATGGATATTTTACCCAAGTTTGTAGAGTGGGGTAAACAA

GGGGAAGTAGGTCGAAGAAAATTGAATCAAGCTACTCGTTATATTGCTCTAGTTCTCGCTTTTGTGCAATCTATCG

GGATTACAGCTGGTTTTAATACCTTGGCTGGAGCTCAATTGATTAAAACTGCTTTAACTCCACAAGTTTTTCTGAC

GATTGGTATCATCTTAACAGCTGGTAGTATGATTGTCACTTGGTTGGGTGAGCAAATTACAGATAAGGGATACGGA

AACGGTGTTTCCATGATTATCTTTGCCGGGATTGTTTCCTCAATTCCAGAGATGATTCAGGGCATCTATGTGGACT

ACTTTGTGAACGTCCCAAGTAGCCGTATCACTTCATCTATCATTTTCGTAATCATTTTGATTATTACTGTATTGTTG

ATTATTTACTTTACAACTTATGTTCAACAAGCAGAATACAAAATTCCAATCCAATATACTAAGGTTGCACAAGGTG

CTCCATCTAGCTCTTACCTTCCGTTAAAAGTAAACCCTGCTGGAGTTATCCCTGTTATCTTTGCCAGTTCGATTACT

GCAGCGCCTGCGGCTATTCTTCAGTTTTTGAGTGCCACAGGTCATGATTGGGCTTGGGTAAGGGTAGCACAAGAGA

TGTTGGCAACTACTTCTCCAACTGGTATTGCCATGTATGCTTTGTTGATTATTCTCTTTACATTCTTCTATACGTTTG

TACAGATTAATCCTGAAAAAGCAGCAGAGACCTACAAAAGAGTGGTGCCTATATCCATGGAGTTCGTCCTGGTAA

AGGTACAGAAGAATATATGTCTAAACTTCTTCGTCGTCTTGCAACTGTTGGTTCCCTCTTCCTTGGTGTGA

4127.5

ATGGATATTAGACAAGTTACTGAAACCATCGCCATGATTGAGGAGCAAAACTTCGATATTAGAACCATTACCATG

GGGATTTCTCTTTTGGACTGTATCGATCCAGATATCAATCGTGCTGCGGAGAAAATCTATCAAAAAATTACGACAA

AGGCGGCTAATTTAGTAGCTGTTGGTGATGAAATTGCGGCTGAGTTGGGAATTCCTATCGTTAATAAGCGTGTATC

GGTGACACCTATTTCTCTGATTGGGGCAGCGACAGATGCGACGGACTACGTGGTTCTGGCAAAAGCGCTTGATAA

GGCTGCGAAAGAGATTGGTGTGGACTTTATTGGTGGTTTTTCTGCCTTAGTACAAAAAGGTTATCAAAAGGGAGAT

GAGATTCTCATCAATTCCATTCCTCGCGCTTTGGCTGAGACGGATAAGGTCTGCTCGTCAGTCAATATCGGCTCAA

CCAAGTCTGGTATTAATATGACGGCTGTGGCAGATATGGGACGAATTATCAAGGAAACAGCAAATCTTTCAGATA

TGGGAGTGGCCAAGTTGGTTGTATTCGCTAATGCTGTTGAGGACAATCCATTTATGGCGGGTGCCTTTCATGGTGT

TGGGGAAGCAGATGTTATCATCAATGTCGGAGTTTCTGGTCCTGGTGTTGTGAAACGTGCTTTGGAAAAAGTTCGT

GGACAGAGCTTTGATGTAGTAGCCGAAACAGTTAAGAAAACTGCCTTTAAAATCACTCGTATCGGTCAATTGGTTG

GTCAAATGGCCAGTGAGAGACTGGGTGTGGAGTTTGGTATTGTGGACTTGAGTTTGGCACCAACCCCTGCGGTTGG

AGACTCTGTGGCACGTGTCCTTGAGGAAATGGGGCTAGAAACAGTTGGCACGCATGGAACGACGGCTGCCTTGGC

CCTCTTGAACGACCAAGTTAAAAAGGGTGGAGTGATGGCCTGCAACCAAGTCGGTGGTTTATCTGGTGCCTTTATC

CCTGTTTCTGAGGATGAAGGAATGATTGCTGCAGTGCAAAATGGCTCTCTTAATTTAGAAAAACTAGAAGCTATGA

CGGCTATCTGTTCTGTTGGATTGGATATGATTGCCATCCCAGAAGATACGCCTGCTGAAACTATTGCGGCTATGAT

TGCGGATGAAGCAGCAATCGGTGTTATCAACATGAAAACAACAGCTGTTCGTATCATTCCCAAAGGAAAAGAAGG

CGATATGATTGAGTTTGGTGGTCTATTAGGAACTGCACCCGTTATGAAGGTTAATGGGGCTTCGTCTGTCGACTTC

ATCTCTCGCGGTGGACAAATCCCAGCACCAATTCATAGTTTTAAAAATTAA

4128.1

ATGACACAGATTATTGATGGGAAAGCTTTAGCGGCCAAATTGCAGGGGCAGTTGGCTGAAAAGACTGCAAAATTA

AAGGAAGAAACAGGTCTAGTGCCTGGTTTGGTAGTGATTTTGGTTGGGGACAATCCAGCCAGCCAAGTCTACGTT

CGCAACAAGGAGAGGTCAGCCCTTGCGGCTGGTTTCCGTAGCGAAGTAGTACGGGTTCCAGAGACCATTACTCAA

GAGGAATTGTTAGACCTGATTGCTAAATACAATCAGGATCCAGCTTGGCATGGGATTTTGGTTCAGTTGCCATTAC

CAAAACACATTGATGAAGAGGCGGTTCTATTGGCTATTGACCCAGAAAAGGATGTGGATGGTTTCCATCCTCTAA

ACATGGGGCGTCTTTGGTCTGGTCATCCAGTCATGATTCCTTCGACACCGGCAGGAATTATGGAAATGTTCCATGA

ATATGGGATTGACTTGGAAGGTAAAAATGCAGTCGTCATCGGTCGATCCAATATTGTCGGAAAACCTATGGCCCA

GCTTCTTTTGGCAAAGAATGCAACAGTAACCTTGACTCACTCACGTACTCATAATCTTTCCAAGGTGGCTGCAAAA

GCAGATATTCTGGTTGTTGCAATCGGTCGTGCCAAGTTTGTGACTGCTGACTTTGTCAAACCAGGTGCGGTAGTCA

TTGACGTTGGGATGAACCGCGATGAAAATGGTAAGCTCTGTGGGGATGTTGATTATGAGGCGGTTGCCCCACTTGC

TAGCCACATTACGCCAGTCCCTGGAGGTGTCGGTCCTATGACCATTACTATGCTGATGGAGCAAACCTATCAGGCA

GCACTTAGGACATTGGATAGAAAATAA

4128.2

ATGTCTAAATTTAATCGTATTCATTTGGTGGTACTGGATTCTGTAGGAATCGGTGCAGCACCAGATGCTAATAACT

TTGTCAATGCAGGGGTTCCAGATGGAGCTTCTGACACACTGGGACACATTTCAAAAACAGTTGGTTTGAATGTCCC

AAACATGGCTAAAATAGGTCTTGGAAATATTCCTCGTGAAACTCCTCTTAAGACTGTAGCAGCTGAAAGCAATCC

AACTGGATATGCAACAAAATTAGAGGAAGTATCTCTTGGTAAGGATACTATGACTGGACACTGGGAAATCATGGG

ACTCAACATTACTGAGCCTTTCGATACTTTCTGGAACGGATTCCCAGAAGAAATCCTGACAAAAATCGAAGAATTC

TCAGGACGCAAGGTTATTCGTGAAGCCAACAAACCTTATTCAGGAACGGCTGTTATCTATGATTTTGGACCACGTC

AGATGGAAACTGGAGAGTTGATTATCTATACTTCAGCTGACCCTGTTTTGCAGATTGCTGCCCACGAAGACATTAT

TCCTTTGGATGAATTGTACCGTATCTGTGAATACGCTCGTTCGATTACCCTTGAGCGTCCTGCCCTTCTTGGTCGCA

TCATTGCTCGCCCTTATGTAGGTGAACCAGGTAACTTCACTCGTACGGCAAACCGTCGTGACTTGGCTGTATCTCC

ATTTTTCCCAACTGTTTTGGATAAATTGAATGAGGCTGGTATCGATACTTATGCTGTGGGTAAAATCAACGATATC

TTTAACGGTGCTGGTATCAACCATGACATGGGTCACAACAAGTCAAATAGTCATGGAATTGATACACTATTGAAG

ACTATGGGACTTGCTGAGTTTGAAAAAGGATTCTCATTCACAAACCTAGTTGACTTTGATGCCCTTTACGGCCATC

GTCGTAATGCTCACGGTTACCGTGATTGCTTGCATGAGTTTGATGAACGCTTACCTGAAATTATCGCAGCTATGAG

AGAGAATGACCTTCTCTTGATTACTGCGGACCATGGAAATGACCCAACGTATGCAGGAACGGATCACACTCGGGA

ATATATTCCATTGTTGGCCTATAGCCCTGCCTTTAAAGGAAATGGTCTCATTCCAGTAGGACATTTTGCAGATATTT

CAGCGACTGTTGCCGATAACTTTGGTGTGGAAACTGCTATGATTGGGGAAAGTTTCTTAGATAAATTGGTATAA

4129.2

ATGTTTATTTCCATCAGTGCTGGAATTGTGACATTTTTACTAACTTTAGTAGAAATTCCGGCCTTTATCCAATTTTA

TAGAAAGGCGCAAATTACAGGCCAGCAGATGCATGAGGATGTCAAACAGCATCAGGCAAAAGCTGGGACTCCTA

CAATGGGAGGTTTGGTTTTCTTGATTACTTCTGTTTTGGTTGCTTTCTTTTTCGCCCTATTTAGTAGCCAATTCAGCA

ATAATGTGGGAATGATTTTGTTCATCTTGGTCTTGTATGGCTTGGTCGGATTTTTAGATGACTTTCTCAAGGTCTTT

CGTAAAATCAATGAGGGGCTTAATCCTAAGCAAAAATTAGCTCTTCAGCTTCTAGGTGGAGTTATCTTCTATCTTT

TCTATGAGCGCGGTGGCGATATCCTGTCTGTCTTTGGTTATCCAGTTCATTTGGGATTTTTCTATATTTTTCTTCGCT

CTTTTCTGGCTAGTCGGTTTTTCAAACGCAGTAAACTTGACAGACGGTGTTGACGGTTTAGCTAGTATTTCCGTTGT

GATTAGTTTGTCTGCCTATGGAGTTATTGCCTATGTGCAAGGTCAGATGGATATTCTTCTAGTGATTCTTGCCATGA

TTGGTGGTTTGCTCGGTTTCTTCATCTTTAACCATAAGCCTGCCAAGGTCTTTATGGGTGATGTGGGAAGTTTGGCC

CTAGGTGGGATGCTGGCAGCTATCTCTATGGCTCTCCACCAAGAATGGACTCTCTTGATTATCGGAATTGTGTATG

TTTTTGAAACAACTTCTGTTATGATGCAAGTCAGTTATTTCAAACTGACAGGTGGTAAACGTATTTTCCGTATGAC

GCCTGTACATCACCATTTTGAGCTTGGGGGATTGTCTGGTAAAGGAAATCCTTGGAGCGAGTGGAAGGTTGACTTC

TTCTTTTGGGGAGTGGGACTTCTAGCAAGTCTCCTGACCCTAGCAATTTTATATTTGATGTAA

4133.1

TTGTTTAAGAAAAATAAAGACATTCTTAATATTGCATTGCCAGCTATGGGTGAAAACTTTTTGCAGATGCTAATGG

GAATGGTGGACAGTTATTTGGTTGCTCATTTAGGATTGATAGCTATTTCAGGGGTTTCAGTAGCTGGTAATATTAT

CACCATTTATCAGGCGATTTTCATCGCTCTGGGAGCTGCTATTTCCAGTGTTATTTCAAAAAGCATAGGGCAGAAA

GACCAGTCGAAGTTGGCCTATCATGTGACTGAGGCGTTGAAGATTACCTTACTATTAAGTTTCCTTTTAGGATTTTT

G?TCCATCTTCGCTGGGAAAGAGATGATAGGACTTTTGGGGACGGAGAGGGATGTAGCTGAGAGTGGTGGACTGTA

TCTATCTTTGGTAGGCGGATCGATTGTTCTCTTAGGTTTAATGACTAGTCTAGGAGCCTTGATTCGTGCAACGCAT

AATCCACGTCTGCCTCTCTATGTTAGTTTTTTATCCAATGCCTTGAATATTCTTTTTTCAAGTCTAGCTATTTTTGTT

CTGGATATGGGGATAGCTGGTGTTGCTTGGGGGACAATTGTGTCTCGTTTGGTTGGTCTTGTGATTTTGTGGTCAC

AATTAAAACTGCCTTATGGGAAGCCAACTTTTGGTTTAGATAAGGAACTGTTGACCTTGGCTTTACCAGCAGCTGG

AGAGCGACTTATGATGAGGGCTGGAGATGTAGTGATCATTGCCTTGGTCGTTTCTTTTGGGACGGAGGCAGTTGCT

GGGAATGCAATCGGAGAAGTCTTGACCCAGTTTAACTATATGCCTGCCTTTGGCGTCGCTACGGCAACGGTCATGC

TGTTGGCCCGAGCAGTTGGAGAGGATGATTGGAAAAGAGTTGCTAGTTTGAGTAAACAAACCTTTTGGCTTTCTCT

GTTCCTCATGTTGCCCCTGTCCTTTAGTATATATGTCTTGGGTGTACCATTAACTCATCTCTATACGACTGATTCTC

TAGCGGTGGAGGCTAGTGTTCTAGTGACACTGTTTTCACTACTTGGGACCCCTATGACGACAGGAACAGTCATCTA

TACGGCAGTCTGGCAGGGATTAGGAAATGCACGCCTCCCTTTTTATGCGACAAGTATAGGAATGTGGTGTATCCGC

ATTGGGACAGGATATCTGATGGGGATTGTGCTTGGTTGGGGCTTGCCTGGTATTTGGGCAGGGTCTCTCTTGGATA

ATGGTTTTCGCTGGTTATTTCTACGCTATCGTTACCAGCGCTATATGAGCTTGAAAGGATAG

4135.2

ATGCAAACTCAAGAAAAACACTCGCAAGCAGCCGTTCTTGGCTTGCAGCACTTACTAGCCATGTACTCAGGATCT

ATCCTGGTTCCCATCATGATTGCGACAGCCCTTGGCTATTCAGCTGAGCAGTTGACCTACCTGATTTCTACAGATA

TCTTCATGTGTGGGGTGGCAACCTTCCTCCAACTCCAACTCAACAAATACTTTGGGATTGGACTCCCAGTCGTTCT

TGGAGTTGCATTCCAGTCGGTCGCTCCCTTGATTATGATTGGGCAAAGCCATGGTAGTGGCGCTATGTTTGGTGCC

CTTATCGCATCTGGGATTTACGTGGTTCTTGTTTCAGGCATCTTCTCAAAAGTAGCCAATCTCTTCCCATCTATCGT

AACAGGATCTGTTATTACCACGATTGGTTTAACCTTGATCCCTGTCGCTATTGGAAATATGGGAAATAACGTTCCA

GAGCCAACTGGTCAAAGTCTCTTGCTTGCAGCTATTACTGTTCTGATTATCCTCTTGATCAACATCTTTACCAAAG

GATTTATCAAGTCTATCTCTATTTTGATTGGTCTGGTTGTTGGAACTGCCATTGCTGCTACTATGGGCTTGGTGGAC

TTCTCTCCTGTTGCGGTAGCTCCACTTGTCCATGTCCCAACTCCACTCTACTTTGGGATGCCAACCTTTGAAATCTC

ATCTATTGTCATGATGTGTATCATCGCAACGGTGTCTATGGTTGAGTCAACTGGTGTTTATCTGGCCTTGTCTGATA

TCACAAAGGATCCAATCGACAGCACGCGCCTTCGCAACGGATACCGCGCAGAAGGTTTGGCCGTACTTCTCGGAG

GAATCTTTAACACCTTCCCTTACACCGGATTTTCACAAAACGTTGGTTTGGTTAAATTGTCAGGCATCAAAAAACG

CCTGCCAATCTACTACGCAGCTGGTTTCCTGGTTCTCCTTGGACTGCTTCCTAAGTTTGGCGCCCTTGCCCAAATCA

TTCCAAGCTCCGTCCTCGGTGGTGCCATGCTGGTAATGTTTGGTTTTGTATCAATTCAAGGGATGCAAATCCTCGC

CCGTGTTGACTTTGCTAACAATGAACACAACTTCCTTATCGCAGCTGTTTCAATCGCTGCAGGTGTCGGTCTCAAC

AACAGTAATCTCTTTGTCAGCATGCCGACAGCCTTCCAAATGTTCTTCTCAAACGGAATCGTCGTAGCCAGCCTAC

TCGCTATTGTCCTCAATGCCGTATTAAATCATAAAAAGAAATAA

4136.2

ATGAAAGATAGAATAAAAGAATATTTACAAGACAAGGGAAAGGTGACTGTTAATGATTTGGCTCAGGCTTTGGGA

AAAGACAGTTCCAAGGATTTTCGTGAGTTGATTAAAACCTTGTCCTTAATGGAAAGAAAGCACCAAATTCGTTTTG

AAGAAGATGGTAGTCTGACATTAGAAATTAAGAAAAAACATGAGATTACCCTCAAGGGGATTTTTCATGCCCATA

AAAATGGCTTTGGCTTTGTTAGTCTGGAAGGCGAGGAGGACGACCTTTTTGTAGGGAAAAATGATGTCAACTATGC

TATTGATGGTGATACCGTCGAGGTAGTGATTAAGAAAGTCGCTGACCGCAATAAGGGAACAGCAGCAGAAGCCAA

AATTATTGATATCCTAGAACACAGTTTGACAACAGTTGTCGGGCAAATCGTTCTGGATCAGGAAAAACCTAAGTAT

GCTGGCTATATTCGTTCAAAAAATCAGAAAATCAGTCAACCGATTTATGTTAAGAAACCAGCCCTAAAATTAGAA

GGAACAGAAGTTCTCAAAGTCTTTATCGATAAATACCCAAGCAAGAAACATGATTTCTTTGTCGCGAGTGTTCTCG

ATGTAGTGGGACACTCAACGGATGTCGGAATTGATGTTCTTGAGGTCTTGGAATCAATGGACATTGTATCCGAGTT

TCCAGAAGCTGTTGTTAAGGAAGCAGAAAGTGTGCCTGATGCTCCGTCTCAAAAGGATATGGAAGGTCGTCTGGA

TCTAAGAGATGAAATTACCTTTACCATTGACGGTGCGGATGCCAAGGACTTGGACGATGCAGTGCATATCAAGGC

TCTGAAAAATGGCAATCTGGAGTTTGGGGTTCACATCGCAGATGTTTCTTATTATGTGACCGAGGGGTCTGCCCTT

GACAAGGAAGCCCTTAACCGTGCGACTTCTGTTTACGTGACAGACCGAGTGGTGCCAATGCTTCCAGAACGACTA

TCAAATGGCATCTGCTCTCTCAATCCCCAAGTTGACCGCCTGACCCAGTCTGCTATTAT

GGAGATTGATAAACATGGTCGTGTGGTCAACTATACCATTACACAAACAGTTATCAAGACCAGTTTTCGTATGACC

TATAGCGATGTCAATGATATCCTAGCTGGCGATGAAGAAAAGAGAAAAGAATATCATAAAATTGTATCAAGTATC

GAACTCATGGCCAAGCTTCATGAAACTTTAGAAAACATGCGTGTGAAACGTGGAGCTCTCAATTTTGATACCAATG

AAGCGAAGATTTTAGTGGATAAACAAGGTAAGCCTGTTGATATCGTTCTTCGGCAGCGTGGTATTGCCGAGCGGA

TGATTGAGTCTTTTATGTTGATGGCTAATGAAACAGTTGCCGAACATTTCAGCAAGTTGGATTTGCCTTTTATCTAT

CGAATTCACGAGGAGCCTAAGGCTGAAAAGGTTCAGAAGTTTATTGATTATGCTTCGAGTTTTGGCTTGCGCATTT

ATGGAACTGCCAGTGAGATTAGTCAGGAGGCACTTCAAGACATCATGCGTGCTGTTGAGGGAGAACCTTATGCAG

ATGTATTGTCCATGATGCTTCTTCGCTCTATGCAGCAGGCTCGTTATTCGGAGCACAATCACGGCCACTATGGACT

AGCTGCTGACTATTATACTCACTTTACCAGTCCAATTCGTCGTTATCCAGACCTTCTTGTTCACCGTATGATTCGGG

ATTACGGCCGTTCTAAGGAAATAGCAGAGCATTTTGAACAAGTGATTCCAGAGATTGCGACCCAGTCTTCCAACC

GTGAACGTCGTGCCATAGAAGCTGAGCGTGAAGTCGAAGCCATGAAAAAGGCTGAGTATATGGAAGAATACGTGG

GTGAAGAGTATGATGCAGTTGTATCAAGTATTGTCAAATTCGGTCTCTTTGTCGAATTGCCAAACACAGTTGAAGG

CTTGATTCACATCACTAATCTGCCTGAATTTTATCATTTCAATGAGCGTGATTTGACTCTTCGTGGAGAAAAATCA

GGTATCACTTTCCGAGTGGGTCAGCAGATCCGTATCCGTGTTGAAAGAGCGGATAAAATGACTGGAGAGATTGAT

TTTTCATTCGTACCTAGTGAGTTTGATGTGATTGAAAAAGGCTTGAAACAGTCTAGTCGT

AGTGGCAGAGGGCGTGATTCAAATCGTCGTTCGGATAAGAAGGAAGACAAGAGAAAATCAGGACGCTCAAATGA

TAAGCGTAAGCATTCACAAAAAGACAAGAAGAAAAAAGGAAAGAAACCTTTTTACAAGGAAGTAGCTAAGAAAG

GAGCCAAGCATGGCAAAGGGCGAGGGAAAGGTCGTCGCACAAAATAA

4137.2

ATGGGCACAACAGGATTTACAATAATTGACTTAATTATCTTGATTGTTTATTTACTTGCGGTGTTGGTTGCAGGTAT

CTATTTCTCTAAAAAAGAGATGAAAGGAAAAGAGTTCTTTAAAGGAGATGGTTCGGTTCCTTGGTATGTTACTTCG

GTATCCATTTTTGCCACAATGCTCAGTCCGATTTCCTTCTTGGGACTCGCTGGTAGCTCTTATGCAGGTAGCTGGAT

TTTATGGTTTGCTCAATTAGGGATGGTAGTAGCTATTCCACTGACAATTCGTTTTATCTTACCTATCTTTGCACGGA

TAGACATCGATACGGCATATGATTACTTGGATAAACGTTTTAATTCTAAAGCACTTCGTATTATTTCAGCACTCTT

GTTTATTATTTATCAATTGGGACGTATGTCTATCATTATGTACCTCCCATCAGCTGGTTTATCAGTATTGACAGGAA

TTGACATCAATATTTTGATTATTTTGATGGGTGTAGTTGCAATTGTTTATTCTTATACTGGTGGTCTAAAATCCGTA

TTATGGACAGACTTTATTCAAGGTGTGATTCTGATTAGTGGTGTCGTTTTAGCTTTATTTGTACTGATTGCTAATAT

TAAAGGTGGCTTTGGTGCAGTAGCAGAAACATTAGCAAACGGGAAATTCCTTGCTGCAAATGAAAAACTTTTCGA

TCCTAACTTGCTTTCAAACTCCATCTTTTTAATTGTGATGGGTTCAGGCTTTACAATCTTGTCTTCCTATGCTTCATC

TCAAGATTTGGTTCAACGTTTTACTACAACACAAAATATTAAGAAACTTAATAAGATGTTGTTCACAAACGGTGTT

TTGTCACTTGCAACTGCAACAGTCTTTTACTTGATTGGTACAGGCTTGTACGTATTCTATCAAGTACAAAATGCAG

ATAGTGCAGCTAGCAATATCCCTCAAGACCAAATCTTTATGTACTTTATTGCATACCAGTTACCAGTAGGTATCAC

AGGTTTGATCTTGGCAGCGATTTATGCAGCATCTCAATCAACTATTTCAACAGGTTTGAACTCTGTTGCAACTTCA

TGGACATTGGATATTCAAGATGTCATTTCTAAAAATATGTCAGACAATCGTCGTACGAAAATTGCACAATTCGTAT

CTCTAGCAGTAGGTTTATTCTCAATTGGTGTTTCCATTGTCATGGCTCACTCAGATATTAAATCTGCATACGAATGG

TTCAATAGTTTCATGGGACTTGTACTTGGTCTACTTGGTGGTGTATTTATTCTTGGATTTGTTTCTAAAAAAGCAAA

TAAACAAGGTGCTTATGCAGCGCTGATTGTATCAACCATCGTCATGGTATTTATTAAATACTTCCTTCCTCCAACA

GCTGTTAGCTACTGGGCATATTCATTGATTTCAATCTCTGTATCAGTAGTTTCAGGTTATATTGTATCTGTTCTTAC

TGGAAATAAAGTATCTGCACCTAAATATACAACGATTCATGATATTACAGAAATTAAAGCGGATTCAAGTTGGGA

AGTTCGTCACTAA

4138.1

ATGAAATTTAGTAAAAAATATATAGCAGCTGGATCAGCTGTTATCGTATCCTTGAGTCTATGTGCCTATGCACTAA

ACCAGCATCGTTCGCAGGAAAATAAGGACAATAATCGTGTCTCTTATGTGGATGGCAGCCAGTCAAGTCAGAAAA

GTGAAAACTTGACACCAGACCAGGTTAGCCAGAAAGAAGGAATTCAGGCTGAGCAAATTGTAATCAAAATTACAG

ATCAGGGCTATGTAACGTCACACGGTGACCACTATCATTACTATAATGGGAAAGTTCCTTATGATGCCCTCTTTAG

TGAAGAACTCTTGATGAAGGATCCAAACTATCAACTTAAAGACGCTGATATTGTCAATGAAGTCAAGGGTGGTTA

TATCATCAAGGTCGATGGAAAATATTATGTCTACCTGAAAGATGCAGCTCATGCTGATAATGTTCGAACTAAAGAT

GAAATCAATCGTCAAAAACAAGAACATGTCAAAGATAATGAGAAGGTTAACTCTAATGTTGCTGTAGCAAGGTCT

CAGGGACGATATACGACAAATGATGGTTATGTCTTTAATCCAGCTGATATTATCGAAGATACGGGTAATGCTTATA

TCGTTCCTCATGGAGGTCACTATCACTACATTCCCAAAAGCGATTTATCTGCTAGTGAATTAGCAGCAGCTAAAGC

ACATCTGGCTGGAAAAAATATGCAACCGAGTCAGTTAAGCTATTCTTCAACAGCTAGTGACAATAACACGCAATC

TGTAGCAAAAGGATCAACTAGCAAGCCAGCAAATAAATCTGAAAATCTCCAGAGTCTTTTGAAGGAACTCTATGA

TTCACCTAGCGCCCAACGTTACAGTGAATCAGATGGCCTGGTCTTTGACCCTGCTAAGATTATCAGTCGTACACCA

AATGGAGTTGCGATTCCGCATGGCGACCATTACCACTTTATTCCTTACAGCAAGCTTTCTGCCTTAGAAGAAAAGA

TTGCCAGAATGGTGCCTATCAGTGGAACTGGTTCTACAGTTTCTACAAATGCAAAACCTAATGAAGTAGTGTCTAG

TCTAGGCAGTCTTTCAAGCAATCCTTCTTCTTTAACGACAAGTAAGGAGCTCTCTTCAGCATCTGATGGTTATATTT

TTAATCCAAAAGATATCGTTGAAGAAACGGCTACAGCTTATATTGTAAGACATGGTGATCATTTCCATTACATTCC

AAAATCAAATCAAATTGGGCAACCGACTCTTCCAAACAATAGTCTAGCAACACCTTCTCCATCTCTTCCAATCAAT

CCAGGAACTTCACATGAGAAACATGAAGAAGATGGATACGGATTTGATGCTAATCGTATTATCGCTGAAGATGAA

TCAGGTTTTGTCATGAGTCACGGAGACCACAATCATTATTTCTTCAAGAAGGACTTGACAGAAGAGCAAATTAAG

GTGCGCAAAAACATTTAG

4139.1

ATGAAAAAAAGAGCAATAGTGGCAGTCATTGTACTGCTTTTGATTGGGCTGGATCAGTTGGTCAAATCCTATATCG

TCCAGCAGATTCCACTGGGTGAAGTGCGCTCCTGGATCCCCAATTTCGTTAGCTTGACCTACCTGCAAAATCGAGG

TGCAGCCTTTTCTATCTTACAAGATCAGCAGCTGTTATTCGCTGTCATTACTCTGGTTGTCGTGATAGGTGCCATTT

GGTATTTACATAAACACATGGAGGACTCATTCTGGATGGTCTTGGGTTTGACTCTAATAATCGCGGGTGGTCTTGG

AAACTTTATTGACAGGGTCAGTCAGGGCTTTGTTGTGGATATGTTCCACCTTGACTTTATCAACTTTGCAATTTTCA

ATGTGGCAGATAGCTATCTGACGGTTGGAGTGATTATTTTATTGATTGCAATGCTAAAAGAGGAAATAAATGGAA

ATTAA

4139.5

ATGAATACAAATCTTGCAAGTTTTATCGTTGGACTGATCATCGATGAAAACGACCGTTTTTACTTTGTGCAAAAGG

ATGGTCAAACCTATGCTCTTGCTAAGGAAGAAGGCCAACATACAGTAGGGGATACGGTCAAAGGTTTTTGCATACA

CGGATATGAAGCAAAAACTCCGCCTGACAACCTTAGAAGTGACTGCCACTCAGGACCAATTTGGTTGGGGACGTG

TCACAGAGGTTCGTAAGGACTTGGGTGTCTTTGTGGATACAGGCCTTCCTGACAAGGAAATCGTTGTGTCACTCGA

TATTCTCCCTGAGCTCAAGGAACTCTGGCCTAAGAAGGGCGACCAACTCTACATCCGTCTTGAAGTGGATAAGAA

AGACCGTATCTGGGGCCTCTTGGCTTATCAAGAAGACTTCCAACGTCTTGCTCGTCCTGCCTACAACAACATGCAG

AACCAAAACTGGCCAGCCATTGTTTACCGTCTCAAGCTGTCAGGAACTTTTGTTTACCTACCAGAAAATAATATGC

TTGGTTTTATTCATCCTAGCGAGCGTTACGCAGAGCCACGTTTGGGGCAAGTATTAGATGCGCGCGTTATTGGTTT

CCGTGAAGTGGACCGCACTCTGAACCTCTCCCTCAAACCACGCTCCTTTGAAATGTTGGAAAACGATGCTCAGATG

ATTTTGACTTATTTGGAAAGCAATGGCGGTTTCATGACCTTAAATGACAAGTCATCTCCAGACGACATCAAGGCAA

CCTTTGGCATTTCTAAAGGTCAGTTCAAGAAAGCTTTAGGTGGTCTTATGAAGGCTGGTAAAATCAAGCAGGACCA

GTTTGGGACAGAGTTGATTTAG

4139.8

ATGAAAGATGTTAGTCTATTTTTATTGAAAAAAGTTTTCAAAAGCCGCTTAAACTGGATTGTCTTAGCTTTATTTGT

ATCTGTACTCGGTGTTACCTTTTATTTAAATAGTCAGACTGCAAACTCACACAGCTTGGAGAGCAGGTTGGAAAGT

CGCATTGCAGCCAACGAGAGGGCTATCAATGAAAATGAAGAGAAACTCTCCCAAATGTCTGATACCAGCTCGGAG

GAATACCAGTTTGCTAAAAATAATTTAGACGTGCAAAAAAATCTTTTGACGCGAAAGACAGAAATTCTGACTTTAT

TAAAAGAAGGGCGCTGGAAAGAAGCCTACTATTTGCAGTGGCAAGATGAAGAGAAGAATTATGAATTTGTATCAA

ATGACCCGACTGCTAGCCCTGGCTTAAAAATGGGGGTTGACCGCGAACGGAAGATTTACCAAGCCCTGTATCCCT

TGAACATAAAAGCACATACTTTGGAGTTTCCGACCCACGGGATTGATCAGATTGTCTGGATTTTAGAGGTTATCAT

CCCAAGTTTGTTTGTGGTTGCTATTATTTTTATGCTAACACAACTATTTGCAGAAAGATATCAAAATCATCTGGAC

ACAGCTCACTTATATCCTGTTTCAAAAGTGACATTTGCAATATCCTCTCTTGGAGTTGGAGTGGGATATGTAACTG

TGCTGTTTATCGGAATCTGTGGCTTTTCTTTTCTAGTGGGAAGTCTGATAAGTGGTTTTGGACAGTTAGATTATCCC

TACCCAATTTATAGCTTAGTGAATCAAGAAGTAACTATTGGGAAAATACAAGATGTATTATTTCCTGGCTTGCTCT

TAGCTTTCTTAGCCTTTATCGTCATTGTGGAAGTTGTGTACTTGATTGCTTACTTTTTCAAGCAAAAAATGCCTGTC

CTCTTTCTTTCACTCATTGGGATTGTTGGCTTATTGTTTGGTATCCAAACCATTCAGCCTCTTCAAAGGATTGCACA

TCTGATTCCCTTTACTTACTTGCGTTCAGTGGAGATTTTATCTGGAAGATTACCTAAGCAGATTGATAATGTCGATC

TAAATTGGAGCATGGGAATGGTCTTACTTCCTTGCCTGATTATCTTTTTGCTATTGGGAATTCTATTTATTGAAAGA

TGGGGAAGTTCACAGAAAAAAGAATTTTTTAATAGATTCTAG

4141.1

ATGATGAAGTTCATATTGGATATTGTTAGTACACCAGCTATTTTAGTAGCTTTAATTGCAATCTTAGGATTAGTTCT

TCAGAAGAAGAAATTACCTGATATTATTAAAGGTGGAATTAAGACCTTTGTTGGTTTCTTAGTTGTATCTGGTGGT

GCAGGAATTGTACAAAATTCTTTAAATCCATTTGGTACCATGTTTGAGCATGCTTTTCATTTATCTGGCGTTGTGCC

GAATAATGAAGCAATTGTAGCTGTAGCTTTAACAACATATGGCTCAGCTACTGCAATGATTATGTTTGCAGGCATG

GTGTTCAATATCTTAATCGCTCGTTTTACTCGATTTAAATATATTTTTTTAACAGGGCACCACACTCTATATATGGC

ATGTATGATTGCGGTCATTTTATCAGTTGCTGGCTTTACTAGCTTGCCTCTCATCTTACTAGGAGGATTAGCACTCG

GTATTATTATGAGTATTTCCCCAGCATTTGTGCAAAAATATATGGTTCAATTAACTGGAAATGACAAGGTAGCTTT

AGGTCATTTCAGTTCTTTGGGATATTGGTTGAGTGGTTTTACTGGTAGCCTTATCGGTGACAAATCAAAATCAACA

GAGGACATTAAATTTCCAAAGAGTTTAGCTTTTTTACGTGATAGTACTGTTAGTATTACTTTATCCATGGCAGTTAT

TTACATTATTGTAGCTATCTTTGCAGGGTCAGAATATATAGAAAAAGAAATCAGTAGTGGTACAAGTGGTCTAGTT

TATGCTTTACAATTAGCAGGTCAATTTGCAGCAGGGGTATTTGTTATTTTTAGCAGGTGTTCGCCTTATTTTGGGCGA

AATTGTTCCAGCCTTTAAAGGTATTTCAGAGCGTCTTGTACCTAATTCAAAACCTGCTTTGGATTGTCCGATTGTTT

ATACTTATGCACCCAATGCAGTTCTAATTGGATTTATCTCTAGTTTTGTTGGTGGTTTAGTAAGTATGGTAATTATG

ATTGCTTCAGGAACGGTTGTTATCTTACCAGGTGTTGTGCCTCATTTCTTCTGTGGAGCGACTGCAGGTGTCATTGG

GAATGCATCTGGTGGTGTTCGTGGAGCCACTATTGGAGCATTTTTACAAGGTATTTTAATCAGTTTTCTTCCAGTCT

TTTTAATGCCAGTTTTGGGAGGACTTGGTTTCCAAGGATCAACTTTCTCAGATGCAGATTTTGGTCTATCAGGAATT

ATTTTAGGAATGTTAAATCAATTTGGCTCACAAGCAGGCATTGTGATTGGTCTTGTTCTTATTCTAGCAGTTATGTT

TGGAGTATCCTTTATTAAAAAGCCATCTGCAACGGAGGAATAA

4142.3

ATGATTAAAACATTTCTCTCTGCCCTTTCGGTCAT?TCTCTTTTCTATCCCTATCATAACTTATTCTTTTTTCCCATCT

TCTAATCTTAACATTTGGCTATCTACCCAACCTATCTTGGCACAGATTTATGCCTTCCCCTTAGCTACTGCAACTAT

GGCTGCTATTTTAAGTTTCTTATTTTTTTTCCTATCTTTTTACAAGAAAAATAAACAAATACGGTTTTACTCTGGCA

TTTTGCTCTTACTATCGCTCATATTACTATTATTCGGAACAGATAAAACCCTTTCTTCTGCATCAAATAAGACTAAA

ACCTTAAAATTAGTAACTTGGAACGTCGCTAATCAAATAGAAGCACAACATATTGAGCGAATTTTTAGCCATTTTG

ACGCCGATATGGCTATATTCCCTGAACTAGCTACCAATATCAGAGGTGAGCAAGAAAACCAGAGAATCAAACTAT

TGTTTCATCAAGTTGGACTTTCTATGGCCAACTATGATATTTTCACTTCTCCACCTACCAATAGTGGAATAGCTCCT

GTGACTGTGATTGTCAAGAAAAGTTATGGTTTCTATACAGAAGCTAAAACTTTTCATACAACACGGTTCGGGACAA

TTGTATTACATTCGAGAAAACAAAATATACCAGATATCATTGCCTTGCATACTGCGCCTCCTCTGCCAGGTTTAAT

GGAAATCTGGAAGCAAGACTTAAACATCATTCATAATCAATTGGCTTCAAAATATCCAAAGGCTATTATTGCAGGT

GATTTTAATGCAACTATGCGTCATGGAGCACTTGCAAAAATAAGCTCTCATAGGGACGCATTAAATGCACTGCCA

CCTTTTGAAAGAGGAACTTGGAATAGCCAAAGTCCAAAACTTTTTAATGCAACAATAGATCATATTTTATTGCCTA

AAAACCACTACTATGTTAAAGATTTAGACATTGTAAGTTTTCAAAACTCTGATCATAGATGTATTTTTACAGAAAT

CACATTTTAA

4142.4

ATGAATCCAATCCAAAGATCTTGGGCTTATGTCAGCAGAAAGCGACTGAGAAGTTTTATTTTATTTCTGATTTTAT

TGGTCTTATTGGCCGGAATTTCAGCCTGTTTGACTCTGATGAAGTCCAACAAAACAGTAGAAAGCAATCTTTATAA

ATCACTCAATACATCTTTTTCTATTAAGAAGATAGAGAATGGTCAGACATTCAAGTTGTCAGACCTAGCATCTGTA

AGCAAGATTAAGGGGCTGGAAAATGTCTCTCCTGAACTTGAGACGGTCGCAAAACTAAAAGACAAGGAAGCAGTG

ACTGGCGAGCAGAGCGTGGAGCGTGATGATTTATCAGCTGCAGACAATAACTTGGTTAGCTTAACGGCTCTTGAG

GATTCATCCAAGGATGTAACCTTTACCAGTTCGGCTTTCAATCTAAAAGAAGGGCGACACCTTCAAAAAGGGGAT

TCCAAGAAAATCCTTATCCACGAAGAATTGGCTAAGAAGAACGGTCTTTCGCTTCATGACAAGATTGGCTTGGATG

CTGGTCAGTCTGAATCTGGAAAAGGACAAACAGTAGAGTTTGAGATTATCGGCATCTTTTCTGGTAAAAAACAAG

AGAAATTCACAGGCTTGTCTTCTGACTTCAGTGAAAATCAAGTCTTTACAGACTATGAAAGTAGCCAAACCCTTTT

GGGCAATAGTGAAGCTCAAGTCAGTGCAGCACGCTTCTATGTAGAAAATCCTAAGGAAATGGACGGACTCATGAA

GCAGGTAGAAAACTTGGCCTTGGAAAATCAAGGCTACCAAGTCGAAAAGGAAAACAAGGCTTTTGAACAAATCAA

AGACTCAGTTGCAACTTTCCAAACCTTCCTGACCATCTTCCTTTATGGGATGTTGATAGCAGGAGCTGGAGCCTTA

ATTCTGGTTTTGTCTCTCTGGTTGAGAGAACGGGTCTATGAAGTGGGGATTTTACTTGCACTTGGAAAAGGCAAGA

GCTCGATCTTCCTACAATTCTGTTTAGAGGTAGTTTTGGTATCTCTTGGAGCTTTGCTTCCAGCATTTGTTGCAGGA

AACGCAATCACAACTTACCTACTCCAAACTCTACTAGCAAGTGGAGATCAGGCAAGCTTACAAGATACACTAGCC

AAAGCAAGCAGTTTATCAACTAGCATCTTATCTTTTGCAGAATCCTATGTTTTTCTAGTTCTGCTTAGTTGCTTATC

TGTAGCCCTTTGTTTCCTATTCTTATTTAGAAAATCACCGAAAGAAATTTTATCATCTATTAGTTAA

4142.5

ATGTTACACAACGCATTTGCCTATGTTACAAGGAAGTTTTTAAATCGATTGTCATCTTCCTGATTATTCTCCTCAT

GGCGAGCTTGAGTTTGGTCGGCTTGTCAATCAAGGGAGCTACTGCCAAGGCTTCTCAGGAGACCTTTAAAAATATC

ACCAATAGCTTCTCCATGCAAATCAATCGTCGCGTCAACCAAGGAACGCCTCGTGGTGCTGGGAATATCAAGGGT

GAAGACATCAAAAAAATCACCGAAAACAAGGCCATTGAGTCTTATGTCAAACGTATCAACGCTATCGGAGATTTG

ACTGGATATGACCTGATTGAAACGCCAGAAACCAAGAAGAATCTCACTGCTGATCGTGCCAAGCGTTTTGGAAGT

AGCTTGATGATTACAGGTGTCAATGACTCCTCTAAAGAAGACAAGTTTGTCTCTGGTTCTTATAAACTAGTCGAAG

GAGAGCACTTAACCAACGACGACAAGGATAAAATCCTCTTGCACAAGGACTTGGCAGCCAAACACGGCTGGAAA

GTAGGGGACAAGGTTAAACTGGACTCTAATATCTACGATGCAGATAATGAAAAAGGAGCCAAGGAAACAGTTGA

AGTGACAATCAAGGGACTCTTTGATGGTCATAATAAGTCAGCAGTAACCTACTCACAAGAACTTTACGAAAACAC

AGCTATTACAGACATTCACACTGCTGCAAAACTTTATGGATACACAGAAGACACAGCCATTTATGGGGACGCAAC

CTTCTTTGTAACAGCAGACAAGAACTTGGATGATGTTATGAAAGAGTTGAATGGCATCAGTGGTATCAACTGGAA

GAGCTACACACTCGTCAAGAGCTCCTCTAACTACCCAGCTCTTGAGCAATCTATCTCTGGTATGTACAAGATGGCC

AACCTCCTCTTCTGGGGTAGCTTGAGCTTCTCAGTTCTCCTCCTTGCCCTCTTGCTCAGCCTTTGGATCAACGCCCG

TCGCAAGGAAGTGGGAATTCTCCTCTCTATCGGCCTCAAGCAGGCAAGTATCTTGGGTCA

ATTCATCACCGAATCTATCTTGATTGCTATCCCTGCTCTAGTTTCTGCTTACTTCCTAGCTAATTACACTGCCCGTG

CAATTGGAAACACTGTCCTTGCCAATGTGACTTCAGGTGTTGCCAAACAGGCTAGTAAGGCGGCTCAAGCCTCTA

ACCTTGGTGGTGGTGCAGAAGTAGATGGCTTTAGCAAGACCTTGTCGAGCCTAGACATTTCCATTCAGACATCAGA

CTTTATCATCATTTTTGTCCTTGCCTTGGTTCTAGTGGTTCTCGTTATGGCGCTTGCTTCAAGCAATCTCCTTAGAA

AACAACCAAAAGAGCTCTTGCTGGATGGTGAATAA

4144.1

ATGTCACAGGATAAACAAATGAAAGCTGTTTCTCCCCTTCTGCAGCGAGTTATCAATATCTCATCGATTGTCGGTG

GGGTTGGGAGTTTGATTTTCTGTATTTGGGCTTATCAGGCTGGGATTTTACAATCCAAGGAAACCCTCTCTGCCTTT

ATCCAGCAGGCAGGCATCTGGGGTCCACCTCTCTTTATCTTTTTACAGATTTTACAGACTGTCGTCCCTATCATTCC

AGGGGCCTTGACCTCGGTGGCTGGGGTCTTTATCTACGGGCACATCATCGGGACTATCTACAACTATATCGGCATC

GTGATTGGCTGTGCCATTATCTTTTATCTAGTGCGCCTATACGGAGCTGCCTTTGTCCAGTCTGTCGTCAGCAAGC

GCACCTACGACAAGTACATCGACTGGCTAGATAAGGGCAATCGTTTTGACCGCTTCTTTATTTTTATGATGATTTG

GCCCATTAGCCCAGCTGACTTTCTCTGTATGCTGGCTGCCCTGACCAAGATGAGCTTCAAGCGCTACATGACCATC

ATCATTCTGACCAAACCCTTTACCCTCGTGGTTTATACCTACGGTCTGACCTATATTATTGACTTTTTCTGGCAAAT

GCTTTGA

4144.2

ATGAGAAATATGTGGGTTGTAATCAAGGAAACCTATCTTCGACATGTCGAGTCATGGAGTTTCTTCTTTATGGTGA

TTTCGCCGTTCCTCTTTTTAGGAATCTCTGTAGGAATTGGGCATCTCCAAGGTTCTTCTATGGCTAAAAATAATAAA

GTGGCAGTAGTGACAACAGTGCCATCTGTAGCAGAAGGACTGAAGAATGTAAATGGTGTTAACTTCGACTATAAA

GACGAAGCAAGTGCCAAAGAAGCAATTAAAGAAGAAAAATTAAAAGGTTATTTGACCATTGATCAAGAAGATAGT

GTTCTAAAGGCAGTTTATCATGGCGAAACATCGCTTGAAAATGGAATTAAATTTGAGGTTACAGGTACACTCAATG

AACTGCAAAATCAGCTTAATCGTTTCAACTGCTTCCTTGTCTCAAGAGCAGGAAAAACGCTTAGCGCAGACAATTC

AATTCACAGAAAAGATTGATGAAGCCAAGGAAAATAAAAAGTTTATTCAAACAATTGCAGCAGGTGCCTTAGGAT

TCTTTCTTTATATGATTCTGATTACCTATGCGGGTGTAACAGCTCAGGAAGTTGCCAGTGAAAAAGGCACCAAAAT

TATGGAAGTCGTTTTTTCTAGCATAAGGGCAAGTCACTATTTCTATGCGCGGATGATGGCTCTGTTTCTAGTGATTT

TAACGCATATTGGGATCTATGTTGTAGGTGGTCTGGCTGCCGTTTTGCTCTTTAAAGATTTGCCATTCTTGGCTCAG

TCTGGTATTTTGGATCACTTGGGAGATGCTATCTCACTGAATACCTTGCTCTTTATTTTGATCAGTCTTTTCATGTA

CGTAGTCTTGGCAGCCTTCCTAGGATCTATGGTTTCTCGTCCTGAGGACTCAGGGAAAGCCTTGTCGCCTTTGATG

ATTTTGATTATGGGTGGTTTTTTTGGAGTGACAGCTCTAGGTGCAGCTGGTGACAATCTCCTCTTGAAGATTGGTTC

TTATATTCCCTTTATTTCGACCTTCTTTATGCCGTTTCGAACGATTAATGACTATGCGGGGGGAGCAGAAGCATGG

ATTTCACTTGCTATTACAGTGATTTTTGCGGTGGTAGCAACAGGATTTATCGGACGCATGTATGCTAGTCTCGTTCT

TCAAACGGATGATTTAGGGATTTGGAAAACCTTTAAACGTGCCTTATCTTATAAATAG

4144.3

ATGACAGAAACCATTAAATTGATGAAGGCTCATACTTCAGTGCGCAGGTTTAAAGAGCAAGAAATTCCCCAAGTA

GACTTAAATGAGATTTTGACAGCAGCCCAGATGGCATCATCTTGGAAGAATTTCCAATCCTACTCTGTGATTGTGG

TACGAAGTCAAGAGAAGAAAGATGCCTTGTATGAATTGGTACCTCAAGAAGCCATTCGCCAGTCTGCTGTTTTCCT

TCTCTTTGTCGGAGATTTGAACCGAGCAGAAAAGGGAGCCCGACTTCATACCGACACCTTCCAACCCCAAGGTGT

GGAAGGTCTCTTGATTAGTTCGGTCGATGCAGCTCTTGCTGGACAAAACGCCTTGTTGGCAGCTGAAAGCTTGGGC

TATGGTGGTGTGATTATCGGTTTGGTTCGATACAAGTCTGAAGAAGTGGCAGAGCTCTTTAACCTACCTGACTACA

CCTATTCTGTCTTTGGGATGGCACTGGGTGTGCCAAATCAACATCATGATATGAAACCGAGACTGCCACTAGAGA

ATGTTGTCTTTGAGGAAGAATACCAAGAACAGTCAACTGAGGCAATCCAAGCTTATGACCGTGTTCAGGCTGACT

ATGCTGGGGCGCGTGCGACCACAAGCTGGAGTCAGCGCCTAGCAGAACAGTTTGGTCAAGCTGAACCAAGCTCAA

CTAGAAAAAATCTTGAACAGAAGAAATTATTGTAG

4146.1

ATGTTAAAACTTATTGCTATTGTTGGAACAAATTCAAAACGTTCTACAAACCGTCAATTGCTTCAATACATGCAAA

AACACTTTACTGACAAAGCTGAAATTGAACTTGTTGAAATCAAGGCCATTCCTGTCTTCAACAAACCAGCTGACAA

GCAAGTACCTGCTGAAATATTGGAAATTGCTGCTAAAATCGAAGAGGCAGATGGCGTTATTATCGGTACTCCTGA

GTATGATCACTCTATTCCAGCTGTTTTGATGAGCGCTCTTGCTTGGTTGTCTTATGGTATTTACCCACTTTTGAACA

AACCAATCATGATTACAGGTGCTTCTTACGGTACGCTTGGTTCATCTCGTGCCCAATTGCAACTTCGTCAAATCTT

GAATGCTCCTGAAATCAAGGCAAATGTTCTTCCAGATGAATTCTTGCTCTCACACTCTCTTCAAGCATTTAACCCA

AGTGGCGACTTGGTTGACCTTGATGTTATCAAGAAATTGGATGCCATCTTTGATGACTTCCGTATCTTTGTAAAAA

TCACAGAAAAATTACGTAATGCACAAGAATTACTTCGCAAAGATGCTGAAGACTTTGACTGGGAAAATTTGTAA

4146.2

ATGAATACCTATCAATTAAATAATGGAGTAGAAATTCCAGTATTGGGATTTGGAACTTTTAAGGCTAAGGATGGA

GAAGAAGCCTATCGTGCAGTGTTAGAAGCCTTGAAGGCTGGTTATCGTCATATTGATACGGCGGCGATTTATCAGA

ATGAAGAAAGTGTTGGTCAAGCAATCAAAGATAGCGGAGTTCCACGTGAAGAAATGTTCGTAACTACCAAGCTTT

GGAATAGTCAGCAAACCTATGAGCAAACTCGTCAAGCTTTGGAAAAATCTATAGAAAAACTGGGCTTGGATTATT

TGGATTTGTATTTGATTCATTGGCCGAACCCAAAACCGCTCAGAGAAAATGACGCATGGAAAACTCGCAATGCGG

AAGTTTGGAGAGCGATGGAAGACCTCTATCAAGAAGGGAAAATCCGTGCTATCGGCGTTAGCAATTTTCTTCCCC

ATCATTTGGATGCCTTGCTTGAAACTGCAACTATCGTTCCTGCGGTCAATCAAGTTCGCTTGGCGCCAGGTGTGTA

TCAAGATCAAGTCGTAGCTTACTGTCGTGAAAAGGGAATTTTATTGGAAGCTTGGGGGCCTTTTGGACAAGGAGA

ACTGTTTGATAGCAAGCAAGTCCAAGAAATAGCAGCAAATCACGGAAAATCGGTTGCTCAGATAGCCTTGGCCTG

GAGCTTGGCAGAAGGATTTTTACCACTTCCAAAATCTGTCACAACCTCTCGTATTCAAGCTAATCTTGATTGCTTT

GGAATTGAACTGAGTCATGAGGAGAGAGAAACCTTAAAAACGATTGCTGTTCAATCGGGTGCTCCACGAGTTGAT

GATGTGGATTTCTAG

4147.1

ATGAGGTGCAAAATGCTTGATCCAATTGCTATTCAACTAGGACCCCTAGCCATTCGTTGGTATGCCTTATGTATTG

TGACAGGCTTGATTCTTGCGGTTTATTTGACCATGAAAGAAGCACCTAGAAAGAAGATCATACCAGACGATATTTT

AGATTTTATCTTAGTAGCCTTTCCCTTGGCTATTTTAGGAGCTCGTCTCTACTATGTTATTTTCCGATTTGATTACTA

TAGTCAGAATTTAGGAGAGATTTTTGCCATTTGGAATGGTGGTTTGGCCATTTACGGTGGTTTGATAACTGGGGCT

CTTGTGCTCTATATCTTTGCTGACCGTAAACTCATCAATACTTGGGATTTTCTAGATATTGCGGCGCCTAGCGTTAT

GATTGCTCAAAGTTTGGGGCGTTGGGGTAATTTCTTTAACCAAGAAGCTTATGGTGCAACAGTGGATAATCTGGAT

TATCTACCTGGCTTTATCCGTGACCAGATGTATATTGAGGGGAGCTACCGTCAACCGACTTTCCTTTATGAGTCTC

TATGGAATCTGCTTGGCTTTGCCTTGATTCTGATTTTTAGACGGAAATGGAAGAGTCTCAGACGAGGTCATATCAC

GGCCTTTTACTTGATTTGGTATGGTTTCGGTCGTATGGTTATCGAAGGTATGCGAACAGATAGTCTCATGTTCTTCG

GCTTTCGAGTGTCCCAATGGCTGTCAGTTGTCCTTATCGGTCTCGGTATAATGATCGTTATTTATCAAAATCGAAA

GAAGGCCCCTTACTATATTACAGAGGAGGAAAACTAA

4147.2

ATGGGTAAATTATCCTCAATCCTTTTAGGAACCGTTTCAGGTGCAGCTCTTGCCTTGTTTTTAACAAGTGATAAGG

GCAAACAAGTTTGCAGTCAGGCTCAAGATTTTCTAGATGATTTGAGAGAAGATCCGGAGTATGCCAAGGAGCAAG

TCTGTGAAAAACTGACAGAAGTTAAGGAGCAGGCTACAGATTTTGTTCTGAAAACAAAGAACAGGTTGAGTCAG

GTGAAATCACTGTGGACAGTATACTTGCTCAAACTAAATCCTATGCTTTTCAAGCGACAGAAGCATCAAAAAATC

AATTAAATAATCTCAAGGAGCAATGGCAAGAAAAAGCCGAAGCTCTTGATGACTCAGAAGAGATTGTGATTGATA

TAACAGAAGAATAA

4147.3

ATGAAAACTAAATTGATCTTTTGGGGCTCTATGCTCTTTCTCCTCTCCCTCTCCATCCTTCTGACCATTTATCTGGC

TTGGATTTTCTATCCTATGGAGATTCAGTGGCTAAACTTAACGAATCGAGTCTATCTAAAACCAGAAACCATTCAA

TACAATTTTCATATCTTGATGAATTATCTGACCAATCCTTTTAGTCAGGTCTTACAGATGCCTGATTTTCGTTCGTC

AGCAGCTGGTCTGCACCATTTCGCAGTGGTCAAGAATCTCTTTCATTTGGTTCAGCTAGTAGCTCTAGTGACACTG

CCAAGTTTCTATGTCTTTGTCAATAGGATTGTGAAAAAGGACTTTTTGTCTCTTTATCGAAAAAGTCTCCTGGCTCT

AGTAGTCTTACCTGTGATGATTGGACTTGGGGGAGTTTTGATTGGTTTTGACCAATTCTTTACTCTTTTCCATCAAA

TTCTCTTTGTGGGAGATGATACCTGGCTTTTTGATCCAGCCAAGGATCCTGTTATTATGATTTTGCCAGAGACCTTC

TTTCTTCATGCCTTCCTCCTCTTTTTTGCCCTCTATGAAAACTTCTTTGGCTATCTGTATCTGAAAAGTCGTAGGAA

GTGA

4149.1

ATGACTTATCATTTTACTGAAGAATACGATATTATTGTAATTGGTGCGGGACACGCTGGGGTTGAGGCTTCCTTGG

CCGCTAGCCGTATGGGCTGTAAGGTCCTGCTTGCGACCATCAATATTGAAATGCTGGCTTTCATGCCTTGTAATCC

CTCTATCGGTGGTTCTGCCAAGGGGATTGTCGTGCGTGAAGTCGATGCCCTCGGTGGCGAGATGGCCAAAACCATT

GACAAGACTTACATCCAGATGAAGATGCTAAACACAGGGAAGGGGCCAGCTGTCCGTGCCCTTCGTGCGCAGGCT

GACAAGGAACTTTACTCTAAGGAGATGCGCAAGACGGTTGAAAACCAAGAAAATCTGACCCTTCGTCAAACCATG

ATTGATGAGATTTTGGTGGAAGATGGCAAGGTTGTCGGTGTGCGTACAGCCACCCATCAAGAATATGCTGCTAAG

GCTGTTATTGTGACGACAGGGACTGCTCTCCGTGGGGAAATTATCATCGGAGACCTCAAGTACTCATCAGGTCCTA

ACCACAGCTTGGCTTCTATTAACCTAGCTGACAATCTCAAGGAACTGGGTCTCGAAATCGGTCGTTTCAAGACAGG

AACCCCTCCACGTGTCAAGGCTTCTTCTATCAATTACGATGTGACAGAAATTCAGCCAGGAGACGAAGTGCCTAAT

CATTTCTCATACACTTCACGTGATGAGGATTATGTCAAGGACCAAGTACCATGCTGGTTGACCTATACCAATGGTA

CCAGTCATGAGATTATCCAAAACAACCTCCACCGTGCGCCTATGTTTACAGGTGTGGTCAAGGGAGTGGGGCCTC

GTTACTGTCCGTCGATTGAAGACAAGATTGTGCGCTTTGCGGACAAGGAACGTCACCAACTCTTCCTTGAGCCAGA

AGGGCGCAATACTGAGGAAGTCTATGTGCAAGGACTTTCAACCAGTCTGCCTGAGGATGTCCAGCGTGACTTGGT

GCATTCCATCAAAGGTTTGGAAAATGCAGAGATGATGCGGACAGGTTATGCTATTGA

GTATGATATGGTCTTGCCTCATCAGTTGCGTGCGACTTTGGAAACCAAGAAAATCTCAGGTCTCTTCACTGCTGGT

CAGACAAATGGAACATCAGGTTACGAAGAGGCAGCAGGCCAAGGGATTATCGCGGGTATCAATGCGGCTCTGAA

AATCCAAGGCAAGCCTGAATTGATTTTGAAGCGCAGTGATGGTTATATCGGGGTGATGATCGACGACTTGGTGAC

CAAGGGAACCATTGAACCCTACCGTCTCTTGACCAGTCGTGCTGAATACCGTCTCATTCTTCGTCATGACAATGCT

GATATGCGCTTGACTGAGATGGGACGCGAGATTGGCCTTGTGGACGATGAACGCTGGGCTCGTTTTGAAATCAAG

AAAAATCAATTTGATAATGAGATGAAGCGCCTAGACAGTATCAAACTCAAGCCAGTCAAGGAAACCAATGCCAAG

GTTGAGGAGATGGGCTTCAAACCCTTGACCGATGCAGTGACAGCCAAGGAATTCCTTCGCCGTCCAGAAGTTTCTT

ACCAAGATGTGGTGGCCTTCATCGGACCAGCTGCAGAAGACTTGGATGACAAGATTATCGAATTGATTGAAACAG

AAATCAAGTATGAAGGCTATATTTCCAAAGCCATGGACCAGGTTGCCAAGATGAAACGCATGGAAGAAAAACGCA

TTCCGGCCAATATCGACTGGGATGACATTGATTCTATCGCAACCGAAGCCCGTCAGAAGTTCAAACTCATCAATCC

AGAAACCATCGGCCAAGCCAGCCGTATTTCGGGAGTAAACCCAGCAGATATTTCTATTTTGATGGTGTATCTGGAA

GGTAAAAATCGTAGTATTTCTAAAACTCTTCAAAAATCAAAATGA

4149.2

ATGAAAGTATTAGCTTTTGATACGTCCAGCAAGGCTCTTTCTCTGGCTATTTTAGAGGATAAGCAGGTTCTTGCCG

AGACGACGATTAATATTAAGAAAAATCACAGTATTACTCTTATGCCTGCCATCGATTTTTTGATGGCAAGTTTGGA

TTGGACACCCAAGGATTTGGACCGAATCGTGGTAGCTGAAGGGCCGGGTAGCTATACAGGCTTGCGAATTGCGGT

AGCAACTGCTAAGACCTTAGCTCACACCCTGAACATCGAGTTGGTTGGTATGTCGAGTCTCTTGGCTCTGGTGCCC

CATCAACAAGAAGGTTTGTTTGTCCCCTTGATGGATGCGGGTCGCAATAATGTTTATGCAGGATTTTATGAAAATG

CCAAACCTGTCATGGCAGAAGCGCACCTATCTTTTGAAGAGGTGCTAGAAAAAGTCAAGGGTACTAGTCAGGTAA

CCTTTGTCGGAGAAGTTGGCCCCTTTGTTGAGCAGATTCAAAAACACTTGCCAAGGACTGATTACAAAGAAACATT

GCCCAATGCAGCTAATCTAGCTCTTTTGGCCTGGGACAAGGAAGCAGACTCCTTGCATGATTTTGTGCCGAATTAC

CTCAAACGAGTCGAGGCTGAGGAAAACTGGCTCAAGAACCATACCGAGTCTGGCGAGTCTTACATTAAACGCCTA

TGA

4149.3

ATGATAGAAATCAAGCGAATTCAACAACAGCCTGACCTAGCTCAAGCCATCTACGCTGTTATGGCAGCTGTTTACC

TAGTCAGTCCTTGGACTCTGGAGCAAATCCAAGCAGATCTGTCCCAAGACCAGACTTGGTATGCATTGGCTTATGA

TGGGGCAGAAGTGATTGGATTTCTAGCTGTGCAGGAGAATCTTTTTGAAGCAGAAGTCCTGCAAATCGCTGTCAA

AGGAGCTTATCAGGGTCAGGGGATTGCGTCagCCTTGTTTGCTCAATTGCCGACAGACAAGGAAATTTTCCTCGAA

GTCAGACAGTCAAATCAACGAGCGCAAGCATTTTACAAGAAAGAAAAGATGACAGTTATCGCTGAGCGAAAGGC

CTACTACCATGACCCAGTCGAGGACGCCATTATCATGAAGAGAGAAATAGATGAAGGATAG

4152.2

ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAA

GGCTTTTCTACTCAATTGGTGACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCT

TGCTTGATATCATGTTACCACAATTAGATGGCATGGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTC

CAATTATGATGGTTTCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCT

GACCAAGCCTTTTAGCCCTAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGA

AGGAGATGATTCAGATAATATCGCTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAA

GTCTACAAGGCGAATAAGTTACTGAGTTTGACCCCAAAAGAATTTGAAAGCGATAAAAATCCGTTTTTTGAAGTTT

TCAAAGTTTCGAAAGTAACCGCCCAATAA

4154.1

ATGACTACTTTTAAAGATGGATTTTTATGGGGTGGTGCTGTTGCTGCTCATCAACTTGAAGGTGGATGGCAAGAAG

GTGGCAAGGGAATTAGTGTTGCTGATGTTATGACTGCTGGTCGTCATGGAGTAGCTCGTGAAATTACTTTGGGAGT

TTTAGAGGGTAAATATTATCCAAATCATGAGGCGATAGATTTTTATCACCGTTATAAAGAAGATATAGCACTTTTT

GCTGAAATGGGATTCAAGTGCTTCCGTACCTCTATTGCATGGACACGTATCTTTCCAAAAGGTGATGAGTTAGAGC

CGAATGAAGAAGGATTACAGTTTTATGATAATCTTTTTGATGAATGCTTAAAGAATGGTATTGAACCTGTCATCAC

TCTATCTCATTTTGAAATGCCTTATCACTTAGTGACCGAATATGGTGGTTGGAAAAATAGGAAATTGATTGATTTC

TTTGCTCGTTTTGCAGAAGTCGTATTTAAACGTTACAAAGATAAGGTTAAATATTGGATGACTTTCAATGAAATCA

ATAATCAAGCGAATTATCAGGAAGATTTTGCACCATTTACTAACTCAGGTATTGTATATGAGGAAGGTGATAATAG

AGAAGCAATTATGTATCAAGCAGCACATTACGAATTAGTTGCTTCTGCACGAGCTGTAAAAATTGGTCATGAGATT

AATCCAGATTTTCAAATAGGTTGTATGATTGCGATGTGTCCAATTTATCCAGTTACTTGCAATCCTAAGGATATCTT

AATGGCAATGAAAGCTATGCAGAAGCGTTATTATTTTGCTGATGTGCATGTTTTAGGTAAATATCCTGAGCATATT

TTCAAGTATTGGGAACGAAAAGGTATTTCAGTTGATTTTACTGCCCAGGATAAAGAAGATTTACTTGGTGGGACTG

TAGATTACATTGGTTTCAGTTACTATATGTCCTTTGCTATCGACTCTCATCGTGAAAATAATCCTTATTTTGATTAT

CTTGAAACAGAAGATTTAGTGAAAAATAATTATGTTAAGGCTTCTGAATGGGAGTGGCAAATTGATCCAGAAGGT

TTGCGTTATGCGTTAAATTGGTTTACAGACCACTATCACTTACCACTCTTTATTGTTGAAAATGGTTTTGGAGCTAT

AGATCAAGTTGCAGCAGATGGTATGGTACATGATGATTATAGAATTGAATATCTAGGTGCCCATATTCGTGAAATG

AAAAAGGCTGTAGTTGAAGATGGTGTTGATTTAATGGGTTATACTCCATGGGGATGTATTGATTTGGTTTCAGCTG

GTACCGGTGAAATGCGGAAACGTTATGGCTTTATTTATGTAGATAAAGATGATAATGGGAAGGGAAGTTATAATC

GTTCCCCGAAAAAATCTTTTGGCTGGTATAAGGAAGTTATTTCATCTAACGGTGAATCAGTAGAATAG

4154.2

ATGGATCAACAAAACGGGTTGTTTGGTTTTCTTGAAAACCATGTTATGGGACCAATGGGCAAACTTGCTCAGTTTA

AAGTAGTACGTGCTATCACGGCTGCAGGTATGGCTGCTGTACCATTTACTATTGTAGGATCAATGTTTTTGGTATT

CAGTATTTTGCCACAAGCTTTCTCATTTTGGCCAATTGTGGCAGATATTTTCTCTGCTTCATTTGATAAATTCACAT

CACTTTACATGGTTGCAAACTATGCGACTATGGGTTCTCTATCTCTTTATTTCGTTCTATCACTTGCATATGAATTG

ACAAAAATTTATGCAGAGGAAGAAGAACTCAATATGAATCCTCTTAATGGTGCCTTGCTTGCCTTGATGGCTTTTG

TCATGACAGTACCGCAAATCATTTTTGATGGTGGAATGATGAAGACTGTGACAAGTCTAAAAGAAGGTGCAGTAA

TTGCAGATGGATGGGCAATGGGAAATGTAGTCGCACGTTTTGGGACAACAGGGATTTTTACCGCAATCATTATGG

CAATTGTGACTGTTCTTATTTATCGTATGTGTGTTAAACATAATTGGGTTATTAAAATGCCTGAAGCTGTTCCAGAA

GGAGTTTCTCGTGGATTTACCGCTTTGG?TTCCGGGATTTGTTGTTGCATTTGTTGTTATCTTTATCAACGGTCTTCTT

GTAGCAATGGGAACAGATATTTTTAAAGTCATTGCAATTCCATTTGGTTTTGTATCCAATCTGACTAATTCGTGGA

TTGGTTTAATGATTATTTATCTATTGACTCAACTACTTTGGATTGTAGGTATCCACGGTGCGAACATTGTTTTTGCA

TTTGTTAGTCCAATTGCTCTTGCTAACATGGCTGAAAATGCTGCTGGCGGGCACTTCGCTGTTGCAGGTGAATTTT

CTAATATGTTTGTAATTGCAGGTGGTTCTGGTGCAACTTTAGGACTATGTTTATATATTGCTTTTGCCTCTAAATCT

GAACAGCTTAAAGCAATAGGACGAGCATCTGTAGTTCCAGCCTTATTTAATATTAATGAACCATTAATTTTTGGAT

TACCTATTATCTATAATCCAGCCTTGGCTATACCATTTATTTTAGCACCAATGGTTACTGCTACTATTTATTACGTA

GCGAATTCTCTAAACTTTATTAAGCCAATTATCGCACAGGTTCCATGGCCAACTCCAGTAGGGATTGGAGCTTTCT

TAGGGACAGCAGATCTTCGAGCTGTATTAGTTGCTCTAGTATGTGCATTTGCAGCATTCCTAGTCTATCTTCCATTC

ATCCGTGTATATGATCAAAAATTGGTGAAAGAAGAGCAAGGTATCTAA

4155.1

ATGAAAAAATTTTATGTAAGTCCAATTTTTCCTATTCTAGTAGGATTGATTGCGTTTGGAGTCTTATCCACTTTCAT

TATTTTTGTTAATAATAATCTGTTGACGGTTTTAATTTTGTTTCTTTTTGTAGGAGGCTATGTTTTTTTATTTAAGAA

ACTGAGAGTGCATTATACAAGGAGTGATGTAGAACAGATACAGTATGTAAACCACCAAGCGGAAGAAAGTTTGAC

AGCTCTATTGGAACAGATGCCTGTAGGTGTTATGAAATTGAATTTATCTTCTGGAGAGGTTGAGTGGTTTAATCCC

TATGCTGAATTGATTTTGACCAAGGAAGATGGTGATTTTGATTTAGAAGCTGTTCAAACGATTATCAAGGCTTCAG

TAGGAAATCCGTCTACTTATGCCAAGCTTGGTGAGAAGCGTTATGCTGTTCATATGGATGCTTCTTCCGGTGTTTT

GTATTTTGTAGATGTATCCAGGGAACAAGCCATAACAGATGAATTGGTAACAAGTAGACCAGTGATTGGGATTGT

CTCTGTGGATAATTATGATGATTTGGAGGATGAAACTTCTGAGTCAGATATTAGTCAAATCAATAGTTTTGTAGCT

AATTTTATATCAGAGTTTTCAGAAAAACACATGATGTTTTCTCGTCGGGTAAGTATGGATCGATTTTATCTATTTAC

TGACTACACGGTGCTTGAGGGCTTGATGAATGATAAATTTTCTGTTATTGATGCTTTCAGAGAAGAGTCGAAACAG

AGACAGTTGCCCTTGACCTTAAGTATGGGATTTTCTTATGGCGATGGAAATCATGATGAGATAGGGAAAGTTGCTT

TGCTCAATTTGAACTTGGCTGAAGTACGTGGTGGCGACCAGGTGGTTGTTAAGGAAAACGACGAAACGAAAAATC

CAGTTTATTTTGGTGGTGGGTCTGCTGCTTCAATCAAGCGTACACGGACTCGTACGCGCGCTATGATGACAGCTAT

TTCAGATAAGATTCGGAGTGTAGATCAGGTTTTTGTAGTCGGTCACAAAAATTTAGACATGGATGCTTTGGGCTCT

GCTGTAGGTATGCAGTTGTTCGCCAGCAATGTGATTGAAAATAGCTATGCTCTTTATGATGAAGAACAAATGTCTC

CAGATATTGAACGAGCTGTTTCATTCATAGAAAAAGAAGGAGTTACGAAGTTGTTGTCTGTTAAGGATGCAATGG

GGATGGTGACCAATCGTTCTTTGTTGATTCTTGTAGACCATTCAAAGACAGCCTTAACATTATCAAAAGAATTTTA

TGATTTATTTACCCAAACCATTGTTATTGACCACCATAGAAGGGATCAGGATTTTCCAGATAATGCGGTTATTACT

TATATCGAAAGTGGTGCAAGTAGTGCCAGTGAGTTGGTAACGGAATTGATTCAGTTCCAGAATTCTAAGAAAAAT

CGTTTGAGTCGTATGCAAGCAAGTGTCTTGATGGCTGGTATGATGTTGGATACTAAAAATTTCACCTCGCGAGTAA

CTAGTCGGACATTTGATGTTGCTAGCTATCTCAGAACGCGCGGAAGTGATAGTATTGCTATCCAGGAAATCGCTGC

GACAGATTTTGAAGAATATCGTGAGGTCAATGAACTTATTTTACAGGGGCGTAAATTAGGTTCAGATGTACTAATA

GCAGAGGCTAAGGACATGAAATGCTATGATACAGTTGTTATTAGTAAGGCAGCAGATGCCATGTTAGCCATGTCA

GGTATTGAAGCGAGTTTTGTTCTTGCGAAGAATACACAAGGATTTATCTCTATCTCAGCTCGAAGTCGTAGTAAAC

TGAATGTACAACGGATTATGGAAGAGTTAGGCGGTGGAGGCCACTTTAATTTGGCAGCAGCTCAAATTAAAGATG

TAACCTTGTCAGAAGCAGGTGAAAAACTGACAGAAATTGTATTAAATGAAATGAAGGAAAAGGAGAAAGAAGAA

TGA

4156.1

ATGAAAGAGAAAAATATGTGGAAAGAATTGTTGAATCGTGCAGGCTGGATTTTGGTCTTTTTACTTGCCGTCCTTT

TATATCAGGTTCCCCTAGTGGTTACCTCTATTTTGACTTTAAAAGAAGTAGCCCTGCTACAGTCAGGGCTGATAGT

TGCTGGCCTTTCAATTGTGGTTCTGGCTCTATTTATTATGGGAGCTCGTAAAACCAAGTTAGCTAGTTTTAATTTTT

CTTTTTTTAGAGCTAAAGATTTGGCACGTTTGGGCTTGAGTTATCTAGTTATTGTCGGGTCAAATATACTTGGTTCC

ATTTTATTGCAACTGTCAAATGAGACGACAACAGCTAACCAGTCTCAGATTAATGATATGGTTCAAAATAGTTCGT

TGATTTCCAGTTTCTTCTTGCTAGCCTTGCTTGCTCCGATTTGTGAGGAAATCTTGTGTCGTGGGATTGTTCCTAAA

AAGATTTTCCGAGGCAAGGAGAACTTGGGATTTGTAGTCGGTACGATTGTGTTTGCTTTATTGCATCAACCAAGTA

ATTTACCTTCTTTATTGATTTATGGAGGTATGTCGACAGTTCTATCTTGGACAGCCTACAAGACCCAACGTTTGGA

AATGTCGATCTTGCTTCACATGATTGTTAATGGGATTGCTTTCTGTTTGTTGGCTCTTGTGGTGATTATGAGTCGGA

CATTAGGAATTTCTGTTTAAATGAAAGAGAAAAATATGTGGAAAGAATTGTTGAATCGTGCAGGCTGGATTTTGGT

CTTTTTACTTGCCGTCCTTTTATATCAGGTTCCCCTAGTGGTTACCTCTATTTTGACTTTAAAAGAAGTAGCCCTGC

TACAGTCAGGGCTGATAGTTGCTGGCCTTTCAATTGTGGTTCTGGCTCTATTTATTATGGGAGCTCGTAAAACCAA

GTTAGCTAGTTTTAATTTTTCTTTTTTTAGAGCTAAAGATTTGGCACGTTTGGGCTTGAGTTATCTAGTTATTGTCG

GGTCAAATATACTTGGTTCCATTTTATTGCAACTGTCAAATGAGACGACAACAGCTAACCAGTCTCAGATTAATGA

TATGGTTCAAAATAGTTCGTTGATTTCCAGTTTCTTCTTGCTAGCCTTGCTTGCTCCGATTTGTGAGGAAATCTTGT

GTCGTGGGATTGTTCCTAAAAAGATTTTCCGAGGCAAGGAGAACTTGGGATTTGTAGTCGGTACGATTGTGTTTGC

TTTATTGCATCAACCAAGTAATTTACCTTCTTTATTGATTTATGGAGGTATGTCGACAGTTCTATCTTGGACAGCCT

ACAAGACCCAACGTTTGGAAATGTCGATCTTGCTTCACATGATTGTTAATGGGATTGCTTTCTGTTTGTTGGCTCTT

GTGGTGATTATGAGTCGGACATTAGGAATTTCTGTTTAA

4156.4

ATGGATACACAAAAGATTGAAGCGGCTGTAAAAATGATTATCGAGGCTGTAGGAGAGGACGCTAATCGCGAGGGC

TTGCAGGAAACACCTGCTCGTGTAGCCCGTATGTATCAAGAGATTTTTTCAGGTCTTGGTCAAACAGCAGAGGAAC

ATTTGTCAAAATCCTTTGAAATTATTGACGATAATATGGTGGTAGAAAAGGATATCTTTTTCCATACCATGTGTGA

ACACCACTTCTTGCCATTTTATGGTAGAGCGCACATTGCCTACATTCCAGATGGTCGTGTGGCAGGCTTGTCTAAG

CTAGCCCGTACGGTTGAAGTTTATTCGAAAAAACCACAAATTCAAGAACGTTTGAATATCGAAGTGGCCGATGCC

TTGATGGACTATCTAGGTGCTAAAGGAGCCTTTGTTGTCATTGAGGCGGAACATATGTGTATGAGTATGCGTGGTG

TTAGAAAACCAGGCACTGCAACCTTGACGACAGTAGCTCGTGGTCTATTTGAAACAGATAAGGATCTCCGTGACC

AAGCTTATCGTTTAATGGGGCTATAA

4157.2

ATGAAAGACTTGTTTTTAAAGAGAAAGCAGGCCTTTCGTAAGGAGTGTCTTGGTTATCTGCGCTATGTGCTCAATG

ACCACTTTGTCTTGTTCCTGCTTGTCCTGTTGGGCTTTCTAGCCTACCAGTACAGTCAACTCTTACAACATTTTCCT

GAAAATCATTGGCCTATCCTTTTGTTTGTAGGAATTACGTCTGTTTTACTTTTACTTTGGGGAGGAACTGCCACCTA

TATGGAGGCTCCAGACAAGCTCTTTCTCTTAGTTGGAGAAGAGGAAATTAAGCTCCATCTCAAGCGTCAAACTGG

CATTTCCCTAGTCTTTTGGCTCTTTGTACAGACCCTTTTCTTGCTGTTATTTGCGCCTTTATTTTTAGCAATGGGTTA

TGGCTTGCCAGTTTTTCTGCTCTATGTGCTTTTATTGGGGGTAGGAAAATATTTCCACTTTTGTCAAAAGGCCAGCA

AATTTTTCACTGAAACTGGACTGGACTGGGACTATGTTATTTCTCAAGAAAGCAAGCGTAAGCAAGTCTTGCTTCG

TTTCTTTGCCCTCTTTACGCAGGTCAAGGGAATTTCAAACAGCGTTAAGCGTCGTGCCTATCTGGACTTTATTTTAA

AGGCTGTTCAGAAGGTGCCTGGGAAGATTTGGCAAAATCTCTATCTGCGTTCTTATCTGCGAAATGGCGACCTCTT

TGCTCTCAGTCTTCGTCTTCTCTTGCTTTCCTTGCTGGCGCAGGTTTTTATCGAGCAAGCTTGGATTGCGACAGCAG

TGGTAGTTCTCTTTAACTACCTCTTGCTCTTCCAGTTGCTGGCCCTCTATCATGCCTTTGACTACCAGTATTTGACC

CAACTCTTTCCGCTGGACAAGGGGCAAAAGGAAAAAGGCTTACAGGAGGTAGTTCGAGGATTGACCAGTTTTGTT

TTACTTGTGGAATTAGTTGTTGGGTTGATTACCTTCCAAGAAAAACTAGCCCTTCTAGCCTTACTAGGAGCTGGTT

TGGTTTTACTAGTCTTGTATTTGCCTTATCAGGTAAAACGTCAGATGCAGGACTAA

4158.1

ATGAGAAAATCAATAGTATTAGCGGCAGATAATGCCTATCTTATTCCTTTAGAGACGACTATAAAGTCTGTATTGT

ATCACAATAGAGATGTTGATTTTTATATTCTCAACAGTGATATAGCTCCTGAATGGTTTAAATTATTGGGGAGAAA

AATGGAAGTTGTGAATTCTACAATTCGCAGTGTACACATTGATAAAGAACTTTTTGAAAGCTATAAAACAGGACCT

CATATAAATTATGCTTCTTACTTTAGATTTTTTGCGACAGAAGTGGTTGAATCTGATAGGGTATTGTATCTGGATTC

CGATATCATTGTAACTGGGGAACTAGCTACTTTGTTTGAGATAGATCTCAAAGGATATTCAATTGGTGCTGTTGAT

GATGTCTATGCCTATGAAGGACGAAAATCTGGATTTAATACTGGTATGTTACTAATGGATGTTGCAAAGTGGAAAG

AACATTCTATTGTCAATAGTTTATTGGAATTAGCGGCCGAGCAGAATCAAGTTGTTCATCTTGGGGATCAGAGTAT

TTTAAATATTTATTTTGAGGATAATTGGCTAGCCTTAGATAAAACATATAATTATATGGTGGGTATTGATATTTATC

ACCTTGCTCAAGAATGTGAACGTCTAGATGACAATCCACCTACAATTGTTCACTATGCTAGTCATGATAAACCTTG

GAATACATATAGTATATCTAGACTACGTGAATTATGGTGGGTTTATAGAGATTTGGATTGGTCAGAGATTGCTTTT

CAACGTTCCGATTTAAATTATTTTGAAAGAAGCAATCAGTCTAAAAAACAAGTGATGCTTGTGACATGGAGTGCA

GATATAAAACATTTAGAGTATTTAGTACAACGGTTACCTGATTGGCATTTTCATTTGG?CTGCACCGTGTGATTGTTC

TGAGGAGCTGACCTCTCTATCACAGTATACGAATGTAACAGTATATCAAAATGTATTACATAGTAGAATTGATTGG

CTATTGGACGATTCTATAGTTTATTTAGATATTAATACAGGTGGAGAGGTTTTTAATGTAGTTACAAGGGCACAAG

AAAGTGGCAAGAAAATCTTCGCTTTTGATATCACACGTAAAAATATGGATGATGGACTCTATGACGGTATTTTTTC

TGTGGAGAGACCAGATGATTTAGTGGATAGAATGAAGAATATAGAGATAGAGTAA

4158.2

ATGACTAAGATTTATTCGTCAATAGCAGTAAAAAAAGGACTATTTACCTCATTTCTACTGTTTATCTATGTATTGG

GAAGTCGTATTATTCTCCCTTTTGTTGACCTAAATACTAAAGATTTTTTAGGAGGTTCAACAGCCTATCTAGCCTTC

TCAGCCGCCCTAACAGGTGGGAATCTAAGAAGTTTATCAATTTTTTCTGTTGGATTATCCCCTTGGATGTCCGCCA

TGATTTTATGGCAGATGTTTTCTTTTTCTAAACGGTTGGGTTTAACATCTACGTCTATAGAAATACAAGATCGCCGT

AAAATGTACCTGACCTTGCTAATTGCTGTGATTCAATCCTTGGCAGTTAGCTTGAGACTGCCAGTACAATCCTCCT

ATTCTGCAATATTGGTTGTTCTAATGAATACAATATTGCTGATAGCAGGAACATTTTTTCTTGTTTGGTTGTCAGAT

TTAAATGCGAGTATGGGGATTGGAGGTTCTATTGTAATCCTCCTATCCAGTATGGTTTTAAATATTCCTCAGGATG

TTTTGGAAACATTTCAGACAGTACACATTCCAACAGGGATTATTGTGTTACTTGCTTTATTAACCCTTGTCTTTTCT

TATTTACTTGCCCTTATGTATCGAGCTCGCTATTTGGTTCCTGTTAATAAAATTGGCTTACACAATCGATTTAAACG

CTATTCTTATCTCGAAATCATGTTGAATCCTGCAGGTGGGATGCCTTATATGTATGTGATGAGTTTTCTTAGTGTAC

CAGCTTATTTGTTCATCTTGTTGGGATTTATTTTCCCTAATCATTCAGGGTTAGCGGCTTTATCAAAGGAATTTATG

GTTGGAAAGCCTTTGTGGGTCTATGTTTATATTTCGGTCTTATTTTTATTTAGTATCATTTTTGCTTTTGTTACGATG

AATGGAGAAGAGATTGCAGACCGTATGAAAAAATCTGGAGAATACATTTATGGTATTTATCCAGGTGCGGATACT

AGTCGAGTTATTAATCGATTGGTCCTTCGTTTCTCAGTCATAGGTGGTCTCTTTAATGTGATTATGGCAGGTGGTCC

CATGCTTTTTGTTTTGTTTGATGAAAAGTTATTACGATTGGCAATGATTCCAGGCTTATTTATGATGTTCGGGGGCA

TGATTTTTACGATTAGAGACGAGGTCAAGGCTTTAAGGCTAAATGAGACCTATAGACCTTTGATTTAG

4158.3

ATGTCCTCTCTTTCGGATCAAGAATTAGTAGCTAAAACAGTAGAGTTTCGTCAGCGTCTTTCCGAGGGAGAAAGTC

TAGACGATATTTTGGTTGAAGCTTTTGCTGTGGTGCGTGAAGCAGATAAGCGGATTTTAGGGATGTTTCCTTATGA

TGTTCAAGTCATGGGAGCTATTGTCATGCACTATGGAAATGTTGCTGAGATGAATACGGGGGAAGGTAAGACCTT

GACAGCTACCATGCCTGTCTATTTGAACGCTTTTTCAGGAGAAGGAGTGATGGTTGTGACTCCTAATGAGTATTTA

TCAAAGCGTGATGCCGAGGAAATGGGTCAAGTTTATCGTTTTCTAGGATTGACCATTGGTGTACCATTTACGGAAG

ATCCAAAGAAGGAGATGAAAGCTGAAGAAAAGAAGCTTATCTATGCTTCGGATATCATCTACACAACCAATAGTA

ATTTAGGTTTTGATTATCTAAATGATAACCTAGCCTCGAATGAAGAAGGTAAGTTTTTACGACCGTTTAACTATGT

GATTATTGATGAAATTGATGATATCTTGCTTGATAGTGCACAAACTCCTCTGATTATTGCGGGTTCTCCCCGTGTTC

AGTCTAATTACTATGCGATCATTGATACACTTGTAACAACCTTGGTCGAAGGAGAGGATTATATCTTTAAAGAGGA

GAAAGAGGAGGTTTGGCTCACTACTAAGGGGGCCAAGTCTGCTGAGAATTTCCTAGGGATTGATAATTTATACAA

GGAAGAGCATGCGTCTTTTGCTCGTCATTTGGTTTATGCGATTCGAGCTCATAAGCTCTTTACTAAAGATAAGGAC

TATATCATTCGTGGAAATGAGATGGTACTGGTTGATAAGGGAACAGGGCGTCTAATGGAAATGACTAAACTTCAA

GGAGGTCTCCATCAGGCTATTGAAGCCAAGGAACATGTCAAATTATCTCCTGAGACGCGGGCTATGGCCTCGATC

ACCTATCAGAGTCTTTTTAAGATGTTTAATAAGATATCTGGTATGACAGGGACAGGTAAGGTCGCGGAAAAAGAG

TTTATTGAAACTTACAATATGTCTGTAGTACGCATTCCAACCAATCGTCCGAGACAACGGA

TTGACTATCCAGATAATCTATATATCACTTTACCTGAAAAAGTGTATGCATCCTTGGAGTACATCAAGCAATACCA

TGCTAAGGGAAATCCTTTACTCGTTTTTGTAGGCTCAGTTGAAATGTCTCAACTCTATTCGTCTCTCTTGTTTCGTG

AAGGGATTGCCCATAATGTCCTAAATGCTAATAATGCGGCGCGTGAGGCTCAGATTATCTCCGAGTCAGGTCAGA

TGGGGGCTGTGACAGTGGCTACCTCTATGGCAGGACGTGGTACGGATATCAAGCTTGGTAAAGGAGTCGCAGAGC

TTGGGGGCTTGATTGTTATTGGGACTGAGCGGATGGAAAGTCAGCGGATCGACCTACAAATTCGTGGCCGTTCTGG

TCGTCAGGGAGATCCTGGTATGAGTAAATTTTTTGTATCCTTAGAGGATGATGTTATCAAGAAATTTGGTCCATCT

TGGGTGCATAAAAAGTACAAAGACTATCAGGTTCAAGATATGACTCAACCGGAAGTATTGAAAGGTCGTAAATAC

CGGAAACTAGTCGAAAAGGCTCAGCATGCCAGTGATAGTGCTGGACGTTCAGCACGTCGTCAGACTCTGGAGTAT

GCTGAAAGTATGAATATACAACGGGATATAGTCTATAAAGAGAGAAATCGTCTAATAGATGGTTCTCGTGACTTA

GAGGATGTTGTTGTGGATATCATTGAGAGATATACAGAAGAGGTAGCGGCTGATCACTATGCTAGTCGTGAATTAT

TGTTTCACTTTATTGTGACCAATATTAGTTTTCATGTTAAAGAGGTTCCAGATTATATAGATGTAACTGACAAAACT

GCAGTTCGTAGCTTTATGAAGCAGGTGATTGATAAAGAACTTTCTGAAAAGAAAGAATTACTTAATCAACATGACT

TATATGAACAGTTTTTACGACTTTCACTGCTTAAAGCCATTGATGACAACTGGGTAGAGCAGGTAGACTATCTACA

ACAGCTATCCATGGCTATCGGTGGTCAATCTGCTAGTCAGAAAAATCCAATCGTAGAGTACTATCAAGAAGCCTA

CGCGGGCTTTGAAGCTATGAAAGAACAGATTCATGCGGATATGGTGCGTAATCTCCTGATGGGGCTGGTTGAGGT

CACTCCAAAAGGTGAAATCGTGACTCATTTTCCATAA

4158.4

ATGATAGGGACTTTCGCCGCTGCTCTTGTAGCTGTACTAGCAAATTTCATCGTCCCTATTGAAATTACCCCAAATA

GTGCCAATACTGAAATTGCACCACCAGATGGGATTGGGCAGGTTCTCAGCAACCTCTTGCTCAAACTGGTTGACA

ACCCAGTCAACGCCCTGCTTACTGCTAACTATATTAGAATCTTATCTTGGGCAGTCATTTTTGGAATCGCTATGAG

AGAAGCCAGTAAAAATAGTCAAGAATTGCTAAAAACTATCGCTGACGTGACTTCTAAAATTGTCGAATGGATCAT

CAATCTGGCTCCATTTGGAATCCTTGGTCTTGTTTTTAAAACCATTTCTGACAAGGGAGTCGGAAGCCTTGCCAAC

TACGGTATTTTATTGGTTCTATTAGTAACGACTATGCTTTTTGTTGCCCCTGTGGTCAACCCTTTGATTGCCTTCTTC

TTTATGAGACGCAATCCTTACCCTCTAGTTTGGAACTGCCTCCGTGTCAGCGGTGTGACAGCCTTTTTCACTCGTA

GTTCTGCGACTAACATTCCTGTCAACATGAAACTCTGCCATGACCTTGGACTCAACCCAGATACCTATTCTGTTTC

TATCCCACTCGGTTCTACTATCAATATGGCTGGAGTAGCGATTACCATTAACCTTTTGACCCTTGCTGCAGTTAAC

ACTCTTGGAATTCCTGTTGACTTTGCCACAGCCTTTGTCCTCAGTGTGGTAGCAGCTATCTCATCCTGTGATGCTTC

AGGTATTGCCGGAGGTTCCCTCCTTCTTATCCCAGTTGCTTGTAGCCTTTTCGGTATTTCTAACGATATTGCCATAC

AAATTGTTGGGGTTGGTTTTGTGATTGGTGTCATCCAAGACTCATGTGAAACAGCCCTTAACTCTTCTACAGATGT

CCTCTTTACCGCCGTTGCCGAATACGCAGCAACCCGTAAAAAATAA

4158.5

ATGTCTATTAGCCAACGTACGACCAAGCTCATCTTAGCTACCTGTCTTGCCTGCCTGCTTGCTTATTTTCTCAATCT

TTCGTCAGCAGTTTCGGCTGGAATTATCGCTCTCTTGAGCCTATCTGATACGCGTAGAAGTACTTTAAAACTGGCT

CGCAATCGTCTTTTTTCTATGCTTCTAGCTCTGGCTATCGGTGTTCTAGCTTTTCACTTGAGCGGATTTCATATCTG

GAGTCTCGGCCTCTATCTGGCCTTCTACGTTCCTTTAGCCTACAAGATGGGCTGGGAAATTGGCATCACACCAAGC

ACTGTTTTGGTTAGCCATCTCTTGGTTCAAGAGTCAACCTCTCCAGACCTTCTAGTCAATGAATTCCTTCTCTTTGC

TATTGGTACAGGATTTGCCTTGCTTGTTAATCTCTATATGCCTTCACGAGAAGAGGAAATCCAGCACTACCACACG

CTGGTGGAAGAAAAGTTAAAAGATATCCTCCAGCGCTTCAAATACTATTTATCCAGAGGAGACGGACGCAACCGA

GCACAGCTGGTAGCAGAATTAGACACGCTTTTGAAAGAAGCCCTCAGACTGGTCTATTTGGATCACTCTGACCACC

TCTTTCACCAGACAGACTACCATATCCACTACTTTGAGATGAGACAGCGACAAAGTCGTATCCTGAGAAACATGG

CCCAACAGATTAACACTTGTCACCTTGCCGCCAGTGAAAGCCTGATCTTAGCGCAACTCTTTTCAAAAATTGCAGG

TCAACTGAGCCAGACCAATCCTGCTTCTGATTTGCTAGATGAAATTGAACGTTATCTGGAAGTCTTCCGGAACCGC

AGTCTGCCCAAGACAAGAGAAGAATTTGAAACCCGCGCCACCCTTCTTCAACTCCTACGTGAAGCCAAAACCTTC

ATCCAAGTAAAAGTTGATTTTTACCAAAAATATAGACAGTAA

4158.6

ATGGAAATCATGTCGCTTGCGATTGCTGTTTTTGCCGTCATCATTGGTTTAGTCATTGGATATGTCAGCATCTCAGC

TAAGATGAAATCATCTCAGGAAGCTGCAGAGTTGATGCTTTTAAATGCTGAACAAGAAGCAACTAATTTACGTGG

ACAAGCTGAGCGTGAAGCGGATTTACTTGTTAATGAAGCCAAACGTGAAAGCAAGTCTCTTAAAAAAGAAGCACT

ATTGGAGGCCAAAGAAGAAGCCAGAAAATACCGTGAAGAAGTGGACGCTGAATTCAAATCAGAACGTCAAGAAC

TCAAACAAATCGAAAGTCGTTTGACAGAGAGAGCTACTAGCCTTGACCGTAAGGACGACAATTTGACGAGTAAAG

AACAAACACTTGAACAAAAAGAACAAAGTATTTCTGATAGAGCGAAAAACCTTGATGCGCGTGAAGAGCAATTAG

AGGAAGTCGAAAGACAAAAAGAAGCAGAACTAGAGCGTATTGGTGCGCTGTCTCAGGCAGAAGCACGAGATATT

ATCTTGGCTCAGACAGAGGAAAACTTGACCAGGGAGATTGCCAGTCGCATTCGCGAAGCTGAGCAAGAGGTCAAG

GAACGTTCTGACAAAATGGCCAAGGACATCTTGGTTCAAGCTATGCAACGTATCGCTGGTGAATATGTAGCGGAG

TCAACAAACTCAACAGTTCATCTGCCAGACGATACTATGAAGGGACGCATTATTGGTCGTGAAGGTCGTAACATT

CGTACCTTTGAAAGTTTGACAGGGGTCGATGTGATTATCGACGATACACCAGAAGTGGTGACCTTGTCAGGATTTG

ATCCGATTCGTCGTGAGATTGCCCGTATGACTATGGAAATGTTGCTCAAAGATGGTCGTATACATCCAGCTCGTAT

CGAAGAGTTGGTTGAGAAAAACCGTCAAGAGATTGACAATAAGATTCGTGAATACGGTGAGGCTGCTGCCTATGA

AATTGGTGCGCCAAACCTTCATCCAGACTTGATGAAGATTATGGGACGTTTGCAGTTCCGTACTTCATATGGACAA

AATGTTTTGCGCCATTCGATTGAGGTTGCTAAGTTGGCTGGTATCATGGCGAGCGAACTTGGTGAAAATGCGGCTC

TTGCCCGTCGTGCTGGATTCCTTCACGATATCGGGAAAGCCATTGACCATGAGGTTGAAGGTAGCCACGTTGAAAT

CGGTATGGAATTGGCCCGTAAGTACAAGGAACCCCCAGTTGTGGTGAATACGATTGCTAGTCACCACGGAGATGT

TGAAGCTGAGAGCGTGATAGCAGTTATCGTCGCTGCAGCAGATGCCTTGAGCGCAGCCCGTCCAGGTGCTCGTAG

TGAGTCTCTTGAAAGCTACATCAAGCGTCTCCATGATTTGGAAGAAATTGCTAACGGCTTTGAAGGAGTGCAAACT

AGCTTTGCCCTTCAAGCAGGACGTGAAATTCGTATCATGGTCAATCCAGGAAAAATCAAGGACGACAAAGTCACA

ATCTTGGCTCACAAAGTTCGTAAGAAAATTGAAAACAATCTCGATTATCCAGGAAATATCAAGGTAACCGTGATT

CGCGAGCTTCGTGCAGTAGATTATGCTAAATAA

4158.7

ATGATGTTAAAACCCTCTATTGATACCTTGCTCGACAAGGTTCCTTCAAAATATTCACTCGTAATCTTGGAAGCAA

AACGTGCCCACGAATTGGAAGCAGGTGCCCCAGCAACTCAAGGTTTCAAGTCTGAAAAATCAACTCTTCGCGCTT

TAGAAGAAATCGAATCAGGAAACGTTACAATTCACCCAGATCCAGAAGGAAAACGTGAAGCAGTGCGTCGCCGTA

TCGAAGAAGAAAAACGCCGCAAAGAAGAAGAAGAAAAGAAAATCAAAGAGCAAATTGCTAAAGAAAAAGAAGA

TGGTGAAAAAATTTAA

4161.1

ATGTCAGCATATCAATTACCGACCGTATGGCAGGATGAAGCTAGTAATCAAGGAGCTTTACGGGGCTAAACAGA

CCAACAGCAGGTGCCCGTTTCGAACAAAACTTGCCAAAAGGAGAACAAGCTTTTCAGCTTTATTCACTGGGAACA

CCAAATGGTGTGAAGGTTACTATCTTATTGGAAGAATTACTAGAAGCTGGTTTTAAGGAAGCGGCTTACGACTTGT

ATAAGATTGCTATCATGGATGGGGATCAATTCGGATCAGACTTTGTGAAGCTCAATCCAAATTCCAAGATTCCAGC

CTTATTGGACCAGTCAGGTACTGAAAACGTAAGAGTCTTTGAGTCTGCTCATATTCTTCTTTACCTTGCTGAGAAA

TTTGGAGCCTTTTTACCAAGTAATCCTGTGGAAAAGGTAGAAGTTTTGAATTGGCTATTCTGGCAAGCAGGTGCAG

CACCTTTTCTAGGTGGGGGATTTGGACATTTCTTCAATTATGCTCCTGAAAAATTGGAATATCCTATTAACCGTTTT

ACGATGGAAGTGAAACGCCAGTTGGATTTATTGGATAAGGAATTGGCTCAGAAACCTTATATTGCAGGCAATGAC

TATACGATTGCAGATATTGCTATCTGGTCTTGGTATGGACAGTTAGTTCAAGGAAATCTTTACCAAGGTTCTGCAA

AATTCTTGGATGCCTCAAGTTATCAAAATCTAGTAAAATGGGCAGAAAAAATTGCCAATCGTCCAGCTGTTAAGC

GTGGCTTGGAAGTAACTTATACAGAAATTAAATAG

4161.2

TTGGCAAGCTTGATCACTTCTATCATCATGTTCTATGTCGGTTTCGATGTTCTAAGAGATACCATTCAAAAGATTCT

CAGTCGGGAAGAAACGGTCATTGATCCTCTTGGTGCAACTCTAGGAATCATTTCTGCAGCGATTATGTTTGTGGTC

TATCTCTACAATACTCGCCTCAGTAAGAAATCCAACTCCAATGCGCTGAAGGCAGCTGCTAAGGACAATCTTTCTG

ACGCTGTTACCTCACTTGGAACCGCCATTGCCATCCTAGCTAGTAGTTTCAATTATCCGATTGTGGATAAACTGGT

TGCTATCATCATCACTTTCTTTATCTTGAAGACTGCCTATGATATCTTCATCGAGTCTTCCTTTAGTCTTTCAGATG

GCTTTGACGACCGCCTGCTCGAGGACTACCAAAAGGCTATCATGGAAATTCCCAAAATCAGCAAGGTCAAATCGC

AAAGAGGTCGCACCTACGGTAGCAACATCTACCTGGATATTACACTAGAGATGAATCCTGACTTGTCTGTTTTTGA

AAGCCATGAAATCGCGGATCAGGTCGAGTCTATGCTGGAGGAGCGTTTTGGCGTCTTTGATACCGATGTCCATATC

GAACCAGCACCTATCCCTGAGGATGAAATTTTAGACAATGTCTATAAAAAATTGCTTATGCGTGAACAATTGATTG

ACCAAGGAAACCAACTAGAAGAACTCTTGACTGATGATTTTGTCTATATTCGCCAAGATGGAGAGCAGATGGATA

AAGAGGCTTATAAGACCAAAAAAGAGTTAAATTCTGCTATCAAGGACATTCAAATTACTTCCATCAGTCAAAAAA

CCAAACTCATCTGCTATGAGTTAGATGGTATCATCCATACCAGTATCTGGCGTCGCCACGAAACCTGGCAAAATAT

CTTTCATCAAGAAACCAAAAAAGAATAG

4162.1

ATGACAATTAAACTAGTAGCAACGGATATGGACGGAACCTTCCTAGATGGGAATGGACGCTTTGATATGGATCGT

CTCAAGTCTCTCTTGGTTTCCTACAAGGAAAAAGGGATTTACTTTGCGGTAGCTTCGGGTCGGGGATTTCTGTCTC

TAGAAAAATTATTTGCTGGTGTTCGTGATGACATTATTTTCATCGCGGAAAATGGCAGTTTGGTAGAGTATCAAGG

TCAGGACTTGTATGAAGCGACTATGTCTCGTGACTTTTATCTGGCAACTTTTGAAAAGCTGAAAACTTCACCTTAT

GTAGATATCAATAAACTGCTCTTGACGGGTAAGAAGGGTTCATATGTTCTAGATACGGTTGATGAGACCTATTTGA

AAGTGAGTCAGCACTATAATGAAAATATCCAAAAAGTAGCGAGTTTGGAAGATATCACAGATGACATTTTCAAAT

TTACAACCAACTTCACAGAAGAAACGCTGGAAGATGGGGAGGCTTGGGTAAACGAAAACGTTCCTGGTGTTAAGG

CCATGACAACTGGCTTTGAATCCATTGATATTGTTCTGGACTATGTCGATAAGGGAGTGGCCATTGTTGAATTAGT

TAAAAAACTTGGTATCACAATGGATCAGGTCATGGCTTTTGGAGACAATCTTAATGACTTACATATGATGCAGGTT

GTGGGACATCCTGTAGCTCCTGAAAATGCACGACCTGAAATTTTAGAATTAGCAAAGACTGTGATTGGTCACCATA

AGGAACGGTCGGTTATAGCTTATATGGAGGGCTTATAA

4162.2

ATGGCAGATATAAAATTGATTGCATTGGACTTGGACGGGACCTTGCTGACTACTGATAAAAGGCTGACGGATCGT

ACCAAGGAAACCTTGCAAGCTGCGCGTGATCGTGGTATCAAGGTCGTATTGACAACTGGTCGTCCCTTAAAAGCC

ATGGATTTCTTTCTCCATGAGTTAGGGACTGACGGTCAGGAAGATGAGTATACCATTACTTTTAATGGTGGATTAG

TTCAGAAAAATACAGGAGAAATCCTTGATAAAACAGTCTTTTCATATGATGATGTGGCACGTTTGTATGAAGAAAC

AGAGAAATTATCACTGCCTCTTGATGCCATCTCAGAAGGAACAGTTTATCAAATCCAATCGGACCAAGAAAGTCT

TTATGCCAAATTCAATCCAGCTTTGACCTTTGTTCCAGTGGACTTTGAAGACTTATCTAGTCAAATGACCTACAAC

AAATGCGTGACTGCCTTTGCTCAAGAACCCTTGGATGCAGCCATTCAGAAGATTTCTCCAGAATTGTTTGACCAAT

ATGAAATCTTTAAATCACGTGAAATGTTGCTAGAATGGTCACCAAAGAATGTTCATAAAGCAACAGGTTTGGCAA

AACTAATCAGCCATCTTGGAATCGACCAAAGTCAAGTGATGGCTTGTGGTGACGAGGCCAATGACCTCTCTATGA

TTGAATGGGCAGGTCTTGGTGTTGCTATGCAAAACGCTGTTCCTGAAGTAAAGGCAGCCGCAAATGTAGTGACGC

CGATGACCAACGATGAGGAAGCTGTCGCCTGGGCTATCGAAGAATATGTGCTAAAGGAGAACTAA

4164.2

ATGGAAAGTTTACTTATTCTATTATTAATTGCCAATCTAGCTGGTCTCTTTCTGATTTGGCAAAGGCAGGATAGGC

AGGAGAAACACTTAAGTAAGAGCTTGGAGGATCAGGCAGATCATTTGTCAGACCAGTTGGATTACCGCTTTGACC

AAGCCAGACAAGCCAGCCAGTTAGACCAAAAAGATTTGGAAGTGGTTGTCAGCGACCGTTTGCAAGAAGTGCGGA

TTGAATTGCACCAAGGTCTGACCCAAGTCCGTCAAGAAATGACAGATAATCTCCTCCAAACTAGAGACAAGACAG

ACCAACGTCTCCAAGCCTTGCAGGAATCAAATGAGCAACGTTTGGAACAAATGCGCCAGACGGTCGAGGAAAAAC

TAGAAAAGACCTTGCAGACACGCTTACAGGCTTCCTTTGAGACAGTTTCTAAACAACTGGAGTCTGTCAATCGTGG

CCTTGGAGAAATGCAGACAGTTGCCCGTGATGTCGGAGCTCTTAACAAGGTTCTCTCTGGAACCAAGACGCGAGG

GATTCTGGGAGAATTGCAACTGGGGCAAATTATTGAAGACATCATGACACCTGCCCAGTACGAACGAGAATACGC

AACGGTTGAAAACTCTAGTGAACGAGTGGAGTATGCCATCAAGTTACCCGGACAAGGCGACCAAGAATACGTCTA

TCTGCCAATTGACTCTAAGTTTCCACTGGCAGATTATTACCGCTTGGAAGAAGCCTATGAGACAGGTGACAAGGAT

GAGATTGAACGCTGTCGTAAGTCACTCCTAGCAAGCGTCAAGCGCTTTGCTAGGGATATTAGGAACAAGTACATA

GCACCACCTCGGACGACCAATTTTGGAGTTTTGTTTGTTCCGACAGAAGGTCTCTACTCAGAAATCGTCCGCAATC

CGGTCTTCTTTGATGATTTGAGACGGGAAGAACAGATTATTGTTGCAGGACCAAGTACCCTATCAGCCCTTCTTAA

CTCCCTATCAGTTGGTTTCAAGACCCTTAATATCCAAAAGAGTGCCGACCATATCAGCAAGACTCTTGCCAGTGTC

AAGACCGAGTTTGGCAAGTTTGGTGGTATTCTGGTCAAGGCACAAAAACATCTCCAACATGCCTCTGGCAATATTG

ATGAATTATTAAACCGTCGTACCATAGCTATCGAGCGGACGCTCCGTCACATTGAGTTGTCAGAAGGTGAGCCTGC

GGTTGATCTACTCCATTTTCAAGAAAATGAGGAAGAATATGAAGATTAG

4164.3

ATGAAGATTAGTCACATGAAAAAAGATGAGTTATTTGAAGGCTTTTACCTAATCAAATCAGCTGACCTGAGGCAA

ACTCGAGCTGGGAAAAACTACCTAGCCTTTACCTTCCAAGATGATAGTGGCGAGATTGATGGGAAGCTCTGGGAT

GCCCAACCTCATAACATTGAGGCCTTTACCGCAGGTAAGGTTGTCCACATGAAAGGACGCCGAGAAGTTTATAAC

AATACCCCTCAAGTCAATCAAATTACTCTCCGCCTGCCTCAAGCTGGTGAACCCAATGACCCAGCTGATTTCAAGG

TCAAGTCACCAGTTGATGTCAAGGAAATTCGTGACTACATGTCGCAAATGATTTTCAAAATTGAAAATCCTGTCTG

GCAACGGATTGTCCGAAATCTCTACACCAAGTATGATAAGGAATTCTACTCCTATCCAGCTGCCAAGACCAACCA

CCATGCCTTTGAAACGGGCTTGGCCTATCATACGGCGACCATGGTGCGTTTGGCAGACGCTATTAGCGAAGTTTAT

CCTCAGCTCAATAAGAGCCTGCTCTATGCGGGGATTATGTTGCATGACTTAGCTAAGGTCATCGAGTTGACGGGGC

CAGACCAGACAGAGTACACAGTGCGAGGTAATCTTCTTGGACATATCGCTCTCATTGATAGCGAAATTACCAAGA

CAGTTATGGAACTCGGCATCGATGATACCAAGGAAGAAGTCGTTTTGCTTCGTCATGTCATCCTCAGTCACCACGG

CTTGCTTGAGTATGGAAGCCCAGTCCGTCCACGCATTATGGAAGCAGAGATTATCCATATGATTGACAATCTGGAT

GCAAGCATGATGATGATGTCAACAGCTCTTGCTTTGGTGGATAAAGGAGAGATGACCAATAAAATCTTCGCTATG

GATAATCGTTCCTTCTATAAACCAGATTTAGATTAA

4166.2

ATGAGTGAAAAAGCTAAAAAAGGGTTTAAGATGCCTTCATCTTACACCGTATTATTGATAATCATTGCTATTATGG

CAGTGCTAACTTGGTTTATCCCTGCGGGGGCCTTTATAGAAGGTATTTACGAGACTCAGCCTCAAAATCCACAAGG

GATTTGGGATGTCCTCATGGCACCGATTCGGGCTATGCTAGGTACTCATCCAGAGGAAGGTTCGCTCATTAAAGAA

ACGAGCGCAGCGATTGATGTAGCCTTCTTCATCCTTATGGTTGGTGGTTTCCTTGGCATTGTCAACAAAACTGGTG

CTCTTGACGTAGGGATTGCCTCTATCGTGAAGAAGTATAAGGGCCGCGAAAAAATGTTAATTTTGGTACTGATGCC

TTTGTTTGCCCTCGGTGGTACAACTTATGGTATGGGTGAAGAAACAATGGCCTTCTATCCACTCCTTGTGCCAGTT

ATGATGGCCGTTGGTTTTGATAGCCTGACTGGTGTTGCAATTATTTTGCTCGGTTCTCAAATCGGCTGTTTGGCATC

TACTCTGAATCCATTTGCGACAGGTATTGCTTCAGCGACTGCGGGAGTTGGTACAGGGGACGGTATCGTACTTCGT

CTGATCTTCTGGGTTACCTTGACTGCTCTTAGTACTTGGTTTGTTTACCGTTATGCGGATAAGATTCAAAAAGATCC

GACTAAGTCACTGGTTTATAGTACTCGCAAAGAAGATTTGAAACACTTTAACGTAGAAGAATCTTCATCTGTAGAA

TCTACACTTAGCAGCAAACAAAAATCAGTTCTCTTCTTATTTGTGTTGACATTCATCTTGATGGTATTGAGCTTCAT

TCCATGGACAGACCTTGGCGTTACCATTTTTGATGACTTTAATACTTGGTTGACTGGTCTTCCAGTTATTGGTAATA

TTGTCGGTTCATCTACTTCTGCACTAGGTACTTGGTACTTCCCAGAAGGCGCAATGCTCTTTGCCTTTATGGGTATC

CTGATTGGTGTTATTTATGGTCTTAAAGAAGATAAGATTATCTCTTCCTTCATGAATGGTGCTGCTGACTTGCTCAG

TGTTGCCTTGATCGTAGCGATTGCTCGTGGTATTCAAGTTATCATGAACGACGGTATGATTACCGATACAATCCTC

AACTGGGGTAAAGAAGGCTTGAGCGGTCTATCTTCACAAGTCTTTATCGTTGTAACTTATATCTTCTATCTACCTAT

GTCATTCTTGATCCCATCTTCATCTGGTCTTGCCAGCGCAACTATGGGTATCATGGC

TCCACTTGGAGAATTTGTAAATGTCCGTCCTAGCTTGATTATCACTGCTTACCAATCTGCTTCAGGTGTCTTGAACT

TGATTGCACCAACATCTGGTATTGTGATGGGAGCTCTTGCACTTGGACGTATCAACATTGGTACTTGGTGGAAATT

CATGGGCAAACTCGTAGTCGCTATTATTGTAGTGACCATCGCCCTTCTTCTCCTTGGAACCTTCCTTCCATTCCTAT

AA

4166.3

ATGAAAATAGATATAACAAATCAAGTTAAAGATGAATTTCTTATATCATTAAAAACCTTGATTTCCTATCCTTCAG

TACTCAATGAAGGAGAAAATGGAACACCTTTTGGACAAGCAATCCAAGATGTCCTAGAAAAAACTTTAGAGATTT

GTCGAGACATAGGTTTCACTACCTATCTTGACCCTAAAGGTTATTACGGATATGCAGAAATCGGTCAGGGAGCAG

AGCTTCTGGCCATTCTCTGTCATTTGGATGTTGTTCCATCAGGTGATGAAGCAGATTGGCAGACACCGCCATTTGA

AGCAACTATCAAAGACGGCTGGGTATTCGGACGTGGTGTCCAAGATGATAAAGGCCCTTCGCTCGCAGCTCTCTA

TGCAGTAAAAAGCTTGCTGGACCAAGGTATTCAGTTCAAAAAGCGCGTACGCTTTATCTTTGGTACCGATGAGGA

AACCCTCTGGCGCTGCATGGCACGCTACAATACCATCGAAGAACAGGCCAGTATGGGCTTTGCACCTGACTCATC

TTTTCCTCTGACCTATGCTGAAAAAGGGCTTCTACAGGTCAAACTTCATGGCCCTGGATCGGATCAACTAGAGCTT

GAAGTAGGAGGCGCCTTTAACGTTGTACCAGACAAGGCCAACTACCAAGGTCTCCTCTATGAACAGGTTTGTAAC

GGTCTCAAAGAAGCTGGTTATGATTACCAAACCACTGAACAAACCGTAACGGTTCTCGGAGTGCCAAAGCATGCT

AAGGATGCTAGTCAAGGTATCAATGCTGTCATCCGACTAGCTACCATTCTTGCTCCTCTCCAAGAACACCCTGCTC

TCAGTTTTCTTGCAACACAAGCAGGTCAAGACGGCACAGGAAGACAAATCTTTGGTGATATAGCAGATGAACCTT

CTGGTCACCTATCCTTTAATGTCGCAGGTCTCATGATCAATCATGAACGTTCTGAAATCCGTATTGACATTCGGAC

TCCTGTCTTAGCTGACAAGGAAGAACTAGTAGAGTTGCTTACAAGATGTGCACAAAACTACCAACTCCGCTACGA

AGAGTTTGACTATCTAGCGCCTCTATACGTCGCAGAAGACAGTAAACTCGTTAGCACACTGATGCAAATCTACCA

AGAAAAGACTGGCGATAACAGTCCTGCTATTTCATCCGGTGGTGCCACTTTTGCTCGCACCATGCCAAATTGTGTA

GCCTTCGGCGCCTTATTCCCAGGAGCGAAGCAGACAGAACATCAGGCAAATGAATGTGCCGTTCTAGAAGATTTG

TACCGTGCTATGGATATTTATGCCGAAGCCGTCTATCGACTTGCAACTTAA

4169.1

ATGTCTAATTCATTTGTCAAGTTGTTAGTCTCTCAATTATTTGCAAATTTAGCAGATATTTTCTTTAGAGTAACAAT

CATTGCTAACATATACATTATTTCAAAATCAGTAATTGCCACATCACTAGTTCCTATCTTAATAGGAATATCCTCTT

TTGTTGCGAGTCTTTTAGTTCCGTTGGTTACTAAAAGGTTAGCGCTAAATAGGGTTTTATCTTTATCTCAATTTGGA

AAGACTATATTATTGGCGATACTGGTAGGAATGTTTACCGTAATGCAATCCGTAGCGCCTTTGGTGACCTATCTAT

TTGTTGTTGCAATTTCCATACTAGATGGTTTTGCAGCACCCGTTTCCTATGCTATTGTGCCACGCTATGCGACCGAT

TTGGGTAAGGCTAATTCAGCCTTATCAATGACTGGTGAAGCTGTTCAATTGATAGGTTGGGGATTAGGTGGACTCT

TGTTTGCAACAATTGGTCTGTTACCTACCACGTGTATCAATTTAGTCTTGTATATCATTTCTAGCTTTCTGATGTTA

TTTCTTCCTAACGCTGAAGTGGAGGTGTTAGAGTCAGAAACTAATCTTGAAATTTTGCTCAAAGGTTGGAAGTTAG

TTGCTAGAAATCCTAGATTAAGACTTTTTGTATCAGCAAATTTATTGGAAATTTTTTCAAATACGATTTGGGTTTCT

TCCATTATACTTGTTTTTGTAACGGAGTTATTAAATAAAACGGAAAGTTACTGGGGATATTCTAATACAGCATACT

CTATTGGTATTATAATTAGTGGCTTAATTGCTTTTAGGCTATCTGAAAAGTTCCTTGCTGCTAAATGGGAACCCCA

ATTATTCACCCCAAATCTAAAAACCATCCAGAATCCTTGCCTTAGCTTAGATCCTGGATGGTTTCTTTTTTCACCCA

ATGGGTGTTTTTTACTAGACAAAAAAGAGTTTCCCCTTTATGGTATAAGTGTAGAAAAAAACACAAAAAGAAAGG

AAACTCACATGAACAGTTTACCAAATCATCACTTCCAAAACAAGTCTTTTTACCAACTATCTTTCGATGGAGGTCA

TTTAACCCAGTATGGTGGTCTTATCTTTTTTCAGGAACTTTTTTCCCAGTTGAAACTAAAAGAGCGGATTTCTAAGT

ATTTAGTAACGAATGACCAACGCCGCTACTGTCGTTATTCGGATTCAGATATCCTTGTCCAGTTCCTCTTTCAACTG

TTAACAGGTTATGGAACGGACTATGCTTGTAAAGAATTGTCAGCTGATGCCTACTT

TCCAAAATTGTTGGAAGGAGGGCAGCTTGCTTCACAGCCAACCTTATCCCGTTTTCTTTCCAGAACTGACGAGGAA

ACAGTCCATAGTTTGCGATGCCTCAACCTTGAATTGGTCGAATTCTTTTTACAGTTTCACCAGCTAAACCAACTCA

TTGTAGATATCGATTCTACCCATTTCACAACTTATGGCAAGCAAGAAGGTGTTGCTTATAACGCCCACTATCGTGC

TCATGGCTATCATCCTCTTTATGCTTTCGAGGGGAAGACAGGTTATTGTTTCAATGCCCAGCTTCGTCCTGGTAATC

GTTATTGTTCTGAAGAGGCAGACAGCTTTATCACACCTGTTTTAGAACGGTTTAATCAACTTCTCTTTCGAATGGA

TAGTGGCTTTGCGACCCCAAAATTATACGATTTAATTGAAAAAACAGGGCAATACTACCTCATAAAACTCAAGAA

AAATACTGTTCTGAGCCGTCTTGGAGACCTTTCCCTCCCTTGCCCACAGGATGAGGACTTAACCATCTTGCCCCAC

TCCGCCTACTCAGAAACTCTCTATCAAGCAGGATCTTGGTCGCACAAGCGTCGTGTCTGCCAGTTCTCTGAACGAA

AAGAAGGAAACTTGTTCTACGATGTTATTTCTCTCGTTACAAATATGACGAGTGGAACAAGCCAAGACCAGTTTCA

GCTTTATCGTGGACGTGGTCAAGCCGAGAATTTCATCAAGGAGATGAAGGAGGGATTTTTTGGCGATAAAACGGA

TAGTTCAACCTTAATCAAAAACGAAGTTCGTATGATGATGAGCTGTATCGCCTACAATCTCTATCTTTTTCTCAAA

CATCTAGCTGGAGGTGACTTCCAAACTTTAACAATCAAACGCTTCCGCCATCTTTTTCTTCACGTGGTGGGAAAAT

GTGTTCGAACAGGACGCAAGCAGCTCCTCAAATTGTCTAGTCTCTATGCCTATTCCGAATTGTTTTCAGCACTTTA

TTCTAGGATTAGAAAAGTCAACCTGAATCTTCCTGTTCCTTATGAACCACCTAGAAGAAAAGCGTCGTTAATGATG

CATTAA

4169.3

ATGATGGAGTTTTTTCAACAGCTTCCTCATTTAGAGCCATATGGCAATCCTCAGTATTTTGTTTATGTGATTGCTGC

AACCTTGCCCATCTTTATAGGTCTCTTTTTCAAGAAACGCTTTGCCTGGTATGAAGTGTTGGTAAGTCTCTTCTTTA

TTGTCACCATGTTGGTGGGTGGAAAGACCAATCAACTAGCTGCCTTGGGTATTTACCTTTGCTGGGAAATATTGCT

CCTGCTTTTCTACAAGCATTATCGAAAAAGCAAGGATGGCAAGTGGGTCTTCTACTTAGTTAGTTTTCTGTCCCTA

CTTCCGATTATCTTTGTCAAGGTGCAACCAGCTATCAATGGAACGCAGTCTTTGCTTGGGTTCTTGGGAATTTCTTA

CCTGACCTTTCGTTCGGTTGGAATTGTCATCGAGCTGAGAGATGGAGTGATTAAGGATTTTACCCTCTGGGAATTC

CTCCGTTTCCTTCTCTTCATGCCAACTTTCTCGAGTGGTCCAATCGATCGCTTTAAGCGATTTAATGAAAATTATCA

GGCTATTCCTGAGCGAGATGAGTTGATGGATATGCTGGATGAATCTGTCCGCTATATCATGTGGGGCTTTTTGTAT

AAGTTTATCCTAGCTCATGTTTTAGGAGAGACCTTACTACCTCCTCTGAAGAATTTAGCCTTGCAGTCAGGTGGCT

TCTTTAATCTCTATGCCTTGGCAGTTATGTATACTTTTGGTCTGGAACTCTTCTTTGACTTTGCAGGTTATTCTATGT

TTGCTTTGGCCATCTCAAACTTGATGGGAATCCGTAGCCCTATCAACTTTAACAAGCCCTTTTTATCAAGGGATTT

AAAGGAGTTTTGGAATCGCTGGCATATGAGTCTGTCCTTCTGGTTCCGTGACTTTGTCTTTATGCGAATGGTGATG

GTGTTAACCAGAAAGAAAGTCTTTAAAAATCGTAATGTAACCTCAAGCATGGCCTACATTGTAAATATGCTGATTA

TGGGATTTTGGCATGGTGTGACCTGGTACTATATCGCCTATGGACTCTTTCATGGACTAGGCTTGGTCATCAATGA

TGCCTGGGTTCGCAAGAAAAAAACGCTCAATAAGGAACGGAAAAAAGCAGGGAAGGCTGCCCTACCTGAGAATC

GCTGGATTCAGTTGCTTGGCATGGTTGTCACTTTCCATGTTGTCATGTTGTCATTCTTAATCTTTTCTGGATTCTTGA

ATAATCTATGGTTTAAAAAATAA

4169.4

ATGCTTAAACGCTTATGGATGATCTTCGGACCGGTCTTGATCGCTGGTTTGTTGGTTTTTCTGCTCATTTTCTTTTAT

CCTACTGAGATGCATCATAATCTAGGAGCTGAAAAGCGTTCAGCAGTGGCTACTACTATCGATAGTTTTAAGGAGC

GAAGTCAAAAAGTCAGAGCACTATCTGATCCAAATGTGCGTTTTGTTCCCTTCTTTGGCTCTAGTGAATGGCTTCG

TTTTGACGGTGCTCATCCTGCGGTATTAGCTGAGAAATACAATCGTTCCTACCGTCCTTATCTTTTAGGACAGGGG

GGAGCTGCATCGCTTAACCAATATTTTGGAATGCAACAGATGTTACCACAGCTGGAGAATAAACAAGTTGTGTAT

GTTATCTCACCTCAGTGGTTCAGTAAAAATGGCTATGATCCAGCAGCCTTCCAGCAGTATTTTAATGGAGACCAGT

TGACTAGTTTTCTGAAACATCAATCTGGGGATCAGGCTAGTCAATATGCAGCGACTCGCTTACTGCAACAGTTCCC

AAACGTAGCTATGAAGGACCTGGTTCAGAAGTTGGCAAGTAAAGAAGAATTGTCGACAGCAGACAATGAAATGAT

TGAATTATTGGCTCGTTTTAATGAACGCCAAGCTTCCTTTTTTGGTCAGTTTTCGGTTAGAGGCTATGTTAACTACG

ATAAGCATGTAGCTAAGTATTTAAAAATCTTGCCAGACCAGTTTTCTTATCAGGCAATAGAAGATGTTGTCAAAGC

AGATGCTGAAAAAAATACTTCCAATAATGAGATGGGAATGGAAAATTATTTCTATAATGAGCAGATCAAGAAGGA

TTTGAAGAAATTAAAGGATTCTCAGAAAAGCTTTACCTATCTCAAGTCGCCAGAGTATAATGACTTGCAGTTGGTT

TTAACACAGTTTTCTAAATCTAAGGTAAACCCGATTTTTATCATTCCACCTGTTAATAAAAAATGGATGAACTATG

GTGGTCTACGAGAGGATATGTACCAACAAACGGTGCAGAAGATTCGCTACCAGTTAGAAAGTCAAGGTTTTACCA

ATATAGCAGATTTTTCTAAGGACGGCGGGGAGCCTTTCTTTATGAAGGACACCATTCACCTTGGTTGGTTGGGTTG

GTTGGCTTTTGACAAGGCAGTTGATCCTTTCCTATCCAATCCCACACCAGCTCCGACTTACCATCTGAATGAGCGC

TTTTTCAGCAAAGATTGGGCGACTTATGATGGAGATGTCAAAGAATTTCAATAG

4169.6

ATGGAGAAAAACCTCAAGGCTTTGAAACAAACAACAGACCAAGAAGGCCCAGCAATTGAACCTGAAAAGGCAGA

GGATACCAAGACAGTCCAAAATGGTTACTTCGAGGATGCAGCTGTCAAGGACCGCACCTTGAGTGACTATGCAGG

TAACTGGCAATCAGTTTATCCTTTCCTTGAAGACGGCACGTTTGACCAAGTCTTTGACTACAAGGCTAAGTTGACT

GGTAAGATGACCCAGGCTGAGTACAAGGCTTACTATACAAAAGGCTATCATACAGATGTGACTAAGATTAACATT

ACTGATAATACTATGGAATTTGTTCAAGGTGGACAAAGCAAGAAATACACTTACAAGTATGTCGGTAAGAAAATT

TTGACTTACAAGAAAGGCAATCGTGGCGTGCGTTTCCTCTTTGAAGCCACAGATGCTGACGCTGGACAATTCAAGT

ATGTTCAGTTTAGTGACCACAATGTTGCCCCAGTTAAGGCAGAACATTTCCATATCTTCTTTGGAGGCACAAGCCA

AGAAGCCCTCTTTGAAGAAATGGACAACTGGCCAACCTACTACCCAGATAACCTATCTGGCCAAGAAATCGCCCA

AGAAATGTTGGCGCATTGA

4170.3

ATGAAAGATGGTCATTTGCTAGCCCATCATATTCGTTTGTTGAATGGGCGGATTTTTCAAAAGTTACTGAGTCAAG

ATCCTGAGGCTCTTTATAGGGGTGAACAGGGCAAGATTTTAGCGGTTTTATGGAATAGTGAAACTGGCTGCGCAA

CTGCGACAGATATCGCGCTTGCGACTGGACTTGCGAATAATACGCTGACGACTATGATAAAAAAGCTAGAGGAAC

AAAAGCTTGTAATTGTTAGTCCGTGTGGAAAAGACAAGCGTAAGAAGTATTTAGTTTTAACGGAGTTAGGCAAGT

CCCAGAAAGAAGTGGGGCATCGTGTCAGTCAGAAATTGGATACTATCTTTTACAAAGGATTTTCAGAGGAAGAAA

TTCACCAATTTGAAGGTTTTCAAGAAAGAATTTTGGCGAATCTGAAAGAGAAGGGAAATGAGGTTTAG

4170.4

ATGACTAATTTAATTGCAACTTTTCAGGATCGTTTTAGTGATTGGTTGACAGCTCTATCTCAACATTTGCAGTTGTC

GCTTTTGACCTTGTTACTAGCTATTTTGCTTGCGATTCCCTTGGCTGTTTTTCTTCGCTATCATGAGAAGCTGGCCG

ACTGGGTCTTGCAGATTGCAGGTATTTTCCAGACCATCCCGTCTCTGGCCTTGTTGGGGCTCTTTATCCCTTTGATG

GGAATTGGGACCTTGCCGGCTTTGACAGCTCTAGTGATTTATGCGATTTTCCCTATTTTGCAAAATACTATCACTG

GGCTGAAGGGAATTGATCCGAACCTGCAAGAGGCTGGGATTGCCTTTGGGATGACCAGATGGGAACGTCTCAAGA

AATTTGAAATTCCACTCGCCATGCCTGTTATCATGTCTGGGATTCGGACGGCAGCTGTTTTGATTATCGGTACGGC

AACCTTGGCGGCCTTGATTGGTGCAGGGGGACTAGGTTCCTTTATTCTTTTGGGAATTGACCGTAATAATGCCAGT

TTGATTTTGATTGGGGCACTTTCTTCTGCAGTGCTAGCCATTGCCTTTAACTTCCTACTAAAAGTGATGGAAAAAG

CAAAATTACGGACGATTTTCTCAGGTTTTGCCTTGGTGGCTTTATTACTGGGTCTGTCTTATAGTCCAGCTCTTTTG

GTTCAAAAAGAGAAGGAAAACTTGGTTATTGCTGGGAAAATAGGTCCAGAACCAGAAATTTTGGCCAATATGTAT

AAGTTGCTGATTGAAGAAAATACCAGCATGACTGCGACTGTTAAACCGAATTTTGGGAAGACAAGCTTCCTTTATG

AAGCTCTGAAAAAAGGCGATATTGACATCTATCCTGAATTTACTGGTACGGTGACTGAAAGTTTGCTTCAACCATC

ACCCAAGGTGAGTCATGAACCAGAACAGGTTTATCAGGTGGCGCGTGATGGCATTGCTAAGCAGGATCATCTAGC

CTATCTCAAACCCATGTCTTATCAAAACACCTATGCTGTAGCTGTTCCGAAAAAGATTGCTCAAGAATATGGCTTG

AAGACCATTTCAGACTTGAAAAAAGTGGAAGGGCAGTTGAAGGCAGGTTTTACACTCGAGTTTAACGACCGTGAA

GATGGAAATAAGGGCTTGCAATCAATGTATGGTCTCAATCTCAATGTAGCGACCATTGAGCCAGCCCTTCGCTATC

AGGCTATTCAGTCAGGGGATATTCAAATCACGGATGCCTATTCGACTGATGCGGAATTGGAGCGTTATGATTTACA

GGTCTTGGAAGATGACAAGCAACTCTTCCCACCTTATCAAGGGGCTCCACTCATGAAAGAAGCTCTTCTCAAGAA

ACACCCAGAGTTGGAAAGAGTTCTTAATACATTGGCTGGTAAGATTACAGAAAGCCAGATGAGCCAGCTCAACTA

CCAAGTCGGTGTTGAAGGCAAGTCAGCAAAGCAAGTAGCCAAGGAGTTTCTCCAAGAACAAGGTTTGTTGAAGAA

ATGA

4170.5

ATGATGCATACTTATTTGCAAAAGAAAATTGAAAATATCAAAACAACCCTAGGTGAAATGTCAGGTGGTTACCGT

CGTATGGTTGCGGCTATGGCTGATTTAGGATTTTCAGGAACTATGAAGGCTATCTGGGATGACCTCTTTGCCCATC

GTAGTTTTGCCCAGTGGATTTATTTGCTGGTTTTAGGAAGTTTTCCTCTCTGGCTGGAGTTGGTTTACGAACATCGT

ATTGTTGACTGGATTGGGATGATTTGTAGCTTGACAGGGATTATCTGTGTAATCTTTGTATCGGAAGGTCGAGCAA

GTAATTATCTTTTTGGCTTGATTAACTCTGTTATTTACCTTATTTTGGCCCTACAGAAAGGCTTTTATGGTGAGGTG

CT?GACGACACTTTACTTCACAGTCATGCAGCCAATTGGACTTCTAGTTTGGATTTATCAGGCACAGTTTAAGAAGG

AAAAGCAGGAGTTTGTCGCGCGTAAACTGGACGGCAAGGGCTGGACAAAGTATCTTTCCATTAGTGTGCTTTGGT

GGTTGGCCTTTGGCTTCATTTATCAGTCTATTGGTGCCAATCGTCCCTATCGTGATTCAATCACAGATGCAACCAA

TGGGGTAGGGCAAATCCTCATGACAGCTGTTTACCGTGAACAGTGGATATTCTGGGCGGCTACCAATGTCTTTTCA

ATCTATCTCTGGTGGGGAGAAAGCCTGCAAATTCAAGGGAAATATCTAATTTATCTCATTAACAGTCTAGTTGGTT

GGTATCAATGGAGCAAGGCAGCTAAGCAGAATACTGATTTACTTAACTAG

4170.6

ATGAGAAATATGAAGGCAAAATATGCTGTTTGGGTGGCTTTTTTCTTAAATTTGACTTATGCCATTGTTGAGTTTAT

TGCAGGTGGAGTATTTGGTTCTAGCGCTGTTCTTGCTGACTCTGTGCATGACTTGGGAGATGCGATTGCAATTGGA

ATATCAGCTTTTCTAGAAACAATCTCCAATCGTGAAGAAGACAATCAGTACACCTTGGGCTATAAGCGGTTTAGCC

TGCTAGGAGCCTTGGTAACAGCTGTGATTCTCGTAACGGGCTCTGTTCTAGTCATTTTGGAAAATGTCACGAAGAT

TTTGCATCCGCAACCAGTCAATGATGAGGGGATTCTCTGGTTAGGAATTATTGCGATTACTATCAATCTGTTAGCG

AGTCTGGTGGTTGGTAAGGGAAAGACAAAGAATGAGTCTATTCTGAGTCTGCATTTTCTGGAAGATACGCTAGGG

TGGGTAGCTGTTATCCTGATGGCGATTGTTCTTCGATTTACGGACTGGTATATCCTAGATCCTCTTTTGTCCCTTGT

CATTTCTTTCTTTATTCTTTCAAAAGCCCTTCCACGTTTTTGGTCTACACTCAAGATTTTCTTGGATGCTGTGCCAG

AAGGTCTTGATATCAAGCAAGTAAAGAGTGGCCTGGAGCGATTGGACAATGTGGCCAGCCTTAATCAGCTTAATC

TCTGGACTATGGATGCTTTGGAAAAAAATGCCATTGTCCATGTTTGTCTAAAAGAAATGGAACATATGGAAACTTG

TAAAGAGTCTATTCGAATTTTCCTAAAAGATTGTGGTTTTCAAAATATTACCATTGAAATTGATGCTGACCTAGAA

ACTCACCAAACCCATAAGCGAAAGGTGTGTGACTTGGAACGGAGTTATGAGCATCAACATTAG

4170.8

ATGATTGAATACAAAAATGTAGCACTGCGCTACACAGAAAAGGATGTCTTGAGAGATGTCAACTTACAGATTGAG

GATGGGGAATTTATGGTTTTAGTAGGGCCTTCTGGGTCAGGTAAGACGACCATGCTCAAGATGATTAACCGTCTTT

TGGAACCAACTGATGGAAATATTTATATGGATGGGAAGCGCATCAAAGACTATGATGAGCGTGAACTTCGTCTTT

CTACTGGTTATGTTTTACAGGCTATTGCTCTTTTTCCAAATCTAACAGTTGCGGAAAATATTGCTCTCATTCCTGAA

ATGAAGGGGTGGAGCAAGGAAGAAATTACGAAGAAAACAGAAGAGCTTTTGGCTAAGGTTGGTTTACCAGTAGCC

GAGTATGGGCATCGCTTACCTAGTGAATTATCTGGTGGAGAACAGCAACGGGTCGGTATTGTCCGAGCTATGATTG

GTCAGCCCAAGATTTTCCTCATGGATGAACCCTTTTCGGCCTTGGATGCTATTTCGAGAAAACAGTTGCAGGTTCT

GACAAAAGAATTGCATAAAGAGTTTGGGATGACAACGATTTTTGTAACCCATGATACGGATGAAGCCTTGAAGTT

GGCGGACCGTATTGCTGTCTTGCAGGATGGAGAAATTCGCCAGGTAGCGAATCCCGAGACAATTTTAAAAGCGCC

TGCAACAGACTTTGTAGCAGACTTGTTTGGAGGTAGTGTTCATGACTAA

4171.1

ATGTCAGCAGTTGCTATTTCAGCTATGACCAAGGTTATGCAAGAAACCCACGGAAATCCTTCTAGTATTCATGGTC

ATGGTCGTCAAGCTGGCAAACTCTTGCGAGAAGCCCGTCAGGAACTAGCCCAGTTACTAAGGACAAAACCTCAAC

ATATCTTTTTCACTTCTGGTGGGACTGAAGGCAATAATACTACCATCATTGGCTACTGTCTTCGTCACCAAGAACA

AGGAAAACATATCATCACAACTGCCATCGAGCACCATGCTGTCCTTGAAACAATTGATTACTTGGTTCAACACTTT

GGGTTTGAAGCAACCATTATCCAGCCAGAAAATCAAGAAATCACAGCCCAGCAAATTCAAAAGGCTTTACGTGAC

GATACGATTTTGGTTTCTACCATGTTTGTCAATAATGAGACAGGAAACCTACTGCCCATCGCTGAAATTGGCCAAA

TACTCAAGCAACACCCTGCTGCCTATCATGTTGATGCAGTTCAGGCTATTGGTAAAATCCCAATTCATTCAGAAGA

ATTGGGCATTGATTTTCTCACTGCTTCTGCCCACAAATTCCATGGTCCTAAGGGAATCGGTTTTCTCTACGCATCTA

GCATGGACTTTGATTCCTATCTACATGGCGGAGACCAGGAACAGAAAAAACGTGCAGGAACTGAAAATCTGCCTG

CCATTGTAGGCATGGTTGCAGCCCTAAAAGAAGACCTAGAAAAACAAGAAGAACATTTTCAACATGTACAAAATC

TAGAAACTGCCTTTCTGGCAGAGCTGGAGGGCATTCAGTATTACCTGAATAGAGGAAAACATCATCTCCCTTATGT

TCTCAATATTGGATTTCCTGGTCAGAAAAATGACCTCTTACTCCTTCGGCTAGATTTAGCTGGAATTTCAATCTCTA

CTGGCTCAGCCTGTACTGCAGGCGTTGTCCAATCCAGCCATGTTCTTGAAGCCATGTATGGCGCAAATTCAGAACG

CTTGAAGGAATCCCTTCGCATCAGTTTGTCGCCACAAAATACCGTTGAAGACCTACAAACCCTCGCAAAAACCTTA

AAAGAAATTATCGGAGGTTAG

4172.1

ATGTTATTCAAATTATCTAAGGAAAAAATAGAGCTAGGCTTATCTCGTTTATCGCCAGCCCGTCGTATTTTTTTGA

GTTTTGCCTTGGTCATTTTACTAGGCTCTCTTCTTTTGAGCTTGCCCTTTGTCCAAGTTGAAAGCTCACGAGCGACT

TATTTTGATCATCTTTTCACTGCTGTCTCTGCAGTCTGTGTGACGGGTCTCTCAACCCTTCCAGTAGCTCACACCTA

TAATATCTGGGGTCAAATAATCTGTTTGCTCTTGATTCAGATCGGTGGTCTAGGGCTCATGACCTTTATTGGGGTTT

TCTATATCCAGAGCAAGCAAAAGCTTAGTCTTCGTAGCCGTGCAACTATTCAGGATAGTTTTAGTTATGGAGAAAC

TCGATCTTTGAGAAAGTTTGTCTATTCTATTTTTCTCACGACCTTTTTGGTTGAGAGCTTGGGAGCTATTTTGCTTA

GTTTTCGCCTTATTCCTCAACTTGGCTGGGGACGTGGTCTTTTTAGTTCCATTTTTCTAGCGATCTCAGCCTTCTGT

AATGCCGGTTTTGATAATTTAGGGAGCACCAGTTTATTTGCTTTTCAGACCGATTTACTGGTCAATCTGGTGATTGC

AGGCTTGATTATTACAGGCGGCCTTGGTTTTATGGTCTGGTTTGATTTGGCTGGTCATGTAGGAAGAAAGAAAAAA

GGACGTCTGCACTTTCATACGAAGCTTGTACTATTATTGACTATAGGTTTGTTGTTATTTGGAACAGCAACTACTCT

CTTTCTTGAGTGGAACAATGCTGGAACGATTGGCAATCTCCCTGTTGCCGATAAGGTTTTAGTTAGCTTTTTTCAA

ACAGTGACGATGCGAACAGCTGGCTTTTCTACGATAGATTATACTCAGGCTCATCCTGTGACTCTTTTGATTTATA

TCTTACAGATGTTTCTAGGTGGGGCACCTGGAGGAACAGCTGGGGGACTCAAGATTACGACATTTTTTGTCCTCTT

GGTCTTTGCACGAAGTGAGCTTCTAGGCTTGCCTCATGCCAATGTTGCGAGACGAACGATCGCGCCGCGAACGGTT

CAAAAATCCTTTAGTGTCTTTATTATCTTTTTGATGAGCTTCTTGATAGGATTGATTCTGCTAGGGATAACAGCCAA

AGGCAATCCTCCCTTTATCCACCTCGTATTTGAAACCATTTCAGCTCTTAGTACAGTTGGTGTAACGGCAAATCTG

ACTCCTGACCTTGGGAAATTGGCTCTCACTGTTATCATGCCACTTATGTTTATGGG

ACGAATTGGTCCCTTGACCTTGTTTGTTAGCTTGGCAGATTACCATCCAGAAAAGAAAGATATGATTCACTATATG

AAAGCAGATATTAGTATTGGTTAA

4172.2

ATGTCAGATCGTACGATTGGAATTTTGGGCTTGGGAATTTTTGGGAGCAGTGTCCTAGCTGCCCTAGCCAAGCAGG

ATATGAATATTATCGCTATTGATGACCACGCAGAGCGCATCAATCAGTTTGAGCCAGTTTTGGCGCGTGGAGTGAT

TGGTGACATCACAGATGAAGAATTATTGAGATCAGCAGGGATTGATACCTGCGATACCGTTGTAGTCGCGACAGG

TGAAAATCTGGAGTCGAGTGTGCTTGCGGTTATGCACTGTAAGAGTTTGGGGGTACCGACTGTTATTGCTAAGGTC

AAAAGTCAGACCGCTAAGAAAGTGCTAGAAAAGATTGGAGCTGACTCGGTTATCTCGCCAGAGTATGAAATGGGG

CAGTCTCTAGCACAGACCATTCTTTTCCATAATAGTGTTGATGTCTTTCAGTTGGATAAAAATGTGTCTATCGTGG

AGATGAAAATTCCTCAGTCTTGGGCAGGTCAAAGTCTGAGTAAATTAGACCTCCGTGGCAAATACAATCTGAATA

TTTTGGGTTTCCGAGAGCAGGAAAATTCCCCATTGGATGTTGAATTTGGACCAGATGACCTCTTGAAAGCAGATAC

CTATATTTTGGCAGTCATCAACAACCAGTATTTGGATACCCTAGTAGCATTGAATTCGTAA

4172.3

ATGAAGTTATTGTCTATCGCAATTTCTAGCTATAATGCAGCAGCCTATCTTCATTACTGTGTGGAGTCGCTAGTGA

TTGGTGGTGAGCAAGTTGGGATTTTGATTATCAATGACGGGTCTCAGGATCAGACTCAGGAAATCGCTGAGTGTTT

AGCTAGCAAGTATCCTAATATCGTTAGAGCCATCTATCAGGAAAATAAATGCCATGGCGGTGCGGTCAATCGTGG

CTTGGTAGAGGCTTCTGGGCGCTATTTTAAAGTAGTTGACAGTGATGACTGGGTGGATCCTCGTGCCTACTTGAAA

ATTCTTGAAACCTTGCAGGAACTTGAGAGCAAAGGTCAAGAGGTGGATGTCTTTGTGACCAATTTTGTCTATGAAA

AGGAAGGGCAGTCTCGTAAGAAGAGTATGAGTTACGATTCAGTCTTGCCTGTTCGGCAGATTTTTGGCTGGGACCA

GGTCGGAAATTTCTCCAAAGGCCAGTATACCATGATGCACTCGCTGATTTATCGGACAGATTTGTTGCGTGCTAGC

CAGTTCTAA

4172.4

ATGAAATTCAATCCAAATCAAAGATATACTCGTTGGTCTATTCGCCGTCTCAGTGTCGGTGTTGCCTCAGTTGTTG

TGGCTAGTGGCTTCTTTGTCCTAGTTGGTCAGCCAAGTTCTGTACGTGCCGATGGGCTCAATCCAACCCCAGGTCA

AGTCTTACCTGAAGAGACATCGGGAACGAAAGAGGGTGACTTATCAGAAAAACCAGGAGACACCGTTCTCACTCA

AGCGAAACCTGAGGGCGTTACTGGAAATACGAATTCACTTCCGACACCTACAGAAAGAACTGAAGTGAGCGAGGA

AACAAGCCCTTCTAGTCTGGATACACTTTTTGAAAAAGATGAAGAAGCTCAAAAAAATCCAGAGCTAACAGATGT

CTTAAAAGAAACTGTAGATACAGCTGATGTGGATGGGACACAAGCAAGTCCAGCAGAAACTACTCCTGAACAAGT

AAAAGGTGGAGTGAAAGAAAATACAAAAGACAGCATCGATGTTCCTGCTGCTTATCTTGAAAAAGCTGAAGGGAA

AGGTCCTTTCACTGCCGGTGTAAACCAAGTAATTCCTTATGAACTATTCGCTGGTGATGGTATGTTAACTCGTCTA

TTACTAAAAGCTTCGGATAATGCTCCTTGGTCTGACAATGGTACTGCTAAAAATCCTGCTTTACCTCCTCTTGAAG

GATTAACAAAAGGGAAATACTTCTATGAAGTAGACTTAAATGGCAATACTGTTGGTAAACAAGGTCAAGCTTTAA

TTGATCAACTTCGCGCTAATGGTACTCAAACTTATAAAGCTACTGTTAAAGTTTACGGAAATAAAGACGGTAAAGC

TGACTTGACTAATCTAGTTGCTACTAAAAATGTAGACATCAACATCAATGGATTAGTTGCTAAAGAAACAGTTCAA

AAAGCCGTTGCAGACAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCTAGAAAAAGCCAAGGGTGAAGGT

CCATTCACAGCAGGTGTCAACCATGTGATTCCATACGAACTCTTCGCAGGTGATGGCATGTTGACTCGTCTCTTGC

TCAAGGCATCTGACAAGGCACCATGGTCAGATAACGGCGACGCTAAAAACCCAGCCCTATCTCCACTAGGCGAAA

ACGTGAAGACCAAAGGTCAATACTTCTATCAAGTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAAACAAGCGC

TCATTGACCAGTTCCGAGCAAATGGTACTCAAACTTACAGCGCTACAGTCAATGTCTATGGTAACAAAGACGGTA

AACCAGACTTGGACAACATCGTAGCAACTAAAAAAGTCACTATTAACATAAACGGTTTAATTTCTAAAGAAACAG

TTCAAAAAGCCGTTGCAGACAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCTAGAAAAAGCCAAGGGTG

AAGGTCCATTCACAGCAGGTGTCAACCATGTGATTCCATACGAACTCTTCGCAGGTGATGGTATGTTGACTCGTCT

CTTGCTCAAGGCATCTGACAAGGCACCATGGTCAGATAACGGTGACGCTAAAAACCCAGCCCTATCTCCACTAGG

TGAAAACGTGAAGACCAAAGGTCAATACTTCTATCAATTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAAACA

AGCGCTCATTGACCAGTTCCGAGCAAACGGTACTCAAACTTACAGCGCTACAGTCAATGTCTATGGTAACAAAGA

CGGTAAACCAGACTTGGACAACATCGTAGCAACTAAAAAAGTCACTATTAACATAAACGGTTTAATTTCTAAAGA

AACAGTTCAAAAAGCCGTTGCAGACAACGTTAAGACAGTATCGATGTTCCAGCAGCCTACCTAG

4172.5

ATGAAACTAAAAAGTTATATTTTGGTTGGATATATTATTTCAACCCTCTTAACCATTTTGGTTGTTTTTTGGGCTGT

TCAAAAAATGCTGATTGCGAAAGGCGAGATTTACTTTTTGCTTGGGATGACCATCGTTGCCAGCCTTGTCGGTGCT

GGGATTAGTCTCTTTCTCCTATTGCCAGTCTTTACGTCGTTGGGCAAACTCAAGGAGCATGCCAAGCGGGTAGCGG

CCAAGGATTTTCCTTCAAATTTGGAGGTTCAAGGTCCTGTAGAATTTCAGCAATTAGGGCAAACTTTTAATGAGAT

GTCCCATGATTTGCAGGTAAGCTTTGATTCCTTGGAAGAAAGCGAACGAGAAAAGGGCTTGATGATTGCCCAGTT

GTCGCATGATATTAAGACTCCTATCACTTCGATCCAAGCGACGGTAGAAGGGATTTTGGATGGGATTATCAAGGA

GTCGGAGCAAGCTCATTATCTAGCAACCATTGGACGCCAGACGGAGAGGCTCAATAAACTGGTTGAGGAGTTGAA

TTTTTTGACCCTAAACACAGCTAGAAATCAGGTGGAAACTACCAGTAAAGACAGTATTTTTCTGGACAAGCTCTTA

ATTGAGTGCATGAGTGAATTTCAGTTTTTGATTGAGCAGGAGAGAAGAGATGTCCACTTGCAGGTAATCCCAGAGT

CTGCCCGGATTGAGGGAGATTATGCTAAGCTTTCTCGTATCTTGGTGAATCTGGTCGATAACGCTTTTAAATATTC

TGCTCCAGGAACCAAGCTGGAAGTGGTGGCTAAGCTGGAGAAGGACCAGCTTTCAATCAGTGTGACCGATGAAGG

GCAGGGTATTGCCCCAGAGGATTTGGAAAATATTTTCAAACGCCTTTATCGTGTCGAAACTTCGCGTAACATGAAG

ACAGGTGGTCATGGATTAGGACTTGCGATTGCGCGTGAATTGGCCCATCAATTGGGTGGGGAAATCACAGTCAGC

AGCCAGTACGGTCTAGGAAGTACCTTTACCCTCGTTCTCAACCTCTCTGGTAGTGAAAATAAAGCCTAA

4172.6

ATGTTTGGTCAAACGGCTCAACATGGTCTTACGAATAGCCTGAAAGACTTCTGGATTTTTCTGCTGAATATAGGTC

CACAATTGGCGTTTTTTTGCCAGATGCTCCGCTGTTCCAGATCGGTTGAGCAGGGTACTGGAAATCACCGTCGTGA

GTTCAATATGATTCAGCAGATATTCTCGCATTTTGGGATGACTCACTTGGGAAAATCAAGTTGGTCTATCAAGAG

TCGATTGACCTTGAGTTGCTGGTCAATGCACTTAATCATCACTTGCTCATTGACAGACTGGTCCTCACGCCCAATC

AAATAACGATAGAAATCGACAGGCAGATAGTACATGGTCTTGACCTGCTGAAGGGGCGTAAAGACAAAGAGATTA

TCGACATAAAAAGTATGTTCAGGCAGTTAGAACTGGCTAGCACGCAACAAATCTGTCCGATAAATCAGCGAGTGC

ATCATGGTATACTGGCCTTTGGAGAAATTTCCGACCTGGTCCCAGCCAAAAATCTGCCGAACAGGCAAGACTGA

4174.1

ATGGAACATTTAGCAACTTATTTTTCAACCTATGGAGGAGCTTTCTTCGCTGCATTGGGAATTGTATTGGCGGTTG

GATTAAGCGGTATGGGGTCTGCTTATGGAGTTGGTAAGGCTGGGCAATCTGCCGCAGCTTTACTGAAAGAACAGC

CTGAAAAGTTTGCCTCAGCTTTGATATTGCAATTATTGCCCGGAACACAAGGATTATATGGTTTTGTTATTGGAAT

TTTAATTTGGTTGCAATTAACTCCAGAACTTCCTTTAGAAAAAGGCGTTGCTTATTTCTTTGTAGCTCTTCCAATTG

CTATTGTAGGATACTTTTCAGCTAAGCATCAAGGAAATGTAGCAGTAGCGGGAATGCAAATCTTGGCTAAAAGAC

CAAAAGAATTCATGAAGGGAGCAATTTTAGCTGCCATGGTAGAAACCTATGCAATTCTTGCTTTTGTCGTATCATT

CATTTTGACCCTTCGTGTATAA

4175.2

ATGTTAAAATCAGAAAAACAATCACGTTATCAAATGTTAAATGAAGAATTGTCCTTCCTATTGGAAGGCGAAACC

AATGTTTTGGCTAATCTTTCCAACGCCAGTGCTCTCATAAAATCACGTTTTCCTAATACCGTATTTGCAGGCTTTTA

TTTGTTCGATGGAAAGGAATTGGTTTTAGGCCCCTTCCAAGGAGGTGTTTCCTGCATCCGTATTGCACTAGGCAAG

GGTGTTTGTGGTGAGGCAGCTCACTTTCAGGAAACTGTTATTGTTGGAGATGTGACGACCTATCTCAACTATATTT

CTTGTGATAGTCTAGCTAAAAGTGAAATTGTGGTGCCGATGATGAAGAATGGTCAGTTACTTGGAGTTCTGGATCT

GGATTCTTCAGAGATTGAGGATTACGATGCTATGGATCGAGATTATTTGGAACAATTTGTCGCTATTTTGCTTGAA

AAGACAGCATGGGACTTTACGATGTTTGAGGAAAAATCTTAA

4175.3

ATGTCAGTATTAGAGATCAAAGATCTTCACGTTGAGATTGAAGGAAAAGAAATTTTAAAAGGGGTTAACCTGACC

CTGAAAACAGGAGAAATTGCCGCTATCATGGGACCAAATGGTACAGGTAAATCGACTCTTTCTGCCGCTATCATG

GGAAATCCAAACTATGAAGTAACTAAAGGTGAAGTTTTGTTTGATGGCGTAAACATCCTTGAGTTGGAAGTGGAT

GAGCGTGCGCGTATGGGACTTTTCCTTGCTATGCAATACCCATCAGAAATCCCTGGAATTACCAATGCTGAGTTTC

TTCGTGCCGCTATGAATGCGGGTAAAGAAGATGATGAGAAGATTTCAGTTCGTGAGTTTATTACTAAGCTAGATGA

AAAAATGGAATTGCTCAACATGAAAGAAGAAATGGCAGAGCGTTACCTCAACGAAGGCTTCTCTGGTGGTGAGAA

AAAACGCAATGAAATTCTTCAACTTTTGATGTTGGAGCCAACATTTGCTCTTTTGGACGAGATTGACTCAGGTCTT

GATATTGACGCTCTTAAAGTTGTGTCTAAAGGTGTCAATGCCATGCGTGGTGAAGGTTTTGGTGCTATGATCATCA

CTCACTACCAACGTCTTTTGAACTATATCACACCTGATGTGGTACACGTGATGATGGAAGGTCGTGTTGTCCTTTC

TGGTGGTCCAGAATTGGCTGCGCGTTTGGAACGTGAAGGATACGCAAAATTAGCTGAAGAACTTGGCTACGACTA

CAAGGAAGAATTGTAA

4174.4

ATGCCCTACAAAAGACAAAGGAGTTTTTCAATGGCACTTTCTAAACTAGATAGCCTTTATATGGCAGTGGTAGCAG

ACCATTCGAAAAATCCACATCACCAAGGGAAGTTAGAAGATGCTGAGCAAATCAGTCTCAACAATCCGACTTGTG

GGGATGTCATCAACCTCTCTGTCAAGTTTGATGCAGAGGACCGTTTGGAAGATATTGCTTTTCTAAATTCAGGATG

CACGATTTCAACTGCTTCTGCTAGTATGATGACAGATGCCGTTTTAGGAAAAACCAAACAAGAAATTTTAGAACTG

GCGACTATTTTTTCTGAAATGGTTCAAGGGCAAAAAGATGAGCGTCAAGACCAACTTGGAGACGCGGCATTCTTG

TCAGGTGTTGCCAAATTCCCTCAAAGAATCAAGTGTGCAACCCTAGCTTGGAATGCCCTTAAGAAAACAATTGAA

AATCAAGAAAAACAGTAA

4175.5

ATGAAAATTCAAGACCTATTGAGAAAAGATGTCATGTTGCTAGATTTGCAGGCAACTGAAAAAACAGCTGTCATC

GACGAGATGATTAAAAATTTGACAGACCACGGTTATGTAACAGATTTTGAAACATTTAAAGAAGGAATTTTGGCG

CGTGAAGCTTTGACTTCTACTGGTTTGGGTGATGGAATCGCAATGCCTCACAGCAAAAACGCTGCTGTCAAAGAA

GCGACAGTTCTATTTGCTAAGTCAAATAAGGGTGTTGACTACGAGAGCTTGGATGGACAAGCAACTGACCTCTTCT

TCATGATTGCAGCTCCAGAAGGTGCCAATGATACTCACTTGGCAGCCTTGGCAGAATTGTCTCAATACTTGATGAA

AGACGGTTTTGCAGACAAACTTCGTCAAGCAACATCTGCAGACCAAGTTATCGAACTTTTTGACCAAGCTTCAGAA

AAAACTGAGGAACTTGTTCAAGCACCTGCTAATGACTCTGGTGACTTTATCGTAGCTGTTACAGCTTGTACAACAG

GTATTGCCCACACTTACATGGCCCAAGAAGCCCTTCAAAAAGTAGCTGCTGAAATGGGGGTTGGTATCAAGGTCG

AAACCAACGGTGCTAGCGGTGTTGGAAATCAACTAACTGCAGAAGATATCCGTAAGGCTAAAGCTATTATCATTG

CAGCAGACAAGGCCGTTGAAATGGATCGATTTGATGGAAAACCATTGATCAATCGTCCAGTTGCTGACGGTATCC

GTAAGACAGAAGAGCTAATTAACTTGGCTCTTTCAGGAGATACTGAAGTCTACCGTGCCGCTAATGGTGCCAAAG

CTGCAACAGCCTCTAACGAAAAACAAAGCCTTGGTGGTGCCTTGTACAAACACTTGATGAGTGGTGTATCTCAAA

TGTTACCATTCGTTATCGGTGGTGGTATCATGATTGCCCTTGCCTTCTTGATTGACGGTGCTTTGGGTGTTCCAAAT

GAAAACCTTGGCAATCTTGGTTCTTACCATGAGTTAGCTTCTATGTTCATGAAAATTGGTGGAGCTGCCTTTGGTTT

GATGCTTCCAGTCTTTGCGGGTTATGTTGCCTACTCTATTGCTGAAAAACCGGGTTTGGTAGCAGGTTTCGTGGCT

GGTGCTATTGCCAAAGAAGGTTTTGCCTTTGGTAAAATTCCTTATGCCGCAGGTGGTGAAGCAACTTCAACTCTTG

CAGGTGTCTCATCTGGTTTCCTAGGTGCCCTTGTTGGTGGATTTATCGCAGGTGCCTTGGTTCTTGCCATCAAGAAA

TACGTTAAAGTTCCTCGTTCACTCGAAGGTGCTAAATCAATCCTTCTATTGCCACTTCTTGGAACAATCTTGACAG

GATTTGTTATGCTAGCTGTGAATATCCCAATGGCTGCAATCAACACTGCTATGAATGACTTCCTAGGCGGTCTTGG

AGGAGGTTCAGCTGTCCTTCTTGGTATCGTCCTTGGTGGAATGATGGCTGTTGACATGGGTGGACCAGTTAATAAA

GCAGCTTATGTCTTTGGTACAGGTACGCTTGCAGCAACTGTTTCTTCAGGTGGTTCTGTAGCCATGGCAGCAGTTA

TGGCTGGAGGAATGGTGCCACCACTTGCAATCTTTGTCGCAACTCTTCTTTTCAAAGATAAATTTACTAAGGAAGA

ACGTAACTCTGGTTTGACAAACATCATCATGGGCTTGTCATTTATCACTGAGGGAGCGATTCCATTTGGTGCCGCT

GACCCAGCTCGTGCGATTCCAAGCTTCATCCTTGGTTCAGCAGTAGCAGGTGGACTCGTTGGTCTTACTGGTATCA

AACTCATGGCGCCACACGGAGGAATCTTCGTTATCGCCCTTACTTCAAATGCTCTCCTTTACCTCGTTTCTGTCTTG

GTAGGAGCAATCGTAAGTGGTGTGGTTTATGGTTACCTACGCAAACCACAAGCATAA

4175.6

ATGGCAAACAAGAATACAAGTACAACAAGACGGAGACCGTCTAAAGCAGAACTGGAAAGAAAAGAAGCGATTCA

ACGAATGTTGATTTCGTTAGGAATTGCGATTTTATTGATTTTCGCAGCCTTCAAATTAGGGGCTGCAGGTATAACC

CTTTATAATTTAATTCGCTTGCTAGTGGGTAGCCTAGCTTATCTGGCGATATTCGGCCTATTAATCTATCTCTTCTT

TTTCAAGTGGATACGAAAACAGGAAGGACTCTTATCTGGCTTTTTCACCATATTTGCTGGCTTACTCTTGATTTTTG

AGGCCTACTTGGTTTGGAAATATGGTTTGGACAAGTCCGTTCTAAAAGGGACCATGGCTCAGG?TTGTGACAGATCT

GACTGGTTTTCGAACGACTAGCTTTGCTGGAGGGGGCTTGATCGGGGTCGCTCTTTATATTCCAACAGCCTTTCTC

TTTTCAAATATCGGAACTTACTTTATTGGTTCTATCTTGATTTTAGTGGGTTCTCTCCTAGTCAGCCCTTGGTCTGTT

TACGATATTGCTGAATTTTTCAGTAGAGGCTTTGCCAAATGGTGGGAAGGGCACGAGCGTCGAAAAGAGGAACGC

TTTGTCAAACAAGAAGAAAAAGCTCGCCAAAAGGCTGAGAAAGAGGCTAGATTAGAACAAGAAGAGACTGAAAA

AGCCTTACTCGATTTGCCTCCTGTTGATATGGAAACGGGTGAAATTCTGACAGAGGAAGCTGTTCAAAATCTTCCA

CCTATTCCAGAAGAAAAGTGGGTGGAACCAGAAATCATCCTGCCTCAAGCTGAACTTAAATTCCCTGAACAGGAA

GATGACTCAGATGACGAAGATGTTCAGGTCGATTTTTCAGCCAAAGAAGCCCTTGAATACAAACTTCCAAGCTTA

CAACTCTTTGCACCAGATAAACCAAAAGATCAGTCTAAAGAGAAGAAAATTGTCAGAGAAAATATCAAAATCTTA

GAAGCAACCTTTGCTAGCTTTGGTATTAAGGTAACAGTTGAACGGGCCGAAATTGGGCCATCAGTGACCAAGTAT

GAAGTCAAGCCGGCTGTTGGTGTAAGGGTCAACCGCATTTCCAATCTATCAGATGACCTCGCTCTAGCCTTGGCTG

CCAAAGATGTCCGGATTGAAGCACCAATCCCTGGGAAATCCCTAATCGGAATTGAAGTGCCCAACTCCGATATTG

CCACTGTATCTTTCCGAGAACTATGGGAACAATCGCAAACGAAAGCAGAAAATTTCTTGGAAATTCCTTTAGGGA

AGGCTGTTAATGGAACCGCAAGAGCTTTTGACCTTTCTAAAATGCCCCACTTGCTAGTTGCAGGTTCAACGGGTTC

AGGGAAGTCAGTAGCAGTTAACGGCATTATTGCTAGCATTCTCATGAAGGCGAGACCAGATCAAGTTAAATTTAT

GATGGTCGATCCCAAGATGGTTGAGTTATCTGTTTACAATGATATTCCCCACCTCTTGATTCCAGTCGTGACCAAT

CCACGCAAAGCCAGCAAGGCTCTGCAAAAGGTTGTGGATGAAATGGAAAACCGTTATGAACTCTTTGCCAAGGTG

GGAGTTCGGAATATTGCAGGTTTTAATGCCAAGGTAGAAGAGTTCAATTCCCAGTCTGAGTACAAGCAAATTCCG

CTACCATTCATTGTCGTGATTGTGGATGAGTTGGCTGACCTCATGATGGTGGCCAGCAAGGAAGTGGAAGATGCTA

TCATCCGTCTTGGGCAGAAGGCGCGTGCTGCAGGTATCCACATGATTCTTGCAACTCAGCGTCCATCTGTTGATGT

CATCTCTGGTTTGATTAAGGCCAATGTTCCATCTCGTGTAGCATTTGCGGTTTCATCAGGAACAGACTCCCGTACG

ATTTTGGATGAAAATGGAGCAGAAAAACTTCTTGGTCGAGGAGACATGCTCTTTAAACCGATTGATGAAAATCAT

CCAGTTCGTCTCCAAGGCTCCTTTATCTCGGATGACGATGTTGAGCGCATTGTGAACTTCATCAAGACTCAGGCAG

ATGCAGACTACGATGAGAGTTTTGATCCAGGTGAGGTTTCTGAAAATGAAGGAGAATTTTCGGATGGAGATGCTG

GTGGTGATCCGCTTTTTGAAGAAGCTAAGTCTTTGGTTATCGAAACACAGAAAGCCAGTGCGTCTATGATTCAGCG

TCGTTTATCAGTTGGATTTAACCGTGCGACCCGTCTCATGGAAGAACTGGAGATAGCAGGTGTCATCGGTCCAGCT

GAAGGTACCAAACCTCGAAAAGTGTTACAACAATAA

4176.1

ATGAGTTATTTTAAAAAATATAAATTCGATAAATCCCAGTTCAAACTTGGTATGCGAACCTTTAAAACAGGTATTG

CTGTTTTTCTAGTTCTCTTGATTTTTGGCTTTTTTGGCTGGAAAGGTCTTCAAATTGGTGCTTTGACAGCCGTTTTTA

GCCTGAGGGAGAGTTTTGATGAGAGTGTTCATTTTGGGACTTCGCGTATTCTAGGAAATAGTATCGGTGGACTCTA

TGCCTTGGTCTTCTTCTTATTAAATACCTTTTCCACGAAGCCTTTTGGGTGACCTTGGTAGTTGTTCCAATCTGCA

CCATGTTAACCATTATGACAAATGTAGCCATGAATAACAAAGCAGGGGTTATTGGTGGTGTAGCAGCTATGTTAAT

CATTACCCTATCAATTCCAAGTGGTGAGACAATTTTGTACGTGTTTGTGCGTGTATTAGAAACGTTTATGGGAGTT

TTTGTCGCAATTATCGTAAATTACGATATTGATCGTATTCGTCTCTTTTTAGAGAAAAAAGAAAAATAA

4178.2

ATGAATAAATCAGAACACCGCCACCAACTTATACGCGCTCTTATCACAAAAAACAAGATTCATACACAGGCTGAG

TTGCAAGCCCTTCTTGCTGAGAACGACATTCAAGTAACCCAGGCAACCCTCTCACGCGACATCAAAAATATGAAC

CTATCAAAAGTCCGCGAAGAAGATAGCGCTTATTATGTTCTTAACAATGGTTCCATCTCAAAATGGGAAAAACGTC

TCGAACTCTACATGGAAGACGCCCTTGTCTGGATGCGCCCAGTTCAACACCAAGTCCTACTAAAAACCCTTCCTGG

ACTGGCTCAATCCTTTGGTTCTATCATTGATACTTTGAGCTTCCCTGACGCTATCGCTACCCTTTGTGGTAATGATG

TCTGTCTTATCATCTGTGAAGATGCAGATACTGCTCAAAAGTGCTTTGAAGAACTGAAAAAATTCGCCCCACCATT

TTTCTTTGAAGAATAA

4179.1

ATGAAAAGTATAAAATTAAATGCTCTATCTTACATGGGAATTCGTGTCTTGAATATTATTTTTCCCATCCTAACTGG

AACCTATGTCGCGCGTGTCTTGGACCGAACTGACTATGGTTACTTCAACTCAGTCGACACTATTTTGTCATTTTTCT

TGCCCTTTGCAACTTATGGTGTCTATAACTACGGTTTAAGGGCTATCAGTAATGTCAAGGATAACAAAAAAGATCT

TAACAGAACCTTTTTCTAGTCTTTTTTATTTGTGCATCGCTTGTACGATTTTGACCACTGCTGTCTATATCCTAGCCT

ATCCTCTCTTCTTTACTGATAATCCAATCGTCAAAAAGGTCTACCTTGTTATGGGGATTCAACTCATTGCCCAGATT

TTTTCAATCGAATGGGTCAATGAAGCTCTGGAAAATTACAGTTTTCTCTTTTACAAAACTGCCTTCATCCGTATCCT

GATGCTGGTCTCTATTTTCTTATTTGTTAAAAATGAACACGATATTGTTGTCTATACACTTGTGATGAGTTTATCGA

CGCTGATTAACTACCTGATTAGTTATTTTTGGATTAAAAGAGACATCAAACTTGTTAAAATTCACCTAAGTGATTT

TAAACCACTCTTTTCTCCCTCTGACAGCCATGTTAGTCTTTGCCAATGCCAATATGCTCTTCACTTTTTTAGATCGCC

TCTTCCTCGTTAAAACAGGGATTGATGTCAACGTTAGTTACTATACCATAGCTCAGCGAATTGTGACCGTTATAGC

TGGGGTTGTAACAGGTGCAATTGGAGTGAGTGTGCCTCGTCTCAGTTACTATCTGGGGAAAGGAGACAAAGAAGC

CTATGTTTCTCTGGTTAATAGAGGTAGTCGAATCTTTAACTTCTTTATCATTCCACTGAGTTTTGGACTCATGGTTT

TAGGACCAAATGCCATCCTACTTTACGGTAGTGAAAAATATATCGGAGGCGGCATCTTGACCTCTCTCTTCGCTTT

TCGTACGATTATCCTGGCCTTAGATACCATTCTTGGTTCCCAAATTCTCTTTACCAATGGCTATGAAAAACGTATC

ACAGTCTATACAGTCTTTGCTGGGCTACTCAATTTGGGCTTGAATAGTCTCCTTTTTTTCAACCATATCGTGGCTCC

TGAATACTACTTACTGACAACTATGCTATCAGAGACTTCTCTACTTGTTTTCTATATCATTTTCATCCATAGAAAAC

AACTCATCCACTTGGGACATATCTTTAGCTATACTGTTCGATACTCTCTCTTTTCACTTTCCTTTGTAGCAATTTATT

TCCTGATTAATTTCGTGTATCCTGTAGATATGGTCATTAATTTGCCATTTTTGATTA

ATACTGGTTTGATTGTCTTGCTATCAGCTATCTCTTATATTAGTCTACTTGTCTTCACAAAAGATAGCATTTTCTAT

GAATTTTTAAACCATGTCCTAGCCTTAAAAAATAAATTTAAAAAATCATAG

4179.2

ATGAAACAACTAACCGTTGAAGATGCCAAACAAATTGAATTAGAAATTTTGGATTATATTGATACTCTCTGTAAAA

AGCACAATATCAACTATATTATTAACTACGGTACTCTGATTGGGGCGGTTCGACATGAGGGCTTTATCCCTTGGGA

CGACGATATTGATCTGTCCATGCCTAGAGAAGACTACCAACGATTTATTAACATTTTTCAAAAGGAAAAAAGCAA

GTATAAGCTCCTATCCTTAGAAACTGATAAGAACTACTTTAACAACTTTATCAAGATAACCGACAGTACGACTAAA

ATTATTGATACTCGAAATACAAAAACCTATGAGTCTGGTATCTTTATCGATATTTTCCCTATAGATCGCTTTGATGA

TCCTAAGGTCATTGATACTTGTTATAAACTGGAAAGCTTCAAACTGCTGTCTTTCAGTAAACATAAAAATATTGTC

TATAAGGATAGCCTTTTAAAAGATTGGATACGAACAGCCTTCTGGTTACTCCTTCGACCGGTTTCTCCTCGTTATTT

TGCAAATAAAATCGAGAAAGAAATTCAAAAATATAGTCGTGAAAATGGGCAATATATGGCTTTTATCCCTTCAAA

ATTTAAGGAAAAGGAAGTCTTCCCAAGTGGTACCTTTGATAAAACAATCGATTTACCCTTTGAGAATTTAAGCCTT

CCTGCACCTGAAAAATTTGATACTATTTTGACACAATTTTATGGAGATTATATGACCCTACCACCAGAAGAAAAAC

GCTTCTACAGTCATGAATTTCACGCTTATAAATTGGAGGATTAG

4179.3

ATGATAAAAATCAATCATCTAACCATCACACAAAACAAAGATTTACGAGATCTTGTATCTGACCTAACCATGACC

ATCCAAGACGGGGAAAAGGTTGCTATTATTGGTGAAGAAGGAAATGGCAAATCAACCTTACTTAAAATTTTAATG

GGGGAAGCTTTGTCTGATTTCACTATCAAGGGAAACATCCAATCTGACTATCAGTCACTGGCCTACATTCCTCAAA

AAGTCCCTGAGGACCTAAAAAAGAAAACTTTACACGACTACTTCTTTTTAGATTCTATTGATTTAGACTACAGTAT

CCTCTATCGTTTGGCGGAGGAATTGCATTTTGATAGCAATCGTTTCGCAAGTGACCAAGAGATTGGCAATCTATCA

GGGGGCGAAGCTTTGAAAATTCAGCTTATCCATGAGTTAGCCAAACCCTTTGAGATTCTATTTTTAGATGAACCTT

CAAATGACCTAGACCTTGAGACAGTTGATTGGCTAAAAGGCCAGATTCAAAAGACCAGGCAAACCGTTATTTTCA

TTTCCCATGATGAAGACTTTCTTTCTGAAACGGCAGACACTATTGTTCACTTGCGACTGGTCAAACACCGTAAAGA

AGCGGAAACGCTAGTAGAGCATTTAGACTATGATAGCTATAGTGAGCAGAGAAAGGCTAATTTTGCCAAACAAAG

TCAGCAAGCTGCTAACAACCAAAGAGCCTACGATAAAACCATGGAAAAACATCGGAGAGTTAAGCAAAATGTAG

AAACTGCGCTTCGAGCTACCAAAGATAGTACTGCCGGTCGCCTATTGGCTAAAAAGATGAAAACTGTCCTCTCAC

AAGAAAAACGCTACGAAAAGGCAGCTCAGTCCATGACTCAAAAGCCACTTGAAGAGGAACAAATCCAACTTTTCT

TTTCAGACATCCAACCATTACCAGCTTCTAAAGTCTTAGTCCAACTGGAAAAAGAAAATTTGTCCATTGACGACCG

AGTTTTGGTTCAAAAACTACAACTAACTGTCCGTGGCCAAGAAAAAATCGGTATTATCGG

GCCAAATGGTGTTGGGAAATCAACTCTGTTAGCCAAGTTACAGAGACTTCTGAATGATAAAAGAGAGATTTCACT

TGGTTTTATGCCACAAGATTACCACAAAAAACTGCAATTGGATTTATCCCCAATAGCCTATCTCAGTAAAACTGGG

GAAAAAGAGGAACTACAGAAAATCCAATCTCACCTAGCTAGTCTCAATTTCAGTTATCCAGAAATGCAGCATCAA

ATTCGCTCCTTATCTGGCGGACAACAGGGAAAACTCCTGCTTTTGGATTTAGTCCTGCGCAAACCAAACTTTCTCC

TGCTGGATGAACCCACACGAAACTTTTCTCCCACTTCTCAACCCCAAATCAGAAAACTCTTTGCTACCTATCCAGG

CGGTCTCATCACTGTTTCGCATGACCGTCGTTTCTTAAAAGAAGTCTGCTCGATCATCTATCGCATGACAGAACAC

GGTTTGAAGCTAGTTAATTTAGAAGATTTATAA

4179.4

ATGAAACCAAAAACATTTTACAACTTGCTTGCCGAGCAGAATCTTCCACTTTCGGACCAGCAAAAAGAACAATTT

GAACGTTATTTTGAGCTCTTGGTCGAGTGGAATGAGAAGATTAATTTGACGGCGATTACGGACAAGGAAGAAGTT

TATCTCAAACATTTTTACGATTCGATTGCACCCATTCTTCAAGGTTTGATTCCCAATGAAACTATCAAACTTCTTGA

TATCGGGGCTGGGGCAGGATTTCCTAGTCTACCAATGAAAATTCTCTATCCGGAGTTAGATGTGACCATTATTGAT

TCACTCAATAAGCGCATCAACTTCCTACAACTCTTGGCTCAAGAACTGGATTTGAACGGAGTTCATTTCTACCACG

GACGTGCCGAAGATTTTGCCCAAGACAAGAACTTCCGTGCTCAATATGATTTTGTAACAGCTCGTGCGGTTGCCCG

TATGCAGGTCCTATCTGAATTGACTATTCCCTACCTTAAGGTTGGTGGCAAACTATTAGCACTCAAGGCTAGCAAT

GCGCCTGAGGAATTATTAGAAGCTAAGAATGCCCTCAATCTCCTTTTTAGTAAGGTCGAAGACAATCTCAGctACG

CCCTACCGAATAGAGATCCGCGCTATATCACAGTGGTAGAAAAGAAAAAAGAAACACCAAATAAATATCCACGTA

AGGCTGGTATGCCAAATAAACGCCCACTTTAA

4179.6

ATGAGTATTAAACTAATTGCCGTTGATATCGACGGAACCCTTGTCAACAGCCAAAAGGAAATCACTCCTGAAGTTT

TTTCTGCCATCCAAGATGCCAAAGAAGCTGGTGTCAAAGTCGTGATTGCAACTGGCCGCCCTATCGCAGGCGTTGC

CAAACTTCTAGACGACTTGCAGTTGAGAGACGAGGGGGACTATGTGGTAACCTTCAACGGTGCCCTTGTCCAAGA

AACTGCTACAGGACATGAGATTATCAGCGAATCCTTGACTTATGAGGATTATCTAGATATGGAATTCCTCAGTCGC

AAGCTCGGTGTCCACATGCATGCCATTACCAAGGACGGTATCTATACTGCAAATCGCAATATCGGAAAATACACT

GTACACGAATCAACCCTCGTCAGCATGCCTATCTTCTACCGTACCCCTGAAGAAATGGCTGGCAAAGAAATTGTTA

AATGTATGTTTATCGATGAACCAGAAATTCTCGATGCTGCGATTGAAAAAATTCCAGCAGAATTTTACGAGCGCTA

CTCCATCAACAAATCTGCTCCTTTCTACCTCGAACTCCTTAAAAAGAATGTAGACAAGGGTTCAGCCATTACTCAC

TTGGCTGAAAAACTCGGATTGACCAAAGATGAAACCATGGCAATCGGTGATGAAGAAAATGACCGTGCCATGCTG

GAAGTCGTTGGAAACCCCGTTGTCATGGAAAATGGAAATCCAGAAATCAAAAAAATCGCCAAATACATCACCAAA

ACAAATGACGAATCCGGCGTTGCCCATGCCATCCGAACATGGGTACTGTAA

4179.7

ATGACTTGGATTATTCTTGGAGTTATCGCTCTTATTGTTATTTTTGTGATTGTTAGCTATAACGGTTTGGTTAAAAA

TCGTATGCAAACCAAGGAGGCTTGGAGTCAGATTGATGTTCAGTTGAAACGTCGCAATGACCTCTTGCCAAACTTG

ATTGAGACTGTAAAAGGTTATGCCAAATATGAAGGTTCTACCCTTGAAAAGGTGGCAGAACTACGTAACCAAGTG

GCGGCAGCGACTTCACCAGCAGAAGCTATGAAAGCCAGTGATGCCCTCACTCGTCAGGTTTCAGGTATTTTTGCAG

TTGCAGAAAGCTATCCAGATTTGAAAGCTAGTGCTAACTTTGTTAAATTGCAAGAGGAGTTGACAAACACAGAAA

ATAAAATTTCTTACTCTCGTCAACTCTATAACAGTGTTGTCAGCAACTACAATGTAAAATTAGAAACTTTCCCGAG

CAATATTATCGCTGGAATGTTTGGATTTAAAGCGGCAGATTTCCTTCAAACACCTGAAGAGGAAAAGTCGGTTCCT

AAAGTTGATTTTAGCGGTTTAGGTGACTAA

4179.8

ATGTTGTTTGATCAAATTGCAAGCAATAAACGAAAAACCTGGATTTTGTTGCTGGTATTTTTCCTACTCTTAGCTCT

TGTTGGTTATGCGGTTGGTTATCTCTTTATAAGATCTGGACTTGGTGGTTTGGTTATTGCACTGATTATCGGCTTTA

TCTACGCTTTGTCTATGATTTTTCAATCGACAGAGATTGTCATGTCCATGAATGGAGCGCGTGAGGTGGATGAGCA

AACGGCACCAGACCTCTACCATGTAGTGGAAGATATGGCTCTGGTCGCTCAGATTCCTATGCCCCGTGTTTTCATC

ATTGATGATCCAGCCTTAAATGCCTTTGCGACAGGTTCTAATCCTCAAAATGCGGCTGTTGCTGCGACTTCAGGTC

TACTAGCTATCATGAATCGTGAAGAACTAGAAGCTGTTATGGGACATGAAGTCAGTCATATTCGTAATTATGATAT

CCGTATTTCGACTATTGCAGTTGCCCTTGCTAGTGCTATCACCATGCTTTCTAGTATGGCAGGTCGTATGATGTGGT

GGGGTGGAGCAGGTCGCAGACGAAGTGATGATGACCGAGATGGAAATGGTCTTGAAATCATTATGCTAGTGGTTT

CCCTACTAGCTATTGTACTGGCACCTCTCGCTGCAACCTTGGTTCAGCTCGCTATTTCTCGTCAGAGGGAATTTCTG

GCAGATGCATCTAGTGTCGAGCTGACTCGCAATCCCCAGGGAATGATTAATGCCCTAGATAAGTTGGACAATAGC

AAACCTATGAGTCGCCACGTCGATGATGCTAGCAGTGCCCTTTATATCAATGATCCTAAGAAAGGTGGGGGGTTC

CAAAAACTCTTTTATACCCACCCACCTATCTCAGAACGGATTGAACGTTTAAAACAGATGTAA

4179.9

ATGAAATTAAATATTCAAGAAATTCGTAAGCAGTCTGAAGGTTTGAACTTTGAACAAACGTTAGATTTAGTTGATG

ACCTGCGTGCACGTAATCAAGAAATTTTAGATGTAAAAGATATCCTTGCAGTTGGGAAAGTACAATATGAAGACC

GTATGTATTTCTTAGATTATCAACTATCTTATACCATTGTTCTTGCTTCGAGTCGCAGTATGGAGCCAGTTGAGTTA

GTTGAATCTTATCCAGTCACGGAAGTTTTCATGGAAGGCGCAACTAACCAGCTAGATCAAGAAGTTTTAGATGATG

ACTTGGTCTTGCCCATCGAAAATGGGGAGCTTGACCTTGCTGAGAGTGTATCAGACAATATCCTGCTAAACATTCC

TATCAAGGTCTTGACGGCTGAAGAAGAAGCTGGTCAAGGATTTATCTCAGGAAATGACTGGCAAATCATGACAGA

GGAAGAATACCAAGCTCAAAAAGCAGTAAAGAAAGAAGAAAACAGTCCTTTTGCTGGCTTACAAGGACTATTTGA

CGGAGATGAATAA

4179.12

ATGGAGTTATTTATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTT

TGAAAGTGCTAGAATACGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATCTCAGGTTGCCG

TAATCCAGCCGTTTTTATGGAACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCA

TCTTTCTCTATTTTAGATGACTGTTATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAA

GGGAAATCTTGACCTCCTGAAATTCCCGAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAA

GTCAGTTGAAAAAGTCATTCAAGGCTTGGAAAATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACAC

AGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAAACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTA

TCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGACCATCTGGTTCTAAGTGAATATGGACCTGGTGA

ACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTGGACTTTGTCGTGGTGTGATTGTAGCAGAG

GCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAAGGACGCGATGTCTTTGCTATTCCTG

GTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGCAAAATTGGTCACCAGTGGGC

AAGATGTTCTTGCGGAATTTGAATTTTAA

4181.1

ATGA?AACGTCAATTAGCCTTGGTCGTCTTTAGTGGTGGTCAAGATTCAACAACCTGCCTTTTCTGGGTCATGCAAC

ACTATGAAACAGTCGAAGCTGTCACCTTTGCCTACGGCCAACGTCATCACCTCGAAATTCAAATTACTAGAGAAAT

CGCTAAGGAACAGGGCATTCGTCACCATATCCTCGATATGTCTCTGCTGGGACAAATCACTGCTCAGCCAGACTTT

GCGACGATTCATATTTCCTACATTCCTGACAAGCTCTGTGTCGAGTCAAAATCCCTCAAACTATATCTATTTAGCT

ACCGAAACCACGGAGATTTCCACGAAAACTGTATCAACACCATCGGGAAAGACTTGGTCAACTTGCTAGACCCTC

GCTATTTAGAAGTCTGGGGAAAATTCACTCCGCGCGGTGGCATTTCAATCGACCCCTACTACAACTACGGTAAGCA

AGGAACTAAGTATGAGGGCTTGGCAGAACAACGCCTCTTCCAACACGACCTTTATCCAGAGAAAATTGACAACCG

CTAA

4181.2

ATGACCGAAACGGTAGAAGATAAAGTAAGTCATTCAATTACTGGGCTTGATATCCTCAAGGGGATAGTTGCTGCG

GGAGCTGTCATAAGTGGAACCGTTGCAACTCAAACGAAGGTATTTACAAATGAGTCAGCAGTACTTGAAAAAACT

GTAGAGAAAACGGATGCTTTGGCAACAAATGATACAGTAGTTCTAGGTACGATATCTACAAGTAATTCAGCGGAGT

TCAACTAGTTTGTCAGCTTCAGAGTCGGCAAGTACATCTGCATCTGAGTCAGCCTCAACCAGCGCTTCGACCTCAG

CAAGTACAAGTGCATCAGAATCAGCAAGTACATCGGCTTCGACAAGTATTTCTGCATCATCTACTGTGGTAGGTTC

ACAAACAGCTGCCGCTACAGAAGCAACTGCTAAGAAGGTCGAAGAAGATCGTAAGAAACCAGCTAGTGATTATGT

AGCATCAGTTACAAATGTCAATCTCCAATCTTATGCTAAGCGACGCAAGCGTTCAGTGGATTCCATCGAGCAATTG

CTGGCTTCTATAAAAAATGCTGCTGTTTTTTCTGGCAATACGATTGTAAATGGCGCCCCTGCAATTAATGCAAGTC

TAAACATTGCTAAAAGTGAGACAAAAGTTTATACAGGTGAAGGTGTAGATTCGGTATATCGTGTTCCAATTTACTA

TAAATTGAAAGTGACAAATGATGGTTCAAAATTGACCTTTACCTATACGGTTACGTATGTGAATCCTAAAACAAAT

GATCTTGGTAATATATCAAGTATGCGTCCTGGATATTCTATCTATAATTCAGGTACTTCAACACAAACAATGTTAA

CCCTTGGCAGTGATCTTGGTAAACCTTCAGGTGTAAAGAACTACATTACTGACAAAAATGGTAGACAGGTTCTATC

CTATAATACATCTACAATGACGACGCAGGGTAGTGGGTATACTTGGGGAAATGGTGCCCAAATGAATGGTTTCTTT

GCTAAGAAAGGATATGGATTAACATCATCTTGGACTGTACCAATTACTGGAACGGA

TACATCCTTTACATTTACCCCTTACGCTGCTAGAACAGATAGAATTGGAATTAACTACTTCAATGGTGGAGGAAAG

GTAGTTGAATCTAGCACGACCAGTCAGTCACTTTCACAGTCTAAGTCACTCTCAGTAAGTGCTAGTCAAAGCGCCT

CAGCTTCAGCATCAACAAGTGCGTCGGCTTCAGCATCAACCAGTGCCTCGGCTTCAGCGTCAACCAGTGCGTCAG

CTTCAGCAAGTACCAGTGCTTCAGTCTCAGCATCAACAAGTGCTTCAGCCTCAGCATCGACAAGTGCCTCGGCTTC

AGCAAGCACATCAGCATCTGAATCAGCGTCAACCAGTGCTTCGGCTTCAGCAAGTACCAGTGCTTCAGCTTCAGC

ATCAACCAGCGCCTCGGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGCGCCTCGGCCTCAGCAAG

CACCTCAGCTTCTGAATCGGCCTCAACCAGCGCCTCAGCCTCAGCATCAACGAGTGCTTCGGCTTCAGCAAGCAC

AAGCGCCTCGGGTTCAGCATCAACGAGTACGTCAGCTTCAGCGTCAACCAGTGCTTCAGCCTCAGCATCAACAAG

TGCGTCAGCCTCAGCAAGTATCTCAGCGTCTGAATCGGCATCAACGAGTGCGTCTGAGTCAGCATCAACGAGTAC

GTCAGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGTGCGTCAGCCTCAGCATCGACAAGCGCCTC

AGCTTCAGCAAGTACCAGTGCTTCAGCCTCAGCGTCGACAAGTGCGTCGGCCTCAACCAGTGCATCTGAATCGGC

ATCAACCAGTGCGTCAGCCTCAGCAAGTACTAGTGCATCGGCTTCAGCATCAACCAGTGCCTCGGCTTCAGCGTCA

ACCAGTGCGTCAGCTTCAGCAAGTACCAGTGCTTCAGTCTCAGCATCAACAAGTGCTTCAGCCTCAGCATCGACA

AGTGCCTCGGCTTCAGCAAGCACATCAGCATCTGAATCAGCGTCGACAAGCGCCTCAGCTTCAGCAAGTACCAGT

GCGTCAGCTTCAGCATCAACCAGCGCCTCGGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGCGCC

TCGGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGCGCCTCAGCCTCAGCATCAACGAGTGCTTCG

GCTTCAGCAAGCACAAGCGCCTCGGGTTCAGCATCAACGAGTACGTCAGCTTCAGCGTCAACCAGTGCTTCAGCC

TCAGCATCAACAAGTGCGTCAGCCTCAGCAAGTATCTCAGCGTCTGAATCGGCATCAACGAGTGCGTCTGAGTCA

GCATCAACGAGTACGTCAGCCTCAGCAAGCACCTCAGCTTCTGAATCGGCCTCAACCAGTGCGTCAGCCTCAGCA

TCGACAAGCGCCTCAGCTTCAGCAAGTACCAGTGCTTCAGCCTCAGCTCGACAAGTGCGTCGGCCTCAACCAGTG

CATCTGAATCGGCATCAACCAGTGCGTCAGCCTCAGCAAGTACTAGTGCATCAGCTTCAGCATCAACGAGTGCAT

CGGCTTCAGCATCAACCAGTGCCTCGGCTTCAGCGTCAACCAGTGCGTCAGCTTCAGCAAGTACCAGTGCTTCAGT

CTCAGCATCAACAAGTGCTTCAGCCTCAGCATCGACAAGTGCcTCGGCTTCAGCAAGCACATCAGCATCTGAATCA

GCGTCGACAAGCGCcTCAGCTTCAGCAAGTACCAGTGCGTCAGCCTCAGCGTCGACAAGTGCGTCAGCCTCAGCA

AGTACTAGTGCATCAGCTTCAGCATCAACGAGTGCATCGGCTTCGGCGTCAACCAGTGCATCAGAGTCAGCAAGT

ACCAGTGCGTCAGCTTCCGCATCAACAACTGCCTCGGCTTCAGCAAGCACCAGTGCGTCGGCTTCAGCAAGTACT

AGCGCCTCAGCCTCAGCCTCAACCAGTGCGTCAGCCTCAGCAAGTATCTCAGCGTCTGAATCGGCATCAACGAGT

GCGTCCGCTTCAGCAAGTACTAGCGCCTCAGCCTCAGCGTCAACAAGTGCATCGGCTTCAGCGTCAACGAGTGCG

TCTGAATCGGCATCAACGAGTGCGTCCGCTTCAGCAAGTACTAGCGCCTCAGCCTCAGCGTCAACAAGTGCATCG

GCTTCAGCATCAACGAGTGCGTCCGCTTCAGCAAGTACTAGCGCCTCAGCCTCAGCGTCAACAAGTGCATCGGCTT

CAGCGTCAACGAGTGCGTCTGAGTCAGCATCAACGAGTGCGTCAGCCTCAGCAAGCACATCAGCTTCTGAATCTG

CATCAACCAGTGCGTCAGCCTCAGCATCGACAAGCGCCTCAGCTTCAGCAAGTACCAGTGCGTCAGCCTCAGCGT

CGACAAGTGCGTCGGCTTCAGCAAGTACCAGTGCGTCAGCCTCAGCAAGTACCAGTGCGTCAGCCTCAGCGTCGA

CAAGTGCGTCGGCCTCAACCAGTGCATCTGAATCGGCATCAACCAGTGCGTCAGCCTCAGCAAGTACTAGTGCAT

CAGCTTCAGCATCAACGAGTGCATCGGCTTCAGCATCAACCAGTGCATCAGAGTCAGCAAGTACCAGTGCGTCAG

TTCCGCATCAACAAGTGCCTCGGCTTCAGCAAGTACTAG

4183.1

ATGGGGGTCGAAACTTGGTTTTATTCTAGCATCTGCTGGCTGGCCATCGGGCTTGGTTCCGTTTGGAAGTTTCCCT

ACATGACTGCTGCTAATGGCGGTGGAGGCTTTTTACTAATCTTTCTCATTTCCACTATTTTAATCGGTTTCCCTCTC

CTGCTGGCTGAGTTTGCCCTTGGCCGTAGTGCTGGCGTTTCCGCTATCAAAACCTTTGGAAAACTGGGCAAGAATA

ACAAGTACAACTTTATCGGTTGGATTGGCGCCTTTGCCCTCTTTATCCTCTTATCTTTTTACAGTGTTATCGGAGGA

TGGATTCTAGTCTATCTAGGTATTGAGTTTGGGAAATTGTTCCAACTTGGTGGAACGGGTGATTATGCTCAGTTAT

TTACTTCAATCATTTCAAATCCAGCCATTGCCCTAGGAGCTCAAGCGGCCTTTATCCTATTGAATATCTTCATTGTA

TCACGTGGGGTTCAAAAAGGGATTGAAAGAGCTTCGAAAGTCATGATGCCCCTGCTCTTTATCGTCTTTGTTTTTA

TCATCGGTCGCTCTCTCAGTTTGCCAAATGCCATGGAAGGGGTTCTTTACTTCCTCAAACCAGACTTTTCAAAACT

GACTAGCACTGGTCTCCTCTATGCTCTGGGACAATCTTTCTTTGCCCTCTCACTAGGGGTTACAGTCATGTTGACCT

ATGCTTCTTACTTAGACAAGAAAACCAATCTAGTCCAGTCAGGAATCTCCATCGTAGCCATGAATATCTCGATATC

CATCATGGCAGGTCTAGCCATTTTCCAAGCTCGATCCCCCTTCAATATCCAGTCTGAAGGGGGACCCAGCCTGCTC

TTTATCGTCTTGCCTCAACTCTTTGACAAGATGCCTTTTGGAACCATTTTCTACGTCCTCTTCCTCTTGCTCTTCCTT

TTTGCGACAGTCACTTTTTCTGTCGTGATGCTGGAAATCAATGTAGACAATATCACCAACCAGGATAACAGCAAAC

GTGCCAAATGGAGTGTTATTTTAGGAATTTTGACCTTTGTCTTTGGCATTCCTTCAGCCCTATCTTACGGTGTCATG

GCGGATGTTCACATTTTTGGTAAGACCTTCTTTGACGCTATGGACTTCTTGGTTTCCAATCTCCTCATGCCATTTGG

AGCTCTCTACCTTTCACTTTTTACAGGCTATATCTTTAAAAAGGCTCTTGCAATGGAGGAACTCCATCTCGATGAA

AGAGCATGGAAACAAGGACTGTTCCAAGTCTGGCTCTTCCTTCTTCGTTTCTTCGTTTCGTCATTCCAATCATCATC

ATTGTGGTCTTCATTGCCCAATTTATGTAATCAAAAAGGACTTGAGTAG

4183.5

ATGTTGAAAAAATGGCAGTTAAAAGATGTTATCTTGCTTGCTTTCTTGTCTATCTTTTTTGGTGGGGTTTTCGTTGG

TTCAGGATATGTGTATAATATTCTCAGTCTACTCTTAACACCTCTTGGTTTGCAGGCCTTTGCCAATGAAATCCTCT

TCGGTCTCTGGTGTATGGCTGCGCCCATTGCTGCCATCTTTGTTCCGAGAGTCGGAAGTGCAACGATTGGAGAAGT

GCTAGCTGCGCTTGCTGAAGTCCTTTATGGTAGCCAATTTGGTCTAGGAGCTCTTTTGTCTGGCTTTGTTCAAGGTT

TGGGAAGTGAATTTGGTTTTATCGTAACTAAGAATCGCTATGAAAGTTGGCTCTCTCTAACTGCTAATAGTATTGG

GATTACGCTTGTTAGCTTTGTCTATGAATACATTAAGTTAGGTTACTACGCCTTTTCCCTTCCGTTGTCCTTTCCTT

GCTTGTGGTACGTTTTATTTCTGTTTATTTCTTCTGTACCATCTTGGTTCGTGCCATTGTCAAACTCTATCATCAGTT

TGCAACTGGAGGAAAAGCATAG

4183.6

ATGGTCAAAGTAGCAACCCAGACACCGATTATCAGTCTCTTCTTGCTGATTTTATCCTTGGAAACATCTTTCATTCC

TTCGATTGCTCTGACTCTTTCGGTAGTCGCATTTTGTATTCTCTTTATGCTCTATTACCGTCGATTTAAAATGTTAG

CTTGGATGATCATACTTGCCATTTTACCATCTTTTGCCAACTACTGGGCAGTTCAGTTACACGGAGATGCTTCACA

GGCAGTCATGCTTGGAACGAGGGCCTTTGTGACAGTTTGTATCGGCCTTGTCTTTGTTTCCTCTGTTTCACTAAAAG

AGCTTCTCTTGTACTTGGCTCAAAAGGGGCTATCACGCTCTTGGTCCTATGCCTTGATTGTGGTATTCAATTCTTTT

CCTCTCATTCAGCAAGAAATCAAGTCCCTCAAAGAAGCTTGCCTATTACGTGGTCAAGAACTACATTTTTGGTCGC

CCTTGATTTACAGTAAGGTTCTGATGACAGTCTTTAGGTGGCGCCATCTTTACCTGAGAGCTCTATCTGCTCACGG

ATATGACGAACATGCACAGTTGAAGAATAGCTATCGGACTTTTTATATTCCTAAAAAAACAAAATTAATCTACCTG

CTTTTCTTTTTATTGCTTCAAACCAGTCTATTTTTATAA

4183.7

ATGAGAAAGCACCAATTACAAGTTCACAAATTAACCATTTTATCTATGATGATTGCCCTTGATGTAGTCCTTACAC

CTATCTTTCGAATTGAGGGAATGGCACCGATGTCCAGTGTAGTCAATATTCTAGCAGGAATCATGATGGGACCTGT

TTATGCCTTGGCTATGGCTACAGTCACAGCCTTTATCCGTATGACGACTCAAGGGATTCCGCCTTTAGCTCTCACA

GGAGCGACTTTTGGAGCCCTTCTAGCAGGTCTCTTTTATAAGTACGGTCGAAAATTTCACTATTCTGCTCTAGGAG

AGATTTTGGGAACAGGTATTATTGGTTCCATTGTTTCCTATCCTGTTATGGTACTCTTTACAGGATCAGCTGCTAAG

CTTAGCTGGTTTATCTACACGCCTCGATTTTTCGGAGCAACCTTGATTGGTACAGCGATTTCCTTTATTGCCTTTCG

ATTTTTAATCAAGCAGGAATTCTTTAAAAAAGTGCAGGGATATTTCTTTAGTGAAAGGATAGACTGA

4183.8

ATGCAGGAATTTACAAATCCCTTTCCTATAGGCTCTAGTTCCCTCATTCACTGCATTACCAATGAGATTTCTTGTGA

GATGCTGGCAAATGGGATTTTGGCTCTGGGATGCAAACCTGTCATGGCAGATGATTCCCGTGAAGTTCTTGATTTT

ACTAAGCAAAGTCAGGCTCTCTTCATCAATTTGGGGCATTTGTCAGCTGAGAAGGAAAAAGCAATCCGCATGGCA

GCTTCGTATGCAAACCAATCTTCTCTCCCGATGGTAGTAGATGCGGTTGGCGTAACGACTTCATCCATTCGTAAGA

GCTTAGTTAAAGACCTTTTAGACTATAGACCTACGGTCCTTAAAGGAAACATGTCAGAAATTCGAAGTCTTGTTGG

ATTAAAGCACCACGGCGTTGGGGTCGATGCGAGTGCTAAAGATCAAGAAACGGAGGATTTGCTTCAAGTCTTGAA

AGACTGGTGTCAGACCTATCCTGGTATGTCTTTCTTAGTCACAGGTCCCAAGGACCTCGTCGTTTCGAAAAATCAG

GTCGCTGTACTGGGAAATGGCTGTACTGAATTAGACTGGATAACAGGGACAGGAGACTTGGTTGGAGCCTTAACA

GCTGTTTTTCTCAGCCAAGGAAAGACTGGTTTTGAAGCTTCTTGCTTAGCAGTCTCTTATCTCAATATCGCTGCTGA

GAAAATAGTTGTTCAAGGAATGGGATTGGAAGAATTTCGTTACCAAGTACTCAATCAGCTTTCGCTCCTAAGAAG

AGATGAAAATTGGCTAGATACCATCAAAGGAGAGGTTTATGAATAG

4185.3

ATGAACCATAAAATCGCAATTTTATCAGATGTTCATGGCAATGCGACGGCGCTAGAAGCAGTGATTGCAGATGCT

AAAAATCAAGGGGCCAGTGAATATTGGCTTCTGGGAGATATTTTTCTTCCTGGTCCAGGCGCAAATGACTTAGTCG

CCCTGCTAAAGGACCTTCCTATCACAGCAAGTGTTCGAGGCAATTGGGATGATCGTGTCCTTGAGGCTTTAGATGG

GCAATATGGCTTAGAAGACCCACAGGAAGTTCAGCTCTTGCGTATGACACAGTATTTGATGGAGCGAATGGATCC

TGCAACGATTGTCTGGCTACGAAGCTTGCCTTTGCTGGAAAAGAAAGAAATTGACGGATTGCGCTTTTCTATCTCT

CATAATTTACCTGACAAAAACTATGGTGGTGACTTGCTAGTTGAGAATGATACAGAGAAATTTGACCAACTGCTA

GATGCGGAAACGGACGTGGCAGTTTATGGTCATGTTCACAAGCAGTTGCTTCGTTATGGAAGTCAAGGGCAACAA

ATCATCAATCCAGGGTCGATTGGCATGCCCTATTTTAATTGGGAGGCGTTAAAAAATCACCGTTCCCAGTATGCCG

TGATAGAAGTTGAAGATGGGGAATTACTCAATATCCAATTTCGTAAAGTTGCTTATGATTACGAAGCTGAGTTAGA

ATTGGCCAAGTCCAAGGGGCTTCCCTTTATCGAAATGTATGAAGAACTGCGTCGTGACGATAACTATCAGGGGCA

CAATCTGGAATTATTAGCCAGCTTAATAGAAAAGCATGGGTATGTAGAGGATGTGAAGAATTTTTTTGATTTTTTG

TAA

4186.1

ATGAATGTAAATCAGATTGTACGGATTATTCCTACTTTAAAAGCTAATAATAGAAAATTAAATGAAACATTTTATA

TTGAAACCCTTGGAATGAAGGCCTTGTTAGAAGAATCGGCCTTTCTGTCACTAGGTGACCAAACGGGTCTTGAAAA

GCTGGTTTTAGAAGAAGCTCCCAGTATGCGTACTCGTAAGGTAGAGGGAAGAAAAAAACTAGCTAGATTGATTGT

CAAGGTGGAAAATCCCTTAGAAATTGAAGGAATCTTATCTAAAACAGATTCGATTCATCGATTATATAAAGGTCA

AAATGGCTACGCTTTTGAAATTTTCTCACCAGAAGATGATTTGATTTTGATTCATGCGGAAGATGACATAGCAAGT

CTAGTAGAAGTAGGAGAAAAGCCTGAATTTCAAACAGATTTGGCATCAATTTCTTTAAGTAAATTTGAGATTTCTA

TGGAATTACATCTCCCAACTGATATCGAAAGTTTCTTGGAATCATCTGAAATTGGGGCATCCCTTGATTTTATTCC

AGCTCAGGGGCAGGATTTGACTGTGGACAATACGGTTACCTGGGACTTATCTATGCTCAAGTTCTTGGTCAATGAA

TTAGACATAGCAAGTCTTCGCCAGAAGTTTGAGTCTACTGAATATTTTATTCCTAAGTCTGAAAAATTCTTCCTTG

GTAAAGATAGAAATAATGTTGAATTGTGGTTTGAAGAAGTATGA

4186.2

ATGAAGTGGACCAAGATTATTAAAAAAATAGAAGAACAAATCGAGGCAGGGATTTATCCCGGAGCCTCTTTTGCG

TATTTTAAGGACAATCAATGGACAGAGTTCTATTTAGGCCAGAGTGACCCAGAGCATGGCTTGCAGACTGAGGCA

GGACTAGTTTATGACCTAGCTAGTGTCAGCAAGGTTGTTGGGGTTGGCACAGTTTGTACCTTCTTGTGGGAAATAG

GTCAATTAGATATTGATAGACTGGTAATAGATTTTTTACCTGAGAGTGATTATCCAGACATCACTATTCGCCAGCT

CTTGACTCATGCAACAGACCTTGATCCTTTTATTCCTAATCGTGATCTTTTAACAGCCCCTGAATTAAAGGAAGCG

ATGTTTCATCTCAACAGACGAAGTCAGCCAGCCTTTCTTTATTCGGATGTCCATTTTTTGCTGTTGGGCTTTATTTT

GGAAAGAATTTTTAATCAAGATTTGGATGTGATTTTAAAGGATCAAGTCTGGAAACCTTGGGGAATGACGGAAAC

TAAGTTTGGGCCAGTTGAGCTTGCTGTTCCAACAGTTAGAGGTGTAGAGGCAGGCATAGTGCATGATCCCAAGGC

TCGTCTCCTGGGTAGACATGCTGGGAGTGCTGGTTTATTTTCGACTATAAAGGATTTACAAATCTTTTTAGAACAC

TATTTAGCAGATGATTTTGCAAGAGACTTAAATCAAAATTTTTCTCCTTTGGATGACAAGGAACGTTCTTTAGCAT

GGAATTTGGAAGGAGATTGGCTAGACCATACGGGCTATACAGGTACCTTTATCATGTGGAATCGTCAGAAGCAAG

AAGCCACTATTTTCCTATCGAATCGTACCTATGAAAAGGACGAGAGAGCTCAATGGATATTAGACCGCAATCAAG

TGATGAACTTGATTCGCAAAGAAGAGTAA

4187.2

ATGATGAAGAAGACTTATAATCATATTTTGGTCTGGGGAGTCATTTTCTATAGCATTTGCATTGTCTGTTTTTGCTT

TACTCCTCAAGAACAATCTACCGTGGGAGTGGGAACTCCAGGTATTCAGCATCTTGGACGCCTGGTTTTTCTTTTG

ACTCCTTTCAATTCTCTCTGGAAACTGGGCGAAGTGAGTGACATTGGACAATTATGTTGGATTTTTTTACAAAATA

TCCTCAATGTCTTCTTGTTTTTTCCTCTGATTTTCCAACTCCTTTATCTATTTCCAAATTTGCGGAAAACAAAAAAG

GTCCTTCTTTTTAGTTTTCTTGTGAGTCTTGGAATCGAGTGTACGCAATTAATCTTGGACTTTTTCTTTGATTTCAAT

CGCGTCTTTGAGATTGATGATTTGTGGACCAACACTTTGGGTGGCTATCTGGCTTGGCTCCTTTATAAACGATTAC

ATAAAAACAAGGTAAGGAATTAA

4188.1

ATGAAGATTCCTCTCTTAACTTTTGCAAGGCATAAATTTGTTTATGTCTTGCTTACTTTGCTTTTTCTTGCTTTGGTT

TATCGTGATGTTTTGATGACTTATTTCTTTTTTGATATTCATGCGCCCGATCTAGCTAAATTCGATGGACAAGCAAT

TAAAAATGACTTATTAAAATCAGCATTAGATTTTCGTATTCTCCAGTTCAATCTAGGTTTTTATCAATCATTTATTA

TTCCAATCATCATTGTTTTGCTAGGTTTTCAATATATTGAGCTGAAAAATAAAGTTTTACGATTGAGTATTGGAAG

AGAAGTGAGTTATCAAGGGTTAAAAAGAAAGTTGACTTTGCAAGTTGCAAGTATCCCTTGTTTGATATATTTAGTG

ACTGTGCTGATAATTGCAATTATAACCTATTTCTTTGGGACTTTTTTCTCCTCTTGGATGGAATTCTCTATTTTCTGAT

GGAAGTGGTTTACAAAGACTCCTAGATGGAGAGATAAAAAGCTATTTGTTCTTTACTTGTGTCCTACTAATCGGTA

TTTTCATCAATGCAATCTATTTTTTACAAATAGTTGATTATGTGGGGAATGTGACTCGTTCGGCAATCACCTATTTG

ATGTTTCTTTGGCTTGGTTCTATGCTGCTTTATAGTGCCTTGCCTTACTATATGGTTCCTATGACGAGTTTGATGCA

AGCTAGCTATGGGGATGTAAGTTTGATGAAACTCTTTACTCCTTATATCCTTTATATTGTCCCTTACATGGTGCTTG

AAAAATATGAAGATAATGTTTAA

4188.2

ATGAAGATAATGTTTAAGAATTTTAACAATATTTTGCTAAATAGAAAGATTGTTTTACTACTTCGTATAGTTCTGAT

GATGATTTTGATAAACCATCTATTGTCAACAGCGGTTCAAAAGCAGGATGCTGTTATCTTTTTCAAGAGAGAATTG

ATTTCAATTTTTTCCTATAATGACTATTCTGAAGCGAATTTAGAAATCCCCAAACTATTGTTAAACCTTTCGCTTTT

CATGGTAGGATGGCTCTCTGTCATTTTACTTGAAAGTGATTTGGCAGACCATTACCATCACTTGATTCGCTATCAA

TCAAGCTCCTTTTTCGATTATACAAGGAAACGATTGGTTGTCATTTCTAAATTTTTTACTCAAGATTTGTTTTGTCTG

GTTTCTTGGTTTACTTCCTCTAGGAATTCATTTCAAAACAGTCGCACTTTTCTTTTTACTTGCTCAGTTAATGATGTT

GTACTTACTACTGTCTTATCTGATAGCACTGATTAGTGCGGGCGCTGGTTTTTCCTTTTTTCTCTATTTTTTAGCATT

TGTGGGACAAGAATGGATGATGGATCATATTGTAACAGTGTATTTAGTACTCTTAAGTTTATTAGTTATGTTGATT

GTTAGTCGCTTGGAAGAGAAATTTAAGAAAGGATAA

4188.5

ATGGGCAAAGGAGAGATGGGCAAAGGAGTTATTGGCTTGGAGTTCGACTCAGAAGTATTGGTCAACAAGGCTCCA

ACCCTTCAATTGGCAAATGGTAAAACAGCGACTTTCCTAACCCAGTATGATAGCAAGACCTTGTTGTTTGCAGTAG

ATAAGGAAGATATCGGACAGGAAATTATTGGTATAGCTAAAGGAAGCATCGAAAGTATGCATAATCTTCCTGTAA

ATCTAGCAGGTGCCAGAGTTCCTGGCGGAGTAAATGGTAGCAAAGCAGCGGTGCATGAAGTTCCAGAATTTACAG

GGGGAGTTAATGGTACAGAGCCAGCTGTTCATGAAATCGCAGAGTATAAGGGATCTGATTCGCTTGTAACTCTTAC

TACAAAAAAAGATTATACTTACAAAGTCCTCTTGCTCAGCAGGCACTTCCTGAAACAGGAAACAAGGAGAGTGA

CCTCCTAGCTTCACTAGGACTAACAGCTTTCTTCCTTGGTCTGTTTACGCTAGGGAAAAAGAGAGAACAATAA

4188.10

ATGTTTAAAGTTTTACAAAAAGTTGGAAAAGCTTTTATGTTACCTATAGCTATACTTCCTGCAGCAGGTCTACTTTT

GGGGATTGGTGGTGCACTTTCAAACCCAACCACGATAGCAACTTATCCAATACTAGACAATAGTATTTTTCAATCA

ATATTCCAAGTAATGAGCTCTGCAGGAGAGGTTGTATTCAGTAATTTGTCACTACTTCTCTGTGTGGGATTATGTA

TTGGCTTAGCGAAACGAGATAAAGGAACCGCTGCGTTAGCAGGAGTAACTGGTTACTTAGTTATGACTGCAACGA

TCAAAGCTTTGGTAAAACTTTTTATGGCAGAAGGATCTGCAATTGATACTGGAGTTATTGGAGCATTAGTTGTCGG

AATAGTTGCCGTATATTTGCACAACCGATATAACAATATTCAATTACCTTCCGCTTTAGGATTCTTTGGAGGTTCA

CGCTTCGTTCCTATTGTTACATCGTTCTCTTCTATCTTGATTGGCTTTGTCTTCTTTGTTATTTGGCCACCTTTCCAA

CAACTTTCTTGTTTCTACAGGTGGATATATTTCTCAGGCGGGTCCAATTGGAACTTTTCTATATGGATTTTTAATGAG

ACTTTCTGGAGCAGTAGGCTTACATCATATAATTTACCCTATGTTTTGGTATACTGAACTTGGTGGTGTTGAAACTG

TTGCAGGACAAACAGTGGTTGGAGCTCAAAAAATATTTTTTGCTCAATTAGCCGATTTGGCCCATTCTGGATTATT

TACAGAAGGAACAAGGTTTTTTGCAGGTCGTTTCTCAACAATGATGTTCGGTTTACCGGCTGCCTGTTTAGCGATG

TACCATAGTGTTCCTAAAAATCGTCGTAAAAAATACGCGGGTTTGTTTTTTGGAGTTGCTTTAACATCTTTTATTAC

CGGTATTACAGAACCAATTGAATTTATGTTTCTATTCGTCAGTCCGGTTCTATATGTTGTTCACGCATTCCTTGATG

GTGTTAGCTTCTTTATTGCAGACGTCTTAAATATTTCAATAGGAAACACATTTTCAGGAGGTGTAATCGATTTCACT

TTATTTGGAATTTTGCAGGGGAACGCTAAGACGAATTGGGTTCTTCAGATTCCATTTGGACTTATTTGGAGTGTTTT

GTATTATATTATTTTTAGATGGTTCATTACTCAATTCAACGTTCTAACGCCAGGGCGAGGAGAAGAAGTAGATTCT

AAAGAAATTTCTGAATCCGCAGATTCAACTTCAAATACTGCAGATTATTTAAAACAGGATAGCCTACAAATTATCA

GAGCCTTGGGTGGATCAAATAATATAGAAGATGTAGATGCTTGTGTGACACGTTTACGTGTAGCTGTAAAAGAAG

TTAATCAAGTTGATAAAGCACTTTTAAAACAAATTGGTGCAGTTGATGTCTTAGAAGTGAAGGGTGGCATTCAAGC

AATCTATGGAGCAAAAGCAATCTTATATAAAAATAGTATTAATGAAATTTTAGGTGTAGATGATTAA

4188.11

ATGAAATTTAGAAAATTAGCTTGTACAGTACTTGCGGGTGCTGCGGTTCTTGGTCTTGCTGCTTGTGGCAATTCTG

GCGGAAGTAAAGATGCTGCCAAATCAGGTGGTGACGGTGCCAAAACAGAAATCACTTGGTGGGCATTCCCAGTAT

TTACCCAAGAAAAAACTGGTGACGGTGTTGGAACTTATGAAAAATCAATCATCGAAGCGTTTGAAAAAGCAAACC

CAGATATAAAAGTGAAATTGGAAACCATCGACTTCAAGTCAGGTCCTGAAAAAATCACAACAGCCATCGAAGCAG

GAACAGCTCCAGACGTACTCTTTGATGCACCAGGACGTATCATCCAATACGGTAAAAACGGTAAATTGGCTGAGT

TGAATGACCTCTTCACAGATGAATTTGTTAAAGATGTCAACAATGAAAACATCGTACAAGCAAGTAAAGCTGGAG

ACAAGGCTTATATGTATCCGATTAGTTCTGCCCCATTCTACATGGCAATGAACAAGAAAATGTTAGAAGATGCTGG

AGTAGCAAACCTTGTAAAAGAAGGTTGGACAACTGATGATTTTGAAAAAGTATTGAAAGCACTTAAAGACAAGGG

TTACACACCAGGTTCATTGTTCAGTTCTGGTCAAGGGGGAGACCAAGGAACACGTGCCTTTATCTCTAACCTTAT

AGCGGTTCTGTAACAGATGAAAAAGTTAGCAAATATACAACTGATGATCCTAAATTCGTCAAAGGTCTTGAAAAA

GCAACTAGCTGGATTAAAGACAATTTGATCAATAATGGTTCAAATTTGACGGTGGGGCAGATATCCAAAACTTT

GCCAACGGTCAAACATCTTACACAATCCTTTGGGCACCAGCTCAAAATGGTATCCAAGCTAAACTTTTAGAAGCA

AGTAAGGTAGAAGTGGTAGAAGTACCATTCCCATCAGACGAAGGTAAGCCAGCTCTTGAGTACCTTGTAAACGGG

TTTGCAGTATTCAACAATAAAGACGACAAGAAAGTCGCTGCATCTAAGAAATTCATCCAGTTTATCGCAGATGAC

AAGGAGTGGGGACCTAAAGACGTAGTTCGTACAGGTGCTTTCCCAGTCCGTACTTCATTTGGAAAACTTTATGAAG

ACAAACGCATGGAAACAATCAGCGGCTGGACTCAATACTACTCACCATACTACAACACTATTGATGGATTTGCTG

AAATGAGAACACTTTGGTTCCCAATGTTGCAATCTGTATCAAATGGTGACGAAAAACCAGCAGATGCTTTGAAAG

CCTTCACTGAAAAAGCGAACGAAACAATCAAAAAAGCTATGAAACAATAG

4188.12

ATGCAATCTACAGAAAAAAAACCATTAACAGCCTTTACTGTTATTTCAACAATCATTTTGCTCTTGTTGACTGTGC

TGTTCATCTTTCCATTCTACTGGATTTTGACAGGGGCATTCAAATCACAACCTGATACAATTGTTATTCCTCCTCAG

TGGTTCCCTAAAATGCCAACCATGGAAAACTTCCAACAACTCATGGTGCAGAACCCTGCCTTGCAATGGATGTGG

AACTCAGTATTTATCTCATTGGTAACCATGTTCTTAGTTTGTGCAACCTCATCTCTAGCAGGTTATGTATTGGCTAA

AAAACGTTTCTATGGTCAACGCATTCTATTTGCTATCTTTATCGCTGCTATGGCGCTTCCAAAACAAGTTGTCCTTG

TACCATTGGTACGTATCGTCAACTTCATGGGAATCCATGATACTCTCTGGGCAGTTATCTTGCCTTTGATTGGATG

GCCATTCGGTGTCTTCCTCATGAAACAGTTCAGTGAAAATATCCCTACAGAGTTGCTTGAATCAGCTAAAATCGAC

GGTTGTGGTGAGATTCGTACCTTCTGGAGTGTAGCCTTCCCGATTGTGAAACCAGGGTTTGCAGCCCTTGCAATCT

TTACCTTCATCAATACTTGGAATGACTACTTCATGCAATTGGTAATGTTGACTTCACGTAACAATTTGACCATCTCA

CTTGGGGTTGCGACCATGCAGGCTGAAATGGCAACCAACTATGGTTTGATTATGGCAGGAGCTGCCCTTGCTGCTG

TTCCAATCGTCACAGTCTTCCTAGTCTTCCAAAAATCCTTCACACAGGGTATTACTATGGGAGCGGTCAAAGGATA

A

4191.1

ATGAAAAAAACTTTTTTCTTACTGGTGTTAGGCTTGTTTTGCCTTCTTCCACTCTCTGTTTTTGCCATTGATTTCAAG

ATAAACTCTTATCAAGGGGATTTGTATATTCATGCAGACAATACGGCAGAGTTTAGACAGAAGATAGTTTACCAGT

TTGAGGAGGACTTTAAGGGCCAAATCGTGGGACTTGGACGTGCTGGTAAGATGCCTAGCGGGTTTGACATTGACC

CTCATCCAAAGATTCAGGCCGCGAAAAACGGTGCAGAACTAGCAGATGTGACTAGCGAAGTAACAGAAGAAGCG

GATGGTTATACTGTGAGAGTCTATAATCCAGGTCAGGAGGGCGACATAGTTGAAGTTGACCTCGTCTGGAACTTA

AAAAATTTACTTTTCCTTTATGATGATATCGCTGAATTAAATTGGCAACCTCTGACAGATAGTTCAGAGTCTATTG

AAAAGTTTGAATTTCATGTAAGGGGAGACAAGGGGGCTGAAAAACTCTTTTTCCATACAGGGAAACTTTTTAGAG

AGGGAACGATTGAAAAGAGTAACCTTGATTATACTATCCGTTTAGACAATCTTCCGGCTAAGCGTGGAGTTGAGTT

GCATGCCTATTGGCCTCGGACCGATTTTGCTAGCGCTAGGGATCAGGGATTGAAAGGGAATCGTTTAGAAGAGTTT

AATAAGATAGAAGACTCGATTGTTAGAGAAAAAGATCAGAGTAAACAACTCGTTACTTGGGTCCTCCCTTCGATC

CTTTCCATCTCCTTGTTATTGAGTGTCTGCTTCTATTTTATTTATAGAAGAAAGACCACTCCTTCAGTCAAATATGC

CAAAAATCATCGTCTCTATGAACCACCAATGGAATTAGAGCCTATGGTTTTATCAGAAGCAGTCTACTCGACCTCC

TTGGAGGAAGTGAGTCCCTTGGTCAAGGGAGCTGGAAAATTCACCTTTGATCAACTTATTCAAGCTACCTTGCTAG

ATGTGATAGACCGTGGGAATGTCTCTATCATTTCAGAAGGAGATGCAGTTGGTTTGAGGCTAGTAAAAGAAGATG

GTTTGTCAAGCTTTGAGAAAGACTGCCTAAATCTAGCTTTTTCAGGTAAAAAAGAAGAAACTCTTTCCAATTTGTT

TGCGGATTACAAGGTATCTGATAGTCTTTATCGTAGAGCCAAAGTTTCTGATGAAAAACGGATTCAAGCAAGAGG

GCTTCAACTCAAATCTTCTTTTGAAGAGGTATTGAACCAGATGCAAGAAGGAGTGAGAAAACGAGTTTCCTTCTGG

GGGCTCCCAGATTATTATCGTCCTTTAACTGGTGGGGAAAAGGCCTTGCAAGTGGGTATGGGTGCCTTGACTATCC

TGCCCCTATTTATCGGATTTGGTTTGTTCTTGTACAGTTTAGACGTTCATGGCTATCTTTACCTCCCTTTGCCAATA

CTTGGTTTTCTAGGGTTAGTTTTGTCTGTTTTCTATTATTGGAAGCTTCGACTAGATAATCGTGATGGTGTTCTAAA

TGAAGCGGGAGCTGAGGTCTACTATCTCTGGACCAGTTTTGAAAATATGTTGCGTGAGATTGCACGATTGGATCAG

GCTGAACTGGAAAGTATTGTGGTCTGGAATCGCCTCTTGGTCTATGCGACCTTATTTGGCTATGCGGACAAGGTTA

GTCATTTGATGAAGGTTCATCAGATTCAAGTGGAAAATCCAGATATCAATCTCTATGTAGCTTATGGCTGGCACAG

TACGTTTTATCATTCAACAGCACAAATGAGCCATTATGCTAGTGTCGCAAATACAGCAAGCACCTACTCTGTATCT

TCTGGAAGTGGAAGTTCTGGTGGTGGCTTCTCTGGAGGCGGAGGTGGCGGCAGTATCGGTGCCTTTTAA

4191.2

ATGAAAAAAGTAAGAAAGATATTTCAGAAGGCAGTTGCAGGACTGTGCTGTATATCTCAGTTGACAGCTTTTTCTT

CGATAGTTGCTTTAGCAGAAACGCCTGAAACCAGTCCAGCGATAGGAAAAGTAGTGATTAAGGAGACAGGCGAAG

GAGGAGCGCTTCTAGGAGATGCCGTCTTTGAGTTGAAAAACAATACGGATGGCACAACTGTTTCGCAAAGGACAG

AGGCGCAAACAGGAGAAGCGATATTTTCAAACATAAAACCTGGGACATACACCTTGACAGAAGCCCAACCTCCAG

TTGGTTATAAACCCTCTACTAAACAATGGACTGTTGAAGTTGAGAAGAATGGTCGGACGACTGTCCAAGGTGAAC

AGGTAGAAAATCGAGAAGAGGCTCTATCTGACCAGTATCCACAAACAGGGACTTATCCAGATGTTCAAACACCTT

ATCAGATTATTAAGGTAGATGGTTCGGAAAAAAACGGACAGCACAAGGCGTTGAATCCGAATCCATATGAACGTG

TGATTCCAGAAGGTACACTTTCAAAGAGAATTTATCAAGTGAATAATTTGGATGATAACCAATATGGAATCGAATT

GACGGTTAGTGGGAAAACAGTGTATGAACAAAAAGATAAGTCTGTGCCGCTGGATGTCGTTATCTTGCTCGATAA

CTCAAATAGTATGAGTAACATTCGAAACAAGAATGCTCGACGTGCGGAAAGAGCTGGTGAGGCGACACGTTCTCT

TATTGATAAAATTACATCTGATTCAGAAAATAGGGTAGCGCTTGTGACTTATGCTTCCACTATCTTTGATGGGACC

GAGTTTACAGTAGAAAAAGGGGTAGCAGATAAAAACGGAAAGCGATTGAATGATTCTCTTTTTTGGAATTATGAT

CAGACGAGTTTTACAACCAATACCAAAGATTATAGTTATTTAAAGCTGACTAATGATAAGAATGACATTGTAGAAT

TAAAAAATAAGGTACCTACCGAGGCAGAAGACCATGATGGAAATAGATTGATGTACCAATTCGGTGCCACTTTTA

CTCAGAAAGCTTTGATGAAGGCAGATGAGATTTTGACACAACAAGCGAGACAAAATAGTCAAAAAGTCATTTTCC

ATATTACGGATGGTGTCCCAACTATGTCGTATCCGATTAATTTTAATCATGCTACGTTTGCTCCATCATATCAAAAT

CAACTAAATGCATTTTTTAGTAAATCTCCTAATAAAGATGGAATACTATTAAGTGATTTTATTACGCAAGCAACTA

GTGGAGAACATACAATTGTACGCGGAGATGGGCAAAGTTACCAGATGTTTACAGATAAGACAGTTTATGAAAAAG

GTGCTCCTGCAGCTTTCCCAGTTAAACCTGAAAAATATTCTGAAATGAAGGCGGCTGGTTATGCAGTTATAGGCGA

TCCAATTAATGGTGGATATATTTGGCTTAATTGGAGAGAGAGTATTCTGGCTTATCCGTTTAATTCTAATACTGCTA

AAATTACCAATCATGGTGACCCTACAAGATGGTACTATAACGGGAATATTGCTCCTGATGGGTATGATGTCTTTAC

GGTAGGTATTGGTATTAACGGAGATCCTGGTACGGATGAAGCAACGGCTACTAGTTTTATGCAAAGTATTTCTAGT

AAACCTGAAAACTATACCAATGTTACTGACACGACAAAAATATTGGAACAGTTGAATCGTTATTTCCACACCATC

GTAACTGAAAAGAAATCAATTGAGAATGGTACGATTACAGATCCGATGGGTGAGTTAATTGATTTGCAATTGGGC

ACAGATGGAAGATTTGATCCAGCAGATTACACTTTAACTGCAAACGATGGTAGTCGCTTGGAGAATGGACAAGCT

GTAGGTGGTCCACAAAATGATGGTGGTTTGTTAAAAAATGCAAAAGTGCTCTATGATACGACTGAGAAAAGGATT

CGTGTAACAGGTCTGTACCTTGGAACGGATGAAAAAGTTACGTTGACCTACAATGTTCGTTTGAATGATGAGTTTG

TAAGCAATAAATTTTATGATACCAATGGTCGAACAACCTTACATCCTAAGGAAGTAGAACAGAACACAGTGCGCG

ACTTCCCGATTCCTAAGATTCGTGATGTGCGGAAGTATCCAGAAATCACAATTTCAAAAGAGAAAAAACTTGGTG

ACATTGAGTTTATTAAGGTCAATAAAAATGATAAAAAACCACTGAGAGGTGCGGTCTTTAGTCTTCAAAAACAAC

ATCCGGATTATCCAGATATTTATGGAGCTATTGATCAAAATGGCACTTATCAAAATGTGAGAACAGGTGAAGATG

GTAAGTTGACCTTTAAAAATCTGTCAGATGGGAAATATCGATTATTTGAAAATTCTGAACCAGCTGGTTATAAACC

CGTTCAAAATAAGCCTATCGTTGCCTTCCAAATAGTAAATGGAGAAGTCAGAGATGTGACTTCAATCGTTCCACAA

GATATACCAGCGGGTTACGAGTTTACGAATGATAAGCACTATATTACCAATGAACCTATTCCTCCAAAGAGAGAA

TATCCTCGAACTGGTGGTATCGGAATGTTGCCATTCTATCTGATAGGTTGCATGATGATGGGAGGAGTTCTATTAT

ACACACGGAAACATCCGTAA

4191.3

ATGAAATCAATCAACAAATTTTTAACAATGCTTGCTGCCTTATTACTGACAGCGAGTAGCCTGTTTTCAGCTGCAA

CAGTTTTTGCGGCTGGGACGACAACAACATCTGTTACCGTTCATAAACTATTGGCAACAGATGGGGATATGGATA

AAATTGCAAATGAGTTAGAAACAGGTAACTATGCTGGTAATAAAGTGGGTGTTCTACCTGCAAATGCAAAAGAAA

TTGCCGGTGTTATGTTCGTTTGGACAAATACTAATAATGAAATTATTGATGAAAATGGCCAAACTCTAGGAGTGAA

TATTGATCCACAAACATTTAAACTCTCAGGGGCAATGCCGGCAACTGCAATGAAAAAATTAACAGAAGCTGAAGG

AGCTAAATTTAACACGGCAAATTTACCAGCTGCTAAGTATAAAATTTATGAAATTCACAGTTTATCAACTTATGTC

GGTGAAGATGGAGCAACCTTAACAGGTTCTAAAGCAGTTCCAATTGAAATTGAATTACCATTGAACGATGTTGTG

GATGCGCATGTGTATCCAAAAAATACAGAAGCAAAGCCAAAAATTGATAAAGATTTCAAAGGTAAAGCAAATCCA

GATACACCACGTGTAGATAAAGATACACCTGTGAACCACCAAGTTGGAGATGTTGTAGAGTACGAAATTGTTACA

AAAATTCCAGCACTTGCTAATTATGCAACAGCAAACTGGAGCGATAGAATGACTGAAGGTTTGGCATTCAACAAA

GGTACAGTGAAAGTAACTGTTGATGATGTTGCACTTGAAGCAGGTGATTATGCTCTAACAGAAGTAGCAACTGGTT

TTGATTTGAAATTAACAGATGCTGGTTTAGCTAAAGTGAATGACCAAAACGCTGAAAAAACTGTGAAAATCACTT

ATTCGGCAACATTGAATGACAAAGCAATTGTAGAAGTACCAGAATCTAATGATGTAACATTTAACTATGGTAATA

ATCCAGATCACGGGAATACTCCAAAGCCGAATAAGCCAAATGAAAACGGCGATTTGACATTGACCAAGACATGGG

TTGATGCTACAGGTGCACCAATTCCGGCTGGAGCTGAAGCAACGTTCGATTTGGTTAATGCTCAGACTGGTAAAGT

TGTACAAACTGTAACTTTGACAACAGACAAAAATACAGTTACTGTTAACGGATTGGATAAAAATACAGAATATAA

ATTCGTTGAACGTAGTATAAAAGGGTATTCAGCAGATTATCAAGAAATCACTACAGCTGGAGAAATTGCTGTCAA

GAACTGGAAAGACGAAAATCCAAAACCACTTGATCCAACAGAGCCAAAAGTTGTTACATATGGTAAAAAGTTTGT

CAAAGTTAATGATAAAGATAATCGTTTAGCTGGGGCAGAATTTGTAATTGCAAATGCTGATAATGCTGGTCAATAT

TTAGCACGTAAAGCAGATAAAGTGAGTCAAGAAGAGAAGCAGTTGGTTGTTACAACAAAGGATGCTTTAGATAGA

GCAGTTGCTGCTTATAACGCTCTTACTGCACAACAACAAACTCAGCAAGAAAAAGAGAAAGTTGACAAAGCTCAA

GCTGCTTATAATGCTGCTGTGATTGCTGCCAACAATGCATTTGAATGGGTGGCAGATAAGGACAATGAAAATGTTG

TGAAATTAGTTTCTGATGCACAAGGTCGCTTTGAAATTACAGGCCTTCTTGCAGGTACATATTACTTAGAAGAAAC

AAAACAGCCTGCTGGTTATGCATTACTAACTAGCCGTCAGAAATTTGAAGTCACTGCAACTTCTTATTCAGCGACT

GGACAAGGCATTGAGTATACTGCTGGTTCAGGTAAAGATGACGCTACAAAAGTAGTCAACAAAAAAATCACTATC

CCACAAACGGGTGGTATTGGTACAATTATCTTTGCTGTAGCGGGGGCTGCGATTATGGGTATTGCAGTGTACGCAT

ATGTTAAAAACAACAAAGATGAGGATCAACTTGCTTAA

4191.4

ATGACAATGCAGAAAATGCAGAAAATGATTAGTCGTATCTTCTTTGTTATGGCTCTGTGTTTTTCTCTTGTATGGGG

TGCACATGCAGTCCAAGCGCAAGAAGATCACACGTTGGTCTTGCAATTGGAGAACTATCAGGAGGTGGTTAGTCA

ATTGCCATCTCGTGATGGTCATCGGTTGCAAGTATGGAAGTTGGATGATTCGTATTCCTATGATGATCGGGTGCAA

ATTGTAAGAGACTTGCATTCGTGGGATGAGAATAAACTTTCTTCTTTCAAAAAGACTTCGTTTGAGATGACCTTCC

TTGAGAATCAGATTGAAGTATCTCATATTCCAAATGGTCTTTACTATGTTCGCTCTATTATCCAGACGGATGCGGT

TTCTTATCCAGCTGAATTTCTTTTTGAAATGACAGATCAAACGGTAGAGCCTTTGGTCATTGTAGCGAAAAAAACA

GATACAATGACAACAAAGGTGAAGCTGATAAAGGTGGATCAAGACCACAATCGCTTGGAGGGTGTCGGCTTTAAA

TTGGTATCAGTAGCAAGAGATGTTTCTGAAAAAGAGGTTCCCTTGATTGGAGAATACCGTTACAGTTCTTCTGGTC

AAGTAGGGAGAACTCTCTATACTGATAAAAATGGAGAGATTTTTGTGACAAATCTTCCTCTTGGGAACTATCGTTT

CAAGGAGGTGGAGCCACTGGCAGGCTATGCTGTTACGACGCTGGATACGGATGTCCAGCTGGTAGATCATCAGCT

GGTGACGATTACGGTTGTCAATCAGAAATTACCACGTGGCAATGTTGACTTTATGAAGGTGGATGGTCGGACCAA

TACCTCTCTTCAAGGGGCAATGTTCAAAGTCATGAAAGAAGAAAGCGGACACTATACTCCTGTTCTTCAAAATGGT

AAGGAAGTAGTTGTAACATCAGGGAAAGATGGTCGTTTCCGAGTGGAAGGTCTAGAGTATGGGACATACTATTTA

TGGGAGCTCCAAGCTCCAACTGGTTATGTTCAATTAACATCGCCTGTTTCCTTTACAATCGGGAAAGATACTCGTA

AGGAACTGGTAACAGTGGTTAAAAATAACAAGCGACCACGGATTGATGTGCCAGATACAGGGGAAGAAACCCTTG

TATATCTTGATGCTTGTTGCCATTTTGTTGTTTGGTAG

4191.5

ATGAGCCACATATACTTATCTATTTTCACAAGTCTCTTGCTGATGCTAGGACTTGTCAATGTTGCTCAAGCCGATG

AATATTTACGCATCGGTATGGAAGCAGCATATGCTCCCTTTAACTGGACCCAGGATGATGATAGCAACGGAGCTG

TCAAAATCGATGGGACCAATCAGTATGCCAACGGATACGATGTTCAAATCGCCAAGAAAATCGCTAAGGACTTAG

GTAAAGAACCTTTGGTTGTTAAAACCAAGTGGGAAGGTCTAGTCCCTGCCCTTACTTCTGGTAAGATTGACATGAT

TATCGCAGGTATGAGTCCAACTGCAGAACGCAAACAAGAAATTGCCTTTTCGAGCAGTTACTATACTAGCGAACC

AGTTTTGCTTGTCAAAAAAGATTCTGCCTACGCAAGTGCTAAATCTTTGGATGACTTTAACGGTGCAAAAATCACT

TCTCAACAAGGGGTCTACCTTTATAACTTGATTGCACAAATCCCAGGTGCTAAAAAAGAAACAGCCATGGGAGAC

TTCGCTCAAATGCGACAAGCTCTTGAGGCTGGTGTCATTGATGCTTATGTTTCTGAACGTCCAGAAGCACTGACTG

CTGAAGCTGCGAACTCTAAGTTCAAGATGATTCAAGTAGAACCTGGTTTCAAAACTGGGGAAGAAGATACAGCTA

TCGCTATCGGGCTTCGTAAAAATGACAATCGTATTAGCCAAATCAATGCCAGCATTGAAACCATTTCAAAAGATG

ACCAAGTTGCCTTGATGGATCGTATGATCAAGGAACAACCTGCCGAAGCTACAACAACTGAAGAGACTAGCAGTA

GTTTCTTTAGCCAAGTTGCTAAAATTCTTTCTGAAAACTGGCAACAACTCTTGCGTGGTGCTGGTATCACTCTTTTA

ATCTCTATCGTCGGAACCATCATAGGTCTCATTATTGGACTTGCCATTGGTGTCTTCCGTACTGCTCCTCTCTCTGA

AAACAAAGTCATTTACGGCCTACAAAAACTAGTCGGCTGGGTTCTCAATGTCTACATTGAAATTTTCCGTGGTACG

CCAATGATTGTTCAATCGATGGTTATCTACTATGGAACTGCCCAAGCTTTCGGGATCAACC

TTGACCGTACACTGGCTGCTATCTTCATCGTTTCAATCAATACCGGTGCCTACATGACTGAAATCGTCCGTGGTGG

TATCCTAGCAGTTGACAAGGGACAATTTGAAGCTGCGACTGCTCTTGGTATGACCCATAACCAGACCATGCGTAA

GATTGTCCTACCTCAGGTAGTCCGTAACATCCTACCTGCAACTGGTAATGAATTTGTCATCAATATCAAAGATACA

TCTGTATTGAACGTTATCTCTGTTGTCGAACTTTATTTCTCAGGAAATACCGTGGCAACACAAACCTATCAATACTT

CCAGACATTTACAATCATCGCCGTGATTTACTTTGTCCTCACCTTCACCGTAACACGTATCCTACGCTTTATCGAGC

GCAGAATGGACATGGATACCTACACTACAGGTGCTAACCAAATGCAAACGGAGGATTTGAAATAA

4191.6

ATGACACAAGCAATCCTTGAAATTAAACACCTCAAAAAATCCTATGGACAAAACGAAGTGCTAAAAGACATTTCA

CTCACTGTCCACAAGGGAGAGGTCATCTCTATCATCGGAAGCTCTGGAAGCGGAAAATCGACCTTCCTACGCTCC

ATTAACCTACTTGAAACACCAACTGATGGACAAATCCTTTATCATGGACAAAACGTCCTCGAAAAAGGCTATGAC

CTCACGCAATACCGTGAAAAGTTGGGGATGGTTTTCCAATCCTTTAACCTCTTTGAAAATCTCAATGTTCTTGAAA

ACACAATCGTCGCTCAGACAACTGTCCTAAAACGCGAACGCACAGAAGCTGAAAAGATTGCCAAAGAAAACCTG

GAAAAGGTCGGCATGGGAGAACGCTACTGGCAAGCCAAACCAAAACAACTCTCAGGTGGTCAAAAACAACGTGT

GGCCATCGCTCGTGCCCTCTCCATGAATCCGGACGCTATTCTCTTTGATGAACCAACATCAGCTCTCGATCCAGAA

ATGGTTGGAGAAGTCCTCAAAATCATGCAGGACCTGGCTCAGGAAGGCTTGACCATGATTGTCGTAACCCATGAA

ATGGAATTTGCCCGTGATGTCTCTCACCGTGTTATCTTTATGGATAAGGGCGTGATCGCTGAAGAAGGTAAACCAG

AAGACCTCTTCACCAATCCTAAAGAAGACCGAACAAAAGAGTTCCTTCAACGCTATCTCAAATAA

4192.3

ATGAAAAAGTATCAACTTCTATTCAAAATAAGTGCAGTCTTCTCTTACTTATTTTTCGTATTTAGTCTTTCTCAGCT

GACGCTTATCGTCCAAAACTATTGGCAATTTTCTTCTCAGATAGGCAATTTATTCTGGATTCAAAATATCTTGAGTT

TACTTTTTATTGGAGTCATGATTGTGGTTCTTGTTAAGACAGGCCATGGTTATCTCTTCCGCATTCCAAGAAAAAA

ATGGCTTTGGTATTCGATTTTGACAGTATTAGTGCTAGTGTTCCAGATCTCTTTTAACGTTCAGACAGCTAAACATG

TTCAGTCAACTGCGGAAGGTTGGGCTGTATTGATTGGTTATAGTGGGACTAACTTTGCAGAGCTAGGTATTTATAT

AGCCCTGTTCTTTCTGGTTCCACTGATGGAAGAATTGATTTATAGAGGATTACTGCAACATGCTTTCTTTAAGCATT

CGCGATTTGGTCTTGATTTGCTTCTTCCTTCTATTTTATTTGCTCTCCCTCATTTTTCAAGCCTGCCTAGTCTGTTAG

ATATCTTCGTCTTTGCAACAGTTGGAATCATCTTTGCTGGTTTGACCCGCTATACCAAGAGCATTTATCCATCCTAT

GCGGTGCATGTGATCAATAATATTGTAGCGACCTTCCCGTTTTTGCTCACTTTTCTACATAGGGTCTTGGGGTAA

4193.1

ATGAACAAGAAACAATGGCTAGGTCTTGGCCTAGTTGCAGTGGCAGCAGTTGGACTTGCTGCATGTGGTAACCGC

TCTTCTCGTAACGCAGCTTCATCTTCTGATGTGAAGACAAAAGCAGCAATCGTCACTGATACTGGTGGTGTTGATG

ACAAATCATTCAACCAATCAGCTTGGGAAGGTTTGCAGGCTTGGGGTAAAGAACACAATCTTTCAAAAGATAACG

GTTTCACTTACTTCCAATCAACAAGTGAAGCTGACTACGCTAACAACTTGCAACAAGCGGCTGGAAGTTACAACCT

AATCTTCGGTGTTGGTTTTGCCCTTAATAATGCAGTTAAAGATGCAGCAAAAGAACACACTGACTTGAACTATGTC

TTGATTGATGATGTGATTAAAGACCAAAAGAATGTTGCGAGCGTAACTTTCGCTGATAATGAGTCAGGTTACcTTG

CAGGTGTGGCTGCAGCAAAAACAACTAAGACAAAACAAGTTGGTTTTGTAGGTGGTATCGAATCTGAAGTTATCT

CTCGTTTTGAAGCAGGATTCAAGGCTGGTGTTGCGTCAGTAGACCCATCTATCAAAGTCCAAGTTGACTACGCTGG

TTCATTTGGTGATGCGGCTAAAGGTAAAACAATTGCAGCCGCACAATACGCAGCCGGTGCAGATATTGTTTACCA

AGTAGCTGGTGGTACAGGTGCAGGTGTCTTTGCAGAGGCAAAATCTCTCAACGAAAGCCGTCCTGAAAATGAAAA

AGTTTGGGTTATCGGTGTTGATCGTGACCAAGAAGCAGAAGGTAAATACACTTCTAAAGATGGCAAAGAATCAAA

CTTTGTTCTTGTATCTACTTTGAAACAAGTTGGTACAACTGTAAAAGATATTTCTAACAAGGCAGAAAGAGGAGAA

TTCCCTGGCGGTCAAGTGATCGTTTACTCATTGAAGGATAAAGGGGTTGACTTGGCAGTAACAAACCTTTCAGAAG

AAGGTAAAAAAGCTGTCGAAGATGCAAAAGCTAAAATCCTTGATGGAAGCGTAAAAGT

TCCTGAAAAATAA

4193.3

ATGTCTAAAAAATTACAACAAATTTCGGTTCCCTTGATTTCTGTATTCCTAGGAATTTTACTCGGAGCCATTGTCAT

GTGGATCTTCGGTTATGATGCTATTTGGGGCTACGAAGAATTGTTCTATACAGCCTTTGGCAGTCTGCGTGGGATT

GGAGAAATCTTCCGTGCTATGGGTCCTCTGGTCTTGATTGGTCTTGGTTTTGCCGTTGCCAGTCGAGCTGGTTTCTT

TAACGTCGGACTTCCTGGTCAGGCTTTGGCAGGTTGGATTCTCAGTGGTTGGTTTGCCCTGTCGCATCCAGATATG

CCCCGTCCCTTGATGATTCTAGCAACCATCGTGATTGCCTTGATTGCTGGTGGGATTGTCGGAGCGATTCCAGGTA

TTCTTAGGGCCTATCTAGGGACGTCAGAGGTTATTGTAACCATCATGATGAACTACATTGTCTTGTATGTAGGGAA

TGCCTTTATCCATGCTTTCCCTAAAGACTTCATGCAAAGTACAGATTCGACCATTCGTGTTGGGGCTAATGCAACC

TATCAGACACCTTGGTTGGCTGAGTTGACTGGTAACTCACGGATGAATATTGGTATTTTCTTTGCCATCATTGCCGT

TGCAGTTATTTGGTTCATGCTCAAGAAAACAACTCTTGGTTTTGAAATCCGTGCAGTTGGTCTTAATCCACATGCTT

CAGAATATGCTGGTATTTCTGCCAAGCGGACTATTATCCTATCTATGATTATTTCAGGTGCCTTGGCAGGTCTTGGT

GGAGCTGTTGAAGGTTTGGGAACCTTCCAGAACGTCTATGTTCAAGGTTCGTCATTAGCTATCGGATTTAACGGAA

TGGCGGTTAGTTTGCTTGCGGCCAACTCACCAATTGGTATACTCTTTGCAGCCTTCCTATTTGGCGTTCTCCAAGTT

GGGGCTCCTGGTATGAATGCGGCGCAGGTACCATCTGAGCTTGTCAGCATTGTAACAGCGTCTATTATCTTCTTTG

TCAGTGTTCATTACCTTATCGAACGCTTTGTCAAACCGAAAAAACAAGTTAAAGGAGGTAAGTAA

4194.1

ATGGGAGTGAAAAAGAAACTAAAGTTGACTAGTTTGCTAGGACTGTCTCTGTTAATCATGACAGCCTGTGCGACT

AATGGGGTAACTAGCGATATTACAGCCGAATCGGCTGATTTTTGGAGTAAATTGGTTTACTTCTTTGCGGAAATCA

TTCGCTTTTTATCGTTTGATATTAGTATCGGAGTGGGGATTATTCTCTTTACGGTCTTGATTCGTACAGTCCTCTTG

CCAGTCTTTCAGGTGCAAATGGTGGCTTCTAGGAAAATGCAGGAAGCTCAGCCACGCATTAAGGCGCTTCGAGAA

CAATATCCAGGTCGAGATATGGAAAGCAGAACCAAACTAGAGCAGGAAATGCGTAAAGTATTTAAAGAAATGGG

TGTCAGACAGTCAGACTCTCTTTGGCCGATTTTGATTCAGATGCCGGTTATTTTGGCCCTGTTCCAAGCCCTATCAA

GAGTTGACTTTTTAAAGACAGGTCATTTCTTATGGATTAACCTTGGTAGTGTGGATACAACCCTTGTTCTTCCGATT

TTAGCAGCAGTATTCACCTTTTTAAGTACTTGGTTGTCCAACAAAGCTTTGTCTGAGCGAAATGGCGCTACGACTG

CGATGATGTATGGGATTCCAGTCTTGATTTTTATCTTTGCAGTTTATGCGCCAGGTGGAGTCGCCCTATACTGGAC

AGTGTCTAATGCTTATCAAGTCTTGCAAACCTATTTCTTGAATAATCCATTCAAGATTATCGCAGAGCGCGAGGCC

GTAGTACAGGCACAAAAAGATTTGGAAAATAGAAAAAGAAAAGCCAAGAAAAAGGCTCAGAAAACGAAATAA

4194.4

ATGGTTATCGATCCATTTGCTATCAACGAACTAGACTATTACTTAGTTTCACACTTCCACAGTGATCATATCGACC

CATACACAGCTGCAGCAATTCTCAATAATCCTAAGTTAGAGCATGTTAAGTTTATCGGTCCTTACCACTGTGGACG

AATCTGGGAAGGATGGGGTGTTCCAAAAGAACGTATCATCGTTGTTAAACCAGGTGACACTATCGAATTAAAAGA

TATGAAGATTCATGCAGTAGAATCATTTGACCGTACTTGCTTGGTAACTCTCCCAGTGAACGGTGCTGATGAGACA

GGCGGTGAACTTGCTGGCTTGGCTGTTACAGATGAAGAAATGGCTCAAAAGGCTGTTAACTATATCTTTGAAACAC

CAGGTGGAACCATCTATCATGGTGCAGATTCTCACTTCTCAAACTATTTTGCAAAACATGGTAAAGACTTTAAAAT

TGATGTTGCTTTGAATAACTATGGTGAAAATCCGGTAGGTATCCAAGACAAAATGACATCTATCGACCTTCTTCGT

ATGGCAGAAAATCTGCGTACCAAAGTCATTATCCCAGTTCACTATGATATCTGGTCTAACTTCATGGCTTCTACTA

ATGAGATTCTAGAACTTTGGAAAATGCGAAAAGATCGCTTGCAATACGATTTCCATCCATTTATCTGGGAAGTTGG

CGGTAAGTACACTTATCCTCAAGATCAACACTTAGTAGAATACCATCATCCACGTGGTTTTGATGATTGTTTTGAA

CAAGACTCTAACATTCAATTTAAAGCTTTGCTATAA

4196.2

ATGTTCCTTTCAGGCTGGTTGTCTAGTTTTGCTAATACTTATATCCATGATTTACTGGGGGTTCTTTTCCCAGATAG

TCCATTTTTAAATGCCTTTGAAAGTGCTATTGCGGCTCCTTTGGTAGAAGAACCCTTGAAATTATTGTCACTTGTTT

TTGTTTTGGCTTTGATTCCTGTGCGAAAATTAAAATCTTTGTTTTTACTTGGAATTGCTTCCGGTTTGGGATTCCAA

ATGATTAAGGATATTGGTTATATTCGTACGGATTTGCCAGAGGGCTTTGACTTTACTATTTCGCGAATTTTAGAGC

GTATCATCTCAGGAATTGCCTCTCACTGGACTTTTTCAGGTCTAGCTGTAGTAGGTGTTTACTTGCTTTACAGAGCC

TATAAAGGACAGAAGGTTGGCAAGAAACAGGGCCTTATTTTTCTAGGTTTAGCCTTGGGAACTCACTTCTTGTTTA

ACTCTCCTTTTGTGGAGTTGGAAACAGAGTTGCCTTTAGCGATTCCAGTGGTTACGGCTATTGCTCTCTATGGTTTT

TATCATGCTTATTGCTTTGTTGAGAAACACAATGAGTTGATGACCTAG

4197.1

ATGAAGGTGGAACCACGTTGCGACGTCCTTTCGAGGATGTCGCATTTTTTTATTAGGATACTAAT?TATGGAGTTGC

AAGAATTAGTGGAGCGCAGTTGGGCAATCCGACAAGCTTATCACGAACTGGAAGTTAAGCATCATGATTCCAAGT

GGACGGTAGAAGAAGACCTCTTGGCTTTATCTAATGATATTGGAAATTTCCAACGACTGGTGATGACAAAGCAAG

GACGCTACTATGATGAAACACCCTACACACTGGAACAAAAACTTTCAGAAAATATCTGGTGGCTATTAGAACTTT

CTCAACGTTTGGATATAGACATTCTGACGGAAATGGAAAACTTCCTCTCTGATAAAGAAAAGCAATTGAACGTTA

GGACTTGGAAGTAG

4197.4

ATGCTTGATTGGAAACAATTTTTTCTAGCCTATCTGCGCTCCCGTAGTCGTCTTTTTATCTATCTGCTTTCTTTGGC

ATTTCTTGTCTTACTCTTTCAGTTTTTATTTGCCAGTCTAGGAATTTACTTCCTCTACTTTTTCTTCTTGTGTTGCTTT

GTAACCATATTATTTTTCACTTGGGACATATTGGTGGAAACGCAGGTCTATCGCCAGGAACTTCTCTATGGAGAGA

GGGAAGCCAAGTCTCCTTTGGAAATAGCTTTAGCAGAAAAATTAGAAGCGCGTGAGATGGAACTCTATCAGCAGA

GGTCAAAAGCAGAAAGAAAACTGACGGATTTGCTGGATTACTATACCTTGTGGGTCCATCAGATAAAGACCCCCA

TTGCAGCCAGTCAACTCTTAGTTGCAGAAGTGGTCGACCGCCAACTGAAGCAGCAGCTAGAACAGGAAATTTTCA

AAATCGACTCCTATACCAACCTAGTTTTACAGTACCTGCGTTTAGAAAGTTTCCATGATGATTTGGTCTTAAAGCA

GGTTCAAATTGAGGACTTGGTCAAGGAAATAATTCGTAAATATGCTTTTTCTTTATTCAAAAAGGCTTAAATGTC

AATCTACATGACCTTGATAAAGAAATCGTGACGGATAAAAAGTGGCTGCTAGTGGTTATTGAGCAAATCATCTCA

AACAGTCTCAAGTACACCAAGGAAGGTGGTCTGGAGATTTATATGGATGACCAAGAGCTTTGTATCAAAGATACG

GGAATCGGGATAAAAAACAGTGATGTCCTCCGAGTATTTGAACGTGGCTTTTCAGGATACAATGGCCGTTTGACCC

AGCAGTCCTCTGGACTTGGCCTTTATCTATCTAAGAAAATTTCTGAAGAACTGGGGCACCAGATTCGTATCGAGTC

TGAGGTCGGAAAAGGAACGACAGTGCGGATTCAGTTTGCTCAAGTGAACTTAGTCCTTGAGTAA

4211.2

ATGGAACTTAATACACACAATGCTGAAATCTTGCTCAGTGCAGCTAATAAGTCCCACTATCCGCAGGATGAACTG

CCAGAGATTGCCCTAGCAGGGCGTTCAAATGTTGGTAAATCCAGCTTTATCAACACTATGTTGAACCGTAAGAATC

TCGCCCGTACATCAGGAAAACCTGGTAAAACCCAGCTCCTGAACTTTTTTAACATTGATGACAAGATGCGCTTTGT

GGATGTGCCTGGTTATGGCTATGCTCGTGTTTCTAAAAAGGAACGTGAAAAGTGGGGGTGCATGATTGAGGAGTA

CTTAACGACTCGGGAAAATCTCCGTGCGGTTGTCAGTCTAGTTGACCTTCGTCATGACCCGTCAGCAGATGATGTG

CAGATGTACGAATTTCTCAAGTATTATGAGATTCCAGTCATCATTGTGGCGACCAAGGCGGACAAGATTCCTCGTG

GTAAATGGAACAAGCATGAATCAGCAATCAAAAAGAAATTAAACTTTGACCCGAGTGACGATTTCATCCTCTTTTC

ATCTGTCAGTAAGGCAGGGATGGATGAGGCTTGGGATGCAATCTTAGAAAAATTGTGA

4211.3

ATGACAAAGAAACAACTTCACTTGGTGATTGTGACAGGGATGAGTGGCGCAGGGAAAACTGTAGCCATTCAGTCC

TTCGAGGATCTAGGTTATTTCACCATTGATAATATGCCGCCAGCTCTCTTGCCTAAGTTTTTGCAGCTGGTTGAAAT

TAAGGAAGACAATCCTAAGTTGGCCTTGGTAGTGGATATGCGTAGCCGTTCTTTCTTTTCAGAGATTCAAGCTGTT

TTGGATGAGTTGGAAAATCAAGATGGTTTGGATTTCAAAATCCTCTTTTTGGATGCGGCTGATAAGGAATTGGTCG

CTCGTTACAAGGAAACCAGACGGAGTCACCCACTAGCAGCAGACGGTCGTATTTTAGATGGAATCAAGTTGGAAC

GTGAACTCTTGGCACCTTTGAAAAATATGAGCCAAAATGTGGTGGATACGACTGAACTCACTCCACGTGAGcTGCG

CAAAACCCTTGCAGAGCAGTTTTCAGACCAAGAACAAGCCCAGTCTTTCCGTATCGAAGTCATGTCTTTCGGATTT

AAGTATGGAATCCCGATTGATGCGGACTTGGTCTTTGATGTCCGTTTCTTGCCAAATCCCTATTATTTACCAGAACT

GAGAAACCAAACGGGTGTGGATGAACCTGTTTATGATTATGTCATGAACCATCCTGAGTCAGAAGACTTTTATCAA

CATTTATTGGCCTTGATTGAGCCGATTCTGCCAAGTTACCAAAAGGAAGGTAAGTCCGTTTTGACCATTGCCATGG

GATGTACGGGTGGACAACACCGTAGTGTGGCATTTGCTAAACGCTTGGCGCAGGACTTATCCAAGAATTGGTCTGT

TAATGAAGGGCATCGCGACAAAGACCGCAGAAAGGAAACGGTAAACCGTTCATGA

4211.4

ATGAGAAAACCAAAGATAACGGTGATTGGTGGAGGGACTGGAAGTCCCGTCATTCTAAAAAGTCTGCGGGAAAAA

GATGTGGAAATCGCAGCTATCGTGACGGTGGCAGATGATGGTGGTTCTTCAGGTGAACTCCGAAAAAATATGCAA

CAGTTGACACCGCCAGGTGATCTTCGTAATGTCCTTGTGGCCATGTCGGATATGCCTAAGTTTTATGAGAAGGTCT

TTCAGTATCGGTTCTCTGAGGATGCCGGAGCCTTTGCTGGCCATCCATTGGGAAATCTCATCATTGCTGGCTTGTC

AGAAATGCAGGGTTCAACCTATAATGCCATGCAGTTATTGAGCAAATTTTTCCATACAACAGGGAAAATTTATCCT

TCCAGTGACCATCCTTTGACCCTTCATGCAGTCTTTCAGGATGGGACAGAAGTGGCTGGAGAGAGTCATATTGTAG

ACCATCGAGGCATAATTGACAATGTCTATGTGACCAATGCCCTAAACGATGATACGCCTCTGGCCAGCCGTCGAG

TAGTGCAGACCATCCTTGAAAGTGACATGATTGTCCTAGGGCCAGGTTCCCTCTTTACCTCTATTTTGCCCAATAT

CGTGATTAAGGAAATTGGGCGGGCTCTTTTGGAAACCAAGGCAGAAATTGCCTATGTCTGCAATATCATGACCCA

ACGTGGGGAGACGGAACACTTTACAGATAGCGACCACGTGGAAGTCTTGCATCG?TCACCTTGGTCGCCCTTTTATC

GACACTGTCTTGGTGAATATTGAAAAAGTGCCTCAGGAATACATGAATTCCAACCGTTTTGATGAATACTTAGTGC

AAGTGGAACACGATTTTGTAGGTCTTTGTAAGCAAGTTTCGCGCGTGATTTCATCTAACTTCCTTCGTCTGGAAAA

TGGCGGTGCCTTCCACGATGGAGATTTGATTGTGGACGAGTTGATGCGCATTATACAGGTGAAAAAATGA

4213.1

ATGAAAAATTTGATAAAGTTGCTAATAATTAGATTGATTGTTAACTTAGCAGACAGTGTATTTTATATAGTAGCAT

TGTGGCACGTTAGCAATAATTATTCTTCGAGCATGTTCTTAGGAATATTTATTGCAGTAAATTATCTACCGGATTTG

TTACTAATCTTTTTTGGACCAGTTATTGACAGAGTAAATCCGCAAAAAATTCTTATAATATCAATTTTGGTTCAATT

AGCAGTGGCTGTAATATTTTTATTATTATTAAACCAAATATCATTTTGGGTGATAATGAGTCTAGTGTTTATTTCAG

TAATGGCTAGCTCCATAAGTTACGTGATAGAAGATGTGTTGATTCCTCAAGTGGTAGAATATGATAAGATTGTATT

TGCAAATTCTCTTTTTAGTATTTCGTATAAAGTATTAGATTCTATTTTTAATTCATTCGCATCATTTTTACAGGTGG

CAGTAGGATTTATTTTATTGGTTAAGATAGATATAGGCATATTTTTACTTGCTCTATTTATATTGTTGTTGTTAAAA

TTTAGAACTAGCAATGCGAATATAGAAAACTTCTCTTTCAAATATTACAAGAGAGAAGTGTTGCAAGGTACAAAG

TTTATTTTAAATAATAAATTATTATTTAAAACCAGTATTTCTTTAACGCTTATAAACTTTTTTTATTCATTTCAGACA

GTAGTTGTACCGATTTTTTCTATTCGATATTTTGATGGTCCGATTTTTTATGGTATTTTTTTAACTATTGCTGGTTTG

GGTGGTATATTGGGAAATATGCTAGCGCCAATCGTAATAAAATATTTAAAATCGAATCAAATTGTTGGTGTATTTC

TTTTTTTTGAACGGCTCAAGTTGGTTAGTAGCAATTGTTATAAAAGACTATACTTTATCACTTATTTTATTTTTCGTTT

GTTTTATGTCTAAAGGAGTCTTCAATATTATTTTTAATTCGTTGTACCAACAAATACCTCCACATCAACTTCTTGGT

AGGGTAAATACTACCATTGATTCTATTATTTCTTTTGGAATGCCAATTGGTAGTTTAGTTGCAGGAACGCTTATTGA

TTTGAATATTGAATTAGTGTTAATTGCTATTAGCATACCTTATTTTTTTGTTTTCTTATATTTTTTATACGGATAATGG

ATTGAAAGAATTTAGTATATATTAG

4213.2

ATGATGTCTAACAAAAATAAGGAAATTCTGATTTTTGCGATTCTCTATACAGTCCTCTTTATGTTTGATGGCGTTAA

ATTGCTGGCTTCTTTAATGCCATCTGCCATTGCAAATTATCTTGTTTATGTAGTTTTAGCTCTATATGGCTCCTTCTT

GTTCAAGGATAGATTGATCCAACAATGGAAGGAGATTAGAAAGACTAAAAGAAAATTCTTCTTTGGAGTCTTAAC

AGGATGGCTCTTTCTCATTCTGATGACTGTTGTCTTTGAATTTGTATCAGAGATGTTGAAGCAGTTTGTGGGACTAG

ATGGACAAGGTCTAAATCAGTCTAATATTCAAAGTACCTTTCAAGAACAACCACTACTGATAGCTGTTTTTGCTTG

TGTCATTGGACCTCTGGTAGAAGAATTATTTTTCCGTCAGGTCTTATTGCATTACTTGCAGGAACGGTTGTCAGGTT

TACTAAGCATTATTCTGGTAGGACTTGTTTTTGCTCTGACTCATATGCACAGTTTGGCTCTATCAGAGTGGATTGGT

GCAGTTGGTTACTTAGGTGGAGGCCTTGCCTTTTCTATTATTTATGTGAAAGAAAAAGAGAATATCTACTATCCCC

TACTTGTTCACATGTTAAGCAACAGCCTCTCCTTAATCATTTTAGCTATCAGTATAGTAAAATGA

4224.1

TTGAAAAAGCCAATTATCGAATTCAAAAACGTCTCTAAAGTTTTTGAAGACAGCAACACCAAGGTTCTCAAAGAC

ATCAACTTTGAGTTGGAAGAAGGGAAATTCTACACCCTTCTAGGTGCATCTGGTTCGGGGAAATCAACTATCCTAA

ACATTATTGCAGGTTTACTGGATGCGACGACAGGAGATATCATGCTAGACGGTGTTCGTATCAATGATATTCCAAC

CAACAAGCGCGACGTACATACCGTCTTCCAATCCTATGCCTTGTTCCCACATATGAATGTGTTTGAAAATGTTGCC

TTTCCACTTCGCTTGCGTAAAATTGATAAGAAAGAAATCGAGCAGCGTGTAGCGGAAGTTCTCAAGATGGTTCAGT

TGGAAGGTTATGAAAAACGTTCCATCCGCAAACTTTCTGGAGGACAACGTCAGCGTGTGGCCATCGCCCGTGCTA

TCATCAACCAACCCCGTGTGGTCTTGTTGGACGAGCCTTTATCAGCGCTGGACTTGAAATTGAGAACAGACATGCA

GTACGAATTGCGTGAATTACAACAACGATTGGGCATTACCTTTGTCTTTGTCACTCACGATCAGGAAGAAGCTCTT

GCCATGAGTGACTGGATTTTCGTTATGAATGATGGCGAGATTGTCCAGTCTGGAACCCCTGTGGACATCTACGATG

AGCCAATCAACCACTTTGTTGCCACCTTTATCGGGGAGTCAAACATCTTGCCAGGTACCATGATTGAGGACTACTT

GGTCGAATTTAACGGCAAACGCTTTGAAGCGGTTGATGGTGGGATGAAGCCAAATGAACCTGTTGAGGTCGTTAT

TCGTCCAGAGGACTTGCGCATTACCCTTCCTGAAGAAGGCAAGCTCCAAGTTAAGGTCGATACCCAGCTTTTCCGT

GGAGTTCATTATGAAATTATCGCCTATGACGAACTTGGAAATGAATGGATGATCCACTCAACCCGTAAGGCTATCG

TGGGTGAGGAAATCGGTCTGGACTTTGAACCAGAAGACATCCACATCATGCGTCTCAATGAAACCGAAGAAGAGT

TCGATGCTCGTATTGAGGAGTACGTAGAAATCGAAGAGCAAGAAGCAGGTTTGATCAATGCAATCGAGGAGGAAA

GAGATGAAGAAAACAAGCTCTAA

4252.1

ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAAT

GCATCTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTCGTTTCAGGAATCTGTGCTGGAGT

AAATTATCTTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGT

ATGTTACTCTTAATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCA

AGAATTAGTTGACTTTTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAA

ATACGTGCGCGATTTTCTTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTC

TTAAGAAATCCAATGACCATTGTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCC

AAATTCGGTTAAGAAGGAAGTTTCCTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTT

TCTTTTAG

4252.2

ATGGTTAAAAAAATTATTGGAATGGTGCTAGCTTTACTTTCTGTAACTGTAGTAGGAGTAGGTGTTTTTGCTTATAC

TATTTATCAACAAGGGACAGAAACCTTAGCTAAAACCTATAAAAAAATCGGTGAAGAAACCAAGGTTATTGAAGC

GACTGAACCTCTAACCATTCTGTTAATGGGAGTGGACACCGGAAATGTTGAACGAACTGAAACTTGGGTCGGTAG

AAGTGATAGCATGATCTTGATGACAGTGAATCCTAAAACGAAAAAAACAACAATGATGAGTTTAGAGCGGGATAT

TCTGACGCGCATTGAATCAGGGAATGGTCAGGCTCATGAAGCGAAACTGAACTCAGCATATGCAGATGGTGGAGC

AGAGCTTGCTATAGAAACCATTCAAAAAATGATGAATATCCATATTGATCGCTATGTGATGGTCAATATGAGAGG

ATTGCAAAAACTAGTGGATGCAGTAGGAGGTATTACAGTCAATAATATCCTAGGTTTCCCAATTTCTATCAGTGAC

CAAGAAGAATTTAATACTATTTCTATCGGTGTTGGGGAGCAACATATTGGGGGAGAAGAAGCCCTAGTCTATGCA

CGAATGCGTTACCAAGATCCTGAGGGGGATTATGGTCGTCAAAAACGTCAACGTGAAGTTATTCAAAAAGTCATG

GAAAAAGCTCTCAGTTTAAATAGCATTGGTCATTATCAAGAGATTCTAAAAGCTTTGAGTGACAATATGCAGACC

AATATTGATTTGTCTGCAAAAAGTATCCCTAACTTGCTAGGCTATAAAGATTCATTTAAAACCATTGAAACTCAGC

AGTTGCAGGGTGAAGGAGAGATACTTCAAGGTGTTTCTTACCAGATTGTTTCGAGAGCACATATGTTGGAAATGCA

AAATCTACTCCGACGTTCTTTGGGACAAGAAGAAGTTACTCAGCTTGAAACCAATGCGGTTTTATTTGAAGATTTA

TTTGGCAGAGCACCTGTTGGTGATGAAGATAATTAA

4256.2

ATGAAAAAACAAGCCTATGTCATTATTGCTCTCACCTCCTTCCTATTTGTCTTTTTTTTCTCCCACAGCTTGCTGGA

AATACTTGATTTTGACTGGTCTATCTTTTTGCACGATGTCGAAAAAACAGAAAAATTTGTCTTTTTATTGTTGGTTT

TCAGCATGTCCATGACCTGTCTCTTAGCCCTGTTTTGGCGAGGGATCGAAGAGCTTTCTCTAAGAAAAATGCAGGC

TAATCTCAAGCGTTTATTAGCAGGGCAAGAAGTGGTTCAGGTTGCAGATCCAGATTTGGATGCCAGTTTCAAGTCC

TTATCAGGTAAACTTAACCTTTTGACAGAGGCTCTTCAAAAAGCTGAAAATCAGAGCCTTGCTCAGGAAGAGGAA

ATCATCGAGAAGGAACGGAAGCGAATTGCTCGGGATTTGCACGATACAGTCAGTCAGGAGTTGTTTGCGGCCCAC

ATGATTTTATCGGGTATCAGTCAGCAGGCTTTGAAATTGGATAGAGAAAAGATGCAGACCCAGTTGCAGAGTGTC

ACAGCTATTTTAGAAACAGCCCAGAAGGATTTGCGGGTTTTGCTCTTGCATTTGCGACCAGTTGAACTGGAGCAGA

AGAGCTTGATAGAAGGGATTCAAATTCTTTTAAAAGAGCTTGAGGACAAGAGTGATCTTAGGGTTAGTCTCAAGC

AGAATATGACGAAATTGCCTAAGAAAATCGAGGAGCATATCTTCCGTATCCTGCAAGAGTTGATTAGCAATACCC

TCCGCCATGCCCAGGCATCTTGCCTAGATGTCTACCTCTATCAGACAGATGTTGAATTGCAACTGAAGGTGGTGGA

CAATGGGATTGGTTTCCAGTTAGGGAGCTTAGACGACTTGAGTTATGGACTGCGAAATATCAAGGAGCGGGTTGA

AGATATGGCTGGAACAGTTCAACTCTTGACAGCTCCCAAGCAAGGGCTGGCGGTTGATATCCGTATTCCCCTGTTA

GATAAGGAATGA

4263.1

ATGATTGTTTCCATTATTTCTCAAGGATTTGTCTGGGCTATTCTAGGTCTGGGAATCTTTATGACATTTAGGATTTT

AAACTTTCCAGATATGACGACAGAAGGTTCCTTCCCTCTTGGGGGAGCTGTTGCTGTCACTTTGATAACCAAAGGC

GTGAACCCATTTTTAGCGACACTTGTTGCTGTAGGAGCAGGTTGTTTGGCTGGAATGGCAGCAGGCCTTCTTTATA

CAAAAGGGAAGATCCCAACCTTGCTCTCAGGGATTTTGGTGATGACTTCTTGTCACTCAATCATGCTCTTGATTAT

GGGACGTGCGAATTTAGGCCTGCTTGGAACCAAGCAAATTCAGGATGTTTTGCCTTTTGATTCGGATTTGAATCAA

CTCTTGACAGGTCTCATCTTTGTGAGTATTGTTATTGCTCTCATGCTCTTTTTCTTGGACACTAAACTCGGACAAGC

CTATATTGCTACAGGGGATAATCCTGATATGGCTAGAAGTTTCGGGATTCATACTGGACGCATGGAGCTCATGGGC

TTGGTCTTATCAAATGGTGTGATTGCCCTTGCAGGTGCCCTCATTGCTCAGCAAGAAGGTTATGCCGATGTGTCTC

GAGGGATCGGGGTTATCGTTGTGGGGCTTGCAAGTTTGATTATTGGAGAAGTTATTTTCAAGAGTTTGAGCTTGGC

AGAGCGTTTGGTTACTATCGTTGTAGGTTCTATCGCTTATCAATTTTTAGTGTGGGCAGTTATCGCACTTGGCTTTA

ATACAAGTTACCTTCGTTTATACAGTGCCTTGATTTTAGCAGTCTGCCTCATGATTCCAACATTTAAGCAAACAAT

CTTGAAAGGAGCCAAGTTAAGCAAATGA

4346.1

ATGAAAAAAATGAAAGTTTGGTCTACTGTACTTGCAACGGGAGTTGCTCTTACTACACTTGCTGCTTGCTCTGGAG

GTTCAAATTCTACGACTGCTTCTTCATCTGAAGAAAAAGCTGATAAAAGTCAAGAATTAGTTATCTATTCGAACTC

AGTCTCAAATGGTCGTGGTGATTGGTTAACTGCTAAAGCAAAAGAAGCTGGTTTTAATATAAAAATGGTTGATATC

GCTGGCGCTCAATTAGCAGACCGTGTTATTGCTGAGAAGAATAATGCAGTTGCAGATATGGTATTTGGAATTGGTG

CTGTTGATTCAAATAAAATTAGAGATCAAAAATTACTAGTACAGTACAAGCCTAAATGGTTAGATAAAATTGATC

AATCTTTATCAGATAAAGATAATTATTATAATCCTGTGATTGTTCAACCATTAGTTTTAATTGGGGCGCCTGATGTA

AAAGAAATGCCTAAAGATTGGACTGAATTAGGTAGTAAGTATAAAGGTAAATATTCAATTTCTGGTCTTCAAGGA

GGTACAGGACGGGCAATTCTAGCAAGTATCTTAGTTCGATACCTTGATGATAAAGGTGAATTAGGTGTTTCCGAAA

AAGGTTGGGAAGTAGCAAAAGAATATTTGAAAAATGCATACACTCTTCAAAAGGGAGAAAGTTCAATTGTTAAGA

TGTTAGACAAAGAAGATCCAATACAATATGGAATGATGTGGGGTTCTGGTGCATTAGTTGGACAAAAAGAACAAA

ATGTTGTTTTCAAAGTTATGACTCCTGAGATTGGTGTACCATTTGTAACTGAACAAACTATGGTTTTAAGCACTAG

TAAAAAACAAGCGTTAGCTAAAGAATTTATTGATTGGTTTGGTCAATCAGAAATTCAAGTAGAATATAGTAAGAA

CTTTGGATCTATTCCTGCAAATAAAGATGCCCTCAAAGATCTACCTGAAGATACGAAGAAATTTGTTGATCAAGTG

AAACCACAAAATATTGACTGGGAAGCTGTTGGAAAGCATTTGGATGAATGGGTAGAAAAAGCTGAATTAGAATAC

GTACAATAA

4346.2

ATGATTAAATTTGATAATATTCAAATTAAATATGGTGATTTTGTTGCAATTGATAATCTGAATTTAGATATACATG

AAGGGGAATTTTTTACATTTCTTGGGCCTTCAGGATGTGGTAAATCAACTACTTTGAGAGCATTGGTAGGTTTTCT

AGATCCATCATCAGGAAGTATTGAAGTTAATGGAACAGATGTCACTCATTTGGAACCTGAAAAGCGTGGAATTGG

TATTGTATTTCAATCTTATGCGCTATTTCCAACTATGACTGTTTTTGATAATATTGCATTTGGTTTAAAAGTTAAGA

AGGTAGCTCCAGATGTTATTAAAGCTAAAGTATCAGCAGTGGCAGCAAAAATTAAGATCTCTGATCAACAGTTAC

AGCGTAATGTATCAGAATTATCTGGGGGTCAACAACAAAGGGTAGCATTGGCTCGTGCTCTGGTTCTTGAACCTAA

AATTCTTTGTCTAGATGAACCATTGTCAAACCTTGACGCAAAATTACGTGTAGATTTGAGAAAAGAGTTGAAAAGA

CTTCAAAAAGAGTTAGGTATTACTACTTTATATGTTACTCATGATCAAGAGGAAGCCTTGACTTTATCTGATAGAA

TTGCAGTCTTTAACAATGGATACATCGAACAGGTCGGTACACCAGTAGAGATTTATCATAATTCTCAAACTGAATT

TGTATGTGATTTTATTGGAGATATTAATGTTTTGACCGATGAAACAGTCCACGAAGTATTATTGAAAAATACAAGC

GTTTTCTTAGAGGATAAAAAAGGATACATTCGATTAGAGAAAGTTCGATTCAATCGTGAAACTGAACAAGATTTTA

TTCTAAAAGGGACAATTATTGATGTTGAGTTTTCTGGAGTTACAATTCACTATACAATAAAAGTTTCTGAAAGTCA

GATTCTTAATGTAACAAGTATTGATAGTCAGGCTGCTATTAGATCTGTCGGAGAAAGTGTGGAATTATTTATCACA

CCATCAGACGTTCTGCAATTTTAA

4346.3

ATGCGTCATAAATTAAATTTAAAAGATTGGCTTATTCGTTTAGGGTTAATCTGGTTCTTAGTAACATTTATTATTTA

TCCAAACTTTGATCTAGTAGTGAATGTATTTGTAAAAGGAGGAGAATTTTCCCTTGATGCTGTACATCGTGTTCTA

AAATCTCAGAGGGCACTTCAGAGTATTATGAACAGTTTTAAGTTAGCATTTTCACTCATTATTACAGTTAATGTCG

TAGGTATTCTTTGTGTTCTATTTACAGAGTACTTTGATATTAAAGGTGCTAAAATTTTAAAATTAGGTTATATGACC

TCTTTAATTTATGGAGGAGTGGTTTTAGCGACTGGATATAAATTTGTCTATGGTCCTTATGGATTGATTACAAAATT

TTTACAAAATGTTATCCCTTCTTTAGACCCTAACTGGTTTATTGGGTATGGTGCAGTCTTATTCATTATGACATTTT

CAGGAACTGCTAATCATACATTGTTTTTAACAAATACAATTCGAAGCGTTGACTATCACACTATTGAGGCTGCTCG

AAATATGGGAGCAAAACCATTTACTGTTTTCCGAAAAGTAGTGTTACCAACCTTAATTCCAACTCTATTTGCACTT

ACTATTATGGTTTTTCTTAGTGGTTTATCTGCAGTAGCAGCACCCATGATTGTTGGTGGTAAAGAATTTCAAACTAT

AAATCCAATGATTATTACATTTGCAGGGATGGGGAATTCTCGTGATTTAGCTGCCCTACTTGCAATTATTTTAGGT

ATTGCAACTACAATTTTGCTTACTATCATGAATAAGATAGAAAAAGGTGGAAATTATATTTCTATCTCTAAGACTA

AAGCGCCTCTTAAAAAACAAAAAATTGCGTCTAAGCCTTGGAATATCATTGCTCACATTGTAGCATATGGATTGTT

CACAGTTTTCATGCTTCCACTAATTTTTATAGTATTATACTCATTTACAGATCCAGTTGCAATTCAAACAGGTAACT

TAACATTATCAAACTTTACTTTAGAAAATTATCGCTTATTCTTTAGTAATAGTGCGGCATTCTCTCCATTCTTGGTC

AGCTTTATTTATTCTATTATTGCTGCGACAACAGCAACAATTCTCGCAGTTGTATTTGCTCGTGTTGTCAGAAAACA

TAAATCTCGTTTTGATTTCTTATTTGAATATGGTGCTCTACTTCCTTGGTTACTACCAAGTACACTTTTAGCAGTAA

GTTTATTATTTACTTTTAATCAGCCACAATTTCTTGTCTTGAATCAGATTTTGGTAGGTAGTTTGGTAATTCTACTT

ATTGCATATATAGTTGTAAAAATCCCATTTTCTTATAGAATGGTACGTGCTATTTTATTTAGTGTTGATGATGAGAT

GGAAGATGCAGCAAGAAGTATGGGTGCTTCACCTTTTTATACTATGATGAAGGTTATCATTCCATTTATTTTACCG

GTTGTTCTCTCTGTTATTGCTTTAAACTTTAACTCTTTATTAACTGACTTCGACTTATCTGTATTCCTTTACCATCCC

CTAGCTCAACCATTAGGTATTACGATTCGATCTGCAGGTGATGAAACAGCAACATCTAATGCACAAGCTCTGGTAT

TTGTTTATACAATTGTTCTGATGATTATTTCTGGAACGGTATTATACTTCACACAAAGACCGGGGCGTAAAGTAAG

GAAATAA

Table 2

MEELVTLDCLFIDRTKIEANANKYSFVWKKTTEKFSAKLQEQIQVYFQEETTPLLIKYAMFDKKQKRGYKESAKNLANW

HYNDKEDSYTHPDGWYYRFHHTKYQKTQTDFQQEIKVYYADEPESAPQKGLYMNERYQNLKAKECQALLSPQGRQIF

AQRKIDVEPVFGQIKASLGYKRCNLRGKRQVRIDMGLVLMANNLLKYSKMKZ

MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVYADETLITHTAEKPKEEKMIVEEKADKALETKNIV

ERTEQSEPSSTEAIASEKKEDEAVTPKEEKVSAKPEEKAPRIESQASNQEKPLKEDAKAVTNEEVNQMIEDRKVDFNQN

WYFKLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTFKLDEKDLKKNVRLTF

DGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLQKDGRENVIAVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHV

EKNGTTILTPKLEEQQHGKVETHVTSKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVER

PKLWTVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLHHDHGALGAEENYKAE

YRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFDTWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFD

LRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDA

VGFNYSEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDRVGWGKTATASWTFD

RDNAGYAGQFIWTGTDYIGERTPWHNQNQTPVKSSYFGIVDTAGIPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENK

ELASKVADSEGKIPVRAYSNASSVELFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEALARDES

GKELARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHGQGQLVGVDNGEQASRER

YKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLKSNQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPT

TVPFVYSDGSRAERPVTWSSVDVSKPGIVTVKGMADGREVEARVEVLALKSELPVVKRIAPNTDLNSVDKSVSYVLIDGS

VEEYEVDKWEIAEEDKAKLAIPGSRIQATGYLEGQPIHATLVVEEGNPAAPAVPTVTVGGEAVTGLTSQKPMQYRTLA

YGAKLPEVTASAKNAAVTVLQASAANGMRASIFIQPKDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSV

RAHYQDGTQAVLPADKVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKDQVELTIQANTEKKIAQSIRPVNVVT

DLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQTFEVLGKVEGIDLEARAKVSVEGIVSVEEVSVTTPIAEAP

QLPESVRTYDSNGHVSSAKVAWDAIRPEQYAKEGVFTVNGRLEGTQLTKLHVRVSAQTEQGANISDQWTGSELPLAF

ASDSNPSDPVSNVNDKLISYNNQPANRWTNWNRTNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVGVPKSYVIEY

YVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHFSFDKVETYAVRIRMVKADNKRGTSITEV

QIFAKQVAAAKQGQTRIQVDGKDLANFNPDLTDYYLESVDGKVPAVTASVSNNGLATVVPSVREGEPVRVIAKAENGD

ILGEYRLHFTKDKSLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLTVEWEEVPAENLTKAGQFTVR

GRVLGSNLVAEITVRVTDKLGETLSDNPNYDENSNQAFASATNDIDKNSHDRVDYLNDGDHSENRRWTNWSPTPSSNP

EVSAGVIFRENGKIVERTVTQGKVQFFADSGTDAPSKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYR

ADKDIAAGDEINVTFKAIKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELADFAENRQDYQIT

YKGQRPKVSVEENNQVASTVVDSGEDSFPVLVRLVSESGKQVKEYRIHLTKEKPVSEKTVAAVQEDLPKIEFVEKDLAY

KTVEKKDSTLYLGETRVEQEGKVGKERIFTAINPDGSKEEKLREVVEVPTDRIVLVGTKPVAQEAKKPQVSEKADTKPID

SSEASQTNKAQLPSTGSAASQAAVAAGLTLLGLSAGLVVTKGKKEDZ

MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESFSESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVT

TDKHLEKNCCKLELEPQINNDIVNSESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGG

GESYKLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQDRLGHGTAVVAQIVGDDN

INGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIINLSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGV

IIVAALGNDSLNVSNQSDLLKLISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLSEL

GLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNYMFVKKFWKKHYQZ

MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFILDWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLP

PEESSSDLVINGKAPFAVYFQDYMAKKLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAML

KTLVESQGGDFEKVEKVPNNDSNSITPIANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYVKEFDYYSPVIIANND

YLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKEKRDFVIESQKYLSKEYASDKEKWGQFDAARWNAFY

KWDKENGILKEDLTDKGFTNEFVKZ

MKRTWRNSFVTNLNTPFMIGNIEIPNRTVLAPMAGVTNSAFRTIAKELGAGLVVMEMVSDKGIQYNNEKTLHMLHIDE

GENPVSIQLFGSDEDSLARAAEFIQENTKTDIVDINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMR

TGWADPSLAVENALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAKQRIEEVGA

DAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLINLKGENVAVREFRGLAPHYLRGTSGAAKL

RGAISQASTLAEIETLLQLEKAZ

MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGEKFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLK

RDIVDKRLPLVHDLDIKDGKLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFSYF

YTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIYELESRNEQIVKLQNQKVSFVRGAS

HELKTPLASLRIILENMQHNIGDYKDHPKYIAKSINKIDQMSHLLEEVLESSKFQEWTECRETTVTVKPVLVDILSRYQELAH

SIGVTIENQLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEHLFDIFYHSQIVTD

KDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISLZ

MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLTKYVTLLNDKALDSGLELAIHSEDENLRLSIGAATK

GRDIRSLFLESAVKYQILVYLLYHQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIHYFYFCL

FRKVWSSQEWEGHMQKPERKQEIANLEEICGASLSAGQKLDLVLWAHISQQRLRVNACQFQVTEEKMRGYFDNIFYLR

LLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLHTMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYEL

SQLCAQVYLYKGYILQDRYKYQLENRHPYLLMEHDFKETAEEIFHALPAFQQGTDLDKKILWEWLQLIEYMAENGGQ

HMRIGLDLTSGFLVFSRMAAILKRYLEYNRFTTIEAYDPSRHYDLLVTNNPIHKKEQTPVYYLKNDLDMEDLVAIRQLLF

TZ

MEFSKKTRELSIKKMQERTLDLLIIGGGITGAGVALQAAASGLETGLIEMQDFAEGTSSRSTKLVHGGLRYLKQFDVEV

VSDTVSERAVVQQIAPHIPKSDPMLLPVYDEDGATFSLFRLKVAMDLYDLLAGVSNTPAANKVLSKDQVLERQPNLKK

EGLVGGGVYLDFRNNDARLVIENIKRANQDGALIANHVKAEGFLFDESGKTTGWARDLLTDQVFEIKARLVINTTGPW

SDKVRNLSNKGTQFSQMRPTKGVHLVVDSSKIKVSQPVYFDTGLGDGRMVFVLPRENKTYFGTTDTDYTGDLEHPKVT

QEDVDYLLGIVNNRFPESNITIDDIESSWAGLRPLIAGNSASDYNGGNNGTISDESFDNLLATVESYLSKEKTREDVESAV

SKLESSTSEKHLDPSAVSRGSSLDRDDNGLLTLAGGKTTDYRKMAEGAMERVVDILKAEFDRSFKLINSKTYPVSGGELN

PANVDSEIEAFAQLGVSRGLDSKEAHYLANLYGSNAPKVFALAHSLEQAPGLSLADTLSLHYAMRNELTLSPVDFLLRR

TNHMLFMRDSLDSIVEPILDEMGRFYDWTEEEKATYRADVEAALANNDLAELKNZ

MMNELFGEFLGTLILILLGNGVVAGVVLPKTKSNSSGWIVITMGWGLAVAVAVFVSGKLSPAYLNPAVTIGVALKGGLP

WASVLPYILAQFAGAMLGQILVWLQFKPHYEAEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQA

GIGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPIPNKGDGDWSYAWIPVVGPVIGAALAVLVFSLFZ

MTKKKIERISVIHREKILWLKWYFMRDKEQPKYSVLERKMFDAAKNQDMLAYQKYATIKQITDIRVQTSEADILEAVKE

VYVYNHMNVIGACQRILFISQSPAYDKLNKWFNIYSDLYFSVVPLPKMGVYHEMVGIZ

MKNSNEAEMKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLEYLSQQASFSITVTRFAQMARYLVL

NDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIF

EKVTAYLNQGQLAQESQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFS

EGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELEL

VARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINL

LRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAEKLLQKWSV

FLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVL

VQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLF

LSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVI

GKKLDQQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLHPDARSHGNFL

HRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQ

AFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMA

EPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRF

AINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNRZ

MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSAQNILVSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVK

AATELKERLEKKISKKIQETDDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLILENE

VFHEVFEAHYQGKQKETFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEKADFTSEKEKLTE

QIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQESDSQAYQAVLARVVAISKEKNGRALTNASRKA

DLKPLADAYNEERKTQFAKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADISHYTIE

ILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQIFNEKFQRYAQNPQEG

RLIILKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQLVFANTKLTPNPDNKAAFLLYDKDDTGEEEESQTETKL

TGEMRLVIKEILKLHQEKGVAFKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQD

YALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMASSQKGLIHTALAEKLKQFMDILASWRLYAKT

HSLYDLIWKIYNDRFYYDYVGALPNGPARQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKD

AVELMTIHKSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIKLSIPSLTYRQNEEE

LQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLESKEYPAAKNGKLNSNTRLQARNFQDWLWAISKVFTKDKLNF

SYRFIGEDQLTREAIGELETKSPLQDSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDM

EGVEIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLKQVQTSQAVRDKINLDKILAF

FDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVRGILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALY

EEALSRAYSIENIEKYLILLGKDEVQVVKVZ

MELARHAESLGVDAIATIPPIYFRLPEYSVAKYWNDISSAAPNTDYVIYNIPQLAGVALTPSLYTEMLKNPRVIGVKNSS

MPVQDIQTFVSLGGEDHIVFNGPDEQFLGGRLMGARAGIGGTYGAMPELFLKLNQLIADKDLETARELQYAINAIIGKL

TSAHGNMYGVIKEVLKINEGLNIGSVRSPLTPVTEEDRPVVEAAAALIRETKERFLZ

MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNTMDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLG

RGKKEEVASDFYQFIYLALGLSVVLLGMVLFLAPIILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLTKL

SMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQEKLKALHLEKRIPLNMDKIKEGV

RLGLPIGGTVFAEVAIFSVVGLIMAKFSPLIIASHQSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRW

TALIFAAFTLTFLYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYLGLLGYWGVAIP

VYAIZ

MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKA

PINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEEL

PVIDELEIQAQESQLFGERIEEDENQZ

MDTMISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVIFNTAKLATDIENNVRVVVYIRKDVEDNSQTIE

KEGQTVTNNDYHKVYDSLKNMSTVKSVTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANTPNDVKTIAEDA

KKIEGVSEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMRLVGAKNSYIRGPFLLEGAFIG

LLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPDLFSPLMIALLFVIGVFIGSLGSGISMRRFLKIZ

MKKVRFIFLALLFFLASPEGAMASDGTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYF

YLKSGGYMAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKADGQHAEKEW

LQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFYIKENGNYADKEWIFENGHYYYLKSGGY

MAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYD

SHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSDGK

WLGGKTTNENAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLATTISGLSGYMKTEDLQALDASKD

FIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLENPFLFKDLTEATNYSAEELDKVFSLLNI

NNSLLENKGATFKEAEEHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILGATKWI

KENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKDZ

MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLTYNYKFVGLNNFKLLFMDPKFMNAIGFTAIIAIAM

VVGEIALGIFLARVLNSKIKGQTFFRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFFQTSLLGTKWGAIFAAVF

VLLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSMVFILALKGGLTAFDQVFAMTGGGPNN

ATTSLGLLVYNYAFKNNQFGYANAIAVILFFLIVVISIIQLRVSKKFEIZ

MMKQDERKALIGKYILLILGSVLILVPLLATLFSSFKPTKDIVDNFFGFPTNFTWDNFSRLLADGIGGYYWNSVVTTVLSL

LAVMIFIPMAAYSIARNMSKRKAFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGYIKI

SIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVLNRDSKMWTLPLFQYNYAGQYFND

YGPSFASYVVGIISITIVYLFFQRHIISGMSNGAVKZ

MKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQSILSHKFFRLILQFVLFGSVLSAAFASLEH

FQIVKKFNYAFLSPNMQVWHQNRAEVTFFNPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRT

AFPAIIAGAIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMALFKQNPFWGEGPLTYM

NSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRLMMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQS

GFIFLLVMCSIPLEHRMLVSDMTDZ

MSKMDVQKIIAPMMKFVNMRGILALKDGMLAILPLTVVGSLFLIMGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAI

MGLISCFSIAYSYAKNSGVEALPAGVLSVSAFFILLRSSYIPKQGEAIGDALSKVWFGGQGIIGAIIIGLVVGSIYTFFIKRKIV

IKMPEQVPQAIAKQFEAMIPAFVIFLSSMIVYILAKSLTNGGTFIEMIYSAIQVPLQGLTGSLYGAIGLAFFLSFLWWFGVH

GQSVVNGVVTALLLSNLDANKAMLASANLSLENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVA

AFPAIFNVNEPVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFLVGGWQGVITQLVI

LAMSTLVYFPFFKVQDRLAYQNEIKQSZ

MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALDSTTVNLLETDPYITSGRHLVVPKDAPNQKVTASLP

VAHELESLQRDILACRRVWMSZ

MKKRYLVLTALLALSLAACSQEKTKNEDGETKTEQTAKADGTVGSKSQGAAQKKAEVVNKGDYYSIQGKYDEIIVAN

KHYPLSKDYNPGENPTAKAELVKLIKAMQEAGFPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYSEHQT

GLAFDVIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEIAASGLSLEEYYGF

EGGDYVDZ

MREPDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQKELEIELILAHVNHKQRIESDWEEKELRKLAAEAE

LPIYISNFSGEFSEARARNFRYDFFQEVMKKTGATALVTAHHADDQVETIFMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL

HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPELEKENPRFRDAILGIGNEILDYDLAIAELSNNINVEDLQQLFSYSES

TQRVLLQTYLNRFPDLNLTKAQFAEVQQILKSKSQYRHPIKNGYELIKEYQQFQICKISPQADEKEDELVLHYQNQVAY

QGYLFSFGLPLEGELIQQIPVSRETSIHIRHRKTGDVLIKNGHRKKLRRLFIDLKIPMEKRNSALIIEQFGEIVSILGIATNNL

SKKTKNDIMNTVLYIEKIDRZ

MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIYFREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQIT

EWRLNKQGIPVFKLSNHQFIAADKRFLYDQSEVTPTIKKVWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEGRE

FLHIDQAGWVAKESTSEEDNRMSKVQEMLSEKYQKDSFSIYVKQLTTGKEAGINQDEKMYAASVLKLSYLYYTQEKIN

EGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKEDNKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSA

IMGDDWDPKEKLISSKMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYADSPFIL

SIFTKNSDYDTISKIAKDVYEVLKZ

MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYTELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSK

EETGIQFFTPSVTKVEKFTSTILPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGGG

NGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGARIPAGVLLEGPPGTGKTLLAKA

VAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAKKAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDG

FEGNEGIIVIAATNRSDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFVGADLEN

VLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHEAGHTIVGLVLSNARVVHKVTIVPRGRA

GGYMIALPKEDQMLLSKEDMKEQLAGLMGGRVAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEG

NHAMLGAQSPQKSISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYETGKMPEAVE

EESHALSYDEVKSKMNDEKZ

MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGNSQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENP

SQDKVEGIRDLFLTILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW

VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTVYSSSSKMEAMKPYIDTGQG

YTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQLLWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLELAS

GAQNLRAKEVGAYELREVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQR

VVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINENVAFDNLVLPKLVLQPLVENALYHGI

KEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQDAGDSSQSQLKRGGVGLQNVDQRLKLHFGANYHMKIDSRPQKGTKV

EIYINRIETSZ

MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGNSQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENP

SQDKVEGIRDLFLTILKSDKDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW

VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQHTVYSSSSKMEAMKPYIDTGQG

YTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQLLWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIAS

GAQNLRAKEVGAYELREVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFHDSQR

VVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINENVAFDNLVLPKLVLQPLVENALYHGI

KEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQDAGDSSQSQLKRGGVGLQNVDQRLKLHFGANYHMKIDSRPQKGTKV

EIYINRIETSZ

MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANSLNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASI

VVQLLQMDILPKFVEWGKQGEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTAGSMI

VTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSIIFVIILIITVLLIIYFTTYVQQAEYKIPIQYTK

VAQGAPSSSYLPLKVNPAGVIPVIFASSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTF

VQINPEKAAETYKRVVPISMEFVLVKVQKNICLNFFVVLQLLVPSSLVZ

MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPDINRAAEKIYQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIG

AATDATDYVVLAKALDKAAKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTAVAD

MGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGVVKRALEKVRGQSFDVVAETVKK

TAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPAVGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMAC

NQVGGLSGAFIPVSEDEGMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKTTAVRII

PKGKEGDMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKNZ

MTQIIDGKALAAKLQGQLAEKTAKLKEETGLVPGLVVILVGDNPASQVYVRNKERSALAAGFRSEVVRVPETITQEELL

DLIAKYNQDPAWHGILVQLPLPKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEG

KNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLSKVAAKADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDEN

GKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQAALRTLDRKZ

MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISKTVGLNVPNMAKIGLGNIPRETPLKTVAAESNPTGY

ATKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIYDFGPRQMETGELII

YTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRTANRRDLAVSPFFPTVLDKLNEAGI

DTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTLLKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDE

RLPEIIAAMRENDLLLITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETAMIGESFL

DKLVZ

MFISISAGIVTFLLTLVEIPAFIQFYRKAQITGQQMHEDVKQHQAKAGTPTMGGLVFLITSVLVAFFFALFSSQFSNNVGM

ILFILVLYGLVGFLDDFLKVFRKINEGLNPKQKLALQLLGGVIFYLFYERGGDILSVFGYPVHLGFFYIFFALFWLVGFSN

AVNLTDGVDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLGFFIFNHKPAKVFMGDVGSLALGGMLAAISMA

LHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKRIFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLT

LAILYLMZ

LFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLA

YHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFL

SNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVVIIA

LVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVP

LTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVLGWGLPGIW

AGSLLDNGFRWLFLRYRYQRYMSLKGZ

MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLTYLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVA

FQSVAPLIMIGQSHGSGAMFGALIASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLLLA

AITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTPLYFGMPTFEISSIVMMCIIATVSMVEST

GVYLALSDTTKDPIDSTRLRNGYRAEGLAVLLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGA

LAQIIPSSVLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTAFQMFFSNGIVVASL

LAIVLNAVLNHKKKZ

MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEIKKKHETTLKGIFHAHKNGFG

FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKN

QKISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVP

DAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLEFGVHIADVSYYVTEGSALDKEALNRATSVYVTD

RVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIE

LMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHE

EPKAEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYT

HFTSPIRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIV

KFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQS

SRSGRGRDSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTKZ

MGTTGFTIIDLIILIVYLLAVLVAGIYFSKKEMKGKEFFKGDGSVPWYVTSVSIFATMLSPISFLGLAGSSYAGSWILWFA

QLGMVVAIPLTIRFILPIFARIDIDTAYDYLDKRFNSKALRIISALLFIIYQLGRMSIIMYLPSAGLSVLTGIDINILIILMGVV

AIVYSYTGGLKSVLWTDFIQGVILISGVVLALFVLIANIKGGFGAVAETLANGKFLAANEKLFDPNLLSNSIFLIVMGSGF

TILSSYASSQDLVQRFTTTQNIKKLNKMLFTNGVLSLATATVFYLIGTGLYVFYQVQNADSAASNIPQDQIFMYFIAYQL

PVGITGLILAAIYAASQSTISTGLNSVATSWTLDIQDVISKNMSDNRTKIAQFVSLAVGLFSIGVSIVMAHSDIKSAYEWF

NSFMGLVLGLLGGVFILGFVSKKANKQGAYAALIVSTIVMVFIKYFLPPTAVSYWAYSLISISVSVVSGYIVSVLTGNKVS

APKYTTIHDITEIKADSSWEVRHZ

MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDGSQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYV

TSHGDHYHYYNGKVPYDALFSEELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQK

QEHVKDNEKVNSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLSASELAAAKAHLAGKNM

QPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELYDSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHF

IPYSKLSALEEKIARMVPISGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAYIVRHGD

HFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRIIAEDESGFVMSHGDHNHYFFKKDLTEEQIK

VRKNIZ

MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHK

HMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGNZ

MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDTVKGFAYTDMKQKLRLTTLEVTATQDQFGWGRVT

EVRKDLGVFVDTGLPDKEIVVSLDILPELKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQN

WPAIVYRLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSFEMLENDAQMILTYLE

SNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQDQFGTELIZ

MKDVSLFLLKKVFKSRLNWIVLALFVSVLGVTFYLNSQTANSHSLESRLESRIAANERAINENEEKLSQMSDTSSEEYQF

AKNNLDVQKNLLIRKTEILTLLKEGRWKEAYYLQWQDEEKNYEFVSNDPTASPGLKMGVDRERKIYQALYPLNIKAH

TLEFPTHGIDQIVWILEVIIPSLFVVAIIFMLTQLFAERYQNHLDTAHLYPVSKVTFAISSLGVGVGYVTVLFIGICGFSFLV

GSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFPGLLLAFLAFIVIVEVVYLIAYFFKQKMPVLFLSLIGIVGLLFGIQTIQP

LQRLAHLIPFTYLRSVEILSGRLPKQIDNVDLNWSMGMVLLPCLIIFLLLGILFIERWGSSQKKEFFNRFZ

MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVGFLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAI

VAVALTTYGSATAMIMFAGMVFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSISPAF

VQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRDSTVSITLSMAVIYIIVAIFAGSEYIEK

EISSGTSGLVYALQLAGQFAAGVFVILAGVRLILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFVGGLVS

MVIMIASGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGLGFQGSTFSDADFGLSGII

LGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSATEEZ

MIKTFLSALSVILFSIPIITYSFFPSSNLNIWLSTQPILAQIYAFPLATATMAAILSFLFFFLSFYKKNKQIRFYSGILLLLSLIL

LLFGTDKTLSSASNKTKTLKLVTWNVANQIEAQHIERIFSHFDADMAIFPELATNIRGEQENQRIKLLFHQVGLSMANYD

IFTSPPTNSGLAPVTVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQ?NIPDIIALHTAPPLPGLMEIWKQDLNIIHNQLASKYP

KAIIAGDFNATMRHGALAKISSHRDALNALPPFERGTWNSQSPKLFNATIDHILLPKNHYYVKDLDIVSFQNSDHRCIFT

EITFZ

MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKTVESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGL

ENVSPELETVAKLKDKEAVTGEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEEL

AKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFTDYESSQTLLGNSEAQVSAARFYVE

NPKEMDGLMKQVENLALENQGYQVEKENKAFEQIKDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGIL

LALGKGKSSIFLQFCLEVVLVSLGALLPAFVAGNAITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAESYVFLVLLS

CLSVALCFLFLFRKSPKEILSSISZ

MLHNAFAYVVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKASQETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKKI

TENKAIESYVKRINAIGDLTGYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDKDK

ILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTYSQELYENTAITDIHTAAKLYGY

TEDTAIYGDATFFVTADKNLDDVMKELNGISGINWKSYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALL

LSLWINARRKEVGILLSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASKAAQASNLGG

GAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQPKELLLDGEZ

MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQSKETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSV

AGVFIYGHIIGTIYNYIGIVIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIDWLDKGNRFDRFFIFMMIWPISPADFLCMLA

ALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQMLZ

MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGSSMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDE

ASAKEAIKEEKLKGYLTIDQEDSVLKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDE

AKENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRSASHYFYARMMALFLVILTHIGIYVVGGL

AAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISLFMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAA

GDNLLLKIGSYIPFISTFFMPFRTINDYAGGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTFKRALSYKZ

MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQSYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFV

GDLNRAEKGARLHTDTFQPQGVEGLLISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFG

MALGVPNQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQFGQAEPSSTRKNLEQK

KLLZMLKLIAIVGTNSKRSTNRQLLQYMQKHFTDKAEIELVEIKAIPVFNKPADKQVPAEILEIAAKIEEADGVIIGTPEYD

HSIPAVLMSALAWLSYGIYPLLNKPIMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDL

DVIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENLZ

MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNS

QQTYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDAL

LETATIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLP

LPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVDDVDFZ

MRCKMLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPDDILDFILVAFPLAILGARLYYVIFRFDYYSQNLG

EIFAIWNGGLAIYGGLITGALVLYIFADRKLINTWDFLDLAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQ

MYIEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHTTAFYLIWYGFGRMVIEGMRTDSLMFFGFRVSQWLSVVLI

GLGIMIVIYQNRKKAPYYITEEENZ

MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDPEYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEIT

VDSILAQTKSYAFQATEASKNQLNNLKEQWQEKAEALDDSEEIVIDTTEEZ

MKTKLIFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVYLKPETIQYNFHILMNYLTNPFSQVLQMPDFRSSAAG

LHHFAVVKNLFHLVQLVALVTLPSFYVFVNRIVKKDFLSLYRKSLLALVVLPVMIGLGGVLIGFDQFFTLFHQILFVGD

DTWLFDPAKDPVIMILPETFFLHAFLLFFALYENFFGYLYLKSRRKZ

MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKT

YIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVT

TGTALRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTEIQPGDEVPNHFSYTSRDEDY

VKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLST

SLPEDVQRDLVHSIKGLENAEMMRTGYAIEYDMVLPHQLRATLETKISGLFTAGQTNGTSGYEEAAGQGIIAGINAAL

KIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMRITEMGREIGLVDDERWARFEIKKNQF

DNEMKRLDSIKLKPVKETNAKVEEMGFKPLTDAVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISK

AMDQVAKMKRMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEGKNRSISKTLQKSKZ

MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIM

MVSAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKA

NKLLSLTPKEFESDKNPFFEVFKVSKVTAQZ

MTTFKDGFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVAREITLGVLEGKYYPNHEAIDFYHRYKEDIALF

AEMGFKCFRTSIAWTRIFPKGDELEPNEEGLQFYDNLFDECLKNGIEPVITLSHFEMPYHLVTEYGGWKNRKLIDFFARF

AEVVFKRYKDKVKYWMTFNEINNQANYQEDFAPFTNSGIVYEEGDNREAIMYQAAHYELVASARAVKIGHEINPDFQI

GCMIAMCPIYPVTCNPKDILMAMKAMQKRYYFADVHVLGKYPEHIFKYWERKGISVDFTAQDKEDLLGGTVDYIGFS

YYMSFAIDSHRENNPYFDYLETEDLVKNNYVKASEWEWQIDPEGLRYALNWFTDHYHLPLFIVENGFGAIDQVAADG

MVHDDYRIEYLGAHIREMKKAVVEDGVDLMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDNGKGSYNRSPKKSFG

WYKEVISSNGESVEZ

MDQQNGLFGFLENHVMGPMGKLAQFKVVRAITAAGMAAVPFTIVGSMFLVFSILPQAFSFWPIVADIFSASFDKFTSLY

MVANYATMGSLSLYFVLSLAYELTKIYAEEEELNMNPLNGALLALMAFVMTVPQIIFDGGMMKTVTSLKEGAVLADG

WAMGNVVARFGTTGIFTAIIMAIVTVLTYRMCVKHNWVIKMPEAVPEGVSRGFTALVPGFVVAFVVIFINGLLVAMGT

DIFKVLAIPFGFVSNLTNSWIGLMIIYLLTQLLWIVGIHGANIVFAFVSPIALANMAENAAGGHFAVAGEFSNMFVIAGGS

GATLGLCLYIAFASKSEQLKAIGRASVVPALFNINEPLIFGLPIIYNPALAIPFILAPMVTATIYYVANSLNFIKPIIAQVPWP

TPVGIGAFLGTADLRAVLVALVCAFAAFLVYLPFIRVYDQKLVKEEQGIZ

MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVGGYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTALLEQ

MPVGVMKLNLSSGEVEWFNPYAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR

EQAITDELVTSRPVIGIVSVDNYDDLEDETSESDISQINSFVANFISEFSEKHMMFSRRVSMDRFYLFTDYTVLEGLMNDK

FSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIGKVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRT

RTRTRAMMTAISDKIRSVDQVFVVGHKNLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFIEKEGVTK

LLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQTIVIDHHRRDQDFPDNAVITYIESGASSASELVTELIQFQNS

KKNRLSRMQASVLMAGMMLDTKNFTSRVTSRTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGRKLGSDVLI

AEAKDMKCYDTVVISKAADAMLAMSGIEASFVLAKNTQGFISISARSRSKLNVQRIMEELGGGGHFNLAAAQIKDVTLS

EAGEKLTEIVLNEMKEKEKEEZ

MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVALLQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFF

RAKDLARLGLSYLVIVGSNILGSILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKENL

GFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAFCLLALVVIMSRTLGISVZ

MKEKNMWKELLNRAGWVILVFLLAVLLYQVPLVVTSILTLKEVALLQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFF

RAKDLARLGLSYLVIVGSNILGSILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKENL

GFVVGTTVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAFCLLALVVIMSRTLGISVZ

MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGLGQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHF

LPFYGRAHIAYIPDGRVAGLSKLARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPGT

ATLTTVARGLFETDKDLRDQAYRLMGLZMKDLFLKRKQAFRKECLGYLRYVLNDHFVLFLLVLLGFLAYQYSQLLQH

FPENHWPILLFVGITSVLLLLWGGTATYMEAPDKLFLLVGEEEIKLHLKRQTGISLVFWLFVQTLFLLLFAPLFLAMGY

GLPVFLLYVLLLGVGKYFHFCQKASKFFTETGLDWDYVISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKAV

QKVPGKIWQNLYLRSYLRNGDLFALSLRLLLLSLLAQVFIEQAWIATAVVVLFNYLLLFQLLALYHAFDYQYLTQLFPL

DKGQKEKGLQEVVRGLTSFVLLVELVVGLTTFQEKLALLALLGAGLVLLVLYLPYQVKRQMQDZ

MRKSIVLAADNAYLIPLETTIKSVLYHNRDVDFYILNSDIAPEWFKLLGRKMEVVNSTIRSVHIDKELFESYKTGPHINYA

SYFRFFATEVVESDRVLYLDSDIIVTGELATLFEIDLKGYSIGAVDDVYAYEGRKSGFNTGMLLMDVAKWKEHSIVNSL

LELAAEQNQVVHLGDQSILNIYFEDNWLALDKTYNYMVGIDIYHLAQECERLDDNPPTTVHYASHDKPWNTYSISRLRE

LWWVYRDLDWSEIAFQRSDLNYFERSNQSKKQVMLVTWSADIKHLEYLVQRLPDWHFHLAAPCDCSEELTSLSQYTN

VTVYQNVLHSRIDWLLDDSIVYLDINTGGEVFNVVTRAQESGKKIFAFDITRKSMDDGLYDGIFSVERPDDLVDRMKNI

EIEZ

MTKIYSSLAVKKGLFTSFLLFIYVLGSRIILPFVDLNTKDFLGGSTAYLAFSAALTGGNLRSLSIFSVGLSPWMSAMILWQ

MFSFSKRLGLTSTSIEIQDRRKMYLTLLIAVIQSLAVSLRLPVQSSYSAILVVLMNTILLIAGTFFLVWLSDLNASMGIGGSI

VILISSMVLNIPQDVLETFQTVHIPTGIIVLLALLTLVFSYLLALMYRARYLVPVNKIGLHNRFKRYSYLEIMLNPAGGMP

YMYVMSFLSVPAYLFILLGFIFPNHSGLAALSKEFMVGKPLWVYVYISVLFLFSIIFAFVTMNGEEIADRMKKSGEYIYGI

YPGADTSRFINRLVLRFSVIGGLFNVIMAGGPMLFVLFDEKLLRLAMIPGLFMMFGGMIFTIRDEVKALRLNETYRPLIZ

MSSLSDQELVAKTVEFRQRLSEGESLDDILVEAFAVVREADKRILGMFPYDVQVMGAIVMHYGNVAEMNTGEGKTLT

ATMPVYLNAFSGEGVMVVTPNEYLSKRDAEEMGQVYRFLGLTIGVPFTEDPKKEMKAEEKKLIYASDIIYTTNSNLGFD

YLNDNLASNEEGKFLRPFNYVIIDEIDDILLDSAQTPLIIAGSPRVQSNYYAIIDTLVTTLVEGEDYIFKEEKEEVWLTTKG

AKSAENFLGIDNLYKEEHASFARHLVYAIRAHKLFTKDKDYIIRGNEMVLVDKGTGRLMEMTKLQGGLHQAIEAKEHV

KLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRIPTNRPRQRIDYPDNLYTTLPEKVYASLEYIKQ

YHAKGNPLLVFVGSVEMSQLYSSLLFREGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRGTDIKLGKGVAEL

GGLIVIGTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDMTQPEVLKGRKYRKL

VEKAQHASDSAGRSARRQTLEYAESMNIQRDIVYKERNRLIDGSRDLEDVVVDIIERYTEEVAADHYASRELLFHFIVTN

ISFHVKEVPDYIDVTDKTAVRSFMKQVIDKELSEKKELLNQHDLYEQFLRLSLLKAIDDNWVEQVDYLQQLSMAIGGQS

ASQKN?PIVEYYQEAYAGFEAMKEQIHADMVRNLLMGLVEVTPKGEIVVTHFPZ

MIGTFAAALVAVLANFIVPIEITPNSANTEIAPPDGIGQVLSNLLLKLVDNPVNALLTANYIRILSWAVIFGIAMREASKNS

QELLKTIADVTSKIVEWIINLAPFGILGLVFKTISDKGVGSLANYGILLVLLVTTMLFVAPVVNPLIAFFFMRRNPYPLVW

NCLRVSGVTAFFTRSSATNIPVNMKLCHDLGLNPDTYSVSIPLGSTINMAGVAITINLLLAAVNTLGIPVDFATAFVLSV

VAAISSCDASGLAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIGVIQDSCETALNSSTDVLFTAVAEYAATRKKZ

MSISQRTTKLILATCIACLLAYFLNLSSAVSAGILALLSLSDTRRSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLY

LAFYVPLAYKMGWEIGITPSTVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLKDI

LQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMRQRQSRILRNMAQQINTCHLAAS

ESLILAQLFSKUIAGQLSQTNPASDLLDEIERYLEVFRNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYRQZ

MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQEATNLRGQAEREADLLVNEAKRESKSLKKEALLEAK

EEARKYREEVDAEFKSERQELKQIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE

LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRIAGEYVAESTNSTVHLPDDTMKG

RIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFDPIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEA

AAYEIGAPNLHPDLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAIDHEVEGSHVE

IGMELARKYKEPPVVVNTIASHHGDVEAESVLAVIVAAADALSAARPGARSESLESYIKRLHDLEEIANGFEGVQTSFAL

QAGREIRIMVNPGKIKDDKVTILAHKVRKKIENNLDYPGNIKVTVIRELRAVDYAKZ

MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSEKSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKR

RKEEEEKKIKEQIAKEKEDGEKIZ

MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQLYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKI

AIMDGDQFGSDFVKLNPNSKIPALLDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLG

GGFGHFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYLAGNDYTIADIAIWSWYGQLVQGNLYQGSAKFLDASS

YQNLVKWAEKIANRPAVKRGLEVTYTEIKZ

LASLITSIIMFYVGFDVLRDTIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSNALKAAAKDNLSDAVTSL

GTAIAILASSFNYPIVDKLVAIITTFFILKTAYDIFIESSFSLSDGFDDRLLEDYQKAIMEIPKISKVKSQRGRTYGSNIYLDIT

LEMNPDLSVFESHEIADQVESMLEERFGVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQ

DGEQMDKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETKKEZ

MTIKLVATDMDGTFLDGNGRFDMDRLKSLLVSYKEKGIYFAVASGRGFLSLEKLFAGVRDDIIFLAENGSLVEYQGQDL

YEATMSRDFYLATFEKLKTSPYVDINKLLLTGKKGSYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEE

TLEDGEAWVNENVPGVKAMTTGFESIDIVLDYVDKGVAIVELVKKLGTTMDQVMAFGDNLNDLHMMQVVGHPVAPE

NARPEILELAKTVIGHHKERSVIAYMEGLZ

MADIKLIALDLDGTLLTTDKRLTDRTKETLQAARDRGIKVVLTTGRPLKAMDFFLHELGTDGQEDEYTITFNGGLVQK

NTGEILDKTVFSYDDVARLYEETEKLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFA

QEPLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGIDQSQVMACGDEANDLSMI?EWAGLGVAM

QNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKENZ

MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQLDYRFDQARQASQLDQKDLEVVVSDRLQEVRIELH

QGLTQVRQEMTDNLLQTRDKTDQRLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQ

TVARDVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPGQGDQEYVYLPIDSKFPLA

DYYRLEEAYETGDKDEIERCRKSLLASVKRFARDIRNKYIAPPRTTNFGVLFVPTEGLYSEIVRNPVFFDDLRREEQIIVA

GPSTLSALLNSLSVGFKTLNIQKSADHISKTIASVKTEFGKFGGILVKAQKHLQHASGNIDELLNRRTLAIERTLRHIELSE

GEPALDLLHFQENEEEYEDZ

MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEIDGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNT

PQVNQITLRLPQAGEPNDPADFKVKSPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFET

GLAYHTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIALIDSEITKTVMELGIDDT

KEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNLDASMMMMSTALALVDKGEMTNKIFAMDNRSFYKPDLDZ

MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYETQPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAID

VAFFILMVGGFLGIVNKTGALDVGLASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS

LTGVAIILLGSQIGCLASTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFVYRYADKIQKDPTKSLVYSTRKED

LKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMVLSFIPWTDLGVTIFDDFNTWLTGLPVIGNIVGSSTSALGTWYFPEG

AMLFAFMGILIGVIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGLSSQVFIVVTYIF

YLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGVLNLIAPTSGIVMGALALGRINIGTWWKFMGKLVVA

IIVVTIALLLLGTFLPFLZ

MSNSFVKLLVSQLFANLADIFFRVTIIANIYIISKSVIATSLVPILIGISSFVASLLVPLVTKRLALNRVLSLSQFGKTILLAIL

VGMFTVMQSVAPLVTYLFVVAISILDGFAAPVSYAIVPRYATDLGKANSALSMTGEAVQLIGWGLGGLLFATIGLLPTT

CINLVLYIISSFLMLFLPNAEVEVLESETNLEILLKGWKLVARNPRLRLFVSANLLEIFSNTIWVSSIILVFVTELLNKTESY

WGYSNTAYSIGIIISGLIAFRLSEKFLAAKWEPQLFTPNLKTIQNPCLSLDPGWFLFSPNGCFLLDKKEFPLYGISVEKNTK

RKETHMNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKERISKYLVTNDQRRYCRYSDSDILVQFLFQLL

TGYGTDYACKELSADAYFPKLLEGGQLASQPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTY

GKQEGVAYNAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSGFATPKLYDLIE

KTGQYYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAGSWSHKRRVCQFSERKEGNLFYDVISLVTNMTS

GTSQDQFQLYRGRGQAENFIKEMKEGFFGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFL

HVVGKCVRTGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMHZ

MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYEVLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLF

YKHYRKSKDGKWVFYLVSFLSLLPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIVIELRDGVIKDFTLWEFLRFLLFMPT

FSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMWGFLYKFILAHVLGETLLPPLKNLALQSGGFFNLYALAVMYT

FGLELFFDFAGYSMFALAISNLMGIRSPINFNKPFLSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRN

VTSSMAYIVNMLIMGFWHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVTFH

VVMLSFLIFSGFLNNLWFKKZ

MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVATTIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFD

GAHPAVLAEKYNRSYRPYLLGQGGAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTS

FLKHQSGDQASQYAATRLLQQFPNVAMKDLVQKLASKEELSTADNEMIELLARFNERQASFFGQFSVRGYVNYDKHV

AKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQIKKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSK

SKVNPIFIIPPVNKKWMNYAGLREDMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVD

PFLSNPTPAPTYHLNERFFSKDWATYDGDVKEFQZ

MEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTG

KMTQAEYKAYYTKGYHTDVTKINTTDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYV

QFSDHNVAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYYPDNLSGQEIAQEMLAHZ

MKDGHLLAHHIRLLNGRIFQKLLSQDPEALYRGEQGKILAVLWNSETGCATATDIALATGLANNTLTTMIKKLEEQKL

VIVSPCGKDKRKKYLVLTELGKSQKEVGHRVSQKLDTIFYKGFSEEEIHQFEGFQERILANLKEKGNEVZ

MTNLIATFQDRFSDWLTALSQHLQLSLLTLLLAILLAIPLAVFLRYHFKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTL

PALTALVIYAIFPILQNTITGLKGIDPNLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLAALIGAGGL

GSFILLGIDRNNASLILIGALSSAVLALAFNFLLKVMEKAKLRTIFSGFALVALLLGLSYSPALLVQKEKENLVIAGKIGPEP

EILANMYKLLIEENTSMTATVKPNFGKTSFLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQD

HLAYLKPMSYQNTYAVAVPKKLAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGLNLNVATIEPALRY

QAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMKEALLKKHPELERVLNTLAGKITESQMSQLNYQVG

VEGKSAKQVAKEFLQEQGLLKKZ

MMHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWDDLFAHRSFAQWIYLLVLGSFPLWLELVYEHRI

VDWIGMICSLTGIICVIFVSEGRASNYLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQFKKEKQEFV

ARKLDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITDATNGVGQILMTAVYREQWIFWAATNVFSIYLWWGES

LQIQGKYLIYLINSLVGWYQWSKAAKQNTDLLNZ

MRNMKAKYAVWVAFFLNLTYAIVEFLAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNREEDNQYTLGYKRFSLLG

ALVTAVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAI

VLRFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIV

HVCLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQHZ

MIEYKNVALRYTEKDVLRDVNLQIEDGEFMVLVGPSGSGKTTMLKMINRLLEPTDGNIYMDGKRIKDYDERELRLSTG

YVLQAIALFPNLTVAENIALIPEMKGWSKEETTKKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKIFL

MDEPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVANPETILKAPATDFVADLFG

GSVHDZ

MSAVAISAMTKVMQETHGNPSSIHGHGRQAGKLLREARQELAQLLRTKPQHIFFTSGGTEGNNTTHGYCLRHQEQGKH

ITTTAIEHHAVLETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFVNNETGNLLPIAEIGQILKQHPAAYH

VDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFDSYLHGGDQEQKKRAGTENLPAIVGMVAALKEDL

EKQEEHFQHVQNLETAFLAELEGIQYYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLE

AMYGANSERLKESLRLSLSPQNTVEDLQTLAKTLKEIIGGZ

MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQVESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWG

QIICLLLIQIGGLGLMTFIGVFYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQLGWGR

GLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVWFDLAGHVGRKKKGRLHFHTKLVLLLTI

GLLLFGTATTLFLEWNNAGTIGNLPVADKVLVSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLK

ITTFFVLLVFARSELLGLPHANVARRTIAPRTVQKSFSVFIIFLMSFLIGLILLGITAKGNPPFIHLVFETISALSTVGVTANL

TPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYHPEKKDMIHYMKADISIGZ

MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEPVLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESS

VLAVMHCKSLGVPTVIAKVKSQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWAG

QSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVALNSZ

MKLLSLAISSYNAAAYLHYCVESLVIGGEQVGILIINDGSQDQTQEIAECLASKYPNIVRAIYQENKCHGGAVNRGLVEAS

GRYFKVVDSDDWVDPRAYLKILETLQELESKGQEVDVFVTNFVYEKEGQSRKKSMSYDSVLPVRQIFGWDQVGNFSK

GQYTMMHSLIYRTDLLRASQFZ

MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADGLNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKP

EGVTGNTNSLPTPTERTEVSEETSPSSLDTLFEKDEEAQKNPELTDVLKETVDTADVDGTQASPAETTPEQVKGGVKEN

TKDSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKSSDNAPWSDNGTAKNPALPPLEGLTKGKYFYE

VDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGKADLTNLVATKNVDININGLVAKETVQKAVADNVKDS

IDVPAAYLEKAKGEGPFTAGVNHVIPYELFAGDGMLTRLLLKASDKAPWSDNGDAKNPALSPLGENVKTKGQYFYQV

ALDGNVAGKEKQALIDQFRANGTQTYSATVNVYGNKDGKPDLDNIVATKKVTININGLISKETVQKAVADNVKDSIDV

PAAYLEKAKGEGPFTAGVNHVIPYELFAGDGMLTRLLLKASDKAPWSDNGDAKNPALSPLGENVKTKGQYFYQLALD

GNVAGKEKQALIDQFRANGTQTYSATVNVYGNKDGKPDLDNIVATKKVTININGLISKETVQKAVADNVKTVSMFQQP

TZ

MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTIVASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFP

SNLEVQGPVEFQQLGQTFNEMSHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLATIG

RQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERRDVHLQVIPESARIEGDYAKLSRILVN

LVDNAFKYSAPGTKLEVVAKLEKDQLSISVTDEGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLALARELAHQLGG

EITVSSQYGLGSTFTLVLNLSGSENKAZ

MFGQTAQHGLTNSLKDFWIFLLNIGPQLAFFCQMLRCSRSVEQGTGNHRREFNMIQQIFSHFGMTHLGQIKLVYQESID

LELLVNALNHHLLIDRLVLTPNQITIEIDRQIVHGLDLLKGRKDKEIIDIKSMFRQLELASTQQICPINQRVHHGILAFGEIS

DLVPAKNLPNRQDZ

MEHLATYFSTYGGAFFAALGIVLAVGLSGMGSAYGVGKAGQSAAALLKEQPEKFASALILQLLPGTQGLYGFVIGILIW

LQLTPELPLEKGVAYFFVALPIAIVGYFSAKHQGNVAVAGMQILAKRPKEFMKGAILAAMVETYAILAFVVSFILTLRVZ

MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPNTVFAGFYLFDGKELVLGPFQGGVSCIRLALGKGVC

GEAAHFQETVIVGDVTTYLNYISCDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDAMDRDYLEQFVAILLEKTAWD

FTMFEEKSZ

MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKSTLSAAIMGNPNYEVTKGEVLFDGVNILELEVDERAR

MGLFLAMQYPSEIPGITNAEFLRAAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEIL

QLLMLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHVMMEGRVVLSGGPELAAR

LEREGYAKLAEELGYDYKEELZ

MPYKRQRSFSMALSKLDSLYMAVVADHSKNPHHQGKLEDAEQISLNNPTCGDVINLSVKFDAEDRLEDIAFLNSGCTIS

TASASMMTDAVLGKTKQEILELATIFSEMVQGQKDERQDQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQZ

MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTDHGYVTDFETFKEGILAREALTSTGLGDGIAMPHSKNAAVKEATV

LFAKSNKGVDYESLDGQATDLFFMIAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEEL

VQAPANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDIRKAKAIIIAADKAVEM

DRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAKAATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMI

ALAFLIDGALGVPNENLGNLGSYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIP

YAAGGEATSTLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLGTILTGFVMLAVNIPMAAINTAM

NDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAYVFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLF

KDKFTKEERNSGLTNIIMGLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNALLYLVS

VLVGAIVSGVVYGYLRKPQAZ

MANKNTSTTRRRPSKAELERKEAIQRMLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGLLIYLFFFKWIRK

QEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLTGFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGS

ILILVGSLLVSPWSVYDIAEFFSRGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETTEKALLDLPPVDMETGE

ILTEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAKEALEYKLPSLQLFAPDKPKDQSKEKKIVRE

NIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATV

SFRELWEQSQTKAENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQVKFMMVDPK

MVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFAKVGVRNIAGFNAKVEEFNSQSEYKQIPLPFIVVIVDE

LADLMMVASKEVEDAIIRLGQKARAAGIHMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRG

DMLFKPIDENHPVRLQGSFISDDDVERIVNFIKTQADADYDESFDPGEVSENEGEFSDGDAGGDPLFEEAKSLVIETQKA

SASMIQRRLSVGFNRATRLMEELEIAGVIGPAEGTKPRKVLQQZ

MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQIGALTAVFSLRESFDESVHFGTSRILGNSRGGLYALV

FFLLNTFFHEAFWVTLVVVPICTMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETILYVFVRVLETFMGVFVAIIVN

YDIDRIRLFLEKKEKZ

MNKSEHRHQLIRALITKNKIHTQAELQALLAENDIQVTQATLSRDIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELY

MEDALVWMRPVQHQVLLKTLPGLAQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEEZ

MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSVDTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRT

FSSLFYLCIACTILTTAVYILAYPLFFTDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIFLFVK

NEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVFANANMLFTFLDRLFLVKTGIDVNVSY

YTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGKGDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGIL

TSLFAFRTIILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVAPEYYLLTTMLSETSLLVFYIIFIHRKQL

IHLGHIFSYTVRYSLFSLSFVAIYFLINFVYPVDMVINLPFLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKK

SZ

MELFMKITNYEIYKKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSIL

DDCYPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAAL

QNGGKTLAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCE

RAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEFZ

MKQLTVEDAKQIELEILDYIDTLCKKHNINYIINYGTLIGAVRHEGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLS

LETDKNYFNNFIKITDSTTKIIDTRNTKTYESGIFIDIFPIDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKDWIRT

AFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKTIDLPFENLSLPAPEKFDTILTQFYGDY

MTLPPEEKRFYSHEFHAYKLEDZ

MIKINHLTTQNKDLRDLVSDLTMTIQDGEKVAIIGEEGNGKSTLLKILMGEALSDFTIKGNIQSDYQSLAYIPQKVPEDL

KKKTLHDYFFLDSIDLDYSILYRLAEELHFDSNRFASDQEIGNLSGGEALKIQLIHELAKPFEILFLDEPSNDLDLETVDW

LKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLVEHLDYDSYSEQRKANFAKQSQQAANNQRAYDKT

MEKHRRVKQNVETALRATKDSTAGRLLAKKMKTLSQEKRYEKAAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLE

KENLSIDDRVLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKLQRLLNDKREISLGFMPQDYHKKLQLDLSPIAYLSKTGE

KEELQKIQSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDLVLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVS

HDRRFLKEVCSIIYRMTEHGLKLVNLEDLZ

MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAITDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGA

GFPSLPMKILYPELDVTIIDSLNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT

IPYLKVGGKLLALKASNAPEELLEAKNALNLLESKVEDNLSYALPNRDPRYITVVEKKKETPNKYPRKAGMPNKRPLZ

MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATGRPIAGVAKLLDDLQLRDEGDYVVTFNGALVQETATG

HEIISESLTYEDYLDMEFLSRKLGVHMHAITKDGIYTANRNIGKYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPEI

LDAAIEKIPAEFYERYSINKSAPFYLELLKKNVDKGSAITHLAEKLGLTKDETMAIGDEENDRAMLEVVGNPVVMENGN

PEIKKIAKYITKTNDESGVAHAIRTWVLZ

MTWIILGVIALIVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRRNDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAA

TSPAEAMKASDALTRQVSGIFAVAESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMF

GFKAADFLQTPEEEKSVPKVDFSGLGDZ

MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFTYALSMIFQSTEIVMSMNGAREVDEQTAPD

LYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTLAV

ALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELT

RNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQMZ

MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVGKVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVES

YPVTEVFMEGATNQLDQEVLDDDLVLPIENGELDLAESVSDNILLNIPIKVLTAEEEAGQGFISGNDWQIMTEEEYQAQ

KAVKKEENSPFAGLQGLFDGDEZ

MKRQLALVVFSGGQDSTTCLFWVMQHYETVEAVTFAYGQRHHLEIQITREIAKEQGIRHHILDMSLLGQITAQPDFATI

HISYIPDKLCVESKSLKLYLFSYRNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNYGKQGTKYEGL

AEQRLFQHDLYPEKIDNRZ

MTETVEDKVSHSITGLDILKGIVAAGAVISGTVATQTKVFTNESAVLEKTVEKTDALATNDTVVLGTISTSNSASSTSLSA

SESASTSASESASTSASTSASTSASESASTSASTSISASSTVVGSQTAAATEATAKKVEEDRKKPASDYVASVTNVNLQSYA

KRRKRSVDSIEQLLASIKNAAVFSGNTIVNGAPAINASLNIAKSETKVYTGEGVDSVYRVPIYYKLKVTNDGSKLTFTYT

VTYVNPKTNDLGNISSMRPGYSIYNSGTSTQTMLTLGSDLGKPSGVKNYITDKNGRQVLSYNTSTMTTQGSGYTWGNG

AQMNGFFAKKGYGLTSSWTVPITGTDTSFTFTPYAARTDRIGINYFNGGGKVVESSTTSQSLSQSKSLSVSASQSASASAS

TSASASASTSASASASTSASASASTSASVSASTSASASASTSASASASTSASESASTSASASASTSASASASTSASASASTSASE

SASTSASASASTSASESASTSASASASTSASASASTSASGSASTSTSASASTSASASASTSASASASISASESASTSASESASTST

SASASTSASESASTSASASASTSASASASTSASASASTSASASTSASESASTSASASASTSASASASTSASASASTSASASASTS

ASVSASTSASASASTSASASASTSASESASTSASASASTSASASASTSASASASTSASESASTSASASASTSASESASTSASASA

STSASASASTSASGSASTSTSASASTSASASASTSASASASISASESASTSASESASTSTSASASTSASESASTSASASASTSASA

SASTSASASARQVRRPQPVHLNRHQPVRQPQQVLVHQLQHQRVHRLQHQPVPRLQRQPVRQLQQVPVLQSQHQQVLQ

PQHRQVPRLQQAHQHLNQRRQAPQLQQVPVRQPQRRQVRQPQQVLVHQLQHQRVHRLRRQPVHQSQQVPVRQLPHQ

QVPRLQQAPVRRLQQVLAPQPQPQPVRQPQQVSQRLNRHQRVRPLQQVLAPQPQRQQVHRLQRQRVRLNRHQRVRPL

QQVLAPQPQRQQVHRLQHQRVRPLQQVLAPQPQRQQVHRLQRQRVRLSQHQRVRQPQQAHQLLNLHQPVRQPQHRQ

APQLQQVPVRQPQRRQVRRLQQVPVRQPQQVPVRQPQRRQVRRPQPVHLNRHQPVRQPQQVLVHQLQHQRVHRLQH

QPVHQSQQVPVRQFRINKCLGFSKYZ

MGVETWFYSSICWLAIGLGSVWKFPYMTAANGGGGFLLIFLISTILIGFPLLLAEFALGRSAGVSAIKTFGKLGKNNKYN

FIGWIGAFALFILLSFYSVIGGWILVYLGIEFGKLFQLGGTGDYAQLFTSIISNPAIALGAQAAFILLNIFIVSRGVQKGIERA

SKVMMPLLFIVFVFIIGRSLSLPNAMEGVLYFLKPDFSKLTSTGLLYALGQSFFALSLGVTVMLTYASYLDKKTNLVQSG

ISIVAMNISISIMAGLAIFQARSPFNIQSEGGPSLLFIVVLPQLFDKMPFGTIFYVLFLLLFLFATVTFSVVMLEINVDNITNQD

NSKRAKWSVILGILTFVFGIPSALSYGVMADVHIFGKTFFDAMDFLVSNLLMPFGALYLSLFTGYIFKKALAMEELHLD

ERAWKQGLFQVWLFLLRFFVSSFQSSSLWSSLPNLCNQKGLEZ

MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQAFANEILFGLWCMAAPIAAIFVPRVGSATIGEVLAA

LAEVLYGSQFGLGALLSGFVQGLGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRISV

YFFCTILVRAIVKLYHQFATGGKAZ

MVKVATQTPIISLFLLILSLETSFIPSIALTLSVVAFCILFMLYYRRFKMLAWMIILAILPSFANYWAVQLHGDASQAVML

GTRAFVTVCIGLVFVSSVSLKELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKVLM

TVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFLZ

MRKHQLQVHKLTILSMMIALDVVLTPIFRIEGMAPMSSVVNILAGIMMGPVYALAMATVTAFIRMTTQGIPPLALTGAT

FGALLAGLFYKYGRKFHYSALG?EILGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEFFK

KVQGYFFSERIDZ

MQEFTNPFPIGSSSLIHCITNEISCEMLANGILALGCKPVMADDSREVLDFTKQSQALFINLGHLSAEKEKAIRMAASYAN

QSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYP

GMSFLVTGPKDLVVSKNQVAVLGNGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMG

LEEFRYQVLNQLSLLRRDENWLDTIKGEVYEZ

MNHKIAILSDVHGNATALEAVIADAKNQGASEYWLLGDIFLPGPGANDLVALLKDLPITASVRGNWDDRVLEALDGQ

YGLEDPQEVQLLRMTQYLMERMDPATIVWLRSLPLLEKKEIDGLRFSISHNLPDKNYGGDLLVENDTEKFDQLLDAET

DVAVYGHVHKQLLRYGSQGQQIINPGSIGMPYFNWEALKNHRSQYAVIEVEDGELLNIQFRKVAYDYEAELELAKSKG

LPFIEMYEELRRDDNYQGHNLELLASLIEKHGYVEDVKNFFDFLZ

MNVNQIVRIIPTLKANNRKLNETFRYETLGMKALLEESAFLSLGDQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVE

NPLEIEGILSKTDSIHRLYKGQNGYAFEIFSPEDDLILIHAEDDIASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDIESF

LESSEIGASLDFIPAQGQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFESTEYFIPKSEKFFLGKDRNNVELWFEEVZ

MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSDPEHGLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLD

IDRLVIDFLPESDYPDITIRQLLTHATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDLD

VILKDQVWKPWGMTETKFGPVELAVPTVRGVEAGIVHDPKARLLGRHAGSAGLFSTIKDLQIFLEHYLADDFARDLNQ

NFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQKQEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEEZ

MMKKTYNHILVWGVIFYSICIVCFCFTPQEQSTVGVGTPGIQHLGRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNILNV

FLFFPLIFQLLYLFPNLRKTKKVLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKVRN

Z

MKIPLLTFARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDLAKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIII

VLLGFQYIELKNKVLRLSIGREVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIITYFFGTFSPLGWNSLFSDGSGLQRLLDGE

IKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAITYLMFLWLGSMLLYSALPYYMVPMTSLMQASYGDVSLMKLFTP

YILYIVPYMVLEKYEDNVZ

MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPILDNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKR

DKGTAALAGVTGYLVMTATIKALVKLFMAEGSAIDTGVIGALVVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTSF

SSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPMFWYTELGGVETVAGQTVVGAQKIF

FAQLADLAHSGLFTEGTRFFAGRFSTMMFGLPAACLAMYHSVPKNRRKKYAGLFFGVALTSFITGITEPIEFMFLFVSPV

LYVVHAFLDGVSFFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPFGLIWSVLYYIIFRWFITQFNVLTPGRGE

EVDSKEISESADSTSNTADYLKQDSLQIIRALGGSNNIEDVDACVTRLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQ

AIYGAKAILYKNSINEILGVDDZ

MKFRKLACTVLAGAAVLGLAACGNSGGSKDAAKSGGDGAKTEITWWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDI

KVKLETIDFKSGPEKITTAIEAGTAPDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPI

SSAPFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGTRAFISNLYSGSVTDEKV

SKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNFANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSD

EGKPALEYLVNGFAVFNNKDDKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP

YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQZ

MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPDTIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFI

SLVTMFLVCATSSLAGYVLAKKRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM

KQFSENIPTELLESAKIDGCGEIPTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRNNLTISLGVATMQAEMA

TNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGAVKGZ

MKIMFKNFNNILLNRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFFKRELISIFSYNDYSEANLEIPKLLLNLSLFMVGW

LSVILLESDLADHYHHLIRYQSSSFFDYTRKRLVVISKFFTQDLFVWFLGLLPLGIHFKTVALFFLLAQLMMLYLLLSYLI

ALISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLVLLSLLVMLIVSRLEEKFKKGZ

MGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKGSIESMHNLPVNLAG

ARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKKDYTYKAPLAQQALPETGNKESDLLASLG

LTAFFLGLFTLGKKREQZ

MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEFRQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKI

QAAKNGAELADVTSEVTEEADGYTVRVYNPGQEGDIVEVDLVWNLKNLLFLYDDIAELNWQPLTDSSESIEKFEFHVR

GDKGAEKLFFHTGKLFREGTIEKSNLDYTIRLDNLPAKRGVELHAYWPRTDFASARDQGLKGNRLEEFNKIEDSIVREK

DQSKQLVTWVLPSILSISLLLSVCFYFIYRRKTTPSVKYAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTF

DQLIQATLLDVIDRGNVSIISEGDAVGLRLVKEDGLSSFEKDCLNLAFSGKKEETLSNLFADYKVSDSLYRRAKVSDEKR

IQARGLQLKSSFEEVLNQMQEGVRKRVSFWGLPDYYRPLTGGEKALQVGMGALTILPLFIGFGLFLYSLDVHGYLYLPL

PILGFLGLVLSVFYYWKLRLDNRDGVLNEAGAEVYYLWTSFENMLRELARLDQAELESIVVWNRLLVYATLFGYADK

VSHLMKVHQIQVENPDINLYVAYGWHSTFYHSTAQMSHYASVANTASTYSVSSGSGSSGGGFSGGGGGGSIGAFZ

MKKVRKIFQKAVAGLCCISQLTAFSSIVALAETPETSPAIGKVVIKETGEGGALLGDAVFELKNNTDGTTVSQRTEAQTG

EAIFSNIKPGTYTLTEAQPPVGYKPSTKQWTVEVEKNGRTTVQGEQVENREEALSDQYPQTGTYPDVQTPYQIIKVDGS

EKNGQHKALNPNPYERVIPEGTLSKRIYQVNNLDDNQYGIELTVSGKTVYEQKDKSVPLDVVILLDNSNSMSNIRNKNA

RRAERAGEATRSLIDKITSDSENRVALVTYASTIFDGTEFTVEKGVADKNGKRLNDSLFWNYDQTSFTTNTKDYSYLKL

TNDKNDIVELKNKVPTEAEDHDGNRLMYQFGATFTQKALMKADEILTQQARQNSQKVIFHITDGVPTMSYPINFNHAT

FAPSYQNQLNAFFSKSPNKDGILLSDFITQATSGEHTIVRGDGQSYQMFTDKTVYEKGAPAAFPVKPEKYSEMKMGYA

VIGDPINGGYIWLNWRESILAYPFNSNTAKITNHGDPTRWYYNGNIAPDGYDVFTVGIGINGDPGTDEATATSFMQSISS

KPENYTNVTDTTKILEQLNRYFHTIVTEKKSIENGTITDPMGELIDLQLGTDGRFDPADYTLTANDGSRLENGQAVGGP

QNDGGLLKNAKVLYDTTEKRIRVTGLYLGTDEKVTLTYNVRLNDEFVSNKFYDTNGRTTLHPKEVEQNTVRDFPIPKI

RDVRKYPEITISKEKKLGDIEFIKVNKNDKKPLRGAVFSLQKQHPDYPDIYGAIDQNGTYQNVRTGEDGKLTFKNLSDG

KYRLFENSEPAGYKPVQNKPIVAFQIVNGEVRDVTSIVPQDIPAGYEFTNDKHYITNEPIPPKREYPRTGGIGMLPFYLIG

CMMMGGVLLYTRKHPZ

MKSINKFLTMLAALLLTASSLFSAATVFAAGTTTTSVTVHKLLATDGDMDKIANELETGNYAGNKVGVLPANAKEIAG

VMFVWTNTNNEIIDENGQTLGVNIDPQTFKLSGAMPATAMKKLTEAEGAKFNTANLPAAKYKIYEIHSLSTYVGEDGA

TLTGSKAVPIEIELPLNDVVDAHVYPKNTEAKPKIDKDFKGKANPDTPRVDKDTPVNHQVGDVVEYEIVTKIPALANYA

TANWSDRMTEGLAFNKGTVKVTVDDVALEAGDYALTEVATGFDLKLTDAGLAKVNDQNAEKTVKITYSATLNDKAI

VEVPESNDVTFNYGNNPDHGNTPKPNKPNENGDLTLTKTWVDATGAPIPAGAEATFDLVNAQTGKVVQTVTLTTDKN

TVTVNGLDKNTEYKFVERSIKGYSADYQEITTAGEIAVKNWKDENPKPLDPTEPKVVTYGKKFVKVNDKDNRLAGAEF

VLANADNAGQYLARKADKVSQEEKQLVVTTKDALDRAVAAYNALTAQQQTQQEKEKVDKAQAAYNAAVIAANNAF

EWVADKDNENVVKLVSDAQGRFEITGLLAGTYYLEETKQPAGYALLTSRQKFEVTATSYSATGQGIEYTAGSGKDDAT

KVVNKKITIPQTGGIGTIIFAVAGAAIMGIAVYAYVKNNKDEDQLAZ

MTMQKMQKMISRIFFVMALCFSLVWGAHAVQAQEDHTLVLQLENYQEVVSQLPSRDGHRLQVWKLDDSYSYDDRV

QIVRDLHSWDENKLSSFKKTSFEMTFLENQIEVSHIPNGLYYVRSIIQTDAVSYPAEFLFEMTDQTVEPLVIVAKKTDTM

TTKVKLIKVDQDHNRLEGVGFKLVSVARDVSEKEVPLIGEYRYSSSGQVGRTLYTDKNGEIFVTNLPLGNYRFKEVEPL

AGYAVTTLDTDVQLVDHQLVTTTVVNQKLPRGNVDFMKVDGRTNTSLQGAMFKVMKEESGHYTPVLQNGKEVVVTS

GKDGRFRVEGLEYGTYYLWELQAPTGYVQLTSPVSFTIGKDTRKELVTVVKNNKRPRIDVPDTGEETLVYLDACCHFV

VWZ

MSHIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQDDDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKE

PLVVKTKWEGLVPALTSGKIDMIIAGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYL

YNLIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGFKTGEEDTAIAIGLRKNDNR

ISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSSSFFSQVAKILSENWQQLLRGAGTTLLISIVGTIIGLIIGLAIGVFR

TAPLSENKVIYGLQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYMTEIVRGGILAV

DKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTIIAV

IYFVLTFTVTRILRFIERRMDMDTYTTGANQMQTEDLKZ

MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGKSTFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREK

LGMVFQSFNLFENLNVLENTIVAQTTVLKRERTEAEKIAKENLEKVGMGERYWQAKPKQLSGGQKQRVAIARALSMN

PDAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGVIAEEGKPEDLFTNPKEDRTK

EFLQRYLKZ

MKKYQLLFKISAVFSYLFFVFSLSQLTLIVQNYWQFSSQIGNLFWIQNILSLLFIGVMIVVLVKTGHGYLFRIPRKKWLW

YSILTVLVLVFQISFNVQTAKHVQSTAEGWAVLIGYSGTNFAELGIYIALFFLVPLMEELIYRGLLQHAFFKHSRFGLDLL

LPSILFALPHFSSLPSLLDIFVFATVGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLTFLHRVLGZ

MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVTDTGGVDDKSFNQSAWEGLQAWGKEHNLSKDN

GFTYFQSTSEADYANNLQQAAGSYNLIFGVGFALNNAVKDAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLA

GVAAAKTTKTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQYAAGADIVYQVAG

GTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKESNFVLVSTLKQVGTTVKDISNKAERGEFPGGQV

IVYSLKDKGVDLAVTNLSEEGKKAVEDAKAKILDGSVKVPEKZ

MSKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTAFGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGL

PGQALAGWILSGWFALSHPDMPRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFPKD

FMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGFEIRAVGLNPHASEYAGISAKRTIIL

SMIISGALAGLGGAVEGLGTFQNVYVQGSSLAIGFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSI

VTASIIFFVSVHYLIERFVKPKKQVKGGKZ

MGVKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYFFAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQ

MVASRKMQEAQPRIKALREQYPGRDMESTKKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGH

FLWINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAPGGVALYWTVSNAYQVLQTY

FLNNPFKILAEREAVVQAQKDLENRKRKKKKAQKTKZ

MVIDPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKERIIVVKPGDTIELKDMKIH

AVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKAVNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNN

YGENPVGIQDKMTSIDLLRMAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQD

QHLVEYHHPRGFDDCFEQDSNIQFKALLZ

MFLSGWLSSFANTYIHDLLGVLFPDSPFLNAFESAIAAPLVEEPLKLLSLVFVLALIPVRKLKSLFLLGIASGLGFQMIKDI

GYIRTDLPEGFDFTISILERIISGIASHWTFSGLAVVGVYLLYRAYKGQKVGKKQGLIFLGLALGTHFLFNSPFVELETEL

PLAIPVVTAIALYGFYHAYCFVEKHNELMTZ

MKVEPRCDVLSRMSHFFIRILIMELQELVERSWAIRQAYHELEVKHHDSKWTVEEDLLALSNDIGNFQRLVMTKQGRY

YDETPYTLEQKLSENIWWLLELSQRLDIDILTEMENFLSDKEKQLNVRTWKZ

MLDWKQFFLAYLRSRSRLFIYLLSLAFLVLLFQFLFASLGIYFLYFFFLCCFVTILFFTWDILVETQVYRQELLYGEREAK

SPLEIALAEKLEAREMELYQQRSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNLV

LQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGGLEIY

MDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVL

EZ

MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINTMLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVP

GYGYARVSKKEREKWGCMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKH

ESAIKKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKLZ

MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPKFLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDEL

ENQDGLDFKILFLDAADKELVARYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQF

SDQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVMNHPESEDFYQHLLALIEPILP

SYQKEGKSVLTIAMGCTGGQHRSVAFAKRLAQDLSKNWSVNEGHRDKDRRKETVNRSZ

MRKPKITVIGGGTGSPVILKSLREKDVEIAAIVTVADDGGSSGELRKNMQQLTPPGDLRNVLVAMSDMPKFYEKVFQYR

FSEDAGAFAGHPLGNLIIAGLSEMQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVAGESHIVDHRGIIDN

VYVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEIAYVCNIMTQRGETEHFTDSDHV

EVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYLVQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMR

I

IQVKKZ

MKNLIKLLIIRLIVNLADSVFYIVALWHVSNNYSSSMFLGIFIAVNYLPDLLLIFFGPVIDRVNPQKILIISILVQLAVAVIFL

LLLNQISFWVIMSLVFISVMASSISYVIEDVLIPQVVEYDKIVFANSLFSISYKVLDSIFNSFASFLQVAVGFILLVKIDIGIFL

LALFILLLLKFRTSNANIENFSFKYYKREVLQGTKFILNNKLLFKTSISLTLINFFYSFQTVVVPIFSIRYFDGPIFYGIFLTIA

GLGGILGNMLAPIVIKYLKSNQIVGVFLFLNGSSWLVAIVIKDYTLSLILFFVCFMSKGVFNIIFNSLYQQIPPHQLLGRVN

TTIDSIISFGMPIGSLVAGTLIDLNIELVLLAISIPYFLFSYIFYTDNGLKEFSIYZ

MMSNKNKEILIFAILYTVLFMFDGVKLLASLMPSAIANYLVYVVLALYGSFLFKDRLIQQWKEIRKTKRKFFFGVLTGW

LFLILMTVVFEFVSEMLKQFVGLDGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLSGLLSIILV

GLVFALTHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLIILAISIVKZ

LKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGSGKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVH

TVFQSYALFPHMNVFENVAFPLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVLLD

EPLSALDLKLRTDMQYELRELQQRLGTTFVFVTHDQEEALAMSDWIFVMNDGEIVQSGTPVDIYDEPINHFVATFIGESN

ILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEVVIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMI

HSTRKAIVGEEIGLDFEPEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKLZ

MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLIN

LLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKTVLTILATLLFLRNPMTIVSL

LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFFZ

MVKKIIGMVLALLSVTVVGVGVFAYITYQQGTETLAKTYKKIGEETKVIEATEPLTILLMGVDTGNVERTETWVGRSDS

MILMTVNPKTKKTTMMSLERDILTRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLV

DAVGGITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVIQKVMEKALSLNSIGH

YQEILKALSDNMQTNIDISAKSIPNLLGYKDSFKTIETQQLQGEGEILQGVSYQIVSRAHMLEMQNLLRRSLGQEEVTQL

ETNAVLFEDLFGRAPVGDEDNZ

MKKQAYVILALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEKFVFLLLVFSMSMTCLLALFWRGIEELSLRKMQANLK

RLLAGQEVVQVADPDLDASFKSLSGKLNLLTEALQKAENQSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ

QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLRVSLKQNMTKLPKKIEEHI

FRILQELISNTLRHAQASCLDVYLYQTDVELQLKVVDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLA

VDIRIPLLDKEZ

MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVAVTLITKKGVNPFLATLVAVGAGCLAGMAAGLLYTKGK

IPTLLSGILVMTSCHSIMLLIMGRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDNP

DMARSFGIHTGRMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLIIGEVIFKSLSLAERLVTTVVGSLAY

QFLVWAVLALGFNTSYLRLYSALILAVCLMIPTFKQTILKGAKLSKZ

MKKMKVWSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQELVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIAG

AQLADRVIAEKNNAVADMVFGIGAVDSNKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDVKEMP

KDWTELGSKYKGKYSISGLQGGTGRAILASILVRYLDDKGELGVSEKGWEVAKEYLKNAYTLQKGESSIVKMLDKEDPI

QYGMMWGSGALVGQKEQNVVFKVMTPEIGVPFVTEQTMVLSTSKKQALAKEFIDWFGQSEIQVEYSKNFGSIPANKD

ALKDLPEDTKKFVDQVKPQNIDWEAVGKHLDEWVEKAELEYVQZ

MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTLRALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSY

ALFPTMTVFDNIAFGLKVKKVAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPLS

NLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPVEIYHNSQTEFVCDFIGDINVLTD

ETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQDFILKGTIIDVEFSGVTIHYTIKVSESQILNVTSIDSQAAIRSVGESV

ELFITPSDVLQFZ

MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSLDAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGIL

CVLFTEYFDIKGAKILKLGYMTSLIYGGVVLATGYKFVYGPYGLTTKKFLQNVIPSLDPNWFIGYGAVLFIMTFSGTANHT

LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAAPMIVGGKEFQTINPMIITFAGMG

NSRDLAALLAIILGIATTILLTIMNKIEKGGNYISISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPV

AIQTGNLTLSNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKSRFDFLFEYGALLPWLLPSTLLA

VSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVRAILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLS

VIALNFNSLLTDFDLSVFLYHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRKZ

Table 3

ID201-4106.4

ATGATAAAAAATCCTAAATTATTAACCAAGTCTTTTTTAAGAAGTTTTGCAATTCTAGGTGGTGTTGGTCTAGTCAT

TCATATAGCTATTTATTTGACCTTTCCTTTTTATTATATTCAACTGGAGGGGGAAAAGTTTAATGAGAGCGCAAGAG

TGTTTACGGAGTATTTAAAGACTAAGACATCTGATGAAATTCCAAGCTTACTCCAGTCTTATTCAAAGTCCTTGACC

ATATCTGCTCACCTTAAAAGAGATATTGTAGATAAGCGGCTCCCTCTTGTGCATGACTTGGATATTAAAGATGGAAA

GCTATCAAATTATATCGTGATGTTAGATATGTCTGTTAGTACAGCAGATGGTAAACAGGTAACCGTGCAATTTGTTC

ACGGGGTGGATGTCTACAAAGAAGCAAAGAATATTTTGCTTTTGTATCTCCCATATACATTTTTGGTTACAATTGCT

TTTTCCTTTGTTTTTTCTTATTTTTATACTAAACGCTTGCTCAATCCTCTTTTTTACATTTCAGAAGTGACTAGTAA

AATGCAAGATTTGGATGACAATATTCGTTTTGATGAAAGTAGGAAAGATGAAGTTGGTGAAGTTGGAAAACAGATTA

ATGGTATGTATGAGCACTTGTTGAAGGTTATTTATGAGTTGGAAAGTCGTAATGAGCAAATTGTAAAATTGCAAAAT

CAAAAGGTTTCCTTTGTCCGCGGAGCATCACATGAGTTGAAAACCCCTTTAGCCAGTCTTAGAATTATCCTAGAGAA

TATGCAGCATAATATTGGAGATTACAAAGATCATCCAAAATATATTGCAAAGAGTATAAATAAGATTGACCAGATGA

GCCACTTATTAGAAGAAGTACTGGAGTCTTCTAAATTCCAAGAGTGGACAGAGTGTCGTGAGACCTTGACTGTTAAG

CCAGTTTTAGTAGATATTTTATCACGTTATCAAGAATTAGCTCATTCAATAGGTGTTACAATTGAAAATCAATTGAC

AGATGCTACCAGGGTCGTCATGAGTCTTAGGGCATTGGATAAGGTTTTGACAAACCTGATTAGTAATGCAATTAAAT

ATTCAGATAAAAATGGGCGTGTAATCATATCCGAGCAAGATGGCTATCTCTCTATCAAAAATACATGTGCGCCTCTA

AGTGACCAAGAACTAGAACATTTATTTGATATATTCTATCATTCTCAAATCGTGACAGATAAGGATGAAAGTTCCGG

TTTGGGTCTTTACATTGTGAATAATATTTTAGAAAGCTATCAAATGGATTATAGTTTTCTCCCTTATGAACACGGTA

TGGAATTTAAGATTAGCTTGTAG

MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGEKFNESARVFTEYLKTKTSDEIPSLLQSYSKSLT

ISAHLKRDIVDKRLPLVHDLDIKDGKLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIA

FSFVFSYFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIYELESRNEQIVKLQN

QKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIAKSINKIDQMSHLLEEVLESSKFQEWTECRETLTVK

PVLVDILSRYQELAHSIGVTIENQLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSTKNTCAPL

SDQELEHLFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISLZ

ID202-4106.9

ATGGATAAAATTATTAAAACTATATCAGAAAGCGGAGCCTTTCGTGCTTTTGTCCTTGATAGCACTGAAACCGTCCG

CACTGCTCAAGAAAAACATCAAACCCAAGCTAGCTCAACTGTAGCGCTTGGTCGAACTCTTATCGCTAGCCAGATTC

TCGCAGCCAATGAAAAAGGAAATACCAAACTTACAGTTAAGGTGTTGGGATCTAGCTCTCTAGGTGCTATTATCACC

GTCGCTGATACCAAGGGGAACGTCAAAGGCTATGTTCAAAATCCTGGTGTTGACATCAAAAAGACTGCGACTGGTGA

AGTCCTAGTCGGACCTTTTGTTGGAAATGGTCAATTCCTCGTTATCACAGACTACGGTACTGGAAATCCTTACAACT

CTATAACTCCCCTCATCTCTGGAGAAATCGGTGAAGACCTTGCCTTTTACCTTACTGAAAGCCAACAAACGCCTTCA

GCGGTCGGCCTCAATGTCCTTTTGGACGAGGAAGACAAGGTCAAGGTTGCAGGTGGTTTCCTAGTTCAAGTCTTGCC

AGGAGCCAAGAAAGAAGAGATTGCTCGCTTTGAAAAACGCATCCAAGAAATGCCAGCTATCTCTACTCTTCTCGAAA

GCGACGACCATATCGAAGCCCTCCTCAAGGCTATCTACGGGGACGAAGCCTACAAGCGTCTTTCTGAAGAAGAAATC

CGTTTCCAATGTGACTGTAGCCATGAACGCTTTATGAACGCTCTTGCCAGCCTTCCAAGCTCAGACTTACAGGAAAT

GAAAGAGGAAGACCACGGGGCAGAAATCACTTGTCAATTCTGCCAAACTACTTACAACTTTGATGAAAAGGACCTGG

AGGAACTCATTCGTGACAAATCTTAA

MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGRTLIASQILAANEKGNTKLTVKVLGSSSLGAIIT

VADTKGNVKGYVQNPGVDIKKTATGEVLVGPFVGNGQFLVTTDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPS

AVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEI

RFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYNFDEKDLEELIRDKSZ

ID203-4115

ATGAAATCAATAACTAAAAAGATTAAAGCAACTCTTGCAGGAGTAGCTGCCTTGTTTGCAGTATTTGCTCCATCATT

TGTATCTGCTCAAGAATCATCAACTTACACTGTTAAAGAAGGTGATACACTTTCAGAAATCGCTGAAACTCACAACA

CAACAGTTGAAAAATTGGCAGAAAACAACCACATTGATAACATTCATTTGATTTATGTTGATCAAGAGTTGGTTATC

GATGGCCCTGTAGCGCCTGTTGCAACACCAGCGCCAGCTACTTATGCGGCACCAGCCGCTCAAGATGAAACTGTTTC

AGCTCCAGTAGCAGAAACTCCAGTAGTAAGTGAAACAGTTGTTTCAACTGTAAGCGGATCTGAAGCAGAAGCCAAAG

AATGGATCGCTCAAAAAGAATCAGGTGGTAGTATACAGCTACAAATGGACGTTATATCGGACGTTACCAATTAA

MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVDQELVI

DGPVAPVATPAPATYAAPAAQDETVSAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSIQLQMDVISDVTNZ

ID204-4117.1

ATGAATTTAGGAGAATTTTGGTACAATAAAATAAATAAGAACAGAGGAAGAAGGTTAATGAAGAAAGTAAGATTTAT

TTTTTTAGCTCTGCTATTTTTCTTAGCTAGTCCAGAGGGTGCAATGGCTAGTGATGGTACTTGGCAAGGAAAACAGT

ATCTGAAAGAAGATGGCAGTCAAGCAGCAAATGAGTGGGTTTTTGATACTCATTATCAATCTTGGTTCTATATAAAA

GCAGATGCTAACTATGCTGAAAATGAATGGCTAAAGCAAGGTGACGACTATTTTTACCTCAAATCTGGTGGCTATAT

GGCCAAATCAGAATGGGTAGAAGACAAGGGAGCCTTTTATTATCTTGACCAAGATGGAAAGATGAAAAGAAATGCTT

GGGTAGGAACTTCCTATGTTGGTGCAACAGGTGCCAAAGTAATAGAAGACTGGGTCTATGATTCTCAATACGATGCT

TGGTTTTATATCAAAGCAGATGGACAGCACGCAGAGAAAGAATGGCTCCAAATTAAAGGGAAGGACTATTATTTCAA

ATCCGGTGGTTATCTACTGACAAGTCAGTGGATTAATCAAGCTTATGTGAATGCTAGTGGTGCCAAAGTACAGCAAG

GTTGGCTTTTTGACAAACAATACCAATCTTGGTTTTACATCAAAGAAAATGGAAACTATGCTGATAAAGAATGGATT

TTCGAGAATGGTCACTATTATTATCTAAAATCCGGTGGCTACATGGCAGCCAATGAATGGATTTGGGATAAGGAATC

TTGGTTTTATCTCAAATTTGATGGGAAAATGGCTGAAAAAGAATGGGTCTACGATTCTCATAGTCAAGCTTGGTACT

ACTTCAAATCCGGTGGTTACATGACAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTTTTATCTCAAATCTGAT

GGGAAAATAGCTGAAAAAGAATGGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTCAAATCCGGTGGTTACAT

GACAGCCAATGAATGGATTTGGGATAAGGAATCTTGGTTTTACCTCAAATCTGATGGGAAAATAGCTGAAAAAGAAT

GGGTCTACGATTCTCATAGTCAAGCTTGGTACTACTTCAAATCTGGTGGCTACATGGCGAAAAATGAGACAGTAGAT

GGTTATCAGCTTGGAAGCGATGGTAAATGGCTTGGAGGAAAAACTACAAATGAAAATGCTGCTTACTATCAAGTAGT

GCCTGTTACAGCCAATGTTTATGATTCAGATGGTGAAAAGCTTTCCTATATATCGCAAGGTAGTGTCGTATGGCTAG

ATAAGGATAGAAAAAGTGATGACAAGCGCTTGGCTATTACTATTTCTGGTTTGTCAGGCTATATGAAAACAGAAGAT

TTACAAGCGCTAGATGCTAGTAAGGACTTTATCCCTTATTATGAGAGTGATGGCCACCGTTTTTATCACTATGTGGC

TCAGAATGCTAGTATCCCAGTAGCTTCTCATCTTTCTGATATGGAAGTAGGCAAGAAATATTATTCGGCAGATGGCC

TGCATTTTGATGGTTTTAAGCTTGAGAATCCCTTCCTTTTCAAAGATTTAACAGAGGCTACAAACTACAGTGCTGAA

GAATTGGATAAGGTATTTAGTTTGCTAAACATTAACAATAGCCTTTTGGAGAACAAGGGCGCTACTTTTAAGGAAGC

CGAAGAACATTACCATATCAATGCTCTTTATCTCCTTGCCCATAGTGCCCTAGAAAGTAACTGGGGAAGAAGTAAAA

TTGCCAAAGATAAGAATAATTTCTTTGGCATTACAGCCTATGATACGACCCCTTACCTTTCTGCTAAGACATTTGAT

GATGTGGATAAGGGAATTTTAGGTGCAACCAAGTGGATTAAGGAAAATTATATCGATAGGGGAAGAACTTTCCTTGG

AAACAAGGCTTCTGGTATGAATGTGGAATATGCTTCAGACCCTTATTGGGGCGAAAAAATTGCTAGTGTGATGATGA

AAATCAATGAGAAGCTAGGTGGCAAAGATTAG

MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASDGTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIK

ADANYAENEWLKQGDDYFYLKSGGYMAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDA

WFYIKADGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFYIKENGNYADKEWI

FENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSD

GKIAEKEWVYDSHSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYMAKNETVD

GYQLGSDGKWLGGKTTNENAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAITISGLSGYMKTED

LQALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKYYSADGLHFDGFKLENPFLFKDLTEATNYSAE

ELDKVFSLLNINNSLLENKGATFKEAEEHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFD

DVDKGILGATKWIKENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKDZ

ID205-4118.1

ATGAAAAAATTAGGTACATTACTCGTTCTCTTTCTTTCTGCAATCATTCTTGTAGCATGTGCTAGCGGAAAAAAAGA

TACAACTTCTGGTCAAAAACTAAAAGTTGTTGCTACAAACTCAATCATCGCTGATATTACTAAAAATATTGCTGGTG

ACAAAATTGACCTTCATAGTATCGTTCCGATTGGGCAAGACCCACACGAATACGAACCACTTCCTGAAGACGTTAAG

AAAACTTCTGAGGCTAATTTGATTTTCTATAACGGTATCAACCTTGAAACAGGTGGCAATGCTTGGTTTACAAAATT

GGTAGAAAATGCCAAGAAAACTGAAAACAAAGACTACTTCGCAGTCAGCGACGGCGTTGATGTTATCTACCTTGAAG

GTCAAAATGAAAAAGGAAAAGAAGACCCACACGCTTGGCTTAACCTTGAAAACGGTATTATTTTTGCTAAAAATATC

GCCAAACAATTGAGCGCCAAAGACCCTAACAATAAAGAATTCTATGAAAAAAATCTCAAAGAATATACTGATAAGTT

AGACAAACTTGATAAAGAAAGTAAGGATAAATTTAATAAGATCCCTGCTGAAAAGAAACTCATTGTAACCAGCGAAG

GAGCATTCAAATACTTCTCTAAAGCCTATGGTGTCCCAAGTGCTTACATCTGGGAAATCAATACTGAAGAAGAAGGA

ACTCCTGAACAAATCAAGACCTTGGTTGAAAAACTTCGCCAAACAAAAGTTCCATCACTCTTTGTAGAATCAAGTGT

GGATGACCGTCCAATGAAAACTGTTTCTCAAGACACAAACATCCCAATCTACGCTCAAATCTTTACTGACTCTATCG

CAGAACAAGGTAAAGAAGGCGACAGCTACTACAGCATGATGAAATACAACCTTGACAAGATTGCTGAAGGATTGGCA

AAATAA

MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVK

KTSEANLIFYNGINLETGGNAWFTKLVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNI

AKQLSAKDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWEINTEEEG

TPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLA

KZ

ID206-4119.1

ATGGAATGGTATAAAAAAATCGGACTTCTTGCAACTACAGGTTTAGCTTTGTTTGGGCTCGGCGCTTGCTCCAACTA

TGGTAAATCTGCGGATGGCACAGTGACCATCGAGTATTTCAACCAGAAAAAAGAAATGACCAAAACCTTGGAAGAAA

TCACTCGTGATTTTGAGAAGGAAAACCCTAAGATCAAGGTCAAAGTCGTCAATGTACCAAATGCTGGTGAAGTATTG

AAGACACGCGTTCTCGCAGGAGATGTGCCTGATGTGGTCAATATTTACCCACAGTCCATCGAACTGCAAGAATGGGC

AAAAGCAGGTGTTTTTGAAGATTTGAGCAACAAAGACTACCTGAA?CGCGTGAAAAATGGCTACGCTGAAAAATATG

CTGTAAACGAAAAAGTTTACAACGTTCCTTTTACAGCTAATGCTTATGGAATTTACTACAACAAAGATAAATTCGAA

GAACTGGGCTTGAAGGTTCCTGAAACCTGGGATGAATTTGAACAGTTAGTCAAAGATATCGTTGCTAAAGGACAAAC

ACCATTTGGAATTGCAGGTGCAGATGCTTGGACACTCAATGGTTACAATCAATTAGCCTTTGCGACAGCAACAGGTG

GAGGAAAAGAAGCAAATCAATACCTTCGTTATTCTCAAC?AAATGCCATTAAATTGTCGGATCCGATTATGAAAGAT

GATATCAAGGTCATGGACATCCTTCGCATCAATGGATCTAAGCAAAAGAACTGGGAAGGTGCTGGCTATACCGATGT

TATCGGAGCCTTCGCACGTGGGGATGTCCTCATGACACCAAATGGGTCTTGGGCGATCACAGCGATTAATGAACAAA

AACCGAACTTTAAGATTGGGACCTTCATGATTCCAGGAAAAGAAAAAGGACAAAGCTTAACCGTTGGTGCGGGAGAC

TTGGCATGGTCTATCTCAGCCACCACCAAACATCCAAAAGAAGCCAATGCCTTTGTGGAATATATGACCCGTCCAGA

AGTCATGCAAAAATACTACGATGTGGACGGATCTCCAACAGCGATCGAAGGGGTCAAACAAGCAGGAGAAGATTCAC

CGCTTGCTGGTATGACCGAATATGCCTTTACGGATCGTCACTTGGTCTGGTTGCAACAATACTGGACCAGTGAAGCA

GACTTCCATACCTTGACCATGAACTATGTCTTGACCGGTGATAAACAAGGCATGGTCAATGATTTGAATGCCTTCTT

TAACCCGATGAAAGCGGATGTGGATTAG

MEWYKKIGLLATTGLALFGLGACSNYGKSADGTVTIEYFNQKKEMTKTLEEITRDFEKENPKIKVKVVNVPNAGEVL

KTRVLAGDVPDVVNIYPQSIELQEWAKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFE

ELGLKVPETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQPNAIKLSDPIMKD

DIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAITAINEQKPNFKIGTPMIPGKEKGQSLTVGAGD

LAWSISATTKHPKEANAFVEYMTRPEVMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEA

DFHTLTMNYVLTGDKQGMVNDLNAFFNPMKADVDZ

ID207-4123.1

ATGAAGAAAATCAAACCGCATGGACCGTTACCAAGTCAGACTCAGCTAGCTTATCTGGGAGATGAACTAGCAGCTTT

TATCCACTTCGGTCCTAATACCTTTTATGACCAAGAATGGGGGACTGGACAGGAGGATCCTGAGCGCTTTAACCCGA

GTCAGTTGGATGCGCGTGAGTGGGTTCGTGTGCTCAAGGAAACGGGCTTCAAAAAGTTGATTTTGGTGGTCAAGCAC

CACGATGGCTTTGTCCTTTATCCGACAGCTCACACAGATTATTCGGTTAAGGTCAGTCCTTGGAGGAGAGGAAAGGG

CGACTTGCTCCTTGAAGTATCCCAAGCTGCCACAGAGTTTGATATGGATATGGGGGTCTACCTGTCACCGTGGGATG

CCCATAGTCCCCTCTATCATGTGGACCGAGAAGCGGACTACAATGCCTATTATCTGGCTCAGTTGAAGGAAATCTTA

TCAAATCCTAACTATGGGAATGCTGGTAAGTTCGCTGAGGTTTGGATGGATGGTGCCAGAGGAGAGGGCGCGCAAAA

GGTTAATTATGAATTTGAAAAATGGTTTGAAACCATTCGTGACCTGCAGGGCGATTGCTTGATTTTTTCAACAGAAG

GCACCAGTATCCGCTGGATTGGCAATGAACGAGGGTATGCAGGTGATCCACTGTGGCAAAAGGTGAATCCTGATAAA

CTAGGAACAGAAGCAGAGCTGAACTATCTTCAGCACGGGGATCCCTCGGGCACGATTTTTTCAATCGGAGAGGCAGA

TGTTTCCATCCGTCCAGGCTGGTTCTACCATGAGGATCAGGATCCTAAGTCTCTCGAGGAGTTGGTCGAAATCTACT

TTCACTCAGTAGGGCGAGGAACTCCACTCTTGCTTAATATTCCGCCGAATCAAGCTGGGCTCTTTGATGCAAAGGAT

ATTGAACGACTTTATGAATTTGCGACCTATCGCAATGAGCTCTATAAAGAAGATTTGGCTCTGGGAGCTGAGGTATC

TGGTCCAGCTCTTTCCGCAGACTTTGCTTGTCGCCATTTGACAGACGGCCTTGAGACCAGCTCTTGGGCAAGCGATG

CAGACTTGCCCATCCAGTTAGAACTCGACTTAGGTTCTCCTAAAACTTTTGATGTAATTGAGTTAAGAGAAGATTTG

AAGCTAGGGCAACGAATCGCTGCTTTTCATGTGCAAGTAGAGGTGGATGGTGTCTGGCAGGAGTTTGGTTCGGGTCA

TACTGTTGGTTACAAACGTCTCTTACGAGGAGCAGTTGTTGAGGCACAGAAGATACGTGTAGTCATTACAGAATCAC

AGGCTTTGCCTTTGTTGACCAAGATTTCCCTTTATAAAACTCCTGGATTATCAAAAAAAGAAGTTGTTCAGGAACTA

GCATTTGCAGAAAAAAGCCTAGCTGTGGCAAAGGGAGAAAATGCCTATTTTACAGTTAAGCGCAGAGAATGTAGTGG

TCCTTTAGAAGCTAAGATTTCGATTCAACCGGGGACAGGTGTCCATGGTGTCGCCTATCAGGATGAGATTCAAGTCC

TTGCGTTTCAAACTGGTGAGACTGAAAAAAGTCTGACGCTACCAACCTTGTATTTCGCAGGAGATAAAACCTTGGAT

TTCTATCTGAACCTAACGGTGGATGGTCAGCTTGTGGATCAACTTCAAGTCCAAGTTTCATAA

MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQEDPERFNPSQLDAREWVRVLKETGFKKLILVVKH

HDGFVLYPTAHTDYSVKVSPWRRGKGDLLLEVSQAATEFDMDMGVYLSPWDAHSPLYHVDREADYNAYYLAQLKEIL

SNPNYGNAGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGDCLIFSTEGTSIRWIGNERGYAGDPLWQKVNPDK

LGTEAELNYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLEELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKD

IERLYEFATYRNELYKEDLALGAEVSGPALSADFACRHLTDGLETSSWASDADLPIQLELDLGSPKTFDVIELREDL

KLGQRIAAFHVQVEVDGVWQEFGSGHTVGYKRLLRGAVVEAQKIRVVITESQALPLLTKISLYKTPGLSKKEVVQEL

AFAEKSLAVAKGENAYFTVKRRECSGPLEAKISIQPGTGVHGVAYQDEIQVLAFQTGETEKSLTLPTLYFAGDKTLD

FYLNLTVDGQLVDQLQVQVSZ

TD208-4125.12

ATGCTTGAAAGACTGAAAAGAATACATTATATGTTTTGGATCAGTTTAATTTTTATGATTTTCCCCATCCTGTCTGT

AGTGACTGGGTGGCTTTCTGCCTGGCATTTATTGATTGATATTCTATTTGTAGTGGCATATTTGGGTGTTTTAACAA

CTAAGAGCCAGCGCCTATCTTGGCTATATTGGGGCCTCATGCTGACTTATGTAGTTGGGAATACTGCCTTTGTTGCT

GTTAATTATATCTGGTTTTTCTTTTTCCTATCCAATCTCTTAAGTTATCATTTCAGCGTACGTAGTTTAAAGTCTTT

ACATGTCTGGACTTTTCTTCTTGCTCAAGTCCTTGTTGTGGGGCAACTGTTGATTTTTCAGAGAATCGAAGTTGAGT

TTCTATTCTATCTACTTGTAATTCTTACTTTTGTCGATTTAATGACTTTTGGATTGGTTCGGATTCGTATTGTCGAG

GATTTGAAAGAAGCTCAGGTCAAGCAAAATGCTCAGATAAATCTATTGCTTGCTGAAAATGAACGTAGTCGTATCGG

TCAGGATTTGCATGATAGTCTGGGACATACCTTTGCTATGCTGAGTGTCAAGACAGATTTAGCCTTGCAGTTATTTC

AGATGGAGGCTTATCCACAGGTGGAAAAGGAATTAAAAGAAATTCACCAGATCAGCAAGGATCCATGA

MLERLKRIHYMFWISLIFMIFPILSVVTGWLSAWHLLIDILFVVAYLGVLTTKSQRLSWLYWGLMLTYVVGNTAFVA

VNYIWFFFFLSNLLSYHFSVRSLKSLHVWTFLLAQVLVVGQLLIFQRIEVEFLFYLLVILTFVDLMTFGLVRIRIVE

DLYEAQVKQNAQINLLLAENERSRIGQDLHDSLGHTFAMLSVKTDLALQLFQMEAYPQVEKELKEIHQISKDPZ

TD209-4126.3

ATGAATGATAAGTTAAAAATCTTCTTGTTGCTAGGAGTATTTTTTCTAGCCATAACCGGTTTCTATGTTCTATTGAT

ACGAAATGCAGGGCAGACAGATGCCTCGCAAATTGAAAAGGCGGCAGTTAGCCAAGGAGGAAAAGCAGTGAAAAAAA

CAGAAATTAGTAAAGACGCAGACTTGCACGAAATTTATCTAGCTGGAGGTTGTTTCTGGGGAGTGGAGGAATATTTC

TCACGTGTTCCCGGGGTGACGGATGCCGTTTCAGGCTATGCAAATGGTAGAGGAGAAACAACCAAGTACGAATTGAT

TAACCAAACAGGTCATGCAGAAACCGTCCATGTCACCTATGATGCCAAGCAAATTTCTCTCAAGGAAATCCTGCTTC

ACTATTTCCGCATTATCAATCCAACCAGCAAAAATAAACAAGGAAATGATGTGGGGACCCAGTACCGTACTGGTGTT

TATTACACAGATGACAAGGATTTGGAAGTGATTAACCAAGTCTTTGATGAGGTGGCTAAGAAATACGATCAACCTCT

AGCAGTTGAAAAGGAAAACTTGAAGAATTTTGTGGTGGCTGAGGATTACCATCAAGACTATCTCAAGAAAAATCCAA

ATGGCTACTGCCATATCAATGTTAATCAGGCGGCCTATCCTGTCATTGATGCCAGCAAATATCCAAAACCAAGTGAT

GAGGAATTGAAAAAGACCCTGTCACCTGAGGAGTATGCAGTTACCCAGGAAAAT?AAACAGAACGAGCTTTCTCAAA

CCGTTACTGGGATAAATTTGAATCCGGTATCTATGTGGATATAGCAACTGGGGAACCTCTCTTTTCATCAAAAGACA

AATTTGAGTCTGGTTGTGGCTGGCCTAGTTTTACCCAACCCATCAGTCCAGATGTTGTCACCTACAAGGAAGATAAG

TCCTACAATATGACGCGTATGGAAGTGCGGAGCCGAGTAGGAGATTCTCACCTTGGGCATGTCTTTACGGATGGTCC

ACAGGACAAGGGCGGCTTACGTTACTGTATCAATAGCCTCTCTATCCGCTTTATTCCCAAAGACCAAATGGAAGAAA

AAGgcTACGCTTATTTACTAGATTATGTTGATTAA

MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADLHEIYLAGGCFWGVEEYF

SRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGV

YYTDDKDLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSD

EELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPDVVTYKEDK

SYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVDZ

ID210-4127.1

ATGAAAAAGAAATGGATGTATTATGCTGCTTGTTCTTCTAATGAATCTGCCGATGACAGTTCATCTGATAAAGGAGA

CGGCGGTTCGCTAGTCGTTTATTCACCAAACTCAGAGGGCTTAATTGGAGCAACTATTCCTGCCTTTGAAGAAAAAT

ATGGTATCAAAGTAGAACTGATTCAAGCTGGTACTGGAGAACTTTTCAAAAAACTAGAGTCAGAAAAAGAAGTTCCT

GTAGCTGATGTTATCTTTGGTGGTTCTTATACACAATATACTACCCACGGAGAACTCTTTGAAAACTATACTTCAAA

AGAAAATGATAATGTTATCAAAGAATATCAAAACACAACTGGCTACTCTACTCCTTATACACTAGATGGTAGTGTTT

TAATCGTCAACCCTGATTTAACTAAAGGCATGAACATCGAAGGATATAACGATCTTTTCAAACCTGAACTAAAAGGA

AAAATCGCAACTGCTGACCCAGCAAACTCTTCTAGCGCCTTTGCTCAATTAACAAATATGCTACAAGCTCAAGGTGG

TTACAAAGATGATAAGGCTTGGTCTTATGTAAAAGATCTTTTCACACTTATTGATGGTAAAATCGGTTCAAGTTCAT

CTAGTGTCTATAAAGTAGTCGCTGATGGAGAAATGGCTGTTGGTCTCTCTTATGAAGATCCAGCAGTTAAACTCTTA

AATGACGGAGCTAACATTAAGGTAGTCTATCCAAAAGAAGGAACCGTCTTCCTACCTGCTAGTGCTGCTATCGTTAA

AAAATCTAAAAATATGGAAAATGCCAAGAAATTTATCGATTTATTATCTCTCAAGAAGTACAAGATACACTTGGGTA

CAACCACTACTAACCGTCCTGTTCGTAAAAATGCTAAAACAAGCGAAAACATGAAACCAATTGACAAAATCAAAACA

CTCACTGAAGATTATGATTATGTCATCAAGAATAAATCAGATATCGTTAAGAAATACAACGAAGTCTTTACAGATAT

CCAATCTAAACAGTAA

MKKKWMYYAACSSNESADDSSSDKGDGGSLVVYSPNSEGLIGATIPAFEEKYGIKVELIQAGTGELFKKLESEKEVP

VADVIFGGSYTQYTTHGELFENYTSKENDNVIKEYQNTTGYSTPYTLDGSVLIVNPDLTKGMNIEGYNDLFKPELKG

KIATADPANSSSAFAQLTNMLQAQGGYKDDKAWSYVKDLFTLIDGKIGSSSSSVYKVVADGEMAVGLSYEDPAVKLL

NDGANIKVVYPKEGTVFLPASAAIVKKSKNMENAKKFIDFIISQEVQDTLGTTTTNRPVRKNAKTSENMKPIDKIKT

LTEDYDYVIKNKSDIVKKYNEVFTDIQSKQZ

ID211-4127.2

ATGAGTGAGATCAAAATTATTAACGCCAAAAAAATCTACCACGATGTCCCTGTTATTGAGAATTTGAACATTACAAT

TCCAAAAGGAAGTCTCTTTACCCTTCTTGGAGCTTCAGGATGTGGGAAAACGACCCTTCTTCGTATGATTGCAGGTT

TCAACAGTATCGAAGGTGGAGAATTTTACTTCGATGATACAAAAATCAATAATATGGAACCCAGCAAACGCAATATC

GGGATGGTTTTCCAAAACTACGCTATTTTCCCACATTTGACTGTCCGAGACAACGTTGCTTTTGGTCTTATGCAAAA

GAAGGTTCCAAAAGAAGAATTGATTCAACAGACCAACAAGTATCTTGAACTCATGCAAATTGCTCAATATGCGGATC

GAAAGCCCGATAAACTCAGTGGTGGACAACAACAACGTGTCACCTTGGCATGCGCCTTAGCGGTTAATCCAAGTGTT

CTCCTCATGGACGAGCCACTTAGTAATCTGGAGGCCAAACTTCGCTTGGATATGCGTCAAGCCATCCGAGAAATCCA

ACACGAAGTGGGAATTACAACTGTTTATGTAACCCACGACCAAGAAGAAGCCATGGCTATTTCAGACCAAATTGCTG

TTATGAAAGATGGGGTGATCCAACAAATCGGCCGACCAAAAGAACTCTATCATAAACCAGCTAATGAGTTTGTGGCG

ACCTTTATCGGACGCACAAATATTATCCCTGCCAATCTTGAAAAACGGAGCGACGGCGCTTATATCGTCTTTTCAGA

TGGCTATGCCCTTCGAATGCCAGCTCTTGATCAGGTTGAGGAGCAAGCTATTCATGTAAGCATTCGTCCCGAAGAGT

TTATCAAAGATGAATCTGGAGATATTGAAGGAACTATTAGAGATAGCGTCTATCTTGGACTAAATACGGATTATTTC

ATTGAGACAGGTITTGCCTCAAAAATTCAAGTTAGTGAAGAATCAACTTTTGAAGAAGATCTACAAAAAGGCAATCG

TATTCGTCTACGAATCAATACGCAAAAATTAAACATCTTTTCTGCAGATGGTTCCCAAAACCTGATAAAAGGAGTCA

ACCATGGAACGTAA

MSEIKITNAKKIYHDVPVIENLNITIPKGSLFTLLGASGCGKTTLLRMIAGFNSIEGGEFYFDDTKINNMEPSKRNI

GMVFQNYAIFPHLTVRDNVAFGLMQKKVPKEELIQQTNKYLELMQIAQYADRKPDKLSGGQQQRVTLACALAVNPSV

LLMDEPLSNLEAKLRLDMRQAIREIQHEVGITTVYVTHDQEEAMAISDQIAVMKDGVIQQIGRPKELYHKPANEFVA

TFIGRTNIIPANLEKRSDGAYIVFSDGYALRMPALDQVEEQAIHVSIRPEEFIKDESGDIEGTIRDSVYLGLNTDYF

IETGFASKIQVSEESTFEEDLQKGNRIRLRINTQKLNIFSADGSQNLIKGVNHGTZ

ID212-4136.1

ATGAAGAAAAAATTATTGGCAGGTGCCATCACACTATTATCAGTAGCAACTTTAGCAGCTTGTTCGAAAGGGTCAGA

AGGTGCAGACCTTATCAGCATGAAAGGGGATGTCATTACAGAACATCAATTTTATGAGCAAGTGAAAAGCAACCCTT

CAGCCCAACAAGTCTTGTTAAATATGACCATCCAAAAAGTTTTTGAAAAACAATATGGCTCAGAGCTTGATGATAAA

GAGGTTGATGATACTATTGCCGAAGAAAAAAAACAATATGGCGAAAACTACCAACGTGTCTTGTCACAAGCAGGTAT

GACTCTTGAAACACGTAAAGCTCAAATTCGTACAAGTAAATTAGTTGAGTTGGCAGTTAAGAAGGTAGCAGAAGCTG

AATTGACAGAAGTGAAGCCTATAAGAGCCTTTGATGAGTACACTCCAGATGTAACGGCTCAAATCATCCGTCTTAAT

AATGAAGATAAGGCCAAAGAAGTTCTCGAAAAAGCCAAGGCAGAAGGTGCTGATTTTGCTCAATTAGCCAAAGATAA

TTCAACTGATGAAAAAACAAAAGAAAATGGTGGAGAAATTACCTTTGATTCTGCTTCAACAGAAGTACCTGAGCAAG

TCAAAAAAGCCGCTTTCGCTTTAGATGTGGATGGTGTTTCTGATGTGATTACAGCAACTGGCACACAAGCCTACAGT

AGCCAATATTACATTGTAAAACTCACTAAGAAAACAGAAAAATCATCTAATATTGATGACTACAAAGAAAAATTAAA

AACTGTTATCTTGACTCAAAAACAAAATGATTCAACATTTGTTCAAAGCATTATCGGAAAAGAATTGCAAGCAGCCA

ATATCAAGGTTAAGGACCAAGCCTTCCAAAATATCTTTACCCAATATATCGGTGGTGGAGATTCAAGCTCAAGCAGT

AGTACATCAAACGAATAG

MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKSNPSAQQVLLNMTIQKVFEKQYGSELDDK

EVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLN

NEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYS

SQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSS

STSNEZ

ID213-4137.3

ATGAAAAAAAATATTAAACAATATGTAACCTTAGGTACTGTAGTGGTATTATCAGCATTTGTTGCTAACTCAGTTGC

AGCTCAGGAGACTGAAACTTCTGAAGTATCAACACCAAAGTTGGTGCAACCTGTTGCACCAACGACTCCGATTTCGG

AAGTACAACCTACATCGGATAACTCTTCGGAAGTTACTGTACAACCTCGAACAGTTGAAACTACTGTTAAGGATCCA

TCTTCTACAGCGGAAGAAACTCCTGTCTTAGAAAAAAATAATGTTACTTTAACAGGGGGCGGAGAAAATGTTACTAA

AGAGTTAAAGGATAAATTTACTAGCGGTGACTTTACTGTAGTGATTAAGTACAATCAGTCAAGTGAGAAAGGCTTAC

AAGCTCTGTTTGGAATATCTAATTCCAAACCCGGTCAACAAAATAGTTATGTAGATGTGTTCCTTAGAGACAATGGT

GAGTTGGGGATGGAAGCGCGTGATACTTCTTCCAATAAAAATAACCTAGTATCCAGACCTGCTTCAGTTTGGGGTAA

GTACAAACAAGAGGCTGTGACTAACACTGTTGCAGTAGTAGCAGATTCAGTCAAAAAAACATATTCTTTATACGCAA

ATGGTACAAAAGTAGTAGAAAAGAAAGTGGATAATTTCCTAAACATCAAGGATATTAAAGGTATTGATTACTATATG

CTTGGGGGAGTGAAACGTGCAGGAAAAACGGCGTTTGGTTTTAACGGAACACTAGAAAATATCAAATTCTTTAATAG

TGCATTGGATGAAGAAACTGTTAAAAAGATGACAA?AAACGCTGTTACTGGACATTTAATTTATACGGCTAATGATA

CAACAGGTTCTAACTATTTCCGTATTCCAGTTCTGTATACTTTTAGCAATGGTCGGGTATTTTCAAGCATTGACGCT

CGTTACGGTGGAACTCATGATTTCTTGAATAAAATTAATATTGCTACAAGTTATAGTGATGATAATGGTAAGACATG

GACTAAAC?AAAATTAACATTGGCATTCGATGATTTTGCGCCAGTACCATTAGAATGGCCTCGTGAAGTTGGTGGAC

GTGACTTACAAATCAGCGGTGGTGCAACCTATATTGACTCTGTTATTGTTGAAAAAAAGAACAAACAAGTACTCATG

TTTGCTGATGTGATGCCTGCTGGAGTAAGTTTTAGAGAAGCAACTAGAAAAGATTCAGGTTATAAACAAATTGATGG

TAATTATTACCTTAAATTAAGGAAACAAGGTGATACTGATTACAATTATACTATTCGTGAGAATGGTACTGTATACG

ACGATCGTACCAACAGACCAACTGAATTTTCAGTAGATAAAAATTTCGGTATTAAACAAAATGGTAATTATTTGACG

GTAGAGCGG

MKKNIKQYVTLGTVVVLSAFVANSVAAQETETSEVSTPKLVQPVAPTTPISEVQPTSDNSSEVTVQPRTVETTVKDP

SSTAEETPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNG

ELGMEARDTSSNKNNLVSRPASVWGKYKQEAYTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYM

LGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDA

RYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIYEKKNKQVLM

FADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLT

VER

ID214-4185

ATGAAAAAATTTAGCCTATTACTAGCTATCCTACCATTTTTGGTTGCCTGTGAGAATCAAGCTACACCCAAAGAGAC

TAGCGCTCAAAAGACAATCGTCCTTGCTACAGCTGGCGACGTGCCACCATTTGACTACGAAGACAAGGGCAATCTGA

CAGGCTTTGATATCGAAGTTTTAAAGGCAGTAGATGAAAAACTCAGCGACTACGAGATTCAATTCCAAAGAACCGCC

TGGGAGAGCATCTTCCCAGGACTTGATTCTGGTCACTATCAGGCTGCGGCCAATAACTTGAGTTACACAAAAGAGCG

TGCTGAAAAATACCTTTACTCGCTTCCAATTTCCAACAATCCCCTCGTCCTTGTCAGCAACAAGAAAAATCCTTTGA

CTTCTCTTGACCAGATCGCTGGTAAAACAACACAAGAGGATACCGGAACTTCTAACGCTCAATTCATCAATAACTGG

AATCAGAAACACACTGATAATCCCGCTACAATTAATTTTTCTGGTGAGGATATTGGTAAACGAATCCTAGACCTTGC

TAACGGAGAGTTTGATTTCCTAGTTTTTGACAAGGTATCCGTTCAAAAGATTATCAAGGACCGTGGTTTAGACCTCT

CAGTCGTTGATTTACCTTCTGCAGATAGCCCCAGCAATTATATCATTTTCTCAAGCGACCAAAAAGAGTTTAAAGAG

CAATTTGATAAAGCGCTCAAAGAACTCTATCAAGACGGAACCCTTGAAAAACTCAGCAATACCTATCTAGGTGGTTC

TTACCTCCCAGATCAATCTCAGTTACAATAA

MKKFSLLLAILPFLVACENQATPKETSAQKTIVLATAGDVPPFDYEDKGNLTGFDIEVLKAVDEKLSDYEIQFQRTA

WESIFPGLDSGHYQAAANNLSYTKERAEKYLYSLPISNNPLVLVSNKKNPLTSLDQIAGKTTQEDTGTSNAQFINNW

NQKHTDNPATINFSGEDIGKRILDLANGEFDFLVFDKVSVQKIIKDRGLDLSVVDLPSADSPSNYIIFSSDQKEFKE

QFDKALKELYQDGTLEKLSNTYLGGSYLPDQSQLQZ

TD215-4211.1

ATGAAAAAAAATAGTTTATATATCATATCCTCACTCTTTTTTGCTTGTGTCTTATTTGTCTATGCTACGGCGACGAA

TTTTCAAAACAGTACCAGTGCTAGGCAGGTAAAAACGGAAACCTATACTAATACAGTAACAAATGTCCCTATTGACA

TACGCTATAATAGTGATAAGTATTTTATTAGCGGTTTTGCTTCAGAAGTATCAGTGGTCTTGACTGGTGCAAATCGC

CTATCGCTAGCTAGTAAATGCAAGAAAGTACACGTAAATTCAAGGT?TACTGCTGACCTAACAGATGCCGGTGTTGG

AACGATTGAAGTTCCTTTGAGCATTGAAGATTTACCCAATGGGCTGACCGCTGTGGCGACTCCGCAAAAAATTACAG

TCAAGATTGGTAAGAAGGCTCAGAAGGATAAGGTAAAGATTGTACCAGAGATTGACCCTAGTCAAATTGATAGTCGG

GTACAAATTGAAAATGTCATGGTGTCAGATAAAGAAGTGTCTATTACGAGTGACCAAGAGACATTGGATAGAATTGA

TAAGATTATCGCTGTTTTGCCAACTAGCGAACGTATAACAGGTAATTACAGTGGTTCAGTACCTTTGCAGGCAATCG

ACCGCAATGGTGTTGTCTTACCGGCAGTTATCACTCCGTTTGATACAATAATGAAGGTGACTACAAAACCAGTAGCA

CCAAGTTCAAGCACATCAAATTCAAGTACAAGCAGTTCATCGGAGACATCTTCGTCAACGAAAGCAACTAGTTCAAA

AACGAATTAA

MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNTVTNVPIDIRYNSDKYFISGFASEVSVVLTGANR

LSLASEMQESTRKFKVTADLTDAGVGTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSR

VQIENVMVSDKEVSITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITPFDTIMKVTTKPVA

PSSSTSNSSTSSSSETSSSTKATSSKTNZ

ID216-4127.3

ATGTTGATTGGCGAAGGGTATCGGACTTTCCCTGTCCTGATTTATACCCAATTTATTAGCGAGGTTGGAGGAAATTC

TGCTTTTGCAATTATGGCGATTATCATTGCCTTGGCAATTTTCCTTATCCAAAAACACATTGCAAACCGCTACAGTT

TCAGCATGAATCTGCTCCATCCAATTGAGCCTAAAAAAACTACAAAAGGAAAAATGGCTGCCATTTATGCAACAGTC

TACGGAATTATCTTTATCTCTGTTTTACCTCAAATCTACTTAATTTATACCTCTTTCCTAAAAACATCAGGTATGGT

ATCTGTTAAAGGTTATTCTCCAAACAGTTACAAGGTAGCTTTCCATCGTATGGGATCTGCTATTTTCAATACCATTC

GTATCCCTTTGATTGCCTTAGTTCTAGTTGTTCTATTTGCGACATTTATCTCCTACCTAGCCGTTAGAAAACGGAAT

TTGTTTACAAACTTAATTGACAGCCTCAGTATGGTACCTTATATTGTACCAGGAACCGTTCTAGGGATTGCCTTCAT

TTCTTCCTTCAATACTGGTCTATTTGGAAGTGGATTTCTTATGATTACAGGGACTGCTTTCATCTTGATTATGTCTC

TATCTGCCAGAAGATTACCTTATACTATTCGCTCATCTGTTGCTAGCTTACAACAAATAGCACCAAGTATTGAAGAA

GCTGCTGAAAGCTTAGGAAGTAGTCGTCTCAATACCTTTGCTAAGATTACAACTCCAATGATGCTATCTGGTATCAT

TTCTGGAGCCATCTTATCTTGA

MLIGEGYRTFPVLIYTQFISEVGGNSAFAIMAIIIALAIFLIQKHIANRYSFSMNLLHPIEPKKTTKGKMAAIYATV

YGIIFISVLPQIYLIYTSFLKTSGMVSVKGYSPNSYKVAFHRMGSAIFNTIRIPLIALVLVVLFATFISYIAVRKRN

LFTNLIDSLSMVPYIVPGTVLGIAFISSFNTGLFGSGFLMITGTAFILIMSLSARRLPYTIRSSVASLQQIAPSIEE

AAESLGSSRLNTFAKITTPMMLSGIISGAILSZ

Table 4

ID301

ATGAATAAGAAAAAAATGATTTTAACAAGTCTAGCCAGCGTCGCTATCTTAGGGGCTGGTTTTGTTACGTCTCAGCC

TACTTTTGTAAGAGCAGAAGAATCTCCACAAGTTGTCG?AAAATCTTCATTAGAGAAGAAATATGAGGAAGCAAAAG

CAAAAGCTGATACTGCCAAGAAAGATTACGAAACGGCTAAAAAGAAAGCAGAAGACGCTCAGAAAAAGTATGAAGAT

GATCAGAAGAGAACTGAGGAGAAAGCTCGAAAAGAAGCAGAAGCATCTCAAAAATTGAATGATGTGGCGCTTGTTGT

TCAAAATGCATATAAAGAGTACCGAGAAGTTCAAAATCAACGTAGTAAATATAAATCTGACGCTGAATATCAGAAAA

AATTAACAGAGGTCGACTCTAAAATAGAGAAGGCTAGGAAAGAGCAACAGGACTTGCAAAATAAATTTAATGAAGTA

AGAGCAGTTGTAGTTCCTGAACCAAATGCGTTGGCTGAGACTAAGAAAAAAGCAGAAGAAGCTAAAGCAGAAGAAAA

AGTAGCTAAGAGAAAATATGATTATGCAACTCTAAAGGTAGCACTAGCGAAGAAAGAAGTAGAGGCTAAGGAACTTG

AAATTGAAAAACTTCAATATGAAATTTCTACTTTGGAACAAGAAGTTGCTACTGCTCAACATCAAGTAGATAATTTG

AAAAAACTTCTTGCTGGTGCGGATCCTGATGATGGCACAGAAGTTATAGAAGCTAAATTAAAAAAAGGAGAAGCTGA

GCTAAACGCTAAACAAGCTGAGTTAGCAAAAAAACAAACAGAACTTGAAAAACTTCTTGACAGCCTTGATCCTGAAG

GTAAGACTCAGGATGAATTAGATAAAGAAGCAGAAGAAGCTGAGTTGGATAAAAAAGCTGATGAACTTCAAAATAAA

GTTGCTGATTTAGAAAAAGAAATTAGTAACCTTGAAATATTACTTGGAGGGGCTGATCCTGAAGATGATACTGCTGC

TCTTCAAAATAAATTAGCTGCTAAAAAAGCTGAGTTAGCAAAAAAACAAACAGAACTTGAAAAACTTCTTGACAGCC

TTGATCCTGAAGGTAAGACTCAGGATGAATTAGATAAAGAAGCAGAAGAAGCTGAGTTGGATAAAAAAGCTGATGAA

CTTCAAAATAAAGTTGCTGATTTAGAAAAAGAAATTAGTAACCTTGAAATATTACTTGGAGGGGCTGATTCTGAAGA

TGATACTGCTGCTCTTCAAAATAAATTAGCTACTAAAAAAGCTGAATTGGAAAAAACTCAAAAAGAATTAGATGCAG

CTCTTAATGAGTTAGGCCCTGATGGAGATGAAGAAGAAACTCCAGCGCCGGCTCCTCAACCAGAGCAACCAGCTCCT

GCACCAAAACCAGAGCAACCAGCTCCAGCTCCAAAACCAGAGCAACCAGCTCCTGCACCAAAACCAGAGCAACCAGC

TCCAGCTCCAAAACCAGAGCAACCAGCTCCAGCTCCAAAACCAGAGCAACCAGCTAAGCCGGAGAAACCAGCTGAAG

AGCCTACTCAACCAGAAAAACCAGCCACTCCAAAAACAGGCTGGAAACAAGAAAACGGTATGTGGTATTTCTACAAT

ACTGATGGTTCAATGGCAATAGGTTGGCTCCAAAACAACGGTTCATGGTACTACCTAAACGCTAACGGCGCTATGGC

AACAGGTTGGGTGAAAGATGGAGATACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCA

AAGTATCAGATAAATGGTACTATGTCAACAGCAATGGCGCTATGGCGACAGGCTGGCTCCAATACAATGGCTCATGG

TACTACCTCAACGCTAATGGTGATATGGCGACAGGATGGCTCCAATACAACGGTTCATGGTATTACCTCAACGCTAA

TGGTGATATGGCGACAGGATGGGCTAAAGTCAACGGTTCATGGTACTACCTAAACGCTAACGGTGCTATGGCTACAG

GTTGGGCTAAAGTCAACGGTTCATGGTACTACCTAAACGCTAACGGTTCAATGGCAACAGGTTGGGTGAAAGATGGA

GATACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTA

TGTCAATGGCTTAGGTGCCCTTGCAGTCAACACAACTGTAGATGGCTATAAAGTCAATGCCAATGGTGAATGGGTTT

AA

MNKKKMILTSLASVAILGAGFVTSQPTFVRAEESPQVVEKSSLEKKYEEAKAKADTAKKDYETAKKKAEDAQKKYED

DQKRTEEKARKEAEASQKLNDVALVVQNAYKEYREVQNQRSKYKSDAEYQKKLTEVDSKIEKARKEQQDLQNKFNEV

RAVVVPEPNALAETKKKAEEAKAEEKVAKRKYDYATLKVALAKKEVEAKELEIEKLQYEISTLEQEVATAQHQVDNL

KKLLAGADPDDGTEVIEAKLKKGEAELNAKQAELAKKQTELEKLLDSLDPEGKTQDELDKEAEEAELDKKADELQNK

VADLEKEISNLEILLGGADPEDDTAALQNKLAAKKAELAKKQTELEKLLDSLDPEGKTQDELDKEAEEAELDKKADE

LQNKVADLEKEISNLEILLGGADSEDDTAALQNKLATKKAELEKTQKELDAALNELGPDGDEEETPAPAPQPEQPAP

APKPEQPAPAPKPEQPAPAPKPEQPAPAPKPEQPAPAPKPEQPAKPEKPAEEPTQPEKPATPKTGWKQENGMWYFYN

TDGSMAIGWLQNNGSWYYLNANGAMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNSNGAMATGWLQYNGSW

YYLNANGDMATGWLQYNGSWYYLNANGDMATGWAKVNGSWYYLNANGAMATGWAKVNGSWYYLNANGSMATGWVKDG

DTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWVZ

ID302

ATGTTTGCATCAAAAAGCGAAAGAAAAGTACATTATTCAATTCGTAAATTTAGTGTTGGAGTAGCTAGTGTAGTTGT

TGCCAGTCTTGTTATGGGAAGTGTGGTTCATGCGACAGAGAACGAGGGAGCTACCCAAGTACCCACTTCTTCTAATA

GGGCAAATGAAAGTCAGGCAGAACAAGGAGAACAACCTAAAAAACTCGATTCAGAACGAGATAAGGCAAGGAAAGAG

GTCGAGGAATATGTAAAAAAAATAGTGGGTGAGAGCTATGCAAAATCAACTAAAAAGCGACATACAATTACTGTAGC

TCTAGTTAACGAGTTGAACAACATTAAGAACGAGTATTTGAATAAAATAGTTGAATCAACCTCAGAAAGCCAACTAC

AGATACTGATGATGGAGAGTCGATCAAAAGTAGATGAAGCTGTGTCTAAGTTTGAAAAGGACTCATCTTCTTCGTCA

AGTTCAGACTCTTCCACTAAACCGGAAGCTTCAGATACAGCGAAGCCAAACAAGCCGACAGAACCAGGAGAAAAGGT

AGCAGAAGCTAAGAAGAAGGTTGAAGAAGCTGAGAAAAAAGCCAAGGATCAAAAAGAAGAAGATCGTCGTAACTACC

CAACCATTACTTACAAAACGCTTGAACTTGAAATTGCTGAGTCCGATGTGGAAGTTAAAAAAGCGGAGCTTGAACTA

GTAAAAGTGAAAGCTAACGAACCTCGAGACGAGCAAAAAATTAAGCAAGCAGAAGCGGAAGTTGAGAGTAAACAAGC

TGAGGCTACAAGGTTAAAAAAAATCAAGACAGATCGTGAAGAAGCAGAAGAAGAAGCTAAACGAAGAGCAGATGCTA

AAGAGCAAGGTAAACCAAAGGGGCGGGCAAAACGAGGAGTTCCTGGAGAGCTAGCAACACCTGATAAAAAAGAAAAT

GATGCGAAGTCTTCAGATTCTAGCGTAGGTGAAGAAACTCTTCCAAGCCCATCCCTGAAACCAGAAAAAAAGGTAGC

AGAAGCTGAGAAGAAGGTTGAAGAAGCTAAGAAAAAAGCCGAGGATCAAAAAGAAGAAGATCGCCGTAACTACCCAA

CCAATACTTACAAAACGCTTGAACTTGAAATTGCTGAGTCCGATGTGGAAGTTAAAAAAGCGGAGCTTGAACTAGTA

AAAGAGGAAGCTAAGGAACCTCGAAACGAGGAAAAAGTTAAGCAAGCAAAAGCGGAAGTTGAGAGTAAAAAAGCTGA

GGCTACAAGGTTAGAAAAAATCAAGACAGATCGTAAAAAAGCAGAAGAAGAAGCTAAACGAAAAGCAGCAGAAGAAG

ATAAAGTTAAAGAAAAACCAGCTGAACAACCACAACCAGCGCCGGCTCCAAAAGCAGAAAAACCAGCTCCAGCTCCA

AAACCAGAGAATCCAGCTGAACAACCAAAAGCAGAAAAACCAGCTGATCAACAAGCTGAAGAAGACTATGCTCGTAG

ATCAGAAGAAGAATATAATCGCTTGACTCAACAGCAACCGCCAAAAACTGAAAAACCAGCACAACCATCTACTCCAA

AAACAGGCTGGAAACAAGAAAACGGTATGTGGTACTTCTACAATACTGATGGTTCAATGGCGACAGGATGGCTCCAA

AACAATGGCTCATGGTACTACCTCAACAGCAATGGCGCTATGGCGACAGGATGGCTCCAAAACAATGGTTCATGGTA

CTATCTAAACGCTAATGGTTCAATGGCAACAGGATGGCTCCAAAACAATGGTTCATGGTACTACCTAAACGCTAATG

GTTCAATGGCGACAGGATGGCTCCAATACAATGGCTCATGGTACTACCTAAACGCTAATGGTTCAATGGCGACAGGA

TGGCTCCAATACAATGGCTCATGGTACTACCTAAACGCTAATGGTGATATGGCGACAGGTTGGGTGAAAGATGGAGA

TACCTGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTATG

TCAATGGCTCAGGTGCCCTTGCAGTCAACACAACTGTAGATGGCTATGGAGTCAATGCCAATGGTGAATGGGTAAAC

TAA

MFASKSERKVHYSIRKFSVGVASVVVASLVMGSVVHATENEGATQVPTSSNRANESQAEQGEQPKKLDSERDKARKE

VEEYVKKIVGESYAKSTKKRHTITVALVNELNNIKNEYLNKIVESTSESQLQILMMESRSKVDEAVSKFEKDSSSSS

SSDSSTKPEASDTAKPNKPTEPGEKVAEAKKKVEEAEKKAKDQKEEDRRNYPTITYKTLELEIAESDVEVKKAELEL

VKVKANEPRDEQKIKQAEAEVESKQAEATRLKKIKTDREEAEEEAKRRADAKEQGKPKGRAKRGVPGELATPDKKEN

DAKSSDSSVGEETLPSPSLKPEKKVAEAEKKVEEAKKKAEDQKEEDRRNYPTNTYKTLELEIAESDVEVKKAELELV

KEEAKEPRNEEKVKQAKAEVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPKAEKPAPAP

KPENPAEQPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKTGWKQENGMWYFYNTDGSMATGWLQ

NNGSWYYLNSNGAMATGWLQNNGSWYYLNANGSMATGWLQNNGSWYYLNANGSMATGWLQYNGSWYYLNANGSMATG

WLQYNGSWYYLNANGDMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGVNANGEWVN

Z

ID303

ATGGTAAAAAGACGTATAAGGAGAGGGACGAGAGAACCTGAAAAAGTTGTTGTTCCTGAGCAATCATCTATTCCTTC

GTATCCTGTATCTGTTACATCTAACCAAGGAACAGATGTAGCAGTAGAACCAGCTAAAGCAGTTGCTCCAACAACAG

ACTGGAAACAAGAAAATGGTATGTGGTATTTTTATAATACTGATGGTTCCATGGCAACAGGTTGGGTACAAGTTAAT

AGTTCATGGTACTACCTCAACAGCAACGGTTCTATGAAAGTCAATCAATGGTTCCAAGTTGGTGGTAAATGGTATTA

TGTAAATACATCGGGTGAGTTAGCGGTCAATACAAGTATAGATGGCTATAGAGTCAATGATAATGGTGAATGGGTGC

GTTAA

MVKRRIRRGTREPEKVVVPEQSSIPSYPVSVTSNQGTDVAVEPAKAVAPTTDWKQENGMWYFYNTDGSMATGWVQVN

SSWYYLNSNGSMKVNQWFQVGGKWYYVNTSGELAVNTSIDGYRVNDNGEWVRZ

ID304

CTGAATACAAGTTTTGTTCATGCTGCTGATGGGATTCAATATGTCAGAGATGATACTAGAGATAAAGAAGAGGGAAT

AGAGTATGATGACGCTGACAATGGGGATATTATTGTAAAAGTAGCGACTAAACCTAAGGTAGTAACCAAGAAAATTT

CAAGTACGCGAATTCGTTATGAAAAAGATGAAACAAAAGACCGTAGTGAAAATCCTGTTACAATTGATGGAGAGGAT

GGCTATGTAACTACGACAAGGACCTACGATGTTAATCCAGAGACTGGTTATGTTACCGAACAGGTTACTGTTGATAG

AAAAGAAGCCACGGATACAGTTATCAAAGTTCCAGCTAAAAGCAAGGTTGAAGAAGTTCTTGTTCCATTTGCTACTA

AATATGAAGCAGACAATGACCTTTCTGCAGGACAGGAGCAAGAGATTACTCTAGGAAAGAATGGGAAAACAGTTACA

ACGATAACTTATAATGTAGATGGAAAGAGTGGACAAGTAACTGAGAGTACTTTAAGTCAAAAAAAAGACTCTCAAAC

AAGAGTTGTTAAAAAAAGAACCAAGCCCCAAGTTCTTGTCCAAGAAATTCCAATCGAAACAGAATATCTCGATGGCC

CAACTCTTGATAAAAGTCAAGAAGTAGAAGAAGTAGGAGAAATTGGTAAATTACTCTTACTACAATCTATACTGTAG

LNTSFVHAADGIQYVRDDTRDKEEGIEYDDADNGDIIVKVATKPKVVTKKISSTRIRYEKDETKDRSENPVTIDGED

GYVTTTRTYDVNPETGYVTEQVTVDRKEATDTVIKVPAKSKVEEVLVPFATKYEADNDLSAGQEQEITLGKNGKTVT

TITYNVDGKSGQVTESTLSQKKDSQTRVVKKRTKPQVLVQEIPIETEYLDGPTLDKSQEVEEVGEIGKLLLLQSILZ

ID305

ATGAAGCTTTTGAAAAAAATGATGCAAATCGCACTAGCCACATTTTTCTTCGGTTTGTTAGCGACAAATACAGTATT

TGCAGATGATTCTGAAGGATGGCAGTTTGTCCAAGAAAATGGTAGAACCTACTACAAAAAGGGGGATCTAAAAGAAA

CCTACTGGAGAGTGATAGATGGGAAGTACTATTATTTTGATCCTTTATCCGGAGAGATGGTTGTCGGCTGGCAATAT

ATACCIGCTCCACACAAGGGGGTTACGATTGGTCCTTCTCCAAGAATAGAGATTGCTGTTAGACCAGATTGGTTTTA

TTTTGGTCAAGATGGTGTATTACAAGAATTTGTTGGCAAGCAAGTTTTAGAAGCAAAAACTGCTACGAATACCAACA

AACATCATGGGGAAGAATATGATAGCCAAGCAGAGAAACGAGTCTATTATTTTGAAGATCAGCGTAGTTATCATACT

TTAAAAACTGGTTGGATTTATGAAGAGGGTCATTGGTATTATTTACAGAAGGATGGTGGCTTTGATTCGCGCATCAA

CAGATTGACGGTTGGAGAGCTAGCACGTGGTTGGGTTAAGGATTACCCTCTTACGTATGATGAAGAGAAGCTAAAAG

CAGCTCCATGGTACTATCTAAATCCAGCAACTGGCATTATGCAAACAGGTTGGCAATATCTAGGTAATAGATGGTAC

TACCTCCATTCGTCAGGAGCTATGGCAACTGGCTGGTATAAGGAAGGCTCAACTTGGTACTATCTAGATGCTGAAAA

TGGTGATATGAGAACTGGCTGGCAAAACCTTGGGAACAAATGGTACTATCTCCGTTCATCAGGAGCTATGGCAACTG

GTTGGTATCAGGAAAGTTCGACTTGGTACTATCTAAATGCAAGTAATGGAGATATGAAAACAGGCTGGTTCCAAGTC

AATGGTAACTGGTACTATGCCTATGATTCAGGTGCTTTAGCTGTTAATACCACAGTAGGTGGTTACTACTTAAACTA

TAATGGTGAATGGGTTAAGTAA

MKLLKKMMQIALATFFFGLLATNTVFADDSEGWQFVQENGRTYYKKGDLKETYWRVIDGKYYYFDPLSGEMVVGWQY

IPAPHKGVTIGPSPRIEIALRPDWFYFGQDGVLQEFVGKQVLEAKTATNTNKHHGEEYDSQAEKRVYYFEDQRSYHT

LKTGWIYEEGHWYYLQKDGGFDSRINRLTVGELARGWVKDYPLTYDEEKLKAAPWYYLNPATGIMQTGWQYLGNRWY

YLHSSGAMATGWYKEGSTWYYLDAENGDMRTGWQNLGNKWYYLRSSGAMATGWYQESSTWYYLNASNGDMKTGWFQV

NGNWYYAYDSGALAVNTTVGGYYLNYNGEWVKZ

ID306

TTGGCTGGTAGATATGGTTCTGCTGTTCAGTGTACAGAAGTGACTGCCTCAAACCTTTCAACAGTTAAAACTAAAGC

TACGGTTGTAGAAAAACCACTGAAAGATTTTAGAGCGTCTACGTCTGATCAGTCTGGTTGGGTGGAATCTAATGGTA

AATGGTATTTCTATGAGTCTGGTGATGTGAAGACAGGTTGGGTGAAAACAGATGGTAAATGGTACTATTTGAATGAC

TTAGGTGTCATGCAGACTGGATTTGTAAAATTTTCTGGTAGCTGGTATTACTTGAGCAATTCAGGTGCTATGTTTAC

AGGCTGGGGAACAGATGGTAGCAGATGGTTCTACTTTGACGGCTCAGGAGCTATGAAGACAGGCTGGTACAAGGAAA

ATGGCACTTGGTATTACCTTGACGAAGCAGGTATCATGAAGACAGGTTGGTTTAAAGTCGGACCACACTGGTACTAT

GCCTACGGTTCAGGAGCTTTGGCTGTGAGCACAACAACACCAGATGGTTACCGTGTAAATGGTAATGGTGAATGGGT

AAACTAG

LAGRYGSAVQCTEVTASNLSTVKTKATVVEKPLKDFRASTSDQSGWVESNGKWYFYESGDVKTGWVKTDGKWYYLND

LGVMQTGFVKFSGSWYYLSNSGAMFTGWGTDGSRWFYFDGSGAMKTGWYKENGTWYYLDEAGIMKTGWFKVGPHWYY

AYGSGALAVSTTTPDGYRVNGNGEWVNZ

ID307

ATGAAAATTTTGAAAAAAACTATGCAAGTTGGACTGACAGTATTTTTCTTTGGTTTGCTAGGGACCAGTACAGTATT

TGCAGATGATTCTGAAGGATGGCAGTTTGTCCAAGAAAACGGAAGAACCTACTACAAAAAGGGGGACCTCAAAGAAA

CCTACTGGCGAGTGATTGATGGTAAGTACTATTATTTTGATTCTCTATCTGGAGAGATGGTTGTCGGCTGGCAATAT

ATCCCGTTTCCATCTAAAGGTAGTACAATTGGTCCTTACCCAAATGGTATCAGATTAGAAGGTTTTCCAAAGTCAGA

GTGGTACTACTTCGATAAAAATGGAGTGCTACAAGAGTTTGTTGGTTGGAAAACATTAGAGATTAAAACTAAAGACA

GTGTTGGAAGAAAGTACGGGGAAAAACGTGAAGATTCAGAAGATAAAGAAGAGAAGCGTTATTATACGAACTATTAC

TTTAATCAAAATCATTCTTTAGAGACAGGTTGGCTTTATGATCAGTCTAACTGGTATTATCTAGCTAAGACGGAAAT

TAATGGAGAAAACTACCTTGGTGGTGAAAGACGTGCGGGGTGGATAAACGATGATTCGACTTGGTACTACCTAGATC

CAACAACTGGTATTATGCAAACAGGTTGGCAATATCTAGGTAATAAGTGGTACTACCTCCGTTCCTCAGGAGCAATG

GCCACTGGCTGGTATCAGGAAGGTACCACTTGGTATTATTTAGACCACCCAAATGGCGATATGAAAACAGGTTGGCA

AAACCTTGGGAACAAATGGTACTATCTCCGTTCATCAGGAGCTATGGCAACTGGTTGGTATCAAGATGGTTCAACTT

GGTACTACCTAAATGCAGGTAATGGAGACATGAAGACAGGTTGGTTCCAGGTCAATGGCAACTGGTACTATGCTTAT

AGCTCAGGTGCTTTGGCAGTGAATACGACCGTAGATGGCTATTCTGTCAACTATAATGGCGAATGGGTTCGGTAA

MKILKKTMQVGLTVFFFGLLGTSTVFADDSEGWQFVQENGRTYYKKGDLKETYWRVIDGKYYYFDSLSGEMVVGWQY

IPFPSKGSTIGPYPNGIRLEGFPKSEWYYFDKNGVLQEFVGWKTLEIKTKDSVGRKYGEKREDSEDKEEKRYYTNYY

FNQNHSLETGWLYDQSNWYYLAKTEINGENYLGGERRAGWINDDSTWYYLDPTTGIMQTGWQYLGNKWYYLRSSGAM

ATGWYQEGTTWYYLDHPNGDMKTGWQNLGNKWYYLRSSGAMATGWYQDGSTWYYLNAGNGDMKTGWFQVNGNWYYAY

SSGALAVNTTVDGYSVNYNGEWVRZ

ID308

ATGAAAAAGAAATTAACTAGTTTAGCACTTGTAGGCGCTTTTTTAGGTTTGTCATGGTATGGGAATGTTCAGGCTCA

AGAAAGTTCAGGAAATAAAATCCACTTTATCAATGTTCAAGAAGGTGGCAGTGATGCGATTATTCTTGAAAGCAATG

GACATTTTGCCATGGTGGATACAGGAGAAGATTATGATTTCCCAGATGGAAGTGATTCTCGCTATCCATGGAGAGAA

GGAATTGAAACGTCTTATAAGCATGTTCTAACAGACCGTGTCTTTCGTCGTTTGAAGGAATTGGGTGTCCAAAAACT

TGATTTTATTTTGGTGACCCATACCCACAGTGATCATATTGGAAATGTTGATGAATTACTGTCTACCTATCCAGTTG

ACCGAGTCTATCTTAAGAAATATAGTGATAGTCGTATTACTAATTCTGAACGTCTATGGGATAATCTGTATGGCTAT

GATAAGGTTTTACAGACTGCTGCAGAAAAAGGTGTTTCAGTTATTCAAAATATCACACAAGGGGATGCTCATTTTCA

GTTTGGGGACATGGATATTCAGCTCTATAATTATGAAAATGAAACTGATTCATCGGGTGAATTAAAGAAAATTTGGG

ATGACAATTCCAATTCCTTGATTAGCGTGGTGAAAGTCAATGGCAAGAAAATTTACCTTGGGGGCGATTTAGATAAT

GTTCATGGAGCAGAAGACAAGTATGGTCCTCTCATTGGAAAAGTTGATTTGATGAAGTTTAATCATCACCATGATAC

CAACAAATCAAATACCAAGGATTTCATTAAAAATTTGAGTCCGAGTTTGATTGTTCAAACTTCGGATAGTCTACCTT

GGAAAAATGGTGTTGATAGTGAGTATGTTAATTGGCTCAAAGAACGAGGAATTGAGAGAATCAACGCAGCCAGCAAA

GACTATGATGCAACAGTTTTTGATATTCGAAAAGACGGTTTTGTCAATATTTCAACATCCTACAAGCCGATTCCAAG

TTTTCAAGCTGGTTGGCATAAGAGTGCATATGGGAACTGGTGGTATCAAGCGCCTGATTCTACAGGAGAGTATGCTG

TCGGTTGGAATGAAATCGAAGGTGAATGGTATTACTTTAACCAAACGGGTATCTTGTTACAGAATCAATGGAAAAAA

TGGAACAATCATTGGTTCTATTTGACAGACTCTGGTGCTTCTGCTAAAAATTGGAAGAAAATCGCTGGAATCTGGTA

TTATTTTAACAAAGAAAACCAGATGGAAATTGGTTGGATTCAAGATAAAGAGCAGTGGTATTATTTGGATGTTGATG

GTTCTATGAAGACAGGATGGCTTCAATATATGGGGCAATGGTATTACTTTGCTCCATCAGGGGAAATGAAAATGGGC

TGGGTAAAAGATAAAGAAACCTGGTACTATATGGATTCTACTGGTGTCATGAAGACAGGTGAGATAGAAGTTGCTGG

TCAACATTATTATCTGGAAGATTCAGGAGCTATGAAGCAAGGCTGGCATAAAAAGGCAAATGATTGGTATTTCTACA

AGACAGACGGTTCACGAGCTGTGGGTTGGATCAAGGACAAGGATAAATGGTACTTCTTGAAAGAAAATGGTCAATTA

CTTGTGAACGGTAAGACACCAGAAGGTTATACTGTGGATTCAAGTGGTGCCTGGTTAGTGGATGTTTCGATCGAGAA

ATCTGCTACAATTAAAACTACAAGTCATTCAGAAATAAAAGAATCCAAAGAAGTAGTGAAAAAGGATCTTGAAAATA

AAGAAACGAGTCAACATGAAAGTGTTACAAATTTTTCAACTAGTCAAGATTTGACATCCTCAACTTCACAAAGCTCT

GAAACGAGTGTAAACAAATCGGAATCAGAACAGTAG

MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSDAIILESNGHFAMVDTGEDYDFPDGSDSRYPWRE

GIETSYKHVLTDRVFRRLKELGVQKLDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGY

DKVLQTAAEKGVSVIQNITQGDAHFQFGDMDIQLYNYENETDSSGELKKIWDDNSNSLISVVKVNGKKIYLGGDLDN

VHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQTSDSLPWKNGVDSEYVNWLKERGIERINAASK

DYDATVFDIRKDGFVNISTSYKPIPSFQAGWHKSAYGNWWYQAPDSTGEYAVGWNEIEGEWYYFNQTGILLQNQWKK

WNNHWFYLTDSGASAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYMGQWYYFAPSGEMKMG

WVKDKETWYYMDSTGVMKTGEIEVAGQHYYLEDSGAMKQGWHKKANDWYFYKTDGSRAVGWIKDKDKWYFLKENGQL

LVNGKTPEGYTVDSSGAWLVDVSIEKSATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNFSTSQDLTSSTSQSS

ETSVNKSESEQZ

ID309

ATGGAAATTAATGTGAGTAAATTAAGAACAGATTTGCCTCAAGTCGGCGTGCAACCATATAGGCAAGTACACGCACA

CTCAACTGGGAATCCGCATTCAACCGTACAGAATGAAGCGGATTATCACTGGCGGAAAGACCCAGAATTAGGTTTTT

TCTCGCACATTGTTGGGAACGGTGGCATCATGCAGGTAGGACCTGTTGATAATGGTGCCTGGGACGTTGGGGGCGGT

TGGAATGCTGAGACCTATGCAGCGGTTGAACTGATTGAAAGCCATTCAACCAAAGAAGAGTTCATGACGGACTACCG

CCTTTATATCGAACTCTTACGCAATCTAGCAGATGAAGCAGGTTTGCCGAAAACGCTTGATACAGGGAGTTTAGCTG

GAATTAAAACGCACGAGTATTGCACGAATAACCAACCAAACAACCACTCAGACCACGTTGACCCTTATCCATATCTT

GCTAAATGGGGCATTAGCCGTGAGCAGTTTAAGCATGATATTGAGAACGGCTTGACGATTGAAACAGGCTGGCAGAA

GAATGACACTGGCTACTGGTACGTACATTCAGACGGCTCTTATCCAAAAGACAAGTTTGAGAAAATCAATGGCACTT

GGTACTACTTTGACAGTTCAGGCTATATGCTTGCAGACCGCTGGAGGAAGCACACAGACGGCAACTGGTACTGGTTC

GACAACTCAGGCGAAATGGCTACAGGCTGGAAGAAAATCGCTGATAAGTGGTACTATTTCAACGAAGAAGGTGCCAT

GAAGACAGGCTGGGTCAAGTACAAGGACACTTGGTACTACTTAGACGCTAAAGAAGGCGCCATGGTATCAAATGCCT

TTATCCAGTCAGCGGACGGAACAGGCTGGTACTACCTCAAACCAGACGGAACACTGGCAGACAAGCCAGAATTCACA

GTAGAGCCAGATGGCTTGATTACAGTAAAATAA

MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGG

WNAETYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYL

AKWGISREQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLADRWRKHTDGNWYWF

DNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFT

VEPDGLITVKZ

ID310

ATGGGCACAACAGGATTTACAATAATTGACTTAATTATCTTGATTGTTTATTTACTTGCGGTGTTGGTTGCAGGTAT

CTATTTCTCTAAAAAAGAGATGAAAGGAAAAGAGTTCTTTAAAGGAGATGGTTCGGTTCCTTGGTATGTTACTTCGG

TATCCATTTTTGCCACAATGCTCAGTCCGATTTCCTTCTTGGGACTCGCTGGTAGCTCTTATGCAGGTAGCTGGATT

TTATGGTTTGCTCAATTAGGGATGGTAGTAGCTATTCCACTGACAATTCGTTTTATCTTACCTATCTTTGCACGGAT

AGACATCGATACGGCATATGATTACTTGGATAAACGTTTTAATTCTAAAGCACTTCGTATTATTTCAGCACTCTTGT

TTATTATTTATCAATTGGGACGTATGTCTATCATTATGTACCTCCCATCAGCTGGTTTATCAGTATTGACAGGAATT

GACATCAATATTTTGATTATTTTGATGGGTGTAGTTGCAATTGTTTATTCTTATACTGGTGGTCTAAAATCCGTATT

ATGGACAGACTTTATTCAAGGTGTGATTCTGATTAGTGGTGTCGTTTTAGCTTTATTTGTACTGATTGCTAATATTA

AAGGTGGCTTTGGTGCAGTAGCAGAAACATTAGCAAACGGGAAATTCCTTGCTGCAAATGAAAAACTTTTCGATCCT

AACTTGCTTTCAAACTCCATCTTTTTAATTGTGATGGGTTCAGGCTTTACAATCTTGTCTTCCTATGCTTCATCTCA

AGATTTGGTTCAACGTTTTACTACAACACAAAATATTAAGAAACTTAATAAGATGTTGTTCACAAACGGTGTTTTGT

CACTTGCAACTGCAACAGTCTTTTACTTGATTGGTACAGGCTTGTACGTATTCTATCAAGTACAAAATGCAGATAGT

GCAGCTAGCAATATCCCTCAAGACCAAATCTTTATGTACTTTATTGCATACCAGTTACCAGTAGGTATCACAGGTTT

GATCTTGGCAGCGATTTATGCAGCATCTCAATCAACTATTTCAACAGGTTTGAACTCTGTTGCAACTTCATGGACAT

TGGATATTCAAGATGTCATTTCTAAAAATATGTCAGACAATCGTCGTACGAAAATTGCACAATTCGTATCTCTAGCA

GTAGGTTTATTCTCAATTGGTGTTTCCATTGTCATGGCTCACTCAGATATTAAATCTGCATACGAATGGTTCAATAG

TTTCATGGGACTTGTACTTGGTCTACTTGGTGGTGTATTTATTCTTGGATTTGTTTCTAAAAAAGCAAATAAACAAG

GTGCTTATGCAGCGCTGATTGTATCAACCATCGTCATGGTATTTATTAAATACTTCCTTCCTCCAACAGCTGTTAGC

TACTGGGCATATTCATTGATTTCAATCTCTGTATCAGTAGTTTCAGGTTATATTGTATCTGTTCTTACTGGAAATAA

AGTATCTGCACCTAAATATACAACGATTCATGATATTACAGAAATTAAAGCGGATTCAAGTTGGGAAGTTCGTCACT

AA

MGTTGFTIIDLIILIVYLLAVLVAGIYFSKKEMKGKEFFKGDGSVPWYVTSVSIFATMLSPISFLGLAGSSYAGSWI

LWFAQLGMVVAIPLTIRFILPIFARIDIDTAYDYLDKRFNSKALRIISALLFIIYQLGRMSIIMYLPSAGLSVLTGI

DINILIILMGVVAIVYSYTGGLKSVLWTDFIQGVILISGVVLALFVLIANIKGGFGAVAETLANGKFLAANEKLFDP

NLLSNSIFLIVMGSGFTILSSYASSQDLVQRFTTTQNIKKLNKMLFTNGVLSLATATVFYLIGTGLYVFYQVQNADS

AASNIPQDQIFMYFIAYQIPVGITGLILAAIYAASQSTISTGLNSVATSWTLDIQDVISKNMSDNRRTKIAQFVSLA

VGLFSIGVSIVMAHSDIKSAYEWFNSFMGLVLGLLGGVFILGFVSKKANKQGAYAALIVSTIVMVFIKYFLPPTAVS

YWAYSLISISVSVVSGYIVSVLTGNKVSAPKYTTIHDITEIKADSSWEVRHZ

ID311

ATGAAAATTAATAAAAAATATCTAGCAGGTTCAGTGGCAGTCCTTGCCCTAAGTGTTTGTTCCTATGAGCTTGGTCG

TCACCAAGCTGGTCAGGATAAGAAAGAGTCTAATCGAGTTGCTTATATAGATGGTGATCAGGCTGGTCAAAAGGCAG

AAAACTTGACACCAGATGAAGTCAGTAAGAGGGAGGGGATCAACGCCGAACAAATCGTCATCAAGATTACGGATCAA

GGTTATGTGACCTCTCATGGAGACCATTATCATTACTATAATGGCAAGGTCCCTTATGATGCCATCATCAGTGAAGA

GCTCCTCATGAAAGATCCGAATTATCAGTTGAAGGATTCAGACATTGTCAATGAAATCAAGGGTGGTTATGTCATCA

AGGTAGACGGAAAATACTATGTTTACCTTAAGGATGCAGCTCATGCGGATAATATTCGGACAAAAGAAGAGATTAAA

CGTCAGAAGCAGGAACGCAGTCATAATCACGGGTCAGGAGCTAACGATCATGCAGTAGCTGCAGCCAGAGCCCAAGG

ACGCTATACAACGGATGATGGGTATATCTTCAATGCATCTGATATCATTGAGGACACGGGTGATGCTTATATCGTTC

CTCACGGCGACCATTACCATTACATTCCTAAGAATGAGTTATCAGCTAGCGAGTTAGCTGCTGCAGAAGCCTATTGG

AATGGGAAGCAGGGATCTCGTCCTTCTTCAAGTTCTAGTTATAATGCAAATCCAGCTCAACCAAGATTGTCAGAGAA

CCACAATCTGACTGTCACTCCAACTTATCATCAAAATCAAGGGGAAAACATTTCAAGCCTTTTACGTGAATTGTATG

CTAAACCCTTATCAGAACGCCATGTGGAATCTGATGGCCTTATTTTCGACCCAGCGCAAATCACAAGTCGAACCGCC

AGAGGTGTAGCTGTCCCTCATGGTAACCATTACCACTTTATCCCTTATGAACAAATGTCTGAATTGGAAAAACGAAT

TGCTCGTATTATTCCCCTTCGTTATCGTTCAAACCATTGGGTACCAGATTCAAGACCAGAACAACCAAGTCCACAAT

CGACTCCGGAACCTAGTCCAAGTCCGCAACCTGCACCAAATCCTCAACCAGCTCCAAGCAATCCAATTGATGAGAAA

TTGGTCAAAGAAGCTGTTCGAAAAGTAGGCGATGGTTATGTCTTTGAGGAGAATGGAGTTTCTCGTTATATCCCAGC

CAAGGATCTTTCAGCAGAAACAGCAGCAGGCATTGATAGAAACTGGCCAAGCAGGAAAGTTTATCTCATAAGCTAG

GAGCTAAGAAAACTGACCTCCCATCTAGTGATCGAGAATTTTACAATAAGGCTTATGACTTACTAGCAAGAATTCAC

CAAGATTTACTTGATAATAAAGGTCGACAAGTTGATTTTGAGGCTTTGGATAACCTGTTGGAACGACTCAAGGATGT

CCCAAGTGATAAAGTCAAGTTAGTGGATGATATTCTTGCCTTCTTAGCTCCGATTCGTCATCCAGAACGTTTAGGAA

AACCAAATGCGCAAATTACCTACACTGATGATGAGATTCAAGTAGCCAAGTTGGCAGGCAAGTACACAACAGAAGAC

GGTTATATCTTTGATCCTCGTGATATAACCAGTGATGAGGGGGATGCCTATGTAACTCCACATATGACCCATAGCCA

CTGGATTAAAAAAGATAGTTTGTCTGAAGCTGAGAGAGCGGCAGCCCAGGCTTATGCTAAAGAGAAAGGTTTGACCC

CTCCTTCGACAGACCATCAGGATTCAGGAAATACTGAGGAAAAGGAGCAGAAGCTATCTACAACCGCGTGAAAGCA

GCTAAGAAGGTGCCACTTGATCGTATGCCTTACAATCTTCAATATACTGTAGAAGTCAAAAACGGTAGTTTAATCAT

ACCTCATTATGACCATTACCATAACATCAAATTTGAGTGGTTTGACGAAGGCCTTTATGAGGCACCTAAGGGGTATA

CTCTTGAGGATCTTTTGGCGACTGTCAAGTACTATGTCGAACATCCAAACGAACGTCCGCATTCAGATAATGGTTTT

GGTAACGCTAGCGACCATGTTCAAAGAAACAAAAATGGTCAAGCTGATACCAATCAAACGGAAAAACCAAGCGAGGA

GAAACCTCAGACAGAAAAACCTGAGGAAGAAACCCCTCGAGAAGAGAAACCGCAAAGCGAGAAACCAGAGTCTCCAA

AACCAACAGAGGAACCAGAAGAATCACCAGAGGAATCAGAAGAACCTCAGGTCGAGACTGAAAAGGTTGAAGAAAAA

CTGAGAGAGGCTGAAGATTTACTTGGAAAAATCCAGGATCCAATTATCAAGTCCAATGCCAAAGAGACTCTCACAGG

ATTAAAAAATAATTTACTATTTGGCACCCAGGACAACAATACTATTATGGCAGAAGCTGAAAAACTATTGGCTTTAT

TAAAGGAGAGTAAGTAA

MKINKKYLAGSVAVLALSVCSYELGRHQAGQDKKESNRVAYIDGDQAGQKAENLTPDEVSKREGINAEQIVIKITDQ

GYVTSHGDHYHYYNGKVPYDAIISEELLMKIDPNYQLKDSDIVNEIKGGYVIKVDGKYYYYLKDAAHADNIRTKEEIK

RQKQERSHNHGSGANDHAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAAEAYW

NGKQGSRPSSSSSYNANPAQPRLSENHNLTVTPTYHQNQGENISSLLRELYAKPLSERHVESDGLIFDPAQITSRTA

RGVAVPHGNHYHFIPYEQMSELEKRIARIIPLRYRSNHWVPDSRPEQPSPQSTPEPSPSPQPAPNPQPAPSNPIDEK

LVKEAVRKVGDGYVFEENGVSRYIPAKDLSAETAAGIDSKLAKQESLSHKLGAKKTDLPSSDREFYNKAYDLLARIH

QDLLDNKGRQVDFEALDNLLERLKDVPSDKVKLVDDILAFLAPIRHPERLGKPNAQITYTDDEIQVAKLAGKYTTED

GYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKA

AKKVPLDRMPYNLQYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYFAPKGYTLEDLLATVKYYVEHPNERPHSDNGF

GNASDHVQRNKNGQADTNQTEKPSEEKPQTEKPEEETPREEKPQSEKPESPKPTEEPEESPEESEEPQVETEKVEEK

LREAEDLLGKIQDPIIKSNAKETLTGLKNNLLFGTQDNNTIMAEAEKLLALLKESKZ

ID312

ATGGAGGGATTGGTTAGAGTGCATTTATTGCCTGTATTTGGCGATTACAAGCTATCTAAACTTACTACGCCTATTCT

TCAACAGCAAGTAAACAAATGGGCTGACAAGGCAAATAAAGGCGAAAAAGGGGCATTTGCTAACTACTCTTTGCTCC

ATAACATGAATAAGCGTATTTTGAAATATGGCGTAGCTATCCAGGTAATACAATACAACCCAGCTAATGATGTCATC

GTTCCACGCAAACAGCAAAAAGAAAAGGCTGCTGTCAAATACTTAGACAACAAAGAATTAAAACAGTTTCTTGATTA

TTTAGATGCTCTGGATCAATCAAATTATGAGAACTTATTTGATGTTGTTCTGTATAAGACTTTATTGGCCACTGGTT

GCCGTATTAGTGAGGCTCTGGCTCTTGAATGGTCTGATATTGACCTAGAAAGCGGTGTTATCAGCATCAATAAGACA

CTAAACCGCTATCAGGAAATAAACTCACCTAAATCAAGCGCTGGTTATCGTGATATACCAATAGACAAAGCCACATT

ACTTTTACTGAAACAATACAAAAACCGTCAACAAATTCAGTCTTGGAAATTAGGCCGATCTGAAACAGTTGTATTCT

CTGTATTTACGGAGAAATATGCTTATGCTTGTAACTTACGCAAACGCCTAAATAAGCATTTTGATGCTGCTGGAGTA

ACTAACGTATCATTTCATGGTTTCCGCCATACACATACTACTATGATGCTCTATGCTCAGGTTAGCCCGAAAGATGT

TCAGTATAGATTAGGCCACTCTAATTTAATGATCACTGAAAATACTTACTGGCATACTAACCAAGAGAATGCAAAAA

AAGCCGTCTCAAATTATGAAACAGCTATCAACAATTTATAA

MEGLVRVHLLPVFGDYKLSKLTTPILQQQVNKWADKANKGEKGAFANYSLLHNMNKRILKYGVAIQVIQYNPANDVI

VPRKQQKEKAAVKYLDNKELKQFLDYLDALDQSNYENLFDVVLYKTLLATGCRISEALALEWSDIDLESGVISINKT

LNRYQEINSPKSSAGYRDIPIDKATLLLLKQYKNRQQIQSWKLGRSETVVFSVFTEKYAYACNLRKRLNKHFDAAGV

TNVSFHGFRHTHTTMMLYAQVSPKDVQYRLGHSNLMITENTYWHTNQENAKKAVSNYETAINNLZ

Sequence table

<110>Microbial?Technics?Limited

Gilbert，Christophe?FG

Hansbro，Philip?M

<120>Proteins

<130>PWC/P21129W0

<140>PCT/GB99/02451

<141>1999-07-27

<150>GB?9816337.1

<151>1998-03-27

<150>US?60/125164

<151>1999-03-19

<160>388

<170>PatentIn?Ver.2.1

<210>1

<211>207

<212>PRT

＜213〉streptococcus pneumoniae

<400>1

Met?Glu?Glu?Leu?Val?Thr?Leu?Asp?Cys?Leu?Phe?Ile?Asp?Arg?Thr?Lys

1 5 10 15

Ile?Glu?Ala?Asn?Ala?Asn?Lys?Tyr?Ser?Phe?Val?Trp?Lys?Lys?Thr?Thr

20 25 30

Glu?Lys?Phe?Ser?Ala?Lys?Leu?Gln?Glu?Gln?Ile?Gln?Val?Tyr?Phe?Gln

35 40 45

Glu?Glu?Ile?Thr?Pro?Leu?Leu?Ile?Lys?Tyr?Ala?Met?Phe?Asp?Lys?Lys

50 55 60

Gln?Lys?Arg?Gly?Tyr?Lys?Glu?Ser?Ala?Lys?Asn?Leu?Ala?Asn?Trp?His

65 70 75 80

Tyr?Asn?Asp?Lys?Glu?Asp?Ser?Tyr?Thr?His?Pro?Asp?Gly?Trp?Tyr?Tyr

85 90 95

Arg?Phe?His?His?Thr?Lys?Tyr?Gln?Lys?Thr?Gln?Thr?Asp?Phe?Gln?Gln

100 105 110

Glu?Ile?Lys?Val?Tyr?Tyr?Ala?Asp?Glu?Pro?Glu?Ser?Ala?Pro?Gln?Lys

115 120 125

Gly?Leu?Tyr?Met?Asn?Glu?Arg?Tyr?Gln?Asn?Leu?Lys?Ala?Lys?Glu?Cys

130 135 140

Gln?Ala?Leu?Leu?Ser?Pro?Gln?Gly?Arg?Gln?Ile?Phe?Ala?Gln?Arg?Lys

145 150 155 160

Ile?Asp?Val?Glu?Pro?Val?Phe?Gly?Gln?Ile?Lys?Ala?Ser?Leu?Gly?Tyr

165 170 175

Lys?Arg?Cys?Asn?Leu?Arg?Gly?Lys?Arg?Gln?Val?Arg?Ile?Asp?Met?Gly

180 185 190

Leu?Val?Leu?Met?Ala?Asn?Asn?Leu?Leu?Lys?Tyr?Ser?Lys?Met?Lys

195 200 205

<210>2

<211>2233

<212>PRT

＜213〉streptococcus pneumoniae

<400>2

Met?Gly?Lys?Gly?His?Trp?Asn?Arg?Lys?Arg?Val?Tyr?Ser?Ile?Arg?Lys

1 5 10 15

Phe?Ala?Val?Gly?Ala?Cys?Ser?Val?Met?Ile?Gly?Thr?Cys?Ala?Val?Leu

20 25 30

Leu?Gly?Gly?Asn?Ile?Ala?Gly?Glu?Ser?Val?Val?Tyr?Ala?Asp?Glu?Thr

35 40 45

Leu?Ile?Thr?His?Thr?Ala?Glu?Lys?Pro?Lys?Glu?Glu?Lys?Met?Ile?Val

50 55 60

Glu?Glu?Lys?Ala?Asp?Lys?Ala?Leu?Glu?Thr?Lys?Asn?Ile?Val?Glu?Arg

65 70 75 80

Thr?Glu?Gln?Ser?Glu?Pro?Ser?Ser?Thr?Glu?Ala?Ile?Ala?Ser?Glu?Lys

85 90 95

Lys?Glu?Asp?Glu?Ala?Val?Thr?Pro?Lys?Glu?Glu?Lys?Val?Ser?Ala?Lys

100 105 110

Pro?Glu?Glu?Lys?Ala?Pro?Arg?Ile?Glu?Ser?Gln?Ala?Ser?Asn?Gln?Glu

115 120 125

Lys?Pro?Leu?Lys?Glu?Asp?Ala?Lys?Ala?Val?Thr?Asn?Glu?Glu?Val?Asn

130 135 140

Gln?Met?Ile?Glu?Asp?Arg?Lys?Val?Asp?Phe?Asn?Gln?Asn?Trp?Tyr?Phe

145 150 155 160

Lys?Leu?Asn?Ala?Asn?Ser?Lys?Glu?Ala?Ile?Lys?Pro?Asp?Ala?Asp?Val

165 170 175

Ser?Thr?Trp?Lys?Lys?Leu?Asp?Leu?Pro?Tyr?Asp?Trp?Ser?Ile?Phe?Asn

180 185 190

Asp?Phe?Asp?His?Glu?Ser?Pro?Ala?Gln?Asn?Glu?Gly?Gly?Gln?Leu?Asn

195 200 205

Gly?Gly?Glu?Ala?Trp?Tyr?Arg?Lys?Thr?Phe?Lys?Leu?Asp?Glu?Lys?Asp

210 215 220

Leu?Lys?Lys?Asn?Val?Arg?Leu?Thr?Phe?Asp?Gly?Val?Tyr?Met?Asp?Ser

225 230 235 240

Gln?Val?Tyr?Val?Asn?Gly?Gln?Leu?Val?Gly?His?Tyr?Pro?Asn?Gly?Tyr

245 250 255

Asn?Gln?Phe?Ser?Tyr?Asp?Ile?Thr?Lys?Tyr?Leu?Gln?Lys?Asp?Gly?Arg

260 265 270

Glu?Asn?Val?Ile?Ala?Val?His?Ala?Val?Asn?Lys?Gln?Pro?Ser?Ser?Arg

275 280 285

Trp?Tyr?Ser?Gly?Ser?Gly?Ile?Tyr?Arg?Asp?Val?Thr?Leu?Gln?Val?Thr

290 295 300

Asp?Lys?Val?His?Val?Glu?Lys?Asn?Gly?Thr?Thr?Ile?Leu?Thr?Pro?Lys

305 310 315 320

Leu?Glu?Glu?Gln?Gln?His?Gly?Lys?Val?Glu?Thr?His?Val?Thr?Ser?Lys

325 330 335

Ile?yal?Asn?Thr?Asp?Asp?Lys?Asp?His?Glu?Leu?Val?Ala?Glu?Tyr?Gln

340 345 350

Ile?Val?Glu?Arg?Gly?Gly?His?Ala?Val?Thr?Gly?Leu?Val?Arg?Thr?Ala

355 360 365

Ser?Arg?Thr?Leu?Lys?Ala?His?Glu?Ser?Thr?Ser?Leu?Asp?Ala?Ile?Leu

370 375 380

Glu?Val?Glu?Arg?Pro?Lys?Leu?Trp?Thr?Val?Leu?Asn?Asp?Lys?Pro?Ala

385 390 395 400

Leu?Tyr?Glu?Leu?Ile?Thr?Arg?Val?Tyr?Arg?Asp?Gly?Gln?Leu?Val?Asp

405 410 415

Ala?Lys?Lys?Asp?Leu?Phe?Gly?Tyr?Arg?Tyr?Tyr?His?Trp?Thr?Pro?Asn

420 425 430

Glu?Gly?Phe?Ser?Leu?Asn?Gly?Glu?Arg?Ile?Lys?Phe?His?Gly?Val?Ser

435 440 445

Leu?His?His?Asp?His?Gly?Ala?Leu?Gly?Ala?Glu?Glu?Asn?Tyr?Lys?Ala

450 455 460

Glu?Tyr?Arg?Arg?Leu?Lys?Gln?Met?Lys?Glu?Met?Gly?Val?Asn?Ser?Ile

465 470 475 480

Arg?Thr?Thr?His?Asn?Pro?Ala?Ser?Glu?Gln?Thr?Leu?Gln?Ile?Ala?Ala

485 490 495

Glu?Leu?Gly?Leu?Leu?Val?Gln?Glu?Glu?Ala?Phe?Asp?Thr?Trp?Tyr?Gly

500 505 510

Gly?Lys?Lys?Pro?Tyr?Asp?Tyr?Gly?Arg?Phe?Phe?Glu?Lys?Asp?Ala?Thr

515 520 525

His?Pro?Glu?Ala?Arg?Lys?Gly?Glu?Lys?Trp?Ser?Asp?Phe?Asp?Leu?Arg

530 535 540

Thr?Met?Val?Glu?Arg?Gly?Lys?Asn?Asn?Pro?Ala?Ile?Phe?Met?Trp?Ser

545 550 555 560

Ile?Gly?Asn?Glu?Ile?Gly?Glu?Ala?Asn?Gly?Asp?Ala?His?Ser?Leu?Ala

565 570 575

Thr?Val?Lys?Arg?Leu?Val?Lys?Val?Ile?Lys?Asp?Val?Asp?Lys?Thr?Arg

580 585 590

Tyr?Val?Thr?Met?Gly?Ala?Asp?Lys?Phe?Arg?Phe?Gly?Asn?Gly?Ser?Gly

595 600 605

Gly?His?Glu?Lys?Ile?Ala?Asp?Glu?Leu?Asp?Ala?Val?Gly?Phe?Asn?Tyr

610 615 620

Ser?Glu?Asp?Asn?Tyr?Lys?Ala?Leu?Arg?Ala?Lys?His?Pro?Lys?Trp?Leu

625 630 635 640

Ile?Tyr?Gly?Ser?Glu?Thr?Ser?Ser?Ala?Thr?Arg?Thr?Arg?Gly?Ser?Tyr

645 650 655

Tyr?Arg?Pro?Glu?Arg?Glu?Leu?Lys?His?Ser?Asn?Gly?Pro?Glu?Arg?Asn

660 665 670

Tyr?Glu?Gln?Ser?Asp?Tyr?Gly?Asn?Asp?Arg?Val?Gly?Trp?Gly?Lys?Thr

675 680 685

Ala?Thr?Ala?Ser?Trp?Thr?Phe?Asp?Arg?Asp?Asn?Ala?Gly?Tyr?Ala?Gly

690 695 700

Gln?Phe?Ile?Trp?Thr?Gly?Thr?Asp?Tyr?Ile?Gly?Glu?Pro?Thr?Pro?Trp

705 710 715 720

His?Asn?Gln?Asn?Gln?Thr?Pro?Val?Lys?Ser?Ser?Tyr?Phe?Gly?Ile?Val

725 730 735

Asp?Thr?Ala?Gly?Ile?Pro?Lys?His?Asp?Phe?Tyr?Leu?Tyr?Gln?Ser?Gln

740 745 750

Trp?Val?Ser?Val?Lys?Lys?Lys?Pro?Met?Val?His?Leu?Leu?Pro?His?Trp

755 760 765

Asn?Trp?Glu?Asn?Lys?Glu?Leu?Ala?Ser?Lys?Val?Ala?Asp?Ser?Glu?Gly

770 775 780

Lys?Ile?Pro?Val?Arg?Ala?Tyr?Ser?Asn?Ala?Ser?Ser?Val?Glu?Leu?Phe

785 790 795 800

Leu?Asn?Gly?Lys?Ser?Leu?Gly?Leu?Lys?Thr?Phe?Asn?Lys?Lys?Gln?Thr

805 810 815

Ser?Asp?Gly?Arg?Thr?Tyr?Gln?Glu?Gly?Ala?Asn?Ala?Asn?Glu?Leu?Tyr

820 825 830

Leu?Glu?Trp?Lys?Val?Ala?Tyr?Gln?Pro?Gly?Thr?Leu?Glu?Ala?Ile?Ala

835 840 845

Arg?Asp?Glu?Ser?Gly?Lys?Glu?Ile?Ala?Arg?Asp?Lys?Ile?Thr?Thr?Ala

850 855 860

Gly?Lys?Pro?Ala?Ala?Val?Arg?Leu?Ile?Lys?Glu?Asp?His?Ala?Ile?Ala

865 870 875 880

Ala?Asp?Gly?Lys?Asp?Leu?Thr?Tyr?Ile?Tyr?Tyr?Glu?Ile?Val?Asp?Ser

885 890 895

Gln?Gly?Asn?Val?Val?Pro?Thr?Ala?Asn?Asn?Leu?Val?Arg?Phe?Gln?Leu

900 905 910

His?Gly?Gln?Gly?Gln?Leu?Val?Gly?Val?Asp?Asn?Gly?Glu?Gln?Ala?Ser

915 920 925

Arg?Glu?Arg?Tyr?Lys?Ala?Gln?Ala?Asp?Gly?Ser?Trp?Ile?Arg?Lys?Ala

930 935 940

Phe?Asn?Gly?Lys?Gly?Val?Ala?Ile?Val?Lys?Ser?Thr?Glu?Gln?Ala?Gly

945 950 955 960

Lys?Phe?Thr?Leu?Thr?Ala?His?Ser?Asp?Leu?Leu?Lys?Ser?Asn?Gln?Val

965 970 975

Thr?Val?Phe?Thr?Gly?Lys?Lys?Glu?Gly?Gln?Glu?Lys?Thr?Val?Leu?Gly

980 985 990

Thr?Glu?Val?Pro?Lys?Val?Gln?Thr?Ile?Ile?Gly?Glu?Ala?Pro?Glu?Met

995 1000 1005

Pro?Thr?Thr?Val?Pro?Phe?Val?Tyr?Ser?Asp?Gly?Ser?Arg?Ala?Glu?Arg

1010 1015 1020

Pro?Val?Thr?Trp?Ser?Ser?Val?Asp?Val?Ser?Lys?Pro?Gly?Ile?Val?Thr

1025 1030 1035 1040

Val?Lys?Gly?Met?Ala?Asp?Gly?Arg?Glu?Val?Glu?Ala?Arg?Val?Glu?Val

1045 1050 1055

Ile?Ala?Leu?Lys?Ser?Glu?Leu?Pro?Val?Val?Lys?ArgIle?Ala?Pro?Asn

1060 1065 1070

Thr?Asp?Leu?Asn?Ser?Val?Asp?Lys?Ser?Val?Ser?Tyr?Val?Leu?Ile?Asp

1075 1080 1085

Gly?Ser?Val?Glu?Glu?Tyr?Glu?Val?Asp?Lys?Trp?Glu?Ile?Ala?Glu?Glu

1090 1095 1100

Asp?Lys?Ala?Lys?Leu?Ala?Ile?Pro?Gly?Ser?Arg?Ile?Gln?Ala?Thr?Gly

1105 1110 1115 1120

Tyr?Leu?Glu?Gly?Gln?Pro?Ile?His?Ala?Thr?Leu?Val?Val?Glu?Glu?Gly

1125 1130 1135

Asn?Pro?Ala?Ala?Pro?Ala?Val?Pro?Thr?Val?Thr?Val?Gly?Gly?Glu?Ala

1140 1145 1150

Val?Thr?Gly?Leu?Thr?Ser?Gln?Lys?Pro?Met?Gln?Tyr?Arg?Thr?Leu?Ala

1155 1160 1165

Tyr?Gly?Ala?Lys?Leu?Pro?Glu?Val?Thr?Ala?Ser?Ala?Lys?Asn?Ala?Ala

1170 1175 1180

Val?Thr?Val?Leu?Gln?Ala?Ser?Ala?Ala?Asn?Gly?Met?Arg?Ala?Ser?Ile

1185 1190 1195 1200

Phe?Ile?Gln?Pro?Lys?Asp?Gly?Gly?Pro?Leu?Gln?Thr?Tyr?Ala?Ile?Gln

1205 1210 1215

Phe?Leu?Glu?Glu?Ala?Pro?Lys?Ile?Ala?His?Leu?Ser?Leu?Gln?Val?Glu

1220 1225 1230

Lys?Ala?Asp?Ser?Leu?Lys?Glu?Asp?Gln?Thr?Val?Lys?Leu?Ser?Val?Arg

1235 1240 1245

Ala?His?Tyr?Gln?Asp?Gly?Thr?Gln?Ala?Val?Leu?Pro?Ala?Asp?Lys?Val

1250 1255 1260

Thr?Phe?Ser?Thr?Ser?Gly?Glu?Gly?Glu?Val?Ala?Ile?Arg?Lys?Gly?Met

1265 1270 1275 1280

Leu?Glu?Leu?His?Lys?Pro?Gly?Ala?Val?Thr?Leu?Asn?Ala?Glu?Tyr?Glu

1285 1290 1295

Gly?Ala?Lys?Asp?Gln?Val?Glu?Leu?Thr?Ile?Gln?Ala?Asn?Thr?Glu?Lys

1300 1305 1310

Lys?Ile?Ala?Gln?Ser?Ile?Arg?Pro?Val?Asn?Val?Val?Thr?Asp?Leu?His

1315 1320 1325

Gln?Glu?Pro?Ser?Leu?Pro?Ala?Thr?Val?Thr?Val?Glu?Tyr?Asp?Lys?Gly

1330 1335 1340

Phe?Pro?Lys?Thr?His?Lys?Val?Thr?Trp?Gln?Ala?Ile?Pro?Lys?Glu?Lys

1345 1350 1355 1360

Leu?Asp?Ser?Tyr?Gln?Thr?Phe?Glu?Val?Leu?Gly?Lys?Val?Glu?Gly?Ile

1365 1370 1375

Asp?Leu?Glu?Ala?Arg?Ala?Lys?Val?Ser?Val?Glu?Gly?Ile?Val?Ser?Val

1380 1385 1390

Glu?Glu?Val?Ser?Val?Thr?Thr?Pro?Ile?Ala?Glu?Ala?Pro?Gln?Leu?Pro

1395 1400 1405

Glu?Ser?Val?Arg?Thr?Tyr?Asp?Ser?Asn?Gly?His?Val?Ser?Ser?Ala?Lys

1410 1415 1420

Val?Ala?Trp?Asp?Ala?Ile?Arg?Pro?Glu?Gln?Tyr?Ala?Lys?Glu?Gly?Val

1425 1430 1435 1440

Phe?Thr?Val?Asn?Gly?Arg?Leu?Glu?Gly?Thr?Gln?Leu?Thr?Thr?Lys?Leu

1445 1450 1455

His?Val?Arg?Val?Ser?Ala?Gln?Thr?Glu?Gln?Gly?Ala?Asn?Ile?Ser?Asp

1460 1465 1470

Gln?Trp?Thr?Gly?Ser?Glu?Leu?Pro?Leu?Ala?Phe?Ala?Ser?Asp?Ser?Asn

1475 1480 1485

Pro?Ser?Asp?Pro?Val?Ser?Asn?Val?Asn?Asp?Lys?Leu?Ile?Ser?Tyr?Asn

1490 1495 1500

Asn?Gln?Pro?Ala?Asn?Arg?Trp?Thr?Asn?Trp?Asn?Arg?Thr?Asn?Pro?Glu

1505 1510 1515 1520

Ala?Ser?Val?Gly?Val?Leu?Phe?Gly?Asp?Ser?GlyIle?Leu?Ser?Lys?Arg

1525 1530 1535

Ser?Val?Asp?Asn?Leu?Ser?Val?Gly?Phe?His?Glu?Asp?His?Gly?Val?Gly

1540 1545 1550

Val?Pro?Lys?Ser?Tyr?Val?Ile?Glu?Tyr?Tyr?Val?Gly?Lys?Thr?Val?Pro

1555 1560 1565

Thr?Ala?Pro?Lys?Asn?Pro?Ser?Phe?Val?Gly?Asn?Glu?Asp?His?Val?Phe

1570 1575 1580

Asn?Asp?Ser?Ala?Asn?Trp?Lys?Pro?Val?Thr?Asn?Leu?Lys?Ala?Pro?Ala

1585 1590 1595 1600

Gln?Leu?Lys?Ala?Gly?Glu?Met?Asn?His?Phe?Ser?Phe?Asp?Lys?Val?Glu

1605 1610 1615

Thr?Tyr?Ala?Val?Arg?Ile?Arg?Met?Val?Lys?Ala?Asp?Asn?Lys?Arg?Gly

1620 1625 1630

Thr?Ser?Ile?Thr?Glu?Val?Gln?Ile?Phe?Ala?Lys?Gln?Val?Ala?Ala?Ala

1635 1640 1645

Lys?Gln?Gly?Gln?Thr?Arg?Ile?Gln?Val?Asp?Gly?Lys?Asp?Leu?Ala?Asn

1650 1655 1660

Phe?Asn?Pro?Asp?Leu?Thr?Asp?Tyr?Tyr?Leu?Glu?Ser?Val?Asp?Gly?Lys

1665 1670 1675 1680

Val?Pro?Ala?Val?Thr?Ala?Ser?Val?Ser?Asn?Asn?Gly?Leu?Ala?Thr?Val

1685 1690 1695

Val?Pro?Ser?Val?Arg?Glu?Gly?Glu?Pro?Val?Arg?Val?Ile?Ala?Lys?Ala

1700 1705 1710

Glu?Asn?Gly?Asp?Ile?Leu?Gly?Glu?Tyr?Arg?Leu?His?Phe?Thr?Lys?Asp

1715 1720 1725

Lys?Ser?Leu?Leu?Ser?His?Lys?Pro?Val?Ala?Ala?Val?Lys?Gln?Ala?Arg

1730 1735 1740

Leu?Leu?Gln?Val?Gly?Gln?Ala?Leu?Glu?Leu?Pro?Thr?Lys?Val?Pro?Val

1745 1750 1755 1760

Tyr?Phe?Thr?Gly?Lys?Asp?Gly?Tyr?Glu?Thr?Lys?Asp?Leu?Thr?Val?Glu

1765 1770 1775

Trp?Glu?Glu?Val?Pro?Ala?Glu?Asn?Leu?Thr?Lys?Ala?Gly?Gln?Phe?Thr

1780 1785 1790

Val?Arg?Gly?Arg?Val?Leu?Gly?Ser?Asn?Leu?Val?Ala?Glu?Ile?Thr?Val

1795 1800 1805

Arg?Val?Thr?Asp?Lys?Leu?Gly?Glu?Thr?Leu?Ser?Asp?Asn?Pro?Asn?Tyr

1810 1815 1820

Asp?Glu?Asn?Ser?Asn?Gln?Ala?Phe?Ala?Ser?Ala?Thr?Asn?AspIle?Asp

1825 1830 1835 1840

Lys?Asn?Ser?His?Asp?Arg?Val?Asp?Tyr?Leu?Asn?Asp?Gly?Asp?His?Ser

1845 1850 1855

Glu?Asn?Arg?Arg?Trp?Thr?Asn?Trp?Ser?Pro?Thr?Pro?Ser?Ser?Asn?Pro

1860 1865 1870

Glu?Val?Ser?Ala?Gly?Val?Ile?Phe?Arg?Glu?Asn?Gly?Lys?Ile?Val?Glu

1875 1880 1885

Arg?Thr?Val?Thr?Gln?Gly?Lys?Val?Gln?Phe?Phe?Ala?Asp?Ser?Gly?Thr

1890 1895 1900

Asp?Ala?Pro?Ser?Lys?Leu?Val?Leu?Glu?Arg?Tyr?Val?Gly?Pro?Glu?Phe

1905 1910 1915 1920

Glu?Val?Pro?Thr?Tyr?Tyr?Ser?Asn?Tyr?Gln?Ala?Tyr?Asp?Ala?Asp?His

1925 1930 1935

Pro?Phe?Asn?Asn?Pro?Glu?Asn?Trp?Glu?Ala?Val?Pro?Tyr?Arg?Ala?Asp

1940 1945 1950

Lys?Asp?Ile?Ala?Ala?Gly?Asp?Glu?Ile?Asn?Val?Thr?Phe?Lys?Ala?Ile

1955 1960 1965

Lys?Ala?Lys?Ala?Met?Arg?Trp?Arg?Met?Glu?Arg?Lys?Ala?Asp?Lys?Ser

1970 1975 1980

Gly?Val?Ala?Met?Ile?Glu?Met?Thr?Phe?Leu?Ala?Pro?Ser?Glu?Leu?Pro

1985 1990 1995 2000

Gln?Glu?Ser?Thr?Gln?Ser?Lys?Ile?Leu?Val?Asp?Gly?Lys?Glu?Leu?Ala

2005 2010 2015

Asp?Phe?Ala?Glu?Asn?Arg?Gln?Asp?Tyr?Gln?Ile?Thr?Tyr?Lys?Gly?Gln

2020 2025 2030

Arg?Pro?Lys?Val?Ser?Val?Glu?Glu?Asn?Asn?Gln?Val?Ala?Ser?Thr?Val

2035 2040 2045

Val?Asp?Ser?Gly?Glu?Asp?Ser?Phe?Pro?Val?Leu?Val?Arg?Leu?Val?Ser

2050 2055 2060

Glu?Ser?Gly?Lys?Gln?Val?Lys?Glu?Tyr?Arg?Ile?His?Leu?Thr?Lys?Glu

2065 2070 2075 2080

Lys?Pro?Val?Ser?Glu?Lys?Thr?Val?Ala?Ala?Val?Gln?Glu?Asp?Leu?Pro

2085 2090 2095

Lys?lle?Glu?Phe?Val?Glu?Lys?Asp?Leu?Ala?Tyr?Lys?Thr?Val?Glu?Lys

2100 2105 2110

Lys?Asp?Ser?Thr?Leu?Tyr?Leu?Gly?Glu?Thr?Arg?Val?Glu?Gln?Glu?Gly

2115 2120 2125

Lys?Val?Gly?Lys?Glu?Arg?Ile?Phe?Thr?Ala?Ile?Asn?Pro?Asp?Gly?Ser

2130 2135 2140

Lys?Glu?Glu?Lys?Leu?Arg?Glu?Val?Val?Glu?Val?Pro?Thr?Asp?Arg?Ile

2145 2150 2155 2160

Val?Leu?Val?Gly?Thr?Lys?Pro?Val?Ala?Gln?Glu?Ala?Lys?Lys?Pro?Gln

2165 2170 2175

Val?Ser?Glu?Lys?Ala?Asp?Thr?Lys?Pro?Ile?Asp?Ser?Ser?Glu?Ala?Ser

2180 2185 2190

Gln?Thr?Asn?Lys?Ala?Gln?Leu?Pro?Ser?Thr?Gly?Ser?Ala?Ala?Ser?Gln

2195 2200 2205

Ala?Ala?Val?Ala?Ala?Gly?Leu?Thr?Leu?Leu?Gly?Leu?Ser?Ala?Gly?Leu

2210 2215 2220

Val?Val?Thr?Lys?Gly?Lys?Lys?Glu?Asp

2225 2230

<210>3

<211>470

<212>PRT

＜213〉streptococcus pneumoniae

<400>3

Met?Lys?Ile?Met?Lys?Lys?Lys?Tyr?Trp?Thr?Leu?Ala?Ile?Leu?Phe?Phe

1 5 10 15

Cys?Leu?Phe?Asn?Asn?Ser?Val?Thr?Ala?Gln?Glu?Ile?Pro?Lys?Asn?Leu

20 25 30

Asp?Gly?Asn?Ile?Thr?His?Thr?Gln?Thr?Ser?Glu?Ser?Phe?Ser?Glu?Ser

35 40 45

Asp?Glu?Lys?Gln?Val?Asp?Tyr?Ser?Asn?Lys?Asn?Gln?Glu?Glu?Val?Asp

50 55 60

Gln?Asn?Lys?Phe?Arg?Ile?Gln?Ile?Asp?Lys?Thr?Glu?Leu?Phe?Val?Thr

65 70 75 80

Thr?Asp?Lys?His?Leu?Glu?Lys?Asn?Cys?Cys?Lys?Leu?Glu?Leu?Glu?Pro

85 90 95

Gln?Ile?Asn?Asn?Asp?Ile?Val?Asn?Ser?Glu?Ser?Asn?Asn?Leu?Leu?Gly

100 105 110

Glu?Asp?Asn?Leu?Asp?Asn?Lys?Ile?Lys?Glu?Asn?Val?Ser?His?Leu?Asp

115 120 125

Asn?Arg?Gly?Gly?Asn?Ile?Glu?His?Asp?Lys?Asp?Asn?Leu?Glu?Ser?Ser

130 135 140

Ile?Val?Arg?Lys?Tyr?Glu?Trp?Asp?Ile?Asp?Lys?Val?Thr?Gly?Gly?Gly

145 150 155 160

Glu?Ser?Tyr?Lys?Leu?Tyr?Ser?Lys?Ser?Asn?Ser?Lys?Val?Ser?Ile?Ala

165 170 175

Ile?Leu?Asp?Ser?Gly?Val?Asp?Leu?Gln?Asn?Thr?Gly?Leu?Leu?Lys?Asn

180 185 190

Leu?Ser?Asn?His?Ser?Lys?Asn?Tyr?Val?Pro?Asn?Lys?Gly?Tyr?Leu?Gly

195 200 205

Lys?Glu?Glu?Gly?Glu?Glu?Gly?Ile?Ile?Ser?Asp?Ile?Gln?Asp?Arg?Leu

210 215 220

Gly?His?Gly?Thr?Ala?Val?Val?Ala?Gln?Ile?Val?Gly?Asp?Asp?Asn?Ile

225 230 235 240

Asn?Gly?Val?Asn?Pro?His?Val?Asn?Ile?Asn?Val?Tyr?Arg?Ile?Phe?Gly

245 250 255

Lys?Ser?Ser?Ala?Ser?Pro?Asp?Trp?Ile?Val?Lys?Ala?Ile?Phe?Asp?Ala

260 265 270

Val?Asp?Asp?Gly?Asn?Asp?Ile?Ile?Asn?Leu?Ser?Thr?Gly?Gln?Tyr?Leu

275 280 285

Met?Ile?Asp?Gly?Glu?Tyr?Glu?Asp?Gly?Thr?Asn?Asp?Phe?Glu?Thr?Phe

290 295 300

Leu?Lys?Tyr?Lys?Lys?Ala?Ile?Asp?Tyr?Ala?Asn?Gln?Lys?Gly?Val?Ile

305 310 315 320

Ile?Val?Ala?Ala?Leu?Gly?Asn?Asp?Ser?Leu?Asn?Val?Ser?Asn?Gln?Ser

325 330 335

Asp?Leu?Leu?Lys?Leu?Ile?Ser?Ser?Arg?Lys?Lys?Val?Arg?Lys?Pro?Gly

340 345 350

Leu?Val?Val?Asp?Val?Pro?Ser?Tyr?Phe?Ser?Ser?Thr?Ile?Ser?Val?Gly

355 360 365

Gly?Ile?Asp?Arg?Leu?Gly?Asn?Leu?Ser?Asp?Phe?Ser?Asn?Lys?Gly?Asp

370 375 380

Ser?Asp?Ala?Ile?Tyr?Ala?Pro?Ala?Gly?Ser?Thr?Leu?Ser?Leu?Ser?Glu

385 390 395 400

Leu?Gly?Leu?Asn?Asn?Phe?Ile?Asn?Ala?Glu?Lys?Tyr?Lys?Glu?Asp?Trp

405 410 415

Ile?Phe?Ser?Ala?Thr?Leu?Gly?Gly?Tyr?Thr?Tyr?Leu?Tyr?Gly?Asn?Ser

420 425 430

Phe?Ala?Ala?Pro?Lys?Val?Ser?Gly?Ala?Ile?Ala?Met?Ile?Ile?Asp?Lys

435 440 445

Tyr?Lys?Leu?Lys?Asp?Gln?Pro?Tyr?Asn?Tyr?Met?Phe?Val?Lys?Lys?Phe

450 455 460

Trp?Lys?Lys?His?Tyr?Gln

465 470

<210>4

<211>335

<212>PRT

＜213〉streptococcus pneumoniae

<400>4

Met?Lys?Lys?Thr?Trp?Lys?Val?Phe?Leu?Thr?Leu?Val?Thr?Ala?Leu?Val

1 5 10 15

Ala?Val?Val?Leu?Val?Ala?Cys?Gly?Gln?Gly?Thr?Ala?Ser?Lys?Asp?Asn

20 25 30

Lys?Glu?Ala?Glu?Leu?Lys?Lys?Val?Asp?Phe?Ile?Leu?Asp?Trp?Thr?Pro

35 40 45

Asn?Thr?Asn?His?Thr?Gly?Leu?Tyr?Val?Ala?Lys?Glu?Lys?Gly?Tyr?Phe

50 55 60

Lys?Glu?Ala?Gly?Val?Asp?Val?Asp?Leu?Lys?Leu?Pro?Pro?Glu?Glu?Ser

65 70 75 80

Ser?Ser?Asp?Leu?Val?Ile?Asn?Gly?Lys?Ala?Pro?Phe?Ala?Val?Tyr?Phe

85 90 95

Gln?Asp?Tyr?Met?Ala?Lys?Lys?Leu?Glu?Lys?Gly?Ala?Gly?Ile?Thr?Ala

100 105 110

ValAla?Ala?Ile?Val?Glu?His?Asn?Thr?Ser?Gly?Ile?Ile?Ser?Arg?Lys

115 120 125

Ser?Asp?Asn?Val?Ser?Ser?Pro?Lys?Asp?Leu?Val?Gly?Lys?Lys?Tyr?Gly

130 135 140

Thr?Trp?Asn?Asp?Pro?Thr?Glu?Leu?Ala?Met?Leu?Lys?Thr?Leu?Val?Glu

145 150 155 160

Ser?Gln?Gly?Gly?Asp?Phe?Glu?Lys?Val?Glu?Lys?Val?Pro?Asn?Asn?Asp

165 170 175

Ser?Asn?Ser?Ile?Thr?Pro?Ile?Ala?Asn?Gly?Val?Phe?Asp?Thr?Ala?Trp

180 185 190

Ile?Tyr?Tyr?Gly?Trp?Asp?Gly?Ile?Leu?Ala?Lys?Ser?Gln?Gly?Val?Asp

195 200 205

Ala?Asn?Phe?Met?Tyr?Leu?Lys?Asp?Tyr?Val?Lys?Glu?Phe?Asp?Tyr?Tyr

210 215 220

Ser?Pro?Val?Ile?Ile?Ala?Asn?Asn?Asp?Tyr?Leu?Lys?Asp?Asn?Lys?Glu

225 230 235 240

Glu?Ala?Arg?Lys?Val?Ile?Gln?Ala?Ile?Lys?Lys?Gly?Tyr?Gln?Tyr?Ala

245 250 255

Met?Glu?His?Pro?Glu?Glu?Ala?Ala?Asp?Ile?Leu?Ile?Lys?Asn?Ala?Pro

260 265 270

Glu?Leu?Lys?Glu?Lys?Arg?Asp?Phe?Val?Ile?Glu?Ser?Gln?Lys?Tyr?Leu

275 280 285

Ser?Lys?Glu?Tyr?Ala?Ser?Asp?Lys?Glu?Lys?Trp?Gly?Gln?Phe?Asp?Ala

290 295 300

Ala?Arg?Trp?Asn?Ala?Phe?Tyr?Lys?Trp?Asp?Lys?Glu?Asn?Gly?Ile?Leu

305 310 315 320

Lys?Glu?Asp?Leu?Thr?Asp?Lys?Gly?Phe?Thr?Asn?Glu?Phe?Val?Lys

325 330 335

<210>5

<211>335

<212>PRT

＜213〉streptococcus pneumoniae

<400>5

Met?Lys?Arg?Thr?Trp?Arg?Asn?Ser?Phe?Val?Thr?Asn?Leu?Asn?Thr?Pro

1 5 10 15

Phe?Met?Ile?Gly?Asn?Ile?Glu?Ile?Pro?Asn?Arg?Thr?Val?Leu?Ala?Pro

20 25 30

Met?Ala?Gly?Val?Thr?Asn?Ser?Ala?Phe?Arg?Thr?Ile?Ala?Lys?Glu?Leu

35 40 45

Gly?Ala?Gly?Leu?Val?Val?Met?Glu?Met?Val?Ser?Asp?Lys?Gly?Ile?Gln

50 55 60

Tyr?Asn?Asn?Glu?Lys?Thr?Leu?His?Met?Leu?His?Ile?Asp?Glu?Gly?Glu

65 70 75 80

Asn?Pro?Val?Ser?Ile?Gln?Leu?Phe?Gly?Ser?Asp?Glu?Asp?Ser?Leu?Ala

85 90 95

Arg?Ala?Ala?Glu?Phe?Ile?Gln?Glu?Asn?Thr?Lys?Thr?Asp?Ile?Val?Asp

100 105 110

Ile?Asn?Met?Gly?Cys?Pro?Val?Asn?Lys?Ile?Val?Lys?Asn?Glu?Ala?Gly

115 120 125

Ala?Met?Trp?Leu?Lys?Asp?Pro?Asp?Lys?Ile?Tyr?Ser?Ile?Ile?Asn?Lys

130 135 140

Val?Gln?Ser?Val?Leu?Asp?Ile?Pro?Leu?Thr?Val?Lys?Met?Arg?Thr?Gly

145 150 155 160

Trp?Ala?Asp?Pro?Ser?Leu?Ala?Val?Glu?Asn?Ala?Leu?Ala?Ala?Glu?Ala

165 170 175

Ala?Gly?Val?Ser?Ala?Leu?Ala?Met?His?Gly?Arg?Thr?Arg?Glu?Gln?Met

180 185 190

Tyr?Thr?Gly?His?Ala?Asp?Leu?Glu?Thr?Leu?Tyr?Lys?Val?Ala?Gln?Ala

195 200 205

Leu?Thr?Lys?Ile?Pro?Phe?Ile?Ala?Asn?Gly?Asp?Ile?Arg?Thr?Val?Gln

210 215 220

Glu?Ala?Lys?Gln?Arg?Ile?Glu?Glu?Val?Gly?Ala?Asp?Ala?Val?Met?Ile

225 230 235 240

Gly?Arg?Ala?Ala?Met?Gly?Asn?Pro?Tyr?Leu?Phe?Asn?Gln?Ile?Asn?His

245 250 255

Tyr?Phe?Glu?Thr?Gly?Glu?Ile?Leu?Pro?Asp?Leu?Thr?Phe?Glu?Asp?Lys

260 265 270

Met?Lys?Ile?Ala?Tyr?Glu?His?Leu?Lys?Arg?Leu?Ile?Asn?Leu?Lys?Gly

275 280 285

Glu?Asn?Val?Ala?Val?Arg?Glu?Phe?Arg?Gly?Leu?Ala?Pro?His?Tyr?Leu

290 295 300

Arg?Gly?Thr?Ser?Gly?Ala?Ala?Lys?Leu?Arg?Gly?Ala?Ile?Ser?Gln?Ala

305 310 315 320

Ser?Thr?Leu?Ala?Glu?Ile?Glu?Thr?Leu?Leu?Gln?Leu?Glu?Lys?Ala

325 330 335

<210>6

<211>442

<212>PRT

＜213〉streptococcus pneumoniae

<400>6

Met?Ile?Lys?Asn?Pro?Lys?Leu?Leu?Thr?Lys?Ser?Phe?Leu?Arg?Ser?Phe

1 5 10 15

Ala?Ile?Leu?Gly?Gly?Val?Gly?Leu?Val?Ile?His?Ile?Ala?Ile?Tyr?Leu

20 25 30

Thr?Phe?Pro?Phe?Tyr?Tyr?Ile?Gln?Leu?Glu?Gly?Glu?Lys?Phe?Asn?Glu

35 40 45

Ser?Ala?Arg?Val?Phe?Thr?Glu?Tyr?Leu?Lys?Thr?Lys?Thr?Ser?Asp?Glu

50 55 60

Ile?Pro?Ser?Leu?Leu?Gln?Ser?Tyr?Ser?Lys?Ser?Leu?Thr?Ile?Ser?Ala

65 70 75 80

His?Leu?Lys?Arg?Asp?Ile?Val?Asp?Lys?Arg?Leu?Pro?Leu?Val?His?Asp

85 90 95

Leu?Asp?Ile?Lys?Asp?Gly?Lys?Leu?Ser?Asn?Tyr?Ile?Val?Met?Leu?Asp

100 105 110

Met?Ser?Val?Ser?Thr?Ala?Asp?Gly?Lys?Gln?Val?Thr?Val?Gln?Phe?Val

115 120 125

His?Gly?Val?Asp?Val?Tyr?Lys?Glu?Ala?Lys?Asn?Ile?Leu?Leu?Leu?Tyr

130 135 140

Leu?Pro?Tyr?Thr?Phe?Leu?Val?Thr?Ile?Ala?Phe?Ser?Phe?Val?Phe?Ser

145 150 155 160

Tyr?Phe?Tyr?Thr?Lys?Arg?Leu?Leu?Asn?Pro?Leu?Phe?Tyr?Ile?Ser?Glu

165 170 175

Val?Thr?Ser?Lys?Met?Gln?Asp?Leu?Asp?Asp?Asn?Ile?Arg?Phe?Asp?Glu

180 185 190

Ser?Arg?Lys?Asp?Glu?Val?Gly?Glu?Val?Gly?Lys?Gln?Ile?Asn?Gly?Met

195 200 205

Tyr?Glu?His?Leu?Leu?Lys?Val?Ile?Tyr?Glu?Leu?Glu?Ser?Arg?Asn?Glu

210 215 220

Gln?Ile?Val?Lys?Leu?Gln?Asn?Gln?Lys?Val?Ser?Phe?Val?Arg?Gly?Ala

225 230 235 240

Ser?His?Glu?Leu?Lys?Thr?Pro?Leu?Ala?Ser?Leu?Arg?Ile?Ile?Leu?Glu

245 250 255

Asn?Met?Gln?His?Asn?Ile?Gly?Asp?Tyr?Lys?Asp?His?Pro?Lys?Tyr?Ile

260 265 270

Ala?Lys?Ser?Ile?Asn?Lys?Ile?Asp?Gln?Met?Ser?His?Leu?Leu?Glu?Glu

275 280 285

Val?Leu?Glu?Ser?Ser?Lys?Phe?Gln?Glu?Trp?Thr?Glu?Cys?Arg?Glu?Thr

290 295 300

Thr?Val?Lys?Pro?Val?Leu?Val?Asp?Ile?Leu?Ser?Arg?Tyr?Gln?Glu?Leu

305 310 315 320

Ala?His?Ser?Ile?Gly?Val?Thr?Ile?Glu?Asn?Gln?Leu?Thr?Asp?Ala?Thr

325 330 335

Arg?Val?Val?Met?Ser?Leu?Arg?Ala?Leu?Asp?Lys?Val?Leu?Thr?Asn?Leu

340 345 350

Ile?Ser?Asn?Ala?Ile?Lys?Tyr?Ser?Asp?Lys?Asn?Gly?Arg?Val?Ile?Ile

355 360 365

Ser?Glu?Gln?Asp?Gly?Tyr?Leu?Ser?Ile?Lys?Asn?Thr?Cys?Ala?Pro?Leu

370 375 380

Ser?Asp?Gln?Glu?Leu?Glu?His?Leu?Phe?Asp?Ile?Phe?Tyr?His?Ser?Gln

385 390 395 400

Ile?Val?Thr?Asp?Lys?Asp?Glu?Ser?Ser?Gly?Leu?Gly?Leu?Tyr?Ile?Val

405 410 415

Asn?Asn?Ile?Leu?Glu?Ser?Tyr?Gln?Met?Asp?Tyr?Ser?Phe?Leu?Pro?Tyr

420 425 430

Glu?His?Gly?Met?Glu?Phe?Lys?Ile?Ser?Leu

435 440

<210>7

<211>475

<212>PRT

＜213〉streptococcus pneumoniae

<400>7

Met?Tyr?Leu?Gly?Asp?Leu?Met?Glu?Lys?Ala?Glu?Cys?Gly?Gln?Phe?Ser

1 5 10 15

Ile?Leu?Ser?Phe?Leu?Leu?Gln?Glu?Ser?Gln?Thr?Thr?Val?Lys?Ala?Val

20 25 30

Met?Glu?Glu?Thr?Gly?Phe?Ser?Lys?Ala?Thr?Leu?Thr?Lys?Tyr?Val?Thr

35 40 45

Leu?Leu?Asn?Asp?Lys?Ala?Leu?Asp?Ser?Gly?Leu?Glu?Leu?Ala?Ile?His

50 55 60

Ser?Glu?Asp?Glu?Asn?Leu?Arg?Leu?Ser?Ile?Gly?Ala?Ala?Thr?Lys?Gly

65 70 75 80

Arg?Asp?Ile?Arg?Ser?Leu?Phe?Leu?Glu?Ser?Ala?Val?Lys?Tyr?Gln?Ile

85 90 95

Leu?Val?Tyr?Leu?Leu?Tyr?His?Gln?Gln?Phe?Leu?Ala?His?Gln?Leu?Ala

100 105 110

Gln?Glu?Leu?Val?Ile?Ser?Glu?Ala?Thr?Leu?Gly?Arg?His?Leu?Ala?Gly

115 120 125

Leu?Asn?Gln?Ile?Leu?Ser?Glu?Phe?Asp?Leu?Ser?Ile?Gln?Asn?Gly?Arg

130 135 140

Trp?Arg?Gly?Pro?Glu?His?Gln?Ile?His?Tyr?Phe?Tyr?Phe?Cys?Leu?Phe

145 150 155 160

Arg?Lys?Val?Trp?Ser?Ser?Gln?Glu?Trp?Glu?Gly?His?Met?Gln?Lys?Pro

165 170 175

Glu?Arg?Lys?Gln?Glu?Ile?Ala?Asn?Leu?Glu?Glu?Ile?Cys?Gly?Ala?Ser

180 185 190

Leu?Ser?Ala?Gly?Gln?Lys?Leu?Asp?Leu?Val?Leu?Trp?Ala?His?Ile?Ser

195 200 205

Gln?Gln?Arg?Leu?Arg?Val?Asn?Ala?Cys?Gln?Phe?Gln?Val?Ile?Glu?Glu

210 215 220

Lys?Met?Arg?Gly?Tyr?Phe?Asp?Asn?Ile?Phe?Tyr?Leu?Arg?Leu?Leu?Arg

225 230 235 240

Lys?Val?Pro?Ser?Phe?Phe?Ala?Gly?Gln?His?Ile?Pro?Leu?Gly?Val?Glu

245 250 255

Asp?Gly?Glu?Met?Met?Ile?Phe?Phe?Ser?Phe?Leu?Leu?Ser?His?Arg?Ile

260 265 270

Leu?Pro?Leu?His?Thr?Met?Glu?Tyr?Ile?Leu?Gly?Phe?Gly?Gly?Gln?Leu

275 280 285

Ala?Asp?Leu?Leu?Thr?Gln?Leu?Ile?Gln?Glu?Met?Lys?Lys?Glu?Glu?Leu

290 295 300

Leu?Gly?Asp?Tyr?Thr?Glu?Asp?His?Val?Thr?Tyr?Glu?Leu?Ser?Gln?Leu

305 310 315 320

Cys?Ala?Gln?Val?Tyr?Leu?Tyr?Lys?Gly?Tyr?Ile?Leu?Gln?Asp?Arg?Tyr

325 330 335

Lys?Tyr?Gln?Leu?Glu?Asn?Arg?His?Pro?Tyr?Leu?Leu?Met?Glu?His?Asp

340 345 350

Phe?Lys?Glu?Thr?Ala?Glu?Glu?Ile?Phe?His?Ala?Leu?Pro?Ala?Phe?Gln

355 360 365

Gln?Gly?Thr?Asp?Leu?Asp?Lys?Lys?Ile?Leu?Trp?Glu?Trp?Leu?Gln?Leu

370 375 380

Ile?Glu?Tyr?Met?Ala?Glu?Asn?Gly?Gly?Gln?His?Met?Arg?Ile?Gly?Leu

385 390 395 400

Asp?Leu?Thr?Ser?Gly?Phe?Leu?Val?Phe?Ser?Arg?Met?Ala?Ala?Ile?Leu

405 410 415

Lys?Arg?Tyr?Leu?Glu?Tyr?Asn?Arg?Phe?Ile?Thr?Ile?Glu?Ala?Tyr?Asp

420 425 430

Pro?Ser?Arg?His?Tyr?Asp?Leu?Leu?Val?Thr?Asn?Asn?Pro?Ile?His?Lys

435 440 445

Lys?Glu?Gln?Thr?Pro?Val?Tyr?Tyr?Leu?Lys?Asn?Asp?Leu?Asp?Met?Glu

450 455 460

Asp?Leu?Val?Ala?Ile?Arg?Gln?Leu?Leu?Phe?Thr

465 470 475

<210>8

<211>608

<212>PRT

＜213〉streptococcus pneumoniae

<400>8

Met?Glu?Phe?Ser?Lys?Lys?Thr?Arg?Glu?Leu?Ser?Ile?Lys?Lys?Met?Gln

1 5 10 15

Glu?Arg?Thr?Leu?Asp?Leu?Leu?Ile?Ile?Gly?Gly?Gly?Ile?Thr?Gly?Ala

20 25 30

Gly?Val?Ala?Leu?Gln?Ala?Ala?Ala?Ser?Gly?Leu?Glu?Thr?Gly?Leu?Ile

35 40 45

Glu?Met?Gln?Asp?Phe?Ala?Glu?Gly?Thr?Ser?Ser?Arg?Ser?Thr?Lys?Leu

50 55 60

Val?His?Gly?Gly?Leu?Arg?Tyr?Leu?Lys?Gln?Phe?Asp?Val?Glu?Val?Val

65 70 75 80

Ser?Asp?Thr?Val?Ser?Glu?Arg?Ala?Val?Val?Gln?Gln?Ile?Ala?Pro?His

85 90 95

Ile?Pro?Lys?Ser?Asp?Pro?Met?Leu?Leu?Pro?Val?Tyr?Asp?Glu?Asp?Gly

100 105 110

Ala?Thr?Phe?Ser?Leu?Phe?Arg?Leu?Lys?Val?Ala?Met?Asp?Leu?Tyr?Asp

115 120 125

Leu?Leu?Ala?Gly?Val?Ser?Asn?Thr?Pro?Ala?Ala?Asn?Lys?Val?Leu?Ser

130 135 140

Lys?Asp?Gln?Val?Leu?Glu?Arg?Gln?Pro?Asn?Leu?Lys?Lys?Glu?Gly?Leu

145 150 155 160

Val?Gly?Gly?Gly?Val?Tyr?Leu?Asp?Phe?Arg?Asn?Asn?Asp?Ala?Arg?Leu

165 170 175

Val?Ile?Glu?Asn?Ile?Lys?Arg?Ala?Asn?Gln?Asp?Gly?Ala?Leu?Ile?Ala

180 185 190

Asn?His?Val?Lys?Ala?Glu?Gly?Phe?Leu?Phe?Asp?Glu?Ser?Gly?Lys?Ile

195 200 205

Thr?Gly?Val?Val?Ala?Arg?Asp?Leu?Leu?Thr?Asp?Gln?Val?Phe?Glu?Ile

210 215 220

Lys?Ala?Arg?Leu?Val?Ile?Asn?Thr?Thr?Gly?Pro?Trp?Ser?Asp?Lys?Val

225 230 235 240

Arg?Asn?Leu?Ser?Asn?Lys?Gly?Thr?Gln?Phe?Ser?Gln?Met?Arg?Pro?Thr

245 250 255

Lys?Gly?Val?His?Leu?Val?Val?Asp?Ser?Ser?Lys?Ile?Lys?Val?Ser?Gln

260 265 270

Pro?Val?Tyr?Phe?Asp?Thr?Gly?Leu?Gly?Asp?Gly?Arg?Met?Val?Phe?Val

275 280 285

Leu?Pro?Arg?Glu?Asn?Lys?Thr?Tyr?Phe?Gly?Thr?Thr?Asp?Thr?Asp?Tyr

290 295 300

Thr?Gly?Asp?Leu?Glu?His?Pro?Lys?Val?Thr?Gln?Glu?Asp?Val?Asp?Tyr

305 310 315 320

Leu?Leu?Gly?Ile?Val?Asn?Asn?Arg?Phe?Pro?Glu?Ser?Asn?Ile?Thr?Ile

325 330 335

Asp?Asp?Ile?Glu?Ser?Ser?Trp?Ala?Gly?Leu?Arg?Pro?Leu?Ile?Ala?Gly

340 345 350

Asn?Ser?Ala?Ser?Asp?Tyr?Asn?Gly?Gly?Asn?Asn?Gly?Thr?Ile?Ser?Asp

355 360 365

Glu?Ser?Phe?Asp?Asn?Leu?Ile?Ala?Thr?Val?Glu?Ser?Tyr?Leu?Ser?Lys

370 375 380

Glu?Lys?Thr?Arg?Glu?Asp?Val?Glu?Ser?Ala?Val?Ser?Lys?Leu?Glu?Ser

385 390 395 400

Ser?Thr?Ser?Glu?Lys?His?Leu?Asp?Pro?Ser?Ala?Val?Ser?Arg?Gly?Ser

405 410 415

Ser?Leu?Asp?Arg?Asp?Asp?Asn?Gly?Leu?Leu?Thr?Leu?Ala?Gly?Gly?Lys

420 425 430

Ile?Thr?Asp?Tyr?Arg?Lys?Met?Ala?Glu?Gly?Ala?Met?Glu?Arg?Val?Val

435 440 445

Asp?Ile?Leu?Lys?Ala?Glu?Phe?Asp?Arg?Ser?Phe?Lys?Leu?Ile?Asn?Ser

450 455 460

Lys?Thr?Tyr?Pro?Val?Ser?Gly?Gly?Glu?Leu?Asn?Pro?Ala?Asn?Val?Asp

465 470 475 480

Ser?Glu?Ile?Glu?Ala?Phe?Ala?Gln?Leu?Gly?Val?Ser?Arg?Gly?Leu?Asp

485 490 495

Ser?Lys?Glu?Ala?His?Tyr?Leu?Ala?Asn?Leu?Tyr?Gly?Ser?Asn?Ala?Pro

500 505 510

Lys?Val?Phe?Ala?Leu?Ala?His?Ser?Leu?Glu?Gln?Ala?Pro?Gly?Leu?Ser

515 520 525

Leu?Ala?Asp?Thr?Leu?Ser?Leu?His?Tyr?Ala?Met?Arg?Asn?Glu?Leu?Thr

530 535 540

Leu?Ser?Pro?Val?Asp?Phe?Leu?Leu?Arg?Arg?Thr?Asn?His?Met?Leu?Phe

545 550 555 560

Met?Arg?Asp?Ser?Leu?Asp?Ser?Ile?Val?Glu?Pro?Ile?Leu?Asp?Glu?Met

565 570 575

Gly?Arg?Phe?Tyr?Asp?Trp?Thr?Glu?Glu?Glu?Lys?Ala?Thr?Tyr?Arg?Ala

580 585 590

Asp?Val?Glu?Ala?Ala?Leu?Ala?Asn?Asn?Asp?Leu?Ala?Glu?Leu?Lys?Asn

595 600 605

<210>9

<211>234

<212>PRT

＜213〉streptococcus pneumoniae

<400>9

Met?Met?Asn?Glu?Leu?Phe?Gly?Glu?Phe?Leu?Gly?Thr?Leu?Ile?Leu?Ile

1 5 10 15

Leu?Leu?Gly?Asn?Gly?Val?Val?Ala?Gly?Val?Val?Leu?Pro?Lys?Thr?Lys

20 25 30

Ser?Asn?Ser?Ser?Gly?Trp?Ile?Val?Ile?Thr?Met?Gly?Trp?Gly?Ile?Ala

35 40 45

Val?Ala?Val?Ala?Val?Phe?Val?Ser?Gly?Lys?Leu?Ser?Pro?Ala?Tyr?Leu

50 55 60

Asn?Pro?Ala?Val?Thr?Ile?Gly?Val?Ala?Leu?Lys?Gly?Gly?Leu?Pro?Trp

65 70 75 80

Ala?Ser?Val?Leu?Pro?Tyr?Ile?Leu?Ala?Gln?Phe?Ala?Gly?Ala?Met?Leu

85 90 95

Gly?Gln?Ile?Leu?Val?Trp?Leu?Gln?Phe?Lys?Pro?His?Tyr?Glu?Ala?Glu

100 105 110

Glu?Asn?Ala?Gly?Asn?Ile?Leu?Ala?Thr?Phe?Ser?Thr?Gly?Pro?Ala?Ile

115 120 125

Lys?Asp?Thr?Val?Ser?Asn?Leu?Ile?Ser?Glu?Ile?Leu?Gly?Thr?Phe?Val

130 135 140

Leu?Val?Leu?Thr?Ile?Phe?Ala?Leu?Gly?Leu?Tyr?Asp?Phe?Gln?Ala?Gly

145 150 155 160

Ile?Gly?Thr?Phe?Ala?Val?Gly?Thr?Leu?Ile?Val?Gly?Ile?Gly?Leu?Ser

165 170 175

Leu?Gly?Gly?Thr?Thr?Gly?Tyr?Ala?Leu?Asn?Pro?Ala?Arg?Asp?Leu?Gly

180 185 190

Pro?Arg?Ile?Met?His?Ser?Ile?Leu?Pro?Ile?Pro?Asn?Lys?Gly?Asp?Gly

195 200 205

Asp?Trp?Ser?Tyr?Ala?Trp?Ile?Pro?Val?Val?Gly?Pro?Val?Ile?Gly?Ala

210 215 220

Ala?Leu?Ala?Val?Leu?Val?Phe?Ser?Leu?Phe

225 230

<210>10

<211>136

<212>PRT

＜213〉streptococcus pneumoniae

<400>10

Met?Thr?Lys?Lys?Lys?Ile?Glu?Arg?Ile?Ser?Val?Ile?His?Arg?Glu?Lys

1 5 10 15

Ile?Leu?Trp?Leu?Lys?Trp?Tyr?Phe?Met?Arg?Asp?Lys?Glu?Gln?Pro?Lys

20 25 30

Tyr?Ser?Val?Leu?Glu?Arg?Lys?Met?Phe?Asp?Ala?Ala?Lys?Asn?Gln?Asp

35 40 45

Met?Leu?Ala?Tyr?Gln?Lys?Tyr?Ala?Thr?Ile?Lys?Gln?Ile?Thr?Asp?Ile

50 55 60

Arg?Val?Gln?Thr?Ser?Glu?Ala?Asp?Ile?Leu?Glu?Ala?Val?Lys?Glu?Val

65 70 75 80

Tyr?Val?Tyr?Asn?His?Met?Asn?Val?Ile?Gly?Ala?Cys?Gln?Arg?Ile?Leu

85 90 95

Phe?Ile?Ser?Gln?Ser?Pro?Ala?Tyr?Asp?Lys?Leu?Asn?Lys?Trp?Phe?Asn

100 105 110

Ile?Tyr?Ser?Asp?Leu?Tyr?Phe?Ser?Val?Val?Pro?Leu?Pro?Lys?Met?Gly

115 120 125

Val?Tyr?His?Glu?Met?Val?Gly?Ile

130 135

<210>11

<211>1099

<212>PRT

＜213〉streptococcus pneumoniae

<400>11

Met?Lys?Asn?Ser?Asn?Glu?Ala?Glu?Met?Lys?Leu?Leu?Tyr?Thr?Asp?Ile

1 5 10 15

Arg?Thr?Ser?Leu?Thr?Glu?Ile?Leu?Thr?Arg?Glu?Ala?Glu?Glu?Leu?Val

20 25 30

Ala?Ala?Gly?Lys?Arg?Val?Phe?Tyr?Ile?Ala?Pro?Asn?Ser?Leu?Ser?Phe

35 40 45

Glu?Lys?Glu?Arg?Ala?Val?Leu?Glu?Tyr?Leu?Ser?Gln?Gln?Ala?Ser?Phe

50 55 60

Ser?Ile?Thr?Val?Thr?Arg?Phe?Ala?Gln?Met?Ala?Arg?Tyr?Leu?Val?Leu

65 70 75 80

Asn?Asp?Leu?Pro?Ala?Lys?Thr?Thr?Leu?Asp?Asp?Ile?Gly?Leu?Gly?Leu

85 90 95

Ala?Phe?Tyr?Lys?Cys?Leu?Ala?Glu?Leu?Asp?Pro?Lys?Asp?Leu?Arg?Val

100 105 110

Tyr?Gly?Ala?Ile?Lys?Gln?Asp?Pro?Gln?Leu?Ile?Gln?Gln?Leu?Ile?Glu

115 120 125

Leu?Tyr?His?Glu?Met?Thr?Lys?Ser?Gln?Met?Ser?Phe?Leu?Asp?Leu?Glu

130 135 140

Asn?Leu?Thr?Asp?Glu?Asp?Lys?Arg?Ala?Asp?Leu?Leu?Leu?Ile?Phe?Glu

145 150 155 160

Lys?Val?Thr?Ala?Tyr?Leu?Asn?Gln?Gly?Gln?Leu?Ala?Gln?Glu?Ser?Gln

165 170 175

Leu?Ser?His?Leu?Ile?Glu?Ala?Ile?Glu?Asn?Asp?Lys?Val?Ser?Ser?Asp

180 185 190

Phe?Asn?Gln?Ile?Ala?Leu?ValIle?Asp?Gly?Phe?Thr?Arg?Phe?Ser?Ala

195 200 205

Glu?Glu?Glu?Arg?Val?Val?Asp?Leu?Leu?His?Gly?Lys?Gly?Val?Glu?Ile

210 215 220

Val?Ile?Gly?Ala?Tyr?Ala?Ser?Lys?Lys?Ala?Tyr?Thr?Ser?Pro?Phe?Ser

225 230 235 240

Glu?Gly?Asn?Leu?Tyr?Gln?Ala?Ser?Val?Lys?Phe?Leu?His?His?Leu?Ala

245 250 255

Ser?Lys?Tyr?Gln?Thr?Pro?Ala?Gln?Asp?Cys?Ser?Gln?Thr?His?Glu?Lys

260 265 270

Met?Asp?Ser?Phe?Asp?Lys?Ala?Ser?Arg?Leu?Leu?Glu?Ser?Ser?Tyr?Asp

275 280 285

Phe?Ser?Glu?Leu?Ala?Leu?Asp?Val?Asp?Glu?Lys?Asp?Arg?Glu?Asn?Leu

290 295 300

Gln?Ile?Trp?Ser?Cys?Leu?Thr?Gln?Lys?Glu?Glu?Leu?Glu?Leu?Val?Ala

305 310 315 320

Arg?Ser?Ile?Arg?Gln?Lys?Leu?His?Glu?Asn?Ser?Asp?Leu?Ser?Tyr?Lys

325 330 335

His?Phe?Arg?Ile?Leu?Leu?Gly?Asp?Val?Ala?Ser?Tyr?Gln?Leu?Ser?Leu

340 345 350

Lys?Thr?Ile?Phe?Asp?Gln?Tyr?Gln?Ile?Pro?Phe?Tyr?Leu?Gly?Arg?Ser

355 360 365

Glu?Ala?Met?Ala?His?His?Pro?Leu?Thr?Gln?Phe?Val?Glu?Ser?Ile?Leu

370 375 380

Ala?Leu?Lys?Arg?Tyr?Arg?Phe?Arg?Gln?Glu?Asp?Leu?Ile?Asn?Leu?Leu

385 390 395 400

Arg?Thr?Asp?Leu?Tyr?Thr?Asp?Leu?Ser?Gln?Ser?Asp?Ile?Asp?Ala?Phe

405 410 415

Glu?Gln?Tyr?Ile?Arg?Tyr?Leu?Gly?Ile?Asn?Gly?Leu?Pro?Ala?Phe?Gln

420 425 430

Gln?Thr?Phe?Thr?Lys?Ser?His?His?Gly?Lys?Phe?Asn?Leu?Glu?Arg?Leu

435 440 445

Asn?Val?Leu?Arg?Leu?Arg?Ile?Leu?Ala?Pro?Leu?Glu?Thr?Leu?Phe?Ala

450 455 460

Ser?Arg?Lys?Gln?Lys?Ala?Glu?Lys?Leu?Leu?Gln?Lys?Trp?Ser?Val?Phe

465 470 475 480

Leu?Lys?Glu?Gly?Ala?Val?Thr?Lys?Gln?Leu?Gln?Asp?Leu?Thr?Thr?Thr

485 490 495

Leu?Glu?Ala?Val?Glu?Gln?Glu?Arg?Gln?Ala?Glu?Val?Trp?Lys?Ala?Phe

500 505 510

Cys?His?Val?Leu?Glu?Gln?Phe?Ala?Thr?Val?Phe?Ala?Gly?Ser?Gln?Val

515 520 525

Ser?Leu?Glu?Asp?Phe?Leu?Ala?Leu?Leu?His?Ser?Gly?Met?Ser?Leu?Ser

530 535 540

Gln?Tyr?Arg?Thr?Ile?Pro?Ala?Thr?Val?Asp?Thr?Val?Leu?Val?Gln?Ser

545 550 555 560

Tyr?Asp?Leu?Ile?Ala?Pro?Leu?Thr?Ala?Asp?Phe?Val?Tyr?Ala?Ile?Gly

565 570 575

Leu?Thr?Gln?Asp?Asn?Leu?Pro?Lys?Ile?Ser?Gln?Asn?Thr?Ser?Leu?Leu

580 585 590

Thr?Asp?Glu?Glu?Arg?Gln?Asn?Leu?Asn?Gln?Ala?Thr?Glu?Glu?Gly?Val

595 600 605

Gln?Leu?Leu?Ile?Ala?Ser?Ser?Glu?Asn?Leu?Lys?Lys?Asn?Arg?Tyr?Thr

610 615 620

Met?Leu?Ser?Leu?Val?Asn?Ser?Ala?Arg?Lys?Gln?Leu?Phe?Leu?Ser?Ala

625 630 635 640

Pro?Ser?Leu?Phe?Asn?Glu?Ser?Glu?Ser?Lys?Glu?Ser?Ala?Tyr?Leu?Gln

645 650 655

Glu?Leu?Ile?His?Phe?Gly?Phe?Arg?Arg?Arg?Glu?Lys?Arg?Met?Asn?His

660 665 670

Lys?Gly?Leu?Ser?Lys?Glu?Asp?Met?Gly?Ser?Tyr?His?Ser?Leu?Leu?Ser

675 680 685

Ser?Leu?Val?Ala?Tyr?His?Gln?Gln?Gly?Glu?Met?Ser?Asp?Thr?Glu?Gln

690 695 700

Asp?Leu?Thr?Phe?Val?Lys?Val?Leu?Ser?Arg?Val?Ile?Gly?Lys?Lys?Leu

705 710 715 720

Asp?Gln?Gln?Gly?Leu?Glu?Asn?Pro?Ala?Ile?Pro?Thr?Ser?Pro?Ser?Ser

725 730 735

Lys?Thr?Leu?Ala?Lys?Asp?Thr?Leu?Gln?Ala?Leu?Tyr?Pro?Ala?Lys?Gln

740 745 750

Glu?Phe?Tyr?Leu?Ser?Thr?Ser?Gly?Leu?Thr?Glu?Phe?Tyr?Arg?Asn?Glu

755 760 765

Tyr?Ser?Tyr?Phe?Leu?Arg?Tyr?Val?Leu?Gly?Leu?Gln?Glu?Glu?Leu?Arg

770 775 780

Leu?His?Pro?Asp?Ala?Arg?Ser?His?Gly?Asn?Phe?Leu?His?Arg?Ile?Phe

785 790 795 800

Glu?Arg?Ala?Leu?Gln?Leu?Pro?Asn?Glu?Asp?Ser?Phe?Asp?Gln?Arg?Leu

805 810 815

Glu?Gln?Ala?Ile?Gln?Glu?Thr?Ser?Gln?Glu?Arg?Glu?Phe?Glu?Ala?Ile

820 825 830

Tyr?Gln?Glu?Ser?Leu?Glu?Ala?Gln?Phe?Thr?Lys?Glu?Val?Leu?Leu?Asp

835 840 845

Val?Ala?Arg?Thr?Thr?Gly?His?Ile?Leu?Arg?His?Asn?Pro?Ala?Ile?Glu

850 855 860

Thr?Ile?Lys?Glu?Glu?Ala?Asn?Phe?Gly?Gly?Lys?Asp?Gln?Ala?Phe?Ile

865 870 875 880

Gln?Leu?Asp?Asn?Gly?Arg?Ser?Val?Phe?Val?Arg?Gly?Lys?Val?Asp?Arg

885 890 895

Ile?Asp?Arg?Leu?Lys?Ala?Asn?Gly?Ala?Ile?Gly?Val?Val?Asp?Tyr?Lys

900 905 910

Ser?Ser?Leu?Thr?Gln?Phe?Gln?Phe?Pro?His?Phe?Phe?Asn?Gly?Leu?Asn

915 920 925

Ser?Gln?Leu?Pro?Thr?Tyr?Leu?Ala?Ala?Leu?Lys?Arg?Glu?Gly?Glu?Gln

930 935 940

Asn?Phe?Phe?Gly?Ala?Met?Tyr?Leu?Glu?Met?Ala?Glu?Pro?Val?Gln?Ser

945 950 955 960

Leu?Met?Ala?Val?Lys?Ser?Leu?Ala?Gly?Ala?Val?Val?Glu?Ala?Ser?Lys

965 970 975

Ser?Met?Lys?Tyr?Gln?Gly?Leu?Phe?Leu?Glu?Lys?Glu?Ser?Ser?Tyr?Leu

980 985 990

Gly?Glu?Phe?Tyr?Asn?Lys?Asn?Lys?Ala?Asn?Gln?Leu?Thr?Asp?Glu?Glu

995 1000 1005

Phe?Gln?Leu?Leu?Leu?Asp?Tyr?Asn?Ala?Tyr?Leu?Tyr?Lys?Lys?Ala?Ala

1010 1015 1020

Glu?Lys?Ile?Leu?Ala?Gly?Arg?Phe?Ala?Ile?Asn?Pro?Tyr?Thr?Glu?Asn

1025 1030 1035 1040

Gly?Arg?Ser?Ile?Ala?Pro?Tyr?Val?Gln?Gln?His?Gln?Ala?Ile?Thr?Gly

1045 1050 1055

Phe?Glu?Ala?Asn?Tyr?His?Leu?Gly?Gln?Ala?Arg?Phe?Leu?Glu?Lys?Leu

1060 1065 1070

Asp?Leu?Ala?Asp?Gly?Lys?Arg?Leu?Val?Gly?Glu?Lys?Leu?Lys?Gln?Ala

1075 1080 1085

Trp?Leu?Glu?Lys?Ile?Arg?Glu?Glu?Leu?Asn?Arg

1090 1095

<210>12

<211>1216

<212>PRT

＜213〉streptococcus pneumoniae

<400>12

Met?Lys?Leu?Ile?Pro?Phe?Leu?Ser?Glu?Glu?Glu?Ile?Gln?Lys?Leu?Gln

1 5 10 15

Glu?Ala?Glu?Ala?Asn?Ser?Ser?Lys?Glu?Gln?Lys?Lys?Thr?Ala?Glu?Gln

20 25 30

Ile?Glu?Ala?Ile?Tyr?Thr?Ser?Ala?Gln?Asn?Ile?Leu?Val?Ser?Ala?Ser

35 40 45

Ala?Gly?Ser?Gly?Lys?Thr?Phe?Val?Met?Ala?Glu?Arg?Ile?Leu?Asp?Gln

50 55 60

Leu?Ala?Arg?Gly?Val?Glu?Ile?Ser?Gln?Leu?Phe?Ile?Ser?Thr?Phe?Thr

65 70 75 80

Val?LysAla?Ala?Thr?Glu?Leu?Lys?Glu?Arg?Leu?Glu?Lys?Lys?Ile?Ser

85 90 95

Lys?Lys?Ile?Gln?Glu?Thr?Asp?Asp?Val?Asp?Leu?Lys?Gln?His?Leu?Gly

100 105 110

Arg?Gln?Leu?Ala?Asp?Leu?Pro?Asn?Ala?Ala?Ile?Gly?Thr?Met?Asp?Ser

115 120 125

Phe?Thr?Gln?Lys?Phe?Leu?Gly?Lys?His?Gly?Tyr?Leu?Leu?Asp?Ile?Ala

130 135 140

Pro?Asn?Phe?Arg?Ile?Leu?Gln?Asn?Gln?Ser?Glu?Gln?Leu?Ile?Leu?Glu

145 150 155 160

Asn?Glu?Val?Phe?His?Glu?Val?Phe?Glu?Ala?His?Tyr?Gln?Gly?Lys?Gln

165 170 175

Lys?Glu?Thr?Phe?Ser?His?Leu?Leu?Lys?Asn?Phe?Ala?Gly?Arg?Gly?Lys

180 185 190

Asp?Glu?Arg?Gly?Leu?Arg?Gln?Gln?Val?Tyr?Lys?Ile?Tyr?Asp?Phe?Leu

195 200 205

Gln?Ser?Thr?Ser?Asn?Pro?Gln?Lys?Trp?Leu?Ser?Glu?Ser?Phe?Leu?Lys

210 215 220

Gly?Phe?Glu?Lys?Ala?Asp?Phe?Thr?Ser?Glu?Lys?Glu?Lys?Leu?Thr?Glu

225 230 235 240

Gln?Ile?Lys?Gln?Ala?Leu?Trp?Asp?Leu?Glu?Ser?Phe?Phe?Arg?Tyr?His

245 250 255

Leu?Asp?Asn?Asp?Ala?Lys?Glu?Phe?Ala?Lys?Ala?Ala?Tyr?Leu?Glu?Asn

260 265 270

Val?Gln?Leu?Ile?Leu?Asp?Glu?Ile?Gly?Ser?Leu?Asn?Gln?Glu?Ser?Asp

275 280 285

Ser?Gln?Ala?Tyr?Gln?Ala?Val?Leu?Ala?Arg?Val?Val?Ala?Ile?Ser?Lys

290 295 300

Glu?Lys?Asn?Gly?Arg?Ala?Leu?Thr?Asn?Ala?Ser?Arg?Lys?Ala?Asp?Leu

305 310 315 320

Lys?Pro?Leu?Ala?Asp?Ala?Tyr?Asn?Glu?Glu?Arg?Lys?Thr?Gln?Phe?Ala

325 330 335

Lys?Leu?Gly?Gln?Leu?Ser?Asp?Gln?Ile?Ala?Ile?Leu?Asp?Tyr?Gln?Glu

340 345 350

Arg?Tyr?His?Gly?Asp?Thr?Trp?Lys?Leu?Ala?Lys?Thr?Phe?Gln?Ser?Phe

355 360 365

Met?Ser?Asp?Phe?Val?Glu?Ala?Tyr?Arg?Gln?Arg?Lys?Arg?Gln?Glu?Asn

370 375 380

Ala?Phe?Glu?Phe?Ala?Asp?Ile?Ser?His?Tyr?Thr?Ile?Glu?Ile?Leu?Glu

385 390 395 400

Asn?Phe?Pro?Gln?Val?Arg?Glu?Ser?Tyr?Gln?Glu?Arg?Phe?His?Glu?Val

405 410 415

Met?Val?Asp?Glu?Tyr?Gln?Asp?Thr?Asn?His?Ile?Gln?Glu?Arg?Met?Leu

420 425 430

Glu?Leu?Leu?Ser?Asn?Gly?His?Asn?Arg?Phe?Met?Val?Gly?Asp?Ile?Lys

435 440 445

Gln?Ser?Ile?Tyr?Arg?Phe?Arg?Gln?Ala?Asp?Pro?Gln?Ile?Phe?Asn?Glu

450 455 460

Lys?Phe?Gln?Arg?Tyr?Ala?Gln?Asn?Pro?Gln?Glu?Gly?Arg?Leu?Ile?Ile

465 470 475 480

Leu?Lys?Glu?Asn?Phe?Arg?Ser?Ser?Ser?Glu?Val?Leu?Ser?Ala?Thr?Asn

485 490 495

Asp?Val?Phe?Glu?Arg?Leu?Met?Asp?Gln?Glu?Val?Gly?Glu?Ile?Asn?Tyr

500 505 510

Asp?Asn?Lys?His?Gln?Leu?Val?Phe?Ala?Asn?Thr?Lys?Leu?Thr?Pro?Asn

515 520 525

Pro?Asp?Asn?Lys?Ala?Ala?Phe?Leu?Leu?Tyr?Asp?Lys?Asp?Asp?Thr?Gly

530 535 540

Glu?Glu?Glu?Glu?Ser?Gln?Thr?Glu?Thr?Lys?Leu?Thr?Gly?Glu?Met?Arg

545 550 555 560

Leu?Val?Ile?Lys?Glu?Ile?Leu?Lys?Leu?His?Gln?Glu?Lys?Gly?Val?Ala

565 570 575

Phe?Lys?Glu?Ile?Ala?Leu?Leu?Thr?Ser?Ser?Arg?Ser?Arg?Asn?Asp?Gln

580 585 590

Ile?Leu?Leu?Ala?Leu?Ser?Glu?Tyr?Gly?Ile?Pro?Val?Lys?Thr?Asp?Gly

595 600 605

Glu?Gln?Asn?Asn?Tyr?Leu?Gln?Ser?Leu?Glu?Val?Gln?Val?Met?Leu?Asp

610 615 620

Thr?Leu?Arg?Val?Ile?His?Asn?Pro?Leu?Gln?Asp?Tyr?Ala?Leu?Val?Ala

625 630 635 640

Leu?Met?Lys?Ser?Pro?Met?Phe?Gly?Phe?Asp?Glu?Asp?Glu?Leu?Ala?Arg

645 650 655

Leu?Ser?Leu?Gln?Lys?Ala?Glu?Asp?Lys?Val?His?Glu?Asn?Leu?Tyr?Glu

660 665 670

Lys?Leu?Val?Asn?Ala?Gln?Lys?Met?Ala?Ser?Ser?Gln?Lys?Gly?Leu?Ile

675 680 685

His?Thr?Ala?Leu?Ala?Glu?Lys?Leu?Lys?Gln?Phe?Met?Asp?Ile?Leu?Ala

690 695 700

Ser?Trp?Arg?Leu?Tyr?Ala?Lys?Thr?His?Ser?Leu?Tyr?Asp?Leu?Ile?Trp

705 710 715 720

Lys?Ile?Tyr?Asn?Asp?Arg?Phe?Tyr?Tyr?Asp?Tyr?Val?Gly?Ala?Leu?Pro

725 730 735

Asn?Gly?Pro?Ala?Arg?Gln?Ala?Asn?Leu?Tyr?Ala?Leu?Ala?Leu?Arg?Ala

740 745 750

Asp?Gln?Phe?Glu?Lys?Ser?Asn?Phe?Lys?Gly?Leu?Ser?Arg?Phe?Ile?Arg

755 760 765

Met?Ile?Asp?Gln?Val?Leu?Glu?Ala?Gln?His?Asp?Leu?Ala?Ser?Val?Ala

770 775 780

Val?Ala?Pro?Pro?Lys?Asp?Ala?Val?Glu?Leu?Met?Thr?Ile?His?Lys?Ser

785 790 795 800

Lys?Gly?Leu?Glu?Phe?Pro?Tyr?Val?Phe?Ile?Leu?Asn?Met?Asp?Gln?Asp

805 810 815

Phe?Asn?Lys?Gln?Asp?Ser?Met?Ser?Glu?Val?Ile?Leu?Ser?Arg?Gln?Asn

820 825 830

Gly?Leu?Gly?Val?Lys?Tyr?Ile?Ala?Lys?Met?Glu?Thr?Gly?Ala?Val?Glu

835 840 845

Asp?His?Tyr?Pro?Lys?Thr?Ile?Lys?Leu?Ser?Ile?Pro?Ser?Leu?Thr?Tyr

850 855 860

Arg?Gln?Asn?Glu?Glu?Glu?Leu?Gln?Leu?Ala?Ser?Tyr?Ser?Glu?Gln?Met

865 870 875 880

Arg?Leu?Leu?Tyr?Val?Ala?Met?Thr?Arg?Ala?Glu?Lys?Lys?Leu?Tyr?Leu

885 890 895

Val?Gly?Lys?Gly?Ser?Arg?Glu?Lys?Leu?Glu?Ser?Lys?Glu?Tyr?Pro?Ala

900 905 910

Ala?Lys?Asn?Gly?Lys?Leu?Asn?Ser?Asn?Thr?Arg?Leu?Gln?Ala?Arg?Asn

915 920 925

Phe?Gln?Asp?Trp?Leu?Trp?Ala?Ile?Ser?Lys?Val?Phe?Thr?Lys?Asp?Lys

930 935 940

Leu?Asn?Phe?Ser?Tyr?Arg?Phe?Ile?Gly?Glu?Asp?Gln?Leu?Thr?Arg?Glu

945 950 955 960

Ala?Ile?Gly?Glu?Leu?Glu?Thr?Lys?Ser?Pro?Leu?Gln?Asp?Ser?Ser?Gln

965 970 975

Ala?Asp?Asn?Arg?Gln?Ser?Asp?Thr?Ile?Lys?Glu?Ala?Leu?Glu?Met?Leu

980 985 990

Lys?Glu?Val?Glu?Val?Tyr?Asn?Thr?Leu?His?Arg?Ala?Ala?Ile?Glu?Leu

995 1000 1005

Pro?Ser?Val?Gln?Thr?Pro?Ser?Gln?Ile?Lys?Lys?Phe?Tyr?Glu?Pro?Val

1010 1015 1020

Met?Asp?Met?Glu?Gly?Val?Glu?Ile?Ala?Gly?Gln?Gly?Gln?Ser?Val?Gly

1025 1030 1035 1040

Lys?Lys?Ile?Ser?Phe?Asp?Leu?Pro?Asp?Phe?Ser?Thr?Lys?Glu?Lys?Val

1045 1050 1055

Thr?Gly?Ala?Glu?Ile?Gly?Ser?Ala?Thr?His?Glu?Leu?Met?Gln?Arg?Ile

1060 1065 1070

Asp?Leu?Ser?Gln?Gln?Leu?Thr?Leu?Ala?Ser?Leu?Thr?Glu?Thr?Leu?Lys

1075 1080 1085

Gln?Val?Gln?Thr?Ser?Gln?Ala?Val?Arg?Asp?Lys?Ile?Asn?Leu?Asp?Lys

1090 1095 1100

Ile?Leu?Ala?Phe?Phe?Asp?Thr?Val?Leu?Gly?Gln?Glu?Ile?Leu?Ala?Asn

1105 1110 1115 1120

Thr?Asp?His?Leu?Tyr?Arg?Glu?Gln?Pro?Phe?Ser?Met?Leu?Lys?Arg?Asp

1125 1130 1135

Gln?Lys?Ser?Gln?Glu?Asp?Phe?Val?Val?Arg?Gly?Ile?Leu?Asp?Gly?Tyr

1140 1145 1150

Leu?Leu?Tyr?Glu?Asn?Lys?Ile?Val?Leu?Phe?Asp?Tyr?Lys?Thr?Asp?Arg

1155 1160 1165

Tyr?Asp?Glu?Pro?Ser?Gln?Leu?Val?Asp?Arg?Tyr?Arg?Gly?Gln?Leu?Ala

1170 1175 1180

Leu?Tyr?Glu?Glu?Ala?Leu?Ser?Arg?Ala?Tyr?Ser?Ile?Glu?Asn?Ile?Glu

1185 1190 1195 1200

Lys?Tyr?Leu?Ile?Leu?Leu?Gly?Lys?Asp?Glu?Val?Gln?Val?Val?Lys?Val

1205 1210 1215

<210>13

<211>215

<212>PRT

＜213〉streptococcus pneumoniae

<400>13

Met?Glu?Leu?Ala?Arg?His?Ala?Glu?Ser?Leu?Gly?Val?Asp?Ala?Ile?Ala

1 5 10 15

Thr?Ile?Pro?Pro?Ile?Tyr?Phe?Arg?Leu?Pro?Glu?Tyr?Ser?Val?Ala?Lys

20 25 30

Tyr?Trp?Asn?Asp?Ile?Ser?Ser?Ala?Ala?Pro?Asn?Thr?Asp?Tyr?Val?Ile

35 40 45

Tyr?Asn?Ile?Pro?Gln?Leu?Ala?Gly?Val?Ala?Leu?Thr?Pro?Ser?Leu?Tyr

50 55 60

Thr?Glu?Met?Leu?Lys?Asn?Pro?Arg?Val?Ile?Gly?Val?Lys?Asn?Ser?Ser

65 70 75 80

Met?Pro?Val?Gln?Asp?Ile?Gln?Thr?Phe?Val?Ser?Leu?Gly?Gly?Glu?Asp

85 90 95

His?Ile?Val?Phe?Asn?Gly?Pro?Asp?Glu?Gln?Phe?Leu?Gly?Gly?Arg?Leu

100 105 110

Met?Gly?Ala?Arg?Ala?Gly?Ile?Gly?Gly?Thr?Tyr?Gly?Ala?Met?Pro?Glu

115 120 125

Leu?Phe?Leu?Lys?Leu?Asn?Gln?Leu?Ile?Ala?Asp?Lys?Asp?Leu?Glu?Thr

130 135 140

Ala?Arg?Glu?Leu?Gln?Tyr?Ala?Ile?Asn?Ala?Ile?Ile?Gly?Lys?Leu?Thr

145 150 155 160

Ser?Ala?His?Gly?Asn?Met?Tyr?Gly?Val?Ile?Lys?Glu?Val?Leu?Lys?Ile

165 170 175

Asn?Glu?Gly?Leu?Asn?Ile?Gly?Ser?Val?Arg?Ser?Pro?Leu?Thr?Pro?Val

180 185 190

Thr?Glu?Glu?Asp?Arg?Pro?Val?Val?Glu?Ala?Ala?Ala?Ala?Leu?Ile?Arg

195 200 205

Glu?Thr?Lys?Glu?Arg?Phe?Leu

210 215

<210>14

<211>407

<212>PRT

＜213〉streptococcus pneumoniae

<400>14

Met?Tyr?Lys?Thr?Lys?Cys?Leu?Arg?Glu?Lys?Leu?Val?Leu?Phe?Leu?Lys

1 5 10 15

Ile?Phe?Phe?Pro?Ile?Leu?Ile?Tyr?Gln?Phe?Ala?Asn?Tyr?Ser?Ala?Ser

20 25 30

Phe?Val?Asp?Thr?Ala?Met?Thr?Gly?Gln?Tyr?Asn?Thr?Met?Asp?Leu?Ala

35 40 45

Gly?Val?Ser?Met?Ala?Thr?Ser?Ile?Trp?Asn?Pro?Phe?Phe?Thr?Phe?Leu

50 55 60

Thr?Gly?Ile?Val?Ser?Ala?Leu?Val?Pro?Ile?Ile?Gly?His?His?Leu?Gly

65 70 75 80

Arg?Gly?Lys?Lys?Glu?Glu?Val?Ala?ser?Asp?Phe?Tyr?Gln?Phe?Ile?Tyr

85 90 95

Leu?Ala?Leu?Gly?Leu?Ser?Val?Val?Leu?Leu?Gly?Met?Val?Leu?Phe?Leu

100 105 110

Ala?Pro?Ile?Ile?Leu?Asn?His?Ile?Gly?Leu?Glu?Ala?Ala?Val?Ala?Ala

115 120 125

Val?Ala?Val?Arg?Tyr?Leu?Trp?Phe?Leu?Ser?Ile?Gly?Ile?Ile?Pro?Leu

130 135 140

Leu?Leu?Phe?Ser?Val?Ile?Arg?Ser?Leu?Leu?Asp?Ser?Leu?Gly?Leu?Thr

145 150 155 160

Lys?Leu?Ser?Met?Tyr?Leu?Met?Leu?Leu?Leu?Leu?Pro?Leu?Asn?Ser?Gly

165 170 175

Phe?Asn?Tyr?Leu?Leu?Ile?Tyr?Gly?Ala?Phe?Gly?Val?Pro?Glu?Leu?Gly

180 185 190

Gly?Ala?Gly?Ala?Gly?Leu?Gly?Thr?Ser?Leu?Ala?Tyr?Trp?Val?Leu?Leu

195 200 205

Gly?Ile?Ser?Val?Leu?Val?Leu?Phe?Lys?Gln?Glu?Lys?Leu?Lys?Ala?Leu

210 215 220

His?Leu?Glu?Lys?Arg?Ile?Pro?Leu?Asn?Met?Asp?Lys?Ile?Lys?Glu?Gly

225 230 235 240

Val?Arg?Leu?Gly?Leu?Pro?Ile?Gly?Gly?Thr?Val?Phe?Ala?Glu?Val?Ala

245 250 255

Ile?Phe?Ser?Val?Val?Gly?Leu?Ile?Met?Ala?Lys?Phe?Ser?Pro?Leu?Ile

260 265 270

Ile?Ala?Ser?His?Gln?Ser?Ala?Met?Asn?Phe?Ser?Ser?Leu?Met?Tyr?Ala

275 280 285

Phe?Pro?Met?Ser?Ile?Ser?Ser?Ala?Met?Ala?Ile?Val?Val?Ser?Tyr?Glu

290 295 300

Val?Gly?Ala?Lys?Arg?Phe?Asp?Asp?Ala?Lys?Thr?Tyr?Ile?Gly?Leu?Gly

305 310 315 320

Arg?Trp?Thr?Ala?Leu?Ile?Phe?Ala?Ala?Phe?Thr?Leu?Thr?Phe?Leu?Tyr

325 330 335

Ile?Phe?Arg?Gly?Asn?Val?Ala?Ser?Leu?Tyr?Gly?Asn?Asp?Pro?Lys?Phe

340 345 350

Ile?Asp?Leu?Thr?Val?Arg?Phe?Leu?Thr?Tyr?ser?Leu?Phe?Phe?Gln?Leu

355 360 365

Ala?Asp?Thr?Phe?Ala?Ala?Pro?Leu?Gln?Gly?Ile?Leu?Arg?Gly?Tyr?Lys

370 375 380

Asp?Thr?Val?Ile?Pro?Phe?Tyr?Leu?Gly?Leu?Leu?Gly?Tyr?Trp?Gly?Val

385 390 395 400

Ala?Ile?Pro?Val?Tyr?Ala?Ile

405

<210>15

<211>189

<212>PRT

＜213〉streptococcus pneumoniae

<400>15

Met?Ser?Thr?Leu?Ala?Lys?Ile?Glu?Ala?Leu?Leu?Phe?Val?Ala?Gly?Glu

1 5 10 15

Asp?Gly?Ile?Arg?Val?Arg?Gln?Leu?Ala?Glu?Leu?Leu?Ser?Leu?Pro?Pro

20 25 30

Thr?Gly?Ile?Gln?Gln?Ser?Leu?Gly?Lys?Leu?Ala?Gln?Lys?Tyr?Glu?Lys

35 40 45

Asp?Pro?Asp?Ser?Ser?Leu?Ala?Leu?Ile?Glu?Thr?Ser?Gly?Ala?Tyr?Arg

50 55 60

Leu?Val?Thr?Lys?Pro?Gln?Phe?Ala?Glu?Ile?Leu?Lys?Glu?Tyr?Ser?Lys

65 70 75 80

Ala?Pro?Ile?Asn?Gln?Ser?Leu?Ser?Arg?Ala?Ala?Leu?Glu?Thr?Leu?Ser

85 90 95

Ile?Ile?Ala?Tyr?Lys?Gln?Pro?Ile?Thr?Arg?Ile?Glu?Ile?Asp?Ala?Ile

100 105 110

Arg?Gly?Val?Asn?Ser?Ser?Gly?Ala?Leu?AIa?Lys?Leu?Gln?Ala?Phe?Asp

115 120 125

Leu?Ile?Lys?Glu?Asp?Gly?Lys?Lys?Glu?Val?Leu?Gly?Arg?Pro?Asn?Leu

130 135 140

Tyr?Val?Thr?Thr?Asp?Tyr?Phe?Leu?Asp?Tyr?Met?Gly?Ile?Asn?His?Leu

145 150 155 160

Glu?Glu?Leu?Pro?Val?Ile?Asp?Glu?Leu?Glu?Ile?Gln?Ala?Gln?Glu?Ser

165 170 175

Gln?Leu?Phe?Gly?Glu?Arg?Ile?Glu?Glu?Asp?Glu?Asn?Gln

180 185

<210>16

<211>311

<212>PRT

＜213〉streptococcus pneumoniae

<400>16

Met?Asp?Thr?Met?Ile?Ser?Arg?Phe?Phe?Arg?His?Leu?Phe?Glu?Ala?Leu

1 5 10 15

Lys?Ser?Leu?Lys?Arg?Asn?Gly?Trp?Met?Thr?Val?Ala?Ala?Val?Ser?Ser

20 25 30

Val?Met?Ile?Thr?Leu?Thr?Leu?Val?Ala?Ile?Phe?Ala?Ser?Val?Ile?Phe

35 40 45

Asn?Thr?Ala?Lys?Leu?Ala?Thr?Asp?Ile?Glu?Asn?Asn?Val?Arg?Val?Val

50 55 60

Val?Tyr?Ile?Arg?Lys?Asp?Val?Glu?Asp?Asn?Ser?Gln?Thr?Ile?Glu?Lys

65 70 75 80

Glu?Gly?Gln?Thr?Val?Thr?Asn?Asn?Asp?Tyr?His?Lys?Val?Tyr?Asp?Ser

85 90 95

Leu?Lys?Asn?Met?Ser?Thr?Val?Lys?Ser?Val?Thr?Phe?Ser?Ser?Lys?Glu

100 105 110

Glu?Gln?Tyr?Glu?Lys?Leu?Thr?Glu?Ile?Met?Gly?Asp?Asn?Trp?Lys?Ile

115 120 125

Phe?Glu?Gly?Asp?Ala?Asn?Pro?Leu?Tyr?Asp?Ala?Tyr?Ile?Val?Glu?Ala

130 135 140

Asn?Thr?Pro?Asn?Asp?Val?Lys?Thr?Ile?Ala?Glu?Asp?Ala?Lys?Lys?Ile

145 150 155 160

Glu?Gly?Val?Ser?Glu?Val?Gln?Asp?Gly?Gly?Ala?Asn?Thr?Glu?Arg?Leu

165 170 175

Phe?Lys?Leu?Ala?Ser?Phe?Ile?Arg?Val?Trp?Gly?Leu?Gly?Ile?Ala?Ala

180 185 190

Leu?Leu?Ile?Phe?Ile?Ala?Val?Phe?Leu?Ile?Ser?Asn?Thr?Ile?Arg?Ile

195 200 205

Thr?Ile?Ile?Ser?Arg?Ser?Arg?Glu?Ile?Gln?Ile?Met?Arg?Leu?Val?Gly

210 215 220

Ala?Lys?Asn?Ser?Tyr?Ile?Arg?Gly?Pro?Phe?Leu?Leu?Glu?Gly?Ala?Phe

225 230 235 240

Ile?Gly?Leu?Leu?Gly?Ala?Ile?Ala?Pro?Ser?Val?Leu?Val?Phe?Ile?Val

245 250 255

Tyr?Gln?Ile?Val?Tyr?Gln?Ser?Val?Asn?Lys?Ser?Leu?Val?Gly?Gln?Asn

260 265 270

Leu?Ser?Met?Ile?Ser?Pro?Asp?Leu?Phe?Ser?Pro?Leu?Met?Ile?Ala?Leu

275 280 285

Leu?Phe?Val?Ile?Gly?Val?Phe?Ile?Gly?Ser?Leu?Gly?Ser?Gly?Ile?Ser

290 295 300

Met?Arg?Arg?Phe?Leu?Lys?Ile

305 310

<210>17

<211>658

<212>PRT

＜213〉streptococcus pneumoniae

<400>17

Met?Lys?Lys?Val?Arg?Phe?Ile?Phe?Leu?Ala?Leu?Leu?Phe?Phe?Leu?Ala

1 5 10 15

Ser?Pro?Glu?Gly?Ala?Met?Ala?Ser?Asp?Gly?Thr?Trp?Gln?Gly?Lys?Gln

20 25 30

Tyr?Leu?Lys?Glu?Asp?Gly?Ser?Gln?Ala?Ala?Asn?Glu?Trp?Val?Phe?Asp

35 40 45

Thr?His?Tyr?Gln?Ser?Trp?Phe?Tyr?Ile?Lys?Ala?Asp?Ala?Asn?Tyr?Ala

50 55 60

Glu?Asn?Glu?Trp?Leu?Lys?Gln?Gly?Asp?Asp?Tyr?Phe?Tyr?Leu?Lys?Ser

65 70 75 80

Gly?Gly?Tyr?Met?Ala?Lys?Ser?Glu?Trp?Val?Glu?Asp?Lys?Gly?Ala?Phe

85 90 95

Tyr?Tyr?Leu?Asp?Gln?Asp?Gly?Lys?Met?Lys?Arg?Asn?Ala?Trp?Val?Gly

100 105 110

Thr?Ser?Tyr?Val?Gly?Ala?Thr?Gly?Ala?Lys?Val?Ile?Glu?Asp?Trp?Val

115 120 125

Tyr?Asp?Ser?Gln?Tyr?Asp?Ala?Trp?Phe?Tyr?Ile?Lys?Ala?Asp?Gly?Gln

130 135 140

His?Ala?Glu?Lys?Glu?Trp?Leu?Gln?Ile?Lys?Gly?Lys?Asp?Tyr?Tyr?Phe

145 150 155 160

Lys?Ser?Gly?Gly?Tyr?Leu?Leu?Thr?Ser?Gln?Trp?Ile?Asn?Gln?Ala?Tyr

165 170 175

Val?Asn?Ala?Ser?Gly?Ala?Lys?Val?Gln?Gln?Gly?Trp?Leu?Phe?Asp?Lys

180 185 190

Gln?Tyr?Gln?Ser?Trp?Phe?Tyr?Ile?Lys?Glu?Asn?Gly?Asn?Tyr?Ala?Asp

195 200 205

Lys?Glu?Trp?Ile?Phe?Glu?Asn?Gly?His?Tyr?Tyr?Tyr?Leu?Lys?Ser?Gly

210 215 220

Gly?Tyr?Met?Ala?Ala?Asn?Glu?Trp?Ile?Trp?Asp?Lys?Glu?Ser?Trp?Phe

225 230 235 240

Tyr?Leu?Lys?Phe?Asp?Gly?Lys?Met?Ala?Glu?Lys?Glu?Trp?Val?Tyr?Asp

245 250 255

Ser?His?Ser?Gln?Ala?Trp?Tyr?Tyr?Phe?Lys?Ser?Gly?Gly?Tyr?Met?Thr

260 265 270

Ala?Asn?Glu?Trp?Ile?Trp?Asp?Lys?Glu?Ser?Trp?Phe?Tyr?Leu?Lys?Ser

275 280 285

Asp?Gly?Lys?Ile?Ala?Glu?Lys?Glu?Trp?Val?Tyr?Asp?Ser?His?Ser?Gln

290 295 300

Ala?Trp?Tyr?Tyr?Phe?Lys?Ser?Gly?Gly?Tyr?Met?Thr?Ala?Asn?Glu?Trp

305 310 315 320

Ile?Trp?Asp?Lys?Glu?Ser?Trp?Phe?Tyr?Leu?Lys?Ser?Asp?Gly?Lys?Ile

325 330 335

Ala?Glu?Lys?Glu?Trp?Val?Tyr?Asp?Ser?His?Ser?Gln?Ala?Trp?Tyr?Tyr

340 345 350

Phe?Lys?Ser?Gly?Gly?Tyr?Met?Ala?Lys?Asn?Glu?Thr?Val?Asp?Gly?Tyr

355 360 365

Gln?Leu?Gly?Ser?Asp?Gly?Lys?Trp?Leu?Gly?Gly?Lys?Thr?Thr?Asn?Glu

370 375 380

Asn?Ala?Ala?Tyr?Tyr?Gln?Val?Val?Pro?Val?Thr?Ala?Asn?Val?Tyr?Asp

385 390 395 400

Ser?Asp?Gly?Glu?Lys?Leu?Ser?Tyr?Ile?Ser?Gln?Gly?Ser?Val?Val?Trp

405 410 415

Leu?Asp?Lys?Asp?Arg?Lys?Ser?Asp?Asp?Lys?Arg?Leu?Ala?Ile?Thr?Ile

420 425 430

Ser?Gly?Leu?Ser?Gly?Tyr?Met?Lys?Thr?Glu?Asp?Leu?Gln?Ala?Leu?Asp

435 440 445

Ala?Ser?Lys?Asp?Phe?Ile?Pro?Tyr?Tyr?Glu?Ser?Asp?Gly?His?Arg?Phe

450 455 460

Tyr?His?Tyr?Val?Ala?Gln?Asn?Ala?Ser?Ile?Pro?Val?Ala?Ser?His?Leu

465 470 475 480

Ser?Asp?Met?Glu?Val?Gly?Lys?Lys?Tyr?Tyr?Ser?Ala?Asp?Gly?Leu?His

485 490 495

Phe?Asp?Gly?Phe?Lys?Leu?Glu?Asn?Pro?Phe?Leu?Phe?Lys?Asp?Leu?Thr

500 505 510

Glu?Ala?Thr?Asn?Tyr?Ser?Ala?Glu?Glu?Leu?Asp?Lys?Val?Phe?Ser?Leu

515 520 525

Leu?Asn?Ile?Asn?Asn?Ser?Leu?Leu?Glu?Asn?Lys?Gly?Ala?Thr?Phe?Lys

530 535 540

Glu?Ala?Glu?Glu?His?Tyr?His?Ile?Asn?Ala?Leu?Tyr?Leu?Leu?Ala?His

545 550 555 560

Ser?Ala?Leu?Glu?Ser?Asn?Trp?Gly?Arg?Ser?Lys?Ile?Ala?Lys?Asp?Lys

565 570 575

Asn?Asn?Phe?Phe?Gly?Ile?Thr?Ala?Tyr?Asp?Thr?Thr?Pro?Tyr?Leu?Ser

580 585 590

Ala?Lys?Thr?Phe?Asp?Asp?Val?Asp?Lys?Gly?Ile?Leu?Gly?Ala?Thr?Lys

595 600 605

Trp?Ile?Lys?Glu?Asn?Tyr?Ile?Asp?Arg?Gly?Arg?Thr?Phe?Leu?Gly?Asn

610 615 620

Lys?Ala?Ser?Gly?Met?Asn?Val?Glu?Tyr?Ala?Ser?Asp?Pro?Tyr?Trp?Gly

625 630 635 640

Glu?Lys?Ile?Ala?Ser?Val?Met?Met?Lys?Ile?Asn?Glu?Lys?Leu?Gly?Gly

645 650 655

Lys?Asp

<210>18

<211>288

<212>PRT

＜213〉streptococcus pneumoniae

<400>18

Met?Lys?Lys?Val?Leu?Gln?Lys?Tyr?Trp?Ala?Trp?Ala?Phe?Val?Val?Ile

1 5 10 15

Pro?Leu?Leu?Leu?Gln?Ala?Ile?Phe?Phe?Tyr?Val?Pro?Met?Phe?Gln?Gly

20 25 30

Ala?Phe?Tyr?Ser?Phe?Thr?Asn?Trp?Thr?Gly?Leu?Thr?Tyr?Asn?Tyr?Lys

35 40 45

Phe?Val?Gly?Leu?Asn?Asn?Phe?Lys?Leu?Leu?Phe?Met?Asp?Pro?Lys?Phe

50 55 60

Met?Asn?Ala?Ile?Gly?Phe?Thr?Ala?Ile?Ile?Ala?Ile?Ala?Met?Val?Val

65 70 75 80

Gly?Glu?Ile?Ala?Leu?Gly?Ile?Phe?Ile?Ala?Arg?Val?Leu?Asn?Ser?Lys

85 90 95

Ile?Lys?Gly?Gln?Thr?Phe?Phe?Arg?Ala?Trp?Phe?Phe?Phe?Pro?Ala?Val

100 105 110

Leu?Ser?Gly?Leu?Thr?Val?Ala?Leu?Ile?Phe?Lys?Gln?Val?Phe?Asn?Tyr

115 120 125

Gly?Leu?Pro?Ala?Ile?Gly?Asn?Ala?Leu?His?Ile?Glu?Phe?Phe?Gln?Thr

130 135 140

Ser?Leu?Leu?Gly?Thr?Lys?Trp?Gly?Ala?Ile?Phe?Ala?Ala?Val?Phe?Val

145 150 155 160

Leu?Leu?Trp?Gln?Gly?Val?Ala?Met?Pro?Ile?Ile?Ile?Phe?Leu?Ala?Gly

165 170 175

Leu?Gln?Ser?Ile?Pro?Thr?Glu?Ile?Thr?Glu?Ala?Ala?Arg?Ile?Asp?Gly

180 185 190

Ala?Thr?Ser?Lys?Gln?Val?Phe?Trp?Asn?Ile?Glu?Leu?Pro?Tyr?Leu?Leu

195 200 205

Pro?Ser?Val?Ser?Met?Val?Phe?Ile?Leu?Ala?Leu?Lys?Gly?Gly?Leu?Thr

210 215 220

Ala?Phe?Asp?Gln?Val?Phe?Ala?Met?Thr?Gly?Gly?Gly?Pro?Asn?Asn?Ala

225 230 235 240

Thr?Thr?Ser?Leu?Gly?Leu?Leu?Val?Tyr?Asn?Tyr?Ala?Phe?Lys?Asn?Asn

245 250 255

Gln?Phe?Gly?Tyr?Ala?Asn?Ala?Ile?Ala?Val?Ile?Leu?Phe?Phe?Leu?Ile

260 265 270

Val?Val?Ile?Ser?Ile?Ile?Gln?Leu?Arg?Val?Ser?Lys?Lys?Phe?Glu?Ile

275 280 285

<210>19

<211>278

<212>PRT

＜213〉streptococcus pneumoniae

<400>19

Met?Met?Lys?Gln?Asp?Glu?Arg?Lys?Ala?Leu?Ile?Gly?Lys?Tyr?Ile?Leu

1 5 10 15

Leu?Ile?Leu?Gly?Ser?Val?Leu?Ile?Leu?Val?Pro?Leu?Leu?Ala?Thr?Leu

20 25 30

Phe?Ser?Ser?Phe?Lys?Pro?Thr?Lys?Asp?Ile?Val?Asp?Asn?Phe?Phe?Gly

35 40 45

Phe?Pro?Thr?Asn?Phe?Thr?Trp?Asp?Asn?Phe?Ser?Arg?Leu?Leu?Ala?Asp

50 55 60

Gly?Ile?Gly?Gly?Tyr?Tyr?Trp?Asn?Ser?Val?Val?Ile?Thr?Val?Leu?Ser

65 70 75 80

Leu?Leu?Ala?Val?Met?Ile?Phe?Ile?Pro?Met?Ala?Ala?Tyr?Ser?Ile?Ala

85 90 95

Arg?Asn?Met?Ser?Lys?Arg?Lys?Ala?Phe?Thr?Ile?Met?Tyr?Thr?Leu?Leu

100 105 110

Ile?Leu?Gly?Ile?Phe?Val?Pro?Phe?Gln?Val?Ile?Met?Ile?Pro?Ile?Thr

115 120 125

Val?Met?Met?Ser?Lys?Leu?Gly?Leu?Ala?Asn?Thr?Phe?Gly?Leu?Ile?Leu

130 135 140

Leu?Tyr?Leu?Thr?Tyr?Ala?Ile?Pro?Gln?Thr?Leu?Phe?Leu?Tyr?Val?Gly

145 150 155 160

Tyr?Ile?Lys?Ile?Ser?Ile?Pro?Glu?Ser?Leu?Asp?Glu?Ala?Ala?Glu?Ile

165 170 175

Asp?Gly?Ala?Asn?Gln?Phe?Thr?Thr?Tyr?Phe?Arg?Ile?Ile?Phe?Pro?Met

180 185 190

Met?Lys?Pro?Met?His?Ala?Thr?Thr?Met?Ile?Ile?Asn?Ala?Leu?Trp?Phe

195 200 205

Trp?Asn?Asp?Phe?Met?Leu?Pro?Leu?Leu?Val?Leu?Asn?Arg?Asp?Ser?Lys

210 215 220

Met?Trp?Thr?Leu?Pro?Leu?Phe?Gln?Tyr?Asn?Tyr?Ala?Gly?Gln?Tyr?Phe

225 230 235 240

Asn?Asp?Tyr?Gly?Pro?Ser?Phe?Ala?Ser?Tyr?Val?Val?Gly?Ile?Ile?Ser

245 250 255

Ile?Thr?Ile?Val?Tyr?Leu?Phe?Phe?Gln?Arg?His?Ile?Ile?Ser?Gly?Met

260 265 270

Ser?Asn?Gly?Ala?Val?Lys

275

<210>20

<211>347

<212>PRT

＜213〉streptococcus pneumoniae

<400>20

Met?Lys?Ser?Ile?Leu?Gln?Lys?Met?Gly?Glu?His?Pro?Met?Leu?Leu?Leu

1 5 10 15

Phe?Leu?Ser?Tyr?Ser?Thr?Val?Ile?Ser?Ile?Leu?Ala?Gln?Asn?Trp?Met

20 25 30

Gly?Leu?Val?Ala?Ser?Val?Gly?Met?Phe?Leu?Phe?Thr?Ile?Phe?Phe?Leu

35 40 45

His?Tyr?Gln?Ser?Ile?Leu?Ser?His?Lys?Phe?Phe?Arg?Leu?Ile?Leu?Gln

50 55 60

Phe?Val?Leu?Phe?Gly?Ser?Val?Leu?Ser?Ala?Ala?Phe?Ala?Ser?Leu?Glu

65 70 75 80

His?Phe?Gln?Ile?Val?Lys?Lys?Phe?Asn?Tyr?Ala?Phe?Leu?Ser?Pro?Asn

85 90 95

Met?Gln?Val?Trp?His?Gln?Asn?Arg?Ala?Glu?Val?Thr?Phe?Phe?Asn?Pro

100 105 110

Asn?Tyr?Tyr?Gly?Ile?Ile?Cys?Cys?Phe?Cys?Ile?Met?Ile?Ala?Phe?Tyr

115 120 125

Leu?Phe?Thr?Thr?Thr?Lys?Leu?Asn?Trp?Leu?Lys?Val?Phe?Cys?Val?Ile

130 135 140

Ala?Gly?Phe?Val?Asn?Leu?Phe?Gly?Leu?Asn?Phe?Thr?Gln?Asn?Arg?Thr

145 150 155 160

Ala?Phe?Pro?Ala?Ile?Ile?Ala?Gly?Ala?Ile?Ile?Tyr?Leu?Phe?Thr?Thr

165 170 175

Ile?Lys?Asn?Trp?Lys?Ala?Phe?Trp?Leu?Ser?Ile?Gly?Val?Phe?Ala?Ile

180 185 190

Gly?Leu?Ser?Phe?Leu?Phe?Ser?Ser?Asp?Leu?Gly?Val?Arg?Met?Gly?Thr

195 200 205

Leu?Asp?Ser?Ser?Met?Glu?Glu?Arg?Ile?Ser?Ile?Trp?Asp?Ala?Gly?Met

210 215 220

Ala?Leu?Phe?Lys?Gln?Asn?Pro?Phe?Trp?Gly?Glu?Gly?Pro?Leu?Thr?Tyr

225 230 235 240

Met?Asn?Ser?Tyr?Pro?Arg?Ile?His?Ala?Pro?Tyr?His?Glu?His?Ala?His

245 250 255

Ser?Leu?Tyr?Ile?Asp?Thr?Ile?Leu?Ser?Tyr?Gly?Ile?Val?Gly?Thr?Ile

260 265 270

Leu?Leu?Val?Leu?Ser?Ser?Val?Ala?Pro?Val?Arg?Leu?Met?Met?Asp?Met

275 280 285

Ser?Gln?Glu?Ser?Gly?Lys?Arg?Pro?Ile?Ile?Gly?Leu?Tyr?Leu?Ser?Phe

290 295 300

Leu?Thr?Val?Val?Ala?Val?His?Gly?Ile?Phe?Asp?Leu?Ala?Leu?Phe?Trp

305 310 315 320

Ile?Gln?Ser?Gly?Phe?Ile?Phe?Leu?Leu?Val?Met?Cys?Ser?Ile?Pro?Leu

325 330 335

Glu?His?Arg?Met?Leu?Val?Ser?Asp?Met?Thr?Asp

340 345

<210>2l

<211>432

<212>PRT

＜213〉streptococcus pneumoniae

<400>21

Met?Ser?Lys?Met?Asp?Val?Gln?Lys?Ile?Ile?Ala?Pro?Met?Met?Lys?Phe

1 5 10 15

Val?Asn?Met?Arg?Gly?Ile?Ile?Ala?Leu?Lys?Asp?Gly?Met?Leu?Ala?Ile

20 25 30

Leu?Pro?Leu?Thr?Val?Val?Gly?Ser?Leu?Phe?Leu?Ile?Met?Gly?Gln?Leu

35 40 45

Pro?Phe?Glu?Gly?Leu?Asn?Lys?Ser?Ile?Ala?Ser?Val?Phe?Gly?Ala?Asn

50 55 60

Trp?Thr?Glu?Pro?Phe?Met?Gln?Val?Tyr?Ser?Gly?Thr?Phe?Ala?Ile?Met

65 70 75 80

Gly?Leu?Ile?Ser?Cys?Phe?Ser?Ile?Ala?Tyr?Ser?Tyr?Ala?Lys?Asn?Ser

85 90 95

Gly?Val?Glu?Ala?Leu?Pro?Ala?Gly?Val?Leu?Ser?Val?Ser?Ala?Phe?Phe

100 105 110

Ile?Leu?Leu?Arg?Ser?Ser?Tyr?Ile?Pro?Lys?Gln?Gly?Glu?Ala?Ile?Gly

115 120 125

Asp?Ala?Ile?Ser?Lys?Val?Trp?Phe?Gly?Gly?Gln?Gly?Ile?Ile?Gly?Ala

130 135 140

Ile?Ile?Ile?Gly?Leu?Val?Val?Gly?Ser?Ile?Tyr?Thr?Phe?Phe?Ile?Lys

145 150 155 160

Arg?Lys?Ile?Val?Ile?Lys?Met?Pro?Glu?Gln?Val?Pro?Gln?Ala?Ile?Ala

165 170 175

Lys?Gln?Phe?Glu?Ala?Met?Ile?Pro?Ala?Phe?Val?Ile?Phe?Leu?Ser?Ser

180 185 190

Met?Ile?Val?Tyr?Ile?Leu?Ala?Lys?Ser?Leu?Thr?Asn?Gly?Gly?Thr?Phe

195 200 205

Ile?Glu?Met?Ile?Tyr?Ser?Ala?Ile?Gln?Val?Pro?Leu?Gln?Gly?Leu?Thr

210 215 220

Gly?Ser?Leu?Tyr?Gly?Ala?Ile?Gly?Ile?Ala?Phe?Phe?Ile?Ser?Phe?Leu

225 230 235 240

Trp?Trp?Phe?Gly?Val?His?Gly?Gln?Ser?Val?Val?Asn?Gly?Val?Val?Thr

245 250 255

Ala?Leu?Leu?Leu?Ser?Asn?Leu?Asp?Ala?Asn?Lys?Ala?Met?Leu?Ala?Ser

260 265 270

Ala?Asn?Leu?Ser?Leu?Glu?Asn?Gly?Ala?His?Ile?Val?Thr?Gln?Gln?Phe

275 280 285

Leu?Asp?Ser?Phe?Leu?Ile?Leu?Ser?Gly?Ser?Gly?Ile?Thr?Phe?Gly?Leu

290 295 300

Val?Val?Ala?Met?Leu?Phe?Ala?Ala?Lys?Ser?Lys?Gln?Tyr?Gln?Ala?Leu

305 310 315 320

Gly?Lys?Val?Ala?Ala?Phe?Pro?Ala?Ile?Phe?Asn?Val?Asn?Glu?Pro?Val

325 330 335

Val?Phe?Gly?Phe?Pro?Ile?Val?Met?Asn?Pro?Val?Met?Phe?Val?Pro?Phe

340 345 350

Ile?Leu?Val?Pro?Val?Leu?Ala?Ala?Val?Ile?Val?Tyr?Gly?Ala?Ile?Ala

355 360 365

Thr?Gly?Phe?Met?Gln?Pro?Phe?Ser?Gly?Val?Thr?Leu?Pro?Trp?Ser?Thr

370 375 380

Pro?Ala?Ile?Leu?Ser?Gly?Phe?Leu?Val?Gly?Gly?Trp?Gln?Gly?Val?Ile

385 390 395 400

Thr?Gln?Leu?Val?Ile?Leu?Ala?Met?Ser?Thr?Leu?Val?Tyr?Phe?Pro?Phe

405 410 415

Phe?Lys?Val?Gln?Asp?Arg?Leu?Ala?Tyr?Gln?Asn?Glu?Ile?Lys?Gln?Ser

420 425 430

<210>22

<211>100

<212>PRT

＜213〉streptococcus pneumoniae

<400>22

Met?Lys?Lys?Lys?Asp?Leu?Val?Asp?Gln?Leu?Val?Ser?Glu?Ile?Glu?Thr

1 5 10 15

Gly?Lys?Val?Arg?Thr?Leu?Gly?Ile?Tyr?Gly?His?Gly?Ala?Ser?Gly?Lys

20 25 30

Ser?Thr?Phe?Ala?Gln?Glu?Leu?Tyr?Gln?Ala?Leu?Asp?Ser?Thr?Thr?Val

35 40 45

Asn?Leu?Leu?Glu?Thr?Asp?Pro?Tyr?Ile?Thr?Ser?Gly?Arg?His?Leu?Val

50 55 60

Val?Pro?Lys?Asp?Ala?Pro?Asn?Gln?Lys?Val?Thr?Ala?Ser?Leu?Pro?Val

65 70 75 80

Ala?His?Glu?Leu?Glu?Ser?Leu?Gln?Arg?Asp?Ile?Leu?Ala?Cys?Arg?Arg

85 90 95

Val?Trp?Met?Ser

100

<210>23

<211>238

<212>PRT

＜213〉streptococcus pneumoniae

<400>23

Met?Lys?Lys?Arg?Tyr?Leu?Val?Leu?Thr?Ala?Leu?Leu?Ala?Leu?Ser?Leu

1 5 10 15

Ala?Ala?Cys?Ser?Gln?Glu?Lys?Thr?Lys?Asn?Glu?Asp?Gly?Glu?Thr?Lys

20 25 30

Thr?Glu?Gln?Thr?Ala?Lys?Ala?Asp?Gly?Thr?Val?Gly?Ser?Lys?Ser?Gln

35 40 45

Gly?Ala?Ala?Gln?Lys?Lys?Ala?Glu?Val?Val?Asn?Lys?Gly?Asp?Tyr?Tyr

50 55 60

Ser?Ile?Gln?Gly?Lys?Tyr?Asp?Glu?Ile?Ile?Val?Ala?Asn?Lys?His?Tyr

65 70 75 80

Pro?Leu?Ser?Lys?Asp?Tyr?Asn?Pro?Gly?Glu?Asn?Pro?Thr?Ala?Lys?Ala

85 90 95

Glu?Leu?Val?Lys?Leu?Ile?Lys?Ala?Met?Gln?Glu?Ala?Gly?Phe?Pro?Ile

100 105 110

Ser?Asp?His?Tyr?Ser?Gly?Phe?Arg?Ser?Tyr?Glu?Thr?Gln?Thr?Lys?Leu

115 120 125

Tyr?Gln?Asp?Tyr?Val?Asn?Gln?Asp?Gly?Lys?Ala?Ala?Ala?Asp?Arg?Tyr

130 135 140

Ser?Ala?Arg?Pro?Gly?Tyr?Ser?Glu?His?Gln?Thr?Gly?Leu?Ala?Phe?Asp

145 150 155 160

Val?Ile?Gly?Thr?Asp?Gly?Asp?Leu?Val?Thr?Glu?Glu?Lys?Ala?Ala?Gln

165 170 175

Trp?Leu?Leu?Asp?His?Ala?Ala?Asp?Tyr?Gly?Phe?Val?Val?Arg?Tyr?Leu

180 185 190

Lys?Gly?Lys?Glu?Lys?Glu?Thr?Gly?Tyr?Met?Ala?Glu?Glu?Trp?His?Leu

195 200 205

Arg?Tyr?Val?Gly?Lys?Glu?Ala?Lys?Glu?Ile?Ala?Ala?Ser?Gly?Leu?Ser

210 215 220

Leu?Glu?Glu?Tyr?Tyr?Gly?Phe?Glu?Gly?Gly?Asp?Tyr?Val?Asp

225 230 235

<210>24

<211>425

<212>PRT

＜213〉streptococcus pneumoniae

<400>24

Met?Arg?Glu?Pro?Asp?Phe?Leu?Asn?His?Phe?Leu?Lys?Lys?Gly?Tyr?Phe

1 5 10 15

Lys?Lys?His?Ala?Lys?Ala?Val?Leu?Ala?Leu?Ser?Gly?Gly?Leu?Asp?Ser

20 25 30

Met?Phe?Leu?Phe?Lys?Val?Leu?Ser?Thr?Tyr?Gln?Lys?Glu?Leu?Glu?Ile

35 40 45

Glu?Leu?Ile?Leu?Ala?His?Val?Asn?His?Lys?Gln?Arg?Ile?Glu?Ser?Asp

50 55 60

Trp?Glu?Glu?Lys?Glu?Leu?Arg?Lys?Leu?Ala?Ala?Glu?Ala?Glu?Leu?Pro

65 70 75 80

Ile?Tyr?Ile?Ser?Asn?Phe?Ser?Gly?Glu?Phe?Ser?Glu?Ala?Arg?Ala?Arg

85 90 95

Asn?Phe?Arg?Tyr?Asp?Phe?Phe?Gln?Glu?Val?Met?Lys?Lys?Thr?Gly?Ala

100 105 110

Thr?Ala?Leu?Val?Thr?Ala?His?His?Ala?Asp?Asp?Gln?Val?Glu?Thr?Ile

115 120 125

Phe?Met?Arg?Leu?Ile?Arg?Gly?Thr?Arg?Leu?Arg?Tyr?Leu?Ser?Gly?Ile

130 135 140

Lys?Glu?Lys?Gln?Val?Val?Gly?Glu?Ile?Glu?Ile?Ile?Arg?Pro?Phe?Leu

145 150 155 160

His?Phe?Gln?Lys?Lys?Asp?Phe?Pro?Ser?Ile?Phe?His?Phe?Glu?Asp?Thr

165 170 175

Ser?Asn?Gln?Glu?Asn?His?Tyr?Phe?Arg?Asn?Arg?Ile?Arg?Asn?Ser?Tyr

180 185 190

Leu?Pro?Glu?Leu?Glu?Lys?Glu?Asn?Pro?Arg?Phe?Arg?Asp?Ala?Ile?Leu

195 200 205

Gly?Ile?Gly?Asn?Glu?Ile?Leu?Asp?Tyr?Asp?Leu?Ala?Ile?Ala?Glu?Leu

210 215 220

Ser?Asn?Asn?Ile?Asn?Val?Glu?Asp?Leu?Gln?Gln?Leu?Phe?Ser?Tyr?Ser

225 230 235 240

Glu?Ser?Thr?Gln?Arg?Val?Leu?Leu?Gln?Thr?Tyr?Leu?Asn?Arg?Phe?Pro

245 250 255

Asp?Leu?Asn?Leu?Thr?Lys?Ala?Gln?Phe?Ala?Glu?Val?Gln?Gln?Ile?Leu

260 265 270

Lys?Ser?Lys?Ser?Gln?Tyr?Arg?His?Pro?Ile?Lys?Asn?Gly?Tyr?Glu?Leu

275 280 285

Ile?Lys?Glu?Tyr?Gln?Gln?Phe?Gln?Ile?Cys?Lys?Ile?Ser?Pro?Gln?Ala

290 295 300

Asp?Glu?Lys?Glu?Asp?Glu?Leu?Val?Leu?His?Tyr?Gln?Asn?Gln?Val?Ala

305 310 315 320

Tyr?Gln?Gly?Tyr?Leu?Phe?Ser?Phe?Gly?Leu?Pro?Leu?Glu?Gly?Glu?Leu

325 330 335

Ile?Gln?Gln?Ile?Pro?Val?Ser?Arg?Glu?Thr?Ser?Ile?His?Ile?Arg?His

340 345 350

Arg?Lys?Thr?Gly?Asp?Val?Leu?Ile?Lys?Asn?Gly?His?Arg?Lys?Lys?Leu

355 360 365

Arg?Arg?Leu?Phe?Ile?Asp?Leu?LysIle?Pro?Met?Glu?Lys?Arg?Asn?Ser

370 375 380

Ala?Leu?Ile?Ile?Glu?Gln?Phe?Gly?Glu?Ile?Val?Ser?Ile?Leu?Gly?Ile

385 390 395 400

Ala?Thr?Asn?Asn?Leu?Ser?Lys?Lys?Thr?Lys?Asn?Asp?Ile?Met?Asn?Thr

405 410 415

Val?Leu?Tyr?Ile?Glu?Lys?Ile?Asp?Arg

420 425

<210>25

<211>422

<212>PRT

＜213〉streptococcus pneumoniae

<400>25

Met?Arg?Lys?Phe?Leu?Ile?Ile?Leu?Leu?Leu?Pro?Ser?Phe?Leu?Thr?Ile

1 5 10 15

Ser?Lys?Val?Val?Ser?Thr?Glu?Lys?Glu?Val?Val?Tyr?Thr?Ser?Lys?Glu

20 25 30

Ile?Tyr?Tyr?Leu?Ser?Gln?Ser?Asp?Phe?Gly?Ile?Tyr?Phe?Arg?Glu?Lys

35 40 45

Leu?Ser?Ser?Pro?Met?Val?Tyr?Gly?Glu?Val?Pro?Val?Tyr?Ala?Asn?Glu

50 55 60

Asp?Leu?Val?Val?Glu?Ser?Gly?Lys?Leu?Thr?Pro?Lys?Thr?Ser?Phe?Gln

65 70 75 80

Ile?Thr?Glu?Trp?Arg?Leu?Asn?Lys?Gln?Gly?Ile?Pro?Val?Phe?Lys?Leu

85 90 95

Ser?Asn?His?Gln?Phe?Ile?Ala?Ala?Asp?Lys?Arg?Phe?Leu?Tyr?Asp?Gln

100 105 110

Ser?Glu?Val?Thr?Pro?Thr?Ile?Lys?Lys?Val?Trp?Leu?Glu?Ser?Asp?Phe

115 120 125

Lys?Leu?Tyr?Asn?Ser?Pro?Tyr?Asp?Leu?Lys?Glu?Val?Lys?Ser?Ser?Leu

130 135 140

Ser?Ala?Tyr?Ser?Gln?Val?Ser?Ile?Asp?Lys?Thr?Met?Phe?Val?Glu?Gly

145 150 155 160

Arg?Glu?Phe?Leu?His?Ile?Asp?Gln?Ala?Gly?Trp?Val?Ala?Lys?Glu?Ser

165 170 175

Thr?Ser?Glu?Glu?Asp?Asn?Arg?Met?Ser?Lys?Val?Gln?Glu?Met?Leu?Ser

180 185 190

Glu?Lys?Tyr?Gln?Lys?Asp?Ser?Phe?Ser?Ile?Tyr?Val?Lys?Gln?Leu?Thr

195 200 205

Thr?Gly?Lys?Glu?Ala?Gly?Ile?Asn?Gln?Asp?Glu?Lys?Met?Tyr?Ala?Ala

210 215 220

Ser?Val?Leu?Lys?Leu?Ser?Tyr?Leu?Tyr?Tyr?Thr?Gln?Glu?Lys?Ile?Asn

225 230 235 240

Glu?Gly?Leu?Tyr?Gln?Leu?Asp?Thr?Thr?Val?Lys?Tyr?Val?Ser?Ala?Val

245 250 255

Asn?Asp?Phe?Pro?Gly?Ser?Tyr?Lys?Pro?Glu?Gly?Ser?Gly?Ser?Leu?Pro

260 265 270

Lys?Lys?Glu?Asp?Asn?Lys?Glu?Tyr?Ser?Leu?Lys?Asp?Leu?Ile?Thr?Lys

275 280 285

Val?Ser?Lys?Glu?Ser?Asp?Asn?Val?Ala?His?Asn?Leu?Leu?Gly?Tyr?Tyr

290 295 300

Ile?Ser?Asn?Gln?Ser?Asp?Ala?Thr?Phe?Lys?Ser?Lys?Met?Ser?Ala?Ile

305 310 315 320

Met?Gly?Asp?Asp?Trp?Asp?Pro?Lys?Glu?Lys?Leu?Ile?Ser?Ser?Lys?Met

325 330 335

Ala?Gly?Lys?Phe?Met?Glu?Ala?Ile?Tyr?Asn?Gln?Asn?Gly?Phe?Val?Leu

340 345 350

Glu?Ser?Leu?Thr?Lys?Thr?Asp?Phe?Asp?Ser?Gln?Arg?Ile?Ala?Lys?Gly

355 360 365

Val?Ser?Val?Lys?Val?Ala?His?Lys?Ile?Gly?Asp?Ala?Asp?Glu?Phe?Lys

370 375 380

His?Asp?Thr?Gly?Val?Val?Tyr?Ala?Asp?Ser?Pro?Phe?Ile?Leu?Ser?Ile

385 390 395 400

Phe?Thr?Lys?Asn?Ser?Asp?Tyr?Asp?Thr?Ile?Ser?Lys?Ile?Ala?Lys?Asp

405 410 415

Val?Tyr?Glu?Val?Leu?Lys

420

<210>26

<211>652

<212>PRT

＜213〉streptococcus pneumoniae

<400>26

Met?Lys?Lys?Gln?Asn?Asn?Gly?Leu?Ile?Lys?Asn?Pro?Phe?Leu?Trp?Leu

1 5 10 15

Leu?Phe?Ile?Phe?Phe?Leu?Val?Thr?Gly?Phe?Gln?Tyr?Phe?Tyr?Ser?Gly

20 25 30

Asn?Asn?Ser?Gly?Gly?Ser?Gln?Gln?Ile?Asn?Tyr?Thr?Glu?Leu?Val?Gln

35 40 45

Glu?Ile?Thr?Asp?Gly?Asn?Val?Lys?Glu?Leu?Thr?Tyr?Gln?Pro?Asn?Gly

50 55 60

Ser?Val?Ile?Glu?Val?Ser?Gly?Val?Tyr?Lys?Asn?Pro?Lys?Thr?Ser?Lys

65 70 75 80

Glu?Glu?Thr?Gly?Ile?Gln?Phe?Phe?Thr?Pro?Ser?Val?Thr?Lys?Val?Glu

85 90 95

Lys?Phe?Thr?Ser?Thr?Ile?Leu?Pro?Ala?Asp?Thr?Thr?Val?Ser?Glu?Leu

100 105 110

Gln?Lys?Leu?Ala?Thr?Asp?His?Lys?Ala?Glu?Val?Thr?Val?Lys?His?Glu

115 120 125

Ser?Ser?Ser?Gly?Ile?Trp?Ile?Asn?Leu?Leu?Val?Ser?Ile?Val?Pro?Phe

130 135 140

Gly?Ile?Leu?Phe?Phe?Phe?Leu?Phe?Ser?Met?Met?Gly?Asn?Met?Gly?Gly

145 150 155 160

Gly?Asn?Gly?Arg?Asn?Pro?Met?Ser?Phe?Gly?Arg?Ser?Lys?Ala?Lys?Ala

165 170 175

Ala?Asn?Lys?Glu?Asp?Ile?Lys?Val?Arg?Phe?Ser?Asp?Val?Ala?Gly?Ala

180 185 190

Glu?Glu?Glu?Lys?Gln?Glu?Leu?Val?Glu?Val?Val?Glu?Phe?Leu?Lys?Asp

195 200 205

Pro?Lys?Arg?Phe?Thr?Lys?Leu?Gly?Ala?Arg?Ile?Pro?Ala?Gly?Val?Leu

210 215 220

Leu?Glu?Gly?Pro?Pro?Gly?Thr?Gly?Lys?Thr?Leu?Leu?Ala?Lys?Ala?Val

225 230 235 240

Ala?Gly?Glu?Ala?Gly?Val?Pro?Phe?Phe?Ser?Ile?Ser?Gly?Ser?Asp?Phe

245 250 255

Val?Glu?Met?Phe?Val?Gly?Val?Gly?Ala?Ser?Arg?Val?Arg?Ser?Leu?Phe

260 265 270

Glu?Asp?Ala?Lys?Lys?Ala?Ala?Pro?Ala?Ile?Ile?Phe?Ile?Asp?Glu?Ile

275 280 285

Asp?Ala?Val?Gly?Arg?Gln?Arg?Gly?Val?Gly?Leu?Gly?Gly?Gly?Asn?Asp

290 295 300

Glu?Arg?Glu?Gln?Thr?Leu?Asn?Gln?Leu?Leu?Ile?Glu?Met?Asp?Gly?Phe

305 310 315 320

Glu?Gly?Asn?Glu?Gly?Ile?Ile?Val?Ile?Ala?Ala?Thr?Asn?Arg?Ser?Asp

325 330 335

Val?Leu?Asp?Pro?Ala?Leu?Leu?Arg?Pro?Gly?Arg?Phe?Asp?Arg?Lys?Val

340 345 350

Leu?Val?Gly?Arg?Pro?Asp?Val?Lys?Gly?Arg?Glu?Ala?Ile?Leu?Lys?Val

355 360 365

His?Ala?Lys?Asn?Lys?Pro?Leu?Ala?Glu?Asp?Val?Asp?Leu?Lys?Leu?Val

370 375 380

Ala?Gln?Gln?Thr?Pro?Gly?Phe?Val?Gly?Ala?Asp?Leu?Glu?Asn?Val?Leu

385 390 395 400

Asn?Glu?Ala?Ala?Leu?Val?Ala?Ala?Arg?Arg?Asn?Lys?Ser?Ile?Ile?Asp

405 410 415

Ala?Ser?Asp?Ile?Asp?Glu?Ala?Glu?Asp?Arg?Val?Ile?Ala?Gly?Pro?Ser

420 425 430

Lys?Lys?Asp?Lys?Thr?Val?Ser?Gln?Lys?Glu?Arg?Glu?Leu?Val?Ala?Tyr

435 440 445

His?Glu?Ala?Gly?His?Thr?Ile?Val?Gly?Leu?Val?Leu?Ser?Asn?Ala?Arg

450 455 460

Val?Val?His?Lys?Val?Thr?Ile?Val?Pro?Arg?Gly?Arg?Ala?Gly?Gly?Tyr

465 470 475 480

Met?Ile?Ala?Leu?Pro?Lys?Glu?Asp?Gln?Met?Leu?Leu?Ser?Lys?Glu?Asp

485 490 495

Met?Lys?Glu?Gln?Leu?Ala?Gly?Leu?Met?Gly?Gly?Arg?Val?Ala?Glu?Glu

500 505 510

Ile?Ile?Phe?Asn?Val?Gln?Thr?Thr?Gly?Ala?Ser?Asn?Asp?Phe?Glu?Gln

515 520 525

Ala?Thr?Gln?Met?Ala?Arg?Ala?Met?Val?Thr?Glu?Tyr?Gly?Met?Ser?Glu

530 535 540

Lys?Leu?Gly?Pro?Val?Gln?Tyr?Glu?Gly?Asn?His?Ala?Met?Leu?Gly?Ala

545 550 555 560

Gln?Ser?Pro?Gln?Lys?Ser?Ile?Ser?Glu?Gln?Thr?Ala?Tyr?Glu?Ile?Asp

565 570 575

Glu?Glu?Val?Arg?Ser?Leu?Leu?Asn?Glu?Ala?Arg?Asn?Lys?Ala?Ala?Glu

580 585 590

Ile?Ile?Gln?Ser?Asn?Arg?Glu?Thr?His?Lys?Leu?Ile?Ala?Glu?Ala?Leu

595 600 605

Leu?Lys?Tyr?Glu?Thr?Leu?Asp?Ser?Thr?Gln?Ile?Lys?Ala?Leu?Tyr?Glu

610 615 620

Thr?Gly?Lys?Met?Pro?Glu?Ala?Val?Glu?Glu?Glu?Ser?His?Ala?Leu?Ser

625 630 635 640

Tyr?Asp?Glu?Val?Lys?Ser?Lys?Met?Asn?Asp?Glu?Lys

645 650

<210>27

<211>563

<212>PRT

＜213〉streptococcus pneumoniae

<400>27

Met?Lys?Arg?Ser?Ser?Leu?Leu?Val?Arg?Met?Val?Ile?Ser?Ile?Phe?Leu

1 5 10 15

Val?Phe?Leu?Ile?Leu?Leu?Ala?Leu?Val?Gly?Thr?Phe?Tyr?Tyr?Gln?Ser

20 25 30

Ser?Ser?Ser?Ala?Ile?Glu?Ala?Thr?Ile?Glu?Gly?Asn?Ser?Gln?Thr?Thr

35 40 45

Ile?Ser?Gln?Thr?Ser?His?Phe?Ile?Gln?Ser?Tyr?Ile?Lys?Lys?Leu?Glu

50 55 60

Thr?Thr?Ser?Thr?Gly?Leu?Thr?Gln?Gln?Thr?Asp?Val?Leu?Ala?Tyr?Ala

65 70 75 80

Glu?Asn?Pro?Ser?Gln?Asp?Lys?Val?Glu?Gly?Ile?Arg?Asp?Leu?Phe?Leu

85 90 95

Thr?Ile?Leu?Lys?Ser?Asp?Lys?Asp?Leu?Lys?Thr?Val?Val?Leu?Val?Thr

100 105 110

Lys?Ser?Gly?Gln?Val?Ile?Ser?Thr?Asp?Asp?Ser?Val?Gln?Met?Lys?Thr

115 120 125

Ser?Ser?Asp?Met?Met?Ala?Glu?Asp?Trp?Tyr?Gln?Lys?Ala?Ile?His?Gln

130 135 140

Gly?Ala?Met?Pro?Val?Leu?Thr?Pro?Ala?Arg?Lys?Ser?Asp?Ser?Gln?Trp

145 150 155 160

Val?Ile?Ser?Val?Thr?Gln?Glu?Leu?Val?Asp?Ala?Lys?Gly?Ala?Asn?Leu

165 170 175

Gly?Val?Leu?Arg?Leu?Asp?Ile?Ser?Tyr?Glu?Thr?Leu?Glu?Ala?Tyr?Leu

180 185 190

Asn?Gln?Leu?Gln?Leu?Gly?Gln?Gln?Gly?Phe?Ala?Phe?Ile?Ile?Asn?Glu

195 200 205

Asn?His?Glu?Phe?Val?Tyr?His?Pro?Gln?His?Thr?Val?Tyr?Ser?Ser?Ser

210 215 220

Ser?Lys?Met?Glu?Ala?Met?Lys?Pro?Tyr?Ile?Asp?Thr?Gly?Gln?Gly?Tyr

225 230 235 240

Thr?Pro?Gly?His?Lys?Ser?Tyr?Val?Ser?Gln?Glu?Lys?Ile?Ala?Gly?Thr

245 250 255

Asp?Trp?Thr?Val?Leu?Gly?Val?Ser?Ser?Leu?Glu?Lys?Leu?Asp?Gln?Val

260 265 270

Arg?Ser?Gln?Leu?Leu?Trp?Thr?Leu?Leu?Gly?Ala?Ser?Val?Thr?Ser?Leu

275 280 285

Leu?Val?Cys?Leu?Cys?Leu?Val?Trp?Phe?Ser?Leu?Lys?Arg?Trp?Ile?Ala

290 295 300

Pro?Leu?Lys?Asp?Leu?Arg?Glu?Thr?Met?Leu?Glu?Ile?Ala?Ser?Gly?Ala

305 310 315 320

Gln?Asn?Leu?Arg?Ala?Lys?Glu?Val?Gly?Ala?Tyr?Glu?Leu?Arg?Glu?Val

325 330 335

Thr?Arg?Gln?Phe?Asn?Ala?Met?Leu?Asp?Gln?Ile?Asp?Gln?Leu?Met?Val

340 345 350

Ala?Ile?Arg?Ser?Gln?Glu?Glu?Thr?Thr?Arg?Gln?Tyr?Gln?Leu?Gln?Ala

355 360 365

Leu?Ser?Ser?Gln?Ile?Asn?Pro?His?Phe?Leu?Tyr?Asn?Thr?Leu?Asp?Thr

370 375 380

Ile?Ile?Trp?Met?Ala?Glu?Phe?His?Asp?Ser?Gln?Arg?Val?Val?Gln?Val

385 390 395 400

Thr?Lys?Ser?Leu?Ala?Thr?Tyr?Phe?Arg?Leu?Ala?Leu?Asn?Gln?Gly?Lys

405 410 415

Asp?Leu?Ile?Cys?Leu?Ser?Asp?Glu?Ile?Asn?His?Val?Arg?Gln?Tyr?Leu

420 425 430

Phe?Ile?Gln?Lys?Gln?Arg?Tyr?Gly?Asp?Lys?Leu?Glu?Tyr?Glu?Ile?Asn

435 440 445

Glu?Asn?Val?Ala?Phe?Asp?Asn?Leu?Val?Leu?Pro?Lys?Leu?Val?Leu?Gln

450 455 460

Pro?Leu?Val?Glu?Asn?Ala?Leu?Tyr?His?Gly?Ile?Lys?Glu?Lys?Glu?Gly

465 470 475 480

Gln?Gly?His?Ile?Lys?Leu?Ser?Val?Gln?Lys?Gln?Asp?Ser?Gly?Leu?Val

485 490 495

Ile?Arg?Ile?Glu?Asp?Asp?Gly?Val?Gly?Phe?Gln?Asp?Ala?Gly?Asp?Ser

500 505 510

Ser?Gln?Ser?Gln?Leu?Lys?Arg?Gly?Gly?Val?Gly?Leu?Gln?Asn?Val?Asp

515 520 525

Gln?Arg?Leu?Lys?Leu?His?Phe?Gly?Ala?Asn?Tyr?His?Met?Lys?Ile?Asp

530 535 540

Ser?Arg?Pro?Gln?Lys?Gly?Thr?Lys?Val?Glu?Ile?Tyr?Ile?Asn?Arg?Ile

545 550 555 560

Glu?Thr?Ser

<210>28

<211>563

<212>PRT

＜213〉streptococcus pneumoniae

<400>28

Met?Lys?Arg?Ser?Ser?Leu?Leu?Val?Arg?Met?Val?Ile?Ser?Ile?Phe?Leu

1 5 10 15

Val?Phe?Leu?Ile?Leu?Leu?Ala?Leu?Val?Gly?Thr?Phe?Tyr?Tyr?Gln?Ser

20 25 30

Ser?Ser?Ser?Ala?Ile?Glu?Ala?Thr?Ile?Glu?Gly?Asn?Ser?Gln?Thr?Thr

35 40 45

Ile?Ser?Gln?Thr?Ser?His?Phe?Ile?Gln?Ser?Tyr?Ile?Lys?Lys?Leu?Glu

50 55 60

Thr?Thr?Ser?Thr?Gly?Leu?Thr?Gln?Gln?Thr?Asp?Val?Leu?Ala?Tyr?Ala

65 70 75 80

Glu?Asn?Pro?Ser?Gln?Asp?Lys?Val?Glu?Gly?Ile?Arg?Asp?Leu?Phe?Leu

85 90 95

Thr?Ile?Leu?Lys?Ser?Asp?Lys?Asp?Leu?Lys?Thr?Val?Val?Leu?Val?Thr

100 105 110

Lys?Ser?Gly?Gln?Val?Ile?Ser?Thr?Asp?Asp?Ser?Val?Gln?Met?Lys?Thr

115 120 125

Ser?Ser?Asp?Met?Met?Ala?Glu?Asp?Trp?Tyr?Gln?Lys?Ala?Ile?His?Gln

130 135 140

GlyAla?Met?Pro?Val?Leu?Thr?Pro?Ala?Arg?Lys?Ser?Asp?Ser?Gln?Trp

145 150 155 160

Val?Ile?Ser?Val?Thr?Gln?Glu?Leu?Val?Asp?Ala?Lys?Gly?Ala?Asn?Leu

165 170 175

Gly?Val?Leu?Arg?Leu?Asp?Ile?Ser?Tyr?Glu?Thr?Leu?Glu?Ala?Tyr?Leu

180 185 190

Asn?Gln?Leu?Gln?Leu?Gly?Gln?Gln?Gly?Phe?Ala?Phe?Ile?Ile?Asn?Glu

195 200 205

Asn?His?Glu?Phe?Val?Tyr?His?Pro?Gln?His?Thr?Val?Tyr?Ser?Ser?Ser

210 215 220

Ser?Lys?Met?Glu?Ala?Met?Lys?Pro?Tyr?Ile?Asp?Thr?Gly?Gln?Gly?Tyr

225 230 235 240

Thr?Pro?Gly?His?Lys?Ser?Tyr?Val?Ser?Gln?Glu?Lys?Ile?Ala?Gly?Thr

245 250 255

Asp?Trp?Thr?Val?Leu?Gly?Val?Ser?Ser?Leu?Glu?Lys?Leu?Asp?Gln?Val

260 265 270

Arg?Ser?Gln?Leu?Leu?Trp?Thr?Leu?Leu?Gly?Ala?Ser?Val?Thr?Ser?Leu

275 280 285

Leu?Val?Cys?Leu?Cys?Leu?Val?Trp?Phe?Ser?Leu?Lys?Arg?Trp?Ile?Ala

290 295 300

Pro?Leu?Lys?Asp?Leu?Arg?Glu?Thr?Met?Leu?Glu?Ile?Ala?Ser?Gly?Ala

305 310 315 320

Gln?Asn?Leu?Arg?Ala?Lys?Glu?Val?Gly?Ala?Tyr?Glu?Leu?Arg?Glu?Val

325 330 335

Thr?Arg?Gln?Phe?Asn?Ala?Met?Leu?Asp?Gln?Ile?Asp?Gln?Leu?Met?Val

340 345 350

Ala?Ile?Arg?Ser?Gln?Glu?Glu?Thr?Thr?Arg?Gln?Tyr?Gln?Leu?Gln?Ala

355 360 365

Leu?Ser?Ser?Gln?Ile?Asn?Pro?His?Phe?Leu?Tyr?Asn?Thr?Leu?Asp?Thr

370 375 380

Ile?Ile?Trp?Met?Ala?Glu?Phe?His?Asp?Ser?Gln?Arg?Val?Val?Gln?Val

385 390 395 400

Thr?Lys?Ser?Leu?Ala?Thr?Tyr?Phe?Arg?Leu?Ala?Leu?Asn?Gln?Gly?Lys

405 410 415

Asp?Leu?Ile?Cys?Leu?Ser?Asp?Glu?Ile?Asn?His?Val?Arg?Gln?Tyr?Leu

420 425 430

Phe?Ile?Gln?Lys?Gln?Arg?Tyr?Gly?Asp?Lys?Leu?Glu?Tyr?Glu?Ile?Asn

435 440 445

Glu?Asn?Val?Ala?Phe?Asp?Asn?Leu?Val?Leu?Pro?Lys?Leu?Val?Leu?Gln

450 455 460

Pro?Leu?Val?Glu?Asn?Ala?Leu?Tyr?His?Gly?Ile?Lys?Glu?Lys?Glu?Gly

465 470 475 480

Gln?Gly?His?Ile?Lys?Leu?Ser?Val?Gln?Lys?Gln?Asp?Ser?Gly?Leu?Val

485 490 495

Ile?Arg?Ile?Glu?Asp?Asp?Gly?Val?Gly?Phe?Gln?Asp?Ala?Gly?Asp?Ser

500 505 510

Ser?Gln?Ser?Gln?Leu?Lys?Arg?Gly?Gly?Val?Gly?Leu?Gln?Asn?Val?Asp

515 520 525

Gln?Arg?Leu?Lys?Leu?His?Phe?Gly?Ala?Asn?Tyr?His?Met?Lys?Ile?Asp

530 535 540

Ser?Arg?Pro?Gln?Lys?Gly?Thr?Lys?Val?Glu?Ile?Tyr?Ile?Asn?Arg?Ile

545 550 555 560

Glu?Thr?Ser

<210>29

<211>379

<212>PRT

＜213〉streptococcus pneumoniae

<400>29

Met?Phe?Phe?Lys?Leu?Leu?Arg?Glu?Ala?Leu?Lys?Val?Lys?Gln?Val?Arg

1 5 10 15

Ser?Lys?Ile?Leu?Phe?Thr?Ile?Phe?Ile?Val?Leu?Val?Phe?Arg?Ile?Gly

20 25 30

Thr?Ser?Ile?Thr?Val?Pro?Gly?Val?Asn?Ala?Asn?Ser?Leu?Asn?Ala?Leu

35 40 45

Ser?Gly?Leu?Ser?Phe?Leu?Asn?Met?Leu?Ser?Leu?Val?Ser?Gly?Asn?Ala

50 55 60

Leu?Lys?Asn?Phe?Ser?Ile?Phe?Ala?Leu?Gly?Val?Ser?Pro?Tyr?Ile?Thr

65 70 75 80

Ala?Ser?Ile?Val?Val?Gln?Leu?Leu?Gln?Met?Asp?Ile?Leu?Pro?Lys?Phe

85 90 95

Val?Glu?Trp?Gly?Lys?Gln?Gly?Glu?Val?Gly?Arg?Arg?Lys?Leu?Asn?Gln

100 105 110

Ala?Thr?Arg?Tyr?Ile?Ala?Leu?Val?Leu?Ala?Phe?Val?Gln?Ser?Ile?Gly

115 120 125

Ile?Thr?Ala?Gly?Phe?Asn?Thr?Leu?Ala?Gly?Ala?Gln?Leu?Ile?Lys?Thr

130 135 140

Ala?Leu?Thr?Pro?Gln?Val?Phe?Leu?Thr?Ile?Gly?Ile?Ile?Leu?Thr?Ala

145 150 155 160

Gly?Ser?Met?Ile?Val?Thr?Trp?Leu?Gly?Glu?Gln?Ile?Thr?Asp?Lys?Gly

165 170 175

Tyr?Gly?Asn?Gly?Val?Ser?Met?Ile?Ile?Phe?Ala?Gly?Ile?Val?Ser?Ser

180 185 190

Ile?Pro?Glu?Met?Ile?Gln?Gly?Ile?Tyr?Val?Asp?Tyr?Phe?Val?Asn?Val

195 200 205

Pro?Ser?Ser?Arg?Ile?Thr?Ser?Ser?Ile?Ile?Phe?Val?Ile?Ile?Leu?Ile

210 215 220

Ile?Thr?Val?Leu?Leu?Ile?Ile?Tyr?Phe?Thr?Thr?Tyr?Val?Gln?Gln?Ala

225 230 235 240

Glu?Tyr?Lys?Ile?Pro?Ile?Gln?Tyr?Thr?Lys?Val?Ala?Gln?Gly?Ala?Pro

245 250 255

Ser?Ser?Ser?Tyr?Leu?Pro?Leu?Lys?Val?Asn?Pro?Ala?Gly?Val?Ile?Pro

260 265 270

Val?Ile?Phe?Ala?Ser?Ser?Ile?Thr?Ala?Ala?Pro?Ala?Ala?Ile?Leu?Gln

275 280 285

Phe?Leu?Ser?Ala?Thr?Gly?His?Asp?Trp?Ala?Trp?Val?Arg?Val?Ala?Gln

290 295 300

Glu?Met?Leu?Ala?Thr?Thr?Ser?Pro?Thr?Gly?Ile?Ala?Met?Tyr?Ala?Leu

305 310 315 320

Leu?Ile?Ile?Leu?Phe?Thr?Phe?Phe?Tyr?Thr?Phe?Val?Gln?Ile?Asn?Pro

325 330 335

Glu?Lys?Ala?Ala?Glu?Thr?Tyr?Lys?Arg?Val?Val?Pro?Ile?Ser?Met?Glu

340 345 350

Phe?Val?Leu?Val?Lys?Val?Gln?Lys?Asn?Ile?Cys?Leu?Asn?Phe?Phe?Val

355 360 365

Val?Leu?Gln?Leu?Leu?Val?Pro?Ser?Ser?Leu?Val

370 375

<210>30

<211>445

<212>PRT

＜213〉streptococcus pneumoniae

<400>30

Met?Asp?Ile?Arg?Gln?Val?Thr?Glu?Thr?Ile?Ala?Met?Ile?Glu?Glu?Gln

1 5 10 15

Asn?Phe?Asp?Ile?Arg?Thr?Ile?Thr?Met?Gly?Ile?Ser?Leu?Leu?Asp?Cys

20 25 30

Ile?Asp?Pro?Asp?Ile?Asn?Arg?Ala?Ala?Glu?Lys?Ile?Tyr?Gln?Lys?Ile

35 40 45

Thr?Thr?Lys?Ala?Ala?Asn?Leu?Val?Ala?Val?Gly?Asp?Glu?Ile?Ala?Ala

50 55 60

Glu?Leu?Gly?Ile?Pro?Ile?Val?Asn?Lys?Arg?Val?Ser?Val?Thr?Pro?Ile

65 70 75 80

Ser?Leu?Ile?Gly?Ala?Ala?Thr?Asp?Ala?Thr?Asp?Tyr?Val?Val?Leu?Ala

85 90 95

Lys?Ala?Leu?Asp?Lys?Ala?Ala?Lys?Glu?Ile?Gly?Val?Asp?Phe?Ile?Gly

100 105 110

Gly?Phe?Ser?Ala?Leu?Val?Gln?Lys?Gly?Tyr?Gln?Lys?Gly?Asp?Glu?Ile

115 120 125

Leu?Ile?Asn?Ser?Ile?Pro?Arg?Ala?Leu?Ala?Glu?Thr?Asp?Lys?Val?Cys

130 135 140

Ser?Ser?Val?Asn?Ile?Gly?Ser?Thr?Lys?Ser?Gly?Ile?Asn?Met?Thr?Ala

145 150 155 160

Val?Ala?Asp?Met?Gly?Arg?Ile?Ile?Lys?Glu?Thr?Ala?Asn?Leu?Ser?Asp

165 170 175

Met?Gly?Val?Ala?Lys?Leu?Val?Val?Phe?Ala?Asn?Ala?Val?Glu?Asp?Asn

180 185 190

Pro?Phe?Met?Ala?Gly?Ala?Phe?His?Gly?Val?Gly?Glu?Ala?Asp?Val?Ile

195 200 205

Ile?Asn?Val?Gly?Val?Ser?Gly?Pro?Gly?Val?Val?Lys?Arg?Ala?Leu?Glu

210 215 220

Lys?Val?Arg?Gly?Gln?Ser?Phe?Asp?Val?Val?Ala?Glu?Thr?Val?Lys?Lys

225 230 235 240

Thr?Ala?Phe?Lys?Ile?Thr?Arg?Ile?Gly?Gln?Leu?Val?Gly?Gln?Met?Ala

245 250 255

Ser?Glu?Arg?Leu?Gly?Val?Glu?Phe?Gly?Ile?Val?Asp?Leu?Ser?Leu?Ala

260 265 270

Pro?Thr?Pro?Ala?Val?Gly?Asp?Ser?Val?Ala?Arg?Val?Leu?Glu?Glu?Met

275 280 285

Gly?Leu?Glu?Thr?Val?Gly?Thr?His?Gly?Thr?Thr?Ala?Ala?Leu?Ala?Leu

290 295 300

Leu?Asn?Asp?Gln?Val?Lys?Lys?Gly?Gly?Val?Met?Ala?Cys?Asn?Gln?Val

305 310 315 320

Gly?Gly?Leu?Ser?Gly?Ala?Phe?Ile?Pro?Val?Ser?Glu?Asp?Glu?Gly?Met

325 330 335

Ile?Ala?Ala?Val?Gln?Asn?Gly?Ser?Leu?Asn?Leu?Glu?Lys?Leu?Glu?Ala

340 345 350

Met?Thr?Ala?Ile?Cys?Ser?Val?Gly?Leu?Asp?Met?Ile?Ala?Ile?Pro?Glu

355 360 365

Asp?Thr?Pro?Ala?Glu?Thr?Ile?Ala?Ala?Met?Ile?Ala?Asp?Glu?Ala?Ala

370 375 380

Ile?Gly?Val?Ile?Asn?Met?Lys?Thr?Thr?Ala?Val?Arg?Ile?Ile?Pro?Lys

385 390 395 400

Gly?Lys?Glu?Gly?Asp?Met?Ile?Glu?Phe?Gly?Gly?Leu?Leu?Gly?Thr?Ala

405 410 415

Pro?Val?Met?Lys?Val?Asn?Gly?Ala?Ser?Ser?Val?Asp?Phe?Ile?Ser?Arg

420 425 430

Gly?Gly?Gln?Ile?Pro?Ala?Pro?Ile?His?Ser?Phe?Lys?Asn

435 440 445

<210>31

<211>285

<212>PRT

＜213〉streptococcus pneumoniae

<400>31

Met?Thr?Gln?Ile?Ile?Asp?Gly?Lys?Ala?Leu?Ala?Ala?Lys?Leu?Gln?Gly

1 5 10 15

Gln?Leu?Ala?Glu?Lys?Thr?Ala?Lys?Leu?Lys?Glu?Glu?Thr?Gly?Leu?Val

20 25 30

Pro?Gly?Leu?Val?Val?Ile?Leu?Val?Gly?Asp?Asn?Pro?Ala?Ser?Gln?Val

35 40 45

Tyr?Val?Arg?Asn?Lys?Glu?Arg?Ser?Ala?Leu?Ala?Ala?Gly?Phe?Arg?Ser

50 55 60

Glu?Val?Val?Arg?Val?Pro?Glu?Thr?Ile?Thr?Gln?Glu?Glu?Leu?Leu?Asp

65 70 75 80

Leu?Ile?Ala?Lys?Tyr?Asn?Gln?Asp?Pro?Ala?Trp?His?Gly?Ile?Leu?Val

85 90 95

Gln?Leu?Pro?Leu?Pro?Lys?His?Ile?Asp?Glu?Glu?Ala?Val?Leu?Leu?Ala

100 105 110

Ile?Asp?Pro?Glu?Lys?Asp?Val?Asp?Gly?Phe?His?Pro?Leu?Asn?Met?Gly

115 120 125

Arg?Leu?Trp?Ser?Gly?His?Pro?Val?Met?Ile?Pro?Ser?Thr?Pro?Ala?Gly

130 135 140

Ile?Met?Glu?Met?Phe?His?Glu?Tyr?Gly?Ile?Asp?Leu?Glu?Gly?Lys?Asn

145 150 155 160

Ala?Val?Val?Ile?Gly?Arg?Ser?Asn?Ile?Val?Gly?Lys?Pro?Met?Ala?Gln

165 170 175

Leu?Leu?Leu?Ala?Lys?Asn?Ala?Thr?Val?Thr?Leu?Thr?His?Ser?Arg?Thr

180 185 190

His?Asn?Leu?Ser?Lys?Val?Ala?Ala?Lys?Ala?Asp?Ile?Leu?Val?Val?Ala

195 200 205

Ile?Gly?Arg?Ala?Lys?Phe?Val?Thr?Ala?Asp?Phe?Val?Lys?Pro?Gly?Ala

210 215 220

Val?Val?Ile?Asp?Val?Gly?Met?Asn?Arg?Asp?Glu?Asn?Gly?Lys?Leu?Cys

225 230 235 240

Gly?Asp?Val?Asp?Tyr?Glu?Ala?Val?Ala?Pro?Leu?Ala?Ser?His?Ile?Thr

245 250 255

Pro?Val?Pro?Gly?Gly?Val?Gly?Pro?Met?Thr?Ile?Thr?Met?Leu?Met?Glu

260 265 270

Gln?Thr?Tyr?Gln?Ala?Ala?Leu?Arg?Thr?Leu?Asp?Arg?Lys

275 280 285

<210>32

<211>403

<212>PRT

＜213〉streptococcus pneumoniae

<400>32

Met?Ser?Lys?Phe?Asn?Arg?Ile?His?Leu?Val?Val?Leu?Asp?Ser?Val?Gly

1 5 10 15

Ile?Gly?Ala?Ala?Pro?Asp?Ala?Asn?Asn?Phe?Val?Asn?Ala?Gly?Val?Pro

20 25 30

Asp?Gly?Ala?Ser?Asp?Thr?Leu?Gly?His?Ile?Ser?Lys?Thr?Val?Gly?Leu

35 40 45

Asn?Val?Pro?Asn?Met?Ala?Lys?Ile?Gly?Leu?Gly?Asn?Ile?Pro?Arg?Glu

50 55 60

Thr?Pro?Leu?Lys?Thr?Val?Ala?Ala?Glu?Ser?Asn?Pro?Thr?Gly?Tyr?Ala

65 70 75 80

Thr?Lys?Leu?Glu?Glu?Val?Ser?Leu?Gly?Lys?Asp?Thr?Met?Thr?Gly?His

85 90 95

Trp?Glu?Ile?Met?Gly?Leu?Asn?Ile?Thr?Glu?Pro?Phe?Asp?Thr?Phe?Trp

100 105 110

Asn?Gly?Phe?Pro?Glu?Glu?Ile?Leu?Thr?Lys?Ile?Glu?Glu?Phe?Ser?Gly

115 120 125

Arg?Lys?Val?Ile?Arg?Glu?Ala?Asn?Lys?Pro?Tyr?Ser?Gly?Thr?Ala?Val

130 135 140

Ile?Tyr?Asp?Phe?Gly?Pro?Arg?Gln?Met?Glu?Thr?Gly?Glu?Leu?Ile?Ile

145 150 155 160

Tyr?Thr?Ser?Ala?Asp?Pro?Val?Leu?Gln?Ile?Ala?Ala?His?Glu?Asp?Ile

165 170 175

Ile?Pro?Leu?Asp?Glu?Leu?Tyr?Arg?Ile?Cys?Glu?Tyr?Ala?Arg?Ser?Ile

180 185 190

Thr?Leu?Glu?Arg?Pro?Ala?Leu?Leu?Gly?Arg?Ile?Ile?Ala?Arg?Pro?Tyr

195 200 205

Val?Gly?Glu?Pro?Gly?Asn?Phe?Thr?Arg?Thr?Ala?Asn?Arg?Arg?Asp?Leu

210 215 220

Ala?Val?Ser?Pro?Phe?Phe?Pro?Thr?Val?Leu?Asp?Lys?Leu?Asn?Glu?Ala

225 230 235 240

Gly?Ile?Asp?Thr?Tyr?Ala?Val?Gly?Lys?Ile?Asn?Asp?Ile?Phe?Asn?Gly

245 250 255

Ala?Gly?Ile?Asn?His?Asp?Met?Gly?His?Asn?Lys?Ser?Asn?Ser?His?Gly

260 265 270

Ile?Asp?Thr?Leu?Leu?Lys?Thr?Met?Gly?Leu?Ala?Glu?Phe?Glu?Lys?Gly

275 280 285

Phe?Ser?Phe?Thr?Asn?Leu?Val?Asp?Phe?Asp?Ala?Leu?Tyr?Gly?His?Arg

290 295 300

Arg?Asn?Ala?His?Gly?Tyr?Arg?Asp?Cys?Leu?His?Glu?Phe?Asp?Glu?Arg

305 310 315 320

Leu?Pro?Glu?Ile?Ile?Ala?Ala?Met?Arg?Glu?Asn?Asp?Leu?Leu?Leu?Ile

325 330 335

Thr?Ala?Asp?His?Gly?Asn?Asp?Pro?Thr?Tyr?Ala?Gly?Thr?Asp?His?Thr

340 345 350

Arg?Glu?Tyr?Ile?Pro?Leu?Leu?Ala?Tyr?Ser?Pro?Ala?Phe?Lys?Gly?Asn

355 360 365

Gly?Leu?Ile?Pro?Val?Gly?His?Phe?Ala?Asp?Ile?Ser?Ala?Thr?Val?Ala

370 375 380

Asp?Asn?Phe?Gly?Val?Glu?Thr?Ala?Met?Ile?Gly?Glu?Ser?Phe?Leu?Asp

385 390 395 400

Lys?Leu?Val

<210>33

<211>326

<212>PRT

＜213〉streptococcus pneumoniae

<400>33

Met?Phe?Ile?Ser?Ile?Ser?Ala?Gly?Ile?Val?Thr?Phe?Leu?Leu?Thr?Leu

1 5 10 15

Val?Glu?Ile?Pro?Ala?Phe?Ile?Gln?Phe?Tyr?Arg?Lys?Ala?Gln?Ile?Thr

20 25 30

Gly?Gln?Gln?Met?His?Glu?Asp?Val?Lys?Gln?His?Gln?Ala?Lys?Ala?Gly

35 40 45

Thr?Pro?Thr?Met?Gly?Gly?Leu?Val?Phe?Leu?Ile?Thr?Ser?Val?Leu?Val

50 55 60

Ala?Phe?Phe?Phe?Ala?Leu?Phe?Ser?Ser?Gln?Phe?Ser?Asn?Asn?Val?Gly

65 70 75 80

Met?Ile?Leu?Phe?Ile?Leu?Val?Leu?Tyr?Gly?Leu?Val?Gly?Phe?Leu?Asp

85 90 95

Asp?Phe?Leu?Lys?Val?Phe?Arg?Lys?Ile?Asn?Glu?Gly?Leu?Asn?Pro?Lys

100 105 110

Gln?Lys?Leu?Ala?Leu?Gln?Leu?Leu?Gly?Gly?Val?Ile?Phe?Tyr?Leu?Phe

115 120 125

Tyr?Glu?Arg?Gly?Gly?Asp?Ile?Leu?Ser?Val?Phe?Gly?Tyr?Pro?Val?His

130 135 140

Leu?Gly?Phe?Phe?Tyr?Ile?Phe?Phe?Ala?Leu?Phe?Trp?Leu?Val?Gly?Phe

145 150 155 160

Ser?Asn?Ala?Val?Asn?Leu?Thr?Asp?Gly?Val?Asp?Gly?Leu?Ala?Ser?Ile

165 170 175

Ser?Val?Val?Ile?Ser?Leu?Ser?Ala?Tyr?Gly?Val?Ile?Ala?Tyr?Val?Gln

180 185 190

Gly?Gln?Met?Asp?Ile?Leu?Leu?Val?Ile?Leu?Ala?Met?Ile?Gly?Gly?Leu

195 200 205

Leu?Gly?Phe?Phe?Ile?Phe?Asn?His?Lys?Pro?Ala?Lys?Val?Phe?Met?Gly

210 215 220

Asp?Val?Gly?Ser?Leu?Ala?Leu?Gly?Gly?Met?Leu?Ala?Ala?Ile?Ser?Met

225 230 235 240

Ala?Leu?His?Gln?Glu?Trp?Thr?Leu?Leu?Ile?Ile?Gly?Ile?Val?Tyr?Val

245 250 255

Phe?Glu?Thr?Thr?Ser?Val?Met?Met?Gln?Val?Ser?Tyr?Phe?Lys?Leu?Thr

260 265 270

Gly?Gly?Lys?Arg?Ile?Phe?Arg?Met?Thr?Pro?Val?His?His?His?Phe?Glu

275 280 285

Leu?Gly?Gly?Leu?Ser?Gly?Lys?Gly?Asn?Pro?Trp?Ser?Glu?Trp?Lys?Val

290 295 300

Asp?Phe?Phe?Phe?Trp?Gly?Val?Gly?Leu?Leu?Ala?Ser?Leu?Leu?Thr?Leu

305 310 315 320

Ala?Ile?Leu?Tyr?Leu?Met

325

<210>34

<211>426

<212>PRT

＜213〉streptococcus pneumoniae

<400>34

Leu?Phe?Lys?Lys?Asn?Lys?Asp?Ile?Leu?Asn?Ile?Ala?Leu?Pro?Ala?Met

1 5 10 15

Gly?Glu?Asn?Phe?Leu?Gln?Met?Leu?Met?Gly?Met?Val?Asp?Ser?Tyr?Leu

20 25 30

Val?Ala?His?Leu?Gly?Leu?Ile?Ala?Ile?Ser?Gly?Val?Ser?Val?Ala?Gly

35 40 45

Asn?Ile?Ile?Thr?Ile?Tyr?Gln?Ala?Ile?Phe?Ile?Ala?Leu?Gly?Ala?Ala

50 55 60

Ile?Ser?Ser?Val?Ile?Ser?Lys?Ser?Ile?Gly?Gln?Lys?Asp?Gln?Ser?Lys

65 70 75 80

Leu?Ala?Tyr?His?Val?Thr?Glu?Ala?Leu?Lys?Ile?Thr?Leu?Leu?Leu?Ser

85 90 95

Phe?Leu?Leu?Gly?Phe?Leu?Ser?Ile?Phe?Ala?Gly?Lys?Glu?Met?Ile?Gly

100 105 110

Leu?Leu?Gly?Thr?Glu?Arg?Asp?Val?Ala?Glu?Ser?Gly?Gly?Leu?Tyr?Leu

115 120 125

Ser?Leu?Val?Gly?Gly?Ser?Ile?Val?Leu?Leu?Gly?Leu?Met?Thr?Ser?Leu

130 135 140

Gly?Ala?Leu?Ile?Arg?Ala?Thr?His?Asn?Pro?Arg?Leu?Pro?Leu?Tyr?Val

145 150 155 160

Ser?Phe?Leu?Ser?Asn?Ala?Leu?Asn?Ile?Leu?Phe?Ser?Ser?Leu?Ala?Ile

165 170 175

Phe?Val?Leu?Asp?Met?Gly?Ile?Ala?Gly?Val?Ala?Trp?Gly?Thr?Ile?Val

180 185 190

Ser?Arg?Leu?Val?Gly?Leu?Val?Ile?Leu?Trp?Ser?Gln?Leu?Lys?Leu?Pro

195 200 205

Tyr?Gly?Lys?Pro?Thr?Phe?Gly?Leu?Asp?Lys?Glu?Leu?Leu?Thr?Leu?Ala

210 215 220

Leu?Pro?Ala?Ala?Gly?Glu?Arg?Leu?Met?Met?Arg?Ala?Gly?Asp?Val?Val

225 230 235 240

Ile?Ile?Ala?Leu?Val?Val?Ser?Phe?Gly?Thr?Glu?Ala?Val?Ala?Gly?Asn

245 250 255

Ala?Ile?Gly?Glu?Val?Leu?Thr?Gln?Phe?Asn?Tyr?Met?Pro?Ala?Phe?Gly

260 265 270

Val?Ala?Thr?Ala?Thr?Val?Met?Leu?Leu?Ala?Arg?Ala?Val?Gly?Glu?Asp

275 280 285

Asp?Trp?Lys?Arg?Val?Ala?Ser?Leu?Ser?Lys?Gln?Thr?Phe?Trp?Leu?Ser

290 295 300

Leu?Phe?Leu?Met?Leu?Pro?Leu?Ser?Phe?Ser?Ile?Tyr?Val?Leu?Gly?Val

305 310 315 320

Pro?Leu?Thr?His?Leu?Tyr?Thr?Thr?Asp?Ser?Leu?Ala?Val?Glu?Ala?Ser

325 330 335

Val?Leu?Val?Thr?Leu?Phe?Ser?Leu?Leu?Gly?Thr?Pro?Met?Thr?Thr?Gly

340 345 350

Thr?Val?Ile?Tyr?Thr?Ala?Val?Trp?Gln?Gly?Leu?GlyAsn?Ala?Arg?Leu

355 360 365

Pro?Phe?Tyr?Ala?Thr?Ser?Ile?Gly?Met?Trp?Cys?Ile?Arg?Ile?Gly?Thr

370 375 380

Gly?Tyr?Leu?Met?Gly?Ile?Val?Leu?Gly?Trp?Gly?Leu?Pro?Gly?Ile?Trp

385 390 395 400

Ala?Gly?Ser?Leu?Leu?Asp?Asn?Gly?Phe?Arg?Trp?Leu?Phe?Leu?Arg?Tyr

405 410 415

Arg?Tyr?Gln?Arg?Tyr?Met?Ser?Leu?Lys?Gly

420 425

<210>35

<211>420

<212>PRT

＜213〉streptococcus pneumoniae

<400>35

Met?Gln?Thr?Gln?Glu?Lys?His?Ser?Gln?Ala?Ala?Val?Leu?Gly?Leu?Gln

1 5 10 15

His?Leu?Leu?Ala?Met?Tyr?Ser?Gly?Ser?Ile?Leu?Val?Pro?Ile?Met?Ile

20 25 30

Ala?Thr?Ala?Leu?Gly?Tyr?Ser?Ala?Glu?Gln?Leu?Thr?Tyr?Leu?Ile?Ser

35 40 45

Thr?Asp?Ile?Phe?Met?Cys?Gly?Val?Ala?Thr?Phe?Leu?Gln?Leu?Gln?Leu

50 55 60

Asn?Lys?Tyr?Phe?Gly?Ile?Gly?Leu?Pro?Val?Val?Leu?Gly?Val?Ala?Phe

65 70 75 80

Gln?Ser?Val?Ala?Pro?Leu?Ile?Met?Ile?Gly?Gln?Ser?His?Gly?Ser?Gly

85 90 95

Ala?Met?Phe?Gly?Ala?Leu?Ile?Ala?Ser?Gly?Ile?Tyr?Val?Val?Leu?Val

100 105 110

Ser?Gly?Ile?Phe?Ser?Lys?Val?Ala?Asn?Leu?Phe?Pro?Ser?Ile?Val?Thr

115 120 125

Gly?Ser?Val?Ile?Thr?Thr?Ile?Gly?Leu?Thr?Leu?Ile?Pro?Val?Ala?Ile

130 135 140

Gly?Asn?Met?Gly?Asn?Asn?Val?Pro?Glu?Pro?Thr?Gly?Gln?Ser?Leu?Leu

145 150 155 160

Leu?Ala?Ala?Ile?Thr?Val?Leu?Ile?Ile?Leu?Leu?Ile?Asn?Ile?Phe?Thr

165 170 175

Lys?Gly?Phe?Ile?Lys?Ser?Ile?Ser?Ile?Leu?Ile?Gly?Leu?Val?Val?Gly

180 185 190

Thr?Ala?Ile?Ala?Ala?Thr?Met?Gly?Leu?Val?Asp?Phe?Ser?Pro?Val?Ala

195 200 205

Val?Ala?Pro?Leu?Val?His?Val?Pro?Thr?Pro?Leu?Tyr?Phe?Gly?Met?Pro

210 215 220

Thr?Phe?Glu?Ile?Ser?Ser?Ile?Val?Met?Met?Cys?Ile?Ile?Ala?Thr?Val

225 230 235 240

Ser?Met?Val?Glu?Ser?Thr?Gly?Val?Tyr?Leu?Ala?Leu?Ser?Asp?Ile?Thr

245 250 255

Lys?Asp?Pro?Ile?Asp?Ser?Thr?Arg?Leu?Arg?Asn?Gly?Tyr?Arg?Ala?Glu

260 265 270

Gly?Leu?Ala?Val?Leu?Leu?Gly?Gly?Ile?Phe?Asn?Thr?Phe?Pro?Tyr?Thr

275 280 285

Gly?Phe?Ser?Gln?Asn?Val?Gly?Leu?Val?Lys?Leu?Ser?Gly?Ile?Lys?Lys

290 295 300

Arg?Leu?Pro?Ile?Tyr?Tyr?Ala?Ala?Gly?Phe?Leu?Val?Leu?Leu?Gly?Leu

305 310 315 320

Leu?Pro?Lys?Phe?Gly?Ala?Leu?Ala?Gln?Ile?Ile?Pro?Ser?Ser?Val?Leu

325 330 335

Gly?Gly?Ala?Met?Leu?Val?Met?Phe?Gly?Phe?Val?Ser?Ile?Gln?Gly?Met

340 345 350

Gln?Ile?Leu?Ala?Arg?Val?Asp?Phe?Ala?Asn?Asn?Glu?His?Asn?Phe?Leu

355 360 365

Ile?Ala?Ala?Val?Ser?Ile?Ala?Ala?Gly?Val?Gly?Leu?Asn?Asn?Ser?Asn

370 375 380

Leu?Phe?Val?Ser?Met?Pro?Thr?Ala?Phe?Gln?Met?Phe?Phe?Ser?Asn?Gly

385 390 395 400

Ile?Val?Val?Ala?Ser?Leu?Leu?Ala?Ile?Val?Leu?Asn?Ala?Val?Leu?Asn

405 410 415

His?Lys?Lys?Lys

420

<210>36

<211>784

<212>PRT

＜213〉streptococcus pneumoniae

<400>36

Met?Lys?Asp?Arg?Ile?Lys?Glu?Tyr?Leu?Gln?Asp?Lys?Gly?Lys?Val?Thr

1 5 10 15

Val?Asn?Asp?Leu?Ala?Gln?Ala?Leu?Gly?Lys?Asp?Ser?Ser?Lys?Asp?Phe

20 25 30

Arg?Glu?Leu?Ile?Lys?Thr?Leu?Ser?Leu?Met?Glu?Arg?Lys?His?Gln?Ile

35 40 45

Arg?Phe?Glu?Glu?Asp?Gly?Ser?Leu?Thr?Leu?Glu?Ile?Lys?Lys?Lys?His

50 55 60

Glu?Ile?Thr?Leu?Lys?Gly?Ile?Phe?His?Ala?His?Lys?Asn?Gly?Phe?Gly

65 70 75 80

Phe?Val?Ser?Leu?Glu?Gly?Glu?Glu?Asp?Asp?Leu?Phe?Val?Gly?Lys?Asn

85 90 95

Asp?Val?Asn?Tyr?Ala?Ile?Asp?Gly?Asp?Thr?Val?Glu?Val?Val?Ile?Lys

100 105 110

Lys?Val?Ala?Asp?Arg?Asn?Lys?Gly?Thr?Ala?Ala?Glu?Ala?Lys?Ile?Ile

115 120 125

Asp?Ile?Leu?Glu?His?Ser?Leu?Thr?Thr?Val?Val?Gly?Gln?Ile?Val?Leu

130 135 140

Asp?Gln?Glu?Lys?Pro?Lys?Tyr?Ala?Gly?Tyr?Ile?Arg?Ser?Lys?Asn?Gln

145 150 155 160

Lys?Ile?Ser?Gln?Pro?Ile?Tyr?Val?Lys?Lys?Pro?Ala?Leu?Lys?Leu?Glu

165 170 175

Gly?Thr?Glu?Val?Leu?Lys?Val?Phe?Ile?Asp?Lys?Tyr?Pro?Ser?Lys?Lys

180 185 190

His?Asp?Phe?Phe?Val?Ala?Ser?Val?Leu?Asp?Val?Val?Gly?His?Ser?Thr

195 200 205

Asp?Val?Gly?Ile?Asp?Val?Leu?Glu?Val?Leu?Glu?Ser?Met?Asp?Ile?Val

210 215 220

Ser?Glu?Phe?Pro?Glu?Ala?Val?Val?Lys?Glu?Ala?Glu?Ser?Val?Pro?Asp

225 230 235 240

Ala?Pro?Ser?Gln?Lys?Asp?Met?Glu?Gly?Arg?Leu?Asp?Leu?Arg?Asp?Glu

245 250 255

Ile?Thr?Phe?Thr?Ile?Asp?Gly?Ala?Asp?Ala?Lys?Asp?Leu?Asp?Asp?Ala

260 265 270

Val?His?Ile?Lys?Ala?Leu?Lys?Asn?Gly?Asn?Leu?Glu?Phe?Gly?Val?His

275 280 285

Ile?Ala?Asp?Val?Ser?Tyr?Tyr?Val?Thr?Glu?Gly?Ser?Ala?Leu?Asp?Lys

290 295 300

Glu?Ala?Leu?Asn?Arg?Ala?Thr?Ser?Val?Tyr?Val?Thr?Asp?Arg?Val?Val

305 310 315 320

Pro?Met?Leu?Pro?Glu?Arg?Leu?Ser?Asn?Gly?Ile?Cys?Ser?Leu?Asn?Pro

325 330 335

Gln?Val?Asp?Arg?Leu?Thr?Gln?Ser?Ala?Ile?Met?Glu?Ile?Asp?Lys?His

340 345 350

Gly?Arg?Val?Val?Asn?Tyr?Thr?Ile?Thr?Gln?Thr?Val?Ile?Lys?Thr?Ser

355 360 365

Phe?Arg?Met?Thr?Tyr?Ser?Asp?Val?Asn?Asp?Ile?Leu?Ala?Gly?Asp?Glu

370 375 380

Glu?Lys?Arg?Lys?Glu?Tyr?His?Lys?Ile?Val?Ser?Ser?Ile?Glu?Leu?Met

385 390 395 400

Ala?Lys?Leu?His?Glu?Thr?Leu?Glu?Asn?Met?Arg?Val?Lys?Arg?Gly?Ala

405 410 415

Leu?Asn?Phe?Asp?Thr?Asn?Glu?Ala?Lys?Ile?Leu?Val?Asp?Lys?Gln?Gly

420 425 430

Lys?Pro?Val?Asp?Ile?Val?Leu?Arg?Gln?Arg?Gly?Ile?Ala?Glu?Arg?Met

435 440 445

Ile?Glu?Ser?Phe?Met?Leu?Met?Ala?Asn?Glu?Thr?Val?Ala?Glu?His?Phe

450 455 460

Ser?Lys?Leu?Asp?Leu?Pro?Phe?Ile?Tyr?Arg?Ile?His?Glu?Glu?Pro?Lys

465 470 475 480

Ala?Glu?Lys?Val?Gln?Lys?Phe?Ile?Asp?Tyr?Ala?Ser?Ser?Phe?Gly?Leu

485 490 495

Arg?Ile?Tyr?Gly?Thr?Ala?Ser?Glu?Ile?Ser?Gln?Glu?Ala?Leu?Gln?Asp

500 505 510

Ile?Met?Arg?Ala?Val?Glu?Gly?Glu?Pro?Tyr?Ala?Asp?Val?Leu?Ser?Met

515 520 525

Met?Leu?Leu?Arg?Ser?Met?Gln?Gln?Ala?Arg?Tyr?Ser?Glu?His?Asn?His

530 535 540

Gly?His?Tyr?Gly?Leu?Ala?Ala?Asp?Tyr?Tyr?Thr?His?Phe?Thr?Ser?Pro

545 550 555 560

Ile?Arg?Arg?Tyr?Pro?Asp?Leu?Leu?Val?His?Arg?Met?Ile?Arg?Asp?Tyr

565 570 575

Gly?Arg?Ser?Lys?Glu?Ile?Ala?Glu?His?Phe?Glu?Gln?Val?Ile?Pro?Glu

580 585 590

Ile?Ala?Thr?Gln?Ser?Ser?Asn?Arg?Glu?Arg?Arg?Ala?Ile?Glu?Ala?Glu

595 600 605

Arg?Glu?Val?Glu?Ala?Met?Lys?Lys?Ala?Glu?Tyr?Met?Glu?Glu?Tyr?Val

610 615 620

Gly?Glu?Glu?Tyr?Asp?Ala?Val?Val?Ser?Ser?Ile?Val?Lys?Phe?Gly?Leu

625 630 635 640

Phe?Val?Glu?Leu?Pro?Asn?Thr?Val?Glu?Gly?Leu?Ile?His?Ile?Thr?Asn

645 650 655

Leu?Pro?Glu?Phe?Tyr?His?Phe?Asn?Glu?Arg?Asp?Leu?Thr?Leu?Arg?Gly

660 665 670

Glu?Lys?Ser?Gly?Ile?Thr?Phe?Arg?Val?Gly?Gln?Gln?Ile?Arg?Ile?Arg

675 680 685

Val?Glu?Arg?Ala?Asp?Lys?Met?Thr?Gly?Glu?Ile?Asp?Phe?Ser?Phe?Val

690 695 700

Pro?Ser?Glu?Phe?Asp?Val?Ile?Glu?Lys?Gly?Leu?Lys?Gln?Ser?Ser?Arg

705 710 715 720

Ser?Gly?Arg?Gly?Arg?Asp?Ser?Asn?Arg?Arg?Ser?Asp?Lys?Lys?Glu?Asp

725 730 735

Lys?Arg?Lys?Ser?Gly?Arg?Ser?Asn?Asp?Lys?Arg?Lys?His?Ser?Gln?Lys

740 745 750

Asp?Lys?Lys?Lys?Lys?Gly?Lys?Lys?Pro?Phe?Tyr?Lys?Glu?Val?Ala?Lys

755 760 765

Lys?Gly?Ala?Lys?His?Gly?Lys?Gly?Arg?Gly?Lys?Gly?Arg?Arg?Thr?Lys

770 775 780

<210>37

<211>513

<212>PRT

＜213〉streptococcus pneumoniae

<400>37

Met?Gly?Thr?Thr?Gly?Phe?Thr?Ile?Ile?Asp?Leu?Ile?Ile?Leu?Ile?Val

1 5 10 15

Tyr?Leu?Leu?Ala?Val?Leu?Val?Ala?Gly?Ile?Tyr?Phe?Ser?Lys?Lys?Glu

20 25 30

Met?Lys?Gly?Lys?Glu?Phe?Phe?Lys?Gly?Asp?Gly?Ser?Val?Pro?Trp?Tyr

35 40 45

Val?Thr?Ser?Val?Ser?Ile?Phe?Ala?Thr?Met?Leu?Ser?Pro?Ile?Ser?Phe

50 55 60

Leu?Gly?Leu?Ala?Gly?Ser?Ser?Tyr?Ala?Gly?Ser?Trp?Ile?Leu?Trp?Phe

65 70 75 80

Ala?Gln?Leu?Gly?Met?Val?Val?Ala?Ile?Pro?Leu?Thr?Ile?Arg?Phe?Ile

85 90 95

Leu?Pro?Ile?Phe?Ala?Arg?Ile?Asp?Ile?Asp?Thr?Ala?Tyr?Asp?Tyr?Leu

100 105 110

Asp?Lys?Arg?Phe?Asn?Ser?Lys?Ala?Leu?Arg?Ile?Ile?Ser?Ala?Leu?Leu

115 120 125

Phe?Ile?Ile?Tyr?Gln?Leu?Gly?Arg?Met?Ser?Ile?Ile?Met?Tyr?Leu?Pro

130 135 140

Ser?Ala?Gly?Leu?Ser?Val?Leu?Thr?Gly?Ile?Asp?Ile?Asn?Ile?Leu?Ile

145 150 155 160

Ile?Leu?Met?Gly?Val?Val?Ala?Ile?Val?Tyr?Ser?Tyr?Thr?Gly?Gly?Leu

165 170 175

Lys?Ser?Val?Leu?Trp?Thr?Asp?Phe?Ile?Gln?Gly?Val?Ile?Leu?Ile?Ser

180 185 190

Gly?Val?Val?Leu?Ala?Leu?Phe?Val?Leu?Ile?Ala?Asn?Ile?Lys?Gly?Gly

195 200 205

Phe?Gly?Ala?Val?Ala?Glu?Thr?Leu?Ala?Asn?Gly?Lys?Phe?Leu?Ala?Ala

210 215 220

Asn?Glu?Lys?Leu?Phe?Asp?Pro?Asn?Leu?Leu?Ser?Asn?Ser?Ile?Phe?Leu

225 230 235 240

Ile?Val?Met?Gly?Ser?Gly?Phe?Thr?Ile?Leu?Ser?Ser?Tyr?Ala?Ser?Ser

245 250 255

Gln?Asp?Leu?Val?Gln?Arg?Phe?Thr?Thr?Thr?Gln?Asn?Ile?Lys?Lys?Leu

260 265 270

Asn?Lys?Met?Leu?Phe?Thr?Asn?Gly?Val?Leu?Ser?Leu?Ala?Thr?Ala?Thr

275 280 285

Val?Phe?Tyr?Leu?Ile?Gly?Thr?Gly?Leu?Tyr?Val?Phe?Tyr?Gln?Val?Gln

290 295 300

Asn?Ala?Asp?Ser?Ala?Ala?Ser?Asn?Ile?Pro?Gln?Asp?Gln?Ile?Phe?Met

305 310 315 320

Tyr?Phe?Ile?Ala?Tyr?Gln?Leu?Pro?Val?Gly?Ile?Thr?Gly?Leu?Ile?Leu

325 330 335

Ala?Ala?Ile?Tyr?Ala?Ala?Ser?Gln?Ser?Thr?Ile?Ser?Thr?Gly?Leu?Asn

340 345 350

Ser?Val?Ala?Thr?Ser?Trp?Thr?Leu?Asp?Ile?Gln?Asp?Val?Ile?Ser?Lys

355 360 365

Asn?Met?Ser?Asp?Asn?Arg?Arg?Thr?Lys?Ile?Ala?Gln?Phe?Val?Ser?Leu

370 375 380

Ala?Val?Gly?Leu?Phe?Ser?Ile?Gly?Val?Ser?Ile?Val?Met?Ala?His?Ser

385 390 395 400

Asp?Ile?Lys?Ser?Ala?Tyr?Glu?Trp?Phe?Asn?Ser?Phe?Met?Gly?Leu?Val

405 410 415

Leu?Gly?Leu?Leu?Gly?Gly?Val?Phe?Ile?Leu?Gly?Phe?Val?Ser?Lys?Lys

420 425 430

Ala?Asn?Lys?Gln?Gly?Ala?Tyr?Ala?Ala?Leu?Ile?Val?Ser?Thr?Ile?Val

435 440 445

Met?Val?Phe?Ile?Lys?Tyr?Phe?Leu?Pro?Pro?Thr?Ala?Val?Ser?Tyr?Trp

450 455 460

Ala?Tyr?Ser?Leu?Ile?Ser?Ile?Ser?Val?Ser?Val?Val?Ser?Gly?Tyr?Ile

465 470 475 480

Val?Ser?Val?Leu?Thr?Gly?Asn?Lys?Val?Ser?Ala?Pro?Lys?Tyr?Thr?Thr

485 490 495

Ile?His?Asp?Ile?Thr?Glu?Ile?Lys?Ala?Asp?Ser?Ser?Trp?Glu?Val?Arg

500 505 510

His

<210>38

<211>484

<212>PRT

＜213〉streptococcus pneumoniae

<400>38

Met?Lys?Phe?Ser?Lys?Lys?Tyr?Ile?Ala?Ala?Gly?Ser?Ala?Val?Ile?Val

1 5 10 15

Ser?Leu?Ser?Leu?Cys?Ala?Tyr?Ala?Leu?Asn?Gln?His?Arg?Ser?Gln?Glu

20 25 30

Asn?Lys?Asp?Asn?Asn?Arg?Val?Ser?Tyr?Val?Asp?Gly?Ser?Gln?Ser?Ser

35 40 45

Gln?Lys?Ser?Glu?Asn?Leu?Thr?Pro?Asp?Gln?Val?Ser?Gln?Lys?Glu?Gly

50 55 60

Ile?Gln?Ala?Glu?Gln?Ile?Val?Ile?Lys?Ile?Thr?Asp?Gln?Gly?Tyr?Val

65 70 75 80

Thr?Ser?His?Gly?Asp?His?Tyr?His?Tyr?Tyr?Asn?Gly?Lys?Val?Pro?Tyr

85 90 95

Asp?Ala?Leu?Phe?Ser?Glu?Glu?Leu?Leu?Met?Lys?Asp?Pro?Asn?Tyr?Gln

100 105 110

Leu?Lys?Asp?Ala?Asp?Ile?Val?Asn?Glu?Val?Lys?Gly?Gly?Tyr?Ile?Ile

115 120 125

Lys?Val?Asp?Gly?Lys?Tyr?Tyr?Val?Tyr?Leu?Lys?Asp?Ala?Ala?His?Ala

130 135 140

Asp?Asn?Val?Arg?Thr?Lys?Asp?Glu?Ile?Asn?Arg?Gln?Lys?Gln?Glu?His

145 150 155 160

Val?Lys?Asp?Asn?Glu?Lys?Val?Asn?Ser?Asn?ValAla?Val?Ala?Arg?Ser

165 170 175

Gln?Gly?Arg?Tyr?Thr?Thr?Asn?Asp?Gly?Tyr?Val?Phe?Asn?Pro?Ala?Asp

180 185 190

Ile?Ile?Glu?Asp?Thr?Gly?Asn?Ala?Tyr?Ile?Val?Pro?His?Gly?Gly?His

195 200 205

Tyr?His?Tyr?Ile?Pro?Lys?Ser?Asp?Leu?Ser?Ala?Ser?Glu?Leu?Ala?Ala

210 215 220

Ala?Lys?Ala?His?Leu?Ala?Gly?Lys?Asn?Met?Gln?Pro?Ser?Gln?Leu?Ser

225 230 235 240

Tyr?Ser?Ser?Thr?Ala?Ser?Asp?Asn?Asn?Thr?Gln?Ser?Val?Ala?Lys?Gly

245 250 255

Ser?Thr?Ser?Lys?Pro?Ala?Asn?Lys?Ser?Glu?Asn?Leu?Gln?Ser?Leu?Leu

260 265 270

Lys?Glu?Leu?Tyr?Asp?Ser?Pro?Ser?Ala?Gln?Arg?Tyr?Ser?Glu?Ser?Asp

275 280 285

Gly?Leu?Val?Phe?Asp?Pro?Ala?LysIle?Ile?Ser?Arg?Thr?Pro?Asn?Gly

290 295 300

Val?Ala?Ile?Pro?His?Gly?Asp?His?Tyr?His?Phe?Ile?Pro?Tyr?Ser?Lys

305 310 315 320

Leu?Ser?Ala?Leu?Glu?Glu?Lys?Ile?Ala?Arg?Met?Val?Pro?Ile?Ser?Gly

325 330 335

Thr?Gly?Ser?Thr?Val?Ser?Thr?Asn?Ala?Lys?Pro?Asn?Glu?Val?Val?Ser

340 345 350

Ser?Leu?Gly?Ser?Leu?Ser?Ser?Asn?Pro?Ser?Ser?Leu?Thr?Thr?Ser?Lys

355 360 365

Glu?Leu?Ser?Ser?Ala?Ser?Asp?Gly?Tyr?Ile?Phe?Asn?Pro?Lys?Asp?Ile

370 375 380

Val?Glu?Glu?Thr?Ala?Thr?Ala?Tyr?Ile?Val?Arg?His?Gly?Asp?His?Phe

385 390 395 400

His?Tyr?Ile?Pro?Lys?Ser?Asn?Gln?Ile?Gly?Gln?Pro?Thr?Leu?Pro?Asn

405 410 415

Asn?Ser?Leu?Ala?Thr?Pro?Ser?Pro?Ser?Leu?ProIle?Asn?Pro?Gly?Thr

420 425 430

Ser?His?Glu?Lys?His?Glu?Glu?Asp?Gly?Tyr?Gly?Phe?Asp?Ala?Asn?Arg

435 440 445

Ile?Ile?Ala?Glu?Asp?Glu?Ser?Gly?Phe?Val?Met?Ser?His?Gly?Asp?His

450 455 460

Asn?His?Tyr?Phe?Phe?Lys?Lys?Asp?Leu?Thr?Glu?Glu?Gln?Ile?Lys?Val

465 470 475 480

Arg?Lys?Asn?Ile

<210>39

<211>153

<212>PRT

＜213〉streptococcus pneumoniae

<400>39

Met?Lys?Lys?Arg?Ala?Ile?Val?Ala?Val?Ile?Val?Leu?Leu?Leu?Ile?G?Ly

1 5 10 15

Leu?Asp?Gln?Leu?Val?Lys?Ser?Tyr?Ile?Val?Gln?Gln?Ile?Pro?Leu?Gly

20 25 30

Glu?Val?Arg?Ser?Trp?Ile?Pro?Asn?Phe?Val?Ser?Leu?Thr?Tyr?Leu?Gln

35 40 45

Asn?Arg?Gly?Ala?Ala?Phe?Ser?Ile?Leu?Gln?Asp?Gln?Gln?Leu?Leu?Phe

50 55 60

Ala?Val?Ile?Thr?Leu?Val?Val?Val?Ile?Gly?Ala?Ile?Trp?Tyr?Leu?His

65 70 75 80

Lys?His?Met?Glu?Asp?Ser?Phe?Trp?Met?Val?Leu?Gly?Leu?Thr?Leu?Ile

85 90 95

Ile?Ala?Gly?Gly?Leu?Gly?Asn?Phe?Ile?Asp?Arg?Val?Ser?Gln?Gly?Phe

100 105 110

Val?Val?Asp?Met?Phe?His?Leu?Asp?Phe?Ile?Asn?Phe?Ala?Ile?Phe?Asn

115 120 125

Val?Ala?Asp?Ser?Tyr?Leu?Thr?Val?Gly?Val?Ile?Ile?Leu?Leu?Ile?Ala

130 135 140

Met?Leu?Lys?Glu?Glu?Ile?Asn?Gly?Asn

145 150

<210>40

<211>284

<212>PRT

＜213〉streptococcus pneumoniae

<400>40

Met?Asn?Thr?Asn?Leu?Ala?Ser?Phe?Ile?Val?Gly?Leu?Ile?Ile?Asp?Glu

1 5 10 15

Asn?Asp?Arg?Phe?Tyr?Phe?Val?Gln?Lys?Asp?Gly?Gln?Thr?Tyr?Ala?Leu

20 25 30

Ala?Lys?Glu?Glu?Gly?Gln?His?Thr?Val?Gly?Asp?Thr?Val?Lys?Gly?Phe

35 40 45

Ala?Tyr?Thr?Asp?Met?Lys?Gln?Lys?Leu?Arg?Leu?Thr?Thr?Leu?Glu?Val

50 55 60

Thr?Ala?Thr?Gln?Asp?Gln?Phe?Gly?Trp?Gly?Arg?Val?Thr?Glu?Val?Arg

65 70 75 80

Lys?Asp?Leu?Gly?Val?Phe?Val?Asp?Thr?Gly?Leu?Pro?Asp?Lys?Glu?Ile

85 90 95

Val?ValSer?Leu?Asp?Ile?Leu?Pro?Glu?Leu?Lys?Glu?Leu?Trp?Pro?Lys

100 105 110

Lys?Gly?Asp?Gln?Leu?Tyr?Ile?Arg?Leu?Glu?Val?Asp?Lys?Lys?Asp?Arg

115 120 125

Ile?Trp?Gly?Leu?Leu?Ala?Tyr?Gln?Glu?Asp?Phe?Gln?Arg?Leu?Ala?Arg

130 135 140

Pro?Ala?Tyr?Asn?Asn?Met?Gln?Asn?Gln?Asn?Trp?Pro?Ala?Ile?Val?Tyr

145 150 155 160

Arg?Leu?Lys?Leu?Ser?Gly?Thr?Phe?Val?Tyr?Leu?Pro?Glu?Asn?Asn?Met

165 170 175

Leu?Gly?Phe?Ile?His?Pro?Ser?Glu?Arg?Tyr?Ala?Glu?Pro?Arg?Leu?Gly

180 185 190

Gln?Val?Leu?Asp?Ala?Arg?Val?Ile?Gly?Phe?Arg?Glu?Val?Asp?Arg?Thr

195 200 205

Leu?Asn?Leu?Ser?Leu?Lys?Pro?Arg?Ser?Phe?Glu?Met?Leu?Glu?Asn?Asp

210 215 220

Ala?Gln?Met?Ile?Leu?Thr?Tyr?Leu?Glu?Ser?Asn?Gly?Gly?Phe?Met?Thr

225 230 235 240

Leu?Asn?Asp?Lys?Ser?Ser?Pro?Asp?Asp?Ile?Lys?Ala?Thr?Phe?Gly?Ile

245 250 255

Ser?Lys?Gly?Gln?Phe?Lys?Lys?Ala?Leu?Gly?Gly?Leu?Met?Lys?Ala?Gly

260 265 270

Lys?Ile?Lys?Gln?Asp?Gln?Phe?Gly?Thr?Glu?Leu?Ile

275 280

<210>41

<211>394

<212>PRT

＜213〉streptococcus pneumoniae

<400>41

Met?Lys?Asp?Val?Ser?Leu?Phe?Leu?Leu?Lys?Lys?Val?Phe?Lys?Ser?Arg

1 5 10 15

Leu?Asn?Trp?Ile?Val?Leu?Ala?Leu?Phe?Val?Ser?Val?Leu?Gly?Val?Thr

20 25 30

Phe?Tyr?Leu?Asn?Ser?Gln?Thr?Ala?Asn?Ser?His?Ser?Leu?Glu?Ser?Arg

35 40 45

Leu?Glu?Ser?Arg?Ile?Ala?Ala?Asn?Glu?Arg?Ala?Ile?Asn?Glu?Asn?Glu

50 55 60

Glu?Lys?Leu?Ser?Gln?Met?Ser?Asp?Thr?Ser?Ser?Glu?Glu?Tyr?Gln?Phe

65 70 75 80

Ala?Lys?Asn?Asn?Leu?Asp?Val?Gln?Lys?Asn?Leu?Leu?Thr?Arg?Lys?Thr

85 90 95

Glu?Ile?Leu?Thr?Leu?Leu?Lys?Glu?Gly?Arg?Trp?Lys?Glu?Ala?Tyr?Tyr

100 105 110

Leu?Gln?Trp?Gln?Asp?Glu?Glu?Lys?Asn?Tyr?Glu?Phe?Val?Ser?Asn?Asp

115 120 125

Pro?Thr?Ala?Ser?Pro?Gly?Leu?Lys?Met?Gly?Val?Asp?Arg?Glu?Arg?Lys

130 135 140

Ile?Tyr?Gln?Ala?Leu?Tyr?Pro?Leu?Asn?Ile?Lys?Ala?His?Thr?Leu?Glu

145 150 155 160

Phe?Pro?Thr?His?Gly?Ile?Asp?Gln?Ile?Val?Trp?Ile?Leu?Glu?Val?Ile

165 170 175

Ile?Pro?Ser?Leu?Phe?Val?Val?AIa?Ile?Ile?Phe?Met?Leu?Thr?Gln?Leu

180 185 190

Phe?Ala?Glu?Arg?Tyr?Gln?Asn?His?Leu?Asp?Thr?Ala?His?Leu?Tyr?Pro

195 200 205

Val?Ser?Lys?Val?Thr?Phe?Ala?Ile?Ser?Ser?Leu?Gly?Val?Gly?Val?Gly

210 215 220

Tyr?Val?Thr?Val?Leu?Phe?Ile?Gly?Ile?Cys?Gly?Phe?Ser?Phe?Leu?Val

225 230 235 240

Gly?Ser?Leu?Ile?Ser?Gly?Phe?Gly?Gln?Leu?Asp?Tyr?Pro?Tyr?Pro?Ile

245 250 255

Tyr?Ser?Leu?Val?Asn?Gln?Glu?Val?Thr?Ile?Gly?Lys?Ile?Gln?Asp?Val

260 265 270

Leu?Phe?Pro?Gly?Leu?Leu?Leu?Ala?Phe?Leu?Ala?Phe?Ile?Val?Ile?Val

275 280 285

Glu?Val?Val?Tyr?Leu?Ile?Ala?Tyr?Phe?Phe?Lys?Gln?Lys?Met?Pro?Val

290 295 300

Leu?Phe?Leu?Ser?Leu?Ile?Gly?Ile?Val?Gly?Leu?Leu?Phe?Gly?Ile?Gln

305 310 315 320

Thr?Ile?Gln?Pro?Leu?Gln?Arg?Ile?Ala?His?Leu?Ile?Pro?Phe?Thr?Tyr

325 330 335

Leu?Arg?Ser?Val?Glu?Ile?Leu?Ser?Gly?Arg?Leu?Pro?Lys?Gln?Ile?Asp

340 345 350

Asn?Val?Asp?Leu?Asn?Trp?Ser?Met?Gly?Met?Val?Leu?Leu?Pro?Cys?Leu

355 360 365

Ile?Ile?Phe?Leu?Leu?Leu?Gly?Ile?Leu?Phe?Ile?Glu?Arg?Trp?Gly?Ser

370 375 380

Ser?Gln?Lys?Lys?Glu?Phe?Phe?Asn?Arg?Phe

385 390

<210>42

<211>448

<212>PRT

＜213〉streptococcus pneumoniae

<400>42

Met?Met?Lys?Phe?Ile?Leu?Asp?Ile?Val?Ser?Thr?Pro?Ala?Ile?Leu?Val

1 5 10 15

Ala?Leu?Ile?Ala?Ile?Leu?Gly?Leu?Val?Leu?Gln?Lys?Lys?Lys?Leu?Pro

20 25 30

Asp?Ile?Ile?Lys?Gly?Gly?Ile?Lys?Thr?Phe?Val?Gly?Phe?Leu?Val?Val

35 40 45

Ser?Gly?Gly?Ala?Gly?Ile?Val?Gln?Asn?Ser?Leu?Asn?Pro?Phe?Gly?Thr

50 55 60

Met?Phe?Glu?His?Ala?Phe?His?Leu?Ser?Gly?Val?Val?Pro?Asn?Asn?Glu

65 70 75 80

Ala?Ile?Val?Ala?Val?Ala?Leu?Thr?Thr?Tyr?Gly?Ser?Ala?Thr?Ala?Met

85 90 95

Ile?Met?Phe?Ala?Gly?Met?Val?Phe?Asn?Ile?Leu?Ile?Ala?Arg?Phe?Thr

100 105 110

Arg?Phe?Lys?Tyr?Ile?Phe?Leu?Thr?Gly?His?His?Thr?Leu?Tyr?Met?Ala

115 120 125

Cys?Met?Ile?Ala?Val?Ile?Leu?Ser?Val?Ala?Gly?Phe?Thr?Ser?Leu?Pro

130 135 140

Leu?Ile?Leu?Leu?Gly?Gly?Leu?Ala?Leu?Gly?Ile?Ile?Met?Ser?Ile?Ser

145 150 155 160

Pro?Ala?Phe?Val?Gln?Lys?Tyr?Met?Val?Gln?Leu?Thr?Gly?Asn?Asp?Lys

165 170 175

Val?Ala?Leu?Gly?His?Phe?Ser?Ser?Leu?Gly?Tyr?Trp?Leu?Ser?Gly?Phe

180 185 190

Thr?Gly?Ser?Leu?Ile?Gly?Asp?Lys?Ser?Lys?Ser?Thr?Glu?Asp?Ile?Lys

195 200 205

Phe?Pro?Lys?Ser?Leu?Ala?Phe?Leu?Arg?Asp?Ser?Thr?Val?Ser?Ile?Thr

210 215 220

Leu?Ser?Met?Ala?Val?Ile?Tyr?Ile?Ile?Val?Ala?Ile?Phe?Ala?Gly?Ser

225 230 235 240

Glu?Tyr?Ile?Glu?Lys?Glu?Ile?Ser?Ser?Gly?Thr?Ser?Gly?Leu?Val?Tyr

245 250 255

Ala?Leu?Gln?Leu?Ala?Gly?Gln?Phe?Ala?Ala?Gly?Val?Phe?Val?Ile?Leu

260 265 270

Ala?Gly?Val?Arg?Leu?Ile?Leu?Gly?Glu?Ile?Val?Pro?Ala?Phe?Lys?Gly

275 280 285

Ile?Ser?Glu?Arg?Leu?Val?Pro?Asn?Ser?Lys?Pro?Ala?Leu?Asp?Cys?Pro

290 295 300

Ile?Val?Tyr?Thr?Tyr?Ala?Pro?Asn?Ala?Val?Leu?Ile?Gly?Phe?Ile?Ser

305 310 315 320

Ser?Phe?Val?Gly?Gly?Leu?Val?Ser?Met?Val?Ile?Met?Ile?Ala?Ser?Gly

325 330 335

Thr?Val?Val?Ile?Leu?Pro?Gly?Val?Val?Pro?His?Phe?Phe?Cys?Gly?Ala

340 345 350

Thr?Ala?Gly?Val?Ile?Gly?Asn?Ala?Ser?Gly?Gly?Val?Arg?Gly?Ala?Thr

355 360 365

Ile?Gly?Ala?Phe?Leu?Gln?Gly?Ile?Leu?Ile?Ser?Phe?Leu?Pro?Val?Phe

370 375 380

Leu?Met?Pro?Val?Leu?Gly?Gly?Leu?Gly?Phe?Gln?Gly?Ser?Thr?Phe?Ser

385 390 395 400

Asp?Ala?Asp?Phe?Gly?Leu?Ser?Gly?Ile?Ile?Leu?Gly?Met?Leu?Asn?Gln

405 410 415

Phe?Gly?Ser?Gln?Ala?Gly?Ile?Val?Ile?Gly?Leu?Val?Leu?Ile?Leu?Ala

420 425 430

Val?Met?Phe?Gly?Val?Ser?Phe?Ile?Lys?Lys?Pro?Ser?Ala?Thr?Glu?Glu

435 440 445

<210>43

<211>333

<212>PRT

＜213〉streptococcus pneumoniae

<400>43

Met?Ile?Lys?Thr?Phe?Leu?Ser?Ala?Leu?Ser?Val?Ile?Leu?Phe?Ser?Ile

1 5 10 15

Pro?Ile?Ile?Thr?Tyr?Ser?Phe?Phe?Pro?Ser?Ser?Asn?Leu?Asn?Ile?Trp

20 25 30

Leu?Ser?Thr?Gln?Pro?Ile?Leu?Ala?Gln?Ile?Tyr?Ala?Phe?Pro?Leu?Ala

35 40 45

Thr?Ala?Thr?Met?Ala?Ala?Ile?Leu?Ser?Phe?Leu?Phe?Phe?Phe?Leu?Ser

50 55 60

Phe?Tyr?Lys?Lys?Asn?Lys?Gln?Ile?Arg?Phe?Tyr?Ser?Gly?Ile?Leu?Leu

65 70 75 80

Leu?Leu?Ser?Leu?Ile?Leu?Leu?Leu?Phe?Gly?Thr?Asp?Lys?Thr?Leu?Ser

85 90 95

Ser?Ala?Ser?Asn?Lys?Thr?Lys?Thr?Leu?Lys?Leu?Val?Thr?Trp?Asn?Val

100 105 110

Ala?Asn?Gln?Ile?Glu?Ala?Gln?His?Ile?Glu?Arg?Ile?Phe?Ser?His?Phe

115 120 125

Asp?Ala?Asp?Met?Ala?Ile?Phe?Pro?Glu?Leu?Ala?Thr?Asn?Ile?Arg?Gly

130 135 140

Glu?Gln?Glu?Asn?Gln?Arg?Ile?Lys?Leu?Leu?Phe?His?Gln?Val?Gly?Leu

145 150 155 160

Ser?Met?Ala?Asn?Tyr?Asp?Ile?Phe?Thr?Ser?Pro?Pro?Thr?Asn?Ser?Gly

165 170 175

Ile?Ala?Pro?Val?Thr?Val?Ile?Val?Lys?Lys?Ser?Tyr?Gly?Phe?Tyr?Thr

180 185 190

Glu?Ala?Lys?Thr?Phe?His?Thr?Thr?Arg?Phe?Gly?Thr?Ile?Val?Leu?His

195 200 205

Ser?Arg?Lys?Gln?Asn?Ile?Pro?Asp?Ile?Ile?Ala?Leu?His?Thr?Ala?Pro

210 215 220

Pro?Leu?Pro?Gly?Leu?Met?Glu?Ile?Trp?Lys?Gln?Asp?Leu?Asn?Ile?Ile

225 230 235 240

His?Asn?Gln?Leu?Ala?Ser?Lys?Tyr?Pro?Lys?Ala?Ile?Ile?Ala?Gly?Asp

245 250 255

Phe?Asn?Ala?Thr?Met?Arg?His?Gly?Ala?Leu?Ala?Lys?Ile?Ser?Ser?His

260 265 270

Arg?Asp?Ala?Leu?Asn?Ala?Leu?Pro?Pro?Phe?Glu?Arg?Gly?Thr?Trp?Asn

275 280 285

Ser?Gln?Ser?Pro?Lys?Leu?Phe?Asn?Ala?Thr?Ile?Asp?His?Ile?Leu?Leu

290 295 300

Pro?Lys?Asn?His?Tyr?Tyr?Val?Lys?Asp?Leu?Asp?Ile?Val?Ser?Phe?Gln

305 310 315 320

Asn?Ser?Asp?His?Arg?Cys?Ile?Phe?Thr?Glu?Ile?Thr?Phe

325 330

<210>44

<211>425

<212>PRT

＜213〉streptococcus pneumoniae

<400>44

Met?Asn?Pro?Ile?Gln?Arg?Ser?Trp?Ala?Tyr?Val?Ser?Arg?Lys?Arg?Leu

1 5 10 15

Arg?Ser?Phe?Ile?Leu?Phe?Leu?Ile?Leu?Leu?Val?Leu?Leu?Ala?Gly?Ile

20 25 30

Ser?Ala?Cys?Leu?Thr?Leu?Met?Lys?Ser?Asn?Lys?Thr?Val?Glu?Ser?Asn

35 40 45

Leu?Tyr?Lys?Ser?Leu?Asn?Thr?Ser?Phe?Ser?Ile?Lys?Lys?Ile?Glu?Asn

50 55 60

Gly?Gln?Thr?Phe?Lys?Leu?Ser?Asp?Leu?Ala?Ser?Val?Ser?Lys?Ile?Lys

65 70 75 80

Gly?Leu?Glu?Asn?Val?Ser?Pro?Glu?Leu?Glu?Thr?Val?Ala?Lys?Leu?Lys

85 90 95

Asp?Lys?Glu?Ala?Val?Thr?Gly?Glu?Gln?Ser?Val?Glu?Arg?Asp?Asp?Leu

100 105 110

Ser?Ala?Ala?Asp?Asn?Asn?Leu?Val?Ser?Leu?Thr?Ala?Leu?Glu?Asp?Ser

115 120 125

Ser?Lys?Asp?Val?Thr?Phe?Thr?Ser?Ser?Ala?Phe?Asn?Leu?Lys?Glu?Gly

130 135 140

Arg?His?Leu?Gln?Lys?Gly?Asp?Ser?Lys?Lys?Ile?Leu?Ile?His?Glu?Glu

145 150 155 160

Leu?Ala?Lys?Lys?Asn?Gly?Leu?Ser?Leu?His?Asp?Lys?Ile?Gly?Leu?Asp

165 170 175

Ala?Gly?Gln?Ser?Glu?Ser?Gly?Lys?Gly?Gln?Thr?Val?Glu?Phe?Glu?Ile

180 185 190

Ile?Gly?Ile?Phe?Ser?Gly?Lys?Lys?Gln?Glu?Lys?Phe?Thr?Gly?Leu?Ser

195 200 205

Ser?Asp?Phe?Ser?Glu?Asn?Gln?Val?Phe?Thr?Asp?Tyr?Glu?Ser?Ser?Gln

210 215 220

Thr?Leu?Leu?Gly?Asn?Ser?Glu?Ala?Gln?Val?Ser?Ala?Ala?Arg?Phe?Tyr

225 230 235 240

Val?Glu?Asn?Pro?Lys?Glu?Met?Asp?Gly?Leu?Met?Lys?Gln?Val?Glu?Asn

245 250 255

Leu?Ala?Leu?Glu?Asn?Gln?Gly?Tyr?Gln?Val?Glu?Lys?Glu?Asn?Lys?Ala

260 265 270

Phe?Glu?Gln?Ile?Lys?Asp?Ser?Val?Ala?Thr?Phe?Gln?Thr?Phe?Leu?Thr

275 280 285

Ile?Phe?Leu?Tyr?Gly?Met?Leu?Ile?Ala?Gly?Ala?Gly?Ala?Leu?Ile?Leu

290 295 300

Val?Leu?Ser?Leu?Trp?Leu?Arg?Glu?Arg?Val?Tyr?Glu?Val?Gly?Ile?Leu

305 310 315 320

Leu?Ala?Leu?Gly?Lys?Gly?Lys?Ser?Ser?Ile?Phe?Leu?Gln?Phe?Cys?Leu

325 330 335

Glu?Val?Val?Leu?Val?Ser?Leu?Gly?Ala?Leu?Leu?Pro?Ala?Phe?Val?Ala

340 345 350

Gly?Asn?Ala?Ile?Thr?Thr?Tyr?Leu?Leu?Gln?Thr?Leu?Leu?Ala?Ser?Gly

355 360 365

Asp?Gln?Ala?Ser?Leu?Gln?Asp?Thr?Leu?Ala?Lys?Ala?Ser?Ser?Leu?Ser

370 375 380

Thr?Ser?Ile?Leu?Ser?Phe?Ala?Glu?Ser?Tyr?Val?Phe?Leu?Val?Leu?Leu

385 390 395 400

Ser?Cys?Leu?Ser?Val?Ala?Leu?Cys?Phe?Leu?Phe?Leu?Phe?Arg?Lys?Ser

405 410 415

Pro?Lys?Glu?Ile?Leu?Ser?Ser?Ile?Ser

420 425

<210>45

<211>459

<212>PRT

＜213〉streptococcus pneumoniae

<400>45

Met?Leu?His?Asn?Ala?Phe?Ala?Tyr?Val?Thr?Arg?Lys?Phe?Phe?Lys?Ser

1 5 10 15

Ile?Val?Ile?Phe?Leu?Ile?Ile?Leu?Leu?Met?Ala?Ser?Leu?Ser?Leu?Val

20 25 30

Gly?Leu?Ser?Ile?Lys?Gly?Ala?Thr?Ala?Lys?Ala?Ser?Gln?Glu?Thr?Phe

35 40 45

Lys?Asn?Ile?Thr?Asn?Ser?Phe?Ser?Met?Gln?Ile?Asn?Arg?Arg?Val?Asn

50 55 60

Gln?Gly?Thr?Pro?Arg?Gly?Ala?Gly?Asn?Ile?Lys?Gly?Glu?Asp?Ile?Lys

65 70 75 80

Lys?Ile?Thr?Glu?Asn?Lys?Ala?Ile?Glu?Ser?Tyr?Val?Lys?Arg?Ile?Asn

85 90 95

Ala?Ile?Gly?Asp?Leu?Thr?Gly?Tyr?Asp?Leu?Ile?Glu?Thr?Pro?Glu?Thr

100 105 110

Lys?Lys?Asn?Leu?Thr?Ala?Asp?Arg?Ala?Lys?Arg?Phe?Gly?Ser?Ser?Leu

115 120 125

Met?Ile?Thr?Gly?Val?Asn?Asp?Ser?Ser?Lys?Glu?Asp?Lys?Phe?Val?Ser

130 135 140

Gly?Ser?Tyr?Lys?Leu?Val?Glu?Gly?Glu?His?Leu?Thr?Asn?Asp?Asp?Lys

145 150 155 160

Asp?Lys?Ile?Leu?Leu?His?Lys?Asp?Leu?Ala?Ala?Lys?His?Gly?Trp?Lys

165 170 175

Val?Gly?Asp?Lys?Val?Lys?Leu?Asp?Ser?Asn?Ile?Tyr?Asp?Ala?Asp?Asn

180 185 190

Glu?Lys?Gly?Ala?Lys?Glu?Thr?Val?Glu?Val?Thr?Ile?Lys?Gly?Leu?Phe

195 200 205

Asp?Gly?His?Asn?Lys?Ser?Ala?Val?Thr?Tyr?Ser?Gln?Glu?Leu?Tyr?Glu

210 215 220

Asn?Thr?Ala?Ile?Thr?Asp?Ile?His?Thr?Ala?Ala?Lys?Leu?Tyr?Gly?Tyr

225 230 235 240

Thr?Glu?Asp?Thr?Ala?Ile?Tyr?Gly?Asp?Ala?Thr?Phe?Phe?Val?Thr?Ala

245 250 255

Asp?Lys?Asn?Leu?Asp?Asp?Val?Met?Lys?Glu?Leu?Asn?Gly?Ile?Ser?Gly

260 265 270

Ile?Asn?Trp?Lys?Ser?Tyr?Thr?Leu?Val?Lys?Ser?Ser?Ser?Asn?Tyr?Pro

275 280 285

Ala?Leu?Glu?Gln?Ser?Ile?Ser?Gly?Met?Tyr?Lys?Met?Ala?Asn?Leu?Leu

290 295 300

Phe?Trp?Gly?Ser?Leu?Ser?Phe?Ser?Val?Leu?Leu?Leu?Ala?Leu?Leu?Leu

305 310 315 320

Ser?Leu?Trp?Ile?Asn?Ala?Arg?Arg?Lys?Glu?Val?Gly?Ile?Leu?Leu?Ser

325 330 335

Ile?Gly?Leu?Lys?Gln?Ala?Ser?Ile?Leu?Gly?Gln?Phe?Ile?Thr?Glu?Ser

340 345 350

Ile?Leu?Ile?Ala?Ile?Pro?Ala?Leu?Val?Ser?Ala?Tyr?Phe?Leu?Ala?Asn

355 360 365

Tyr?Thr?Ala?Arg?Ala?Ile?Gly?Asn?Thr?Val?Leu?Ala?Asn?Val?Thr?Ser

370 375 380

Gly?Val?Ala?Lys?Gln?Ala?Ser?Lys?Ala?Ala?Gln?Ala?Ser?Asn?Leu?Gly

385 390 395 400

Gly?Gly?Ala?Glu?Val?Asp?Gly?Phe?Ser?Lys?Thr?Leu?Ser?Ser?Leu?Asp

405 410 415

Ile?Ser?Ile?Gln?Thr?Ser?Asp?Phe?Ile?Ile?Ile?Phe?Val?Leu?Ala?Leu

420 425 430

Val?Leu?Val?Val?Leu?Val?Met?Ala?Leu?Ala?Ser?Ser?Asn?Leu?Leu?Arg

435 440 445

Lys?Gln?Pro?Lys?Glu?Leu?Leu?Leu?Asp?Gly?Glu

450 455

<210>46

<211>205

<212>PRT

＜213〉streptococcus pneumoniae

<400>46

Met?Ser?Gln?Asp?Lys?Gln?Met?Lys?Ala?Val?Ser?Pro?Leu?Leu?Gln?Arg

1 5 10 15

Val?Ile?Asn?Ile?Ser?Ser?Ile?Val?Gly?Gly?Val?Gly?Ser?Leu?Ile?Phe

20 25 30

Cys?Ile?Trp?Ala?Tyr?Gln?Ala?Gly?Ile?Leu?Gln?Ser?Lys?Glu?Thr?Leu

35 40 45

Ser?Ala?Phe?Ile?Gln?Gln?Ala?Gly?Ile?Trp?Gly?Pro?Pro?Leu?Phe?Ile

50 55 60

Phe?Leu?Gln?Ile?Leu?Gln?Thr?Val?Val?Pro?Ile?Ile?Pro?Gly?Ala?Leu

65 70 75 80

Thr?Ser?Val?Ala?Gly?Val?Phe?Ile?Tyr?Gly?His?Ile?Ile?Gly?Thr?Ile

85 90 95

Tyr?Asn?Tyr?Ile?Gly?Ile?Val?Ile?Gly?Cys?Ala?Ile?Ile?Phe?Tyr?Leu

100 105 110

Val?Arg?Leu?Tyr?Gly?Ala?Ala?Phe?Val?Gln?Ser?Val?Val?Ser?Lys?Arg

115 120 125

Thr?Tyr?Asp?Lys?Tyr?Ile?Asp?Trp?Leu?Asp?Lys?Gly?Asn?Arg?Phe?Asp

130 135 140

Arg?Phe?Phe?Ile?Phe?Met?Met?Ile?Trp?Pro?Ile?Ser?Pro?Ala?Asp?Phe

145 150 155 160

Leu?Cys?Met?Leu?Ala?Ala?Leu?Thr?Lys?Met?Ser?Phe?Lys?Arg?Tyr?Met

165 170 175

Thr?Ile?Ile?Ile?Leu?Thr?Lys?Pro?Phe?Thr?Leu?Val?Val?Tyr?Thr?Tyr

180 185 190

Gly?Leu?Thr?Tyr?Ile?Ile?Asp?Phe?Phe?Trp?Gln?Met?Leu

195 200 205

<210>47

<211>399

<212>PRT

＜213〉streptococcus pneumoniae

<400>47

Met?Arg?Asn?Met?Trp?Val?Val?Ile?Lys?Glu?Thr?Tyr?Leu?Arg?His?Val

1 5 10 15

Glu?Ser?Trp?Ser?Phe?Phe?Phe?Met?Val?Ile?Ser?Pro?Phe?Leu?Phe?Leu

20 25 30

Gly?Ile?Ser?Val?Gly?Ile?Gly?His?Leu?Gln?Gly?Ser?Ser?Met?Ala?Lys

35 40 45

Asn?Asn?Lys?Val?Ala?Val?Val?Thr?Thr?Val?Pro?Ser?Val?Ala?Glu?Gly

50 55 60

Leu?Lys?Asn?Val?Asn?Gly?Val?Asn?Phe?Asp?Tyr?Lys?Asp?Glu?Ala?Ser

65 70 75 80

Ala?Lys?Glu?Ala?Ile?Lys?Glu?Glu?Lys?Leu?Lys?Gly?Tyr?Leu?Thr?Ile

85 90 95

Asp?Gln?Glu?Asp?Ser?Val?Leu?Lys?Ala?Val?Tyr?His?Gly?Glu?Thr?Ser

100 105 110

Leu?Glu?Asn?Gly?Ile?Lys?Phe?Glu?Val?Thr?Gly?Thr?Leu?Asn?Glu?Leu

115 120 125

Gln?Asn?Gln?Leu?Asn?Arg?Ser?Thr?Ala?Ser?Leu?Ser?Gln?Glu?Gln?Glu

130 135 140

Lys?Arg?Leu?Ala?Gln?Thr?Ile?Gln?Phe?Thr?Glu?Lys?Ile?Asp?Glu?Ala

145 150 155 160

Lys?Glu?Asn?Lys?Lys?Phe?Ile?Gln?Thr?Ile?Ala?Ala?Gly?Ala?Leu?Gly

165 170 175

Phe?Phe?Leu?Tyr?Met?Ile?Leu?Ile?Thr?Tyr?Ala?Gly?Val?Thr?Ala?Gln

180 185 190

Glu?Val?Ala?Ser?Glu?Lys?Gly?Thr?Lys?Ile?Met?Glu?Val?Val?Phe?Ser

195 200 205

Ser?Ile?Arg?Ala?Ser?His?Tyr?Phe?Tyr?Ala?Arg?Met?Met?Ala?Leu?Phe

210 215 220

Leu?Val?Ile?Leu?Thr?His?Ile?Gly?Ile?Tyr?Val?Val?Gly?Gly?Leu?Ala

225 230 235 240

Ala?Val?Leu?Leu?Phe?Lys?Asp?Leu?Pro?Phe?Leu?Ala?Gln?Ser?Gly?Ile

245 250 255

Leu?Asp?His?Leu?Gly?Asp?Ala?Ile?Ser?Leu?Asn?Thr?Leu?Leu?Phe?Ile

260 265 270

Leu?Ile?Ser?Leu?Phe?Met?Tyr?Val?Val?Leu?Ala?Ala?Phe?Leu?Gly?Ser

275 280 285

Met?Val?Ser?Arg?Pro?Glu?Asp?Ser?Gly?Lys?Ala?Leu?Ser?Pro?Leu?Met

290 295 300

Ile?Leu?Ile?Met?Gly?Gly?Phe?Phe?Gly?Val?Thr?Ala?Leu?Gly?Ala?Ala

305 310 315 320

Gly?Asp?Asn?Leu?Leu?Leu?Lys?Ile?Gly?Ser?Tyr?Ile?Pro?Phe?Ile?Ser

325 330 335

Thr?Phe?Phe?Met?Pro?Phe?Arg?Thr?Ile?Asn?Asp?Tyr?Ala?Gly?Gly?Ala

Glu?Ala?Trp?Ile?Ser?Leu?Ala?Ile?Thr?Val?Ile?Phe?Ala?Val?Val?Ala

355 360 365

Thr?Gly?Phe?Ile?Gly?Arg?Met?Tyr?Ala?Ser?Leu?Val?Leu?Gln?Thr?Asp

370 375 380

Asp?Leu?Gly?Ile?Trp?Lys?Thr?Phe?Lys?Arg?Ala?Leu?Ser?Tyr?Lys

385 390 395

<210>48

<211>438

<212>PRT

＜213〉streptococcus pneumoniae

<400>48

Met?Thr?Glu?Thr?Ile?Lys?Leu?Met?Lys?Ala?His?Thr?Ser?Val?Arg?Arg

1 5 10 15

Phe?Lys?Glu?Gln?Glu?Ile?Pro?Gln?Val?Asp?Leu?Asn?Glu?Ile?Leu?Thr

20 25 30

Ala?Ala?Gln?Met?Ala?Ser?Ser?Trp?Lys?Asn?Phe?Gln?Ser?Tyr?Ser?Val

35 40 45

Ile?Val?Val?Arg?Ser?Gln?Glu?Lys?Lys?Asp?Ala?Leu?Tyr?Glu?Leu?Val

50 55 60

Pro?Gln?Glu?Ala?Ile?Arg?Gln?Ser?Ala?Val?Phe?Leu?Leu?Phe?Val?Gly

65 70 75 80

Asp?Leu?Asn?Arg?Ala?Glu?Lys?Gly?Ala?Arg?Leu?His?Thr?Asp?Thr?Phe

85 90 95

Gln?Pro?Gln?Gly?Val?Glu?Gly?Leu?Leu?Ile?Ser?Ser?Val?Asp?Ala?Ala

100 105 110

Leu?Ala?Gly?Gln?Asn?Ala?Leu?Leu?Ala?Ala?Glu?Ser?Leu?Gly?Tyr?Gly

115 120 125

Gly?Val?Ile?Ile?Gly?Leu?Val?Arg?Tyr?Lys?Ser?Glu?Glu?Val?Ala?Glu

130 135 140

Leu?Phe?Asn?Leu?Pro?Asp?Tyr?Thr?Tyr?Ser?Val?Phe?Gly?Met?Ala?Leu

145 150 155 160

Gly?Val?Pro?Asn?Gln?His?His?Asp?Met?Lys?Pro?Arg?Leu?Pro?Leu?Glu

165 170 175

Asn?Val?Val?Phe?Glu?Glu?Glu?Tyr?Gln?Glu?Gln?Ser?Thr?Glu?Ala?Ile

180 185 190

Gln?Ala?Tyr?Asp?Arg?Val?Gln?Ala?Asp?Tyr?Ala?Gly?Ala?Arg?Ala?Thr

195 200 205

Thr?Ser?Trp?Ser?Gln?Arg?Leu?Ala?Glu?Gln?Phe?Gly?Gln?Ala?Glu?Pro

210 215 220

Ser?Ser?Thr?Arg?Lys?Asn?Leu?Glu?Gln?Lys?Lys?Leu?Leu?Met?Leu?Lys

225 230 235 240

Leu?Ile?Ala?Ile?Val?Gly?Thr?Asn?Ser?Lys?Arg?Ser?Thr?Asn?Arg?Gln

245 250 255

Leu?Leu?Gln?Tyr?Met?Gln?Lys?His?Phe?Thr?Asp?Lys?Ala?Glu?Ile?Glu

260 265 270

Leu?Val?Glu?Ile?Lys?Ala?IIe?Pro?Val?Phe?Asn?Lys?Pro?Ala?Asp?Lys

275 280 285

Gln?Val?Pro?Ala?Glu?Ile?Leu?Glu?Ile?Ala?Ala?Lys?Ile?Glu?Glu?Ala

290 295 300

Asp?Gly?Val?Ile?Ile?Gly?Thr?Pro?Glu?Tyr?Asp?His?Ser?Ile?Pro?Ala

305 310 315 320

Val?Leu?Met?Ser?Ala?Leu?Ala?Trp?Leu?Ser?Tyr?Gly?Ile?Tyr?Pro?Leu

325 330 335

Leu?Asn?Lys?Pro?Ile?Met?Ile?Thr?Gly?Ala?Ser?Tyr?Gly?Thr?Leu?Gly

340 345 350

Ser?Ser?Arg?Ala?Gln?Leu?Gln?Leu?Arg?Gln?Ile?Leu?Asn?Ala?Pro?Glu

355 360 365

Ile?Lys?Ala?Asn?Val?Leu?Pro?Asp?Glu?Phe?Leu?Leu?Ser?His?Ser?Leu

370 375 380

Gln?Ala?Phe?Asn?Pro?Ser?Gly?Asp?Leu?Val?Asp?Leu?Asp?Val?Ile?Lys

385 390 395 400

Lys?Leu?Asp?Ala?Ile?Phe?Asp?Asp?Phe?Arg?Ile?Phe?Val?Lys?Ile?Thr

405 410 415

Glu?Lys?Leu?Arg?Asn?Ala?Gln?Glu?Leu?Leu?Arg?Lys?Asp?Ala?Glu?Asp

420 425 430

Phe?Asp?Trp?Glu?Asn?Leu

435

<210>49

<211>280

<212>PRT

＜213〉streptococcus pneumoniae

<400>49

Met?Asn?Thr?Tyr?Gln?Leu?Asn?Asn?Gly?Val?Glu?Ile?Pro?Val?Leu?Gly

1 5 10 15

Phe?Gly?Thr?Phe?Lys?Ala?Lys?Asp?Gly?Glu?Glu?Ala?Tyr?Arg?Ala?Val

20 25 30

Leu?Glu?Ala?Leu?Lys?Ala?Gly?Tyr?Arg?His?Ile?Asp?Thr?Ala?Ala?Ile

35 40 45

Tyr?Gln?Asn?Glu?Glu?Ser?Val?Gly?Gln?Ala?Ile?Lys?Asp?Ser?Gly?Val

50 55 60

Pro?Arg?Glu?Glu?Met?Phe?Val?Thr?Thr?Lys?Leu?Trp?Asn?Ser?Gln?Gln

65 70 75 80

Thr?Tyr?Glu?Gln?Thr?Arg?Gln?Ala?Leu?Glu?Lys?Ser?Ile?Glu?Lys?Leu

85 90 95

Gly?Leu?Asp?Tyr?Leu?Asp?Leu?Tyr?Leu?Ile?His?Trp?Pro?Asn?Pro?Lys

100 105 110

Pro?Leu?Arg?Glu?Asn?Asp?Ala?Trp?Lys?Thr?Arg?Asn?Ala?Glu?Val?Trp

115 120 125

Arg?Ala?Met?Glu?Asp?Leu?Tyr?Gln?Glu?Gly?Lys?Ile?Arg?Ala?Ile?Gly

130 135 140

Val?Ser?Asn?Phe?Leu?Pro?His?His?Leu?Asp?Ala?Leu?Leu?Glu?Thr?Ala

145 150 155 160

Thr?Ile?Val?Pro?Ala?Val?Asn?Gln?Val?Arg?Leu?Ala?Pro?Gly?Val?Tyr

165 170 175

Gln?Asp?Gln?Val?Val?Ala?Tyr?Cys?Arg?Glu?Lys?Gly?Ile?Leu?Leu?Glu

180 185 190

Ala?Trp?Gly?Pro?Phe?Gly?Gln?Gly?Glu?Leu?Phe?Asp?Ser?Lys?Gln?Val

195 200 205

Gln?Glu?Ile?Ala?Ala?Asn?His?Gly?Lys?Ser?Val?Ala?Gln?Ile?Ala?Leu

210 215 220

Ala?Trp?Ser?Leu?Ala?Glu?Gly?Phe?Leu?Pro?Leu?Pro?Lys?Ser?Val?Thr

225 230 235 240

Thr?Ser?Arg?Ile?Gln?Ala?Asn?Leu?Asp?Cys?Phe?Gly?Ile?Glu?Leu?Ser

245 250 255

His?Glu?Glu?Arg?Glu?Thr?Leu?Lys?Thr?Ile?Ala?Val?Gln?Ser?Gly?Ala

260 265 270

Pro?Arg?Val?Asp?Asp?Val?Asp?Phe

275 280

<210>50

<211>266

<212>PRT

＜213〉streptococcus pneumoniae

<400>50

Met?Arg?Cys?Lys?Met?Leu?Asp?Pro?Ile?Ala?Ile?Gln?Leu?Gly?Pro?Leu

1 5 10 15

Ala?Ile?Arg?Trp?Tyr?Ala?Leu?Cys?Ile?Val?Thr?Gly?Leu?Ile?Leu?Ala

20 25 30

Val?Tyr?Leu?Thr?Met?Lys?Glu?Ala?Pro?Arg?Lys?Lys?Ile?Ile?Pro?Asp

35 40 45

Asp?Ile?Leu?Asp?Phe?Ile?Leu?Val?Ala?Phe?Pro?Leu?Ala?Ile?Leu?Gly

50 55 60

Ala?Arg?Leu?Tyr?Tyr?Val?Ile?Phe?Arg?Phe?Asp?Tyr?Tyr?Ser?Gln?Asn

65 70 75 80

Leu?Gly?Glu?Ile?Phe?Ala?Ile?Trp?Asn?Gly?Gly?Leu?Ala?Ile?Tyr?Gly

85 90 95

Gly?Leu?Ile?Thr?Gly?Ala?Leu?Val?Leu?Tyr?Ile?Phe?Ala?Asp?Arg?Lys

100 105 110

Leu?Ile?Asn?Thr?Trp?Asp?Phe?Leu?Asp?Ile?Ala?Ala?Pro?Ser?Val?Met

115 120 125

Ile?Ala?Gln?Ser?Leu?Gly?Arg?Trp?Gly?Asn?Phe?Phe?Asn?Gln?Glu?Ala

130 135 140

Tyr?Gly?Ala?Thr?Val?Asp?Asn?Leu?Asp?Tyr?Leu?Pro?Gly?Phe?Ile?Arg

145 150 155 160

Asp?Gln?Met?Tyr?Ile?Glu?Gly?Ser?Tyr?Arg?Gln?Pro?Thr?Phe?Leu?Tyr

165 170 175

Glu?Ser?Leu?Trp?Asn?Leu?Leu?Gly?Phe?Ala?Leu?Ile?Leu?Ile?Phe?Arg

180 185 190

Arg?Lys?Trp?Lys?Ser?Leu?Arg?Arg?Gly?His?Ile?Thr?Ala?Phe?Tyr?Leu

195 200 205

Ile?Trp?Tyr?Gly?Phe?Gly?Arg?Met?Val?Ile?Glu?Gly?Met?Arg?Thr?Asp

210 215 220

Ser?Leu?Met?Phe?Phe?Gly?Phe?Arg?Val?Ser?Gln?Trp?Leu?Ser?Val?Val

225 230 235 240

Leu?Ile?Gly?Leu?Gly?Ile?Met?Ile?Val?Ile?Tyr?Gln?Asn?Arg?Lys?Lys

245 250 255

Ala?Pro?Tyr?Tyr?Ile?Thr?Glu?Glu?Glu?Asn

260 265

<210>51

<211>129

<212>PRT

＜213〉streptococcus pneumoniae

<400>51

Met?Gly?Lys?Leu?Ser?Ser?Ile?Leu?Leu?Gly?Thr?Val?Ser?Gly?Ala?Ala

1 5 10 15

Leu?Ala?Leu?Phe?Leu?Thr?Ser?Asp?Lys?Gly?Lys?Gln?Val?Cys?Ser?Gln

20 25 30

Ala?Gln?Asp?Phe?Leu?Asp?Asp?Leu?Arg?Glu?Asp?Pro?Glu?Tyr?Ala?Lys

35 40 45

Glu?Gln?Val?Cys?Glu?Lys?Leu?Thr?Glu?Val?Lys?Glu?Gln?Ala?Thr?Asp

50 55 60

Phe?Val?Leu?Lys?Thr?Lys?Glu?Gln?Val?Glu?Ser?Gly?Glu?Ile?Thr?Val

65 70 75 80

Asp?Ser?Ile?Leu?Ala?Gln?Thr?Lys?Ser?Tyr?Ala?Phe?Gln?Ala?Thr?Glu

85 90 95

Ala?Ser?Lys?Asn?Gln?Leu?Asn?Asn?Leu?Lys?Glu?Gln?Trp?Gln?Glu?Lys

100 105 110

Ala?Glu?Ala?Leu?Asp?Asp?Ser?Glu?Glu?Ile?Val?Ile?Asp?Ile?Thr?Glu

115 120 125

Glu

<210>52

<211>205

<212>PRT

＜213〉streptococcus pneumoniae

<400>52

Met?Lys?Thr?Lys?Leu?Ile?Phe?Trp?Gly?Ser?Met?Leu?Phe?Leu?Leu?Ser

1 5 10 15

Leu?Ser?Ile?Leu?Leu?Thr?Ile?Tyr?Leu?Ala?Trp?Ile?Phe?Tyr?Pro?Met

20 25 30

Glu?Ile?Gln?Trp?Leu?Asn?Leu?Thr?Asn?Arg?Val?Tyr?Leu?Lys?Pro?Glu

35 40 45

Thr?Ile?Gln?Tyr?Asn?Phe?His?Ile?Leu?Met?Asn?Tyr?Leu?Thr?Asn?Pro

50 55 60

Phe?Ser?Gln?Val?Leu?Gln?Met?Pro?Asp?Phe?Arg?Ser?Ser?Ala?Ala?Gly

65 70 75 80

Leu?His?His?Phe?Ala?Val?Val?Lys?Asn?Leu?Phe?His?Leu?Val?Gln?Leu

85 90 95

Val?Ala?Leu?Val?Thr?Leu?Pro?Ser?Phe?Tyr?Val?Phe?Val?Asn?Arg?Ile

100 105 110

Val?Lys?Lys?Asp?Phe?Leu?Ser?Leu?Tyr?Arg?Lys?Ser?Leu?Leu?Ala?Leu

115 120 125

Val?Val?Leu?Pro?Val?Met?Ile?Gly?Leu?Gly?Gly?Val?Leu?Ile?Gly?Phe

130 135 140

Asp?Gln?Phe?Phe?Thr?Leu?Phe?His?Gln?Ile?Leu?Phe?Val?Gly?Asp?Asp

145 150 155 160

Thr?Trp?Leu?Phe?Asp?Pro?Ala?Lys?Asp?Pro?Val?Ile?Met?Ile?Leu?Pro

165 170 175

Glu?Thr?Phe?Phe?Leu?His?Ala?Phe?Leu?Leu?Phe?Phe?Ala?Leu?Tyr?Glu

180 185 190

Asn?Phe?Phe?Gly?Tyr?Leu?Tyr?Leu?Lys?Ser?Arg?Arg?Lys

195 200 205

<210>53

<211>637

<212>PRT

＜213〉streptococcus pneumoniae

<400>53

Met?Thr?Tyr?His?Phe?Thr?Glu?Glu?Tyr?Asp?Ile?Ile?Val?Ile?Gly?Ala

1 5 10 15

Gly?His?Ala?Gly?Val?Glu?Ala?Ser?Leu?Ala?Ala?Ser?Arg?Met?Gly?Cys

20 25 30

Lys?Val?Leu?Leu?Ala?Thr?Ile?Asn?Ile?Glu?Met?Leu?Ala?Phe?Met?Pro

35 40 45

Cys?Asn?Pro?Ser?Ile?Gly?Gly?Ser?Ala?Lys?Gly?Ile?Val?Val?Arg?Glu

50 55 60

Val?Asp?Ala?Leu?Gly?Gly?Glu?Met?Ala?Lys?Thr?Ile?Asp?Lys?Thr?Tyr

65 70 75 80

Ile?Gln?Met?Lys?Met?Leu?Asn?Thr?Gly?Lys?Gly?Pro?Ala?Val?Arg?Ala

85 90 95

Leu?Arg?Ala?Gln?Ala?Asp?Lys?Glu?Leu?Tyr?Ser?Lys?Glu?Met?Arg?Lys

100 105 110

Thr?Val?Glu?Asn?Gln?Glu?Asn?Leu?Thr?Leu?Arg?Gln?Thr?Met?Ile?Asp

115 120 125

Glu?Ile?Leu?Val?Glu?Asp?Gly?Lys?Val?Val?Gly?Val?Arg?Thr?Ala?Thr

130 135 140

His?Gln?Glu?Tyr?Ala?Ala?Lys?Ala?Val?Ile?Val?Thr?Thr?Gly?Thr?Ala

145 150 155 160

Leu?Arg?Gly?Glu?Ile?Ile?Ile?Gly?Asp?Leu?Lys?Tyr?Ser?Ser?Gly?Pro

165 170 175

Asn?His?Ser?Leu?Ala?Ser?Ile?Asn?Leu?Ala?Asp?Asn?Leu?Lys?Glu?Leu

180 185 190

Gly?Leu?Glu?Ile?Gly?Arg?Phe?Lys?Thr?Gly?Thr?Pro?Pro?Arg?Val?Lys

195 200 205

Ala?Ser?Ser?Ile?Asn?Tyr?Asp?Val?Thr?Glu?Ile?Gln?Pro?Gly?Asp?Glu

210 215 220

Val?Pro?Asn?His?Phe?Ser?Tyr?Thr?Ser?Arg?Asp?Glu?Asp?Tyr?Val?Lys

225 230 235 240

Asp?Gln?Val?Pro?Cys?Trp?Leu?Thr?Tyr?Thr?Asn?Gly?Thr?Ser?His?Glu

245 250 255

IleIle?Gln?Asn?Asn?Leu?His?Arg?Ala?Pro?Met?Phe?Thr?Gly?Val?Val

260 265 270

Lys?Gly?Val?Gly?Pro?Arg?Tyr?Cys?Pro?Ser?Ile?Glu?Asp?Lys?Ile?Val

275 280 285

Arg?Phe?Ala?Asp?Lys?Glu?Arg?His?Gln?Leu?Phe?Leu?Glu?Pro?Glu?Gly

290 295 300

Arg?Asn?Thr?Glu?Glu?Val?Tyr?Val?Gln?Gly?Leu?Ser?Thr?Ser?Leu?Pro

305 310 315 320

Glu?Asp?Val?Gln?Arg?Asp?Leu?Val?His?SerIle?Lys?Gly?Leu?Glu?Asn

325 330 335

Ala?Glu?Met?Met?Arg?Thr?Gly?Tyr?Ala?Ile?Glu?Tyr?Asp?Met?Val?Leu

340 345 350

Pro?His?Gln?Leu?Arg?Ala?Thr?Leu?Glu?Thr?Lys?Lys?Ile?Ser?Gly?Leu

355 360 365

Phe?Thr?Ala?Gly?Gln?Thr?Asn?Gly?Thr?Ser?Gly?Tyr?Glu?Glu?Ala?Ala

370 375 380

Gly?Gln?Gly?Ile?Ile?Ala?Gly?Ile?Asn?Ala?Ala?Leu?Lys?Ile?Gln?Gly

385 390 395 400

Lys?Pro?Glu?Leu?Ile?Leu?Lys?Arg?Ser?Asp?Gly?Tyr?Ile?Gly?Val?Met

405 410 415

Ile?Asp?Asp?Leu?Val?Thr?Lys?Gly?Thr?Ile?Glu?Pro?Tyr?Arg?Leu?Leu

420 425 430

Thr?Ser?Arg?Ala?alu?Tyr?Arg?Leu?Ile?Leu?Arg?His?Asp?Asn?Ala?Asp

435 440 445

Met?Arg?Leu?Thr?Glu?Met?Gly?Arg?Glu?Ile?Gly?Leu?Val?Asp?Asp?Glu

450 455 460

Arg?Trp?Ala?Arg?Phe?Glu?Ile?Lys?Lys?Asn?Gln?Phe?Asp?Asn?Glu?Met

465 470 475 480

Lys?Arg?Leu?Asp?Ser?Ile?Lys?Leu?Lys?Pro?Val?Lys?Glu?Thr?Asn?Ala

485 490 495

Lys?Val?Glu?Glu?Met?Gly?Phe?Lys?Pro?Leu?Thr?Asp?Ala?Val?Thr?Ala

500 505 510

Lys?Glu?Phe?Leu?Arg?Arg?Pro?Glu?Val?Ser?Tyr?Gln?Asp?Val?Val?Ala

515 520 525

Phe?Ile?Gly?Pro?Ala?Ala?Glu?Asp?Leu?Asp?Asp?Lys?Ile?Ile?Glu?Leu

530 535 540

Ile?Glu?Thr?Glu?Ile?Lys?Tyr?Glu?Gly?Tyr?Ile?Ser?Lys?Ala?Met?Asp

545 550 555 560

Gln?Val?Ala?Lys?Met?Lys?Arg?Met?Glu?Glu?Lys?Arg?Ile?Pro?Ala?Asn

565 570 575

Ile?Asp?Trp?Asp?Asp?Ile?Asp?Ser?Ile?Ala?Thr?Glu?Ala?Arg?Gln?Lys

580 585 590

Phe?Lys?Leu?Ile?Asn?Pro?Glu?Thr?Ile?Gly?Gln?Ala?Ser?Arg?Ile?Ser

595 600 605

Gly?Val?Asn?Pro?Ala?Asp?Ile?Ser?Ile?Leu?Met?Val?Tyr?Leu?Glu?Gly

610 615 620

Lys?Asn?Arg?Ser?Ile?Ser?Lys?Thr?Leu?Gln?Lys?Ser?Lys

625 630 635

<210>54

<211>185

<212>PRT

＜213〉streptococcus pneumoniae

<400>54

Met?Thr?Lys?Gln?Val?Leu?Leu?Val?Asp?Asp?Glu?Glu?His?Ile?Leu?Lys

1 5 10 15

Leu?Leu?Asp?Tyr?His?Leu?Ser?Lys?Glu?Gly?Phe?Ser?Thr?Gln?Leu?Val

20 25 30

Thr?Asn?Gly?Arg?Lys?Ala?Leu?Ala?Leu?Ala?Glu?Thr?Glu?Pro?Phe?Asp

35 40 45

Phe?Ile?Leu?Leu?Asp?Ile?Met?Leu?Pro?Gln?Leu?Asp?Gly?Met?Glu?Val

50 55 60

Cys?Lys?Arg?Leu?Arg?Ala?Lys?Gly?Val?Lys?Thr?Pro?Ile?Met?Met?Val

65 70 75 80

Ser?Ala?Lys?Ser?Asp?Glu?Phe?Asp?Lys?Val?Leu?Ala?Leu?Glu?Leu?Gly

85 90 95

Ala?Asp?Asp?Tyr?Leu?Thr?Lys?Pro?Phe?Ser?Pro?Arg?Glu?Leu?Leu?Ala

100 105 110

Arg?Val?Lys?Ala?Val?Leu?Arg?Arg?Thr?Lys?Gly?Glu?Gln?Glu?Gly?Asp

115 120 125

Asp?Ser?Asp?Asn?Ile?Ala?Asp?Asp?Ser?Trp?Leu?Phe?Gly?Thr?Leu?Lys

130 135 140

Val?Tyr?Pro?Glu?Arg?His?Glu?Val?Tyr?Lys?Ala?Asn?Lys?Leu?Leu?Ser

145 150 155 160

Leu?Thr?Pro?Lys?Glu?Phe?Glu?Ser?Asp?Lys?Asn?Pro?Phe?Phe?Glu?Val

165 170 175

Phe?Lys?Val?Ser?Lys?Val?Thr?Ala?Gln

180 185

<210>55

<211>478

<212>PRT

＜213〉streptococcus pneumoniae

<400>55

Met?Thr?Thr?Phe?Lys?Asp?Gly?Phe?Leu?Trp?Gly?Gly?Ala?Val?Ala?Ala

1 5 10 15

His?Gln?Leu?Glu?Gly?Gly?Trp?Gln?Glu?Gly?Gly?Lys?Gly?Ile?Ser?Val

20 25 30

Ala?Asp?Val?Met?Thr?Ala?Gly?Arg?His?Gly?Val?Ala?Arg?Glu?Ile?Thr

35 40 45

Leu?Gly?Val?Leu?Glu?Gly?Lys?Tyr?Tyr?Pro?Asn?His?Glu?Ala?Ile?Asp

50 55 60

Phe?Tyr?His?Arg?Tyr?Lys?Glu?Asp?Ile?Ala?Leu?Phe?Ala?Glu?Met?Gly

65 70 75 80

Phe?Lys?Cys?Phe?Arg?Thr?Ser?Ile?Ala?Trp?Thr?Arg?Ile?Phe?Pro?Lys

85 90 95

Gly?Asp?Glu?Leu?Glu?Pro?Asn?Glu?Glu?Gly?Leu?Gln?Phe?Tyr?Asp?Asn

100 105 110

Leu?Phe?Asp?Glu?Cys?Leu?Lys?Asn?Gly?Ile?Glu?Pro?Val?Ile?Thr?Leu

115 120 125

Ser?His?Phe?Glu?Met?Pro?Tyr?His?Leu?Val?Thr?Glu?Tyr?Gly?Gly?Trp

130 135 140

Lys?Asn?Arg?Lys?Leu?Ile?Asp?Phe?Phe?Ala?Arg?Phe?Ala?Glu?Val?Val

145 150 155 160

Phe?Lys?Arg?Tyr?Lys?Asp?Lys?Val?Lys?Tyr?Trp?Met?Thr?Phe?Asn?Glu

165 170 175

Ile?Asn?Asn?Gln?Ala?Asn?Tyr?Gln?Glu?Asp?Phe?Ala?Pro?Phe?Thr?Asn

180 185 190

Ser?Gly?Ile?Val?Tyr?Glu?Glu?Gly?Asp?Asn?Arg?Glu?Ala?Ile?Met?Tyr

195 200 205

Gln?Ala?Ala?His?Tyr?Glu?Leu?Val?Ala?Ser?Ala?Arg?Ala?Val?Lys?Ile

210 215 220

Gly?His?Glu?Ile?Asn?Pro?Asp?Phe?Gln?Ile?Gly?Cys?Met?Ile?Ala?Met

225 230 235 240

Cys?Pro?Ile?Tyr?Pro?Val?Thr?Cys?Asn?Pro?Lys?Asp?Ile?Leu?Met?Ala

245 250 255

Met?Lys?Ala?Met?Gln?Lys?Arg?Tyr?Tyr?Phe?Ala?Asp?Val?His?Val?Leu

260 265 270

Gly?Lys?Tyr?Pro?Glu?His?Ile?Phe?Lys?Tyr?Trp?Glu?Arg?Lys?Gly?Ile

275 280 285

Ser?Val?Asp?Phe?Thr?Ala?Gln?Asp?Lys?Glu?Asp?Leu?Leu?Gly?Gly?Thr

290 295 300

Val?Asp?Tyr?Ile?Gly?Phe?Ser?Tyr?Tyr?Met?Ser?Phe?Ala?Ile?Asp?Ser

305 310 315 320

His?Arg?Glu?Asn?Asn?Pro?Tyr?Phe?Asp?Tyr?Leu?Glu?Thr?Glu?Asp?Leu

325 330 335

Val?Lys?Asn?Asn?Tyr?Val?Lys?Ala?Ser?Glu?Trp?Glu?Trp?Gln?Ile?Asp

340 345 350

Pro?Glu?Gly?Leu?Arg?Tyr?Ala?Leu?Asn?Trp?Phe?Thr?Asp?His?Tyr?His

355 360 365

Leu?Pro?Leu?Phe?Ile?Val?Glu?Asn?Gly?Phe?Gly?Ala?Ile?Asp?Gln?Val

370 375 380

Ala?Ala?Asp?Gly?Met?Val?His?Asp?Asp?Tyr?Arg?Ile?Glu?Tyr?Leu?Gly

385 390 395 400

Ala?His?Ile?Arg?Glu?Met?Lys?Lys?Ala?Val?Val?Glu?Asp?Gly?Val?Asp

405 410 415

Leu?Met?Gly?Tyr?Thr?Pro?Trp?Gly?Cys?Ile?Asp?Leu?Val?Ser?Ala?Gly

420 425 430

Thr?Gly?Glu?Met?Arg?Lys?Arg?Tyr?Gly?Phe?Ile?Tyr?Val?Asp?Lys?Asp

435 440 445

Asp?Asn?Gly?Lys?Gly?Ser?Tyr?Asn?Arg?Ser?Pro?Lys?Lys?Ser?Phe?Gly

450 455 460

Trp?Tyr?Lys?Glu?Val?Ile?Ser?Ser?Asn?Gly?Glu?Ser?Val?Glu

465 470 475

<210>56

<211>448

<212>PRT

＜213〉streptococcus pneumoniae

<400>56

Met?Asp?Gln?Gln?Asn?Gly?Leu?Phe?Gly?Phe?Leu?Glu?Asn?His?Val?Met

1 5 10 15

Gly?Pro?Met?Gly?Lys?Leu?Ala?Gln?Phe?Lys?Val?Val?Arg?Ala?Ile?Thr

20 25 30

Ala?Ala?Gly?Met?Ala?Ala?Val?Pro?Phe?Thr?Ile?Val?Gly?Ser?Met?Phe

35 40 45

Leu?Val?Phe?Ser?Ile?Leu?Pro?Gln?Ala?Phe?Ser?Phe?Trp?Pro?Ile?Val

50 55 60

Ala?Asp?Ile?Phe?Ser?Ala?Ser?Phe?Asp?Lys?Phe?Thr?Ser?Leu?Tyr?Met

65 70 75 80

Val?Ala?Asn?Tyr?Ala?Thr?Met?Gly?Ser?Leu?Ser?Leu?Tyr?Phe?Val?Leu

85 90 95

Ser?Leu?Ala?Tyr?Glu?Leu?Thr?Lys?Ile?Tyr?Ala?Glu?Glu?Glu?Glu?Leu

100 105 110

Asn?Met?Asn?Pro?Leu?Asn?Gly?Ala?Leu?Leu?Ala?Leu?Met?Ala?Phe?Val

115 120 125

Met?Thr?Val?Pro?Gln?Ile?Ile?Phe?Asp?Gly?Gly?Met?Met?Lys?Thr?Val

130 135 140

Thr?Ser?Leu?Lys?Glu?Gly?Ala?Val?Ile?Ala?Asp?Gly?Trp?Ala?Met?Gly

145 150 155 160

Asn?Val?Val?Ala?Arg?Phe?Gly?Thr?Thr?Gly?Ile?Phe?Thr?Ala?Ile?Ile

165 170 175

Met?Ala?Ile?Val?Thr?Val?Leu?Ile?Tyr?Arg?Met?Cys?Val?Lys?His?Asn

180 185 190

Trp?Val?Ile?Lys?Met?Pro?Glu?Ala?Val?Pro?Glu?Gly?Val?Ser?Arg?Gly

195 200 205

Phe?Thr?Ala?Leu?Val?Pro?Gly?Phe?Val?Val?Ala?Phe?Val?Val?Ile?Phe

210 215 220

Ile?Asn?Gly?Leu?Leu?Val?Ala?Met?Gly?Thr?Asp?Ile?Phe?Lys?Val?Ile

225 230 235 240

Ala?Ile?Pro?Phe?Gly?Phe?Val?Ser?Asn?Leu?Thr?Asn?Ser?Trp?Ile?Gly

245 250 255

Leu?Met?Ile?Ile?Tyr?Leu?Leu?Thr?Gln?Leu?Leu?Trp?Ile?Val?Gly?Ile

260 265 270

His?Gly?Ala?Asn?Ile?Val?Phe?Ala?Phe?Val?Ser?Pro?Ile?Ala?Leu?Ala

275 280 285

Asn?Met?Ala?Glu?Asn?Ala?Ala?Gly?Gly?His?Phe?Ala?Val?Ala?Gly?Glu

290 295 300

Phe?Ser?Asn?Met?Phe?Val?Ile?Ala?Gly?Gly?Ser?Gly?Ala?Thr?Leu?Gly

305 310 315 320

Leu?Cys?Leu?Tyr?Ile?Ala?Phe?Ala?Ser?Lys?Ser?Glu?Gln?Leu?Lys?Ala

325 330 335

Ile?Gly?Arg?Ala?Ser?Val?Val?Pro?Ala?Leu?Phe?Asn?Ile?Asn?Glu?Pro

340 345 350

Leu?Ile?Phe?Gly?Leu?Pro?Ile?Ile?Tyr?Asn?Pro?Ala?Leu?Ala?Ile?Pro

355 360 365

Phe?Ile?Leu?Ala?Pro?Met?Val?Thr?Ala?Thr?Ile?Tyr?Tyr?Val?Ala?Asn

370 375 380

Ser?Leu?Asn?Phe?Ile?Lys?Pro?Ile?Ile?Ala?Gln?Val?Pro?Trp?Pro?Thr

385 390 395 400

Pro?Val?Gly?Ile?Gly?Ala?Phe?Leu?Gly?Thr?Ala?Asp?Leu?Arg?Ala?Val

405 410 415

Leu?Val?Ala?Leu?Val?Cys?Ala?Phe?Ala?Ala?Phe?Leu?Val?Tyr?Leu?Pro

420 425 430

Phe?Ile?Arg?Val?Tyr?Asp?Gln?Lys?Leu?Val?Lys?Glu?Glu?Gln?Gly?Ile

435 440 445

<210>57

<211>657

<212>PRT

＜213〉streptococcus pneumoniae

<400>57

Met?Lys?Lys?Phe?Tyr?Val?Ser?Pro?Ile?Phe?Pro?Ile?Leu?Val?Gly?Leu

1 5 10 15

Ile?Ala?Phe?Gly?Val?Leu?Ser?Thr?Phe?Ile?Ile?Phe?Val?Asn?Asn?Asn

20 25 30

Leu?Leu?Thr?Val?Leu?Ile?Leu?Phe?Leu?Phe?Val?Gly?Gly?Tyr?Val?Phe

35 40 45

Leu?Phe?Lys?Lys?Leu?Arg?Val?His?Tyr?Thr?Arg?Ser?Asp?Val?Glu?Gln

50 55 60

Ile?Gln?Tyr?Val?Asn?His?Gln?Ala?Glu?Glu?Ser?Leu?Thr?Ala?Leu?Leu

65 70 75 80

Glu?Gln?Met?Pro?Val?Gly?Val?Met?Lys?Leu?Asn?Leu?Ser?Ser?Gly?Glu

85 90 95

Val?Glu?Trp?Phe?Asn?Pro?Tyr?Ala?Glu?Leu?Ile?Leu?Thr?Lys?Glu?Asp

100 105 110

Gly?Asp?Phe?Asp?Leu?Glu?Ala?Val?Gln?Thr?Ile?Ile?Lys?Ala?Ser?Val

115 120 125

Gly?Asn?Pro?Ser?Thr?Tyr?Ala?Lys?Leu?Gly?Glu?Lys?Arg?Tyr?Ala?Val

130 135 140

His?Met?Asp?Ala?Ser?Ser?Gly?Val?Leu?Tyr?Phe?Val?Asp?Val?Ser?Arg

145 150 155 160

Glu?Gln?Ala?Ile?Thr?Asp?Glu?Leu?Val?Thr?Ser?Arg?Pro?Val?Ile?Gly

165 170 175

Ile?Val?Ser?Val?Asp?Asn?Tyr?Asp?Asp?Leu?Glu?Asp?Glu?Thr?Ser?Glu

180 185 190

Ser?Asp?Ile?Ser?Gln?Ile?Asn?Ser?Phe?Val?Ala?Asn?Phe?Ile?Ser?Glu

195 200 205

Phe?Ser?Glu?Lys?His?Met?Met?Phe?Ser?Arg?Arg?Val?Ser?Met?Asp?Arg

210 215 220

Phe?Tyr?Leu?Phe?Thr?Asp?Tyr?Thr?Val?Leu?Glu?Gly?Leu?Met?Asn?Asp

225 230 235 240

Lys?Phe?Ser?Val?Ile?Asp?Ala?Phe?Arg?Glu?Glu?Ser?Lys?Gln?Arg?Gln

245 250 255

Leu?Pro?Leu?Thr?Leu?Ser?Met?Gly?Phe?Ser?Tyr?Gly?Asp?Gly?Asn?His

260 265 270

Asp?Glu?Ile?Gly?Lys?Val?Ala?Leu?Leu?Asn?Leu?Asn?Leu?Ala?Glu?Val

275 280 285

Arg?Gly?Gly?Asp?Gln?Val?Val?Val?Lys?Glu?Asn?Asp?Glu?Thr?Lys?Asn

290 295 300

Pro?Val?Tyr?Phe?Gly?Gly?Gly?Ser?Ala?Ala?Ser?Ile?Lys?Arg?Thr?Arg

305 310 315 320

Thr?Arg?Thr?Arg?Ala?Met?Met?Thr?Ala?Ile?Ser?Asp?Lys?Ile?Arg?Ser

325 330 335

Val?Asp?Gln?Val?Phe?Val?Val?Gly?His?Lys?Asn?Leu?Asp?Met?Asp?Ala

340 345 350

Leu?Gly?Ser?Ala?Val?Gly?Met?Gln?Leu?Phe?Ala?Ser?Asn?Val?Ile?Glu

355 360 365

Asn?Ser?Tyr?Ala?Leu?Tyr?Asp?Glu?Glu?Gln?Met?Ser?Pro?Asp?Ile?Glu

370 375 380

Arg?Ala?Val?Ser?Phe?Ile?Glu?Lys?Glu?Gly?Val?Thr?Lys?Leu?Leu?Ser

385 390 395 400

Val?Lys?Asp?Ala?Met?Gly?Met?Val?Thr?Asn?Arg?Ser?Leu?Leu?Ile?Leu

405 410 415

Val?Asp?His?Ser?Lys?Thr?Ala?Leu?Thr?Leu?Ser?Lys?Glu?Phe?Tyr?Asp

420 425 430

Leu?Phe?Thr?Gln?Thr?Ile?Val?Ile?Asp?His?His?Arg?Arg?Asp?Gln?Asp

435 440 445

Phe?Pro?Asp?Asn?Ala?Val?Ile?Thr?Tyr?Ile?Glu?Ser?Gly?Ala?Ser?Ser

450 455 460

Ala?Ser?Glu?Leu?Val?Thr?Glu?Leu?Ile?Gln?Phe?Gln?Asn?Ser?Lys?Lys

465 470 475 480

Asn?Arg?Leu?Ser?Arg?Met?Gln?Ala?Ser?Val?Leu?Met?Ala?Gly?Met?Met

485 490 495

Leu?Asp?Thr?Lys?Asn?Phe?Thr?Ser?Arg?Val?Thr?Ser?Arg?Thr?Phe?Asp

500 505 510

Val?Ala?Ser?Tyr?Leu?Arg?Thr?Arg?Gly?Ser?Asp?Ser?Ile?Ala?Ile?Gln

515 520 525

Glu?Ile?Ala?Ala?Thr?Asp?Phe?Glu?Glu?Tyr?Arg?Glu?Val?Asn?Glu?Leu

530 535 540

Ile?Leu?Gln?Gly?Arg?Lys?Leu?Gly?Ser?Asp?Val?Leu?Ile?Ala?Glu?Ala

545 550 555 560

Lys?Asp?Met?Lys?Cys?Tyr?Asp?Thr?Val?Val?Ile?Ser?Lys?Ala?Ala?Asp

565 570 575

Ala?Met?Leu?Ala?Met?Ser?Gly?Ile?Glu?Ala?Ser?Phe?Val?Leu?Ala?Lys

580 585 590

Asn?Thr?Gln?Gly?Phe?Ile?Ser?Ile?Ser?Ala?Arg?Ser?Arg?Ser?Lys?Leu

595 600 605

Asn?Val?Gln?Arg?Ile?Met?Glu?Glu?Leu?Gly?Gly?Gly?Gly?His?Phe?Asn

610 615 620

Leu?Ala?Ala?Ala?Gln?Ile?Lys?Asp?Val?Thr?Leu?Ser?Glu?Ala?Gly?Glu

625 630 635 640

Lys?Leu?Thr?Glu?Ile?Val?Leu?Asn?Glu?Met?Lys?Glu?Lys?Glu?Lys?Glu

645 650 655

Glu

<210>58

<211>235

<212>PRT

＜213〉streptococcus pneumoniae

<400>58

Met?Lys?Glu?Lys?Asn?Met?Trp?Lys?Glu?Leu?Leu?Asn?Arg?Ala?Gly?Trp

1 5 10 15

Ile?Leu?Val?Phe?Leu?Leu?Ala?Val?Leu?Leu?Tyr?Gln?Val?Pro?Leu?Val

20 25 30

Val?Thr?Ser?Ile?Leu?Thr?Leu?Lys?Glu?Val?Ala?Leu?Leu?Gln?Ser?Gly

35 40 45

Leu?Ile?Val?Ala?Gly?Leu?Ser?Ile?Val?Val?Leu?Ala?Leu?Phe?Ile?Met

50 55 60

Gly?Ala?Arg?Lys?Thr?Lys?Leu?Ala?Ser?Phe?Asn?Phe?Ser?Phe?Phe?Arg

65 70 75 80

Ala?Lys?Asp?Leu?Ala?Arg?Leu?Gly?Leu?Ser?Tyr?Leu?Val?Ile?Val?Gly

85 90 95

Ser?Asn?Ile?Leu?Gly?Ser?Ile?Leu?Leu?Gln?Leu?Ser?Asn?Glu?Thr?Thr

100 105 110

Thr?Ala?Asn?Gln?Ser?Gln?Ile?Asn?Asp?Met?Val?Gln?Asn?Ser?Ser?Leu

115 120 125

Ile?Ser?Ser?Phe?Phe?Leu?Leu?Ala?Leu?Leu?Ala?Pro?Ile?Cys?Glu?Glu

130 135 140

Ile?Leu?Cys?Arg?Gly?Ile?Val?Pro?Lys?Lys?Ile?Phe?Arg?Gly?Lys?Glu

145 150 155 160

Asn?Leu?Gly?Phe?Val?Val?Gly?Thr?Ile?Val?Phe?Ala?Leu?Leu?His?Gln

165 170 175

Pro?Ser?Asn?Leu?Pro?Ser?Leu?Leu?Ile?Tyr?Gly?Gly?Met?Ser?Thr?Val

180 185 190

Leu?Ser?Trp?Thr?Ala?Tyr?Lys?Thr?Gln?Arg?Leu?Glu?Met?Ser?Ile?Leu

195 200 205

Leu?His?Met?Ile?Val?Asn?Gly?Ile?Ala?Phe?Cys?Leu?Leu?Ala?Leu?Val

210 215 220

Val?Ile?Met?Ser?Arg?Thr?Leu?Gly?Ile?Ser?Val

225 230 235

<210>59

<211>235

<212>PRT

＜213〉streptococcus pneumoniae

<400>59

Met?Lys?Glu?Lys?Asn?Met?Trp?Lys?Glu?Leu?Leu?Asn?Arg?Ala?Gly?Trp

1 5 10 15

Ile?Leu?Val?Phe?Leu?Leu?Ala?Val?Leu?Leu?Tyr?Gln?Val?Pro?Leu?Val

20 25 30

Val?Thr?Ser?Ile?Leu?Thr?Leu?Lys?Glu?Val?Ala?Leu?Leu?Gln?Ser?Gly

35 40 45

Leu?Ile?Mal?Ala?Gly?Leu?Ser?Ile?Val?Val?Leu?Ala?Leu?Phe?Ile?Met

50 55 60

Gly?Ala?Arg?Lys?Thr?Lys?Leu?Ala?Ser?Phe?Asn?Phe?Ser?Phe?Phe?Arg

65 70 75 80

Ala?Lys?Asp?Leu?Ala?Arg?Leu?Gly?Leu?Ser?Tyr?Leu?Val?Ile?Val?Gly

85 90 95

Ser?Asn?Ile?Leu?Gly?Ser?Ile?Leu?Leu?Gln?Leu?Ser?Asn?Glu?Thr?Thr

100 105 110

Thr?Ala?Asn?Gln?Ser?Gln?Ile?Asn?Asp?Met?Val?Gln?Asn?Ser?Ser?Leu

115 120 125

Ile?Ser?Ser?Phe?Phe?Leu?Leu?Ala?Leu?Leu?Ala?Pro?Ile?Cys?Glu?Glu

130 135 140

Ile?Leu?Cys?Arg?Gly?Ile?Val?Pro?Lys?Lys?Ile?Phe?Arg?Gly?Lys?Glu

145 150 155 160

Asn?Leu?Gly?Phe?Val?Val?Gly?Thr?Ile?Val?Phe?Ala?Leu?Leu?His?Gln

165 170 175

Pro?Ser?Asn?Leu?Pro?Ser?Leu?Leu?Ile?Tyr?Gly?Gly?Met?Ser?Thr?Val

180 185 190

Leu?Ser?Trp?Thr?Ala?Tyr?Lys?Thr?Gln?Arg?Leu?Glu?Met?Ser?Ile?Leu

195 200 205

Leu?His?Met?Ile?Val?Asn?Gly?Ile?Ala?Phe?Cys?Leu?Leu?Ala?Leu?Val

210 215 220

Val?Ile?Met?Ser?Arg?Thr?Leu?Gly?Ile?Ser?Val

225 230 235

<210>60

<211>533

<212>PRT

＜213〉streptococcus pneumoniae

<400>60

Met?Asp?Thr?Gln?Lys?Ile?Glu?Ala?Ala?Val?Lys?Met?Ile?Ile?Glu?Ala

1 5 10 15

Val?Gly?Glu?Asp?Ala?Asn?Arg?Glu?Gly?Leu?Gln?Glu?Thr?Pro?Ala?Arg

20 25 30

Val?Ala?Arg?Met?Tyr?Gln?Glu?Ile?Phe?Ser?Gly?Leu?Gly?Gln?Thr?Ala

35 40 45

Glu?Glu?His?Leu?Ser?Lys?Ser?Phe?Glu?Ile?Ile?Asp?Asp?Asn?Met?Val

50 55 60

Val?Glu?Lys?Asp?Ile?Phe?Phe?His?Thr?Met?Cys?Glu?His?His?Phe?Leu

65 70 75 80

Pro?Phe?Tyr?Gly?Arg?Ala?His?Ile?Ala?Tyr?Ile?Pro?Asp?Gly?Arg?Val

85 90 95

Ala?Gly?Leu?Ser?Lys?Leu?Ala?Arg?Thr?Val?Glu?Val?Tyr?Ser?Lys?Lys

100 105 110

Pro?Gln?Ile?Gln?Glu?Arg?Leu?Asn?Ile?Glu?Val?Ala?Asp?Ala?Leu?Met

115 120 125

Asp?Tyr?Leu?Gly?Ala?Lys?Gly?Ala?Phe?Val?Val?Ile?Glu?Ala?Glu?His

130 135 140

Met?Cys?Met?Ser?Met?Arg?Gly?Val?Arg?Lys?Pro?Gly?Thr?Ala?Thr?Leu

145 150 155 160

Thr?Thr?Val?Ala?Arg?Gly?Leu?Phe?Glu?Thr?Asp?Lys?Asp?Leu?Arg?Asp

165 170 175

Gln?Ala?Tyr?Arg?Leu?Met?Gly?Leu?Met?Lys?Asp?Leu?Phe?Leu?Lys?Arg

180 185 190

Lys?Gln?Ala?Phe?Arg?Lys?Glu?Cys?Leu?Gly?Tyr?Leu?Arg?Tyr?Val?Leu

195 200 205

Asn?Asp?His?Phe?Val?Leu?Phe?Leu?Leu?Val?Leu?Leu?Gly?Phe?Leu?Ala

210 215 220

Tyr?Gln?Tyr?Ser?Gln?Leu?Leu?Gln?His?Phe?Pro?Glu?Asn?His?Trp?Pro

225 230 235 240

Ile?Leu?Leu?Phe?Val?Gly?Ile?Thr?Ser?Val?Leu?Leu?Leu?Leu?Trp?Gly

245 250 255

Gly?Thr?Ala?Thr?Tyr?Met?Glu?Ala?Pro?Asp?Lys?Leu?Phe?Leu?Leu?Val

260 265 270

Gly?Glu?Glu?Glu?Ile?Lys?Leu?His?Leu?Lys?Arg?Gln?Thr?Gly?Ile?Ser

275 280 285

Leu?Val?Phe?Trp?Leu?Phe?Val?Gln?Thr?Leu?Phe?Leu?Leu?Leu?Phe?Ala

290 295 300

Pro?Leu?Phe?Leu?Ala?Met?Gly?Tyr?Gly?Leu?Pro?Val?Phe?Leu?Leu?Tyr

305 310 315 320

Val?Leu?Leu?Leu?Gly?Val?Gly?Lys?Tyr?Phe?His?Phe?Cys?Gln?Lys?Ala

325 330 335

Ser?Lys?Phe?Phe?Thr?Glu?Thr?Gly?Leu?Asp?Trp?Asp?Tyr?Val?Ile?Ser

340 345 350

Gln?Glu?Ser?Lys?Arg?Lys?Gln?Val?Leu?Leu?Arg?Phe?Phe?Ala?Leu?Phe

355 360 365

Thr?Gln?Val?Lys?Gly?Ile?Ser?Asn?Ser?Val?Lys?Arg?Arg?Ala?Tyr?Leu

370 375 380

Asp?Phe?Ile?Leu?Lys?Ala?Val?Gln?Lys?Val?Pro?Gly?Lys?Ile?Trp?Gln

385 390 395 400

Asn?Leu?Tyr?Leu?Arg?Ser?Tyr?Leu?Arg?Asn?Gly?Asp?Leu?Phe?Ala?Leu

405 410 415

Ser?Leu?Arg?Leu?Leu?Leu?Leu?Ser?Leu?Leu?Ala?Gln?Val?Phe?Ile?Glu

420 425 430

Gln?Ala?Trp?Ile?Ala?Thr?Ala?Val?Val?Val?Leu?Phe?Asn?Tyr?Leu?Leu

435 440 445

Leu?Phe?Gln?Leu?Leu?Ala?Leu?Tyr?His?Ala?Phe?Asp?Tyr?Gln?Tyr?Leu

450 455 460

Thr?Gln?Leu?Phe?Pro?Leu?Asp?Lys?Gly?Gln?Lys?Glu?Lys?Gly?Leu?Gln

465 470 475 480

Glu?Val?Val?Arg?Gly?Leu?Thr?Ser?Phe?Val?Leu?Leu?Val?Glu?Leu?Val

485 490 495

Val?Gly?Leu?Ile?Thr?Phe?Gln?Glu?Lys?Leu?Ala?Leu?Leu?Ala?Leu?Leu

500 505 510

Gly?Ala?Gly?Leu?Val?Leu?Leu?Val?Leu?Tyr?Leu?Pro?Tyr?Gln?Val?Lys

515 520 525

Arg?Gln?Met?Gln?Asp

530

<210>61

<211>398

<212>PRT

＜213〉streptococcus pneumoniae

<400>61

Met?Arg?Lys?Ser?Ile?Val?Leu?Ala?Ala?Asp?Asn?Ala?Tyr?Leu?Ile?Pro

1 5 10 15

Leu?Glu?Thr?Thr?Ile?Lys?Ser?Val?Leu?Tyr?His?Asn?Arg?Asp?Val?Asp

20 25 30

Phe?Tyr?Ile?Leu?Asn?Ser?Asp?Ile?Ala?Pro?Glu?Trp?Phe?Lys?Leu?Leu

35 40 45

Gly?Arg?Lys?Met?Glu?Val?Val?Asn?Ser?Thr?Ile?Arg?Ser?Val?His?Ile

50 55 60

Asp?Lys?Glu?Leu?Phe?Glu?Ser?Tyr?Lys?Thr?Gly?Pro?His?Ile?Asn?Tyr

65 70 75 80

Ala?Ser?Tyr?Phe?Arg?Phe?Phe?Ala?Thr?Glu?Val?Val?Glu?Ser?Asp?Arg

85 90 95

Val?Leu?Tyr?Leu?Asp?Ser?Asp?Ile?Ile?Val?Thr?Gly?Glu?Leu?Ala?Thr

100 105 110

Leu?Phe?Glu?Ile?Asp?Leu?Lys?Gly?Tyr?Ser?Ile?Gly?Ala?Val?Asp?Asp

115 120 125

Val?Tyr?Ala?Tyr?Glu?Gly?Arg?Lys?Ser?Gly?Phe?Asn?Thr?Gly?Met?Leu

130 135 140

Leu?Met?Asp?Val?Ala?Lys?Trp?Lys?Glu?His?Ser?Ile?Val?Asn?Ser?Leu

145 150 155 160

Leu?Glu?Leu?Ala?Ala?Glu?Gln?Asn?Gln?Val?Val?His?Leu?Gly?Asp?Gln

165 170 175

Ser?Ile?Leu?Asn?Ile?Tyr?Phe?Glu?Asp?Asn?Trp?Leu?Ala?Leu?Asp?Lys

180 185 190

Thr?Tyr?Asn?Tyr?Met?Val?Gly?Ile?Asp?Ile?Tyr?His?Leu?Ala?Gln?Glu

195 200 205

Cys?Glu?Arg?Leu?Asp?Asp?Asn?Pro?Pro?Thr?Ile?Val?His?Tyr?Ala?Ser

210 215 220

His?Asp?Lys?Pro?Trp?Asn?Thr?Tyr?Ser?Ile?Ser?Arg?Leu?Arg?Glu?Leu

225 230 235 240

Trp?Trp?Val?Tyr?Arg?Asp?Leu?Asp?Trp?Ser?Glu?Ile?Ala?Phe?Gln?Arg

245 250 255

Ser?Asp?Leu?Asn?Tyr?Phe?Glu?Arg?Ser?Asn?Gln?Ser?Lys?Lys?Gln?Val

260 265 270

Met?Leu?Val?Thr?Trp?Ser?Ala?Asp?Ile?Lys?His?Leu?Glu?Tyr?Leu?Val

275 280 285

Gln?Arg?Leu?Pro?Asp?Trp?His?Phe?His?Leu?Ala?Ala?Pro?Cys?Asp?Cys

290 295 300

Ser?Glu?Glu?Leu?Thr?Ser?Leu?Ser?Gln?Tyr?Thr?Asn?Val?Thr?Val?Tyr

305 310 315 320

Gln?Asn?Val?Leu?His?Ser?Arg?Ile?Asp?Trp?Leu?Leu?Asp?Asp?Ser?Ile

325 330 335

Val?Tyr?Leu?Asp?Ile?Asn?Thr?Gly?Gly?Glu?Val?Phe?Asn?Val?Val?Thr

340 345 350

Arg?Ala?Gln?Glu?Ser?Gly?Lys?Lys?Ile?Phe?Ala?Phe?Asp?Ile?Thr?Arg

355 360 365

Lys?Ser?Met?Asp?Asp?Gly?Leu?Tyr?Asp?Gly?Ile?Phe?Ser?Val?Glu?Arg

370 375 380

Pro?Asp?Asp?Leu?Val?Asp?Arg?Met?Lys?Asn?Ile?Glu?Ile?Glu

385 390 395

<210>62

<211>405

<212>PRT

＜213〉streptococcus pneumoniae

<400>62

Met?Thr?Lys?Ile?Tyr?Ser?Ser?Ile?Ala?Val?Lys?Lys?Gly?Leu?Phe?Thr

1 5 10 15

Ser?Phe?Leu?Leu?Phe?Ile?Tyr?Val?Leu?Gly?Ser?Arg?Ile?Ile?Leu?Pro

20 25 30

Phe?Val?Asp?Leu?Asn?Thr?Lys?Asp?Phe?Leu?Gly?Gly?Ser?Thr?Ala?Tyr

35 40 45

Leu?Ala?Phe?Ser?Ala?Ala?Leu?Thr?Gly?Gly?Asn?Leu?Arg?Ser?Leu?Ser

50 55 60

Ile?Phe?Ser?Val?Gly?Leu?Ser?Pro?Trp?Met?Ser?Ala?Met?Ile?Leu?Trp

65 70 75 80

Gln?Met?Phe?Ser?Phe?Ser?Lys?Arg?Leu?Gly?Leu?Thr?Ser?Thr?Ser?Ile

85 90 95

Glu?Ile?Gln?Asp?Arg?Arg?Lys?Met?Tyr?Leu?Thr?Leu?Leu?Ile?Ala?Val

100 105 110

Ile?Gln?Ser?Leu?Ala?Val?Ser?Leu?Arg?Leu?Pro?Val?Gln?Ser?Ser?Tyr

115 120 125

Ser?Ala?Ile?Leu?Val?Val?Leu?Met?Asn?Thr?Ile?Leu?Leu?Ile?Ala?Gly

130 135 140

Thr?Phe?Phe?Leu?Val?Trp?Leu?Ser?Asp?Leu?Asn?Ala?Ser?Met?Gly?Ile

145 150 155 160

Gly?Gly?Ser?Ile?Val?Ile?Leu?Leu?Ser?Ser?Met?Val?Leu?Asn?Ile?Pro

165 170 175

Gln?Asp?Val?Leu?Glu?Thr?Phe?Gln?Thr?Val?His?Ile?Pro?Thr?Gly?Ile

180 185 190

Ile?Val?Leu?Leu?Ala?Leu?Leu?Thr?Leu?Val?Phe?Ser?Tyr?Leu?Leu?Ala

195 200 205

Leu?Met?Tyr?Arg?Ala?Arg?Tyr?Leu?Val?Pro?Val?Asn?Lys?Ile?Gly?Leu

210 215 220

His?Asn?Arg?Phe?Lys?Arg?Tyr?Ser?Tyr?Leu?Glu?Ile?Met?Leu?Asn?Pro

225 230 235 240

Ala?Gly?Gly?Met?Pro?Tyr?Met?Tyr?Val?Met?Ser?Phe?Leu?Ser?Val?Pro

245 250 255

Ala?Tyr?Leu?Phe?Ile?Leu?Leu?Gly?Phe?Ile?Phe?Pro?Asn?His?Ser?Gly

260 265 270

Leu?Ala?Ala?Leu?Ser?Lys?Glu?Phe?Met?Val?Gly?Lys?Pro?Leu?Trp?Val

275 280 285

Tyr?Val?Tyr?Ile?Ser?Val?Leu?Phe?Leu?Phe?Ser?Ile?Ile?Phe?Ala?Phe

290 295 300

Val?Thr?Met?Asn?Gly?Glu?Glu?Ile?Ala?Asp?Arg?Met?Lys?Lys?Ser?Gly

305 310 315 320

Glu?Tyr?Ile?Tyr?Gly?Ile?Tyr?Pro?Gly?Ala?Asp?Thr?Ser?Arg?Phe?Ile

325 330 335

Asn?Arg?Leu?Val?Leu?Arg?Phe?Ser?Val?Ile?Gly?Gly?Leu?Phe?Asn?Val

340 345 350

Ile?Met?Ala?Gly?Gly?Pro?Met?Leu?Phe?Val?Leu?Phe?Asp?Glu?Lys?Leu

355 360 365

Leu?Arg?Leu?Ala?Met?Ile?Pro?Gly?Leu?Phe?Met?Met?Phe?Gly?Gly?Met

370 375 380

Ile?Phe?Thr?Ile?Arg?Asp?Glu?Val?Lys?Ala?Leu?Arg?Leu?Asn?Glu?Thr

385 390 395 400

Tyr?Arg?Pro?Leu?Ile

405

<210>63

<211>763

<212>PRT

＜213〉streptococcus pneumoniae

<400>63

Met?Ser?Ser?Leu?Ser?Asp?Gln?Glu?Leu?Val?Ala?Lys?Thr?Val?Glu?Phe

1 5 10 15

Arg?Gln?Arg?Leu?Ser?Glu?Gly?Glu?Ser?Leu?Asp?Asp?Ile?Leu?Val?Glu

20 25 30

Ala?Phe?Ala?Val?Val?Arg?Glu?Ala?Asp?Lys?Arg?Ile?Leu?Gly?Met?Phe

35 40 45

Pro?Tyr?Asp?Val?Gln?Val?Met?Gly?Ala?Ile?Val?Met?His?Tyr?Gly?Asn

50 55 60

Val?Ala?Glu?Met?Asn?Thr?Gly?Glu?Gly?Lys?Thr?Leu?Thr?Ala?Thr?Met

65 70 75 80

Pro?Val?Tyr?Leu?Asn?Ala?Phe?Ser?Gly?Glu?Gly?Val?Met?Val?Val?Thr

85 90 95

Pro?Asn?Glu?Tyr?Leu?Ser?Lys?Arg?Asp?Ala?Glu?Glu?Met?Gly?Gln?Val

100 105 110

Tyr?Arg?Phe?Leu?Gly?Leu?Thr?Ile?Gly?Val?Pro?Phe?Thr?Glu?Asp?Pro

115 120 125

Lys?Lys?Glu?Met?Lys?Ala?Glu?Glu?Lys?Lys?Leu?Ile?Tyr?Ala?Ser?Asp

130 135 140

Ile?Ile?Tyr?Thr?Thr?Asn?Ser?Asn?Leu?Gly?Phe?Asp?Tyr?Leu?Asn?Asp

145 150 155 160

Asn?Leu?Ala?Ser?Asn?Glu?Glu?Gly?Lys?Phe?Leu?Arg?Pro?Phe?Asn?Tyr

165 170 175

Val?Ile?Ile?Asp?Glu?Ile?Asp?Asp?Ile?Leu?Leu?Asp?Ser?Ala?Gln?Thr

180 185 190

Pro?Leu?Ile?Ile?Ala?Gly?Ser?Pro?Arg?Val?Gln?Ser?Asn?Tyr?Tyr?Ala

195 200 205

Ile?Ile?Asp?Thr?Leu?Val?Thr?Thr?Leu?Val?Glu?Gly?Glu?Asp?Tyr?Ile

210 215 220

Phe?Lys?Glu?Glu?Lys?Glu?Glu?Val?Trp?Leu?Thr?Thr?Lys?Gly?Ala?Lys

225 230 235 240

Ser?Ala?Glu?Asn?Phe?Leu?Gly?Ile?Asp?Asn?Leu?Tyr?Lys?Glu?Glu?His

245 250 255

Ala?Ser?Phe?Ala?Arg?His?Leu?Val?Tyr?Ala?Ile?Arg?Ala?His?Lys?Leu

260 265 270

Phe?Thr?Lys?Asp?Lys?Asp?Tyr?Ile?Ile?Arg?Gly?Asn?Glu?Met?Val?Leu

275 280 285

Val?Asp?Lys?Gly?Thr?Gly?Arg?Leu?Met?Glu?Met?Thr?Lys?Leu?Gln?Gly

290 295 300

Gly?Leu?His?Gln?Ala?Ile?Glu?Ala?Lys?Glu?His?Val?Lys?Leu?Ser?Pro

305 310 315 320

Glu?Thr?Arg?Ala?Met?Ala?Ser?Ile?Thr?Tyr?Gln?Ser?Leu?Phe?Lys?Met

325 330 335

Phe?Asn?Lys?Ile?Ser?Gly?Met?Thr?Gly?Thr?Gly?Lys?Val?Ala?Glu?Lys

340 345 350

Glu?Phe?Ile?Glu?Thr?Tyr?Asn?Met?Ser?Val?Val?Arg?Ile?Pro?Thr?Asn

355 360 365

Arg?Pro?Arg?Gln?Arg?Ile?Asp?Tyr?Pro?Asp?Asn?Leu?Tyr?Ile?Thr?Leu

370 375 380

Pro?Glu?Lys?Val?Tyr?Ala?Ser?Leu?Glu?Tyr?Ile?Lys?Gln?Tyr?His?Ala

385 390 395 400

Lys?Gly?Asn?Pro?Leu?Leu?Val?Phe?Val?Gly?Ser?Val?Glu?Met?Ser?Gln

405 410 415

Leu?Tyr?Ser?Ser?Leu?Leu?Phe?Arg?Glu?Gly?Ile?Ala?His?Asn?Val?Leu

420 425 430

Asn?Ala?Asn?Asn?Ala?Ala?Arg?Glu?Ala?Gln?Ile?Ile?Ser?Glu?Ser?Gly

435 440 445

Gln?Met?Gly?Ala?Val?Thr?Val?Ala?Thr?Ser?Met?Ala?Gly?Arg?Gly?Thr

450 455 460

Asp?Ile?Lys?Leu?Gly?Lys?Gly?Val?Ala?Glu?Leu?Gly?Gly?Leu?Ile?Val

465 470 475 480

Ile?Gly?Thr?Glu?Arg?Met?Glu?Ser?Gln?Arg?Ile?Asp?Leu?Gln?Ile?Arg

485 490 495

Gly?Arg?Ser?Gly?Arg?Gln?Gly?Asp?Pro?Gly?Met?Ser?Lys?Phe?Phe?Val

500 505 510

Ser?Leu?Glu?Asp?Asp?Val?Ile?Lys?Lys?Phe?Gly?Pro?Ser?Trp?Val?His

515 520 525

Lys?Lys?Tyr?Lys?Asp?Tyr?Gln?Val?Gln?Asp?Met?Thr?Gln?Pro?Glu?Val

530 535 540

Leu?Lys?Gly?Arg?Lys?Tyr?Arg?Lys?Leu?Val?Glu?Lys?Ala?Gln?His?Ala

545 550 555 560

Ser?Asp?Ser?Ala?Gly?Arg?Ser?Ala?Arg?Arg?Gln?Thr?Leu?Glu?Tyr?Ala

565 570 575

Glu?Ser?Met?Asn?Ile?Gln?Arg?Asp?Ile?Val?Tyr?Lys?Glu?Arg?Asn?Arg

580 585 590

Leu?Ile?Asp?Gly?Ser?Arg?Asp?Leu?Glu?Asp?Val?Val?Val?Asp?Ile?Ile

595 600 605

Glu?Arg?Tyr?Thr?Glu?Glu?Val?Ala?Ala?Asp?His?Tyr?Ala?Ser?Arg?Glu

610 615 620

Leu?Leu?Phe?His?Phe?Ile?Val?Thr?Asn?Ile?Ser?Phe?His?Val?Lys?Glu

625 630 635 640

Val?Pro?Asp?Tyr?Ile?Asp?Val?Thr?Asp?Lys?Thr?Ala?Val?Arg?Ser?Phe

645 650 655

Met?Lys?Gln?Val?Ile?Asp?Lys?Glu?Leu?Ser?Glu?Lys?Lys?Glu?Leu?Leu

660 665 670

Asn?Gln?His?Asp?Leu?Tyr?Glu?Gln?Phe?Leu?Arg?Leu?Ser?Leu?Leu?Lys

675 680 685

Ala?Ile?Asp?Asp?Asn?Trp?Val?Glu?Gln?Val?Asp?Tyr?Leu?Gln?Gln?Leu

690 695 700

Ser?Met?Ala?Ile?Gly?Gly?Gln?Ser?Ala?Ser?Gln?Lys?Asn?Pro?Ile?Val

705 710 715 720

Glu?Tyr?Tyr?Gln?Glu?Ala?Tyr?Ala?Gly?Phe?Glu?Ala?Met?Lys?Glu?Gln

725 730 735

Ile?His?Ala?Asp?Met?Val?Arg?Asn?Leu?Leu?Met?Gly?Leu?Val?Glu?Val

740 745 750

Thr?Pro?Lys?Gly?Glu?Ile?Val?Thr?His?Phe?Pro

755 760

<210>64

<211>319

<212>PRT

＜213〉streptococcus pneumoniae

<400>64

Met?Ile?Gly?Thr?Phe?Ala?Ala?Ala?Leu?Val?Ala?Val?Leu?Ala?Asn?Phe

1 5 10 15

IIe?Val?Pro?Ile?Glu?Ile?Thr?Pro?Asn?Ser?Ala?Asn?Thr?Glu?Ile?Ala

20 25 30

Pro?Pro?Asp?Gly?Ile?Gly?Gln?Val?Leu?Ser?Asn?Leu?Leu?Leu?Lys?Leu

35 40 45

Val?Asp?Asn?Pro?Val?Asn?Ala?Leu?Leu?Thr?Ala?Asn?Tyr?Ile?Arg?Ile

50 55 60

Leu?Ser?Trp?Ala?Val?Ile?Phe?Gly?Ile?Ala?Met?Arg?Glu?Ala?Ser?Lys

65 70 75 80

Asn?Ser?Gln?Glu?Leu?Leu?Lys?Thr?Ile?Ala?Asp?Val?Thr?Ser?Lys?Ile

85 90 95

Val?Glu?Trp?Ile?Ile?Asn?Leu?Ala?Pro?Phe?Gly?Ile?Leu?Gly?Leu?Val

100 105 110

Phe?Lys?Thr?Ile?Ser?Asp?Lys?Gly?Val?Gly?Ser?Leu?Ala?Asn?Tyr?Gly

115 120 125

Ile?Leu?Leu?Val?Leu?Leu?Val?Thr?Thr?Met?Leu?Phe?Val?Ala?Pro?Val

130 135 140

Val?Asn?Pro?Leu?Ile?Ala?Phe?Phe?Phe?Met?Arg?Arg?Asn?Pro?Tyr?Pro

145 150 155 160

Leu?Val?Trp?Asn?Cys?Leu?Arg?Val?Ser?Gly?Val?Thr?Ala?Phe?Phe?Thr

165 170 175

Arg?Ser?Ser?Ala?Thr?Asn?Ile?Pro?Val?Asn?Met?Lys?Leu?Cys?His?Asp

180 185 190

Leu?Gly?Leu?Asn?Pro?Asp?Thr?Tyr?Ser?Val?Ser?Ile?Pro?Leu?Gly?Ser

195 200 205

Thr?Ile?Asn?Met?Ala?Gly?Val?Ala?Ile?Thr?Ile?Asn?Leu?Leu?Thr?Leu

210 215 220

Ala?Ala?Val?Asn?Thr?Leu?Gly?Ile?Pro?Val?Asp?Phe?Ala?Thr?Ala?Phe

225 230 235 240

Val?Leu?Ser?Val?Val?Ala?Ala?Ile?Ser?Ser?Cys?Asp?Ala?Ser?Gly?Ile

245 250 255

Ala?Gly?Gly?Ser?Leu?Leu?Leu?Ile?Pro?Val?Ala?Cys?Ser?Leu?Phe?Gly

260 265 270

Ile?Ser?Asn?Asp?Ile?Ala?Ile?Gln?Ile?Val?Gly?Val?Gly?Phe?Val?Ile

275 280 285

Gly?Val?Ile?Gln?Asp?Ser?Cys?Glu?Thr?Ala?Leu?Asn?Ser?Ser?Thr?Asp

290 295 300

Val?Leu?Phe?Thr?Ala?Val?Ala?Glu?Tyr?Ala?Ala?Thr?Arg?Lys?Lys

305 310 315

<210>65

<211>317

<212>PRT

＜213〉streptococcus pneumoniae

<400>65

Met?Ser?Ile?Ser?Gln?Arg?Thr?Thr?Lys?Leu?Ile?Leu?Ala?Thr?Cys?Leu

1 5 10 15

Ala?Cys?Leu?Leu?Ala?Tyr?Phe?Leu?Asn?Leu?Ser?Ser?Ala?Val?Ser?Ala

20 25 30

Gly?Ile?Ile?Ala?Leu?Leu?Ser?Leu?Ser?Asp?Thr?Arg?Arg?Ser?Thr?Leu

35 40 45

Lys?Leu?Ala?Arg?Asn?Arg?Leu?Phe?Ser?Met?Leu?Leu?Ala?Leu?Ala?Ile

50 55 60

Gly?Val?Leu?Ala?Phe?His?Leu?Ser?Gly?Phe?His?Ile?Trp?Ser?Leu?Gly

65 70 75 80

Leu?Tyr?Leu?Ala?Phe?Tyr?Val?Pro?Leu?Ala?Tyr?Lys?Met?Gly?Trp?Glu

85 90 95

Ile?Gly?Ile?Thr?Pro?Ser?Thr?Val?Leu?Val?Ser?His?Leu?Leu?Val?Gln

100 105 110

Glu?Ser?Thr?Ser?Pro?Asp?Leu?Leu?Val?Asn?Glu?Phe?Leu?Leu?Phe?Ala

115 120 125

Ile?Gly?Thr?Gly?Phe?Ala?Leu?Leu?Val?Asn?Leu?Tyr?Met?Pro?Ser?Arg

130 135 140

Glu?Glu?Glu?Ile?Gln?His?Tyr?His?Thr?Leu?Val?Glu?Glu?Lys?Leu?Lys

145 150 155 160

Asp?Ile?Leu?Gln?Arg?Phe?Lys?Tyr?Tyr?Leu?Ser?Arg?Gly?Asp?Gly?Arg

165 170 175

Asn?Arg?Ala?Gln?Leu?Val?Ala?Glu?Leu?Asp?Thr?Leu?Leu?Lys?Glu?Ala

180 185 190

Leu?Arg?Leu?Val?Tyr?Leu?Asp?His?Ser?Asp?His?Leu?Phe?His?Gln?Thr

195 200 205

Asp?Tyr?His?Ile?His?Tyr?Phe?Glu?Met?Arg?Gln?Arg?Gln?Ser?Arg?Ile

210 215 220

Leu?Arg?Asn?Met?Ala?Gln?Gln?Ile?Asn?Thr?Cys?His?Leu?Ala?Ala?Ser

225 230 235 240

Glu?Ser?Leu?Ile?Leu?Ala?Gln?Leu?Phe?Ser?Lys?Ile?Ala?Gly?Gln?Leu

245 250 255

Ser?Gln?Thr?Asn?Pro?Ala?Ser?Asp?Leu?Leu?Asp?Glu?Ile?Glu?Arg?Tyr

260 265 270

Leu?Glu?Val?Phe?Arg?Asn?Arg?Ser?Leu?Pro?Lys?Thr?Arg?Glu?Glu?Phe

275 280 285

Glu?Thr?Arg?Ala?Thr?Leu?Leu?Gln?Leu?Leu?Arg?Glu?Ala?Lys?Thr?Phe

290 295 300

Ile?Gln?Val?Lys?Val?Asp?Phe?Tyr?Gln?Lys?Tyr?Arg?Gln

305 310 315

<210>66

<211>537

<212>PRT

＜213〉streptococcus pneumoniae

<400>66

Met?Glu?Ile?Met?Ser?Leu?Ala?Ile?Ala?Val?Phe?Ala?Val?Ile?Ile?Gly

1 5 10 15

Leu?Val?Ile?Gly?Tyr?Val?Ser?Ile?Ser?Ala?Lys?Met?Lys?Ser?Ser?Gln

20 25 30

Glu?Ala?Ala?Glu?Leu?Met?Leu?Leu?Asn?Ala?Glu?Gln?Glu?Ala?Thr?Asn

35 40 45

Leu?Arg?Gly?Gln?Ala?Glu?Arg?Glu?Ala?Asp?Leu?Leu?Val?Asn?Glu?Ala

50 55 60

Lys?Arg?Glu?Ser?Lys?Ser?Leu?Lys?Lys?Glu?Ala?Leu?Leu?Glu?Ala?Lys

65 70 75 80

Glu?Glu?Ala?Arg?Lys?Tyr?Arg?Glu?Glu?Val?Asp?Ala?Glu?Phe?Lys?Ser

85 90 95

Glu?Arg?Gln?Glu?Leu?Lys?Gln?Ile?Glu?Ser?Arg?Leu?Thr?Glu?Arg?Ala

100 105 110

Thr?Ser?Leu?Asp?Arg?Lys?Asp?Asp?Asn?Leu?Thr?Ser?Lys?Glu?Gln?Thr

115 120 125

Leu?Glu?Gln?Lys?Glu?Gln?Ser?Ile?Ser?Asp?Arg?Ala?Lys?Asn?Leu?Asp

130 135 140

Ala?Arg?Glu?Glu?Gln?Leu?Glu?Glu?Val?Glu?Arg?Gln?Lys?Glu?Ala?Glu

145 150 155 160

Leu?Glu?Arg?Ile?Gly?Ala?Leu?Ser?Gln?Ala?Glu?Ala?Arg?Asp?Ile?Ile

165 170 175

Leu?Ala?Gln?Thr?Glu?Glu?Asn?Leu?Thr?Arg?Glu?Ile?Ala?Ser?Arg?Ile

180 185 190

Arg?Glu?Ala?Glu?Gln?Glu?Val?Lys?Glu?Arg?Ser?Asp?Lys?Met?Ala?Lys

195 200 205

Asp?Ile?Leu?Val?Gln?Ala?Met?Gln?Arg?Ile?Ala?Gly?Glu?Tyr?Val?Ala

210 215 220

Glu?Ser?Thr?Asn?Ser?Thr?Val?His?Leu?Pro?Asp?Asp?Thr?Met?Lys?Gly

225 230 235 240

Arg?Ile?Ile?Gly?Arg?Glu?Gly?Arg?Asn?Ile?Arg?Thr?Phe?Glu?Ser?Leu

245 250 255

Thr?Gly?Val?Asp?Val?Ile?Ile?Asp?Asp?Thr?Pro?Glu?Val?Val?Thr?Leu

260 265 270

Ser?Gly?Phe?Asp?Pro?Ile?Arg?Arg?Glu?Ile?Ala?Arg?Met?Thr?Met?Glu

275 280 285

Met?Leu?Leu?Lys?Asp?Gly?Arg?Ile?His?Pro?Ala?Arg?Ile?Glu?Glu?Leu

290 295 300

Val?Glu?Lys?Asn?Arg?Gln?Glu?Ile?Asp?Asn?Lys?Ile?Arg?Glu?Tyr?Gly

305 310 315 320

Glu?Ala?Ala?Ala?Tyr?Glu?Ile?Gly?Ala?Pro?Asn?Leu?His?Pro?Asp?Leu

325 330 335

Met?Lys?Ile?Met?Gly?Arg?Leu?Gln?Phe?Arg?Thr?Ser?Tyr?Gly?Gln?Asn

340 345 350

Val?Leu?Arg?His?Ser?Ile?Glu?Val?Ala?Lys?Leu?Ala?Gly?Ile?Met?Ala

355 360 365

Ser?Glu?Leu?Gly?Glu?Asn?Ala?Ala?Leu?Ala?Arg?Arg?Ala?Gly?Phe?Leu

370 375 380

His?Asp?Ile?Gly?Lys?Ala?Ile?Asp?His?Glu?Val?Glu?Gly?Ser?His?Val

385 390 395 400

Glu?Ile?Gly?Met?Glu?Leu?Ala?Arg?Lys?Tyr?Lys?Glu?Pro?Pro?Val?Val

405 410 415

Val?Asn?Thr?Ile?Ala?Ser?His?His?Gly?Asp?Val?Glu?Ala?Glu?Ser?Val

420 425 430

Ile?Ala?Val?Ile?Val?Ala?Ala?Ala?Asp?Ala?Leu?Ser?Ala?Ala?Arg?Pro

435 440 445

Gly?Ala?Arg?Ser?Glu?Ser?Leu?Glu?Ser?Tyr?Ile?Lys?Arg?Leu?His?Asp

450 455 460

Leu?Glu?Glu?Ile?Ala?Asn?Gly?Phe?Glu?Gly?Val?Gln?Thr?Ser?Phe?Ala

465 470 475 480

Leu?Gln?Ala?Gly?Arg?Glu?Ile?Arg?Ile?Met?Val?Asn?Pro?Gly?Lys?Ile

485 490 495

Lys?Asp?Asp?Lys?Val?Thr?Ile?Leu?Ala?His?Lys?Val?Arg?Lys?Lys?Ile

500 505 510

Glu?Asn?Asn?Leu?Asp?Tyr?Pro?Gly?Asn?Ile?Lys?Val?Thr?Val?Ile?Arg

515 520 525

Glu?Leu?Arg?Ala?Val?Asp?Tyr?Ala?Lys

530 535

<210>67

<211>104

<212>PRT

＜213〉streptococcus pneumoniae

<400>67

Met?Met?Leu?Lys?Pro?Ser?Ile?Asp?Thr?Leu?Leu?Asp?Lys?Val?Pro?Ser

1 5 10 15

Lys?Tyr?Ser?Leu?Val?Ile?Leu?Glu?Ala?Lys?Arg?Ala?His?Glu?Leu?Glu

20 25 30

Ala?Gly?Ala?Pro?Ala?Thr?Gln?Gly?Phe?Lys?Ser?Glu?Lys?Ser?Thr?Leu

35 40 45

Arg?Ala?Leu?Glu?Glu?Ile?Glu?Ser?Gly?Asn?Val?Thr?Ile?His?Pro?Asp

50 55 60

Pro?Glu?Gly?Lys?Arg?Glu?Ala?Val?Arg?Arg?Arg?Ile?Glu?Glu?Glu?Lys

65 70 75 80

Arg?Arg?Lys?Glu?Glu?Glu?Glu?Lys?Lys?Ile?Lys?Glu?Gln?Ile?Ala?Lys

85 90 95

Glu?Lys?Glu?Asp?Gly?Glu?Lys?Ile

100

<210>68

<211>263

<212>PRT

＜213〉streptococcus pneumoniae

<400>68

Met?Ser?Ala?Tyr?Gln?Leu?Pro?Thr?Val?Trp?Gln?Asp?Glu?Ala?Ser?Asn

1 5 10 15

Gln?Gly?Ala?Phe?Thr?Gly?Leu?Asn?Arg?Pro?Thr?Ala?Gly?Ala?Arg?Phe

20 25 30

Glu?Gln?Asn?Leu?Pro?Lys?Gly?Glu?Gln?Ala?Phe?Gln?Leu?Tyr?Ser?Leu

35 40 45

Gly?Thr?Pro?Asn?Gly?Val?Lys?Val?Thr?Ile?Leu?Leu?Glu?Glu?Leu?Leu

50 55 60

Glu?Ala?Gly?Phe?Lys?Glu?Ala?Ala?Tyr?Asp?Leu?Tyr?Lys?Ile?Ala?Ile

65 70 75 80

Met?Asp?Gly?Asp?Gln?Phe?Gly?Ser?Asp?Phe?Val?Lys?Leu?Asn?Pro?Asn

85 90 95

Ser?Lys?Ile?Pro?ALa?Leu?Leu?Asp?Gln?Ser?Gly?Thr?Glu?Asn?Val?Arg

100 105 110

Val?Phe?Glu?Ser?Ala?His?Ile?Leu?Leu?Tyr?Leu?Ala?Glu?Lys?Phe?Gly

115 120 125

Ala?Phe?Leu?Pro?Ser?Asn?Pro?Val?Glu?Lys?Val?Glu?Val?Leu?Asn?Trp

130 135 140

Leu?Phe?Trp?Gln?Ala?Gly?Ala?Ala?Pro?Phe?Leu?Gly?Gly?Gly?Phe?Gly

145 150 155 160

His?Phe?Phe?Asn?Tyr?Ala?Pro?Glu?Lys?Leu?Glu?Tyr?Pro?Ile?Asn?Arg

165 170 175

Phe?Thr?Met?Glu?Val?Lys?Arg?Gln?Leu?Asp?Leu?Leu?Asp?Lys?Glu?Leu

180 185 190

Ala?Gln?Lys?Pro?Tyr?Ile?Ala?Gly?Asn?Asp?Tyr?Thr?Ile?Ala?Asp?Ile

195 200 205

Ala?Ile?Trp?Ser?Trp?Tyr?Gly?Gln?Leu?Val?Gln?Gly?Asn?Leu?Tyr?Gln

210 215 220

Gly?Ser?Ala?Lys?Phe?Leu?Asp?Ala?Ser?Ser?Tyr?Gln?Asn?Leu?Val?Lys

225 230 235 240

Trp?Ala?Glu?Lys?Ile?Ala?Asn?Arg?Pro?Ala?Val?Lys?Arg?Gly?Leu?Glu

245 250 255

Val?Thr?Tyr?Thr?Glu?Ile?Lys

260

<210>69

<211>312

<212>PRT

＜213〉streptococcus pneumoniae

<400>69

Leu?Ala?Ser?Leu?Ile?Thr?Ser?Ile?Ile?Met?Phe?Tyr?Val?Gly?Phe?Asp

1 5 10 15

Val?Leu?Arg?Asp?Thr?Ile?Gln?Lys?Ile?Leu?Ser?Arg?Glu?Glu?Thr?Val

20 25 30

Ile?Asp?Pro?Leu?Gly?Ala?Thr?Leu?Gly?Ile?Ile?Ser?Ala?Ala?Ile?Met

35 40 45

Phe?Val?Val?Tyr?Leu?Tyr?Asn?Thr?Arg?Leu?Ser?Lys?Lys?Ser?Asn?Ser

50 55 60

Asn?Ala?Leu?Lys?Ala?Ala?Ala?Lys?Asp?Asn?Leu?Ser?Asp?Ala?Val?Thr

65 70 75 80

Ser?Leu?Gly?Thr?Ala?Ile?Ala?Ile?Leu?Ala?Ser?Ser?Phe?Asn?Tyr?Pro

85 90 95

Ile?Val?Asp?Lys?Leu?Val?Ala?Ile?Ile?Ile?Thr?Phe?Phe?Ile?Leu?Lys

100 105 110

Thr?Ala?Tyr?Asp?Ile?Phe?Ile?Glu?Ser?Ser?Phe?Ser?Leu?Ser?Asp?Gly

115 120 125

Phe?Asp?Asp?Arg?Leu?Leu?Glu?Asp?Tyr?Gln?Lys?Ala?Ile?Met?Glu?Ile

130 135 140

Pro?Lys?Ile?Ser?Lys?Val?Lys?Ser?Gln?Arg?Gly?Arg?Thr?Tyr?Gly?Ser

145 150 155 160

Asn?Ile?Tyr?Leu?Asp?Ile?Thr?Leu?Glu?Met?Asn?Pro?Asp?Leu?Ser?Val

165 170 175

Phe?Glu?Ser?His?Glu?Ile?Ala?Asp?Gln?Val?Glu?Ser?Met?Leu?Glu?Glu

180 185 190

Arg?Phe?Gly?Val?Phe?Asp?Thr?Asp?Val?His?Ile?Glu?Pro?Ala?Pro?Ile

195 200 205

Pro?Glu?Asp?Glu?Ile?Leu?Asp?Asn?Val?Tyr?Lys?Lys?Leu?Leu?Met?Arg

210 215 220

Glu?Gln?Leu?Ile?Asp?Gln?Gly?Asn?Gln?Leu?Glu?Glu?Leu?Leu?Thr?Asp

225 230 235 240

Asp?Phe?Val?Tyr?Ile?Arg?Gln?Asp?Gly?Glu?Gln?Met?Asp?Lys?Glu?Ala

245 250 255

Tyr?Lys?Thr?Lys?Lys?Glu?Leu?Asn?Ser?Ala?Ile?Lys?Asp?Ile?Gln?Ile

260 265 270

Thr?Ser?Ile?Ser?Gln?Lys?Thr?Lys?Leu?Ile?Cys?Tyr?Glu?Leu?Asp?Gly

275 280 285

Ile?Ile?His?Thr?Ser?Ile?Trp?Arg?Arg?His?Glu?Thr?Trp?Gln?Asn?Ile

290 295 300

Phe?His?Gln?Glu?Thr?Lys?Lys?Glu

305 310

<210>70

<211>264

<212>PRT

＜213〉streptococcus pneumoniae

<400>70

Met?Thr?Ile?Lys?Leu?Val?Ala?Thr?Asp?Met?Asp?Gly?Thr?Phe?Leu?Asp

1 5 10 15

Gly?Asn?Gly?Arg?Phe?Asp?Met?Asp?Arg?Leu?Lys?Ser?Leu?Leu?Val?Ser

20 25 30

Tyr?Lys?Glu?Lys?Gly?Ile?Tyr?Phe?Ala?Val?Ala?Ser?Gly?Arg?Gly?Phe

35 40 45

Leu?Ser?Leu?Glu?Lys?Leu?Phe?Ala?Gly?Val?Arg?Asp?Asp?Ile?Ile?Phe

50 55 60

Ile?Ala?Glu?Asn?Gly?Ser?Leu?Val?Glu?Tyr?Gln?Gly?Gln?Asp?Leu?Tyr

65 70 75 80

Glu?Ala?Thr?Met?Ser?Arg?Asp?Phe?Tyr?Leu?Ala?Thr?Phe?Glu?Lys?Leu

85 90 95

Lys?Thr?Ser?Pro?Tyr?Val?Asp?Ile?Asn?Lys?Leu?Leu?Leu?Thr?Gly?Lys

100 105 110

Lys?Gly?Ser?Tyr?Val?Leu?Asp?Thr?Val?Asp?Glu?Thr?Tyr?Leu?Lys?Val

115 120 125

Ser?Gln?His?Tyr?Asn?Glu?Asn?Ile?Gln?Lys?Val?Ala?Ser?Leu?Glu?Asp

130 135 140

Ile?Thr?Asp?Asp?Ile?Phe?Lys?Phe?Thr?Thr?Asn?Phe?Thr?Glu?Glu?Thr

145 150 155 160

Leu?Glu?Asp?Gly?Glu?Ala?Trp?Val?Asn?Glu?Asn?Val?Pro?Gly?Val?Lys

165 170 175

Ala?Met?Thr?Thr?Gly?Phe?Glu?Ser?Ile?Asp?Ile?Val?Leu?Asp?Tyr?Val

180 185 190

Asp?Lys?Gly?Val?Ala?Ile?Val?Glu?Leu?Val?Lys?Lys?Leu?Gly?Ile?Thr

195 200 205

Met?Asp?Gln?Val?Met?Ala?Phe?Gly?Asp?Asn?Leu?Asn?Asp?Leu?His?Met

210 215 220

Met?Gln?Val?Val?Gly?His?Pro?Val?Ala?Pro?Glu?Asn?Ala?Arg?Pro?Glu

225 230 235 240

Ile?Leu?Glu?Leu?Ala?Lys?Thr?Val?Ile?Gly?His?His?Lys?Glu?Arg?Ser

245 250 255

Val?Ile?Ala?Tyr?Met?Glu?Gly?Leu

260

<210>71

<211>272

<212>PRT

＜213〉streptococcus pneumoniae

<400>71

Met?Ala?Asp?Ile?Lys?Leu?Ile?Ala?Leu?Asp?Leu?Asp?Gly?Thr?Leu?Leu

1 5 10 15

Thr?Thr?Asp?Lys?Arg?Leu?Thr?Asp?Arg?Thr?Lys?Glu?Thr?Leu?Gln?Ala

20 25 30

Ala?Arg?Asp?Arg?Gly?Ile?Lys?Val?Val?Leu?Thr?Thr?Gly?Arg?Pro?Leu

35 40 45

Lys?Ala?Met?Asp?Phe?Phe?Leu?His?Glu?Leu?Gly?Thr?Asp?Gly?Gln?Glu

50 55 60

Asp?Glu?Tyr?Thr?Ile?Thr?Phe?Asn?Gly?Gly?Leu?Val?Gln?Lys?Asn?Thr

65 70 75 80

Gly?Glu?Ile?Leu?Asp?Lys?Thr?Val?Phe?Ser?Tyr?Asp?Asp?Val?Ala?Arg

85 90 95

Leu?Tyr?Glu?Glu?Thr?Glu?Lys?Leu?Ser?Leu?Pro?Leu?Asp?Ala?Ile?Ser

100 105 110

Glu?Gly?Thr?Val?Tyr?Gln?Ile?Gln?Ser?Asp?Gln?Glu?Ser?Leu?Tyr?Ala

115 120 125

Lys?Phe?Asn?Pro?Ala?Leu?Thr?Phe?Val?Pro?Val?Asp?Phe?Glu?Asp?Leu

130 135 140

Ser?Ser?Gln?Met?Thr?Tyr?Asn?Lys?Cys?Val?Thr?Ala?Phe?Ala?Gln?Glu

145 150 155 160

Pro?Leu?Asp?Ala?Ala?Ile?Gln?Lys?Ile?Ser?Pro?Glu?Leu?Phe?Asp?Gln

165 170 175

Tyr?Glu?Ile?Phe?Lys?Ser?Arg?Glu?Met?Leu?Leu?Glu?Trp?Ser?Pro?Lys

180 185 190

Asn?Val?His?Lys?Ala?Thr?Gly?Leu?Ala?Lys?Leu?Ile?Ser?His?Leu?Gly

195 200 205

Ile?Asp?Gln?Ser?Gln?Val?Met?Ala?Cys?Gly?Asp?Glu?Ala?Asn?Asp?Leu

210 215 220

Ser?Met?Ile?Glu?Trp?Ala?Gly?Leu?Gly?Val?Ala?Met?Gln?Asn?Ala?Val

225 230 235 240

Pro?Glu?Val?Lys?Ala?Ala?Ala?Asn?Val?Val?Thr?Pro?Met?Thr?Asn?Asp

245 250 255

Glu?Glu?Ala?Val?Ala?Trp?Ala?Ile?Glu?Glu?Tyr?Val?Leu?Lys?Glu?Asn

260 265 270

<210>72

<211>418

<212>PRT

＜213〉streptococcus pneumoniae

<400>72

Met?Glu?Ser?Leu?Leu?Ile?Leu?Leu?Leu?Ile?Ala?Asn?Leu?Ala?Gly?Leu

1 5 10 15

Phe?Leu?Ile?Trp?Gln?Arg?Gln?Asp?Arg?Gln?Glu?Lys?His?Leu?Ser?Lys

20 25 30

Ser?Leu?Glu?Asp?Gln?Ala?Asp?His?Leu?Ser?Asp?Gln?Leu?Asp?Tyr?Arg

35 40 45

Phe?Asp?Gln?Ala?Arg?Gln?Ala?Ser?Gln?Leu?Asp?Gln?Lys?Asp?Leu?Glu

50 55 60

Val?Val?Val?Ser?Asp?Arg?Leu?Gln?Glu?Val?Arg?Ile?Glu?Leu?His?Gln

65 70 75 80

Gly?Leu?Thr?Gln?Val?Arg?Gln?Glu?Met?Thr?Asp?Asn?Leu?Leu?Gln?Thr

85 90 95

Arg?Asp?Lys?Thr?Asp?Gln?Arg?Leu?Gln?Ala?Leu?Gln?Glu?Ser?Asn?Glu

100 105 110

Gln?Arg?Leu?Glu?Gln?Met?Arg?Gln?Thr?Val?Glu?Glu?Lys?Leu?Glu?Lys

115 120 125

Thr?Leu?Gln?Thr?Arg?Leu?Gln?Ala?Ser?Phe?Glu?Thr?Val?Ser?Lys?Gln

130 135 140

Leu?Glu?Ser?Val?Asn?Arg?Gly?Leu?Gly?Glu?Met?Gln?Thr?Val?Ala?Arg

145 150 155 160

Asp?Val?Gly?Ala?Leu?Asn?Lys?Val?Leu?Ser?Gly?Thr?Lys?Thr?Arg?Gly

165 170 175

Ile?Leu?Gly?Glu?Leu?Gln?Leu?Gly?Gln?Ile?Ile?Glu?Asp?Ile?Met?Thr

180 185 190

Pro?Ala?Gln?Tyr?Glu?Arg?Glu?Tyr?Ala?Thr?Val?Glu?Asn?Ser?Ser?Glu

195 200 205

Arg?Val?Glu?Tyr?Ala?Ile?Lys?Leu?Pro?Gly?Gln?Gly?Asp?Gln?Glu?Tyr

210 215 220

Val?Tyr?Leu?Pro?Ile?Asp?Ser?Lys?Phe?Pro?Leu?Ala?Asp?Tyr?Tyr?Arg

225 230 235 240

Leu?Glu?Glu?Ala?Tyr?Glu?Thr?Gly?Asp?Lys?Asp?Glu?Ile?Glu?Arg?Cys

245 250 255

Arg?Lys?Ser?Leu?Leu?Ala?Ser?Val?Lys?Arg?Phe?Ala?Arg?Asp?Ile?Arg

260 265 270

Asn?Lys?Tyr?Ile?Ala?Pro?Pro?Arg?Thr?Thr?Asn?Phe?Gly?Val?Leu?Phe

275 280 285

Val?Pro?Thr?Glu?Gly?Leu?Tyr?Ser?Glu?Ile?Val?Arg?Asn?Pro?Val?Phe

290 295 300

Phe?Asp?Asp?Leu?Arg?Arg?Glu?Glu?Gln?Ile?Ile?Val?Ala?Gly?Pro?Ser

305 310 315 320

Thr?Leu?Ser?Ala?Leu?Leu?Asn?Ser?Leu?Ser?Val?Gly?Phe?Lys?Thr?Leu

325 330 335

Asn?Ile?Gln?Lys?Ser?Ala?Asp?His?Ile?Ser?Lys?Thr?Leu?Ala?Ser?Val

340 345 350

Lys?Thr?Glu?Phe?Gly?Lys?Phe?Gly?Gly?Ile?Leu?Val?Lys?Ala?Gln?Lys

355 360 365

His?Leu?Gln?His?Ala?Ser?Gly?Asn?Ile?Asp?Glu?Leu?Leu?Asn?Arg?Arg

370 375 380

Thr?Ile?Ala?Ile?Glu?Arg?Thr?Leu?Arg?His?Ile?Glu?Leu?Ser?Glu?Gly

385 390 395 400

Glu?Pro?Ala?Leu?Asp?Leu?Leu?His?Phe?Gln?Glu?Asn?Glu?Glu?Glu?Tyr

405 410 415

Glu?Asp

<210>73

<211>313

<212>PRT

＜213〉streptococcus pneumoniae

<400>73

Met?Lys?Ile?Ser?His?Met?Lys?Lys?Asp?Glu?Leu?Phe?Glu?Gly?Phe?Tyr

1 5 10 15

Leu?Ile?Lys?Ser?Ala?Asp?Leu?Arg?Gln?Thr?Arg?Ala?Gly?Lys?Asn?Tyr

20 25 30

Leu?Ala?Phe?Thr?Phe?Gln?Asp?Asp?Ser?Gly?Glu?Ile?Asp?Gly?Lys?Leu

35 40 45

Trp?Asp?Ala?Gln?Pro?His?Asn?Ile?Glu?Ala?Phe?Thr?Ala?Gly?Lys?Val

50 55 60

Val?His?Met?Lys?Gly?Arg?Arg?Glu?Val?Tyr?Asn?Asn?Thr?Pro?Gln?Val

65 70 75 80

Asn?Gln?Ile?Thr?Leu?Arg?Leu?Pro?Gln?Ala?Gly?Glu?Pro?Asn?Asp?Pro

85 90 95

Ala?Asp?Phe?Lys?Val?Lys?Ser?Pro?Val?Asp?Val?Lys?Glu?Ile?Arg?Asp

100 105 110

Tyr?Met?Ser?Gln?Met?Ile?Phe?Lys?Ile?Glu?Asn?Pro?Val?Trp?Gln?Arg

115 120 125

Ile?Val?Arg?Asn?Leu?Tyr?Thr?Lys?Tyr?Asp?Lys?Glu?Phe?Tyr?Ser?Tyr

130 135 140

Pro?Ala?Ala?Lys?Thr?Asn?His?His?Ala?Phe?Glu?Thr?Gly?Leu?Ala?Tyr

145 150 155 160

His?Thr?Ala?Thr?Met?Val?Arg?Leu?Ala?Asp?Ala?Ile?Ser?Glu?Val?Tyr

165 170 175

Pro?Gln?Leu?Asn?Lys?Ser?Leu?Leu?Tyr?Ala?Gly?Ile?Met?Leu?His?Asp

180 185 190

Leu?Ala?Lys?Val?Ile?Glu?Leu?Thr?Gly?Pro?Asp?Gln?Thr?Glu?Tyr?Thr

195 200 205

Val?Arg?Gly?Asn?Leu?Leu?Gly?His?Ile?Ala?Leu?Ile?Asp?Ser?Glu?Ile

210 215 220

Thr?Lys?Thr?Val?Met?Glu?Leu?Gly?Ile?Asp?Asp?Thr?Lys?Glu?Glu?Val

225 230 235 240

Val?Leu?Leu?Arg?His?Val?Ile?Leu?Ser?His?His?Gly?Leu?Leu?Glu?Tyr

245 250 255

Gly?Ser?Pro?Val?Arg?Pro?Arg?Ile?Met?Glu?Ala?Glu?Ile?Ile?His?Met

260 265 270

Ile?Asp?Asn?Leu?Asp?Ala?Ser?Met?Met?Met?Met?Ser?Thr?Ala?Leu?Ala

275 280 285

Leu?Val?Asp?Lys?Gly?Glu?Met?Thr?Asn?Lys?Ile?Phe?Ala?Met?Asp?Asn

290 295 300

Arg?Ser?Phe?Tyr?Lys?Pro?Asp?Leu?Asp

305 310

<210>74

<211>503

<212>PRT

＜213〉streptococcus pneumoniae

<400>74

Met?Ser?Glu?Lys?Ala?Lys?Lys?Gly?Phe?Lys?Met?Pro?Ser?Ser?Tyr?Thr

1 5 10 15

Val?Leu?Leu?Ile?Ile?Ile?Ala?Ile?Met?Ala?Val?Leu?Thr?Trp?Phe?Ile

20 25 30

Pro?Ala?Gly?Ala?Phe?Ile?Glu?Gly?Ile?Tyr?Glu?Thr?Gln?Pro?Gln?Asn

35 40 45

Pro?Gln?Gly?Ile?Trp?Asp?Val?Leu?Met?Ala?Pro?Ile?Arg?Ala?Met?Leu

50 55 60

Gly?Thr?His?Pro?Glu?Glu?Gly?Ser?Leu?Ile?Lys?Glu?Thr?Ser?Ala?Ala

65 70 75 80

Ile?Asp?Val?Ala?Phe?Phe?Ile?Leu?Met?Val?Gly?Gly?Phe?Leu?Gly?Ile

85 90 95

Val?Asn?Lys?Thr?Gly?Ala?Leu?Asp?Val?Gly?Ile?Ala?Ser?Ile?Val?Lys

100 105 110

Lys?Tyr?Lys?Gly?Arg?Glu?Lys?Met?Leu?Ile?Leu?Val?Leu?Met?Pro?Leu

115 120 125

Phe?Ala?Leu?Gly?Gly?Thr?Thr?Tyr?Gly?Met?Gly?Glu?Glu?Thr?Met?Ala

130 135 140

Phe?Tyr?Pro?Leu?Leu?Val?Pro?Val?Met?Met?Ala?Val?Gly?Phe?Asp?Ser

145 150 155 160

Leu?Thr?Gly?Val?Ala?Ile?Ile?Leu?Leu?Gly?Ser?Gln?Ile?Gly?Cys?Leu

165 170 175

Ala?Ser?Thr?Leu?Asn?Pro?Phe?Ala?Thr?Gly?Ile?Ala?Ser?Ala?Thr?Ala

180 185 190

Gly?Val?Gly?Thr?Gly?Asp?Gly?Ile?Val?Leu?Arg?Leu?Ile?Phe?Trp?Val

195 200 205

Thr?Leu?Thr?Ala?Leu?Ser?Thr?Trp?Phe?Val?Tyr?Arg?Tyr?Ala?Asp?Lys

210 215 220

Ile?Gln?Lys?Asp?Pro?Thr?Lys?Ser?Leu?Val?Tyr?Ser?Thr?Arg?Lys?Glu

225 230 235 240

Asp?Leu?Lys?His?Phe?Asn?Val?Glu?Glu?Ser?Ser?Ser?Val?Glu?Ser?Thr

245 250 255

Leu?Ser?Ser?Lys?Gln?Lys?Ser?Val?Leu?Phe?Leu?Phe?Val?Leu?Thr?Phe

260 265 270

Ile?Leu?Met?Val?Leu?Ser?Phe?Ile?Pro?Trp?Thr?Asp?Leu?Gly?Val?Thr

275 280 285

Ile?Phe?Asp?Asp?Phe?Asn?Thr?Trp?Leu?Thr?Gly?Leu?Pro?Val?Ile?Gly

290 295 300

Asn?Ile?Val?Gly?Ser?Ser?Thr?Ser?Ala?Leu?Gly?Thr?Trp?Tyr?Phe?Pro

305 310 315 320

Glu?Gly?Ala?Met?Leu?Phe?Ala?Phe?Met?Gly?Ile?Leu?Ile?Gly?Val?Ile

325 330 335

Tyr?Gly?Leu?Lys?Glu?Asp?Lys?Ile?Ile?Ser?Ser?Phe?Met?Asn?Gly?Ala

340 345 350

Ala?Asp?Leu?Leu?Ser?Val?Ala?Leu?Ile?Val?Ala?Ile?Ala?Arg?Gly?Ile

355 360 365

Gln?Val?Ile?Met?Asn?Asp?Gly?Met?Ile?Thr?Asp?Thr?Ile?Leu?Asn?Trp

370 375 380

Gly?Lys?Glu?Gly?Leu?Ser?Gly?Leu?Ser?Ser?Gln?Val?Phe?Ile?Val?Val

385 390 395 400

Thr?Tyr?Ile?Phe?Tyr?Leu?Pro?Met?Ser?Phe?Leu?Ile?Pro?Ser?Ser?Ser

405 410 415

Gly?Leu?Ala?Ser?Ala?Thr?Met?Gly?Ile?Met?Ala?Pro?Leu?Gly?Glu?Phe

420 425 430

Val?Asn?Val?Arg?Pro?Ser?Leu?Ile?Ile?Thr?Ala?Tyr?Gln?Ser?Ala?Ser

435 440 445

Gly?Val?Leu?Asn?Leu?Ile?Ala?Pro?Thr?Ser?Gly?Ile?Val?Met?Gly?Ala

450 455 460

Leu?Ala?Leu?Gly?Arg?Ile?Asn?Ile?Gly?Thr?Trp?Trp?Lys?Phe?Met?Gly

465 470 475 480

Lys?Leu?Val?Val?Ala?Ile?Ile?Val?Val?Thr?Ile?Ala?Leu?Leu?Leu?Leu

485 490 495

Gly?Thr?Phe?Leu?Pro?Phe?Leu

500

<210>75

<211>782

<212>PRT

＜213〉streptococcus pneumoniae

<400>75

Met?Ser?Asn?Ser?Phe?Val?Lys?Leu?Leu?Val?Ser?Gln?Leu?Phe?Ala?Asn

1 5 10 15

Leu?Ala?Asp?Ile?Phe?Phe?Arg?Val?Thr?Ile?Ile?Ala?Asn?Ile?Tyr?Ile

20 25 30

Ile?Ser?Lys?Ser?Val?Ile?Ala?Thr?Ser?Leu?Val?Pro?Ile?Leu?Ile?Gly

35 40 45

Ile?Ser?Ser?Phe?Val?Ala?Ser?Leu?Leu?Val?Pro?Leu?Val?Thr?Lys?Arg

50 55 60

Leu?Ala?Leu?Asn?Arg?Val?Leu?Ser?Leu?Ser?Gln?Phe?Gly?Lys?Thr?Ile

65 70 75 80

Leu?Leu?Ala?Ile?Leu?Val?Gly?Met?Phe?Thr?Val?Met?Gln?Ser?Val?Ala

85 90 95

Pro?Leu?Val?Thr?Tyr?Leu?Phe?Val?Val?Ala?Ile?Ser?Ile?Leu?Asp?Gly

100 105 110

Phe?Ala?Ala?Pro?Val?Ser?Tyr?Ala?Ile?Val?Pro?Arg?Tyr?Ala?Thr?Asp

115 120 125

Leu?Gly?Lys?Ala?Asn?Ser?Ala?Leu?Ser?Met?Thr?Gly?Glu?Ala?Val?Gln

130 135 140

Leu?Ile?Gly?Trp?Gly?Leu?Gly?Gly?Leu?Leu?Phe?Ala?Thr?Ile?Gly?Leu

145 150 155 160

Leu?Pro?Thr?Thr?Cys?Ile?Asn?Leu?Val?Leu?Tyr?Ile?Ile?Ser?Ser?Phe

165 170 175

Leu?Met?Leu?Phe?Leu?Pro?Asn?Ala?Glu?Val?Glu?Val?Leu?Glu?Ser?Glu

180 185 190

Thr?Asn?Leu?Glu?Ile?Leu?Leu?Lys?Gly?Trp?Lys?Leu?Val?Ala?Arg?Asn

195 200 205

Pro?Arg?Leu?Arg?Leu?Phe?Val?Ser?Ala?Asn?Leu?Leu?Glu?Ile?Phe?Ser

210 215 220

Asn?Thr?Ile?Trp?Val?Ser?Ser?Ile?Ile?Leu?Val?Phe?Val?Thr?Glu?Leu

225 230 235 240

Leu?Asn?Lys?Thr?Glu?Ser?Tyr?Trp?Gly?Tyr?Ser?Asn?Thr?Ala?Tyr?Ser

245 250 255

Ile?Gly?Ile?Ile?Ile?Ser?Gly?Leu?Ile?Ala?Phe?Arg?Leu?Ser?Glu?Lys

260 265 270

Phe?Leu?Ala?Ala?Lys?Trp?Glu?Pro?Gln?Leu?Phe?Thr?Pro?Asn?Leu?Lys

275 280 285

Thr?Ile?Gln?Asn?Pro?Cys?Leu?Ser?Leu?Asp?Pro?Gly?Trp?Phe?Leu?Phe

290 295 300

Ser?Pro?Asn?Gly?Cys?Phe?Leu?Leu?Asp?Lys?Lys?Glu?Phe?Pro?Leu?Tyr

305 310 315 320

Gly?Ile?Ser?Val?Glu?Lys?Asn?Thr?Lys?Arg?Lys?Glu?Thr?His?Met?Asn

325 330 335

Ser?Leu?Pro?Asn?His?His?Phe?Gln?Asn?Lys?Ser?Phe?Tyr?Gln?Leu?Ser

340 345 350

Phe?Asp?Gly?Gly?His?Leu?Thr?Gln?Tyr?Gly?Gly?Leu?Ile?Phe?Phe?Gln

355 360 365

Glu?Leu?Phe?Ser?Gln?Leu?Lys?Leu?Lys?Glu?Arg?Ile?Ser?Lys?Tyr?Leu

370 375 380

Val?Thr?Asn?Asp?Gln?Arg?Arg?Tyr?Cys?Arg?Tyr?Ser?Asp?Ser?Asp?Ile

385 390 395 400

Leu?Val?Gln?Phe?Leu?Phe?Gln?Leu?Leu?Thr?Gly?Tyr?Gly?Thr?Asp?Tyr

405 410 415

Ala?Cys?Lys?Glu?Leu?Ser?Ala?Asp?Ala?Tyr?Phe?Pro?Lys?Leu?Leu?Glu

420 425 430

Gly?Gly?Gln?Leu?Ala?Ser?Gln?Pro?Thr?Leu?Ser?Arg?Phe?Leu?Ser?Arg

435 440 445

Thr?Asp?Glu?Glu?Thr?Val?His?Ser?Leu?Arg?Cys?Leu?Asn?Leu?Glu?Leu

450 455 460

Val?Glu?Phe?Phe?Leu?Gln?Phe?His?Gln?Leu?Asn?Gln?Leu?Ile?Val?Asp

465 470 475 480

Ile?Asp?Ser?Thr?His?Phe?Thr?Thr?Tyr?Gly?Lys?Gln?Glu?Gly?Val?Ala

485 490 495

Tyr?Asn?Ala?His?Tyr?Arg?Ala?His?Gly?Tyr?His?Pro?Leu?Tyr?Ala?Phe

500 505 510

Glu?Gly?Lys?Thr?Gly?Tyr?Cys?Phe?Asn?Ala?Gln?Leu?Arg?Pro?Gly?Asn

515 520 525

Arg?Tyr?Cys?Ser?Glu?Glu?Ala?Asp?Ser?Phe?Ile?Thr?Pro?Val?Leu?Glu

530 535 540

Arg?Phe?Asn?Gln?Leu?Leu?Phe?Arg?Met?Asp?Ser?Gly?Phe?Ala?Thr?Pro

545 550 555 560

Lys?Leu?Tyr?Asp?Leu?Ile?Glu?Lys?Thr?Gly?Gln?Tyr?Tyr?Leu?Ile?Lys

565 570 575

Leu?Lys?Lys?Asn?Thr?Val?Leu?Ser?Arg?Leu?Gly?Asp?Leu?Ser?Leu?Pro

580 585 590

Cys?Pro?Gln?Asp?Glu?Asp?Leu?Thr?Ile?Leu?Pro?His?Ser?Ala?Tyr?Ser

595 600 605

Glu?Thr?Leu?Tyr?Gln?Ala?Gly?Ser?Trp?Ser?His?Lys?Arg?Arg?Val?Cys

610 615 620

Gln?Phe?Ser?Glu?Arg?Lys?Glu?Gly?Asn?Leu?Phe?Tyr?Asp?Val?Ile?Ser

625 630 635 640

Leu?Val?Thr?Asn?Met?Thr?Ser?Gly?Thr?Ser?Gln?Asp?Gln?Phe?Gln?Leu

645 650 655

Tyr?Arg?Gly?Arg?Gly?Gln?Ala?Glu?Asn?Phe?Ile?Lys?Glu?Met?Lys?Glu

660 665 670

Gly?Phe?Phe?Gly?Asp?Lys?Thr?Asp?Ser?Ser?Thr?Leu?Ile?Lys?Asn?Glu

675 680 685

Val?Arg?Met?Met?Met?Ser?Cys?Ile?Ala?Tyr?Asn?Leu?Tyr?Leu?Phe?Leu

690 695 700

Lys?His?Leu?Ala?Gly?Gly?Asp?Phe?Gln?Thr?Leu?Thr?Ile?Lys?Arg?Phe

705 710 715 720

Arg?His?Leu?Phe?Leu?His?Val?Val?Gly?Lys?Cys?Val?Arg?Thr?Gly?Arg

725 730 735

Lys?Gln?Leu?Leu?Lys?Leu?Ser?Ser?Leu?Tyr?Ala?Tyr?Ser?Glu?Leu?Phe

740 745 750

Ser?Ala?Leu?Tyr?Ser?Arg?Ile?Arg?Lys?Val?Asn?Leu?Asn?Leu?Pro?Val

755 760 765

Pro?Tyr?Glu?Pro?Pro?Arg?Arg?Lys?Ala?Ser?Leu?Met?Met?His

770 775 780

<210>76

<211>414

<212>PRT

＜213〉streptococcus pneumoniae

<400>76

Met?Met?Glu?Phe?Phe?Gln?Gln?Leu?Pro?His?Leu?Glu?Pro?Tyr?Gly?Asn

1 5 10 15

Pro?Gln?Tyr?Phe?Val?Tyr?Val?Ile?Ala?Ala?Thr?Leu?Pro?Ile?Phe?Ile

20 25 30

Gly?Leu?Phe?Phe?Lys?Lys?Arg?Phe?Ala?Trp?Tyr?Glu?Val?Leu?Val?Ser

35 40 45

Leu?Phe?Phe?Ile?Val?Thr?Met?Leu?Val?Gly?Gly?Lys?Thr?Asn?Gln?Leu

50 55 60

Ala?Ala?Leu?Gly?Ile?Tyr?Leu?Cys?Trp?Glu?Ile?Leu?Leu?Leu?Leu?Phe

65 70 75 80

Tyr?Lys?His?Tyr?Arg?Lys?Ser?Lys?Asp?Gly?Lys?Trp?Val?Phe?Tyr?Leu

85 90 95

Val?Ser?Phe?Leu?Ser?Leu?Leu?Pro?Ile?Ile?Phe?Val?Lys?Val?Gln?Pro

100 105 110

Ala?Ile?Asn?Gly?Thr?Gln?Ser?Leu?Leu?Gly?Phe?Leu?Gly?Ile?Ser?Tyr

115 120 125

Leu?Thr?Phe?Arg?Ser?Val?Gly?Ile?Val?Ile?Glu?Leu?Arg?Asp?Gly?Val

130 135 140

Ile?Lys?Asp?Phe?Thr?Leu?Trp?Glu?Phe?Leu?Arg?Phe?Leu?Leu?Phe?Met

145 150 155 160

Pro?Thr?Phe?Ser?Ser?Gly?Pro?Ile?Asp?Arg?Phe?Lys?Arg?Phe?Asn?Glu

165 170 175

Asn?Tyr?Gln?Ala?Ile?Pro?Glu?Arg?Asp?Glu?Leu?Met?Asp?Met?Leu?Asp

180 185 190

Glu?Ser?Val?Arg?Tyr?Ile?Met?Trp?Gly?Phe?Leu?Tyr?Lys?Phe?Ile?Leu

195 200 205

Ala?His?Val?Leu?Gly?Glu?Thr?Leu?Leu?Pro?Pro?Leu?Lys?Asn?Leu?Ala

210 215 220

Leu?Gln?Ser?Gly?Gly?Phe?Phe?Asn?Leu?Tyr?Ala?Leu?Ala?Val?Met?Tyr

225 230 235 240

Thr?Phe?Gly?Leu?Glu?Leu?Phe?Phe?Asp?Phe?Ala?Gly?Tyr?Ser?Met?Phe

245 250 255

Ala?Leu?Ala?Ile?Ser?Asn?Leu?Met?Gly?Ile?Arg?Ser?Pro?Ile?Asn?Phe

260 265 270

Asn?Lys?Pro?Phe?Leu?Ser?Arg?Asp?Leu?Lys?Glu?Phe?Trp?Asn?Arg?Trp

275 280 285

His?Met?Ser?Leu?Ser?Phe?Trp?Phe?Arg?Asp?Phe?Val?Phe?Met?Arg?Met

290 295 300

Val?Met?Val?Leu?Thr?Arg?Lys?Lys?Val?Phe?Lys?Asn?Arg?Asn?Val?Thr

305 310 315 320

Ser?Ser?Met?Ala?Tyr?Ile?Val?Asn?Met?Leu?Ile?Met?Gly?Phe?Trp?His

325 330 335

Gly?Val?Thr?Trp?Tyr?Tyr?Ile?Ala?Tyr?Gly?Leu?Phe?His?Gly?Leu?Gly

340 345 350

Leu?Val?Ile?Asn?Asp?Ala?Trp?Val?Arg?Lys?Lys?Lys?Thr?Leu?Asn?Lys

355 360 365

Glu?Arg?Lys?Lys?Ala?Gly?Lys?Ala?Ala?Leu?Pro?Glu?Asn?Arg?Trp?Ile

370 375 380

Gln?Leu?Leu?Gly?Met?Val?Val?Thr?Phe?His?Val?Val?Met?Leu?Ser?Phe

385 390 395 400

Leu?Ile?Phe?Ser?Gly?Phe?Leu?Asn?Asn?Leu?Trp?Phe?Lys?Lys

405 410

<210>77

<211>422

<212>PRT

＜213〉streptococcus pneumoniae

<400>77

Met?Leu?Lys?Arg?Leu?Trp?Met?Ile?Phe?Gly?Pro?Val?Leu?Ile?Ala?Gly

1 5 10 15

Leu?Leu?Val?Phe?Leu?Leu?Ile?Phe?Phe?Tyr?Pro?Thr?Glu?Met?His?His

20 25 30

Asn?Leu?Gly?Ala?Glu?Lys?Arg?Ser?Ala?Val?Ala?Thr?Thr?Ile?Asp?Ser

35 40 45

Phe?Lys?Glu?Arg?Ser?Gln?Lys?Val?Arg?Ala?Leu?Ser?Asp?Pro?Asn?Val

50 55 60

Arg?Phe?Val?Pro?Phe?Phe?Gly?Ser?Ser?Glu?Trp?Leu?Arg?Phe?Asp?Gly

65 70 75 80

Ala?His?Pro?Ala?Val?Leu?Ala?Glu?Lys?Tyr?Asn?Arg?Ser?Tyr?Arg?Pro

85 90 95

Tyr?Leu?Leu?Gly?Gln?Gly?Gly?Ala?Ala?Ser?Leu?Asn?Gln?Tyr?Phe?Gly

100 105 110

Met?Gln?Gln?Met?Leu?Pro?Gln?Leu?Glu?Asn?Lys?Gln?Val?Val?Tyr?Val

115 120 125

Ile?Ser?Pro?Gln?Trp?Phe?Ser?Lys?Asn?Gly?Tyr?Asp?Pro?Ala?Ala?Phe

130 135 140

Gln?Gln?Tyr?Phe?Asn?Gly?Asp?Gln?Leu?Thr?Ser?Phe?Leu?Lys?His?Gln

145 150 155 160

Ser?Gly?Asp?Gln?Ala?Ser?Gln?Tyr?Ala?Ala?Thr?Arg?Leu?Leu?Gln?Gln

165 170 175

Phe?Pro?Asn?Val?Ala?Met?Lys?Asp?Leu?Val?Gln?Lys?Leu?Ala?Ser?Lys

180 185 190

Glu?Glu?Leu?Ser?Thr?Ala?Asp?Asn?Glu?Met?Ile?Glu?Leu?Leu?Ala?Arg

195 200 205

Phe?Asn?Glu?Arg?Gln?Ala?Ser?Phe?Phe?Gly?Gln?Phe?Ser?Val?Arg?Gly

210 215 220

Tyr?Val?Asn?Tyr?Asp?Lys?His?Val?Ala?Lys?Tyr?Leu?Lys?Ile?Leu?Pro

225 230 235 240

Asp?Gln?Phe?Ser?Tyr?Gln?Ala?Ile?Glu?Asp?Val?Val?Lys?Ala?Asp?Ala

245 250 255

Glu?Lys?Asn?Thr?Ser?Asn?Asn?Glu?Met?Gly?Met?Glu?Asn?Tyr?Phe?Tyr

260 265 270

Asn?Glu?Gln?Ile?Lys?Lys?Asp?Leu?Lys?Lys?Leu?Lys?Asp?Ser?Gln?Lys

275 280 285

Ser?Phe?Thr?Tyr?Leu?Lys?Ser?Pro?Glu?Tyr?Asn?Asp?Leu?Gln?Leu?Val

290 295 300

Leu?Thr?Gln?Phe?Ser?Lys?Ser?Lys?Val?Asn?Pro?Ile?Phe?Ile?Ile?Pro

305 310 315 320

Pro?Val?Asn?Lys?Lys?Trp?Met?Asn?Tyr?Ala?Gly?Leu?Arg?Glu?Asp?Met

325 330 335

Tyr?Gln?Gln?Thr?Val?Gln?Lys?Ile?Arg?Tyr?Gln?Leu?Glu?Ser?Gln?Gly

340 345 350

Phe?Thr?Asn?Ile?Ala?Asp?Phe?Ser?Lys?Asp?Gly?Gly?Glu?Pro?Phe?Phe

355 360 365

Met?Lys?Asp?Thr?Ile?His?Leu?Gly?Trp?Leu?Gly?Trp?Leu?Ala?Phe?Asp

370 375 380

Lys?Ala?Val?Asp?Pro?Phe?Leu?Ser?Asn?Pro?Thr?Pro?Ala?Pro?Thr?Tyr

385 390 395 400

His?Leu?Asn?Glu?Arg?Phe?Phe?Ser?Lys?Asp?Trp?Ala?Thr?Tyr?Asp?Gly

405 410 415

Asp?Val?Lys?Glu?Phe?Gln

420

<210>78

<211>206

<212>PRT

＜213〉streptococcus pneumoniae

<400>78

Met?Glu?Lys?Asn?Leu?Lys?Ala?Leu?Lys?Gln?Thr?Thr?Asp?Gln?Glu?Gly

1 5 10 15

Pro?Ala?Ile?Glu?Pro?Glu?Lys?Ala?Glu?Asp?Thr?Lys?Thr?Val?Gln?Asn

20 25 30

Gly?Tyr?Phe?Glu?Asp?Ala?Ala?Val?Lys?Asp?Arg?Thr?Leu?Ser?Asp?Tyr

35 40 45

Ala?Gly?Asn?Trp?Gln?Ser?Val?Tyr?Pro?Phe?Leu?Glu?Asp?Gly?Thr?Phe

50 55 60

Asp?Gln?Val?Phe?Asp?Tyr?Lys?Ala?Lys?Leu?Thr?Gly?Lys?Met?Thr?Gln

65 70 75 80

Ala?Glu?Tyr?Lys?Ala?Tyr?Tyr?Thr?Lys?Gly?Tyr?His?Thr?Asp?Val?Thr

85 90 95

Lys?Ile?Asn?Ile?Thr?Asp?Asn?Thr?Met?Glu?Phe?Val?Gln?Gly?Gly?Gln

100 105 110

Ser?Lys?Lys?Tyr?Thr?Tyr?Lys?Tyr?Val?Gly?Lys?Lys?Ile?Leu?Thr?Tyr

115 120 125

Lys?Lys?Gly?Asn?Arg?Gly?Val?Arg?Phe?Leu?Phe?Glu?Ala?Thr?Asp?Ala

130 135 140

Asp?Ala?Gly?Gln?Phe?Lys?Tyr?Val?Gln?Phe?Ser?Asp?His?Asn?Val?Ala

145 150 155 160

Pro?Val?Lys?Ala?Glu?His?Phe?His?Ile?Phe?Phe?Gly?Gly?Thr?Ser?Gln

165 170 175

Glu?Ala?Leu?Phe?Glu?Glu?Met?Asp?Asn?Trp?Pro?Thr?Tyr?Tyr?Pro?Asp

180 185 190

Asn?Leu?Ser?Gly?Gln?Glu?Ile?Ala?Gln?Glu?Met?Leu?Ala?His

195 200 205

<210>79

<211>147

<212>PRT

＜213〉streptococcus pneumoniae

<400>79

Met?Lys?Asp?Gly?His?Leu?Leu?Ala?His?His?Ile?Arg?Leu?Leu?Asn?Gly

1 5 10 15

Arg?Ile?Phe?Gln?Lys?Leu?Leu?Ser?Gln?Asp?Pro?Glu?Ala?Leu?Tyr?Arg

20 25 30

Gly?Glu?Gln?Gly?Lys?Ile?Leu?Ala?Val?Leu?Trp?Asn?Ser?Glu?Thr?Gly

35 40 45

Cys?Ala?Thr?Ala?Thr?Asp?Ile?Ala?Leu?Ala?Thr?Gly?Leu?Ala?Asn?Asn

50 55 60

Thr?Leu?Thr?Thr?Met?Ile?Lys?Lys?Leu?Glu?Glu?Gln?Lys?Leu?Val?Ile

65 70 75 80

Val?Ser?Pro?Cys?Gly?Lys?Asp?Lys?Arg?Lys?Lys?Tyr?Leu?Val?Leu?Thr

85 90 95

Glu?Leu?Gly?Lys?Ser?Gln?Lys?Glu?Val?Gly?His?Arg?Val?Ser?Gln?Lys

100 105 110

Leu?Asp?Thr?Ile?Phe?Tyr?Lys?Gly?Phe?Ser?Glu?Glu?Glu?Ile?His?Gln

115 120 125

Phe?Glu?Gly?Phe?Gln?Glu?Arg?Ile?Leu?Ala?Asn?Leu?Lys?Glu?Lys?Gly

130 135 140

Asn?Glu?Val

145

<210>80

<211>506

<212>PRT

＜213〉streptococcus pneumoniae

<400>80

Met?Thr?Asn?Leu?Ile?Ala?Thr?Phe?Gln?Asp?Arg?Phe?Ser?Asp?Trp?Leu

1 5 10 15

Thr?Ala?Leu?Ser?Gln?His?Leu?Gln?Leu?Ser?Leu?Leu?Thr?Leu?Leu?Leu

20 25 30

Ala?Ile?Leu?Leu?Ala?Ile?Pro?Leu?Ala?Val?Phe?Leu?Arg?Tyr?His?Glu

35 40 45

Lys?Leu?Ala?Asp?Trp?Val?Leu?Gln?Ile?Ala?Gly?Ile?Phe?Gln?Thr?Ile

50 55 60

Pro?Ser?Leu?Ala?Leu?Leu?Gly?Leu?Phe?Ile?Pro?Leu?Met?Gly?Ile?Gly

65 70 75 80

Thr?Leu?Pro?Ala?Leu?Thr?Ala?Leu?Val?Ile?Tyr?Ala?Ile?Phe?Pro?Ile

85 90 95

Leu?Gln?Asn?Thr?Ile?Thr?Gly?Leu?Lys?Gly?Ile?Asp?Pro?Asn?Leu?Gln

100 105 110

Glu?Ala?Gly?Ile?Ala?Phe?Gly?Met?Thr?Arg?Trp?Glu?Arg?Leu?Lys?Lys

115 120 125

Phe?Glu?Ile?Pro?Leu?Ala?Met?Pro?Val?Ile?Met?Ser?Gly?Ile?Arg?Thr

130 135 140

Ala?Ala?Val?Leu?Ile?Ile?Gly?Thr?Ala?Thr?Leu?Ala?Ala?Leu?Ile?Gly

145 150 155 160

Ala?Gly?Gly?Leu?Gly?Ser?Phe?Ile?Leu?Leu?Gly?Ile?Asp?Arg?Asn?Asn

165 170 175

Ala?Ser?Leu?Ile?Leu?Ile?Gly?Ala?Leu?Ser?Ser?Ala?Val?Leu?Ala?Ile

180 185 190

Ala?Phe?Asn?Phe?Leu?Leu?Lys?Val?Met?Glu?Lys?Ala?Lys?Leu?Arg?Thr

195 200 205

Ile?Phe?Ser?Gly?Phe?Ala?Leu?Val?Ala?Leu?Leu?Leu?Gly?Leu?Ser?Tyr

210 215 220

Ser?Pro?Ala?Leu?Leu?Val?Gln?Lys?Glu?Lys?Glu?Asn?Leu?Val?Ile?Ala

225 230 235 240

Gly?Lys?Ile?Gly?Pro?Glu?Pro?Glu?Ile?Leu?Ala?Asn?Met?Tyr?Lys?Leu

245 250 255

Leu?Ile?Glu?Glu?Asn?Thr?Ser?Met?Thr?Ala?Thr?Val?Lys?Pro?Asn?Phe

260 265 270

Gly?Lys?Thr?Ser?Phe?Leu?Tyr?Glu?Ala?Leu?Lys?Lys?Gly?Asp?Ile?Asp

275 280 285

Ile?Tyr?Pro?Glu?Phe?Thr?Gly?Thr?Val?Thr?Glu?Ser?Leu?Leu?Gln?Pro

290 295 300

Ser?Pro?Lys?Val?Ser?His?Glu?Pro?Glu?Gln?Val?Tyr?Gln?Val?Ala?Arg

305 310 315 320

Asp?Gly?Ile?Ala?Lys?Gln?Asp?His?Leu?Ala?Tyr?Leu?Lys?Pro?Met?Ser

325 330 335

Tyr?Gln?Asn?Thr?Tyr?Ala?Val?Ala?Val?Pro?Lys?Lys?Ile?Ala?Gln?Glu

340 345 350

Tyr?Gly?Leu?Lys?Thr?Ile?Ser?Asp?Leu?Lys?Lys?Val?Glu?Gly?Gln?Leu

355 360 365

Lys?Ala?Gly?Phe?Thr?Leu?Glu?Phe?Asn?Asp?Arg?Glu?Asp?Gly?Asn?Lys

370 375 380

Gly?Leu?Gln?Ser?Met?Tyr?Gly?Leu?Asn?Leu?Asn?Val?Ala?Thr?Ile?Glu

385 390 395 400

Pro?Ala?Leu?Arg?Tyr?Gln?Ala?Ile?Gln?Ser?Gly?Asp?Ile?Gln?Ile?Thr

405 410 415

Asp?Ala?Tyr?Ser?Thr?Asp?Ala?Glu?Leu?Glu?Arg?Tyr?Asp?Leu?Gln?Val

420 425 430

Leu?Glu?Asp?Asp?Lys?Gln?Leu?Phe?Pro?Pro?Tyr?Gln?Gly?Ala?Pro?Leu

435 440 445

Met?Lys?Glu?Ala?Leu?Leu?Lys?Lys?His?Pro?Glu?Leu?Glu?Arg?Val?Leu

450 455 460

Asn?Thr?Leu?Ala?Gly?Lys?Ile?Thr?Glu?Ser?Gln?Met?Ser?Gln?Leu?Asn

465 470 475 480

Tyr?Gln?Val?Gly?Val?Glu?Gly?Lys?Ser?Ala?Lys?Gln?Val?Ala?Lys?Glu

485 490 495

Phe?Leu?Gln?Glu?Gln?Gly?Leu?Leu?Lys?Lys

500 505

<210>81

<211>269

<212>PRT

＜213〉streptococcus pneumoniae

<400>81

Met?Met?His?Thr?Tyr?Leu?Gln?Lys?Lys?Ile?Glu?Asn?Ile?Lys?Thr?Thr

1 5 10 15

Leu?Gly?Glu?Met?Ser?Gly?Gly?Tyr?Arg?Arg?Met?Val?Ala?Ala?Met?Ala

20 25 30

Asp?Leu?Gly?Phe?Ser?Gly?Thr?Met?Lys?Ala?Ile?Trp?Asp?Asp?Leu?Phe

35 40 45

Ala?His?Arg?Ser?Phe?Ala?Gln?Trp?Ile?Tyr?Leu?Leu?Val?Leu?Gly?Ser

50 55 60

Phe?Pro?Leu?Trp?Leu?Glu?Leu?Val?Tyr?Glu?His?Arg?Ile?Val?Asp?Trp

65 70 75 80

Ile?Gly?Met?Ile?Cys?Ser?Leu?Thr?Gly?Ile?Ile?Cys?Val?Ile?Phe?Val

85 90 95

Ser?Glu?Gly?Arg?Ala?Ser?Asn?Tyr?Leu?Phe?Gly?Leu?Ile?Asn?Ser?Val

100 105 110

Ile?Tyr?Leu?Ile?Leu?Ala?Leu?Gln?Lys?Gly?Phe?Tyr?Gly?Glu?Val?Leu

115 120 125

Thr?Thr?Leu?Tyr?Phe?Thr?Val?Met?Gln?Pro?Ile?Gly?Leu?Leu?Val?Trp

130 135 140

Ile?Tyr?Gln?Ala?Gln?Phe?Lys?Lys?Glu?Lys?Gln?Glu?Phe?Val?Ala?Arg

145 150 155 160

Lys?Leu?Asp?Gly?Lys?Gly?Trp?Thr?Lys?Tyr?Leu?Ser?Ile?Ser?Val?Leu

165 170 175

Trp?Trp?Leu?Ala?Phe?Gly?Phe?Ile?Tyr?Gln?Ser?Ile?Gly?Ala?Asn?Arg

180 185 190

Pro?Tyr?Arg?Asp?Ser?Ile?Thr?Asp?Ala?Thr?Asn?Gly?Val?Gly?Gln?Ile

195 200 205

Leu?Met?Thr?Ala?Val?Tyr?Arg?Glu?Gln?Trp?Ile?Phe?Trp?Ala?Ala?Thr

210 215 220

Asn?Val?Phe?Ser?Ile?Tyr?Leu?Trp?Trp?Gly?Glu?Ser?Leu?Gln?Ile?Gln

225 230 235 240

Gly?Lys?Tyr?Leu?Ile?Tyr?Leu?Ile?Asn?Ser?Leu?Val?Gly?Trp?Tyr?Gln

245 250 255

Trp?Ser?Lys?Ala?Ala?Lys?Gln?Asn?Thr?Asp?Leu?Leu?Asn

260 265

<210>82

<211>299

<212>PRT

＜213〉streptococcus pneumoniae

<400>82

Met?Arg?Asn?Met?Lys?Ala?Lys?Tyr?Ala?Val?Trp?Val?Ala?Phe?Phe?Leu

1 5 10 15

Asn?Leu?Thr?Tyr?Ala?Ile?Val?Glu?Phe?Ile?Ala?Gly?Gly?Val?Phe?Gly

20 25 30

Ser?Ser?Ala?Val?Leu?Ala?Asp?Ser?Val?His?Asp?Leu?Gly?Asp?Ala?Ile

35 40 45

Ala?Ile?Gly?Ile?Ser?Ala?Phe?Leu?Glu?Thr?Ile?Ser?Asn?Arg?Glu?Glu

50 55 60

Asp?Asn?Gln?Tyr?Thr?Leu?Gly?Tyr?Lys?Arg?Phe?Ser?Leu?Leu?Gly?Ala

65 70 75 80

Leu?Val?Thr?Ala?Val?Ile?Leu?Val?Thr?Gly?Ser?Val?Leu?Val?Ile?Leu

85 90 95

Glu?Asn?Val?Thr?Lys?Ile?Leu?His?Pro?Gln?Pro?Val?Asn?Asp?Glu?Gly

100 105 110

Ile?Leu?Trp?Leu?Gly?Ile?Ile?Ala?Ile?Thr?Ile?Asn?Leu?Leu?Ala?Ser

115 120 125

Leu?Val?Val?Gly?Lys?Gly?Lys?Thr?Lys?Asn?Glu?Ser?Ile?Leu?Ser?Leu

130 135 140

His?Phe?Leu?Glu?Asp?Thr?Leu?Gly?Trp?Val?Ala?Val?Ile?Leu?Met?Ala

145 150 155 160

Ile?Val?Leu?Arg?Phe?Thr?Asp?Trp?Tyr?Ile?Leu?Asp?Pro?Leu?Leu?Ser

165 170 175

Leu?Val?Ile?Ser?Phe?Phe?Ile?Leu?Ser?Lys?Ala?Leu?Pro?Arg?Phe?Trp

180 185 190

Ser?Thr?Leu?Lys?Ile?Phe?Leu?Asp?Ala?Val?Pro?Glu?Gly?Leu?Asp?Ile

195 200 205

Lys?Gln?Val?Lys?Ser?Gly?Leu?Glu?Arg?Leu?Asp?Asn?Val?Ala?Ser?Leu

210 215 220

Asn?Gln?Leu?Asn?Leu?Trp?Thr?Met?Asp?Ala?Leu?Glu?Lys?Asn?Ala?Ile

225 230 235 240

Val?His?Val?Cys?Leu?Lys?Glu?Met?Glu?His?Met?Glu?Thr?Cys?Lys?Glu

245 250 255

Ser?Ile?Arg?Ile?Phe?Leu?Lys?Asp?Cys?Gly?Phe?Gln?Asn?Ile?Thr?Ile

260 265 270

Glu?Ile?Asp?Ala?Asp?Leu?Glu?Thr?His?Gln?Thr?His?Lys?Arg?Lys?Val

275 280 285

Cys?Asp?Leu?Glu?Arg?Ser?Tyr?Glu?His?Gln?His

290 295

<210>83

<211>242

<212>PRT

＜213〉streptococcus pneumoniae

<400>83

Met?Ile?Glu?Tyr?Lys?Asn?Val?Ala?Leu?Arg?Tyr?Thr?Glu?Lys?Asp?Val

1 5 10 15

Leu?Arg?Asp?Val?Asn?Leu?Gln?Ile?Glu?Asp?Gly?Glu?Phe?Met?Val?Leu

20 25 30

Val?Gly?Pro?Ser?Gly?Ser?Gly?Lys?Thr?Thr?Met?Leu?Lys?Met?Ile?Asn

35 40 45

Arg?Leu?Leu?Glu?Pro?Thr?Asp?Gly?Asn?Ile?Tyr?Met?Asp?Gly?Lys?Arg

50 55 60

Ile?Lys?Asp?Tyr?Asp?Glu?Arg?Glu?Leu?Arg?Leu?Ser?Thr?Gly?Tyr?Val

65 70 75 80

Leu?Gln?Ala?Ile?Ala?Leu?Phe?Pro?Asn?Leu?Thr?Val?Ala?Glu?Asn?Ile

85 90 95

Ala?Leu?Ile?Pro?Glu?Met?Lys?Gly?Trp?Ser?Lys?Glu?Glu?Ile?Thr?Lys

100 105 110

Lys?Thr?Glu?Glu?Leu?Leu?Ala?Lys?Val?Gly?Leu?Pro?Val?Ala?Glu?Tyr

115 120 125

Gly?His?Arg?Leu?Pro?Ser?Glu?Leu?Ser?Gly?Gly?Glu?Gln?Gln?Arg?Val

130 135 140

Gly?Ile?Val?Arg?Ala?Met?Ile?Gly?Gln?Pro?Lys?Ile?Phe?Leu?Met?Asp

145 150 155 160

Glu?Pro?Phe?Ser?Ala?Leu?Asp?Ala?Ile?Ser?Arg?Lys?Gln?Leu?Gln?Val

165 170 175

Leu?Thr?Lys?Glu?Leu?His?Lys?Glu?Phe?Gly?Met?Thr?Thr?Ile?Phe?Val

180 185 190

Thr?His?Asp?Thr?Asp?Glu?Ala?Leu?Lys?Leu?Ala?Asp?Arg?Ile?Ala?Val

195 200 205

Leu?Gln?Asp?Gly?Glu?Ile?Arg?Gln?Val?Ala?Asn?Pro?Glu?Thr?Ile?Leu

210 215 220

Lys?Ala?Pro?Ala?Thr?Asp?Phe?Val?Ala?Asp?Leu?Phe?Gly?Gly?Ser?Val

225 230 235 240

His?Asp

<210>84

<211>360

<212>PRT

＜213〉streptococcus pneumoniae

<400>84

Met?Ser?Ala?Val?Ala?Ile?Ser?Ala?Met?Thr?Lys?Val?Met?Gln?Glu?Thr

1 5 10 15

His?Gly?Asn?Pro?Ser?Ser?Ile?His?Gly?His?Gly?Arg?Gln?Ala?Gly?Lys

20 25 30

Leu?Leu?Arg?Glu?Ala?Arg?Gln?Glu?Leu?Ala?Gln?Leu?Leu?Arg?Thr?Lys

35 40 45

Pro?Gln?His?Ile?Phe?Phe?Thr?Ser?Gly?Gly?Thr?Glu?Gly?Asn?Asn?Thr

50 55 60

Thr?Ile?Ile?Gly?Tyr?Cys?Leu?Arg?His?Gln?Glu?Gln?Gly?Lys?His?Ile

65 70 75 80

Ile?Thr?Thr?Ala?Ile?Glu?His?His?Ala?Val?Leu?Glu?Thr?Ile?Asp?Tyr

85 90 95

Leu?Val?Gln?His?Phe?Gly?Phe?Glu?Ala?Thr?Ile?Ile?Gln?Pro?Glu?Asn

100 105 110

Gln?Glu?Ile?Thr?Ala?Gln?Gln?Ile?Gln?Lys?Ala?Leu?Arg?Asp?Asp?Thr

115 120 125

Ile?Leu?Val?Ser?Thr?Met?Phe?Val?Asn?Asn?Glu?Thr?Gly?Asn?Leu?Leu

130 135 140

Pro?Ile?Ala?Glu?Ile?Gly?Gln?Ile?Leu?Lys?Gln?His?Pro?Ala?Ala?Tyr

145 150 155 160

His?Val?Asp?Ala?Val?Gln?Ala?Ile?Gly?Lys?Ile?Pro?Ile?His?Ser?Glu

165 170 175

Glu?Leu?Gly?Ile?Asp?Phe?Leu?Thr?Ala?Ser?Ala?His?Lys?Phe?His?Gly

180 185 190

Pro?Lys?Gly?Ile?Gly?Phe?Leu?Tyr?Ala?Ser?Ser?Met?Asp?Phe?Asp?Ser

195 200 205

Tyr?Leu?His?Gly?Gly?Asp?Gln?Glu?Gln?Lys?Lys?Arg?Ala?Gly?Thr?Glu

210 215 220

Asn?Leu?Pro?Ala?Ile?Val?Gly?Met?Val?Ala?Ala?Leu?Lys?Glu?Asp?Leu

225 230 235 240

Glu?Lys?Gln?Glu?Glu?His?Phe?Gln?His?Val?Gln?Asn?Leu?Glu?Thr?Ala

245 250 255

Phe?Leu?Ala?Glu?Leu?Glu?Gly?Ile?Gln?Tyr?Tyr?Leu?Asn?Arg?Gly?Lys

260 265 270

His?His?Leu?Pro?Tyr?Val?Leu?Asn?Ile?Gly?Phe?Pro?Gly?Gln?Lys?Asn

275 280 285

Asp?Leu?Leu?Leu?Leu?Arg?Leu?Asp?Leu?Ala?Gly?Ile?Ser?Ile?Ser?Thr

290 295 300

Gly?Ser?Ala?Cys?Thr?Ala?Gly?Val?Val?Gln?Ser?Ser?His?Val?Leu?Glu

305 310 315 320

Ala?Met?Tyr?Gly?Ala?Asn?Ser?Glu?Arg?Leu?Lys?Glu?Ser?Leu?Arg?Ile

325 330 335

Ser?Leu?Ser?Pro?Gln?Asn?Thr?Val?Glu?Asp?Leu?Gln?Thr?Leu?Ala?Lys

340 345 350

Thr?Leu?Lys?Glu?Ile?Ile?Gly?Gly

355 360

<210>85

<211>459

<212>PRT

＜213〉streptococcus pneumoniae

<400>85

Met?Leu?Phe?Lys?Leu?Ser?Lys?Glu?Lys?Ile?Glu?Leu?Gly?Leu?Ser?Arg

1 5 10 15

Leu?Ser?Pro?Ala?Arg?Arg?Ile?Phe?Leu?Ser?Phe?Ala?Leu?Val?Ile?Leu

20 25 30

Leu?Gly?Ser?Leu?Leu?Leu?Ser?Leu?Pro?Phe?Val?Gln?Val?Glu?Ser?Ser

35 40 45

Arg?Ala?Thr?Tyr?Phe?Asp?His?Leu?Phe?Thr?Ala?Val?Ser?Ala?Val?Cys

50 55 60

Val?Thr?Gly?Leu?Ser?Thr?Leu?Pro?Val?Ala?His?Thr?Tyr?Asn?Ile?Trp

65 70 75 80

Gly?Gln?Ile?Ile?Cys?Leu?Leu?Leu?Ile?Gln?Ile?Gly?Gly?Leu?Gly?Leu

85 90 95

Met?Thr?Phe?Ile?Gly?Val?Phe?Tyr?Ile?Gln?Ser?Lys?Gln?Lys?Leu?Ser

100 105 110

Leu?Arg?Ser?Arg?Ala?Thr?Ile?Gln?Asp?Ser?Phe?Ser?Tyr?Gly?Glu?Thr

115 120 125

Arg?Ser?Leu?Arg?Lys?Phe?Val?Tyr?Ser?Ile?Phe?Leu?Thr?Thr?Phe?Leu

130 135 140

Val?Glu?Ser?Leu?Gly?Ala?Ile?Leu?Leu?Ser?Phe?Arg?Leu?Ile?Pro?Gln

145 150 155 160

Leu?Gly?Trp?Gly?Arg?Gly?Leu?Phe?Ser?Ser?Ile?Phe?Leu?Ala?Ile?Ser

165 170 175

Ala?Phe?Cys?Asn?Ala?Gly?Phe?Asp?Asn?Leu?Gly?Ser?Thr?Ser?Leu?Phe

180 185 190

Ala?Phe?Gln?Thr?Asp?Leu?Leu?Val?Asn?Leu?Val?Ile?Ala?Gly?Leu?Ile

195 200 205

Ile?Thr?Gly?Gly?Leu?Gly?Phe?Met?Val?Trp?Phe?Asp?Leu?Ala?Gly?His

210 215 220

Val?Gly?Arg?Lys?Lys?Lys?Gly?Arg?Leu?His?Phe?His?Thr?Lys?Leu?Val

225 230 235 240

Leu?Leu?Leu?Thr?Ile?Gly?Leu?Leu?Leu?Phe?Gly?Thr?Ala?Thr?Thr?Leu

245 250 255

Phe?Leu?Glu?Trp?Asn?Asn?Ala?Gly?Thr?Ile?Gly?Asn?Leu?Pro?Val?Ala

260 265 270

Asp?Lys?Val?Leu?Val?Ser?Phe?Phe?Gln?Thr?Val?Thr?Met?Arg?Thr?Ala

275 280 285

Gly?Phe?Ser?Thr?Ile?Asp?Tyr?Thr?Gln?Ala?His?Pro?Val?Thr?Leu?Leu

290 295 300

Ile?Tyr?Ile?Leu?Gln?Met?Phe?Leu?Gly?Gly?Ala?Pro?Gly?Gly?Thr?Ala

305 310 315 320

Gly?Gly?Leu?Lys?Ile?Thr?Thr?Phe?Phe?Val?Leu?Leu?Val?Phe?Ala?Arg

325 330 335

Ser?Glu?Leu?Leu?Gly?Leu?Pro?His?Ala?Asn?Val?Ala?Arg?Arg?Thr?Ile

340 345 350

Ala?Pro?Arg?Thr?Val?Gln?Lys?Ser?Phe?Ser?Val?Phe?Ile?Ile?Phe?Leu

355 360 365

Met?Ser?Phe?Leu?Ile?Gly?Leu?Ile?Leu?Leu?Gly?Ile?Thr?Ala?Lys?Gly

370 375 380

Asn?Pro?Pro?Phe?Ile?His?Leu?Val?Phe?Glu?Thr?Ile?Ser?Ala?Leu?Ser

385 390 395 400

Thr?Val?Gly?Val?Thr?Ala?Asn?Leu?Thr?Pro?Asp?Leu?Gly?Lys?Leu?Ala

405 410 415

Leu?Ser?Val?Ile?Met?Pro?Leu?Met?Phe?Met?Gly?Arg?Ile?Gly?Pro?Leu

420 425 430

Thr?Leu?Phe?Val?Ser?Leu?Ala?Asp?Tyr?His?Pro?Glu?Lys?Lys?Asp?Met

435 440 445

Ile?His?Tyr?Met?Lys?Ala?Asp?Ile?Ser?Ile?Gly

450 455

<210>86

<211>221

<212>PRT

＜213〉streptococcus pneumoniae

<400>86

Met?Ser?Asp?Arg?Thr?Ile?Gly?Ile?Leu?Gly?Leu?Gly?Ile?Phe?Gly?Ser

1 5 10 15

Ser?Val?Leu?Ala?Ala?Leu?Ala?Lys?Gln?Asp?Met?Asn?Ile?Ile?Ala?Ile

20 25 30

Asp?Asp?His?Ala?Glu?Arg?Ile?Asn?Gln?Phe?Glu?Pro?Val?Leu?Ala?Arg

35 40 45

Gly?Val?Ile?Gly?Asp?Ile?Thr?Asp?Glu?Glu?Leu?Leu?Arg?Ser?Ala?Gly

50 55 60

Ile?Asp?Thr?Cys?Asp?Thr?Val?Val?Val?Ala?Thr?Gly?Glu?Asn?Leu?Glu

65 70 75 80

Ser?Ser?Val?Leu?Ala?Val?Met?His?Cys?Lys?Ser?Leu?Gly?Val?Pro?Thr

85 90 95

Val?Ile?Ala?Lys?Val?Lys?Ser?Gln?Thr?Ala?Lys?Lys?Val?Leu?Glu?Lys

100 105 110

Ile?Gly?Ala?Asp?Ser?Val?Ile?Ser?Pro?Glu?Tyr?Glu?Met?Gly?Gln?Ser

115 120 125

Leu?Ala?Gln?Thr?Ile?Leu?Phe?His?Asn?Ser?Val?Asp?Val?Phe?Gln?Leu

130 135 140

Asp?Lys?Asn?Val?Ser?Ile?Val?Glu?Met?Lys?Ile?Pro?Gln?Ser?Trp?Ala

145 150 155 160

Gly?Gln?Ser?Leu?Ser?Lys?Leu?Asp?Leu?Arg?Gly?Lys?Tyr?Asn?Leu?Asn

165 170 175

Ile?Leu?Gly?Phe?Arg?Glu?Gln?Glu?Asn?Ser?Pro?Leu?Asp?Val?Glu?Phe

180 185 190

Gly?Pro?Asp?Asp?Leu?Leu?Lys?Ala?Asp?Thr?Tyr?Ile?Leu?Ala?Val?Ile

195 200 205

Asn?Asn?Gln?Tyr?Leu?Asp?Thr?Leu?Val?Ala?Leu?Asn?Ser

210 215 220

<210>87

<211>179

<212>PRT

＜213〉streptococcus pneumoniae

<400>87

Met?Lys?Leu?Leu?Ser?Ile?Ala?Ile?Ser?Ser?Tyr?Asn?Ala?Ala?Ala?Tyr

1 5 10 15

Leu?His?Tyr?Cys?Val?Glu?Ser?Leu?Val?Ile?Gly?Gly?Glu?Gln?Val?Gly

20 25 30

Ile?Leu?Ile?Ile?Asn?Asp?Gly?Ser?Gln?Asp?Gln?Thr?Gln?Glu?Ile?Ala

35 40 45

Glu?Cys?Leu?Ala?Ser?Lys?Tyr?Pro?Asn?Ile?Val?Arg?Ala?Ile?Tyr?Gln

50 55 60

Glu?Asn?Lys?Cys?His?Gly?Gly?Ala?Val?Asn?Arg?Gly?Leu?Val?Glu?Ala

65 70 75 80

Ser?Gly?Arg?Tyr?Phe?Lys?Val?Val?Asp?Ser?Asp?Asp?Trp?Val?Asp?Pro

85 90 95

Arg?Ala?Tyr?Leu?Lys?Ile?Leu?Glu?Thr?Leu?Gln?Glu?Leu?Glu?Ser?Lys

100 105 110

Gly?Gln?Glu?Val?Asp?Val?Phe?Val?Thr?Asn?Phe?Val?Tyr?Glu?Lys?Glu

115 120 125

Gly?Gln?Ser?Arg?Lys?Lys?Ser?Met?Ser?Tyr?Asp?Ser?Val?Leu?Pro?Val

130 135 140

Arg?Gln?Ile?Phe?Gly?Trp?Asp?Gln?Val?Gly?Asn?Phe?Ser?Lys?Gly?Gln

145 150 155 160

Tyr?Thr?Met?Met?His?Ser?Leu?Ile?Tyr?Arg?Thr?Asp?Leu?Leu?Arg?Ala

165 170 175

Ser?Gln?Phe

<210>88

<211>623

<212>PRT

＜213〉streptococcus pneumoniae

<400>88

Met?Lys?Phe?Asn?Pro?Asn?Gln?Arg?Tyr?Thr?Arg?Trp?Ser?Ile?Arg?Arg

1 5 10 15

Leu?Ser?Val?Gly?Val?Ala?Ser?Val?Val?Val?Ala?Ser?Gly?Phe?Phe?Val

20 25 30

Leu?Val?Gly?Gln?Pro?Ser?Ser?Val?Arg?Ala?Asp?Gly?Leu?Asn?Pro?Thr

35 40 45

Pro?Gly?Gln?Val?Leu?Pro?Glu?Glu?Thr?Ser?Gly?Thr?Lys?Glu?Gly?Asp

50 55 60

Leu?Ser?Glu?Lys?Pro?Gly?Asp?Thr?Val?Leu?Thr?Gln?Ala?Lys?Pro?Glu

65 70 75 80

Gly?Val?Thr?Gly?Asn?Thr?Asn?Ser?Leu?Pro?Thr?Pro?Thr?Glu?Arg?Thr

85 90 95

Glu?Val?Ser?Glu?Glu?Thr?Ser?Pro?Ser?Ser?Leu?Asp?Thr?Leu?Phe?Glu

100 105 110

Lys?Asp?Glu?Glu?Ala?Gln?Lys?Asn?Pro?Glu?Leu?Thr?Asp?Val?Leu?Lys

115 120 125

Glu?Thr?Val?Asp?Thr?Ala?Asp?Val?Asp?Gly?Thr?Gln?Ala?Ser?Pro?Ala

130 135 140

Glu?Thr?Thr?Pro?Glu?Gln?Val?Lys?Gly?Gly?Val?Lys?Glu?Asn?Thr?Lys

145 150 155 160

Asp?Ser?Ile?Asp?Val?Pro?Ala?Ala?Tyr?Leu?Glu?Lys?Ala?Glu?Gly?Lys

165 170 175

Gly?Pro?Phe?Thr?Ala?Gly?Val?Asn?Gln?Val?Ile?Pro?Tyr?Glu?Leu?Phe

180 185 190

Ala?Gly?Asp?Gly?Met?Leu?Thr?Arg?Leu?Leu?Leu?Lys?Ala?Ser?Asp?Asn

195 200 205

Ala?Pro?Trp?Ser?Asp?Asn?Gly?Thr?Ala?Lys?Asn?Pro?Ala?Leu?Pro?Pro

210 215 220

Leu?Glu?Gly?Leu?Thr?Lys?Gly?Lys?Tyr?Phe?Tyr?Glu?Val?Asp?Leu?Asn

225 230 235 240

Gly?Asn?Thr?Val?Gly?Lys?Gln?Gly?Gln?Ala?Leu?Ile?Asp?Gln?Leu?Arg

245 250 255

Ala?Asn?Gly?Thr?Gln?Thr?Tyr?Lys?Ala?Thr?Val?Lys?Val?Tyr?Gly?Asn

260 265 270

Lys?Asp?Gly?Lys?Ala?Asp?Leu?Thr?Asn?Leu?Val?Ala?Thr?Lys?Asn?Val

275 280 285

Asp?Ile?Asn?Ile?Asn?Gly?Leu?Val?Ala?Lys?Glu?Thr?Val?Gln?Lys?Ala

290 295 300

Val?Ala?Asp?Asn?Val?Lys?Asp?Ser?Ile?Asp?Val?Pro?Ala?Ala?Tyr?Leu

305 310 315 320

Glu?Lys?Ala?Lys?Gly?Glu?Gly?Pro?Phe?Thr?Ala?Gly?Val?Asn?His?Val

325 330 335

Ile?Pro?Tyr?Glu?Leu?Phe?Ala?Gly?Asp?Gly?Met?Leu?Thr?Arg?Leu?Leu

340 345 350

Leu?Lys?Ala?Ser?Asp?Lys?Ala?Pro?Trp?Ser?Asp?Asn?Gly?Asp?Ala?Lys

355 360 365

Asn?Pro?Ala?Leu?Ser?Pro?Leu?Gly?Glu?Asn?Val?Lys?Thr?Lys?Gly?Gln

370 375 380

Tyr?Phe?Tyr?Gln?Val?Ala?Leu?Asp?Gly?Asn?Val?Ala?Gly?Lys?Glu?Lys

385 390 395 400

Gln?Ala?Leu?Ile?Asp?Gln?Phe?Arg?Ala?Asn?Gly?Thr?Gln?Thr?Tyr?Ser

405 410 415

Ala?Thr?Val?Asn?Val?Tyr?Gly?Asn?Lys?Asp?Gly?Lys?Pro?Asp?Leu?Asp

420 425 430

Asn?Ile?Val?Ala?Thr?Lys?Lys?Val?Thr?Ile?Asn?Ile?Asn?Gly?Leu?Ile

435 440 445

Ser?Lys?Glu?Thr?Val?Gln?Lys?Ala?Val?Ala?Asp?Asn?Val?Lys?Asp?Ser

450 455 460

Ile?Asp?Val?Pro?Ala?Ala?Tyr?Leu?Glu?Lys?Ala?Lys?Gly?Glu?Gly?Pro

465 470 475 480

Phe?Thr?Ala?Gly?Val?Asn?His?Val?Ile?Pro?Tyr?Glu?Leu?Phe?Ala?Gly

485 490 495

Asp?Gly?Met?Leu?Thr?Arg?Leu?Leu?Leu?Lys?Ala?Ser?Asp?Lys?Ala?Pro

500 505 510

Trp?Ser?Asp?Asn?Gly?Asp?Ala?Lys?Asn?Pro?Ala?Leu?Ser?Pro?Leu?Gly

515 520 525

Glu?Asn?Val?Lys?Thr?Lys?Gly?Gln?Tyr?Phe?Tyr?Gln?Leu?Ala?Leu?Asp

530 535 540

Gly?Asn?Val?Ala?Gly?Lys?Glu?Lys?Gln?Ala?Leu?Ile?Asp?Gln?Phe?Arg

545 550 555 560

Ala?Asn?Gly?Thr?Gln?Thr?Tyr?Ser?Ala?Thr?Val?Asn?Val?Tyr?Gly?Asn

565 570 575

Lys?Asp?Gly?Lys?Pro?Asp?Leu?Asp?Asn?Ile?Val?Ala?Thr?Lys?Lys?Val

580 585 590

Thr?Ile?Asn?Ile?Asn?Gly?Leu?Ile?Ser?Lys?Glu?Thr?Val?Gln?Lys?Ala

595 600 605

Val?Ala?Asp?Asn?Val?Lys?Thr?Val?Ser?Met?Phe?Gln?Gln?Pro?Thr

610 615 620

<210>89

<211>350

<212>PRT

＜213〉streptococcus pneumoniae

<400>89

Met?Lys?Leu?Lys?Ser?Tyr?Ile?Leu?Val?Gly?Tyr?Ile?Ile?Ser?Thr?Leu

1 5 10 15

Leu?Thr?Ile?Leu?Val?Val?Phe?Trp?Ala?Val?Gln?Lys?Met?Leu?Ile?Ala

20 25 30

Lys?Gly?Glu?Ile?Tyr?Phe?Leu?Leu?Gly?Met?Thr?Ile?Val?Ala?Ser?Leu

35 40 45

Val?Gly?Ala?Gly?Ile?Ser?Leu?Phe?Leu?Leu?Leu?Pro?Val?Phe?Thr?Ser

50 55 60

Leu?Gly?Lys?Leu?Lys?Glu?His?Ala?Lys?Arg?Val?Ala?Ala?Lys?Asp?Phe

65 70 75 80

Pro?Ser?Asn?Leu?Glu?Val?Gln?Gly?Pro?Val?Glu?Phe?Gln?Gln?Leu?Gly

85 90 95

Gln?Thr?Phe?Asn?Glu?Met?Ser?His?Asp?Leu?Gln?Val?Ser?Phe?Asp?Ser

100 105 110

Leu?Glu?Glu?Ser?Glu?Arg?Glu?Lys?Gly?Leu?Met?Ile?Ala?Gln?Leu?Ser

115 120 125

His?Asp?Ile?Lys?Thr?Pro?Ile?Thr?Ser?Ile?Gln?Ala?Thr?Val?Glu?Gly

130 135 140

Ile?Leu?Asp?Gly?Ile?Ile?Lys?Glu?Ser?Glu?Gln?Ala?His?Tyr?Leu?Ala

145 150 155 160

Thr?Ile?Gly?Arg?Gln?Thr?Glu?Arg?Leu?Asn?Lys?Leu?Val?Glu?Glu?Leu

165 170 175

Asn?Phe?Leu?Thr?Leu?Asn?Thr?Ala?Arg?Asn?Gln?Val?Glu?Thr?Thr?Ser

180 185 190

Lys?Asp?Ser?Ile?Phe?Leu?Asp?Lys?Leu?Leu?Ile?Glu?Cys?Met?Ser?Glu

195 200 205

Phe?Gln?Phe?Leu?Ile?Glu?Gln?Glu?Arg?Arg?Asp?Val?His?Leu?Gln?Val

210 215 220

Ile?Pro?Glu?Ser?Ala?Arg?Ile?Glu?Gly?Asp?Tyr?Ala?Lys?Leu?Ser?Arg

225 230 235 240

Ile?Leu?Val?Asn?Leu?Val?Asp?Asn?Ala?Phe?Lys?Tyr?Ser?Ala?Pro?Gly

245 250 255

Thr?Lys?Leu?Glu?Val?Val?Ala?Lys?Leu?Glu?Lys?Asp?Gln?Leu?Ser?Ile

260 265 270

Ser?Val?Thr?Asp?Glu?Gly?Gln?Gly?Ile?Ala?Pro?Glu?Asp?Leu?Glu?Asn

275 280 285

Ile?Phe?Lys?Arg?Leu?Tyr?Arg?Val?Glu?Thr?Ser?Arg?Asn?Met?Lys?Thr

290 295 300

Gly?Gly?His?Gly?Leu?Gly?Leu?Ala?Ile?Ala?Arg?Glu?Leu?Ala?His?Gln

305 310 315 320

Leu?Gly?Gly?Glu?Ile?Thr?Val?Ser?Ser?Gln?Tyr?Gly?Leu?Gly?Ser?Thr

325 330 335

Phe?Thr?Leu?Val?Leu?Asn?Leu?Ser?Gly?Ser?Glu?Asn?Lys?Ala

340 345 350

<210>90

<211>175

<212>PRT

＜213〉streptococcus pneumoniae

<400>90

Met?Phe?Gly?Gln?Thr?Ala?Gln?His?Gly?Leu?Thr?Asn?Ser?Leu?Lys?Asp

1 5 10 15

Phe?Trp?Ile?Phe?Leu?Leu?Asn?Ile?Gly?Pro?Gln?Leu?Ala?Phe?Phe?Cys

20 25 30

Gln?Met?Leu?Arg?Cys?Ser?Arg?Ser?Val?Glu?Gln?Gly?Thr?Gly?Asn?His

35 40 45

Arg?Arg?Glu?Phe?Asn?Met?Ile?Gln?Gln?Ile?Phe?Ser?His?Phe?Gly?Met

50 55 60

Thr?His?Leu?Gly?Gln?Ile?Lys?Leu?Val?Tyr?Gln?Glu?Ser?Ile?Asp?Leu

65 70 75 80

Glu?Leu?Leu?Val?Asn?Ala?Leu?Asn?His?His?Leu?Leu?Ile?Asp?Arg?Leu

85 90 95

Val?Leu?Thr?Pro?Asn?Gln?Ile?Thr?Ile?Glu?Ile?Asp?Arg?Gln?Ile?Val

100 105 110

His?Gly?Leu?Asp?Leu?Leu?Lys?Gly?Arg?Lys?Asp?Lys?Glu?Ile?Ile?Asp

115 120 125

Ile?Lys?Ser?Met?Phe?Arg?Gln?Leu?Glu?Leu?Ala?Ser?Thr?Gln?Gln?Ile

130 135 140

Cys?Pro?Ile?Asn?Gln?Arg?Val?His?His?Gly?Ile?Leu?Ala?Phe?Gly?Glu

145 150 155 160

Ile?Ser?Asp?Leu?Val?Pro?Ala?Lys?Asn?Leu?Pro?Asn?Arg?Gln?Asp

165 170 175

<210>91

<211>158

<212>PRT

＜213〉streptococcus pneumoniae

<400>91

Met?Glu?His?Leu?Ala?Thr?Tyr?Phe?Ser?Thr?Tyr?Gly?Gly?Ala?Phe?Phe

1 5 10 15

Ala?Ala?Leu?Gly?Ile?Val?Leu?Ala?Val?Gly?Leu?Ser?Gly?Met?Gly?Ser

20 25 30

Ala?Tyr?Gly?Val?Gly?Lys?Ala?Gly?Gln?Ser?Ala?Ala?Ala?Leu?Leu?Lys

35 40 45

Glu?Gln?Pro?Glu?Lys?Phe?Ala?Ser?Ala?Leu?Ile?Leu?Gln?Leu?Leu?Pro

50 55 60

Gly?Thr?Gln?Gly?Leu?Tyr?Gly?Phe?Val?Ile?Gly?Ile?Leu?Ile?Trp?Leu

65 70 75 80

Gln?Leu?Thr?Pro?Glu?Leu?Pro?Leu?Glu?Lys?Gly?Val?Ala?Tyr?Phe?Phe

85 90 95

Val?Ala?Leu?Pro?Ile?Ala?Ile?Val?Gly?Tyr?Phe?Ser?Ala?Lys?His?Gln

100 105 110

Gly?Asn?Val?Ala?Val?Ala?Gly?Met?Gln?Ile?Leu?Ala?Lys?Arg?Pro?Lys

115 120 125

Glu?Phe?Met?Lys?Gly?Ala?Ile?Leu?Ala?Ala?Met?Val?Glu?Thr?Tyr?Ala

130 135 140

Ile?Leu?Ala?Phe?Val?Val?Ser?Phe?Ile?Leu?Thr?Leu?Arg?Val

145 150 155

<210>92

<211>165

<212>PRT

＜213〉streptococcus pneumoniae

<400>92

Met?Leu?Lys?Ser?Glu?Lys?Gln?Ser?Arg?Tyr?Gln?Met?Leu?Asn?Glu?Glu

1 5 10 15

Leu?Ser?Phe?Leu?Leu?Glu?Gly?Glu?Thr?Asn?Val?Leu?Ala?Asn?Leu?Ser

20 25 30

Asn?Ala?Ser?Ala?Leu?Ile?Lys?Ser?Arg?Phe?Pro?Asn?Thr?Val?Phe?Ala

35 40 45

Gly?Phe?Tyr?Leu?Phe?Asp?Gly?Lys?Glu?Leu?Val?Leu?Gly?Pro?Phe?Gln

50 55 60

Gly?Gly?Val?Ser?Cys?Ile?Arg?Ile?Ala?Leu?Gly?Lys?Gly?Val?Cys?Gly

65 70 75 80

Glu?Ala?Ala?His?Phe?Gln?Glu?Thr?Val?Ile?Val?Gly?Asp?Val?Thr?Thr

85 90 95

Tyr?Leu?Asn?Tyr?Ile?Ser?Cys?Asp?Ser?Leu?Ala?Lys?Ser?Glu?Ile?Val

100 105 110

Val?Pro?Met?Met?Lys?Asn?Gly?Gln?Leu?Leu?Gly?Val?Leu?Asp?Leu?Asp

115 120 125

Ser?Ser?Glu?Ile?Glu?Asp?Tyr?Asp?Ala?Met?Asp?Arg?Asp?Tyr?Leu?Glu

130 135 140

Gln?Phe?Val?Ala?Ile?Leu?Leu?Glu?Lys?Thr?Ala?Trp?Asp?Phe?Thr?Met

145 150 155 160

Phe?Glu?Glu?Lys?Ser

165

<210>93

<211>256

<212>PRT

＜213〉streptococcus pneumoniae

<400>93

Met?Ser?Val?Leu?Glu?Ile?Lys?Asp?Leu?His?Val?Glu?Ile?Glu?Gly?Lys

1 5 10 15

Glu?Ile?Leu?Lys?Gly?Val?Asn?Leu?Thr?Leu?Lys?Thr?Gly?Glu?Ile?Ala

20 25 30

Ala?Ile?Met?Gly?Pro?Asn?Gly?Thr?Gly?Lys?Ser?Thr?Leu?Ser?Ala?Ala

35 40 45

Ile?Met?Gly?Asn?Pro?Asn?Tyr?Glu?Val?Thr?Lys?Gly?Glu?Val?Leu?Phe

50 55 60

Asp?Gly?Val?Asn?Ile?Leu?Glu?Leu?Glu?Val?Asp?Glu?Arg?Ala?Arg?Met

65 70 75 80

Gly?Leu?Phe?Leu?Ala?Met?Gln?Tyr?Pro?Ser?Glu?Ile?Pro?Gly?Ile?Thr

85 90 95

Asn?Ala?Glu?Phe?Leu?Arg?Ala?Ala?Met?Asn?Ala?Gly?Lys?Glu?Asp?Asp

100 105 110

Glu?Lys?Ile?Ser?Val?Arg?Glu?Phe?Ile?Thr?Lys?Leu?Asp?Glu?Lys?Met

115 120 125

Glu?Leu?Leu?Asn?Met?Lys?Glu?Glu?Met?Ala?Glu?Arg?Tyr?Leu?Asn?Glu

130 135 140

Gly?Phe?Ser?Gly?Gly?Glu?Lys?Lys?Arg?Asn?Glu?Ile?Leu?Gln?Leu?Leu

145 150 155 160

Met?Leu?Glu?Pro?Thr?Phe?Ala?Leu?Leu?Asp?Glu?Ile?Asp?Ser?Gly?Leu

165 170 175

Asp?Ile?Asp?Ala?Leu?Lys?Val?Val?Ser?Lys?Gly?Val?Asn?Ala?Met?Arg

180 185 190

Gly?Glu?Gly?Phe?Gly?Ala?Met?Ile?Ile?Thr?His?Tyr?Gln?Arg?Leu?Leu

195 200 205

Asn?Tyr?Ile?Thr?Pro?Asp?Val?Val?His?Val?Met?Met?Glu?Gly?Arg?Val

210 215 220

Val?Leu?Ser?Gly?Gly?Pro?Glu?Leu?Ala?Ala?Arg?Leu?Glu?Arg?Glu?Gly

225 230 235 240

Tyr?Ala?Lys?Leu?Ala?Glu?Glu?Leu?Gly?Tyr?Asp?Tyr?Lys?Glu?Glu?Leu

245 250 255

<210>94

<211>156

<212>PRT

＜213〉streptococcus pneumoniae

<400>94

Met?Pro?Tyr?Lys?Arg?Gln?Arg?Ser?Phe?Ser?Met?Ala?Leu?Ser?Lys?Leu

1 5 10 15

Asp?Ser?Leu?Tyr?Met?Ala?Val?Val?Ala?Asp?His?Ser?Lys?Asn?Pro?His

20 25 30

His?Gln?Gly?Lys?Leu?Glu?Asp?Ala?Glu?Gln?Ile?Ser?Leu?Asn?Asn?Pro

35 40 45

Thr?Cys?Gly?Asp?Val?Ile?Asn?Leu?Ser?Val?Lys?Phe?Asp?Ala?Glu?Asp

50 55 60

Arg?Leu?Glu?Asp?Ile?Ala?Phe?Leu?Asn?Ser?Gly?Cys?Thr?Ile?Ser?Thr

65 70 75 80

Ala?Ser?Ala?Ser?Met?Met?Thr?Asp?Ala?Val?Leu?Gly?Lys?Thr?Lys?Gln

85 90 95

Glu?Ile?Leu?Glu?Leu?Ala?Thr?Ile?Phe?Ser?Glu?Met?Val?Gln?Gly?Gln

100 105 110

Lys?Asp?Glu?Arg?Gln?Asp?Gln?Leu?Gly?Asp?Ala?Ala?Phe?Leu?Ser?Gly

115 120 125

Val?Ala?Lys?Phe?Pro?Gln?Arg?Ile?Lys?Cys?Ala?Thr?Leu?Ala?Trp?Asn

130 135 140

Ala?Leu?Lys?Lys?Thr?Ile?Glu?Asn?Gln?Glu?Lys?Gln

145 150 155

<210>95

<211>650

<212>PRT

＜213〉streptococcus pneumoniae

<400>95

Met?Lys?Ile?Gln?Asp?Leu?Leu?Arg?Lys?Asp?Val?Met?Leu?Leu?Asp?Leu

1 5 10 15

Gln?Ala?Thr?Glu?Lys?Thr?Ala?Val?Ile?Asp?Glu?Met?Ile?Lys?Asn?Leu

20 25 30

Thr?Asp?His?Gly?Tyr?Val?Thr?Asp?Phe?Glu?Thr?Phe?Lys?Glu?Gly?Ile

35 40 45

Leu?Ala?Arg?Glu?Ala?Leu?Thr?Ser?Thr?Gly?Leu?Gly?Asp?Gly?Ile?Ala

50 55 60

Met?Pro?His?Ser?Lys?Asn?Ala?Ala?Val?Lys?Glu?Ala?Thr?Val?Leu?Phe

65 70 75 80

Ala?Lys?Ser?Asn?Lys?Gly?Val?Asp?Tyr?Glu?Ser?Leu?Asp?Gly?Gln?Ala

85 90 95

Thr?Asp?Leu?Phe?Phe?Met?Ile?Ala?Ala?Pro?Glu?Gly?Ala?Asn?Asp?Thr

100 105 110

His?Leu?Ala?Ala?Leu?Ala?Glu?Leu?Ser?Gln?Tyr?Leu?Met?Lys?Asp?Gly

115 120 125

Phe?Ala?Asp?Lys?Leu?Arg?Gln?Ala?Thr?Ser?Ala?Asp?Gln?Val?Ile?Glu

130 135 140

Leu?Phe?Asp?Gln?Ala?Ser?Glu?Lys?Thr?Glu?Glu?Leu?Val?Gln?Ala?Pro

145 150 155 160

Ala?Asn?Asp?Ser?Gly?Asp?Phe?Ile?Val?Ala?Val?Thr?Ala?Cys?Thr?Thr

165 170 175

Gly?Ile?Ala?His?Thr?Tyr?Met?Ala?Gln?Glu?Ala?Leu?Gln?Lys?Val?Ala

180 185 190

Ala?Glu?Met?Gly?Val?Gly?Ile?Lys?Val?Glu?Thr?Asn?Gly?Ala?Ser?Gly

195 200 205

Val?Gly?Asn?Gln?Leu?Thr?Ala?Glu?Asp?Ile?Arg?Lys?Ala?Lys?Ala?Ile

210 215 220

Ile?Ile?Ala?Ala?Asp?Lys?Ala?Val?Glu?Met?Asp?Arg?Phe?Asp?Gly?Lys

225 230 235 240

Pro?Leu?Ile?Asn?Arg?Pro?Val?Ala?Asp?Gly?Ile?Arg?Lys?Thr?Glu?Glu

245 250 255

Leu?Ile?Asn?Leu?Ala?Leu?Ser?Gly?Asp?Thr?Glu?Val?Tyr?Arg?Ala?Ala

260 265 270

Asn?Gly?Ala?Lys?Ala?Ala?Thr?Ala?Ser?Asn?Glu?Lys?Gln?Ser?Leu?Gly

275 280 285

Gly?Ala?Leu?Tyr?Lys?His?Leu?Met?Ser?Gly?Val?Ser?Gln?Met?Leu?Pro

290 295 300

Phe?Val?Ile?Gly?Gly?Gly?Ile?Met?Ile?Ala?Leu?Ala?Phe?Leu?Ile?Asp

305 310 315 320

Gly?Ala?Leu?Gly?Val?Pro?Asn?Glu?Asn?Leu?Gly?Asn?Leu?Gly?Ser?Tyr

325 330 335

His?Glu?Leu?Ala?Ser?Met?Phe?Met?Lys?Ile?Gly?Gly?Ala?Ala?Phe?Gly

340 345 350

Leu?Met?Leu?Pro?Val?Phe?Ala?Gly?Tyr?Val?Ala?Tyr?Ser?Ile?Ala?Glu

355 360 365

Lys?Pro?Gly?Leu?Val?Ala?Gly?Phe?Val?Ala?Gly?Ala?Ile?Ala?Lys?Glu

370 375 380

Gly?Phe?Ala?Phe?Gly?Lys?Ile?Pro?Tyr?Ala?Ala?Gly?Gly?Glu?Ala?Thr

385 390 395 400

Ser?Thr?Leu?Ala?Gly?Val?Ser?Ser?Gly?Phe?Leu?Gly?Ala?Leu?Val?Gly

405 410 415

Gly?Phe?Ile?Ala?Gly?Ala?Leu?Val?Leu?Ala?Ile?Lys?Lys?Tyr?Val?Lys

420 425 430

Val?Pro?Arg?Ser?Leu?Glu?Gly?Ala?Lys?Ser?Ile?Leu?Leu?Leu?Pro?Leu

435 440 445

Leu?Gly?Thr?Ile?Leu?Thr?Gly?Phe?Val?Met?Leu?Ala?Val?Asn?Ile?Pro

450 455 460

Met?Ala?Ala?Ile?Asn?Thr?Ala?Met?Asn?Asp?Phe?Leu?Gly?Gly?Leu?Gly

465 470 475 480

Gly?Gly?Ser?Ala?Val?Leu?Leu?Gly?Ile?Val?Leu?Gly?Gly?Met?Met?Ala

485 490 495

Val?Asp?Met?Gly?Gly?Pro?Val?Asn?Lys?Ala?Ala?Tyr?Val?Phe?Gly?Thr

500 505 510

Gly?Thr?Leu?Ala?Ala?Thr?Val?Ser?Ser?Gly?Gly?Ser?Val?Ala?Met?Ala

515 520 525

Ala?Val?Met?Ala?Gly?Gly?Met?Val?Pro?Pro?Leu?Ala?Ile?Phe?Val?Ala

530 535 540

Thr?Leu?Leu?Phe?Lys?Asp?Lys?Phe?Thr?Lys?Glu?Glu?Arg?Asn?Ser?Gly

545 550 555 560

Leu?Thr?Asn?Ile?Ile?Met?Gly?Leu?Ser?Phe?Ile?Thr?Glu?Gly?Ala?Ile

565 570 575

Pro?Phe?Gly?Ala?Ala?Asp?Pro?Ala?Arg?Ala?Ile?Pro?Ser?Phe?Ile?Leu

580 585 590

Gly?Ser?Ala?Val?Ala?Gly?Gly?Leu?Val?Gly?Leu?Thr?Gly?Ile?Lys?Leu

595 600 605

Met?Ala?Pro?His?Gly?Gly?Ile?Phe?Val?Ile?Ala?Leu?Thr?Ser?Asn?Ala

610 615 620

Leu?Leu?Tyr?Leu?Val?Ser?Val?Leu?Val?Gly?Ala?Ile?Val?Ser?Gly?Val

625 630 635 640

Val?Tyr?Gly?Tyr?Leu?Arg?Lys?Pro?Gln?Ala

645 650

<210>96

<211>767

<212>PRT

＜213〉streptococcus pneumoniae

<400>96

Met?Ala?Asn?Lys?Asn?Thr?Ser?Thr?Thr?Arg?Arg?Arg?Pro?Ser?Lys?Ala

1 5 10 15

Glu?Leu?Glu?Arg?Lys?Glu?Ala?Ile?Gln?Arg?Met?Leu?Ile?Ser?Leu?Gly

20 25 30

Ile?Ala?Ile?Leu?Leu?Ile?Phe?Ala?Ala?Phe?Lys?Leu?Gly?Ala?Ala?Gly

35 40 45

Ile?Thr?Leu?Tyr?Asn?Leu?Ile?Arg?Leu?Leu?Val?Gly?Ser?Leu?Ala?Tyr

50 55 60

Leu?Ala?Ile?Phe?Gly?Leu?Leu?Ile?Tyr?Leu?Phe?Phe?Phe?Lys?Trp?Ile

65 70 75 80

Arg?Lys?Gln?Glu?Gly?Leu?Leu?Ser?Gly?Phe?Phe?Thr?Ile?Phe?Ala?Gly

85 90 95

Leu?Leu?Leu?Ile?Phe?Glu?Ala?Tyr?Leu?Val?Trp?Lys?Tyr?Gly?Leu?Asp

100 105 110

Lys?Ser?Val?Leu?Lys?Gly?Thr?Met?Ala?Gln?Val?Val?Thr?Asp?Leu?Thr

115 120 125

Gly?Phe?Arg?Thr?Thr?Ser?Phe?Ala?Gly?Gly?Gly?Leu?Ile?Gly?Val?Ala

130 135 140

Leu?Tyr?Ile?Pro?Thr?Ala?Phe?Leu?Phe?Ser?Asn?Ile?Gly?Thr?Tyr?Phe

145 150 155 160

Ile?Gly?Ser?Ile?Leu?Ile?Leu?Val?Gly?Ser?Leu?Leu?Val?Ser?Pro?Trp

165 170 175

Ser?Val?Tyr?Asp?Ile?Ala?Glu?Phe?Phe?Ser?Arg?Gly?Phe?Ala?Lys?Trp

180 185 190

Trp?Glu?Gly?His?Glu?Arg?Arg?Lys?Glu?Glu?Arg?Phe?Val?Lys?Gln?Glu

195 200 205

Glu?Lys?Ala?Arg?Gln?Lys?Ala?Glu?Lys?Glu?Ala?Arg?Leu?Glu?Gln?Glu

210 215 220

Glu?Thr?Glu?Lys?Ala?Leu?Leu?Asp?Leu?Pro?Pro?Val?Asp?Met?Glu?Thr

225 230 235 240

Gly?Glu?Ile?Leu?Thr?Glu?Glu?Ala?Val?Gln?Asn?Leu?Pro?Pro?Ile?Pro

245 250 255

Glu?Glu?Lys?Trp?Val?Glu?Pro?Glu?Ile?Ile?Leu?Pro?Gln?Ala?Glu?Leu

260 265 270

Lys?Phe?Pro?Glu?Gln?Glu?Asp?Asp?Ser?Asp?Asp?Glu?Asp?Val?Gln?Val

275 280 285

Asp?Phe?Ser?Ala?Lys?Glu?Ala?Leu?Glu?Tyr?Lys?Leu?Pro?Ser?Leu?Gln

290 295 300

Leu?Phe?Ala?Pro?Asp?Lys?Pro?Lys?Asp?Gln?Ser?Lys?Glu?Lys?Lys?Ile

305 310 315 320

Val?Arg?Glu?Asn?Ile?Lys?Ile?Leu?Glu?Ala?Thr?Phe?Ala?Ser?Phe?Gly

325 330 335

Ile?Lys?Val?Thr?Val?Glu?Arg?Ala?Glu?Ile?Gly?Pro?Ser?Val?Thr?Lys

340 345 350

Tyr?Glu?Val?Lys?Pro?Ala?Val?Gly?Val?Arg?Val?Asn?Arg?Ile?Ser?Asn

355 360 365

Leu?Ser?Asp?Asp?Leu?Ala?Leu?Ala?Leu?Ala?Ala?Lys?Asp?Val?Arg?Ile

370 375 380

Glu?Ala?Pro?Ile?Pro?Gly?Lys?Ser?Leu?Ile?Gly?Ile?Glu?Val?Pro?Asn

385 390 395 400

Ser?Asp?Ile?Ala?Thr?Val?Ser?Phe?Arg?Glu?Leu?Trp?Glu?Gln?Ser?Gln

405 410 415

Thr?Lys?Ala?Glu?Asn?Phe?Leu?Glu?Ile?Pro?Leu?Gly?Lys?Ala?Val?Asn

420 425 430

Gly?Thr?Ala?Arg?Ala?Phe?Asp?Leu?Ser?Lys?Met?Pro?His?Leu?Leu?Val

435 440 445

Ala?Gly?Ser?Thr?Gly?Ser?Gly?Lys?Ser?Val?Ala?Val?Asn?Gly?Ile?Ile

450 455 460

Ala?Ser?Ile?Leu?Met?Lys?Ala?Arg?Pro?Asp?Gln?Val?Lys?Phe?Met?Met

465 470 475 480

Val?Asp?Pro?Lys?Met?Val?Glu?Leu?Ser?Val?Tyr?Asn?Asp?Ile?Pro?His

485 490 495

Leu?Leu?Ile?Pro?Val?Val?Thr?Asn?Pro?Arg?Lys?Ala?Ser?Lys?Ala?Leu

500 505 510

Gln?Lys?Val?Val?Asp?Glu?Met?Glu?Asn?Arg?Tyr?Glu?Leu?Phe?Ala?Lys

515 520 525

Val?Gly?Val?Arg?Asn?Ile?Ala?Gly?Phe?Asn?Ala?Lys?Val?Glu?Glu?Phe

530 535 540

Asn?Ser?Gln?Ser?Glu?Tyr?Lys?Gln?Ile?Pro?Leu?Pro?Phe?Ile?Val?Val

545 550 555 560

Ile?Val?Asp?Glu?Leu?Ala?Asp?Leu?Met?Met?Val?Ala?Ser?Lys?Glu?Val

565 570 575

Glu?Asp?Ala?Ile?Ile?Arg?Leu?Gly?Gln?Lys?Ala?Arg?Ala?Ala?Gly?Ile

580 585 590

His?Met?Ile?Leu?Ala?Thr?Gln?Arg?Pro?Ser?Val?Asp?Val?Ile?Ser?Gly

595 600 605

Leu?Ile?Lys?Ala?Asn?Val?Pro?Ser?Arg?Val?Ala?Phe?Ala?Val?Ser?Ser

610 615 620

Gly?Thr?Asp?Ser?Arg?Thr?Ile?Leu?Asp?Glu?Asn?Gly?Ala?Glu?Lys?Leu

625 630 635 640

Leu?Gly?Arg?Gly?Asp?Met?Leu?Phe?Lys?Pro?Ile?Asp?Glu?Asn?His?Pro

645 650 655

Val?Arg?Leu?Gln?Gly?Ser?Phe?Ile?Ser?Asp?Asp?Asp?Val?Glu?Arg?Ile

660 665 670

Val?Asn?Phe?Ile?Lys?Thr?Gln?Ala?Asp?Ala?Asp?Tyr?Asp?Glu?Ser?Phe

675 680 685

Asp?Pro?Gly?Glu?Val?Ser?Glu?Asn?Glu?Gly?Glu?Phe?Ser?Asp?Gly?Asp

690 695 700

Ala?Gly?Gly?Asp?Pro?Leu?Phe?Glu?Glu?Ala?Lys?Ser?Leu?Val?Ile?Glu

705 710 715 720

Thr?Gln?Lys?Ala?Ser?Ala?Ser?Met?Ile?Gln?Arg?Arg?Leu?Ser?Val?Gly

725 730 735

Phe?Asn?Arg?Ala?Thr?Arg?Leu?Met?Glu?Glu?Leu?Glu?Ile?Ala?Gly?Val

740 745 750

Ile?Gly?Pro?Ala?Glu?Gly?Thr?Lys?Pro?Arg?Lys?Val?Leu?Gln?Gln

755 760 765

<210>97

<211>175

<212>PRT

＜213〉streptococcus pneumoniae

<400>97

Met?Ser?Tyr?Phe?Lys?Lys?Tyr?Lys?Phe?Asp?Lys?Ser?Gln?Phe?Lys?Leu

1 5 10 15

Gly?Met?Arg?Thr?Phe?Lys?Thr?Gly?Ile?Ala?Val?Phe?Leu?Val?Leu?Leu

20 25 30

Ile?Phe?Gly?Phe?Phe?Gly?Trp?Lys?Gly?Leu?Gln?Ile?Gly?Ala?Leu?Thr

35 40 45

Ala?Val?Phe?Ser?Leu?Arg?Glu?Ser?Phe?Asp?Glu?Ser?Val?His?Phe?Gly

50 55 60

Thr?Ser?Arg?Ile?Leu?Gly?Asn?Ser?Ile?Gly?Gly?Leu?Tyr?Ala?Leu?Val

65 70 75 80

Phe?Phe?Leu?Leu?Asn?Thr?Phe?Phe?His?Glu?Ala?Phe?Trp?Val?Thr?Leu

85 90 95

Val?Val?Val?Pro?Ile?Cys?Thr?Met?Leu?Thr?Ile?Met?Thr?Asn?Val?Ala

100 105 110

Met?Asn?Asn?Lys?Ala?Gly?ValIle?Gly?Gly?ValAla?Ala?Met?Leu?Ile

115 120 125

Ile?Thr?Leu?Ser?Ile?Pro?Ser?Gly?Glu?Thr?Ile?Leu?Tyr?Val?Phe?Val

130 135 140

Arg?Val?Leu?Glu?Thr?Phe?Met?Gly?Val?Phe?Val?Ala?Ile?Ile?Val?Asn

145 150 155 160

Tyr?Asp?Ile?Asp?Arg?Ile?Arg?Leu?Phe?Leu?Glu?Lys?Lys?Glu?Lys

165 170 175

<210>98

<211>156

<212>PRT

＜213〉streptococcus pneumoniae

<400>98

Met?Asn?Lys?Ser?Glu?His?Arg?His?Gln?Leu?Ile?Arg?Ala?Leu?Ile?Thr

1 5 10 15

Lys?Asn?Lys?Ile?His?Thr?Gln?Ala?Glu?Leu?Gln?Ala?Leu?Leu?Ala?Glu

20 25 30

Asn?Asp?Ile?Gln?Val?Thr?Gln?Ala?Thr?Leu?Ser?Arg?Asp?Ile?Lys?Asn

35 40 45

Met?Asn?Leu?Ser?Lys?Val?Arg?Glu?Glu?Asp?Ser?Ala?Tyr?Tyr?Val?Leu

50 55 60

Asn?Asn?Gly?Ser?Ile?Ser?Lys?Trp?Glu?Lys?Arg?Leu?Glu?Leu?Tyr?Met

65 70 75 80

Glu?Asp?Ala?Leu?Val?Trp?Met?Arg?Pro?Val?Gln?His?Gln?Val?Leu?Leu

85 90 95

Lys?Thr?Leu?Pro?Gly?Leu?Ala?Gln?Ser?Phe?Gly?Ser?Ile?Ile?Asp?Thr

100 105 110

Leu?Ser?Phe?Pro?Asp?Ala?Ile?Ala?Thr?Leu?Cys?Gly?Asn?Asp?Val?Cys

115 120 125

Leu?Ile?Ile?Cys?Glu?Asp?Ala?Asp?Thr?Ala?Gln?Lys?Cys?Phe?Glu?Glu

130 135 140

Leu?Lys?Lys?Phe?Ala?Pro?Pro?Phe?Phe?Phe?Glu?Glu

145 150 155

<210>99

<211>495

<212>PRT

＜213〉streptococcus pneumoniae

<400>99

Met?Lys?Ser?Ile?Lys?Leu?Asn?Ala?Leu?Ser?Tyr?Met?Gly?Ile?Arg?Val

1 5 10 15

Leu?Asn?Ile?Ile?Phe?Pro?Ile?Leu?Thr?Gly?Thr?Tyr?Val?Ala?Arg?Val

20 25 30

Leu?Asp?Arg?Thr?Asp?Tyr?Gly?Tyr?Phe?Asn?Ser?Val?Asp?Thr?Ile?Leu

35 40 45

Ser?Phe?Phe?Leu?Pro?Phe?Ala?Thr?Tyr?Gly?Val?Tyr?Asn?Tyr?Gly?Leu

50 55 60

Arg?Ala?Ile?Ser?Asn?Val?Lys?Asp?Asn?Lys?Lys?Asp?Leu?Asn?Arg?Thr

65 70 75 80

Phe?Ser?Ser?Leu?Phe?Tyr?Leu?Cys?Ile?Ala?Cys?Thr?Ile?Leu?Thr?Thr

85 90 95

Ala?Val?Tyr?Ile?Leu?Ala?Tyr?Pro?Leu?Phe?Phe?Thr?Asp?Asn?Pro?Ile

100 105 110

Val?Lys?Lys?Val?Tyr?Leu?Val?Met?Gly?Ile?Gln?Leu?Ile?Ala?Gln?Ile

115 120 125

Phe?Ser?Ile?Glu?Trp?Val?Asn?Glu?Ala?Leu?Glu?Asn?Tyr?Ser?Phe?Leu

130 135 140

Phe?Tyr?Lys?Thr?Ala?Phe?Ile?Arg?Ile?Leu?Met?Leu?Val?Ser?Ile?Phe

145 150 155 160

Leu?Phe?Val?Lys?Asn?Glu?His?Asp?Ile?Val?Val?Tyr?Thr?Leu?Val?Met

165 170 175

Ser?Leu?Ser?Thr?Leu?Ile?Asn?Tyr?Leu?Ile?Ser?Tyr?Phe?Trp?Ile?Lys

180 185 190

Arg?Asp?Ile?Lys?Leu?Val?Lys?Ile?His?Leu?Ser?Asp?Phe?Lys?Pro?Leu

195 200 205

Phe?Leu?Pro?Leu?Thr?Ala?Met?Leu?Val?Phe?Ala?Asn?Ala?Asn?Met?Leu

210 215 220

Phe?Thr?Phe?Leu?Asp?Arg?Leu?Phe?Leu?Val?Lys?Thr?Gly?Ile?Asp?Val

225 230 235 240

Asn?Val?Ser?Tyr?Tyr?Thr?Ile?Ala?Gln?Arg?Ile?Val?Thr?Val?Ile?Ala

245 250 255

Gly?Val?Val?Thr?Gly?Ala?Ile?Gly?Val?Ser?Val?Pro?Arg?Leu?Ser?Tyr

260 265 270

Tyr?Leu?Gly?Lys?Gly?Asp?Lys?Glu?Ala?Tyr?Val?Ser?Leu?Val?Asn?Arg

275 280 285

Gly?Ser?Arg?Ile?Phe?Asn?Phe?Phe?Ile?Ile?Pro?Leu?Ser?Phe?Gly?Leu

290 295 300

Met?Val?Leu?Gly?Pro?Asn?Ala?Ile?Leu?Leu?Tyr?Gly?Ser?Glu?Lys?Tyr

305 310 315 320

Ile?Gly?Gly?Gly?Ile?Leu?Thr?Ser?Leu?Phe?Ala?Phe?Arg?Thr?Ile?Ile

325 330 335

Leu?Ala?Leu?Asp?Thr?Ile?Leu?Gly?Ser?Gln?Ile?Leu?Phe?Thr?Asn?Gly

340 345 350

Tyr?Glu?Lys?Arg?Ile?Thr?Val?Tyr?Thr?Val?Phe?Ala?Gly?Leu?Leu?Asn

355 360 365

Leu?Gly?Leu?Asn?Ser?Leu?Leu?Phe?Phe?Asn?His?Ile?Val?Ala?Pro?Glu

370 375 380

Tyr?Tyr?Leu?Leu?Thr?Thr?Met?Leu?Ser?Glu?Thr?Ser?Leu?Leu?Val?Phe

385 390 395 400

Tyr?Ile?Ile?Phe?Ile?His?Arg?Lys?Gln?Leu?Ile?His?Leu?Gly?His?Ile

405 410 415

Phe?Ser?Tyr?Thr?Val?Arg?Tyr?Ser?Leu?Phe?Ser?Leu?Ser?Phe?Val?Ala

420 425 430

Ile?Tyr?Phe?Leu?Ile?Asn?Phe?Val?Tyr?Pro?Val?Asp?Met?Val?Ile?Asn

435 440 445

Leu?Pro?Phe?Leu?Ile?Asn?Thr?Gly?Leu?Ile?Val?Leu?Leu?Ser?Ala?Ile

450 455 460

Ser?Tyr?Ile?Ser?Leu?Leu?Val?Phe?Thr?Lys?Asp?Ser?Ile?Phe?Tyr?Glu

465 470 475 480

Phe?Leu?Asn?His?Val?Leu?Ala?Leu?Lys?Asn?Lys?Phe?Lys?Lys?Ser

485 490 495

<210>100

<211>286

<212>PRT

＜213〉streptococcus pneumoniae

<400>100

Met?Glu?Leu?Phe?Met?Lys?Ile?Thr?Asn?Tyr?Glu?Ile?Tyr?Lys?Leu?Lys

1 5 10 15

Lys?Ser?Gly?Leu?Thr?Asn?Gln?Gln?Ile?Leu?Lys?Val?Leu?Glu?Tyr?Gly

20 25 30

Glu?Asn?Val?Asp?Gln?Glu?Leu?Leu?Leu?Gly?Asp?Ile?Ala?Asp?Ile?Ser

35 40 45

Gly?Cys?Arg?Asn?Pro?Ala?Val?Phe?Met?Glu?Arg?Tyr?Phe?Gln?Ile?Asp

50 55 60

Asp?Ala?His?Leu?Ser?Lys?Glu?Phe?Gln?Lys?Phe?Pro?Ser?Phe?Ser?Ile

65 70 75 80

Leu?Asp?Asp?Cys?Tyr?Pro?Trp?Asp?Leu?Ser?Glu?Ile?Tyr?Asp?Ala?Pro

85 90 95

Val?Leu?Leu?Phe?Tyr?Lys?Gly?Asn?Leu?Asp?Leu?Leu?Lys?Phe?Pro?Lys

100 105 110

Val?Ala?Val?Val?Gly?Ser?Arg?Ala?Cys?Ser?Lys?Gln?Gly?Ala?Lys?Ser

115 120 125

Val?Glu?Lys?Val?Ile?Gln?Gly?Leu?Glu?Asn?Glu?Leu?Val?Ile?Val?Ser

130 135 140

Gly?Leu?Ala?Lys?Gly?Ile?Asp?Thr?Ala?Ala?His?Met?Ala?Ala?Leu?Gln

145 150 155 160

Asn?Gly?Gly?Lys?Thr?Ile?Ala?Val?Ile?Gly?Thr?Gly?Leu?Asp?Val?Phe

165 170 175

Tyr?Pro?Lys?Ala?Asn?Lys?Arg?Leu?Gln?Asp?Tyr?Ile?Gly?Asn?Asp?His

180 185 190

Leu?Val?Leu?Ser?Glu?Tyr?Gly?Pro?Gly?Glu?Gln?Pro?Leu?Lys?Phe?His

195 200 205

Phe?Pro?Ala?Arg?Asn?Arg?Ile?Ile?Ala?Gly?Leu?Cys?Arg?Gly?Val?Ile

210 215 220

Val?Ala?Glu?Ala?Lys?Met?Arg?Ser?Gly?Ser?Leu?Ile?Thr?Cys?Glu?Arg

225 230 235 240

Ala?Met?Glu?Glu?Gly?Arg?Asp?Val?Phe?Ala?Ile?Pro?Gly?Ser?Ile?Leu

245 250 255

Asp?Gly?Leu?Ser?Asp?Gly?Cys?His?His?Leu?Ile?Gln?Glu?Gly?Ala?Lys

260 265 270

Leu?Val?Thr?Ser?Gly?Gln?Asp?Val?Leu?Ala?Glu?Phe?Glu?Phe

275 280 285

<210>101

<211>267

<212>PRT

＜213〉streptococcus pneumoniae

<400>101

Met?Lys?Gln?Leu?Thr?Val?Glu?Asp?Ala?Lys?Gln?Ile?Glu?Leu?Glu?Ile

1 5 10 15

Leu?Asp?Tyr?Ile?Asp?Thr?Leu?Cys?Lys?Lys?His?Asn?Ile?Asn?Tyr?Ile

20 25 30

Ile?Asn?Tyr?Gly?Thr?Leu?Ile?Gly?Ala?Val?Arg?His?Glu?Gly?Phe?Ile

35 40 45

Pro?Trp?Asp?Asp?Asp?Ile?Asp?Leu?Ser?Met?Pro?Arg?Glu?Asp?Tyr?Gln

50 55 60

Arg?Phe?Ile?Asn?Ile?Phe?Gln?Lys?Glu?Lys?Ser?Lys?Tyr?Lys?Leu?Leu

65 70 75 80

Ser?Leu?Glu?Thr?Asp?Lys?Asn?Tyr?Phe?Asn?Asn?Phe?Ile?Lys?Ile?Thr

85 90 95

Asp?Ser?Thr?Thr?Lys?Ile?Ile?Asp?Thr?Arg?Asn?Thr?Lys?Thr?Tyr?Glu

100 105 110

Ser?Gly?Ile?Phe?Ile?Asp?Ile?Phe?Pro?Ile?Asp?Arg?Phe?Asp?Asp?Pro

115 120 125

Lys?Val?Ile?Asp?Thr?Cys?Tyr?Lys?Leu?Glu?Ser?Phe?Lys?Leu?Leu?Ser

130 135 140

Phe?Ser?Lys?His?Lys?Asn?Ile?Val?Tyr?Lys?Asp?Ser?Leu?Leu?Lys?Asp

145 150 155 160

Trp?Ile?Arg?Thr?Ala?Phe?Trp?Leu?Leu?Leu?Arg?Pro?Val?Ser?Pro?Arg

165 170 175

Tyr?Phe?Ala?Asn?Lys?Ile?Glu?Lys?Glu?Ile?Gln?Lys?Tyr?Ser?Arg?Glu

180 185 190

Asn?Gly?Gln?Tyr?Met?Ala?Phe?Ile?Pro?Ser?Lys?Phe?Lys?Glu?Lys?Glu

195 200 205

Val?Phe?Pro?Ser?Gly?Thr?Phe?Asp?Lys?Thr?Ile?Asp?Leu?Pro?Phe?Glu

210 215 220

Asn?Leu?Ser?Leu?Pro?Ala?Pro?Glu?Lys?Phe?Asp?Thr?Ile?Leu?Thr?Gln

225 230 235 240

Phe?Tyr?Gly?Asp?Tyr?Met?Thr?Leu?Pro?Pro?Glu?Glu?Lys?Arg?Phe?Tyr

245 250 255

Ser?His?Glu?Phe?His?Ala?Tyr?Lys?Leu?Glu?Asp

260 265

<210>102

<211>508

<212>PRT

＜213〉streptococcus pneumoniae

<400>102

Met?Ile?Lys?Ile?Asn?His?Leu?Thr?Ile?Thr?Gln?Asn?Lys?Asp?Leu?Arg

1 5 10 15

Asp?Leu?Val?Ser?Asp?Leu?Thr?Met?Thr?Ile?Gln?Asp?Gly?Glu?Lys?Val

20 25 30

Ala?Ile?Ile?Gly?Glu?Glu?Gly?Asn?Gly?Lys?Ser?Thr?Leu?Leu?Lys?Ile

35 40 45

Leu?Met?Gly?Glu?Ala?Leu?Ser?Asp?Phe?Thr?Ile?Lys?Gly?Asn?Ile?Gln

50 55 60

Ser?Asp?Tyr?Gln?Ser?Leu?Ala?Tyr?Ile?Pro?Gln?Lys?Val?Pro?Glu?Asp

65 70 75 80

Leu?Lys?Lys?Lys?Thr?Leu?His?Asp?Tyr?Phe?Phe?Leu?Asp?Ser?Ile?Asp

85 90 95

Leu?Asp?Tyr?Ser?Ile?Leu?Tyr?Arg?Leu?Ala?Glu?Glu?Leu?His?Phe?Asp

100 105 110

Ser?Asn?Arg?Phe?Ala?Ser?Asp?Gln?Glu?Ile?Gly?Asn?Leu?Ser?Gly?Gly

115 120 125

Glu?Ala?Leu?Lys?Ile?Gln?Leu?Ile?His?Glu?Leu?Ala?Lys?Pro?Phe?Glu

130 135 140

Ile?Leu?Phe?Leu?Asp?Glu?Pro?Ser?Asn?Asp?Leu?Asp?Leu?Glu?Thr?Val

145 150 155 160

Asp?Trp?Leu?Lys?Gly?Gln?Ile?Gln?Lys?Thr?Arg?Gln?Thr?Val?Ile?Phe

165 170 175

Ile?Ser?His?Asp?Glu?Asp?Phe?Leu?Ser?Glu?Thr?Ala?Asp?Thr?Ile?Val

180 185 190

His?Leu?Arg?Leu?Val?Lys?His?Arg?Lys?Glu?Ala?Glu?Thr?Leu?Val?Glu

195 200 205

His?Leu?Asp?Tyr?Asp?Ser?Tyr?Ser?Glu?Gln?Arg?Lys?Ala?Asn?Phe?Ala

210 215 220

Lys?Gln?Ser?Gln?Gln?Ala?Ala?Asn?Asn?Gln?Arg?Ala?Tyr?Asp?Lys?Thr

225 230 235 240

Met?Glu?Lys?His?Arg?Arg?Val?Lys?Gln?Asn?Val?Glu?Thr?Ala?Leu?Arg

245 250 255

Ala?Thr?Lys?Asp?Ser?Thr?Ala?Gly?Arg?Leu?Leu?Ala?Lys?Lys?Met?Lys

260 265 270

Thr?Val?Leu?Ser?Gln?Glu?Lys?Arg?Tyr?Glu?Lys?Ala?Ala?Gln?Ser?Met

275 280 285

Thr?Gln?Lys?Pro?Leu?Glu?Glu?Glu?Gln?Ile?Gln?Leu?Phe?Phe?Ser?Asp

290 295 300

Ile?Gln?Pro?Leu?Pro?Ala?Ser?Lys?Val?Leu?Val?Gln?Leu?Glu?Lys?Glu

305 310 315 320

Asn?Leu?Ser?Ile?Asp?Asp?Arg?Val?Leu?Val?Gln?Lys?Leu?Gln?Leu?Thr

325 330 335

Val?Arg?Gly?Gln?Glu?Lys?Ile?Gly?Ile?Ile?Gly?Pro?Asn?Gly?Val?Gly

340 345 350

Lys?Ser?Thr?Leu?Leu?Ala?Lys?Leu?Gln?Arg?Leu?Leu?Asn?Asp?Lys?Arg

355 360 365

Glu?Ile?Ser?Leu?Gly?Phe?Met?Pro?Gln?Asp?Tyr?His?Lys?Lys?Leu?Gln

370 375 380

Leu?Asp?Leu?Ser?Pro?Ile?Ala?Tyr?Leu?Ser?Lys?Thr?Gly?Glu?Lys?Glu

385 390 395 400

Glu?Leu?Gln?Lys?Ile?Gln?Ser?His?Leu?Ala?Ser?Leu?Asn?Phe?Ser?Tyr

405 410 415

Pro?Glu?Met?Gln?His?Gln?Ile?Arg?Ser?Leu?Ser?Gly?Gly?Gln?Gln?Gly

420 425 430

Lys?Leu?Leu?Leu?Leu?Asp?Leu?Val?Leu?Arg?Lys?Pro?Asn?Phe?Leu?Leu

435 440 445

Leu?Asp?Glu?Pro?Thr?Arg?Asn?Phe?Ser?Pro?Thr?Ser?Gln?Pro?Gln?Ile

450 455 460

Arg?Lys?Leu?Phe?Ala?Thr?Tyr?Pro?Gly?Gly?Leu?Ile?Thr?Val?Ser?His

465 470 475 480

Asp?Arg?Arg?Phe?Leu?Lys?Glu?Val?Cys?Ser?Ile?Ile?Tyr?Arg?Met?Thr

485 490 495

Glu?His?Gly?Leu?Lys?Leu?Val?Asn?Leu?Glu?Asp?Leu

500 505

<210>103

<211>237

<212>PRT

＜213〉streptococcus pneumoniae

<400>103

Met?Lys?Pro?Lys?Thr?Phe?Tyr?Asn?Leu?Leu?Ala?Glu?Gln?Asn?Leu?Pro

1 5 10 15

Leu?Ser?Asp?Gln?Gln?Lys?Glu?Gln?Phe?Glu?Arg?Tyr?Phe?Glu?Leu?Leu

20 25 30

Val?Glu?Trp?Asn?Glu?LysIle?Asn?Leu?Thr?Ala?Ile?Thr?Asp?Lys?Glu

35 40 45

Glu?Val?Tyr?Leu?Lys?His?Phe?Tyr?Asp?Ser?Ile?Ala?Pro?Ile?Leu?Gln

50 55 60

Gly?Leu?Ile?Pro?Asn?Glu?Thr?Ile?Lys?Leu?Leu?Asp?Ile?Gly?Ala?Gly

65 70 75 80

Ala?Gly?Phe?Pro?Ser?Leu?Pro?Met?Lys?Ile?Leu?Tyr?Pro?Glu?Leu?Asp

85 90 95

Val?Thr?Ile?Ile?Asp?Ser?Leu?Asn?Lys?Arg?Ile?Asn?Phe?Leu?Gln?Leu

100 105 110

Leu?Ala?Gln?Glu?Leu?Asp?Leu?Asn?Gly?Val?His?Phe?Tyr?His?Gly?Arg

115 120 125

Ala?Glu?Asp?Phe?Ala?Gln?Asp?Lys?Asn?Phe?Arg?Ala?Gln?Tyr?Asp?Phe

130 135 140

Val?Thr?Ala?Arg?Ala?Val?Ala?Arg?Met?Gln?Val?Leu?Ser?Glu?Leu?Thr

145 150 155 160

Ile?Pro?Tyr?Leu?Lys?Val?Gly?Gly?Lys?Leu?Leu?Ala?Leu?Lys?Ala?Ser

165 170 175

Asn?Ala?Pro?Glu?Glu?Leu?Leu?Glu?Ala?Lys?Asn?Ala?Leu?Asn?Leu?Leu

180 185 190

Phe?Ser?Lys?Val?Glu?Asp?Asn?Leu?Ser?Tyr?Ala?Leu?Pro?Asn?Arg?Asp

195 200 205

Pro?Arg?Tyr?Ile?Thr?Val?Val?Glu?Lys?Lys?Lys?Glu?Thr?Pro?Asn?Lys

210 215 220

Tyr?Pro?Arg?Lys?Ala?Gly?Met?Pro?Asn?Lys?Arg?Pro?Leu

225 230 235

<210>104

<211>268

<212>PRT

＜213〉streptococcus pneumoniae

<400>104

Met?Ser?Ile?Lys?Leu?Ile?Ala?Val?Asp?Ile?Asp?Gly?Thr?Leu?Val?Asn

1 5 10 15

Ser?Gln?Lys?Glu?Ile?Thr?Pro?Glu?Val?Phe?Ser?Ala?Ile?Gln?Asp?Ala

20 25 30

Lys?Glu?Ala?Gly?Val?Lys?Val?Val?Ile?Ala?Thr?Gly?Arg?Pro?Ile?Ala

35 40 45

Gly?Val?Ala?Lys?Leu?Leu?Asp?Asp?Leu?Gln?Leu?Arg?Asp?Glu?Gly?Asp

50 55 60

Tyr?Val?Val?Thr?Phe?Asn?Gly?Ala?Leu?Val?Gln?Glu?Thr?Ala?Thr?Gly

65 70 75 80

His?Glu?Ile?Ile?Ser?Glu?Ser?Leu?Thr?Tyr?Glu?Asp?Tyr?Leu?Asp?Met

85 90 95

Glu?Phe?Leu?Ser?Arg?Lys?Leu?Gly?Val?His?Met?His?Ala?Ile?Thr?Lys

100 105 110

Asp?Gly?Ile?Tyr?Thr?Ala?Asn?Arg?Asn?Ile?Gly?Lys?Tyr?Thr?Val?His

115 120 125

Glu?Ser?Thr?Leu?Val?Ser?Met?Pro?Ile?Phe?Tyr?Arg?Thr?Pro?Glu?Glu

130 135 140

Met?Ala?Gly?Lys?Glu?Ile?Val?Lys?Cys?Met?Phe?Ile?Asp?Glu?Pro?Glu

145 150 155 160

Ile?Leu?Asp?Ala?Ala?Ile?Glu?Lys?Ile?Pro?Ala?Glu?Phe?Tyr?Glu?Arg

165 170 175

Tyr?Ser?Ile?Asn?Lys?Ser?Ala?Pro?Phe?Tyr?Leu?Glu?Leu?Leu?Lys?Lys

180 185 190

Asn?Val?Asp?Lys?Gly?Ser?Ala?Ile?Thr?His?Leu?Ala?Glu?Lys?Leu?Gly

195 200 205

Leu?Thr?Lys?Asp?Glu?Thr?Met?Ala?Ile?Gly?Asp?Glu?Glu?Asn?Asp?Arg

210 215 220

Ala?Met?Leu?Glu?Val?Val?Gly?Asn?Pro?Val?Val?Met?Glu?Asn?Gly?Asn

225 230 235 240

Pro?Glu?Ile?Lys?Lys?Ile?Ala?Lys?Tyr?Ile?Thr?Lys?Thr?Asn?Asp?Glu

245 250 255

Ser?Gly?Val?Ala?His?Ala?Ile?Arg?Thr?Trp?Val?Leu

260 265

<210>105

<211>186

<212>PRT

＜213〉streptococcus pneumoniae

<400>105

Met?Thr?Trp?Ile?Ile?Leu?Gly?Val?Ile?Ala?Leu?Ile?Val?Ile?Phe?Val

1 5 10 15

Ile?Val?Ser?Tyr?Asn?Gly?Leu?Val?Lys?Asn?Arg?Met?Gln?Thr?Lys?Glu

20 25 30

Ala?Trp?Ser?Gln?Ile?Asp?Val?Gln?Leu?Lys?Arg?Arg?Asn?Asp?Leu?Leu

35 40 45

Pro?Asn?Leu?Ile?Glu?Thr?Val?Lys?Gly?TyrAla?Lys?Tyr?Glu?Gly?Ser

50 55 60

Thr?Leu?Glu?Lys?Val?Ala?Glu?Leu?Arg?Asn?Gln?Val?Ala?Ala?Ala?Thr

65 70 75 80

Ser?Pro?Ala?Glu?Ala?Met?Lys?Ala?Ser?Asp?Ala?Leu?Thr?Arg?Gln?Val

85 90 95

Ser?GIy?Ile?Phe?Ala?Val?Ala?Glu?Ser?Tyr?Pro?Asp?Leu?Lys?Ala?Ser

100 105 110

Ala?Asn?Phe?Val?Lys?Leu?Gln?Glu?Glu?Leu?Thr?Asn?Thr?Glu?Asn?Lys

115 120 125

Ile?Ser?Tyr?Ser?Arg?Gln?Leu?Tyr?Asn?Ser?Val?Val?Ser?Asn?Tyr?Asn

130 135 140

Val?Lys?Leu?Glu?Thr?Phe?Pro?Ser?Asn?Ile?Ile?Ala?Gly?Met?Phe?Gly

145 150 155 160

Phe?Lys?Ala?Ala?Asp?Phe?Leu?Gln?Thr?Pro?Glu?Glu?Glu?Lys?Ser?Val

165 170 175

Pro?Lys?Val?Asp?Phe?Ser?Gly?Leu?Gly?Asp

180 185

<210>106

<211>299

<212>PRT

＜213〉streptococcus pneumoniae

<400>106

Met?Leu?Phe?Asp?Gln?Ile?Ala?Ser?Asn?Lys?Arg?Lys?Thr?Trp?Ile?Leu

1 5 10 15

Leu?Leu?Val?Phe?Phe?Leu?Leu?Leu?Ala?Leu?Val?Gly?Tyr?Ala?Val?Gly

20 25 30

Tyr?Leu?Phe?Ile?Arg?Ser?Gly?Leu?Gly?Gly?Leu?Val?Ile?Ala?Leu?Ile

35 40 45

Ile?Gly?Phe?Ile?Tyr?Ala?Leu?Ser?Met?Ile?Phe?Gln?Ser?Thr?Glu?Ile

50 55 60

Val?Met?Ser?Met?Asn?Gly?Ala?Arg?Glu?Val?Asp?Glu?Gln?Thr?Ala?Pro

65 70 75 80

Asp?Leu?Tyr?His?Val?Val?Glu?Asp?Met?Ala?Leu?Val?Ala?Gln?Ile?Pro

85 90 95

Met?Pro?Arg?Val?Phe?Ile?Ile?Asp?Asp?Pro?Ala?Leu?Asn?Ala?Phe?Ala

100 105 110

Thr?Gly?Ser?Asn?Pro?Gln?Asn?Ala?Ala?Val?Ala?Ala?Thr?Ser?Gly?Leu

115 120 125

Leu?Ala?Ile?Met?Asn?Arg?Glu?Glu?Leu?Glu?Ala?Val?Met?Gly?His?Glu

130 135 140

Val?Ser?His?Ile?Arg?Asn?Tyr?Asp?Ile?Arg?Ile?Ser?Thr?Ile?Ala?Val

145 150 155 160

Ala?Leu?Ala?Ser?Ala?Ile?Thr?Met?Leu?Ser?Ser?Met?Ala?Gly?Arg?Met

165 170 175

Met?Trp?Trp?Gly?Gly?Ala?Gly?Arg?Arg?Arg?Ser?Asp?Asp?Asp?Arg?Asp

180 185 190

Gly?Asn?Gly?Leu?Glu?Ile?Ile?Met?Leu?Val?Val?Ser?Leu?Leu?Ala?Ile

195 200 205

Val?Leu?Ala?Pro?Leu?Ala?Ala?Thr?Leu?Val?Gln?Leu?Ala?Ile?Ser?Arg

210 215 220

Gln?Arg?Glu?Phe?Leu?Ala?Asp?Ala?Ser?Ser?Val?Glu?Leu?Thr?Arg?Asn

225 230 235 240

Pro?Gln?Gly?Met?Ile?Asn?Ala?Leu?Asp?Lys?Leu?Asp?Asn?Ser?Lys?Pro

245 250 255

Met?Ser?Arg?His?Val?Asp?Asp?Ala?Ser?Ser?Ala?Leu?Tyr?Ile?Asn?Asp

260 265 270

Pro?Lys?Lys?Gly?Gly?Gly?Phe?Gln?Lys?Leu?Phe?Tyr?Thr?His?Pro?Pro

275 280 285

Ile?Ser?Glu?Arg?Ile?Glu?Arg?Leu?Lys?Gln?Met

290 295

<210>107

<211>180

<212>PRT

＜213〉streptococcus pneumoniae

<400>107

Met?Lys?Leu?Asn?Ile?Gln?Glu?Ile?Arg?Lys?Gln?Ser?Glu?Gly?Leu?Asn

1 5 10 15

Phe?Glu?Gln?Thr?Leu?Asp?Leu?Val?Asp?Asp?Leu?Arg?Ala?Arg?Asn?Gln

20 25 30

Glu?Ile?Leu?Asp?Val?Lys?Asp?Ile?Leu?Ala?Val?Gly?Lys?Val?Gln?Tyr

35 40 45

Glu?Asp?Arg?Met?Tyr?Phe?Leu?Asp?Tyr?Gln?Leu?Ser?Tyr?Thr?Ile?Val

50 55 60

Leu?Ala?Ser?Ser?Arg?Ser?Met?Glu?Pro?Val?Glu?Leu?Val?Glu?Ser?Tyr

65 70 75 80

Pro?Val?Thr?Glu?Val?Phe?Met?Glu?Gly?Ala?Thr?Asn?Gln?Leu?Asp?Gln

85 90 95

Glu?Val?Leu?Asp?Asp?Asp?Leu?Val?Leu?Pro?Ile?Glu?Asn?Gly?Glu?Leu

100 105 110

Asp?Leu?Ala?Glu?Ser?Val?Ser?Asp?Asn?Ile?Leu?Leu?Asn?Ile?Pro?Ile

115 120 125

Lys?Val?Leu?Thr?Ala?Glu?Glu?Glu?Ala?Gly?Gln?Gly?Phe?Ile?Ser?Gly

130 135 140

Asn?Asp?Trp?Gln?Ile?Met?Thr?Glu?Glu?Glu?Tyr?Gln?Ala?Gln?Lys?Ala

145 150 155 160

Val?Lys?Lys?Glu?Glu?Asn?Ser?Pro?Phe?Ala?Gly?Leu?Gln?Gly?Leu?Phe

165 170 175

Asp?Gly?Asp?Glu

180

<210>108

<211>177

<212>PRT

＜213〉streptococcus pneumoniae

<400>108

Met?Lys?Arg?Gln?Leu?Ala?Leu?Val?Val?Phe?Ser?Gly?Gly?Gln?Asp?Ser

1 5 10 15

Thr?Thr?Cys?Leu?Phe?Trp?Val?Met?Gln?His?Tyr?Glu?Thr?Val?Glu?Ala

20 25 30

Val?Thr?Phe?Ala?Tyr?Gly?Gln?Arg?His?His?Leu?Glu?Ile?Gln?Ile?Thr

35 40 45

Arg?Glu?Ile?Ala?Lys?Glu?Gln?Gly?Ile?Arg?His?His?Ile?Leu?Asp?Met

50 55 60

Ser?Leu?Leu?Gly?Gln?Ile?Thr?Ala?Gln?Pro?Asp?Phe?Ala?Thr?Ile?His

65 70 75 80

Ile?Ser?Tyr?Ile?Pro?Asp?Lys?Leu?Cys?Val?Glu?Ser?Lys?Ser?Leu?Lys

85 90 95

Leu?Tyr?Leu?Phe?Ser?Tyr?Arg?Asn?His?Gly?Asp?Phe?His?Glu?Asn?Cys

100 105 110

Ile?Asn?Thr?Ile?Gly?Lys?Asp?Leu?Val?Asn?Leu?Leu?Asp?Pro?Arg?Tyr

115 120 125

Leu?Glu?Val?Trp?Gly?Lys?Phe?Thr?Pro?Arg?Gly?Gly?Ile?Ser?Ile?Asp

130 135 140

Pro?Tyr?Tyr?Asn?Tyr?Gly?Lys?Gln?Gly?Thr?Lys?Tyr?Glu?Gly?Leu?Ala

145 150 155 160

Glu?Gln?Arg?Leu?Phe?Gln?His?Asp?Leu?Tyr?Pro?Glu?Lys?Ile?Asp?Asn

165 170 175

Arg

<210>109

<211>1236

<212>PRT

＜213〉streptococcus pneumoniae

<400>109

Met?Thr?Glu?Thr?Val?Glu?Asp?Lys?Val?Ser?His?Ser?Ile?Thr?Gly?Leu

1 5 10 15

Asp?Ile?Leu?Lys?Gly?Ile?Val?Ala?Ala?Gly?Ala?Val?Ile?Ser?Gly?Thr

20 25 30

Val?Ala?Thr?Gln?Thr?Lys?Val?Phe?Thr?Asn?Glu?Ser?Ala?ValLeu?Glu

35 40 45

Lys?Thr?Val?Glu?Lys?Thr?Asp?Ala?Leu?Ala?Thr?Asn?Asp?Thr?Val?Val

50 55 60

Leu?Gly?Thr?Ile?Ser?Thr?Ser?Asn?Ser?Ala?Ser?Ser?Thr?Ser?Leu?Ser

65 70 75 80

Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser

85 90 95

Ala?Ser?Thr?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser

100 105 110

Ala?Ser?Thr?Ser?Ile?Ser?Ala?Ser?Ser?Thr?Val?Val?Gly?Ser?Gln?Thr

115 120 125

Ala?Ala?Ala?Thr?Glu?Ala?Thr?Ala?Lys?Lys?Val?Glu?Glu?Asp?Arg?Lys

130 135 140

Lys?Pro?Ala?Ser?Asp?Tyr?Val?Ala?Ser?Val?Thr?Asn?Val?Asn?Leu?Gln

145 150 155 160

Ser?Tyr?Ala?Lys?Arg?Arg?Lys?Arg?Ser?Val?Asp?Ser?Ile?Glu?Gln?Leu

165 170 175

Leu?Ala?Ser?Ile?Lys?Asn?Ala?Ala?Val?Phe?Ser?Gly?Asn?Thr?Ile?Val

180 185 190

Asn?Gly?Ala?Pro?Ala?Ile?Asn?Ala?Ser?Leu?Asn?Ile?Ala?Lys?Ser?Glu

195 200 205

Thr?Lys?Val?Tyr?Thr?Gly?Glu?Gly?Val?Asp?Ser?Val?Tyr?Arg?Val?Pro

210 215 220

Ile?Tyr?Tyr?Lys?Leu?Lys?Val?Thr?Asn?Asp?Gly?Ser?Lys?Leu?Thr?Phe

225 230 235 240

Thr?Tyr?Thr?Val?Thr?Tyr?Val?Asn?Pro?Lys?Thr?Asn?Asp?Leu?Gly?Asn

245 250 255

Ile?Ser?Ser?Met?Arg?Pro?Gly?Tyr?Ser?Ile?Tyr?Asn?Ser?Gly?Thr?Ser

260 265 270

Thr?Gln?Thr?Met?Leu?Thr?Leu?Gly?Ser?Asp?Leu?Gly?Lys?Pro?Ser?Gly

275 280 285

Val?Lys?Asn?Tyr?Ile?Thr?Asp?Lys?Asn?Gly?Arg?Gln?Val?Leu?Ser?Tyr

290 295 300

Asn?Thr?Ser?Thr?Met?Thr?Thr?Gln?Gly?Ser?Gly?Tyr?Thr?Trp?Gly?Asn

305 310 315 320

Gly?Ala?Gln?Met?Asn?Gly?Phe?Phe?Ala?Lys?Lys?Gly?Tyr?Gly?Leu?Thr

325 330 335

Ser?Ser?Trp?Thr?Val?Pro?Ile?Thr?Gly?Thr?Asp?Thr?Ser?Phe?Thr?Phe

340 345 350

Thr?Pro?Tyr?Ala?Ala?Arg?Thr?Asp?Arg?Ile?Gly?Ile?Asn?Tyr?Phe?Asn

355 360 365

Gly?Gly?Gly?Lys?Val?Val?Glu?Ser?Ser?Thr?Thr?Ser?Gln?Ser?Leu?Ser

370 375 380

Gln?Ser?Lys?Ser?Leu?Ser?Val?Ser?Ala?Ser?Gln?Ser?Ala?Ser?Ala?Ser

385 390 395 400

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

405 410 415

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Val?Ser

420 425 430

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

435 440 445

Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

450 455 460

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

465 470 475 480

Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

485 490 495

Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

500 505 510

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Gly?Ser

515 520 525

Ala?Ser?Thr?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

530 535 540

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Ile?Ser?Ala?Ser?Glu?Ser

545 550 555 560

Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Thr?Ser?Ala?Ser

565 570 575

Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

580 585 590

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser

595 600 605

Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser

610 615 620

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

625 630 635 640

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

645 650 655

Thr?Ser?Ala?Ser?Val?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

660 665 670

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser

675 680 685

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

690 695 700

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser

705 710 715 720

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser

725 730 735

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

740 745 750

Thr?Ser?Ala?Ser?Gly?Ser?Ala?Ser?Thr?Ser?Thr?Ser?Ala?Ser?Ala?Ser

755 760 765

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

770 775 780

Ile?Ser?Ala?Ser?Glu?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser

785 790 795 800

Thr?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Glu?Ser?Ala?Ser

805 810 815

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser?Thr?Ser?Ala?Ser?Ala?Ser?Ala?Ser

820 825 830

Thr?Ser?Ala?Ser?Ala?Ser?Ala?Arg?Gln?Val?Arg?Arg?Pro?Gln?Pro?Val

835 840 845

His?Leu?Asn?Arg?His?Gln?Pro?Val?Arg?Gln?Pro?Gln?Gln?Val?Leu?Val

850 855 860

His?Gln?Leu?Gln?His?Gln?Arg?Val?His?Arg?Leu?Gln?His?Gln?Pro?Val

865 870 875 880

Pro?Arg?Leu?Gln?Arg?Gln?Pro?Val?Arg?Gln?Leu?Gln?Gln?Val?Pro?Val

885 890 895

Leu?Gln?Ser?Gln?His?Gln?Gln?Val?Leu?Gln?Pro?Gln?His?Arg?Gln?Val

900 905 910

Pro?Arg?Leu?Gln?Gln?Ala?His?Gln?His?Leu?Asn?Gln?Arg?Arg?Gln?Ala

915 920 925

Pro?Gln?Leu?Gln?Gln?Val?Pro?Val?Arg?Gln?Pro?Gln?Arg?Arg?Gln?Val

930 935 940

Arg?Gln?Pro?Gln?Gln?Val?Leu?Val?His?Gln?Leu?Gln?His?Gln?Arg?Val

945 950 955 960

His?Arg?Leu?Arg?Arg?Gln?Pro?Val?His?Gln?Ser?Gln?Gln?Val?Pro?Val

965 970 975

Arg?Gln?Leu?Pro?His?Gln?Gln?Val?Pro?Arg?Leu?Gln?Gln?Ala?Pro?Val

980 985 990

Arg?Arg?Leu?Gln?Gln?Val?Leu?Ala?Pro?Gln?Pro?Gln?Pro?Gln?Pro?Val

995 1000 1005

Arg?Gln?Pro?Gln?Gln?Val?Ser?Gln?Arg?Leu?Asn?Arg?His?Gln?Arg?Val

1010 1015 1020

Arg?Pro?Leu?Gln?Gln?Val?Leu?Ala?Pro?Gln?Pro?Gln?Arg?Gln?Gln?Val

1025 1030 1035 1040

His?Arg?Leu?Gln?Arg?Gln?Arg?Val?Arg?Leu?Asn?Arg?His?Gln?Arg?Val

1045 1050 1055

Arg?Pro?Leu?Gln?Gln?Val?Leu?Ala?Pro?Gln?Pro?Gln?Arg?Gln?Gln?Val

1060 1065 1070

His?Arg?Leu?Gln?His?Gln?Arg?Val?Arg?Pro?Leu?Gln?Gln?Val?Leu?Ala

1075 1080 1085

Pro?Gln?Pro?Gln?Arg?Gln?Gln?Val?His?Arg?Leu?Gln?Arg?Gln?Arg?Val

1090 1095 1100

Arg?Leu?Ser?Gln?His?Gln?Arg?Val?Arg?Gln?Pro?Gln?Gln?Ala?His?Gln

1105 1110 1115 1120

Leu?Leu?Asn?Leu?His?Gln?Pro?Val?Arg?Gln?Pro?Gln?His?Arg?Gln?Ala

1125 1130 1135

Pro?Gln?Leu?Gln?Gln?Val?Pro?Val?Arg?Gln?Pro?Gln?Arg?Arg?Gln?Val

1140 1145 1150

Arg?Arg?Leu?Gln?Gln?Val?Pro?Val?Arg?Gln?Pro?Gln?Gln?Val?Pro?Val

1155 1160 1165

Arg?Gln?Pro?Gln?Arg?Arg?Gln?Val?Arg?Arg?Pro?Gln?Pro?Val?His?Leu

1170 1175 1180

Asn?Arg?His?Gln?Pro?Val?Arg?Gln?Pro?Gln?Gln?Val?Leu?Val?His?Gln

1185 1190 1195 1200

Leu?Gln?His?Gln?Arg?Val?His?Arg?Leu?Gln?His?Gln?Pro?Val?His?Gln

1205 1210 1215

Ser?Gln?Gln?Val?Pro?Val?Arg?Gln?Phe?Arg?Ile?Asn?Lys?Cys?Leu?Gly

1220 1225 1230

Phe?Ser?Lys?Tyr

1235

<210>110

<211>449

<212>PRT

＜213〉streptococcus pneumoniae

<400>110

Met?Gly?Val?Glu?Thr?Trp?Phe?Tyr?Ser?Ser?Ile?Cys?Trp?Leu?Ala?Ile

1 5 10 15

Gly?Leu?Gly?Ser?Val?Trp?Lys?Phe?Pro?Tyr?Met?Thr?Ala?Ala?Asn?Gly

20 25 30

Gly?Gly?Gly?Phe?Leu?Leu?Ile?Phe?LeuIle?Ser?Thr?Ile?Leu?Ile?Gly

35 40 45

Phe?Pro?Leu?Leu?Leu?Ala?Glu?Phe?Ala?Leu?Gly?Arg?Ser?Ala?Gly?Val

50 55 60

Ser?Ala?Ile?Lys?Thr?Phe?Gly?Lys?Leu?Gly?Lys?Asn?Asn?Lys?Tyr?Asn

65 70 75 80

Phe?Ile?Gly?Trp?Ile?Gly?Ala?Phe?Ala?Leu?Phe?Ile?Leu?Leu?Ser?Phe

85 90 95

Tyr?Ser?Val Ile?Gly?Gly?Trp?Ile?Leu?Val?Tyr?Leu?Gly?Ile?Glu?Phe

100 105 110

Gly?Lys?Leu?Phe?Gln?Leu?Gly?Gly?Thr?Gly?Asp?Tyr?Ala?Gln?Leu?Phe

115 120 125

Thr?Ser?Ile?Ile?Ser?Asn?Pro?Ala?Ile?Ala?Leu?Gly?Ala?Gln?Ala?Ala

130 135 140

Phe?Ile?Leu?Leu?Asn?Ile?Phe?Ile?Val?Ser?Arg?Gly?Val?Gln?Lys?Gly

145 150 155 160

Ile?Glu?Arg?Ala?Ser?Lys?Val?Met?Met?Pro?Leu?Leu?Phe?Ile?Val?Phe

165 170 175

Val?Phe?Ile?Ile?Gly?Arg?Ser?Leu?Ser?Leu?Pro?Asn?Ala?Met?Glu?Gly

180 185 190

Val?Leu?Tyr?Phe?Leu?Lys?Pro?Asp?Phe?Ser?Lys?Leu?Thr?Ser?Thr?Gly

195 200 205

Leu?Leu?Tyr?Ala?Leu?Gly?Gln?Ser?Phe?Phe?Ala?Leu?Ser?Leu?Gly?Val

210 215 220

Thr?Val?Met?Leu?Thr?Tyr?Ala?Ser?Tyr?Leu?Asp?Lys?Lys?Thr?Asn?Leu

225 230 235 240

Val?Gln?Ser?Gly?Ile?Ser?Ile?Val?Ala?Met?Asn?Ile?Ser?Ile?Ser?Ile

245 250 255

Met?Ala?Gly?Leu?Ala?Ile?Phe?Gln?Ala?Arg?Ser?Pro?Phe?Asn?Ile?Gln

260 265 270

Ser?Glu?Gly?Gly?Pro?Ser?Leu?Leu?PheIle?Val?Leu?Pro?Gln?Leu?Phe

275 280 285

Asp?Lys?Met?Pro?Phe?Gly?Thr?Ile?Phe?Tyr?Val?Leu?Phe?Leu?Leu?Leu

290 295 300

Phe?Leu?Phe?Ala?Thr?Val?Thr?Phe?Ser?Val?Val?Met?Leu?Glu?Ile?Asn

305 310 315 320

Val?Asp?Asn?Ile?Thr?Asn?Gln?Asp?Asn?Ser?Lys?Arg?Ala?Lys?Trp?Ser

325 330 335

Val?Ile?Leu?Gly?Ile?Leu?Thr?Phe?Val?Phe?Gly?Ile?Pro?Ser?Ala?Leu

340 345 350

Ser?Tyr?Gly?Val?Met?Ala?Asp?Val?His?Ile?Phe?Gly?Lys?Thr?Phe?Phe

355 360 365

Asp?Ala?Met?Asp?Phe?Leu?Val?Ser?Asn?Leu?Leu?Met?Pro?Phe?Gly?Ala

370 375 380

Leu?Tyr?Leu?Ser?Leu?Phe?Thr?Gly?Tyr?Ile?Phe?Lys?Lys?Ala?Leu?Ala

385 390 395 400

Met?Glu?Glu?Leu?His?Leu?Asp?Glu?Arg?Ala?Trp?Lys?Gln?Gly?Leu?Phe

405 410 415

Gln?Val?Trp?Leu?Phe?Leu?Leu?Arg?Phe?Phe?Val?Ser?Ser?Phe?Gln?Ser

420 425 430

Ser?Ser?Leu?Trp?Ser?Ser?Leu?Pro?Asn?Leu?Cys?Asn?Gln?Lys?Gly?Leu

435 440 445

Glu

<210>111

<211>186

<212>PRT

＜213〉streptococcus pneumoniae

<400>111

Met?Leu?Lys?Lys?Trp?Gln?Leu?Lys?Asp?Val?Ile?Leu?Leu?Ala?Phe?Leu

1 5 10 15

Ser?Ile?Phe?Phe?Gly?Gly?Val?Phe?Val?Gly?Ser?Gly?Tyr?Val?Tyr?Asn

20 25 30

Ile?Leu?Ser?Leu?Leu?Leu?Thr?Pro?Leu?Gly?Leu?Gln?Ala?Phe?Ala?Asn

35 40 45

Glu?Ile?Leu?Phe?Gly?Leu?Trp?Cys?Met?Ala?Ala?Pro?Ile?Ala?Ala?Ile

50 55 60

Phe?Val?Pro?Arg?Val?Gly?Ser?Ala?Thr?Ile?Gly?Glu?Val?Leu?Ala?Ala

65 70 75 80

Leu?Ala?Glu?Val?Leu?Tyr?Gly?Ser?Gln?Phe?Gly?Leu?Gly?Ala?Leu?Leu

85 90 95

Ser?Gly?Phe?Val?Gln?Gly?Leu?Gly?Ser?Glu?Phe?Gly?Phe?Ile?Val?Thr

100 105 110

Lys?Asn?Arg?Tyr?Glu?Ser?Trp?Leu?Ser?Leu?Thr?Ala?Asn?Ser?Ile?Gly

115 120 125

Ile?Thr?Leu?Val?Ser?Phe?Val?Tyr?Glu?Tyr?Ile?Lys?Leu?Gly?Tyr?Tyr

130 135 140

Ala?Phe?Ser?Leu?Pro?Phe?Val?Leu?Ser?Leu?Leu?Val?Val?Arg?Phe?Ile

145 150 155 160

Ser?Val?Tyr?Phe?Phe?Cys?Thr?Ile?Leu?Val?Arg?Ala?Ile?Val?Lys?Leu

165 170 175

Tyr?His?Gln?Phe?Ala?Thr?Gly?Gly?Lys?Ala

180 185

<210>112

<211>216

<212>PRT

＜213〉streptococcus pneumoniae

<400>112

Met?Val?Lys?Val?Ala?Thr?Gln?Thr?Pro?Ile?Ile?Ser?Leu?Phe?Leu?Leu

1 5 10 15

Ile?Leu?Ser?Leu?Glu?Thr?Ser?Phe?Ile?Pro?Ser?Ile?Ala?Leu?Thr?Leu

20 25 30

Ser?Val?Val?Ala?Phe?Cys?Ile?Leu?Phe?Met?Leu?Tyr?Tyr?Arg?Arg?Phe

35 40 45

Lys?Met?Leu?Ala?Trp?Met?Ile?Ile?Leu?Ala?Ile?Leu?Pro?Ser?Phe?Ala

50 55 60

Asn?Tyr?Trp?Ala?Val?Gln?Leu?His?Gly?Asp?Ala?Ser?Gln?Ala?Val?Met

65 70 75 80

Leu?Gly?Thr?Arg?Ala?Phe?Val?Thr?Val?Cys?Ile?Gly?Leu?Val?Phe?Val

85 90 95

Ser?Ser?Val?Ser?Leu?Lys?Glu?Leu?Leu?Leu?Tyr?Leu?Ala?Gln?Lys?Gly

100 105 110

Leu?Ser?Arg?Ser?Trp?Ser?Tyr?Ala?Leu?Ile?Val?Val?Phe?Asn?Ser?Phe

115 120 125

Pro?Leu?Ile?Gln?Gln?Glu?Ile?Lys?Ser?Leu?Lys?Glu?Ala?Cys?Leu?Leu

130 135 140

Arg?Gly?Gln?Glu?Leu?His?Phe?Trp?Ser?Pro?Leu?Ile?Tyr?Ser?Lys?Val

145 150 155 160

Leu?Met?Thr?Val?Phe?Arg?Trp?Arg?His?Leu?Tyr?Leu?Arg?Ala?Leu?Ser

165 170 175

Ala?His?Gly?Tyr?Asp?Glu?His?Ala?Gln?Leu?Lys?Asn?Ser?Tyr?Arg?Thr

180 185 190

Phe?Tyr?Ile?Pro?Lys?Lys?Thr?Lys?Leu?Ile?Tyr?Leu?Leu?Phe?Phe?Leu

195 200 205

Leu?Leu?Gln?Thr?Ser?Leu?Phe?Leu

210 215

<210>113

<211>174

<212>PRT

＜213〉streptococcus pneumoniae

<400>113

Met?Arg?Lys?His?Gln?Leu?Gln?Val?His?Lys?Leu?Thr?Ile?Leu?Ser?Met

1 5 10 15

Met?Ile?Ala?Leu?Asp?Val?Val?Leu?Thr?Pro?Ile?Phe?Arg?Ile?Glu?Gly

20 25 30

Met?Ala?Pro?Met?Ser?Ser?Val?Val?Asn?Ile?Leu?Ala?Gly?Ile?Met?Met

35 40 45

Gly?Pro?Val?Tyr?Ala?Leu?Ala?Met?Ala?Thr?Val?Thr?Ala?Phe?Ile?Arg

50 55 60

Met?Thr?Thr?Gln?Gly?Ile?Pro?Pro?Leu?Ala?Leu?Thr?Gly?Ala?Thr?Phe

65 70 75 80

Gly?Ala?Leu?Leu?Ala?Gly?Leu?Phe?Tyr?Lys?Tyr?Gly?Arg?Lys?Phe?His

85 90 95

Tyr?Ser?Ala?Leu?Gly?Glu?Ile?Leu?Gly?Thr?Gly?Ile?Ile?Gly?Ser?Ile

100 105 110

Val?Ser?Tyr?Pro?Val?Met?Val?Leu?Phe?Thr?Gly?Ser?Ala?Ala?Lys?Leu

115 120 125

Ser?Trp?Phe?Ile?Tyr?Thr?Pro?Arg?Phe?Phe?Gly?Ala?Thr?Leu?Ile?Gly

130 135 140

Thr?Ala?Ile?Ser?Phe?Ile?Ala?Phe?Arg?Phe?Leu?Ile?Lys?Gln?Glu?Phe

145 150 155 160

Phe?Lys?Lys?Val?Gln?Gly?Tyr?Phe?Phe?Ser?Glu?Arg?Ile?Asp

165 170

<210>114

<211>267

<212>PRT

＜213〉streptococcus pneumoniae

<400>114

Met?Gln?Glu?Phe?Thr?Asn?Pro?Phe?Pro?Ile?Gly?Ser?Ser?Ser?Leu?Ile

1 5 10 15

His?Cys?Ile?Thr?Asn?Glu?Ile?Ser?Cys?Glu?Met?Leu?Ala?Asn?Gly?Ile

20 25 30

Leu?Ala?Leu?Gly?Cys?Lys?Pro?Val?Met?Ala?Asp?Asp?Ser?Arg?Glu?Val

35 40 45

Leu?Asp?Phe?Thr?Lys?Gln?Ser?Gln?Ala?Leu?Phe?Ile?Asn?Leu?Gly?His

50 55 60

Leu?Ser?Ala?Glu?Lys?Glu?Lys?Ala?Ile?Arg?Met?Ala?Ala?Ser?Tyr?Ala

65 70 75 80

Asn?Gln?Ser?Ser?Leu?Pro?Met?Val?Val?Asp?Ala?Val?Gly?Val?Thr?Thr

85 90 95

Ser?Ser?Ile?Arg?Lys?Ser?Leu?Val?Lys?Asp?Leu?Leu?Asp?Tyr?Arg?Pro

100 105 110

Thr?Val?Leu?Lys?Gly?Asn?Met?Ser?Glu?Ile?Arg?Ser?Leu?Val?Gly?Leu

115 120 125

Lys?His?His?Gly?Val?Gly?Val?Asp?Ala?Ser?Ala?Lys?Asp?Gln?Glu?Thr

130 135 140

Glu?Asp?Leu?Leu?Gln?Val?Leu?Lys?Asp?Trp?Cys?Gln?Thr?Tyr?Pro?Gly

145 150 155 160

Met?Ser?Phe?Leu?Val?Thr?Gly?Pro?Lys?Asp?Leu?Val?Val?Ser?Lys?Asn

165 170 175

Gln?Val?Ala?Val?Leu?Gly?Asn?Gly?Cys?Thr?Glu?Leu?Asp?Trp?Ile?Thr

180 185 190

Gly?Thr?Gly?Asp?Leu?Val?Gly?Ala?Leu?Thr?Ala?Val?Phe?Leu?Ser?Gln

195 200 205

Gly?Lys?Thr?Gly?Phe?Glu?Ala?Ser?Cys?Leu?Ala?Val?Ser?Tyr?Leu?Asn

210 215 220

Ile?Ala?Ala?Glu?Lys?Ile?Val?Val?Gln?Gly?Met?Gly?Leu?Glu?Glu?Phe

225 230 235 240

Arg?Tyr?Gln?Val?Leu?Asn?Gln?Leu?Ser?Leu?Leu?Arg?Arg?Asp?Glu?Asn

245 250 255

Trp?Leu?Asp?Thr?Ile?Lys?Gly?Glu?Val?Tyr?Glu

260 265

<210>115

<211>277

<212>PRT

＜213〉streptococcus pneumoniae

<400>115

Met?Asn?His?Lys?Ile?Ala?Ile?Leu?Ser?Asp?Val?His?Gly?Asn?Ala?Thr

1 5 10 15

Ala?Leu?Glu?Ala?Val?Ile?Ala?Asp?Ala?Lys?Asn?Gln?Gly?Ala?Ser?Glu

20 25 30

Tyr?Trp?Leu?Leu?Gly?Asp?Ile?Phe?Leu?Pro?Gly?Pro?Gly?Ala?Asn?Asp

35 40 45

Leu?Val?Ala?Leu?Leu?Lys?Asp?Leu?Pro?Ile?Thr?Ala?Ser?Val?Arg?Gly

50 55 60

Asn?Trp?Asp?Asp?Arg?Val?Leu?Glu?Ala?Leu?Asp?Gly?Gln?Tyr?Gly?Leu

65 70 75 80

Glu?Asp?Pro?Gln?Glu?Val?Gln?Leu?Leu?Arg?Met?Thr?Gln?Tyr?Leu?Met

85 90 95

Glu?Arg?Met?Asp?Pro?Ala?Thr?Ile?Val?Trp?Leu?Arg?Ser?Leu?Pro?Leu

100 105 110

Leu?Glu?Lys?Lys?Glu?Ile?Asp?Gly?Leu?Arg?Phe?Ser?Ile?Ser?His?Asn

115 120 125

Leu?Pro?Asp?Lys?Asn?Tyr?Gly?Gly?Asp?Leu?Leu?Val?Glu?Asn?Asp?Thr

130 135 140

Glu?Lys?Phe?Asp?Gln?Leu?Leu?Asp?Ala?Glu?Thr?Asp?Val?Ala?Val?Tyr

145 150 155 160

Gly?His?Val?His?Lys?Gln?Leu?Leu?Arg?Tyr?Gly?Ser?Gln?Gly?Gln?Gln

165 170 175

Ile?Ile?Asn?Pro?Gly?Ser?Ile?Gly?Met?Pro?Tyr?Phe?Asn?Trp?Glu?Ala

180 185 190

Leu?Lys?Asn?His?Arg?Ser?Gln?Tyr?Ala?Val?Ile?Glu?Val?Glu?Asp?Gly

195 200 205

Glu?Leu?Leu?Asn?Ile?Gln?Phe?Arg?Lys?Val?Ala?Tyr?Asp?Tyr?Glu?Ala

210 215 220

Glu?Leu?Glu?Leu?Ala?Lys?Ser?Lys?Gly?Leu?Pro?Phe?Ile?Glu?Met?Tyr

225 230 235 240

Glu?Glu?Leu?Arg?Arg?Asp?Asp?Asn?Tyr?Gln?Gly?His?Asn?Leu?Glu?Leu

245 250 255

Leu?Ala?Ser?Leu?Ile?Glu?Lys?His?Gly?Tyr?Val?Glu?Asp?Val?Lys?Asn

260 265 270

Phe?Phe?Asp?Phe?Leu

275

<210>116

<211>241

<212>PRT

＜213〉streptococcus pneumoniae

<400>116

Met?Asn?Val?Asn?Gln?Ile?Val?Arg?Ile?Ile?Pro?Thr?Leu?Lys?Ala?Asn

1 5 10 15

Asn?Arg?Lys?Leu?Asn?Glu?Thr?Phe?Tyr?Ile?Glu?Thr?Leu?Gly?Met?Lys

20 25 30

Ala?Leu?Leu?Glu?Glu?Ser?Ala?Phe?Leu?Ser?Leu?Gly?Asp?Gln?Thr?Gly

35 40 45

Leu?Glu?Lys?Leu?Val?Leu?Glu?Glu?Ala?Pro?Ser?Met?Arg?Thr?Arg?Lys

50 55 60

Val?Glu?Gly?Arg?Lys?Lys?Leu?Ala?Arg?Leu?Ile?Val?Lys?Val?Glu?Asn

65 70 75 80

Pro?Leu?Glu?Ile?Glu?Gly?Ile?Leu?Ser?Lys?Thr?Asp?Ser?Ile?His?Arg

85 90 95

Leu?Tyr?Lys?Gly?Gln?Asn?Gly?Tyr?Ala?Phe?Glu?Ile?Phe?Ser?Pro?Glu

100 105 110

Asp?Asp?Leu?Ile?Leu?Ile?His?Ala?Glu?Asp?Asp?Ile?Ala?Ser?Leu?Val

115 120 125

Glu?Val?Gly?Glu?Lys?Pro?Glu?Phe?Gln?Thr?Asp?Leu?Ala?Ser?Ile?Ser

130 135 140

Leu?Ser?Lys?Phe?Glu?Ile?Ser?Met?Glu?Leu?His?Leu?Pro?Thr?Asp?Ile

145 150 155 160

Glu?Ser?Phe?Leu?Glu?Ser?Ser?Glu?Ile?Gly?Ala?Ser?Leu?Asp?Phe?Ile

165 170 175

Pro?Ala?Gln?Gly?Gln?Asp?Leu?Thr?Val?Asp?Asn?Thr?Val?Thr?Trp?Asp

180 185 190

Leu?Ser?Met?Leu?Lys?Phe?Leu?Val?Asn?Glu?Leu?Asp?Ile?Ala?Ser?Leu

195 200 205

Arg?Gln?Lys?Phe?Glu?Ser?Thr?Glu?Tyr?Phe?Ile?Pro?Lys?Ser?Glu?Lys

210 215 220

Phe?Phe?Leu?Gly?Lys?Asp?Arg?Asn?Asn?Val?Glu?Leu?Trp?Phe?Glu?Glu

225 230 235 240

Val

<210>117

<211>311

<212>PRT

＜213〉streptococcus pneumoniae

<400>117

Met?Lys?Trp?Thr?Lys?Ile?Ile?Lys?Lys?Ile?Glu?Glu?Gln?Ile?Glu?Ala

1 5 10 15

Gly?Ile?Tyr?Pro?Gly?Ala?Ser?Phe?Ala?Tyr?Phe?Lys?Asp?Asn?Gln?Trp

20 25 30

Thr?Glu?Phe?Tyr?Leu?Gly?Gln?Ser?Asp?Pro?Glu?His?Gly?Leu?Gln?Thr

35 40 45

Glu?Ala?Gly?Leu?Val?Tyr?Asp?Leu?Ala?Ser?Val?Ser?Lys?Val?Val?Gly

50 55 60

Val?Gly?Thr?Val?Cys?Thr?Phe?Leu?Trp?Glu?Ile?Gly?Gln?Leu?Asp?Ile

65 70 75 80

Asp?Arg?Leu?Val?Ile?Asp?Phe?Leu?Pro?Glu?Ser?Asp?Tyr?Pro?Asp?Ile

85 90 95

Thr?Ile?Arg?Gln?Leu?Leu?Thr?His?Ala?Thr?Asp?Leu?Asp?Pro?Phe?Ile

100 105 110

Pro?Asn?Arg?Asp?Leu?Leu?Thr?Ala?Pro?Glu?Leu?Lys?Glu?Ala?Met?Phe

115 120 125

His?Leu?Asn?Arg?Arg?Ser?Gln?Pro?Ala?Phe?Leu?Tyr?Ser?Asp?Val?His

130 135 140

Phe?Leu?Leu?Leu?Gly?Phe?Ile?Leu?Glu?Arg?Ile?Phe?Asn?Gln?Asp?Leu

145 150 155 160

Asp?Val?Ile?Leu?Lys?Asp?Gln?Val?Trp?Lys?Pro?Trp?Gly?Met?Thr?Glu

165 170 175

Thr?Lys?Phe?Gly?Pro?Val?Glu?Leu?Ala?Val?Pro?Thr?Val?Arg?Gly?Val

180 185 190

Glu?Ala?Gly?Ile?Val?His?Asp?Pro?Lys?Ala?Arg?Leu?Leu?Gly?Arg?His

195 200 205

Ala?Gly?Ser?Ala?Gly?Leu?Phe?Ser?Thr?Ile?Lys?Asp?Leu?Gln?Ile?Phe

210 215 220

Leu?Glu?His?Tyr?Leu?Ala?Asp?Asp?Phe?Ala?Arg?Asp?Leu?Asn?Gln?Asn

225 230 235 240

Phe?Ser?Pro?Leu?Asp?Asp?Lys?Glu?Arg?Ser?Leu?Ala?Trp?Asn?Leu?Glu

245 250 255

Gly?Asp?Trp?Leu?Asp?His?Thr?Gly?Tyr?Thr?Gly?Thr?Phe?Ile?Met?Trp

260 265 270

Asn?Arg?Gln?Lys?Gln?Glu?Ala?Thr?Ile?Phe?Leu?Ser?Asn?Arg?Thr?Tyr

275 280 285

Glu?Lys?Asp?Glu?Arg?Ala?Gln?Trp?Ile?Leu?Asp?Arg?Asn?Gln?Val?Met

290 295 300

Asn?Leu?Ile?Arg?Lys?Glu?Glu

305 310

<210>118

<211>160

<212>PRT

＜213〉streptococcus pneumoniae

<400>118

Met?Met?Lys?Lys?Thr?Tyr?Asn?His?Ile?Leu?Val?Trp?Gly?Val?Ile?Phe

1 5 10 15

Tyr?Ser?Ile?Cys?Ile?Val?Cys?Phe?Cys?Phe?Thr?Pro?Gln?Glu?Gln?Ser

20 25 30

Thr?Val?Gly?Val?Gly?Thr?Pro?Gly?Ile?Gln?His?Leu?Gly?Arg?Leu?Val

35 40 45

Phe?Leu?Leu?Thr?Pro?Phe?Asn?Ser?Leu?Trp?Lys?Leu?Gly?Glu?Val?Ser

50 55 60

Asp?Ile?Gly?Gln?Leu?Cys?Trp?Ile?Phe?Leu?Gln?Asn?Ile?Leu?Asn?Val

65 70 75 80

Phe?Leu?Phe?Phe?Pro?Leu?Ile?Phe?Gln?Leu?Leu?Tyr?Leu?Phe?Pro?Asn

85 90 95

Leu?Arg?Lys?Thr?Lys?Lys?Val?Leu?Leu?Phe?Ser?Phe?Leu?Val?Ser?Leu

100 105 110

Gly?Ile?Glu?Cys?Thr?Gln?Leu?Ile?Leu?Asp?Phe?Phe?Phe?Asp?Phe?Asn

115 120 125

Arg?Val?Phe?Glu?Ile?Asp?Asp?Leu?Trp?Thr?Asn?Thr?Leu?Gly?Gly?Tyr

130 135 140

Leu?Ala?Trp?Leu?Leu?Tyr?Lys?Arg?Leu?His?Lys?Asn?Lys?Val?Arg?Asn

145 150 155 160

<210>119

<211>263

<212>PRT

＜213〉streptococcus pneumoniae

<400>119

Met?Lys?Ile?Pro?Leu?Leu?Thr?Phe?Ala?Arg?His?Lys?Phe?Val?Tyr?Val

1 5 10 15

Leu?Leu?Thr?Leu?Leu?Phe?Leu?Ala?Leu?Val?Tyr?Arg?Asp?Val?Leu?Met

20 25 30

Thr?Tyr?Phe?Phe?Phe?Asp?Ile?His?Ala?Pro?Asp?Leu?Ala?Lys?Phe?Asp

35 40 45

Gly?Gln?Ala?Ile?Lys?Asn?Asp?Leu?Leu?Lys?Ser?Ala?Leu?Asp?Phe?Arg

50 55 60

Ile?Leu?Gln?Phe?Asn?Leu?Gly?Phe?Tyr?Gln?Ser?Phe?Ile?Ile?Pro?Ile

65 70 75 80

Ile?Ile?Val?Leu?Leu?Gly?Phe?Gln?Tyr?Ile?Glu?Leu?Lys?Asn?Lys?Val

85 90 95

Leu?Arg?Leu?Ser?Ile?Gly?Arg?Glu?Val?Ser?Tyr?Gln?Gly?Leu?Lys?Arg

100 105 110

Lys?Leu?Thr?Leu?Gln?Val?Ala?Ser?Ile?Pro?Cys?Leu?Ile?Tyr?Leu?Val

115 120 125

Thr?Val?Leu?IleIle?Ala?Ile?Ile?Thr?Tyr?Phe?Phe?Gly?Thr?Phe?Ser

130 135 140

Pro?Leu?Gly?Trp?Asn?Ser?Leu?Phe?Ser?Asp?Gly?Ser?Gly?Leu?Gln?Arg

145 150 155 160

Leu?Leu?Asp?Gly?Glu?Ile?Lys?Ser?Tyr?Leu?Phe?Phe?Thr?Cys?Val?Leu

165 170 175

Leu?Ile?Gly?Ile?PheIle?Asn?Ala?Ile?Tyr?Phe?Leu?Gln?Ile?Val?Asp

180 185 190

Tyr?Val?Gly?Asn?Val?Thr?Arg?Ser?Ala?Ile?Thr?Tyr?Leu?Met?Phe?Leu

195 200 205

Trp?Leu?Gly?Ser?Met?Leu?Leu?Tyr?Ser?Ala?Leu?Pro?Tyr?Tyr?Met?Val

210 215 220

Pro?Met?Thr?Ser?Leu?Met?Gln?Ala?Ser?Tyr?Gly?Asp?Val?Ser?Leu?Met

225 230 235 240

Lys?Leu?Phe?Thr?Pro?Tyr?Ile?Leu?Tyr?Ile?Val?Pro?Tyr?Met?Val?Leu

245 250 255

Glu?Lys?Tyr?Glu?Asp?Asn?Val

260

<210>120

<211>505

<212>PRT

＜213〉streptococcus pneumoniae

<400>120

Met?Phe?Lys?Val?Leu?Gln?Lys?Val?Gly?Lys?Ala?Phe?Met?Leu?Pro?Ile

1 5 10 15

Ala?Ile?Leu?Pro?Ala?Ala?Gly?Leu?Leu?Leu?Gly?Ile?Gly?Gly?Ala?Leu

20 25 30

Ser?Asn?Pro?Thr?Thr?Ile?Ala?Thr?Tyr?Pro?Ile?Leu?Asp?Asn?Ser?Ile

35 40 45

Phe?Gln?Ser?Ile?Phe?Gln?Val?Met?Ser?Ser?Ala?Gly?Glu?Val?Val?Phe

50 55 60

Ser?Asn?Leu?Ser?Leu?Leu?Leu?Cys?Val?Gly?Leu?Cys?Ile?Gly?Leu?Ala

65 70 75 80

Lys?Arg?Asp?Lys?Gly?Thr?Ala?Ala?Leu?Ala?Gly?Val?Thr?Gly?Tyr?Leu

85 90 95

Val?Met?Thr?Ala?Thr?Ile?Lys?Ala?Leu?Val?Lys?Leu?Phe?Met?Ala?Glu

100 105 110

Gly?Ser?Ala?Ile?Asp?Thr?Gly?Val?Ile?Gly?Ala?Leu?Val?Val?Gly?Ile

115 120 125

Val?Ala?Val?Tyr?Leu?His?Asn?Arg?Tyr?Asn?Asn?Ile?Gln?Leu?Pro?Ser

130 135 140

Ala?Leu?Gly?Phe?Phe?Gly?Gly?Ser?Arg?Phe?Val?Pro?Ile?Val?Thr?Ser

145 150 155 160

Phe?Ser?Ser?Ile?Leu?Ile?Gly?Phe?Val?Phe?Phe?Val?Ile?Trp?Pro?Pro

165 170 175

Phe?Gln?Gln?Leu?Leu?Val?Ser?Thr?Gly?Gly?Tyr?Ile?Ser?Gln?Ala?Gly

180 185 190

Pro?Ile?Gly?Thr?Phe?Leu?Tyr?Gly?Phe?Leu?Met?Arg?Leu?Ser?Gly?Ala

195 200 205

Val?Gly?Leu?His?His?Ile?Ile?Tyr?Pro?Met?Phe?Trp?Tyr?Thr?Glu?Leu

210 215 220

Gly?Gly?Val?Glu?Thr?Val?Ala?Gly?Gln?Thr?Val?Val?Gly?Ala?Gln?Lys

225 230 235 240

Ile?Phe?Phe?Ala?Gln?Leu?Ala?Asp?Leu?Ala?His?Ser?Gly?Leu?Phe?Thr

245 250 255

Glu?Gly?Thr?Arg?Phe?Phe?Ala?Gly?Arg?Phe?Ser?Thr?Met?Met?Phe?Gly

260 265 270

Leu?Pro?Ala?Ala?Cys?Leu?Ala?Met?Tyr?His?Ser?Val?Pro?Lys?Asn?Arg

275 280 285

Arg?Lys?Lys?Tyr?Ala?Gly?Leu?Phe?Phe?Gly?Val?Ala?Leu?Thr?Ser?Phe

290 295 300

Ile?Thr?Gly?Ile?Thr?Glu?Pro?Ile?Glu?Phe?Met?Phe?Leu?Phe?Val?Ser

305 310 315 320

Pro?Val?Leu?Tyr?Val?Val?His?Ala?Phe?Leu?Asp?Gly?Val?Ser?Phe?Phe

325 330 335

Ile?Ala?Asp?Val?Leu?Asn?Ile?Ser?Ile?Gly?Asn?Thr?Phe?Ser?Gly?Gly

340 345 350

Val?Ile?Asp?Phe?Thr?Leu?Phe?Gly?Ile?Leu?Gln?Gly?Asn?Ala?Lys?Thr

355 360 365

Asn?Trp?Val?Leu?Gln?Ile?Pro?Phe?Gly?Leu?Ile?Trp?Ser?Val?Leu?Tyr

370 375 380

Tyr?Ile?Ile?Phe?Arg?Trp?Phe?Ile?Thr?Gln?Phe?Asn?Val?Leu?Thr?Pro

385 390 395 400

Gly?Arg?Gly?Glu?Glu?Val?Asp?Ser?Lys?Glu?Ile?Ser?Glu?Ser?Ala?Asp

405 410 415

Ser?Thr?Ser?Asn?Thr?Ala?Asp?Tyr?Leu?Lys?Gln?Asp?Ser?Leu?Gln?Ile

420 425 430

Ile?Arg?Ala?Leu?Gly?Gly?Ser?Asn?Asn?Ile?Glu?Asp?Val?Asp?Ala?Cys

435 440 445

Val?Thr?Arg?Leu?Arg?Val?Ala?Val?Lys?Glu?Val?Asn?Gln?Val?Asp?Lys

450 455 460

Ala?Leu?Leu?Lys?Gln?Ile?Gly?Ala?Val?Asp?Val?Leu?Glu?Val?Lys?Gly

465 470 475 480

Gly?Ile?Gln?Ala?Ile?Tyr?Gly?Ala?Lys?Ala?Ile?Leu?Tyr?Lys?Asn?Ser

485 490 495

Ile?Asn?Glu?Ile?Leu?Gly?Val?Asp?Asp

500 505

<210>121

<211>442

<212>PRT

＜213〉streptococcus pneumoniae

<400>121

Met?Lys?Phe?Arg?Lys?Leu?Ala?Cys?Thr?Val?Leu?Ala?Gly?Ala?Ala?Val

1 5 10 15

Leu?Gly?Leu?Ala?Ala?Cys?Gly?Asn?Ser?Gly?Gly?Ser?Lys?Asp?Ala?Ala

20 25 30

Lys?Ser?Gly?Gly?Asp?Gly?Ala?Lys?Thr?Glu?Ile?Thr?Trp?Trp?Ala?Phe

35 40 45

Pro?Val?Phe?Thr?Gln?Glu?Lys?Thr?Gly?Asp?Gly?Val?Gly?Thr?Tyr?Glu

50 55 60

Lys?Ser?Ile?Ile?Glu?Ala?Phe?Glu?Lys?Ala?Asn?Pro?Asp?Ile?Lys?Val

65 70 75 80

Lys?Leu?Glu?Thr?Ile?Asp?Phe?Lys?Ser?Gly?Pro?Glu?Lys?Ile?Thr?Thr

85 90 95

Ala?Ile?Glu?Ala?Gly?Thr?Ala?Pro?Asp?Val?Leu?Phe?Asp?Ala?Pro?Gly

100 105 110

Arg?Ile?Ile?Gln?Tyr?Gly?Lys?Asn?Gly?Lys?Leu?Ala?Glu?Leu?Asn?Asp

115 120 125

Leu?Phe?Thr?Asp?Glu?Phe?Val?Lys?Asp?Val?Asn?Asn?Glu?Asn?Ile?Val

130 135 140

Gln?Ala?Ser?Lys?Ala?Gly?Asp?Lys?Ala?Tyr?Met?Tyr?Pro?Ile?Ser?Ser

145 150 155 160

Ala?Pro?Phe?Tyr?Met?Ala?Met?Asn?Lys?Lys?Met?Leu?Glu?Asp?Ala?Gly

165 170 175

Val?Ala?Asn?Leu?Val?Lys?Glu?Gly?Trp?Thr?Thr?Asp?Asp?Phe?Glu?Lys

180 185 190

Val?Leu?Lys?Ala?Leu?Lys?Asp?Lys?Gly?Tyr?Thr?Pro?Gly?Ser?Leu?Phe

195 200 205

Ser?Ser?Gly?Gln?Gly?Gly?Asp?Gln?Gly?Thr?Arg?Ala?Phe?Ile?Ser?Asn

210 215 220

Leu?Tyr?Ser?Gly?Ser?Val?Thr?Asp?Glu?Lys?Val?Ser?Lys?Tyr?Thr?Thr

225 230 235 240

Asp?Asp?Pro?Lys?Phe?Val?Lys?Gly?Leu?Glu?Lys?Ala?Thr?Ser?Trp?Ile

245 250 255

Lys?Asp?Asn?Leu?Ile?Asn?Asn?Gly?Ser?Gln?Phe?Asp?Gly?Gly?Ala?Asp

260 265 270

Ile?Gln?Asn?Phe?Ala?Asn?Gly?Gln?Thr?Ser?Tyr?Thr?Ile?Leu?Trp?Ala

275 280 285

Pro?Ala?Gln?Asn?Gly?Ile?Gln?Ala?Lys?Leu?Leu?Glu?Ala?Ser?Lys?Val

290 295 300

Glu?Val?Val?Glu?Val?Pro?Phe?Pro?Ser?Asp?Glu?Gly?Lys?Pro?Ala?Leu

305 310 315 320

Glu?Tyr?Leu?Val?Asn?Gly?Phe?Ala?Val?Phe?Asn?Asn?Lys?Asp?Asp?Lys

325 330 335

Lys?Val?Ala?Ala?Ser?Lys?Lys?Phe?Ile?Gln?Phe?Ile?Ala?Asp?Asp?Lys

340 345 350

Glu?Trp?Gly?Pro?Lys?Asp?Val?Val?Arg?Thr?Gly?Ala?Phe?Pro?Val?Arg

355 360 365

Thr?Ser?Phe?Gly?Lys?Leu?Tyr?Glu?Asp?Lys?Arg?Met?Glu?Thr?Ile?Ser

370 375 380

Gly?Trp?Thr?Gln?Tyr?Tyr?Ser?Pro?Tyr?Tyr?Asn?Thr?Ile?Asp?Gly?Phe

385 390 395 400

Ala?Glu?Met?Arg?Thr?Leu?Trp?Phe?Pro?Met?Leu?Gln?Ser?Val?Ser?Asn

405 410 415

Gly?Asp?Glu?Lys?Pro?Ala?Asp?Ala?Leu?Lys?Ala?Phe?Thr?Glu?Lys?Ala

420 425 430

Asn?Glu?Thr?Ile?Lys?Lys?Ala?Met?Lys?Gln

435 440

<210>122

<211>279

<212>PRT

＜213〉streptococcus pneumoniae

<400>122

Met?Gln?Ser?Thr?Glu?Lys?Lys?Pro?Leu?Thr?Ala?Phe?Thr?Val?Ile?Ser

1 5 10 15

Thr?Ile?Ile?Leu?Leu?Leu?Leu?Thr?Val?Leu?Phe?Ile?Phe?Pro?Phe?Tyr

20 25 30

Trp?Ile?Leu?Thr?Gly?Ala?Phe?Lys?Ser?Gln?Pro?Asp?Thr?Ile?Val?Ile

35 40 45

Pro?Pro?Gln?Trp?Phe?Pro?Lys?Met?Pro?Thr?Met?Glu?Asn?Phe?Gln?Gln

50 55 60

Leu?Met?Val?Gln?Asn?Pro?Ala?Leu?Gln?Trp?Met?Trp?Asn?Ser?Val?Phe

65 70 75 80

Ile?Ser?Leu?Val?Thr?Met?Phe?Leu?Val?Cys?Ala?Thr?Ser?Ser?Leu?Ala

85 90 95

Gly?Tyr?Val?Leu?Ala?Lys?Lys?Arg?Phe?Tyr?Gly?Gln?Arg?Ile?Leu?Phe

100 105 110

Ala?Ile?Phe?Ile?Ala?Ala?Met?Ala?Leu?Pro?Lys?Gln?Val?Val?Leu?Val

115 120 125

Pro?Leu?Val?Arg?Ile?Val?Asn?Phe?Met?Gly?Ile?His?Asp?Thr?Leu?Trp

130 135 140

Ala?Val?Ile?Leu?Pro?Leu?Ile?Gly?Trp?Pro?Phe?Gly?Val?Phe?Leu?Met

145 150 155 160

Lys?Gln?Phe?Ser?Glu?Asn?Ile?Pro?Thr?Glu?Leu?Leu?Glu?Ser?Ala?Lys

165 170 175

Ile?Asp?Gly?Cys?Gly?Glu?Ile?Arg?Thr?Phe?Trp?Ser?Val?Ala?Phe?Pro

180 185 190

Ile?Val?Lys?Pro?Gly?Phe?Ala?Ala?Leu?Ala?Ile?Phe?Thr?Phe?Ile?Asn

195 200 205

Thr?Trp?Asn?Asp?Tyr?Phe?Met?Gln?Leu?Val?Met?Leu?Thr?Ser?Arg?Asn

210 215 220

Asn?Leu?Thr?Ile?Ser?Leu?Gly?Val?Ala?Thr?Met?Gln?Ala?Glu?Met?Ala

225 230 235 240

Thr?Asn?Tyr?Gly?Leu?Ile?Met?Ala?Gly?Ala?Ala?Leu?Ala?Ala?Val?Pro

245 250 255

Ile?Val?Thr?Val?Phe?Leu?Val?Phe?Gln?Lys?Ser?Phe?Thr?Gln?Gly?Ile

260 265 270

Thr?Met?Gly?Ala?Val?Lys?Gly

275

<210>123

<211>216

<212>PRT

＜213〉streptococcus pneumoniae

<400>123

Met?Lys?Ile?Met?Phe?Lys?Asn?Phe?Asn?Asn?Ile?Leu?Leu?Asn?Arg?Lys

1 5 10 15

Ile?Val?Leu?Leu?Leu?Arg?Ile?Val?Leu?Met?Met?Ile?Leu?Ile?Asn?His

20 25 30

Leu?Leu?Ser?Thr?Ala?Val?Gln?Lys?Gln?Asp?Ala?Val?Ile?Phe?Phe?Lys

35 40 45

Arg?Glu?Leu?Ile?Ser?Ile?Phe?Ser?Tyr?Asn?Asp?Tyr?Ser?Glu?Ala?Asn

50 55 60

Leu?Glu?Ile?Pro?Lys?Leu?Leu?Leu?Asn?Leu?Ser?Leu?Phe?Met?Val?Gly

65 70 75 80

Trp?Leu?Ser?Val?Ile?Leu?Leu?Glu?Ser?Asp?Leu?Ala?Asp?His?Tyr?His

85 90 95

His?Leu?Ile?Arg?Tyr?Gln?Ser?Ser?Ser?Phe?Phe?Asp?Tyr?Thr?Arg?Lys

100 105 110

Arg?Leu?Val?Val?Ile?Ser?Lys?Phe?Phe?Thr?Gln?Asp?Leu?Phe?Val?Trp

115 120 125

Phe?Leu?Gly?Leu?Leu?Pro?Leu?Gly?Ile?His?Phe?Lys?Thr?Val?Ala?Leu

130 135 140

Phe?Phe?Leu?Leu?Ala?Gln?Leu?Met?Met?Leu?Tyr?Leu?Leu?Leu?Ser?Tyr

145 150 155 160

Leu?Ile?Ala?Leu?Ile?Ser?Ala?Gly?Ala?Gly?Phe?Ser?Phe?Phe?Leu?Tyr

165 170 175

Phe?Leu?Ala?Phe?Val?Gly?Gln?Glu?Trp?Met?Met?Asp?His?Ile?Val?Thr

180 185 190

Val?Tyr?Leu?Val?Leu?Leu?Ser?Leu?Leu?Val?Met?Leu?Ile?Val?Ser?Arg

195 200 205

Leu?Glu?Glu?Lys?Phe?Lys?Lys?Gly

210 215

<210>124

<211>174

<212>PRT

＜213〉streptococcus pneumoniae

<400>124

Met?Gly?Lys?Gly?Glu?Met?Gly?Lys?Gly?Val?Ile?Gly?Leu?Glu?Phe?Asp

1 5 10 15

Ser?Glu?Val?Leu?Val?Asn?Lys?Ala?Pro?Thr?Leu?Gln?Leu?Ala?Asn?Gly

20 25 30

Lys?Thr?Ala?Thr?Phe?Leu?Thr?Gln?Tyr?Asp?Ser?Lys?Thr?Leu?Leu?Phe

35 40 45

Ala?Val?Asp?Lys?Glu?Asp?Ile?Gly?Gln?Glu?Ile?Ile?Gly?Ile?Ala?Lys

50 55 60

Gly?Ser?Ile?Glu?Ser?Met?His?Asn?Leu?Pro?Val?Asn?Leu?Ala?Gly?Ala

65 70 75 80

Arg?Val?Pro?Gly?Gly?Val?Asn?Gly?Ser?Lys?Ala?Ala?Val?His?Glu?Val

85 90 95

Pro?Glu?Phe?Thr?Gly?Gly?Val?Asn?Gly?Thr?Glu?Pro?Ala?Val?His?Glu

100 105 110

Ile?Ala?Glu?Tyr?Lys?Gly?Ser?Asp?Ser?Leu?Val?Thr?Leu?Thr?Thr?Lys

115 120 125

Lys?Asp?Tyr?Thr?Tyr?Lys?Ala?Pro?Leu?Ala?Gln?Gln?Ala?Leu?Pro?Glu

130 135 140

Thr?Gly?Asn?Lys?Glu?Ser?Asp?Leu?Leu?Ala?Ser?Leu?Gly?Leu?Thr?Ala

145 150 155 160

Phe?Phe?Leu?Gly?Leu?Phe?Thr?Leu?Gly?Lys?Lys?Arg?Glu?Gln

165 170

<210>125

<211>629

<212>PRT

＜213〉streptococcus pneumoniae

<400>125

Met?Lys?Lys?Thr?Phe?Phe?Leu?Leu?Val?Leu?Gly?Leu?Phe?Cys?Leu?Leu

1 5 10 15

Pro?Leu?Ser?Val?Phe?Ala?Ile?Asp?Phe?Lys?Ile?Asn?Ser?Tyr?Gln?Gly

20 25 30

Asp?Leu?Tyr?Ile?His?Ala?Asp?Asn?Thr?Ala?Glu?Phe?Arg?Gln?Lys?Ile

35 40 45

Val?Tyr?Gln?Phe?Glu?Glu?Asp?Phe?Lys?Gly?Gln?Ile?Val?Gly?Leu?Gly

50 55 60

Arg?Ala?Gly?Lys?Met?Pro?Ser?Gly?Phe?Asp?Ile?Asp?Pro?His?Pro?Lys

65 70 75 80

Ile?Gln?Ala?Ala?Lys?Asn?Gly?Ala?Glu?Leu?Ala?Asp?Val?Thr?Ser?Glu

85 90 95

Val?Thr?Glu?Glu?Ala?Asp?Gly?Tyr?Thr?Val?Arg?Val?Tyr?Asn?Pro?Gly

100 105 110

Gln?Glu?Gly?Asp?Ile?Val?Glu?Val?Asp?Leu?Val?Trp?Asn?Leu?Lys?Asn

115 120 125

Leu?Leu?Phe?Leu?Tyr?Asp?Asp?Ile?Ala?Glu?Leu?Asn?Trp?Gln?Pro?Leu

130 135 140

Thr?Asp?Ser?Ser?Glu?Ser?Ile?Glu?Lys?Phe?Glu?Phe?His?Val?Arg?Gly

145 150 155 160

Asp?Lys?Gly?Ala?Glu?Lys?Leu?Phe?Phe?His?Thr?Gly?Lys?Leu?Phe?Arg

165 170 175

Glu?Gly?Thr?Ile?Glu?Lys?Ser?Asn?Leu?Asp?Tyr?Thr?Ile?Arg?Leu?Asp

180 185 190

Asn?Leu?Pro?Ala?Lys?Arg?Gly?Val?Glu?Leu?His?Ala?Tyr?Trp?Pro?Arg

195 200 205

Thr?Asp?Phe?Ala?Ser?Ala?Arg?Asp?Gln?Gly?Leu?Lys?Gly?Asn?Arg?Leu

210 215 220

Glu?Glu?Phe?Asn?Lys?Ile?Glu?Asp?Ser?Ile?Val?Arg?Glu?Lys?Asp?Gln

225 230 235 240

Ser?Lys?Gln?Leu?Val?Thr?Trp?Val?Leu?Pro?Ser?Ile?Leu?Ser?Ile?Ser

245 250 255

Leu?Leu?Leu?Ser?Val?Cys?Phe?Tyr?Phe?Ile?Tyr?Arg?Arg?Lys?Thr?Thr

260 265 270

Pro?Ser?Val?Lys?Tyr?Ala?Lys?Asn?His?Arg?Leu?Tyr?Glu?Pro?Pro?Met

275 280 285

Glu?Leu?Glu?Pro?Met?Val?Leu?Ser?Glu?Ala?Val?Tyr?Ser?Thr?Ser?Leu

290 295 300

Glu?Glu?Val?Ser?Pro?Leu?Val?Lys?Gly?Ala?Gly?Lys?Phe?Thr?Phe?Asp

305 310 315 320

Gln?Leu?Ile?Gln?Ala?Thr?Leu?Leu?Asp?Val?Ile?Asp?Arg?Gly?Asn?Val

325 330 335

Ser?Ile?Ile?Ser?Glu?Gly?Asp?Ala?Val?Gly?Leu?Arg?Leu?Val?Lys?Glu

340 345 350

Asp?Gly?Leu?Ser?Ser?Phe?Glu?Lys?Asp?Cys?Leu?Asn?Leu?Ala?Phe?Ser

355 360 365

Gly?Lys?Lys?Glu?Glu?Thr?Leu?Ser?Asn?Leu?Phe?Ala?Asp?Tyr?Lys?Val

370 375 380

Ser?Asp?Ser?Leu?Tyr?Arg?Arg?Ala?Lys?Val?Ser?Asp?Glu?Lys?Arg?Ile

385 390 395 400

Gln?Ala?Arg?Gly?Leu?Gln?Leu?Lys?Ser?Ser?Phe?Glu?Glu?Val?Leu?Asn

405 410 415

Gln?Met?Gln?Glu?Gly?Val?Arg?Lys?Arg?Val?Ser?Phe?Trp?Gly?Leu?Pro

420 425 430

Asp?Tyr?Tyr?Arg?Pro?Leu?Thr?Gly?Gly?Glu?Lys?Ala?Leu?Gln?Val?Gly

435 440 445

Met?Gly?Ala?Leu?Thr?Ile?Leu?Pro?Leu?Phe?Ile?Gly?Phe?Gly?Leu?Phe

450 455 460

Leu?Tyr?Ser?Leu?Asp?Val?His?Gly?Tyr?Leu?Tyr?Leu?Pro?Leu?Pro?Ile

465 470 475 480

Leu?Gly?Phe?Leu?Gly?Leu?Val?Leu?Ser?Val?Phe?Tyr?Tyr?Trp?Lys?Leu

485 490 495

Arg?Leu?Asp?Asn?Arg?Asp?Gly?Val?Leu?Asn?Glu?Ala?Gly?Ala?Glu?Val

500 505 510

Tyr?Tyr?Leu?Trp?Thr?Ser?Phe?Glu?Asn?Met?Leu?Arg?Glu?Ile?Ala?Arg

515 520 525

Leu?Asp?Gln?Ala?Glu?Leu?Glu?Ser?Ile?Val?Val?Trp?Asn?Arg?Leu?Leu

530 535 540

Val?Tyr?Ala?Thr?Leu?Phe?Gly?Tyr?Ala?Asp?Lys?Val?Ser?His?Leu?Met

545 550 555 560

Lys?Val?His?Gln?Ile?Gln?Val?Glu?Asn?Pro?Asp?Ile?Asn?Leu?Tyr?Val

565 570 575

Ala?Tyr?Gly?Trp?His?Ser?Thr?Phe?Tyr?His?Ser?Thr?Ala?Gln?Met?Ser

580 585 590

His?Tyr?Ala?Ser?Val?Ala?Asn?Thr?Ala?Ser?Thr?Tyr?Ser?Val?Ser?Ser

595 600 605

Gly?Ser?Gly?Ser?Ser?Gly?Gly?Gly?Phe?Ser?Gly?Gly?Gly?Gly?Gly?Gly

610 615 620

Ser?Ile?Gly?Ala?Phe

625

<210>126

<211>886

<212>PRT

＜213〉streptococcus pneumoniae

<400>126

Met?Lys?Lys?Val?Arg?Lys?Ile?Phe?Gln?Lys?Ala?Val?Ala?Gly?Leu?Cys

1 5 10 15

Cys?Ile?Ser?Gln?Leu?Thr?Ala?Phe?Ser?Ser?Ile?Val?Ala?Leu?Ala?Glu

20 25 30

Thr?Pro?Glu?Thr?Ser?Pro?Ala?Ile?Gly?Lys?Val?Val?Ile?Lys?Glu?Thr

35 40 45

Gly?Glu?Gly?Gly?Ala?Leu?Leu?Gly?Asp?Ala?Val?Phe?Glu?Leu?Lys?Asn

50 55 60

Asn?Thr?Asp?Gly?Thr?Thr?Val?Ser?Gln?Arg?Thr?Glu?Ala?Gln?Thr?Gly

65 70 75 80

Glu?Ala?Ile?Phe?Ser?Asn?Ile?Lys?Pro?Gly?Thr?Tyr?Thr?Leu?Thr?Glu

85 90 95

Ala?Gln?Pro?Pro?Val?Gly?Tyr?Lys?Pro?Ser?Thr?Lys?Gln?Trp?Thr?Val

100 105 110

Glu?Val?Glu?Lys?Asn?Gly?Arg?Thr?Thr?Val?Gln?Gly?Glu?Gln?Val?Glu

115 120 125

Asn?Arg?Glu?Glu?Ala?Leu?Ser?Asp?Gln?Tyr?Pro?Gln?Thr?Gly?Thr?Tyr

130 135 140

Pro?Asp?Val?Gln?Thr?Pro?Tyr?Gln?Ile?Ile?Lys?Val?Asp?Gly?Ser?Glu

145 150 155 160

Lys?Asn?Gly?Gln?His?Lys?Ala?Leu?Asn?Pro?Asn?Pro?Tyr?Glu?Arg?Val

165 170 175

Ile?Pro?Glu?Gly?Thr?Leu?Ser?Lys?Arg?Ile?Tyr?Gln?Val?Asn?Asn?Leu

180 185 190

Asp?Asp?Asn?Gln?Tyr?Gly?Ile?Glu?Leu?Thr?Val?Ser?Gly?Lys?Thr?Val

195 200 205

Tyr?Glu?Gln?Lys?Asp?Lys?Ser?Val?Pro?Leu?Asp?Val?Val?Ile?Leu?Leu

210 215 220

Asp?Asn?Ser?Asn?Ser?Met?Ser?Asn?Ile?Arg?Asn?Lys?Asn?Ala?Arg?Arg

225 230 235 240

Ala?Glu?Arg?Ala?Gly?Glu?Ala?Thr?Arg?Ser?Leu?Ile?Asp?Lys?Ile?Thr

245 250 255

Ser?Asp?Ser?Glu?Asn?Arg?Val?Ala?Leu?Val?Thr?Tyr?Ala?Ser?Thr?Ile

260 265 270

Phe?Asp?Gly?Thr?Glu?Phe?Thr?Val?Glu?Lys?Gly?Val?Ala?Asp?Lys?Asn

275 280 285

Gly?Lys?Arg?Leu?Asn?Asp?Ser?Leu?Phe?Trp?Asn?Tyr?Asp?Gln?Thr?Ser

290 295 300

Phe?Thr?Thr?Asn?Thr?Lys?Asp?Tyr?Ser?Tyr?Leu?Lys?Leu?Thr?Asn?Asp

305 310 315 320

Lys?Asn?Asp?Ile?Val?Glu?Leu?Lys?Asn?Lys?Val?Pro?Thr?Glu?Ala?Glu

325 330 335

Asp?His?Asp?Gly?Asn?Arg?Leu?Met?Tyr?Gln?Phe?Gly?Ala?Thr?Phe?Thr

340 345 350

Gln?Lys?Ala?Leu?Met?Lys?Ala?Asp?Glu?Ile?Leu?Thr?Gln?Gln?Ala?Arg

355 360 365

Gln?Asn?Ser?Gln?Lys?Val?Ile?Phe?His?Ile?Thr?Asp?Gly?Val?Pro?Thr

370 375 380

Met?Ser?Tyr?Pro?Ile?Asn?Phe?Asn?His?Ala?Thr?Phe?Ala?Pro?Ser?Tyr

385 390 395 400

Gln?Asn?Gln?Leu?Asn?Ala?Phe?Phe?Ser?Lys?Ser?Pro?Asn?Lys?Asp?Gly

405 410 415

Ile?Leu?Leu?Ser?Asp?Phe?Ile?Thr?Gln?Ala?Thr?Ser?Gly?Glu?His?Thr

420 425 430

Ile?Val?Arg?Gly?Asp?Gly?Gln?Ser?Tyr?Gln?Met?Phe?Thr?Asp?Lys?Thr

435 440 445

Val?Tyr?Glu?Lys?Gly?Ala?Pro?Ala?Ala?Phe?Pro?Val?Lys?Pro?Glu?Lys

450 455 460

Tyr?Ser?Glu?Met?Lys?Ala?Ala?Gly?Tyr?Ala?Val?Ile?Gly?Asp?Pro?Ile

465 470 475 480

Asn?Gly?Gly?Tyr?Ile?Trp?Leu?Asn?Trp?Arg?Glu?Ser?Ile?Leu?Ala?Tyr

485 490 495

Pro?Phe?Asn?Ser?Asn?Thr?Ala?Lys?Ile?Thr?Asn?His?Gly?Asp?Pro?Thr

500 505 510

Arg?Trp?Tyr?Tyr?Asn?Gly?Asn?Ile?Ala?Pro?Asp?Gly?Tyr?Asp?Val?Phe

515 520 525

Thr?Val?Gly?Ile?Gly?Ile?Asn?Gly?Asp?Pro?Gly?Thr?Asp?Glu?Ala?Thr

530 535 540

Ala?Thr?Ser?Phe?Met?Gln?Ser?Ile?Ser?Ser?Lys?Pro?Glu?Asn?Tyr?Thr

545 550 555 560

Asn?Val?Thr?Asp?Thr?Thr?Lys?Ile?Leu?Glu?Gln?Leu?Asn?Arg?Tyr?Phe

565 570 575

His?Thr?Ile?Val?Thr?Glu?Lys?Lys?Ser?Ile?Glu?Asn?Gly?Thr?Ile?Thr

580 585 590

Asp?Pro?Met?Gly?Glu?Leu?Ile?Asp?Leu?Gln?Leu?Gly?Thr?Asp?Gly?Arg

595 600 605

Phe?Asp?Pro?Ala?Asp?Tyr?Thr?Leu?Thr?Ala?Asn?Asp?Gly?Ser?Arg?Leu

610 615 620

Glu?Asn?Gly?Gln?Ala?Val?Gly?Gly?Pro?Gln?Asn?Asp?Gly?Gly?Leu?Leu

625 630 635 640

Lys?Asn?Ala?Lys?Val?Leu?Tyr?Asp?Thr?Thr?Glu?Lys?Arg?Ile?Arg?Val

645 650 655

Thr?Gly?Leu?Tyr?Leu?Gly?Thr?Asp?Glu?Lys?Val?Thr?Leu?Thr?Tyr?Asn

660 665 670

Val?Arg?Leu?Asn?Asp?Glu?Phe?Val?Ser?Asn?Lys?Phe?Tyr?Asp?Thr?Asn

675 680 685

Gly?Arg?Thr?Thr?Leu?His?Pro?Lys?Glu?Val?Glu?Gln?Asn?Thr?Val?Arg

690 695 700

Asp?Phe?Pro?Ile?Pro?Lys?Ile?Arg?Asp?Val?Arg?Lys?Tyr?Pro?Glu?Ile

705 710 715 720

Thr?Ile?Ser?Lys?Glu?Lys?Lys?Leu?Gly?Asp?Ile?Glu?Phe?Ile?Lys?Val

725 730 735

Asn?Lys?Asn?Asp?Lys?Lys?Pro?Leu?Arg?Gly?Ala?Val?Phe?Ser?Leu?Gln

740 745 750

Lys?Gln?His?Pro?Asp?Tyr?Pro?Asp?Ile?Tyr?Gly?Ala?Ile?Asp?Gln?Asn

755 760 765

Gly?Thr?Tyr?Gln?Asn?Val?Arg?Thr?Gly?Glu?Asp?Gly?Lys?Leu?Thr?Phe

770 775 780

Lys?Asn?Leu?Ser?Asp?Gly?Lys?Tyr?Arg?Leu?Phe?Glu?Asn?Ser?Glu?Pro

785 790 795 800

Ala?Gly?Tyr?Lys?Pro?Val?Gln?Asn?Lys?Pro?Ile?Val?Ala?Phe?Gln?Ile

805 810 815

Val?Asn?Gly?Glu?Val?Arg?Asp?Val?Thr?Ser?Ile?Val?Pro?Gln?Asp?Ile

820 825 830

Pro?Ala?Gly?Tyr?Glu?Phe?Thr?Asn?Asp?Lys?His?Tyr?Ile?Thr?Asn?Glu

835 840 845

Pro?Ile?Pro?Pro?Lys?Arg?Glu?Tyr?Pro?Arg?Thr?Gly?Gly?Ile?Gly?Met

850 855 860

Leu?Pro?Phe?Tyr?Leu?Ile?Gly?Cys?Met?Met?Met?Gly?Gly?Val?Leu?Leu

865 870 875 880

Tyr?Thr?Arg?Lys?His?Pro

885

<210>127

<211>665

<212>PRT

＜213〉streptococcus pneumoniae

<400>127

Met?Lys?Set?Ile?Asn?Lys?Phe?Leu?Thr?Met?Leu?Ala?Ala?Leu?Leu?Leu

1 5 10 15

Thr?Ala?Ser?Ser?Leu?Phe?Ser?Ala?Ala?Thr?Val?Phe?Ala?Ala?Gly?Thr

20 25 30

Thr?Thr?Thr?Ser?Val?Thr?Val?His?Lys?Leu?Leu?Ala?Thr?Asp?Gly?Asp

35 40 45

Met?Asp?Lys?Ile?Ala?Asn?Glu?Leu?Glu?Thr?Gly?Asn?Tyr?Ala?Gly?Asn

50 55 60

Lys?Val?Gly?Val?Leu?Pro?Ala?Asn?Ala?Lys?Glu?Ile?Ala?Gly?Val?Met

65 70 75 80

Phe?Val?Trp?Thr?Asn?Thr?Asn?Asn?Glu?Ile?Ile?Asp?Glu?Asn?Gly?Gln

85 90 95

Thr?Leu?Gly?Val?Asn?Ile?Asp?Pro?Gln?Thr?Phe?Lys?Leu?Ser?Gly?Ala

100 105 110

Met?Pro?Ala?Thr?Ala?Met?Lys?Lys?Leu?Thr?Glu?Ala?Glu?Gly?Ala?Lys

115 120 125

Phe?Asn?Thr?Ala?Asn?Leu?Pro?Ala?Ala?Lys?Tyr?Lys?Ile?Tyr?Glu?Ile

130 135 140

His?Ser?Leu?Ser?Thr?Tyr?Val?Gly?Glu?Asp?Gly?Ala?Thr?Leu?Thr?Gly

145 150 155 160

Ser?Lys?Ala?Val?Pro?Ile?Glu?Ile?Glu?Leu?Pro?Leu?Asn?Asp?Val?Val

165 170 175

Asp?Ala?His?Val?Tyr?Pro?Lys?Asn?Thr?Glu?Ala?Lys?Pro?Lys?Ile?Asp

180 185 190

Lys?Asp?Phe?Lys?Gly?Lys?Ala?Asn?Pro?Asp?Thr?Pro?Arg?Val?Asp?Lys

195 200 205

Asp?Thr?Pro?Val?Asn?His?Gln?Val?Gly?Asp?Val?Val?Glu?Tyr?Glu?Ile

210 215 220

Val?Thr?Lys?Ile?Pro?Ala?Leu?Ala?Asn?Tyr?Ala?Thr?Ala?Asn?Trp?Ser

225 230 235 240

Asp?Arg?Met?Thr?Glu?Gly?Leu?Ala?Phe?Asn?Lys?Gly?Thr?Val?Lys?Val

245 250 255

Thr?Val?Asp?Asp?Val?Ala?Leu?Glu?Ala?Gly?Asp?Tyr?Ala?Leu?Thr?Glu

260 265 270

Val?Ala?Thr?Gly?Phe?Asp?Leu?Lys?Leu?Thr?Asp?Ala?Gly?Leu?Ala?Lys

275 280 285

Val?Asn?Asp?Gln?Asn?Ala?Glu?Lys?Thr?Val?Lys?Ile?Thr?Tyr?Ser?Ala

290 295 300

Thr?Leu?Asn?Asp?Lys?Ala?Ile?Val?Glu?Val?Pro?Glu?Ser?Asn?Asp?Val

305 310 315 320

Thr?Phe?Asn?Tyr?Gly?Asn?Asn?Pro?Asp?His?Gly?Asn?Thr?Pro?Lys?Pro

325 330 335

Asn?Lys?Pro?Asn?Glu?Asn?Gly?Asp?Leu?Thr?Leu?Thr?Lys?Thr?Trp?Val

340 345 350

Asp?Ala?Thr?Gly?Ala?Pro?Ile?Pro?Ala?Gly?Ala?Glu?Ala?Thr?Phe?Asp

355 360 365

Leu?Val?Asn?Ala?Gln?Thr?Gly?Lys?Val?Val?Gln?Thr?Val?Thr?Leu?Thr

370 375 380

Thr?Asp?Lys?Asn?Thr?Val?Thr?Val?Asn?Gly?Leu?Asp?Lys?Asn?Thr?Glu

385 390 395 400

Tyr?Lys?Phe?Val?Glu?Arg?Ser?Ile?Lys?Gly?Tyr?Ser?Ala?Asp?Tyr?Gln

405 410 415

Glu?Ile?Thr?Thr?Ala?Gly?Glu?Ile?Ala?Val?Lys?Asn?Trp?Lys?Asp?Glu

420 425 430

Asn?Pro?Lys?Pro?Leu?Asp?Pro?Thr?Glu?Pro?Lys?Val?Val?Thr?Tyr?Gly

435 440 445

Lys?Lys?Phe?Val?Lys?Val?Asn?Asp?Lys?Asp?Asn?Arg?Leu?Ala?Gly?Ala

450 455 460

Glu?Phe?Val?Ile?Ala?Asn?Ala?Asp?Asn?Ala?Gly?Gln?Tyr?Leu?Ala?Arg

465 470 475 480

Lys?Ala?Asp?Lys?Val?Ser?Gln?Glu?Glu?Lys?Gln?Leu?Val?Val?Thr?Thr

485 490 495

Lys?Asp?Ala?Leu?Asp?Arg?Ala?Val?Ala?Ala?Tyr?Asn?Ala?Leu?Thr?Ala

500 505 510

Gln?Gln?Gln?Thr?Gln?Gln?Glu?Lys?Glu?Lys?Val?Asp?Lys?Ala?Gln?Ala

515 520 525

Ala?Tyr?Asn?Ala?Ala?Val?Ile?Ala?Ala?Asn?Asn?Ala?Phe?Glu?Trp?Val

530 535 540

Ala?Asp?Lys?Asp?Asn?Glu?Asn?Val?Val?Lys?Leu?Val?Ser?Asp?Ala?Gln

545 550 555 560

Gly?Arg?Phe?Glu?Ile?Thr?Gly?Leu?Leu?Ala?Gly?Thr?Tyr?Tyr?Leu?Glu

565 570 575

Glu?Thr?Lys?Gln?Pro?Ala?Gly?Tyr?Ala?Leu?Leu?Thr?Ser?Arg?Gln?Lys

580 585 590

Phe?Glu?Val?Thr?Ala?Thr?Ser?Tyr?Ser?Ala?Thr?Gly?Gln?Gly?Ile?Glu

595 600 605

Tyr?Thr?Ala?Gly?Ser?Gly?Lys?Asp?Asp?Ala?Thr?Lys?Val?Val?Asn?Lys

610 615 620

Lys?Ile?Thr?Ile?Pro?Gln?Thr?Gly?Gly?Ile?Gly?Thr?Ile?Ile?Phe?Ala

625 630 635 640

Val?Ala?Gly?Ala?Ala?Ile?Met?Gly?Ile?Ala?Val?Tyr?Ala?Tyr?Val?Lys

645 650 655

Asn?Asn?Lys?Asp?Glu?Asp?Gln?Leu?Ala

660 665

<210>128

<211>390

<212>PRT

＜213〉streptococcus pneumoniae

<400>128

Met?Thr?Met?Gln?Lys?Met?Gln?Lys?Met?Ile?Ser?Arg?Ile?Phe?Phe?Val

1 5 10 15

Met?Ala?Leu?Cys?Phe?Ser?Leu?Val?Trp?Gly?Ala?His?Ala?Val?Gln?Ala

20 25 30

Gln?Glu?Asp?His?Thr?Leu?Val?Leu?Gln?Leu?Glu?Asn?Tyr?Gln?Glu?Val

35 40 45

Val?Ser?Gln?Leu?Pro?Ser?Arg?Asp?Gly?His?Arg?Leu?Gln?Val?Trp?Lys

50 55 60

Leu?Asp?Asp?Ser?Tyr?Ser?Tyr?Asp?Asp?Arg?Val?Gln?Ile?Val?Arg?Asp

65 70 75 80

Leu?His?Ser?Trp?Asp?Glu?Asn?Lys?Leu?Ser?Ser?Phe?Lys?Lys?Thr?Ser

85 90 95

Phe?Glu?Met?Thr?Phe?Leu?Glu?Asn?Gln?Ile?Glu?Val?Ser?His?Ile?Pro

100 105 110

Asn?Gly?Leu?Tyr?Tyr?Val?Arg?Ser?Ile?Ile?Gln?Thr?Asp?Ala?Val?Ser

115 120 125

Tyr?Pro?Ala?Glu?Phe?Leu?Phe?Glu?Met?Thr?Asp?Gln?Thr?Val?Glu?Pro

130 135 140

Leu?Val?Ile?Val?Ala?Lys?Lys?Thr?Asp?Thr?Met?Thr?Thr?Lys?Val?Lys

145 150 155 160

Leu?Ile?Lys?Val?Asp?Gln?Asp?His?Asn?Arg?Leu?Glu?Gly?Val?Gly?Phe

165 170 175

Lys?Leu?Val?Ser?Val?Ala?Arg?Asp?Val?Ser?Glu?Lys?Glu?Val?Pro?Leu

180 185 190

Ile?Gly?Glu?Tyr?Arg?Tyr?Ser?Ser?Ser?Gly?Gln?Val?Gly?Arg?Thr?Leu

195 200 205

Tyr?Thr?Asp?Lys?Asn?Gly?Glu?Ile?Phe?Val?Thr?Asn?Leu?Pro?Leu?Gly

210 215 220

Asn?Tyr?Arg?Phe?Lys?Glu?Val?Glu?Pro?Leu?Ala?Gly?Tyr?Ala?Val?Thr

225 230 235 240

Thr?Leu?Asp?Thr?Asp?Val?Gln?Leu?Val?Asp?His?Gln?Leu?Val?Thr?Ile

245 250 255

Thr?Val?Val?Asn?Gln?Lys?Leu?Pro?Arg?Gly?Asn?Val?Asp?Phe?Met?Lys

260 265 270

Val?Asp?Gly?Arg?Thr?Asn?Thr?Ser?Leu?Gln?Gly?Ala?Met?Phe?Lys?Val

275 280 285

Met?Lys?Glu?Glu?Ser?Gly?His?Tyr?Thr?Pro?Val?Leu?Gln?Asn?Gly?Lys

290 295 300

Glu?Val?Val?Val?Thr?Ser?Gly?Lys?Asp?Gly?Arg?Phe?Arg?Val?Glu?Gly

305 310 315 320

Leu?Glu?Tyr?Gly?Thr?Tyr?Tyr?Leu?Trp?Glu?Leu?Gln?Ala?Pro?Thr?Gly

325 330 335

Tyr?Val?Gln?Leu?Thr?Ser?Pro?Val?Ser?Phe?Thr?Ile?Gly?Lys?Asp?Thr

340 345 350

Arg?Lys?Glu?Leu?Val?Thr?Val?Val?Lys?Asn?Asn?Lys?Arg?Pro?Arg?Ile

355 360 365

Asp?Val?Pro?Asp?Thr?Gly?Glu?Glu?Thr?Leu?Val?Tyr?Leu?Asp?Ala?Cys

370 375 380

Cys?His?Phe?Val?Val?Trp

385 390

<210>129

<211>521

<212>PRT

＜213〉streptococcus pneumoniae

<400>129

Met?Ser?His?Ile?Tyr?Leu?Ser?Ile?Phe?Thr?Ser?Leu?Leu?Leu?Met?Leu

1 5 10 15

Gly?Leu?Val?Asn?Val?Ala?Gln?Ala?Asp?Glu?Tyr?Leu?Arg?Ile?Gly?Met

20 25 30

Glu?Ala?Ala?Tyr?Ala?Pro?Phe?Asn?Trp?Thr?Gln?Asp?Asp?Asp?Ser?Asn

35 40 45

Gly?Ala?Val?Lys?Ile?Asp?Gly?Thr?Asn?Gln?Tyr?Ala?Asn?Gly?Tyr?Asp

50 55 60

Val?Gln?Ile?Ala?Lys?Lys?Ile?Ala?Lys?Asp?Leu?Gly?Lys?Glu?Pro?Leu

65 70 75 80

Val?Val?Lys?Thr?Lys?Trp?Glu?Gly?Leu?Val?Pro?Ala?Leu?Thr?Ser?Gly

85 90 95

Lys?Ile?Asp?Met?Ile?Ile?Ala?Gly?Met?Ser?Pro?Thr?Ala?Glu?Arg?Lys

100 105 110

Gln?Glu?Ile?Ala?Phe?Ser?Ser?Ser?Tyr?Tyr?Thr?Ser?Glu?Pro?Val?Leu

115 120 125

Leu?Val?Lys?Lys?Asp?Ser?Ala?Tyr?Ala?Ser?Ala?Lys?Ser?Leu?Asp?Asp

130 135 140

Phe?Asn?Gly?Ala?Lys?Ile?Thr?Ser?Gln?Gln?Gly?Val?Tyr?Leu?Tyr?Asn

145 150 155 160

Leu?Ile?Ala?Gln?Ile?Pro?Gly?Ala?Lys?Lys?Glu?Thr?Ala?Met?Gly?Asp

165 170 175

Phe?Ala?Gln?Met?Arg?Gln?Ala?Leu?Glu?Ala?Gly?Val?Ile?Asp?Ala?Tyr

180 185 190

Val?Ser?Glu?Arg?Pro?Glu?Ala?Leu?Thr?Ala?Glu?Ala?Ala?Asn?Ser?Lys

195 200 205

Phe?Lys?Met?Ile?Gln?Val?Glu?Pro?Gly?Phe?Lys?Thr?Gly?Glu?Glu?Asp

210 215 220

Thr?Ala?Ile?AlaIle?Gly?Leu?Arg?Lys?Asn?Asp?Asn?Arg?Ile?Ser?Gln

225 230 235 240

Ile?Asn?Ala?Ser?Ile?Glu?Thr?Ile?Ser?Lys?Asp?Asp?Gln?Val?Ala?Leu

245 250 255

Met?Asp?Arg?Met?Ile?Lys?Glu?Gln?Pro?Ala?Glu?Ala?Thr?Thr?Thr?Glu

260 265 270

Glu?Thr?Ser?Ser?Ser?Phe?Phe?Ser?Gln?Val?Ala?Lys?Ile?Leu?Ser?Glu

275 280 285

Asn?Trp?Gln?Gln?Leu?Leu?Arg?Gly?Ala?Gly?Ile?Thr?Leu?Leu?Ile?Ser

290 295 300

Ile?Val?Gly?Thr?Ile?Ile?Gly?Leu?Ile?Ile?Gly?Leu?Ala?Ile?Gly?Val

305 310 315 320

Phe?Arg?Thr?Ala?Pro?Leu?Ser?Glu?Asn?Lys?Val?Ile?Tyr?Gly?Leu?Gln

325 330 335

Lys?Leu?Val?Gly?Trp?Val?Leu?Asn?Val?Tyr?Ile?Glu?Ile?Phe?Arg?Gly

340 345 350

Thr?Pro?Met?Ile?Val?Gln?Ser?Met?Val?Ile?Tyr?Tyr?Gly?Thr?Ala?Gln

355 360 365

Ala?Phe?Gly?Ile?Asn?Leu?Asp?Arg?Thr?Leu?Ala?Ala?Ile?Phe?Ile?Val

370 375 380

Ser?Ile?Asn?Thr?Gly?Ala?Tyr?Met?Thr?Glu?Ile?Val?Arg?Gly?Gly?Ile

385 390 395 400

Leu?Ala?Val?Asp?Lys?Gly?Gln?Phe?Glu?Ala?Ala?Thr?Ala?Leu?Gly?Met

405 410 415

Thr?His?Asn?Gln?Thr?Met?Arg?Lys?Ile?Val?Leu?Pro?Gln?Val?Val?Arg

420 425 430

Asn?Ile?Leu?Pro?Ala?Thr?Gly?Asn?Glu?Phe?Val?Ile?Asn?Ile?Lys?Asp

435 440 445

Thr?Ser?Val?Leu?Asn?Val?Ile?Ser?Val?Val?Glu?Leu?Tyr?Phe?Ser?Gly

450 455 460

Asn?Thr?Val?Ala?Thr?Gln?Thr?Tyr?Gln?Tyr?Phe?Gln?Thr?Phe?Thr?Ile

465 470 475 480

Ile?Ala?Val?Ile?Tyr?Phe?Val?Leu?Thr?Phe?Thr?Val?Thr?Arg?Ile?Leu

485 490 495

Arg?Phe?Ile?Glu?Arg?Arg?Met?Asp?Met?Asp?Thr?Tyr?Thr?Thr?Gly?Ala

500 505 510

Asn?Gln?Met?Gln?Thr?Glu?Asp?Leu?Lys

515 520

<210>130

<211>246

<212>PRT

＜213〉streptococcus pneumoniae

<400>130

Met?Thr?Gln?Ala?Ile?Leu?Glu?Ile?Lys?His?Leu?Lys?Lys?Ser?Tyr?Gly

1 5 10 15

Gln?Asn?Glu?Val?Leu?Lys?Asp?Ile?Ser?Leu?Thr?Val?His?Lys?Gly?Glu

20 25 30

Val?Ile?Ser?Ile?Ile?Gly?Ser?Ser?Gly?Ser?Gly?Lys?Ser?Thr?Phe?Leu

35 40 45

Arg?Ser?Ile?Asn?Leu?Leu?Glu?Thr?Pro?Thr?Asp?Gly?Gln?Ile?Leu?Tyr

50 55 60

His?Gly?Gln?Asn?Val?Leu?Glu?Lys?Gly?Tyr?Asp?Leu?Thr?Gln?Tyr?Arg

65 70 75 80

Glu?Lys?Leu?Gly?Met?Val?Phe?Gln?Ser?Phe?Asn?Leu?Phe?Glu?Asn?Leu

85 90 95

Asn?Val?Leu?Glu?Asn?Thr?Ile?Val?Ala?Gln?Thr?Thr?Val?Leu?Lys?Arg

100 105 110

Glu?Arg?Thr?Glu?Ala?Glu?Lys?Ile?Ala?Lys?Glu?Asn?Leu?Glu?Lys?Val

115 120 125

Gly?Met?Gly?Glu?Arg?Tyr?Trp?Gln?Ala?Lys?Pro?Lys?Gln?Leu?Ser?Gly

130 135 140

Gly?Gln?Lys?Gln?Arg?Val?Ala?Ile?Ala?Arg?Ala?Leu?Ser?Met?Asn?Pro

145 150 155 160

Asp?Ala?Ile?Leu?Phe?Asp?Glu?Pro?Thr?Ser?Ala?Leu?Asp?Pro?Glu?Met

165 170 175

Val?Gly?Glu?Val?Leu?Lys?Ile?Met?Gln?Asp?Leu?Ala?Gln?Glu?Gly?Leu

180 185 190

Thr?Met?Ile?Val?Val?Thr?His?Glu?Met?Glu?Phe?Ala?Arg?Asp?Val?Ser

195 200 205

His?Arg?Val?Ile?Phe?Met?Asp?Lys?Gly?Val?Ile?Ala?Glu?Glu?Gly?Lys

210 215 220

Pro?Glu?Asp?Leu?Phe?Thr?Asn?Pro?Lys?Glu?Asp?Arg?Thr?Lys?Glu?Phe

225 230 235 240

Leu?Gln?Arg?Tyr?Leu?Lys

245

<210>131

<211>229

<212>PRT

＜213〉streptococcus pneumoniae

<400>131

Met?Lys?Lys?Tyr?Gln?Leu?Leu?Phe?Lys?Ile?Ser?Ala?Val?Phe?Ser?Tyr

1 5 10 15

Leu?Phe?Phe?Val?Phe?Ser?Leu?Ser?Gln?Leu?Thr?Leu?Ile?Val?Gln?Asn

20 25 30

Tyr?Trp?Gln?Phe?Ser?Ser?Gln?Ile?Gly?Asn?Leu?Phe?Trp?Ile?Gln?Asn

35 40 45

Ile?Leu?Ser?Leu?Leu?Phe?Ile?Gly?Val?Met?Ile?Val?Val?Leu?Val?Lys

50 55 60

Thr?Gly?His?Gly?Tyr?Leu?Phe?Arg?Ile?Pro?Arg?Lys?Lys?Trp?Leu?Trp

65 70 75 80

Tyr?Ser?Ile?Leu?Thr?Val?Leu?Val?Leu?Val?Phe?Gln?Ile?Ser?Phe?Asn

85 90 95

Val?Gln?Thr?Ala?Lys?His?Val?Gln?Ser?Thr?Ala?Glu?Gly?Trp?Ala?Val

100 105 110

Leu?Ile?Gly?Tyr?Ser?Gly?Thr?Asn?Phe?Ala?Glu?Leu?Gly?Ile?Tyr?Ile

115 120 125

Ala?Leu?Phe?Phe?Leu?Val?Pro?Leu?Met?Glu?Glu?Leu?Ile?Tyr?Arg?Gly

130 135 140

Leu?Leu?Gln?His?Ala?Phe?Phe?Lys?His?Ser?Arg?Phe?Gly?Leu?Asp?Leu

145 150 155 160

Leu?Leu?Pro?Ser?Ile?Leu?Phe?Ala?Leu?Pro?His?Phe?Ser?Ser?Leu?Pro

165 170 175

Ser?Leu?Leu?Asp?Ile?Phe?Val?Phe?Ala?Thr?Val?Gly?Ile?Ile?Phe?Ala

180 185 190

Gly?Leu?Thr?Arg?Tyr?Thr?Lys?Ser?Ile?Tyr?Pro?Ser?Tyr?Ala?Val?His

195 200 205

Val?Ile?Asn?Asn?Ile?Val?Ala?Thr?Phe?Pro?Phe?Leu?Leu?Thr?Phe?Leu

210 215 220

His?Arg?Val?Leu?Gly

225

<210>132

<211>350

<212>PRT

＜213〉streptococcus pneumoniae

<400>132

Met?Asn?Lys?Lys?Gln?Trp?Leu?Gly?Leu?Gly?Leu?Val?Ala?Val?Ala?Ala

1 5 10 15

Val?Gly?Leu?Ala?Ala?Cys?Gly?Asn?Arg?Ser?Ser?Arg?Asn?Ala?Ala?Ser

20 25 30

Ser?Ser?Asp?Val?Lys?Thr?Lys?Ala?Ala?Ile?Val?Thr?Asp?Thr?Gly?Gly

35 40 45

Val?Asp?Asp?Lys?Ser?Phe?Asn?Gln?Ser?Ala?Trp?Glu?Gly?Leu?Gln?Ala

50 55 60

Trp?Gly?Lys?Glu?His?Asn?Leu?Ser?Lys?Asp?Asn?Gly?Phe?Thr?Tyr?Phe

65 70 75 80

Gln?Ser?Thr?Ser?Glu?Ala?Asp?Tyr?Ala?Asn?Asn?Leu?Gln?Gln?Ala?Ala

85 90 95

Gly?Ser?Tyr?Asn?Leu?Ile?Phe?Gly?Val?Gly?Phe?Ala?Leu?Asn?Asn?Ala

100 105 110

Val?Lys?Asp?Ala?Ala?Lys?Glu?His?Thr?Asp?Leu?Asn?Tyr?Val?Leu?Ile

115 120 125

Asp?Asp?Val?Ile?Lys?Asp?Gln?Lys?Asn?Val?Ala?Ser?Val?Thr?Phe?Ala

130 135 140

Asp?Asn?Glu?Ser?Gly?Tyr?Leu?Ala?Gly?Val?Ala?Ala?Ala?Lys?Thr?Thr

145 150 155 160

Lys?Thr?Lys?Gln?Val?Gly?Phe?Val?Gly?Gly?Ile?Glu?Ser?Glu?Val?Ile

165 170 175

Ser?Arg?Phe?Glu?Ala?Gly?Phe?Lys?Ala?Gly?Val?Ala?Ser?Val?Asp?Pro

180 185 190

Ser?Ile?Lys?Val?Gln?Val?Asp?Tyr?Ala?Gly?Ser?Phe?Gly?Asp?Ala?Ala

195 200 205

Lys?Gly?Lys?Thr?Ile?Ala?Ala?Ala?Gln?Tyr?Ala?Ala?Gly?Ala?Asp?Ile

210 215 220

Val?Tyr?Gln?Val?Ala?Gly?Gly?Thr?Gly?Ala?Gly?Val?Phe?Ala?Glu?Ala

225 230 235 240

Lys?Ser?Leu?Asn?Glu?Ser?Arg?Pro?Glu?Asn?Glu?Lys?Val?Trp?Val?Ile

245 250 255

Gly?Val?Asp?Arg?Asp?Gln?Glu?Ala?Glu?Gly?Lys?Tyr?Thr?Ser?Lys?Asp

260 265 270

Gly?Lys?Glu?Ser?Asn?Phe?Val?Leu?Val?Ser?Thr?Leu?Lys?Gln?Val?Gly

275 280 285

Thr?Thr?Val?Lys?Asp?Ile?Ser?Asn?Lys?Ala?Glu?Arg?Gly?Glu?Phe?Pro

290 295 300

Gly?Gly?Gln?Val?Ile?Val?Tyr?Ser?Leu?Lys?Asp?Lys?Gly?Val?Asp?Leu

305 310 315 320

Ala?Val?Thr?Asn?Leu?Ser?Glu?Glu?Gly?Lys?Lys?Ala?Val?Glu?Asp?Ala

325 330 335

Lys?Ala?Lys?Ile?Leu?Asp?Gly?Ser?Val?Lys?Val?Pro?Glu?Lys

340 345 350

<210>133

<211>352

<212>PRT

＜213〉streptococcus pneumoniae

<400>133

Met?Ser?Lys?Lys?Leu?Gln?Gln?Ile?Ser?Val?Pro?Leu?Ile?Ser?Val?Phe

1 5 10 15

Leu?Gly?Ile?Leu?Leu?Gly?Ala?Ile?Val?Met?Trp?Ile?Phe?Gly?Tyr?Asp

20 25 30

Ala?Ile?Trp?Gly?Tyr?Glu?Glu?Leu?Phe?Tyr?Thr?Ala?Phe?Gly?Ser?Leu

35 40 45

Arg?Gly?Ile?Gly?Glu?Ile?Phe?Arg?Ala?Met?Gly?Pro?Leu?Val?Leu?Ile

50 55 60

Gly?Leu?Gly?Phe?Ala?Val?Ala?Ser?Arg?Ala?Gly?Phe?Phe?Asn?Val?Gly

65 70 75 80

Leu?Pro?Gly?Gln?Ala?Leu?Ala?Gly?Trp?Ile?Leu?Ser?Gly?Trp?Phe?Ala

85 90 95

Leu?Ser?His?Pro?Asp?Met?Pro?Arg?Pro?Leu?Met?Ile?Leu?Ala?Thr?Ile

100 105 110

Val?Ile?Ala?Leu?Ile?Ala?Gly?Gly?Ile?Val?Gly?Ala?Ile?Pro?Gly?Ile

115 120 125

Leu?Arg?Ala?Tyr?Leu?Gly?Thr?Ser?Glu?Val?Ile?Val?Thr?Ile?Met?Met

130 135 140

Asn?Tyr?Ile?Val?Leu?Tyr?Val?Gly?Asn?Ala?Phe?Ile?His?Ala?Phe?Pro

145 150 155 160

Lys?Asp?Phe?Met?Gln?Ser?Thr?Asp?Ser?Thr?Ile?Arg?Val?Gly?Ala?Asn

165 170 175

Ala?Thr?Tyr?Gln?Thr?Pro?Trp?Leu?Ala?Glu?Leu?Thr?Gly?Asn?Ser?Arg

180 185 190

Met?Asn?Ile?Gly?Ile?Phe?Phe?Ala?Ile?Ile?Ala?Val?Ala?Val?Ile?Trp

195 200 205

Phe?Met?Leu?Lys?Lys?Thr?Thr?Leu?Gly?Phe?Glu?Ile?Arg?Ala?Val?Gly

210 215 220

Leu?Asn?Pro?His?Ala?Ser?Glu?Tyr?Ala?Gly?Ile?Ser?Ala?Lys?Arg?Thr

225 230 235 240

Ile?Ile?Leu?Ser?Met?Ile?Ile?Ser?Gly?Ala?Leu?Ala?Gly?Leu?Gly?Gly

245 250 255

Ala?Val?Glu?Gly?Leu?Gly?Thr?Phe?Gln?Asn?Val?Tyr?Val?Gln?Gly?Ser

260 265 270

Ser?Leu?Ala?Ile?Gly?Phe?Asn?Gly?Met?Ala?Val?Ser?Leu?Leu?Ala?Ala

275 280 285

Asn?Ser?Pro?Ile?Gly?Ile?Leu?Phe?Ala?Ala?Phe?Leu?Phe?Gly?Val?Leu

290 295 300

Gln?Val?Gly?Ala?Pro?Gly?Met?Asn?Ala?Ala?Gln?Val?Pro?Ser?Glu?Leu

305 310 315 320

Val?Ser?Ile?Val?Thr?Ala?Ser?Ile?Ile?Phe?Phe?Val?Ser?Val?His?Tyr

325 330 335

Leu?Ile?Glu?Arg?Phe?Val?Lys?Pro?Lys?Lys?Gln?Val?Lys?Gly?Gly?Lys

340 345 350

<210>134

<211>276

<212>PRT

＜213〉streptococcus pneumoniae

<400>134

Met?Gly?Val?Lys?Lys?Lys?Leu?Lys?Leu?Thr?Ser?Leu?Leu?Gly?Leu?Ser

1 5 10 15

Leu?Leu?Ile?Met?Thr?Ala?Cys?Ala?Thr?Asn?Gly?Val?Thr?Ser?Asp?Ile

20 25 30

Thr?Ala?Glu?Ser?Ala?Asp?Phe?Trp?Ser?Lys?Leu?Val?Tyr?Phe?Phe?Ala

35 40 45

Glu?Ile?Ile?Arg?Phe?Leu?Ser?Phe?Asp?Ile?Ser?Ile?Gly?Val?Gly?Ile

50 55 60

Ile?Leu?Phe?Thr?Val?Leu?Ile?Arg?Thr?Val?Leu?Leu?Pro?Val?Phe?Gln

65 70 75 80

Val?Gln?Met?Val?Ala?Ser?Arg?Lys?Met?Gln?Glu?Ala?Gln?Pro?Arg?Ile

85 90 95

Lys?Ala?Leu?Arg?Glu?Gln?Tyr?Pro?Gly?Arg?Asp?Met?Glu?Ser?Arg?Thr

100 105 110

Lys?Leu?Glu?Gln?Glu?Met?Arg?Lys?Val?Phe?Lys?Glu?Met?Gly?Val?Arg

115 120 125

Gln?Ser?Asp?Ser?Leu?Trp?Pro?Ile?Leu?Ile?Gln?Met?Pro?Val?Ile?Leu

130 135 140

Ala?Leu?Phe?Gln?Ala?Leu?Ser?Arg?Val?Asp?Phe?Leu?Lys?Thr?Gly?His

145 150 155 160

Phe?Leu?Trp?Ile?Asn?Leu?Gly?Ser?Val?Asp?Thr?Thr?Leu?Val?Leu?Pro

165 170 175

Ile?Leu?Ala?Ala?Val?Phe?Thr?Phe?Leu?Ser?Thr?Trp?Leu?Ser?Asn?Lys

180 185 190

Ala?Leu?Ser?Glu?Arg?Asn?Gly?Ala?Thr?Thr?Ala?Met?Met?Tyr?Gly?Ile

195 200 205

Pro?Val?Leu?Ile?Phe?Ile?Phe?Ala?Val?Tyr?Ala?Pro?Gly?Gly?Val?Ala

210 215 220

Leu?Tyr?Trp?Thr?Val?Ser?Asn?Ala?Tyr?Gln?Val?Leu?Gln?Thr?Tyr?Phe

225 230 235 240

Leu?Asn?Asn?Pro?Phe?Lys?Ile?Ile?Ala?Glu?Arg?Glu?Ala?Val?Val?Gln

245 250 255

Ala?Gln?Lys?Asp?Leu?Glu?Asn?Arg?Lys?Arg?Lys?Ala?Lys?Lys?Lys?Ala

260 265 270

Gln?Lys?Thr?Lys

275

<210>135

<211>264

<212>PRT

＜213〉streptococcus pneumoniae

<400>135

Met?Val?Ile?Asp?Pro?Phe?Ala?Ile?Asn?Glu?Leu?Asp?Tyr?Tyr?Leu?Val

1 5 10 15

Ser?His?Phe?His?Ser?Asp?His?Ile?Asp?Pro?Tyr?Thr?Ala?Ala?Ala?Ile

20 25 30

Leu?Asn?Asn?Pro?Lys?Leu?Glu?His?Val?Lys?Phe?Ile?Gly?Pro?Tyr?His

35 40 45

Cys?Gly?Arg?Ile?Trp?Glu?Gly?Trp?Gly?Val?Pro?Lys?Glu?Arg?Ile?Ile

50 55 60

Val?Val?Lys?Pro?Gly?Asp?Thr?Ile?Glu?Leu?Lys?Asp?Met?Lys?Ile?His

65 70 75 80

Ala?Val?Glu?Ser?Phe?Asp?Arg?Thr?Cys?Leu?Val?Thr?Leu?Pro?Val?Asn

85 90 95

Gly?Ala?Asp?Glu?Thr?Gly?Gly?Glu?Leu?Ala?Gly?Leu?Ala?Val?Thr?Asp

100 105 110

Glu?Glu?Met?Ala?Gln?Lys?Ala?Val?Asn?Tyr?Ile?Phe?Glu?Thr?Pro?Gly

115 120 125

Gly?Thr?Ile?Tyr?His?Gly?Ala?Asp?Ser?His?Phe?Ser?Asn?Tyr?Phe?Ala

130 135 140

Lys?His?Gly?Lys?Asp?Phe?Lys?Ile?Asp?Val?Ala?Leu?Asn?Asn?Tyr?Gly

145 150 155 160

Glu?Asn?Pro?Val?Gly?Ile?Gln?Asp?Lys?Met?Thr?Ser?Ile?Asp?Leu?Leu

165 170 175

Arg?Met?Ala?Glu?Asn?Leu?Arg?Thr?Lys?Val?Ile?Ile?Pro?Val?His?Tyr

180 185 190

Asp?Ile?Trp?Ser?Asn?Phe?Met?Ala?Ser?Thr?Asn?Glu?Ile?Leu?Glu?Leu

195 200 205

Trp?Lys?Met?Arg?Lys?Asp?Arg?Leu?Gln?Tyr?Asp?Phe?His?Pro?Phe?Ile

210 215 220

Trp?Glu?Val?Gly?Gly?Lys?Tyr?Thr?Tyr?Pro?Gln?Asp?Gln?His?Leu?Val

225 230 235 240

Glu?Tyr?His?His?Pro?Arg?Gly?Phe?Asp?Asp?Cys?Phe?Glu?Gln?Asp?Ser

245 250 255

Asn?Ile?Gln?Phe?Lys?Ala?Leu?Leu

260

<210>136

<211>194

<212>PRT

＜213〉streptococcus pneumoniae

<400>136

Met?Phe?Leu?Ser?Gly?Trp?Leu?Ser?Ser?Phe?Ala?Asn?Thr?Tyr?Ile?His

1 5 10 15

Asp?Leu?Leu?Gly?Val?Leu?Phe?Pro?Asp?Ser?Pro?Phe?Leu?Asn?Ala?Phe

20 25 30

Glu?Ser?Ala?Ile?Ala?Ala?Pro?Leu?Val?Glu?Glu?Pro?Leu?Lys?Leu?Leu

35 40 45

Ser?Leu?Val?Phe?Val?Leu?Ala?Leu?Ile?Pro?Val?Arg?Lys?Leu?Lys?Ser

50 55 60

Leu?Phe?Leu?Leu?Gly?Ile?Ala?Ser?Gly?Leu?Gly?Phe?Gln?Met?Ile?Lys

65 70 75 80

Asp?Ile?Gly?Tyr?Ile?Arg?Thr?Asp?Leu?Pro?Glu?Gly?Phe?Asp?Phe?Thr

85 90 95

Ile?Ser?Arg?Ile?Leu?Glu?Arg?Ile?Ile?Ser?Gly?Ile?Ala?Ser?His?Trp

100 105 110

Thr?Phe?Ser?Gly?Leu?Ala?Val?Val?Gly?Val?Tyr?Leu?Leu?Tyr?Arg?Ala

115 120 125

Tyr?Lys?Gly?Gln?Lys?Val?Gly?Lys?Lys?Gln?Gly?Leu?Ile?Phe?Leu?Gly

130 135 140

Leu?Ala?Leu?Gly?Thr?His?Phe?Leu?Phe?Asn?Ser?Pro?Phe?Val?Glu?Leu

145 150 155 160

Glu?Thr?Glu?Leu?Pro?Leu?Ala?Ile?Pro?Val?Val?Thr?Ala?Ile?Ala?Leu

165 170 175

Tyr?Gly?Phe?Tyr?His?Ala?Tyr?Cys?Phe?Val?Glu?Lys?His?Asn?Glu?Leu

180 185 190

Met?Thr

<210>137

<211>129

<212>PRT

＜213〉streptococcus pneumoniae

<400>137

Met?Lys?Val?Glu?Pro?Arg?Cys?Asp?Val?Leu?Ser?Arg?Met?Ser?His?Phe

1 5 10 15

Phe?Ile?Arg?Ile?Leu?Ile?Met?Glu?Leu?Gln?Glu?Leu?Val?Glu?Arg?Ser

20 25 30

Trp?Ala?Ile?Arg?Gln?Ala?Tyr?His?Glu?Leu?Glu?Val?Lys?His?His?Asp

35 40 45

Ser?Lys?Trp?Thr?Val?Glu?Glu?Asp?Leu?Leu?Ala?Leu?Ser?Asn?Asp?Ile

50 55 60

Gly?Asn?Phe?Gln?Arg?Leu?Val?Met?Thr?Lys?Gln?Gly?Arg?Tyr?Tyr?Asp

65 70 75 80

Glu?Thr?Pro?Tyr?Thr?Leu?Glu?Gln?Lys?Leu?Ser?Glu?Asn?lle?Trp?Trp

85 90 95

Leu?Leu?Glu?Leu?Ser?Gln?Arg?Leu?Asp?Ile?Asp?Ile?Leu?Thr?Glu?Met

100 105 110

Glu?Asn?Phe?Leu?Ser?Asp?Lys?Glu?Lys?Gln?Leu?Asn?Val?Arg?Thr?Trp

115 120 125

Lys

<210>138

<211>324

<212>PRT

＜213〉streptococcus pneumoniae

<400>138

Met?Leu?Asp?Trp?Lys?Gln?Phe?Phe?Leu?Ala?Tyr?Leu?Arg?Ser?Arg?Ser

1 5 10 15

Arg?Leu?Phe?Ile?Tyr?Leu?Leu?Ser?Leu?Ala?Phe?Leu?Val?Leu?Leu?Phe

20 25 30

Gln?Phe?Leu?Phe?Ala?Ser?Leu?Gly?Ile?Tyr?Phe?Leu?Tyr?Phe?Phe?Phe

35 40 45

Leu?Cys?Cys?Phe?Val?Thr?Ile?Leu?Phe?Phe?Thr?Trp?Asp?Ile?Leu?Val

50 55 60

Glu?Thr?Gln?Val?Tyr?Arg?Gln?Glu?Leu?Leu?Tyr?Gly?Glu?Arg?Glu?Ala

65 70 75 80

Lys?Ser?Pro?Leu?Glu?Ile?Ala?Leu?Ala?Glu?Lys?Leu?Glu?Ala?Arg?Glu

85 90 95

Met?Glu?Leu?Tyr?Gln?Gln?Arg?Ser?Lys?Ala?Glu?Arg?Lys?Leu?Thr?Asp

100 105 110

Leu?Leu?Asp?Tyr?Tyr?Thr?Leu?Trp?Val?His?Gln?Ile?Lys?Thr?Pro?Ile

115 120 125

Ala?Ala?Ser?Gln?Leu?Leu?Val?Ala?Glu?Val?Val?Asp?Arg?Gln?Leu?Lys

130 135 140

Gln?Gln?Leu?Glu?Gln?Glu?Ile?Phe?Lys?Ile?Asp?Ser?Tyr?Thr?Asn?Leu

145 150 155 160

Val?Leu?Gln?Tyr?Leu?Arg?Leu?Glu?Ser?Phe?His?Asp?Asp?Leu?Val?Leu

165 170 175

Lys?Gln?Val?Gln?Ile?Glu?Asp?Leu?Val?Lys?Glu?Ile?Ile?Arg?Lys?Tyr

180 185 190

Ala?Leu?Phe?Phe?Ile?Gln?Lys?Gly?Leu?Asn?Val?Asn?Leu?His?Asp?Leu

195 200 205

Asp?Lys?Glu?Ile?Val?Thr?Asp?Lys?Lys?Trp?Leu?Leu?Val?Val?Ile?Glu

210 215 220

Gln?Ile?Ile?Ser?Asn?Ser?Leu?Lys?Tyr?Thr?Lys?Glu?Gly?Gly?Leu?Glu

225 230 235 240

Ile?Tyr?Met?Asp?Asp?Gln?Glu?Leu?Cys?Ile?Lys?Asp?Thr?Gly?Ile?Gly

245 250 255

Ile?Lys?Asn?Ser?Asp?Val?Leu?Arg?Val?Phe?Glu?Arg?Gly?Phe?Ser?Gly

260 265 270

Tyr?Asn?Gly?Arg?Leu?Thr?Gln?Gln?Ser?Ser?Gly?Leu?Gly?Leu?Tyr?Leu

275 280 285

Ser?Lys?Lys?Ile?Ser?Glu?Glu?Leu?Gly?His?Gln?Ile?Arg?Ile?Glu?Ser

290 295 300

Glu?Val?Gly?Lys?Gly?Thr?Thr?Val?Arg?Ile?Gln?Phe?Ala?Gln?Val?Asn

305 310 315 320

Leu?Val?Leu?Glu

<210>139

<211>195

<212>PRT

＜213〉streptococcus pneumoniae

<400>139

Met?Glu?Leu?Asn?Thr?His?Asn?Ala?Glu?Ile?Leu?Leu?Ser?Ala?Ala?Asn

1 5 10 15

Lys?Ser?His?Tyr?Pro?Gln?Asp?Glu?Leu?Pro?Glu?Ile?Ala?Leu?Ala?Gly

20 25 30

Arg?Ser?Asn?Val?Gly?Lys?Ser?Ser?Phe?Ile?Asn?Thr?Met?Leu?Asn?Arg

35 40 45

Lys?Asn?Leu?Ala?Arg?Thr?Ser?Gly?Lys?Pro?Gly?Lys?Thr?Gln?Leu?Leu

50 55 60

Asn?Phe?Phe?Asn?Ile?Asp?Asp?Lys?Met?Arg?Phe?Val?Asp?Val?Pro?Gly

65 70 75 80

Tyr?Gly?Tyr?Ala?Arg?Val?Ser?Lys?Lys?Glu?Arg?Glu?Lys?Trp?Gly?Cys

85 90 95

Met?Ile?Glu?Glu?Tyr?Leu?Thr?Thr?Arg?Glu?Asn?Leu?Arg?Ala?Val?Val

100 105 110

Ser?Leu?Val?Asp?Leu?Arg?His?Asp?Pro?Ser?Ala?Asp?Asp?Val?Gln?Met

115 120 125

Tyr?Glu?Phe?Leu?Lys?Tyr?Tyr?Glu?Ile?Pro?Val?Ile?Ile?Val?Ala?Thr

130 135 140

Lys?Ala?Asp?Lys?Ile?Pro?Arg?Gly?Lys?Trp?Asn?Lys?His?Glu?Ser?Ala

145 150 155 160

Ile?Lys?Lys?Lys?Leu?Asn?Phe?Asp?Pro?Ser?Asp?Asp?Phe?Ile?Leu?Phe

165 170 175

Ser?Ser?Val?Ser?Lys?Ala?Gly?Met?Asp?Glu?Ala?Trp?Asp?Ala?Ile?Leu

180 185 190

Glu?Lys?Leu

195

<210>140

<211>296

<212>PRT

＜213〉streptococcus pneumoniae

<400>140

Met?Thr?Lys?Lys?Gln?Leu?His?Leu?Val?Ile?Val?Thr?Gly?Met?Ser?Gly

1 5 10 15

Ala?Gly?Lys?Thr?Val?Ala?Ile?Gln?Ser?Phe?Glu?Asp?Leu?Gly?Tyr?Phe

20 25 30

Thr?Ile?Asp?Asn?Met?Pro?Pro?Ala?Leu?Leu?Pro?Lys?Phe?Leu?Gln?Leu

35 40 45

Val?Glu?Ile?Lys?Glu?Asp?Asn?Pro?Lys?Leu?Ala?Leu?Val?Val?Asp?Met

50 55 60

Arg?Ser?Arg?Ser?Phe?Phe?Ser?Glu?Ile?Gln?Ala?Val?Leu?Asp?Glu?Leu

65 70 75 80

Glu?Asn?Gln?Asp?Gly?Leu?Asp?Phe?Lys?Ile?Leu?Phe?Leu?Asp?Ala?Ala

85 90 95

Asp?Lys?Glu?Leu?Val?Ala?Arg?Tyr?Lys?Glu?Thr?Arg?Arg?Ser?His?Pro

100 105 110

Leu?Ala?Ala?Asp?Gly?Arg?Ile?Leu?Asp?Gly?Ile?Lys?Leu?Glu?Arg?Glu

115 120 125

Leu?Leu?Ala?Pro?Leu?Lys?Asn?Met?Ser?Gln?Asn?Val?Val?Asp?Thr?Thr

130 135 140

Glu?Leu?Thr?Pro?Arg?Glu?Leu?Arg?Lys?Thr?Leu?Ala?Glu?Gln?Phe?Ser

145 150 155 160

Asp?Gln?Glu?Gln?Ala?Gln?Ser?Phe?Arg?Ile?Glu?Val?Met?Ser?Phe?Gly

165 170 175

Phe?Lys?Tyr?Gly?Ile?Pro?Ile?Asp?Ala?Asp?Leu?Val?Phe?Asp?Val?Arg

180 185 190

Phe?Leu?Pro?Asn?Pro?Tyr?Tyr?Leu?Pro?Glu?Leu?Arg?Asn?Gln?Thr?Gly

195 200 205

Val?Asp?Glu?Pro?Val?Tyr?Asp?Tyr?Val?Met?Asn?His?Pro?Glu?Ser?Glu

210 215 220

Asp?Phe?Tyr?Gln?His?Leu?Leu?Ala?Leu?Ile?Glu?Pro?Ile?Leu?Pro?Ser

225 230 235 240

Tyr?Gln?Lys?Glu?Gly?Lys?Ser?Val?Leu?Thr?Ile?Ala?Met?Gly?Cys?Thr

245 250 255

Gly?Gly?Gln?His?Arg?Ser?Val?Ala?Phe?Ala?Lys?Arg?Leu?Ala?Gln?Asp

260 265 270

Leu?Ser?Lys?Asn?Trp?Ser?Val?Asn?Glu?Gly?His?Arg?Asp?Lys?Asp?Arg

275 280 285

Arg?Lys?Glu?Thr?Val?Asn?Arg?Ser

290 295

<210>141

<211>325

<212>PRT

＜213〉streptococcus pneumoniae

<400>141

Met?Arg?Lys?Pro?Lys?Ile?Thr?Val?Ile?Gly?Gly?Gly?Thr?Gly?Ser?Pro

1 5 10 15

Val?Ile?Leu?Lys?Ser?Leu?Arg?Glu?Lys?Asp?Val?Glu?Ile?Ala?Ala?Ile

20 25 30

Val?Thr?Val?Ala?Asp?Asp?Gly?Gly?Ser?Ser?Gly?Glu?Leu?Arg?Lys?Asn

35 40 45

Met?Gln?Gln?Leu?Thr?Pro?Pro?Gly?Asp?Leu?Arg?Asn?Val?Leu?Val?Ala

50 55 60

Met?Ser?Asp?Met?Pro?Lys?Phe?Tyr?Glu?Lys?Val?Phe?Gln?Tyr?Arg?Phe

65 70 75 80

Ser?Glu?Asp?Ala?Gly?Ala?Phe?Ala?Gly?His?Pro?Leu?Gly?Asn?Leu?Ile

85 90 95

Ile?Ala?Gly?Leu?Ser?Glu?Met?Gln?Gly?Ser?Thr?Tyr?Asn?Ala?Met?Gln

100 105 110

Leu?Leu?Ser?Lys?Phe?Phe?His?Thr?Thr?Gly?Lys?Ile?Tyr?Pro?Ser?Ser

115 120 125

Asp?His?Pro?Leu?Thr?Leu?His?Ala?Val?Phe?Gln?Asp?Gly?Thr?Glu?Val

130 135 140

Ala?Gly?Glu?Ser?His?Ile?Val?Asp?His?Arg?Gly?Ile?Ile?Asp?Asn?Val

145 150 155 160

Tyr?Val?Thr?Asn?Ala?Leu?Asn?Asp?Asp?Thr?Pro?Leu?Ala?Ser?Arg?Arg

165 170 175

Val?Val?Gln?Thr?Ile?Leu?Glu?Ser?Asp?Met?Ile?Val?Leu?Gly?Pro?Gly

180 185 190

Ser?Leu?Phe?Thr?Ser?Ile?Leu?Pro?Asn?Ile?Val?Ile?Lys?Glu?Ile?Gly

195 200 205

Arg?Ala?Leu?Leu?Glu?Thr?Lys?Ala?Glu?Ile?Ala?Tyr?Val?Cys?Asn?Ile

210 215 220

Met?Thr?Gln?Arg?Gly?Glu?Thr?Glu?His?Phe?Thr?Asp?Ser?Asp?His?Val

225 230 235 240

Glu?Val?Leu?His?Arg?His?Leu?Gly?Arg?Pro?Phe?Ile?Asp?Thr?Val?Leu

245 250 255

Val?Asn?Ile?Glu?Lys?Val?Pro?Gln?Glu?Tyr?Met?Asn?Ser?Asn?Arg?Phe

260 265 270

Asp?Glu?Tyr?Leu?Val?Gln?Val?Glu?His?Asp?Phe?Val?Gly?Leu?Cys?Lys

275 280 285

Gln?Val?Ser?Arg?Val?Ile?Ser?Ser?Asn?Phe?Leu?Arg?Leu?Glu?Asn?Gly

290 295 300

Gly?Ala?Phe?His?Asp?Gly?Asp?Leu?Ile?Val?Asp?Glu?Leu?Met?Arg?Ile

305 310 315 320

Ile?Gln?Val?Lys?Lys

325

<210>142

<211>392

<212>PRT

＜213〉streptococcus pneumoniae

<400>142

Met?Lys?Asn?Leu?Ile?Lys?Leu?Leu?Ile?Ile?Arg?Leu?Ile?Val?Asn?Leu

1 5 10 15

Ala?Asp?Ser?Val?Phe?Tyr?Ile?Val?Ala?Leu?Trp?His?Val?Ser?Asn?Asn

20 25 30

Tyr?Ser?Ser?Ser?Met?Phe?Leu?Gly?Ile?Phe?Ile?Ala?Val?Asn?Tyr?Leu

35 40 45

Pro?Asp?Leu?Leu?Leu?Ile?Phe?Phe?Gly?Pro?Val?Ile?Asp?Arg?Val?Asn

50 55 60

Pro?Gln?Lys?Ile?Leu?Ile?Ile?Ser?Ile?Leu?Val?Gln?Leu?Ala?Val?Ala

65 70 75 80

Val?Ile?Phe?Leu?Leu?Leu?Leu?Asn?Gln?Ile?Ser?Phe?Trp?Val?Ile?Met

85 90 95

Ser?Leu?Val?Phe?Ile?Ser?Val?Met?Ala?Ser?Ser?Ile?Ser?Tyr?Val?Ile

100 105 110

Glu?Asp?Val?Leu?Ile?Pro?Gln?Val?Val?Glu?Tyr?Asp?Lys?Ile?Val?Phe

115 120 125

Ala?Asn?Ser?Leu?Phe?Ser?Ile?Ser?Tyr?Lys?Val?Leu?Asp?Ser?Ile?Phe

130 135 140

Asn?Ser?Phe?Ala?Ser?Phe?Leu?Gln?Val?Ala?Val?Gly?Phe?Ile?Leu?Leu

145 150 155 160

Val?Lys?Ile?Asp?Ile?Gly?Ile?Phe?Leu?Leu?Ala?Leu?Phe?Ile?Leu?Leu

165 170 175

Leu?Leu?Lys?Phe?Arg?Thr?Ser?Asn?Ala?Asn?Ile?Glu?Asn?Phe?Ser?Phe

180 185 190

Lys?Tyr?Tyr?Lys?Arg?Glu?Val?Leu?Gln?Gly?Thr?Lys?Phe?Ile?Leu?Asn

195 200 205

Asn?Lys?Leu?Leu?Phe?Lys?Thr?Ser?Ile?Ser?Leu?Thr?Leu?Ile?Asn?Phe

210 215 220

Phe?Tyr?Ser?Phe?Gln?Thr?Val?Val?Val?Pro?Ile?Phe?Ser?Ile?Arg?Tyr

225 230 235 240

Phe?Asp?Gly?Pro?Ile?Phe?Tyr?Gly?Ile?Phe?Leu?Thr?Ile?Ala?Gly?Leu

245 250 255

Gly?Gly?Ile?Leu?Gly?Asn?Met?Leu?Ala?Pro?Ile?Val?Ile?Lys?Tyr?Leu

260 265 270

Lys?Ser?Asn?Gln?Ile?Val?Gly?Val?Phe?Leu?Phe?Leu?Asn?Gly?Ser?Ser

275 280 285

Trp?Leu?Val?Ala?Ile?Val?Ile?Lys?Asp?Tyr?Thr?Leu?Ser?Leu?Ile?Leu

290 295 300

Phe?Phe?Val?Cys?Phe?Met?Ser?Lys?Gly?Val?Phe?Asn?Ile?Ile?Phe?Asn

305 310 315 320

Ser?Leu?Tyr?Gln?Gln?Ile?Pro?Pro?His?Gln?Leu?Leu?Gly?Arg?Val?Asn

325 330 335

Thr?Thr?Ile?Asp?Ser?Ile?Ile?Ser?Phe?Gly?Met?Pro?Ile?Gly?Ser?Leu

340 345 350

Val?Ala?Gly?Thr?Leu?Ile?Asp?Leu?Asn?Ile?Glu?Leu?Val?Leu?Ile?Ala

355 360 365

Ile?Ser?Ile?Pro?Tyr?Phe?Leu?Phe?Ser?Tyr?Ile?Phe?Tyr?Thr?Asp?Asn

370 375 380

Gly?Leu?Lys?Glu?Phe?Ser?Ile?Tyr

385 390

<210>143

<211>225

<212>PRT

＜213〉streptococcus pneumoniae

<400>143

Met?Met?Ser?Asn?Lys?Asn?Lys?Glu?Ile?Leu?Ile?Phe?Ala?Ile?Leu?Tyr

1 5 10 15

Thr?Val?Leu?Phe?Met?Phe?Asp?Gly?Val?Lys?Leu?Leu?Ala?Ser?Leu?Met

20 25 30

Pro?Ser?Ala?Ile?Ala?Asn?Tyr?Leu?Val?Tyr?Val?Val?Leu?Ala?Leu?Tyr

35 40 45

Gly?Ser?Phe?Leu?Phe?Lys?Asp?Arg?Leu?Ile?Gln?Gln?Trp?Lys?Glu?Ile

50 55 60

Arg?Lys?Thr?Lys?Arg?Lys?Phe?Phe?Phe?Gly?Val?Leu?Thr?Gly?Trp?Leu

65 70 75 80

Phe?Leu?Ile?Leu?Met?Thr?Val?Val?Phe?Glu?Phe?Val?Ser?Glu?Met?Leu

85 90 95

Lys?Gln?Phe?Val?Gly?Leu?Asp?Gly?Gln?Gly?Leu?Asn?Gln?Ser?Asn?Ile

100 105 110

Gln?Ser?Thr?Phe?Gln?Glu?Gln?Pro?Leu?Leu?Ile?Ala?Val?Phe?Ala?Cys

115 120 125

Val?Ile?Gly?Pro?Leu?Val?Glu?Glu?Leu?Phe?Phe?Arg?Gln?Val?Leu?Leu

130 135 140

His?Tyr?Leu?Gln?Glu?Arg?Leu?Ser?Gly?Leu?Leu?Ser?Ile?Ile?Leu?Val

145 150 155 160

Gly?Leu?Val?Phe?Ala?Leu?Thr?His?Met?His?Ser?Leu?Ala?Leu?Ser?Glu

165 170 175

Trp?Ile?Gly?Ala?Val?Gly?Tyr?Leu?Gly?Gly?Gly?Leu?Ala?Phe?Ser?Ile

180 185 190

Ile?Tyr?Val?Lys?Glu?Lys?Glu?Asn?Ile?Tyr?Tyr?Pro?Leu?Leu?Val?His

195 200 205

Met?Leu?Ser?Asn?Ser?Leu?Ser?Leu?Ile?Ile?Leu?Ala?Ile?Ser?Ile?Val

210 215 220

Lys

225

<210>144

<211>385

<212>PRT

＜213〉streptococcus pneumoniae

<400>144

Leu?Lys?Lys?Pro?Ile?Ile?Glu?Phe?Lys?Asn?Val?Ser?Lys?Val?Phe?Glu

1 5 10 15

Asp?Ser?Asn?Thr?Lys?Val?Leu?Lys?Asp?Ile?Asn?Phe?Glu?Leu?Glu?Glu

20 25 30

Gly?Lys?Phe?Tyr?Thr?Leu?Leu?Gly?Ala?Ser?Gly?Ser?Gly?Lys?Ser?Thr

35 40 45

Ile?Leu?Asn?Ile?Ile?Ala?Gly?Leu?Leu?Asp?Ala?Thr?Thr?Gly?Asp?Ile

50 55 60

Met?Leu?Asp?Gly?Val?Arg?Ile?Asn?Asp?Ile?Pro?Thr?Asn?Lys?Arg?Asp

65 70 75 80

Val?His?Thr?Val?Phe?Gln?Ser?Tyr?Ala?Leu?Phe?Pro?His?Met?Asn?Val

85 90 95

Phe?Glu?Asn?Val?Ala?Phe?Pro?Leu?Arg?Leu?Arg?Lys?Ile?Asp?Lys?Lys

100 105 110

Glu?Ile?Glu?Gln?Arg?Val?Ala?Glu?Val?Leu?Lys?Met?Val?Gln?Leu?Glu

115 120 125

Gly?Tyr?Glu?Lys?Arg?Ser?Ile?Arg?Lys?Leu?Ser?Gly?Gly?Gln?Arg?Gln

130 135 140

Arg?Val?Ala?Ile?Ala?Arg?Ala?Ile?Ile?Asn?Gln?Pro?Arg?Val?Val?Leu

145 150 155 160

Leu?Asp?Glu?Pro?Leu?Ser?Ala?Leu?Asp?Leu?Lys?Leu?Arg?Thr?Asp?Met

165 170 175

Gln?Tyr?Glu?Leu?Arg?Glu?Leu?Gln?Gln?Arg?Leu?Gly?Ile?Thr?Phe?Val

180 185 190

Phe?Val?Thr?His?Asp?Gln?Glu?Glu?Ala?Leu?Ala?Met?Ser?Asp?Trp?Ile

195 200 205

Phe?Val?Met?Asn?Asp?Gly?Glu?Ile?Val?Gln?Ser?Gly?Thr?Pro?Val?Asp

210 215 220

Ile?Tyr?Asp?Glu?Pro?Ile?Asn?His?Phe?Val?Ala?Thr?Phe?Ile?Gly?Glu

225 230 235 240

Ser?Asn?Ile?Leu?Pro?Gly?Thr?Met?Ile?Glu?Asp?Tyr?Leu?Val?Glu?Phe

245 250 255

Asn?Gly?Lys?Arg?Phe?Glu?Ala?Val?Asp?Gly?Gly?Met?Lys?Pro?Asn?Glu

260 265 270

Pro?Val?Glu?Val?Val?Ile?Arg?Pro?Glu?Asp?Leu?Arg?Ile?Thr?Leu?Pro

275 280 285

Glu?Glu?Gly?Lys?Leu?Gln?Val?Lys?Val?Asp?Thr?Gln?Leu?Phe?Arg?Gly

290 295 300

Val?His?Tyr?Glu?Ile?Ile?Ala?Tyr?Asp?Glu?Leu?Gly?Asn?Glu?Trp?Met

305 310 315 320

Ile?His?Ser?Thr?Arg?Lys?Ala?Ile?Val?Gly?Glu?Glu?Ile?Gly?Leu?Asp

325 330 335

Phe?Glu?Pro?Glu?Asp?Ile?His?Ile?Met?Arg?Leu?Asn?Glu?Thr?Glu?Glu

340 345 350

Glu?Phe?Asp?Ala?Arg?Ile?Glu?Glu?Tyr?Val?Glu?Ile?Glu?Glu?Gln?Glu

355 360 365

Ala?Gly?Leu?Ile?Asn?Ala?Ile?Glu?Glu?Glu?Arg?Asp?Glu?Glu?Asn?Lys

370 375 380

Leu

385

<210>145

<211>206

<212>PRT

＜213〉streptococcus pneumoniae

<400>145

Met?Lys?Ser?Met?Arg?Ile?Leu?Phe?Leu?Leu?Ala?Leu?Ile?Gln?Ile?Ser

1 5 10 15

Leu?Ser?Ser?Cys?Phe?Leu?Trp?Lys?Glu?Cys?Ile?Leu?Ser?Phe?Lys?Gln

20 25 30

Ser?Thr?Ala?Phe?Phe?Ile?Gly?Ser?Met?Val?Phe?Val?Ser?Gly?Ile?Cys

35 40 45

Ala?Gly?Val?Asn?Tyr?Leu?Tyr?Thr?Arg?Lys?Gln?Glu?Val?His?Ser?Val

50 55 60

Leu?Ala?Ser?Lys?Lys?Ser?Val?Lys?Leu?Phe?Tyr?Ser?Met?Leu?Leu?Leu

65 70 75 80

Ile?Asn?Leu?Leu?Gly?Ala?Val?Leu?Val?Leu?Ser?Asp?Asn?Leu?Phe?Ile

85 90 95

Lys?Asn?Thr?Leu?Gln?Gln?Glu?Leu?Val?Asp?Phe?Leu?Leu?Pro?Ser?Phe

100 105 110

Phe?Phe?Leu?Phe?Gly?Leu?Asp?Leu?Leu?Ile?Phe?Leu?Pro?Leu?Lys?Lys

115 120 125

Tyr?Val?Arg?Asp?Phe?Leu?Ala?Met?Leu?Asp?Arg?Lys?Lys?Thr?Val?Leu

130 135 140

Val?Thr?Ile?Leu?Ala?Thr?Leu?Leu?Phe?Leu?Arg?Asn?Pro?Met?Thr?Ile

145 150 155 160

Val?Ser?Leu?Leu?Ile?Tyr?Ile?Gly?Leu?Gly?Leu?Phe?Phe?Ala?Ala?Tyr

165 170 175

Leu?Val?Pro?Asn?Ser?Val?Lys?Lys?Glu?Val?Ser?Phe?Tyr?Gly?His?Ile

180 185 190

Phe?Arg?Asp?Leu?Val?Leu?Val?Ile?Val?Thr?Leu?Ile?Phe?Phe

195 200 205

<210>146

<211>338

<212>PRT

＜213〉streptococcus pneumoniae

<400>146

Met?Val?Lys?Lys?Ile?Ile?Gly?Met?Val?Leu?Ala?Leu?Leu?Ser?Val?Thr

1 5 10 15

Val?Val?Gly?Val?Gly?Val?Phe?Ala?Tyr?Thr?Ile?Tyr?Gln?Gln?Gly?Thr

20 25 30

Glu?Thr?Leu?Ala?Lys?Thr?Tyr?Lys?Lys?Ile?Gly?Glu?Glu?Thr?Lys?Val

35 40 45

Ile?Glu?Ala?Thr?Glu?Pro?Leu?Thr?Ile?Leu?Leu?Met?Gly?Val?Asp?Thr

50 55 60

Gly?Asn?Val?Glu?Arg?Thr?Glu?Thr?Trp?Val?Gly?Arg?Ser?Asp?Ser?Met

65 70 75 80

Ile?Leu?Met?Thr?Val?Asn?Pro?Lys?Thr?Lys?Lys?Thr?Thr?Met?Met?Ser

85 90 95

Leu?Glu?Arg?Asp?Ile?Leu?Thr?Arg?Ile?Glu?Ser?Gly?Asn?Gly?Gln?Ala

100 105 110

His?Glu?Ala?Lys?Leu?Asn?Ser?Ala?Tyr?Ala?Asp?Gly?Gly?Ala?Glu?Leu

115 120 125

Ala?Ile?Glu?Thr?Ile?Gln?Lys?Met?Met?Asn?Ile?His?Ile?Asp?Arg?Tyr

130 135 140

Val?Met?Val?Asn?Met?Arg?Gly?Leu?Gln?Lys?Leu?Val?Asp?Ala?Val?Gly

145 150 155 160

Gly?Ile?Thr?Val?Asn?Asn?Ile?Leu?Gly?Phe?Pro?Ile?Ser?Ile?Ser?Asp

165 170 175

Gln?Glu?Glu?Phe?Asn?Thr?Ile?Ser?Ile?Gly?Val?Gly?Glu?Gln?His?Ile

180 185 190

Gly?Gly?Glu?Glu?Ala?Leu?Val?Tyr?Ala?Arg?Met?Arg?Tyr?Gln?Asp?Pro

195 200 205

Glu?Gly?Asp?Tyr?Gly?Arg?Gln?Lys?Arg?Gln?Arg?Glu?Val?Ile?Gln?Lys

210 215 220

Val?Met?Glu?Lys?Ala?Leu?Ser?Leu?Asn?Ser?Ile?Gly?His?Tyr?Gln?Glu

225 230 235 240

Ile?Leu?Lys?Ala?Leu?Ser?Asp?Asn?Met?Gln?Thr?Asn?Ile?Asp?Leu?Ser

245 250 255

Ala?Lys?Ser?Ile?Pro?Asn?Leu?Leu?Gly?Tyr?Lys?Asp?Ser?Phe?Lys?Thr

260 265 270

Ile?Glu?Thr?Gln?Gln?Leu?Gln?Gly?Glu?Gly?Glu?Ile?Leu?Gln?Gly?Val

275 280 285

Ser?Tyr?Gln?Ile?Val?Ser?Arg?Ala?His?Met?Leu?Glu?Met?Gln?Asn?Leu

290 295 300

Leu?Arg?Arg?Ser?Leu?Gly?Gln?Glu?Glu?Val?Thr?Gln?Leu?Glu?Thr?Asn

305 310 315 320

Ala?Val?Leu?Phe?Glu?Asp?Leu?Phe?Gly?Arg?Ala?Pro?Val?Gly?Asp?Glu

325 330 335

Asp?Asn

<210>147

<211>331

<212>PRT

＜213〉streptococcus pneumoniae

<400>147

Met?Lys?Lys?Gln?Ala?Tyr?Val?Ile?Ile?Ala?Leu?Thr?Ser?Phe?Leu?Phe

1 5 10 15

Val?Phe?Phe?Phe?Ser?His?Ser?Leu?Leu?Glu?Ile?Leu?Asp?Phe?Asp?Trp

20 25 30

Ser?Ile?Phe?Leu?His?Asp?Val?Glu?Lys?Thr?Glu?Lys?Phe?Val?Phe?Leu

35 40 45

Leu?Leu?Val?Phe?Ser?Met?Ser?Met?Thr?Cys?Leu?Leu?Ala?Leu?Phe?Trp

50 55 60

Arg?Gly?Ile?Glu?Glu?Leu?Ser?Leu?Arg?Lys?Met?Gln?Ala?Asn?Leu?Lys

65 70 75 80

Arg?Leu?Leu?Ala?Gly?Gln?Glu?Val?Val?Gln?Val?Ala?Asp?Pro?Asp?Leu

85 90 95

Asp?Ala?Ser?Phe?Lys?Ser?Leu?Ser?Gly?Lys?Leu?Asn?Leu?Leu?Thr?Glu

100 105 110

Ala?Leu?Gln?Lys?Ala?Glu?Asn?Gln?Ser?Leu?Ala?Gln?Glu?Glu?Glu?Ile

115 120 125

Ile?Glu?Lys?Glu?Arg?Lys?Arg?Ile?Ala?Arg?Asp?Leu?His?Asp?Thr?Val

130 135 140

Ser?Gln?Glu?Leu?Phe?Ala?Ala?His?Met?Ile?Leu?Ser?Gly?Ile?Ser?Gln

145 150 155 160

Gln?Ala?Leu?Lys?Leu?Asp?Arg?Glu?Lys?Met?Gln?Thr?Gln?Leu?Gln?Ser

165 170 175

Val?Thr?Ala?Ile?Leu?Glu?Thr?Ala?Gln?Lys?Asp?Leu?Arg?Val?Leu?Leu

180 185 190

Leu?His?Leu?Arg?Pro?Val?Glu?Leu?Glu?Gln?Lys?Ser?Leu?Ile?Glu?Gly

195 200 205

Ile?Gln?Ile?Leu?Leu?Lys?Glu?Leu?Glu?Asp?Lys?Ser?Asp?Leu?Arg?Val

210 215 220

Ser?Leu?Lys?Gln?Asn?Met?Thr?Lys?Leu?Pro?Lys?Lys?Ile?Glu?Glu?His

225 230 235 240

Ile?Phe?Arg?Ile?Leu?Gln?Glu?Leu?Ile?Ser?Asn?Thr?Leu?Arg?His?Ala

245 250 255

Gln?Ala?Ser?Cys?Leu?Asp?Val?Tyr?Leu?Tyr?Gln?Thr?Asp?Val?Glu?Leu

260 265 270

Gln?Leu?Lys?Val?Val?Asp?Asn?Gly?Ile?Gly?Phe?Gln?Leu?Gly?Ser?Leu

275 280 285

Asp?Asp?Leu?Ser?Tyr?Gly?Leu?Arg?Asn?Ile?Lys?Glu?Arg?Val?Glu?Asp

290 295 300

Met?Ala?Gly?Thr?Val?Gln?Leu?Leu?Thr?Ala?Pro?Lys?Gln?Gly?Leu?Ala

305 310 315 320

Val?Asp?Ile?Arg?Ile?Pro?Leu?Leu?Asp?Lys?Glu

325 330

<210>148

<211>288

<212>PRT

＜213〉streptococcus pneumoniae

<400>148

Met?Ile?Val?Ser?Ile?Ile?Ser?Gln?Gly?Phe?Val?Trp?Ala?Ile?Leu?Gly

1 5 10 15

Leu?Gly?Ile?Phe?Met?Thr?Phe?Arg?Ile?Leu?Asn?Phe?Pro?Asp?Met?Thr

20 25 30

Thr?Glu?Gly?Ser?Phe?Pro?Leu?Gly?Gly?Ala?Val?Ala?Val?Thr?Leu?Ile

35 40 45

Thr?Lys?Gly?Val?Asn?Pro?Phe?Leu?Ala?Thr?Leu?Val?Ala?Val?Gly?Ala

50 55 60

Gly?Cys?Leu?Ala?Gly?Met?Ala?Ala?Gly?Leu?Leu?Tyr?Thr?Lys?Gly?Lys

65 70 75 80

Ile?Pro?Thr?Leu?Leu?Ser?Gly?Ile?Leu?Val?Met?Thr?Ser?Cys?His?Ser

85 90 95

Ile?Met?Leu?Leu?Ile?Met?Gly?Arg?Ala?Asn?Leu?Gly?Leu?Leu?Gly?Thr

100 105 110

Lys?Gln?Ile?Gln?Asp?Val?Leu?Pro?Phe?Asp?Ser?Asp?Leu?Asn?Gln?Leu

115 120 125

Leu?Thr?Gly?Leu?Ile?Phe?Val?Ser?Ile?Val?Ile?Ala?Leu?Met?Leu?Phe

130 135 140

Phe?Leu?Asp?Thr?Lys?Leu?Gly?Gln?Ala?Tyr?Ile?Ala?Thr?Gly?Asp?Asn

145 150 155 160

Pro?Asp?Met?Ala?Arg?Ser?Phe?GlyIle?His?Thr?Gly?Arg?Met?Glu?Leu

165 170 175

Met?Gly?Leu?Val?Leu?Ser?Asn?Gly?Val?Ile?Ala?Leu?Ala?Gly?Ala?Leu

180 185 190

Ile?Ala?Gln?Gln?Glu?Gly?Tyr?Ala?Asp?Val?Ser?Arg?Gly?Ile?Gly?Val

195 200 205

Ile?Val?Val?Gly?Leu?Ala?Ser?Leu?Ile?Ile?Gly?Glu?Val?Ile?Phe?Lys

210 215 220

Ser?Leu?Ser?Leu?Ala?Glu?Arg?Leu?Val?Thr?Ile?Val?Val?Gly?Ser?Ile

225 230 235 240

Ala?Tyr?Gln?Phe?Leu?Val?Trp?Ala?Val?Ile?Ala?Leu?Gly?Phe?Asn?Thr

245 250 255

Ser?Tyr?Leu?Arg?Leu?Tyr?Ser?Ala?LeuIle?Leu?Ala?Val?Cys?Leu?Met

260 265 270

Ile?Pro?Thr?Phe?Lys?Gln?Thr?Ile?Leu?Lys?Gly?Ala?Lys?Leu?Ser?Lys

275 280 285

<210>149

<211>355

<212>PRT

＜213〉streptococcus pneumoniae

<400>149

Met?Lys?Lys?Met?Lys?Val?Trp?Ser?Thr?Val?Leu?Ala?Thr?Gly?Val?Ala

1 5 10 15

Leu?Thr?Thr?Leu?Ala?Ala?Cys?Ser?Gly?Gly?Ser?Asn?Ser?Thr?Thr?Ala

20 25 30

Ser?Ser?Ser?Glu?Glu?Lys?Ala?Asp?Lys?Ser?Gln?Glu?Leu?Val?Ile?Tyr

35 40 45

Ser?Asn?Ser?Val?Ser?Asn?Gly?Arg?Gly?Asp?Trp?Leu?Thr?Ala?Lys?Ala

50 55 60

Lys?Glu?Ala?Gly?Phe?Asn?Ile?Lys?Met?Val?Asp?Ile?Ala?Gly?Ala?Gln

65 70 75 80

Leu?Ala?Asp?Arg?Val?Ile?Ala?Glu?Lys?Asn?Asn?Ala?Val?Ala?Asp?Met

85 90 95

Val?Phe?Gly?Ile?Gly?Ala?Val?Asp?Ser?Asn?Lys?Ile?Arg?Asp?Gln?Lys

100 105 110

Leu?Leu?Val?Gln?Tyr?Lys?Pro?Lys?Trp?Leu?Asp?LysIle?Asp?Gln?Ser

115 120 125

Leu?Ser?Asp?Lys?Asp?Asn?Tyr?Tyr?Asn?Pro?Val?Ile?Val?Gln?Pro?Leu

130 135 140

Val?Leu?Ile?Gly?Ala?Pro?Asp?Val?Lys?Glu?Met?Pro?Lys?Asp?Trp?Thr

145 150 155 160

Glu?Leu?Gly?Ser?Lys?Tyr?Lys?Gly?Lys?Tyr?Ser?Ile?Ser?Gly?Leu?Gln

165 170 175

Gly?Gly?Thr?Gly?Arg?Ala?Ile?Leu?Ala?Ser?Ile?Leu?Val?Arg?Tyr?Leu

180 185 190

Asp?Asp?Lys?Gly?Glu?Leu?Gly?Val?Ser?Glu?Lys?Gly?Trp?Glu?Val?Ala

195 200 205

Lys?Glu?Tyr?Leu?Lys?Asn?Ala?Tyr?Thr?Leu?Gln?Lys?Gly?Glu?Ser?Ser

210 215 220

Ile?Val?Lys?Met?Leu?Asp?Lys?Glu?Asp?Pro?Ile?Gln?Tyr?Gly?Met?Met

225 230 235 240

Trp?Gly?Ser?Gly?Ala?Leu?Val?Gly?Gln?Lys?Glu?Gln?Asn?Val?Val?Phe

245 250 255

Lys?Val?Met?Thr?Pro?Glu?Ile?Gly?Val?Pro?Phe?Val?Thr?Glu?Gln?Thr

260 265 270

Met?Val?Leu?Ser?Thr?Ser?Lys?Lys?Gln?Ala?Leu?Ala?Lys?Glu?Phe?Ile

275 280 285

Asp?Trp?Phe?Gly?Gln?Ser?Glu?Ile?Gln?Val?Glu?Tyr?Ser?Lys?Asn?Phe

290 295 300

Gly?Ser?Ile?Pro?Ala?Asn?Lys?Asp?Ala?Leu?Lys?Asp?Leu?Pro?Glu?Asp

305 310 315 320

Thr?Lys?Lys?Phe?Val?Asp?Gln?Val?Lys?Pro?Gln?Asn?Ile?Asp?Trp?Glu

325 330 335

Ala?Val?Gly?Lys?His?Leu?Asp?Glu?Trp?Val?Glu?Lys?Ala?Glu?Leu?Glu

340 345 350

Tyr?Val?Gln

355

<210>150

<211>336

<212>PRT

＜213〉streptococcus pneumoniae

<400>150

Met?Ile?Lys?Phe?Asp?Asn?Ile?Gln?Ile?Lys?Tyr?Gly?Asp?Phe?Val?Ala

1 5 10 15

Ile?Asp?Asn?Leu?Asn?Leu?Asp?Ile?His?Glu?Gly?Glu?Phe?Phe?Thr?Phe

20 25 30

Leu?Gly?Pro?Ser?Gly?Cys?Gly?Lys?Ser?Thr?Thr?Leu?Arg?Ala?Leu?Val

35 40 45

Gly?Phe?Leu?Asp?Pro?Ser?Ser?Gly?Ser?Ile?Glu?Val?Asn?Gly?Thr?Asp

50 55 60

Val?Thr?His?Leu?Glu?Pro?Glu?Lys?Arg?Gly?Ile?Gly?Ile?Val?Phe?Gln

65 70 75 80

Ser?Tyr?Ala?Leu?Phe?Pro?Thr?Met?Thr?Val?Phe?Asp?Asn?Ile?Ala?Phe

85 90 95

Gly?Leu?Lys?Val?Lys?Lys?Val?Ala?Pro?Asp?Val?Ile?Lys?Ala?Lys?Val

100 105 110

Ser?Ala?Val?Ala?Ala?Lys?Ile?Lys?Ile?Ser?Asp?Gln?Gln?Leu?Gln?Arg

115 120 125

Asn?Val?Ser?Glu?Leu?Ser?Gly?Gly?Gln?Gln?Gln?Arg?Val?Ala?Leu?Ala

130 135 140

Arg?Ala?Leu?Val?Leu?Glu?Pro?Lys?Ile?Leu?Cys?Leu?Asp?Glu?Pro?Leu

145 150 155 160

Ser?Asn?Leu?Asp?Ala?Lys?Leu?Arg?Val?Asp?Leu?Arg?Lys?Glu?Leu?Lys

165 170 175

Arg?Leu?Gln?Lys?Glu?Leu?Gly?Ile?Thr?Thr?Leu?Tyr?Val?Thr?His?Asp

180 185 190

Gln?Glu?Glu?Ala?Leu?Thr?Leu?Ser?Asp?Arg?Ile?Ala?Val?Phe?Asn?Asn

195 200 205

Gly?Tyr?Ile?Glu?Gln?Val?Gly?Thr?Pro?Val?Glu?Ile?Tyr?His?Asn?Ser

210 215 220

Gln?Thr?Glu?Phe?Val?Cys?Asp?Phe?Ile?Gly?Asp?Ile?Asn?Val?Leu?Thr

225 230 235 240

Asp?Glu?Thr?Val?His?Glu?Val?Leu?Leu?Lys?Asn?Thr?Ser?Val?Phe?Leu

245 250 255

Glu?Asp?Lys?Lys?Gly?Tyr?Ile?Arg?Leu?Glu?Lys?ValArg?Phe?Asn?Arg

260 265 270

Glu?Thr?Glu?Gln?Asp?Phe?Ile?Leu?Lys?Gly?Thr?Ile?Ile?Asp?Val?Glu

275 280 285

Phe?Ser?Gly?Val?Thr?Ile?His?Tyr?Thr?Ile?Lys?Val?Ser?Glu?Ser?Gln

290 295 300

Ile?Leu?Asn?Val?Thr?Ser?Ile?Asp?Ser?Gln?Ala?Ala?Ile?Arg?Ser?Val

305 310 315 320

Gly?Glu?Ser?Val?Glu?Leu?Phe?Ile?Thr?Pro?Ser?Asp?Val?Leu?Gln?Phe

325330335

<210>151

<211>563

<212>PRT

＜213〉streptococcus pneumoniae

<400>151

Met?Arg?His?Lys?Leu?Asn?Leu?Lys?Asp?Trp?Leu?Ile?Arg?Leu?Gly?Leu

1 5 10 15

Ile?Trp?Phe?Leu?Val?Thr?Phe?Ile?Ile?Tyr?Pro?Asn?Phe?Asp?Leu?Val

20 25 30

Val?Asn?Val?Phe?Val?Lys?Gly?Gly?Glu?Phe?Ser?Leu?Asp?Ala?Val?His

35 40 45

Arg?Val?Leu?Lys?Ser?Gln?Arg?Ala?Leu?Gln?Ser?Ile?Met?Asn?Ser?Phe

50 55 60

Lys?Leu?Ala?Phe?Ser?Leu?Ile?Ile?Thr?Val?Asn?Val?Val?Gly?Ile?Leu

65 70 75 80

Cys?Val?Leu?Phe?Thr?Glu?Tyr?Phe?Asp?Ile?Lys?Gly?Ala?Lys?Ile?Leu

85 90 95

Lys?Leu?Gly?Tyr?Met?Thr?Ser?Leu?Ile?Tyr?Gly?Gly?Val?Val?Leu?Ala

100 105 110

Thr?Gly?Tyr?Lys?Phe?Val?Tyr?Gly?Pro?Tyr?Gly?Leu?Ile?Thr?Lys?Phe

115 120 125

Leu?Gln?Asn?Val?Ile?Pro?Ser?Leu?Asp?Pro?Asn?Trp?Phe?Ile?Gly?Tyr

130 135 140

Gly?Ala?Val?Leu?Phe?Ile?Met?Thr?Phe?Ser?Gly?Thr?Ala?Asn?His?Thr

145 150 155 160

Leu?Phe?Leu?Thr?Asn?Thr?Ile?Arg?Ser?Val?Asp?Tyr?His?Thr?Ile?Glu

165 170 175

Ala?Ala?Arg?Asn?Met?Gly?Ala?Lys?Pro?Phe?Thr?Val?Phe?Arg?Lys?Val

180 185 190

Val?Leu?Pro?Thr?Leu?Ile?Pro?Thr?Leu?Phe?Ala?Leu?Thr?Ile?Met?Val

195 200 205

Phe?Leu?Ser?Gly?Leu?Ser?Ala?Val?Ala?Ala?Pro?Met?Ile?Val?Gly?Gly

210 215 220

Lys?Glu?Phe?Gln?Thr?Ile?Asn?Pro?Met?Ile?Ile?Thr?Phe?Ala?Gly?Met

225 230 235 240

Gly?Asn?Ser?Arg?Asp?Leu?Ala?Ala?Leu?Leu?Ala?Ile?Ile?Leu?Gly?Ile

245 250 255

Ala?Thr?Thr?Ile?Leu?Leu?Thr?Ile?Met?Asn?Lys?Ile?Glu?Lys?Gly?Gly

260 265 270

Asn?Tyr?Ile?Ser?Ile?Ser?Lys?Thr?Lys?Ala?Pro?Leu?Lys?Lys?Gln?Lys

2752 80 285

Ile?Ala?Ser?Lys?Pro?Trp?Asn?Ile?Ile?Ala?His?Ile?Val?Ala?Tyr?Gly

290 295 300

Leu?Phe?Thr?Val?Phe?Met?Leu?Pro?Leu?Ile?Phe?Ile?Val?Leu?Tyr?Ser

305 310 315 320

Phe?Thr?Asp?Pro?Val?Ala?Ile?Gln?Thr?Gly?Asn?Leu?Thr?Leu?Ser?Asn

325 330 335

Phe?Thr?Leu?Glu?Asn?Tyr?Arg?Leu?Phe?Phe?Ser?Asn?Ser?Ala?Ala?Phe

340 345 350

Ser?Pro?Phe?Leu?Val?Ser?Phe?Ile?Tyr?Ser?Ile?Ile?Ala?Ala?Thr?Thr

355 360 365

Ala?Thr?Ile?Leu?Ala?Val?Val?Phe?Ala?Arg?Val?Val?Arg?Lys?His?Lys

370 375 380

Ser?Arg?Phe?Asp?Phe?Leu?Phe?Glu?Tyr?Gly?Ala?Leu?Leu?Pro?Trp?Leu

385 390 395 400

Leu?Pro?Ser?Thr?Leu?Leu?Ala?Val?Ser?Leu?Leu?Phe?Thr?Phe?Asn?Gln

405 410 415

Pro?Gln?Phe?Leu?Val?Leu?Asn?Gln?Ile?Leu?Val?Gly?Ser?Leu?Val?Ile

420 425 430

Leu?Leu?Ile?Ala?Tyr?Ile?Val?Val?Lys?Ile?Pro?Phe?Ser?Tyr?Arg?Met

435 440 445

Val?Arg?Ala?Ile?Leu?Phe?Ser?Val?Asp?Asp?Glu?Met?Glu?Asp?Ala?Ala

450 455 460

Arg?Ser?Met?Gly?Ala?Ser?Pro?Phe?Tyr?Thr?Met?Met?Lys?Val?Ile?Ile

465 470 475 480

Pro?Phe?Ile?Leu?Pro?Val?Val?Leu?Ser?Val?Ile?Ala?Leu?Asn?Phe?Asn

485 490 495

Ser?Leu?Leu?Thr?Asp?Phe?Asp?Leu?Ser?Val?Phe?Leu?Tyr?His?Pro?Leu

500 505 510

Ala?Gln?Pro?Leu?Gly?Ile?Thr?Ile?Arg?Ser?Ala?Gly?Asp?Glu?Thr?Ala

515 520 525

Thr?Ser?Asn?Ala?Gln?Ala?Leu?Val?Phe?Val?Tyr?Thr?Ile?Val?Leu?Met

530 535 540

Ile?Ile?Ser?Gly?Thr?Val?Leu?Tyr?Phe?Thr?Gln?Arg?Pro?Gly?Arg?Lys

545 550 555 560

Val?Arg?Lys

<210>152

<211>443

<212>PRT

＜213〉streptococcus pneumoniae

<400>152

Met?Ile?Lys?Asn?Pro?Lys?Leu?Leu?Thr?Lys?Ser?Phe?Leu?Arg?Ser?Phe

1 5 10 15

Ala?Ile?Leu?Gly?Gly?Val?Gly?Leu?Val?Ile?His?Ile?Ala?Ile?Tyr?Leu

20 25 30

Thr?Phe?Pro?Phe?Tyr?Tyr?Ile?Gln?Leu?Glu?Gly?Glu?Lys?Phe?Asn?Glu

35 40 45

Ser?Ala?Arg?Val?Phe?Thr?Glu?Tyr?Leu?Lys?Thr?Lys?Thr?Ser?Asp?Glu

50 55 60

Ile?Pro?Ser?Leu?Leu?Gln?Ser?Tyr?Ser?Lys?Ser?Leu?Thr?Ile?Ser?Ala

65 70 75 80

His?Leu?Lys?Arg?Asp?Ile?Val?Asp?Lys?Arg?Leu?Pro?Leu?Val?His?Asp

85 90 95

Leu?Asp?Ile?Lys?Asp?Gly?Lys?Leu?Ser?Asn?Tyr?Ile?Val?Met?Leu?Asp

100 105 110

Met?Ser?Val?Ser?Thr?Ala?Asp?Gly?Lys?Gln?Val?Thr?Val?Gln?Phe?Val

115 120 125

His?Gly?Val?Asp?Val?Tyr?Lys?Glu?Ala?Lys?Asn?Ile?Leu?Leu?Leu?Tyr

130 135 140

Leu?Pro?Tyr?Thr?Phe?Leu?Val?Thr?Ile?Ala?Phe?Ser?Phe?Val?Phe?Ser

145 150 155 160

Tyr?Phe?Tyr?Thr?Lys?Arg?Leu?Leu?Asn?Pro?Leu?Phe?Tyr?Ile?Ser?Glu

165 170 175

Val?Thr?Ser?Lys?Met?Gln?Asp?Leu?Asp?Asp?Asn?Ile?Arg?Phe?Asp?Glu

180 185 190

Ser?Arg?Lys?Asp?Glu?Val?Gly?Glu?Val?Gly?Lys?Gln?Ile?Asn?Gly?Met

195 200 205

Tyr?Glu?His?Leu?Leu?Lys?Val?Ile?Tyr?Glu?Leu?Glu?Ser?Arg?Asn?Glu

210 215 220

Gln?Ile?Val?Lys?Leu?Gln?Asn?Gln?Lys?Val?Ser?Phe?Val?Arg?Gly?Ala

225 230 235 240

Ser?His?Glu?Leu?Lys?Thr?Pro?Leu?Ala?Ser?Leu?Arg?Ile?Ile?Leu?Glu

245 250 255

Asn?Met?Gln?His?Asn?Ile?Gly?Asp?Tyr?Lys?Asp?His?Pro?Lys?Tyr?Ile

260 265 270

Ala?Lys?Ser?Ile?Asn?Lys?Ile?Asp?Gln?Met?Ser?His?Leu?Leu?Glu?Glu

275 280 285

Val?Leu?Glu?Ser?Ser?Lys?Phe?Gln?Glu?Trp?Thr?Glu?Cys?Arg?Glu?Thr

290 295 300

Leu?Thr?Val?Lys?Pro?Val?Leu?Val?Asp?Ile?Leu?Ser?Arg?Tyr?Gln?Glu

305 310 315 320

Leu?Ala?His?Ser?Ile?Gly?Val?Thr?Ile?Glu?Asn?Gln?Leu?Thr?Asp?Ala

325 330 335

Thr?Arg?Val?Val?Met?Ser?Leu?Arg?Ala?Leu?Asp?Lys?Val?Leu?Thr?Asn

340 345 350

Leu?Ile?Ser?Asn?Ala?Ile?Lys?Tyr?Ser?Asp?Lys?Asn?Gly?Arg?Val?Ile

355 360 365

Ile?Ser?Glu?Gln?Asp?Gly?Tyr?Leu?Ser?Ile?Lys?Asn?Thr?Cys?Ala?Pro

370 375 380

Leu?Ser?Asp?Gln?Glu?Leu?Glu?His?Leu?Phe?Asp?Ile?Phe?Tyr?His?Ser

385 390 395 400

Gln?Ile?Val?Thr?Asp?Lys?Asp?Glu?Ser?Ser?Gly?Leu?Gly?Leu?Tyr?Ile

405 410 415

Val?Asn?Asn?Ile?Leu?Glu?Ser?Tyr?Gln?Met?Asp?Tyr?Ser?Phe?Leu?Pro

420 425 430

Tyr?Glu?His?Gly?Met?Glu?Phe?Lys?Ile?Ser?Leu

435 440

<210>153

<211>290

<212>PRT

＜213〉streptococcus pneumoniae

<400>153

Met?Asp?Lys?Ile?Ile?Lys?Thr?Ile?Ser?Glu?Ser?GlyAla?Phe?Arg?Ala

1 5 10 15

Phe?Val?Leu?Asp?Ser?Thr?Glu?Thr?Val?Arg?Thr?Ala?Gln?Glu?Lys?His

20 25 30

Gln?Thr?Gln?Ala?Ser?Ser?Thr?Val?Ala?Leu?Gly?Arg?Thr?Leu?Ile?Ala

35 40 45

Ser?Gln?Ile?Leu?Ala?Ala?Asn?Glu?Lys?Gly?Asn?Thr?Lys?Leu?Thr?Val

50 55 60

Lys?Val?Leu?Gly?Ser?Ser?Ser?Leu?Gly?Ala?Ile?Ile?Thr?Val?Ala?Asp

65 70 75 80

Thr?Lys?Gly?Asn?Val?Lys?Gly?Tyr?Val?Gln?Asn?Pro?Gly?Val?Asp?Ile

85 90 95

Lys?Lys?Thr?Ala?Thr?Gly?Glu?Val?Leu?Val?Gly?Pro?Phe?Val?Gly?Asn

100 105 110

Gly?Gln?Phe?Leu?Val?Ile?Thr?Asp?Tyr?Gly?Thr?Gly?Asn?Pro?Tyr?Asn

115 120 125

Ser?Ile?Thr?Pro?Leu?Ile?Ser?Gly?Glu?Ile?Gly?Glu?Asp?Leu?Ala?Phe

130 135 140

Tyr?Leu?Thr?Glu?Ser?Gln?Gln?Thr?Pro?Ser?Ala?Val?Gly?Leu?Asn?Val

145 150 155 160

Leu?Leu?Asp?Glu?Glu?Asp?Lys?Val?Lys?Val?Ala?Gly?Gly?Phe?Leu?Val

165 170 175

Gln?Val?Leu?Pro?Gly?Ala?Lys?Lys?Glu?Glu?Ile?Ala?Arg?Phe?Glu?Lys

180 185 190

Arg?Ile?Gln?Glu?Met?Pro?Ala?Ile?Ser?Thr?Leu?Leu?Glu?Ser?Asp?Asp

195 200 205

His?Ile?Glu?Ala?Leu?Leu?Lys?Ala?Ile?Tyr?Gly?Asp?Glu?Ala?Tyr?Lys

210 215 220

Arg?Leu?Ser?Glu?Glu?Glu?Ile?Arg?Phe?Gln?Cys?Asp?Cys?Ser?His?Glu

225 230 235 240

Arg?Phe?Met?Asn?Ala?Leu?Ala?Ser?Leu?Pro?Ser?Ser?Asp?Leu?Gln?Glu

245 250 255

Met?Lys?Glu?Glu?Asp?His?Gly?Ala?Glu?Ile?Thr?Cys?Gln?Phe?Cys?Gln

260 265 270

Thr?Thr?Tyr?Asn?Phe?Asp?Glu?Lys?Asp?Leu?Glu?Glu?Leu?Ile?Arg?Asp

275 280 285

Lys?Ser

290

<210>154

<211>152

<212>PRT

＜213〉streptococcus pneumoniae

<400>154

Met?Lys?Ser?Ile?Thr?Lys?Lys?Ile?Lys?Ala?Thr?LeuAla?Gly?Val?Ala

1 5 10 15

Ala?Leu?Phe?Ala?Val?Phe?Ala?Pro?Ser?Phe?Val?Ser?Ala?Gln?Glu?Ser

20 25 30

Ser?Thr?Tyr?Thr?Val?Lys?Glu?Gly?Asp?Thr?Leu?Ser?Glu?Ile?Ala?Glu

35 40 45

Thr?His?Asn?Thr?Thr?Val?Glu?Lys?Leu?Ala?Glu?Asn?Asn?His?Ile?Asp

50 55 60

Asn?Ile?His?Leu?Ile?Tyr?Val?Asp?Gln?Glu?Leu?Val?Ile?Asp?Gly?Pro

65 70 75 80

Val?Ala?Pro?Val?Ala?Thr?Pro?Ala?Pro?Ala?Thr?Tyr?Ala?Ala?Pro?Ala

85 90 95

Ala?Gln?Asp?Glu?Thr?Val?Ser?Ala?Pro?Val?Ala?Glu?Thr?Pro?Val?Val

100 105 110

Ser?Glu?Thr?Val?Val?Ser?Thr?Val?Ser?Gly?Ser?Glu?Ala?Glu?Ala?Lys

115 120 125

Glu?Trp?Ile?Ala?Gln?Lys?Glu?Ser?Gly?Gly?Ser?Ile?Gln?Leu?Gln?Met

130 135 140

Asp?Val?Ile?Ser?Asp?Val?Thr?Asn

145 150

<210>155

<211>677

<212>PRT

＜213〉streptococcus pneumoniae

<400>155

Met?Asn?Leu?Gly?Glu?Phe?Trp?Tyr?Asn?Lys?Ile?Asn?Lys?Asn?Arg?Gly

1 5 10 15

Arg?Arg?Leu?Met?Lys?Lys?Val?Arg?Phe?Ile?Phe?Leu?Ala?Leu?Leu?Phe

20 25 30

Phe?Leu?Ala?Ser?Pro?Glu?Gly?Ala?Met?Ala?Ser?Asp?Gly?Thr?Trp?Gln

35 40 45

Gly?Lys?Gln?Tyr?Leu?Lys?Glu?Asp?Gly?Ser?Gln?Ala?Ala?Asn?Glu?Trp

50 55 60

Val?Phe?Asp?Thr?His?Tyr?Gln?Ser?Trp?Phe?Tyr?Ile?Lys?Ala?Asp?Ala

65 70 75 80

Asn?Tyr?Ala?Glu?Asn?Glu?Trp?Leu?Lys?Gln?Gly?Asp?Asp?Tyr?Phe?Tyr

85 90 95

Leu?Lys?Ser?Gly?Gly?Tyr?Met?Ala?Lys?Ser?Glu?Trp?Val?Glu?Asp?Lys

100 105 110

Gly?Ala?Phe?Tyr?Tyr?Leu?Asp?Gln?Asp?Gly?Lys?Met?Lys?Arg?Asn?Ala

115 120 125

Trp?Val?Gly?Thr?Ser?Tyr?Val?Gly?Ala?Thr?Gly?Ala?Lys?Val?Ile?Glu

130 135 140

Asp?Trp?Val?Tyr?Asp?Ser?Gln?Tyr?Asp?Ala?Trp?Phe?Tyr?Ile?Lys?Ala

145 150 155 160

Asp?Gly?Gln?His?Ala?Glu?Lys?Glu?Trp?Leu?Gln?Ile?Lys?Gly?Lys?Asp

165 170 175

Tyr?Tyr?Phe?Lys?Ser?Gly?Gly?Tyr?Leu?Leu?Thr?Ser?Gln?Trp?Ile?Asn

180 185 190

Gln?Ala?Tyr?Val?Asn?Ala?Ser?Gly?Ala?Lys?Val?Gln?Gln?Gly?Trp?Leu

195 200 205

Phe?Asp?Lys?Gln?Tyr?Gln?Ser?Trp?Phe?Tyr?Ile?Lys?Glu?Asn?Gly?Asn

210 215 220

Tyr?Ala?Asp?Lys?Glu?Trp?Ile?Phe?Glu?Asn?Gly?His?Tyr?Tyr?Tyr?Leu

225 230 235 240

Lys?Ser?Gly?Gly?Tyr?Met?Ala?Ala?Asn?Glu?Trp?Ile?Trp?Asp?Lys?Glu

245 250 255

Ser?Trp?Phe?Tyr?Leu?Lys?Phe?Asp?Gly?Lys?Met?Ala?Glu?Lys?Glu?Trp

260 265 270

Val?Tyr?Asp?Ser?His?Ser?Gln?Ala?Trp?Tyr?Tyr?Phe?Lys?Ser?Gly?Gly

275 280 285

Tyr?Met?Thr?Ala?Asn?Glu?Trp?Ile?Trp?Asp?Lys?Glu?Ser?Trp?Phe?Tyr

290 295 300

Leu?Lys?Ser?Asp?Gly?Lys?Ile?Ala?Glu?Lys?Glu?Trp?Val?Tyr?Asp?Ser

305 310 315 320

His?Ser?Gln?Ala?Trp?Tyr?Tyr?Phe?Lys?Ser?Gly?Gly?Tyr?Met?Thr?Ala

325 330 335

Asn?Glu?Trp?Ile?Trp?Asp?Lys?Glu?Ser?Trp?Phe?Tyr?Leu?Lys?Ser?Asp

340 345 350

Gly?Lys?Ile?Ala?Glu?Lys?Glu?Trp?Val?Tyr?Asp?Ser?His?Ser?Gln?Ala

355 360 365

Trp?Tyr?Tyr?Phe?Lys?Ser?Gly?Gly?Tyr?Met?Ala?Lys?Asn?Glu?Thr?Val

370 375 380

Asp?Gly?Tyr?Gln?Leu?Gly?Ser?Asp?Gly?Lys?Trp?Leu?Gly?Gly?Lys?Thr

385 390 395 400

Thr?Asn?Glu?Asn?Ala?Ala?Tyr?Tyr?Gln?Val?Val?Pro?Val?Thr?Ala?Asn

405 410 415

Val?Tyr?Asp?Ser?Asp?Gly?Glu?Lys?Leu?Ser?Tyr?Ile?Ser?Gln?Gly?Ser

420 425 430

Val?Val?Trp?Leu?Asp?Lys?Asp?Arg?Lys?Ser?Asp?Asp?Lys?Arg?Leu?Ala

435 440 445

Ile?Thr?Ile?Ser?Gly?Leu?Ser?Gly?Tyr?Met?Lys?Thr?Glu?Asp?Leu?Gln

450 455 460

Ala?Leu?Asp?Ala?Ser?Lys?Asp?Phe?Ile?Pro?Tyr?Tyr?Glu?Ser?Asp?Gly

465 470 475 480

His?Arg?Phe?Tyr?His?Tyr?Val?Ala?Gln?Asn?Ala?Ser?Ile?Pro?Val?Ala

485 490 495

Ser?His?Leu?Ser?Asp?Met?Glu?Val?Gly?Lys?Lys?Tyr?Tyr?Ser?Ala?Asp

500 505 510

Gly?Leu?His?Phe?Asp?Gly?Phe?Lys?Leu?Glu?Asn?Pro?Phe?Leu?Phe?Lys

515 520 525

Asp?Leu?Thr?Glu?Ala?Thr?Asn?Tyr?Ser?Ala?Glu?Glu?Leu?Asp?Lys?Val

530 535 540

Phe?Ser?Leu?Leu?Asn?Ile?Asn?Asn?Ser?Leu?Leu?Glu?Asn?Lys?Gly?Ala

545 550 555 560

Thr?Phe?Lys?Glu?Ala?Glu?Glu?His?Tyr?His?Ile?Asn?Ala?Leu?Tyr?Leu

565 570 575

Leu?Ala?His?Ser?Ala?Leu?Glu?Ser?Asn?Trp?Gly?Arg?Ser?Lys?Ile?Ala

580 585 590

Lys?Asp?Lys?Asn?Asn?Phe?Phe?Gly?Ile?Thr?Ala?Tyr?Asp?Thr?Thr?Pro

595 600 605

Tyr?Leu?Ser?Ala?Lys?Thr?Phe?Asp?Asp?Val?Asp?Lys?Gly?Ile?Leu?Gly

610 615 620

Ala?Thr?Lys?Trp?Ile?Lys?Glu?Asn?Tyr?Ile?Asp?Arg?Gly?Arg?Thr?Phe

625 630 635 640

Leu?Gly?Asn?Lys?Ala?Ser?Gly?Met?Asn?Val?Glu?Tyr?Ala?Ser?Asp?Pro

645 650 655

Tyr?Trp?Gly?Glu?Lys?Ile?Ala?Ser?Val?Met?Met?Lys?Ile?Asn?Glu?Lys

660 665 670

Leu?Gly?Gly?Lys?Asp

675

<210>156

<211>309

<212>PRT

＜213〉streptococcus pneumoniae

<400>156

Met?Lys?Lys?Leu?Gly?Thr?Leu?Leu?Val?Leu?Phe?Leu?Ser?Ala?Ile?Ile

1 5 10 15

Leu?Val?Ala?Cys?Ala?Ser?Gly?Lys?Lys?Asp?Thr?Thr?Ser?Gly?Gln?Lys

20 25 30

Leu?Lys?Val?Val?Ala?Thr?Asn?Ser?Ile?Ile?Ala?Asp?Ile?Thr?Lys?Asn

35 40 45

Ile?Ala?Gly?Asp?Lys?Ile?Asp?Leu?His?Ser?Ile?Val?Pro?Ile?Gly?Gln

50 55 60

Asp?Pro?His?Glu?Tyr?Glu?Pro?Leu?Pro?Glu?Asp?Val?Lys?Lys?Thr?Ser

65 70 75 80

Glu?Ala?Asn?Leu?Ile?Phe?Tyr?Asn?Gly?Ile?Asn?Leu?Glu?Thr?Gly?Gly

85 90 95

Asn?Ala?Trp?Phe?Thr?Lys?Leu?Val?Glu?Asn?Ala?Lys?Lys?Thr?Glu?Asn

100 105 110

Lys?Asp?Tyr?Phe?Ala?Val?Ser?Asp?Gly?Val?Asp?Val?Ile?Tyr?Leu?Glu

115 120 125

Gly?Gln?Asn?Glu?Lys?Gly?Lys?Glu?Asp?Pro?His?Ala?Trp?Leu?Asn?Leu

130 135 140

Glu?Asn?Gly?Ile?Ile?Phe?Ala?Lys?Asn?Ile?Ala?Lys?Gln?Leu?Ser?Ala

145 150 155 160

Lys?Asp?Pro?Asn?Asn?Lys?Glu?Phe?Tyr?Glu?Lys?Asn?Leu?Lys?Glu?Tyr

165 170 175

Thr?Asp?Lys?Leu?Asp?Lys?Leu?Asp?Lys?Glu?Ser?Lys?Asp?Lys?Phe?Asn

180 185 190

Lys?Ile?Pro?Ala?Glu?Lys?Lys?Leu?Ile?Val?Thr?Ser?Glu?Gly?Ala?Phe

195 200 205

Lys?Tyr?Phe?Ser?Lys?Ala?Tyr?Gly?Val?Pro?Ser?Ala?Tyr?Ile?Trp?Glu

210 215 220

Ile?Asn?Thr?Glu?Glu?Glu?Gly?Thr?Pro?Glu?Gln?Ile?Lys?Thr?Leu?Val

225 230 235 240

Glu?Lys?Leu?Arg?Gln?Thr?Lys?Val?Pro?Ser?Leu?Phe?Val?Glu?Ser?Ser

245 250 255

Val?Asp?Asp?Arg?Pro?Met?Lys?Thr?Val?Ser?Gln?Asp?Thr?Asn?Ile?Pro

260 265 270

Ile?Tyr?Ala?Gln?Ile?Phe?Thr?Asp?Ser?Ile?Ala?Glu?Gln?Gly?Lys?Glu

275 280 285

Gly?Asp?Ser?Tyr?Tyr?Ser?Met?Met?Lys?Tyr?Asn?Leu?Asp?Lys?Ile?Ala

290 295 300

Glu?Gly?Leu?Ala?Lys

305

<210>157

<211>419

<212>PRT

＜213〉streptococcus pneumoniae

<400>157

Met?Glu?Trp?Tyr?Lys?Lys?Ile?Gly?Leu?Leu?Ala?Thr?Thr?Gly?Leu?Ala

1 5 10 15

Leu?Phe?Gly?Leu?Gly?Ala?Cys?Ser?Asn?Tyr?Gly?Lys?Ser?Ala?Asp?Gly

20 25 30

Thr?Val?Thr?Ile?Glu?Tyr?Phe?Asn?Gln?Lys?Lys?Glu?Met?Thr?Lys?Thr

35 40 45

Leu?Glu?Glu?Ile?Thr?Arg?Asp?Phe?Glu?Lys?Glu?Asn?Pro?Lys?Ile?Lys

50 55 60

Val?Lys?Val?Val?Asn?Val?Pro?Asn?Ala?Gly?Glu?Val?Leu?Lys?Thr?Arg

65 70 75 80

Val?Leu?Ala?Gly?Asp?Val?Pro?Asp?Val?Val?Asn?Ile?Tyr?Pro?Gln?Ser

85 90 95

Ile?Glu?Leu?Gln?Glu?Trp?Ala?Lys?Ala?Gly?Val?Phe?Glu?Asp?Leu?Ser

100 105 110

Asn?Lys?Asp?Tyr?Leu?Lys?Arg?Val?Lys?Asn?Gly?Tyr?Ala?Glu?Lys?Tyr

115 120 125

Ala?Val?Asn?Glu?Lys?Val?Tyr?Asn?Val?Pro?Phe?Thr?Ala?Asn?Ala?Tyr

130 135 140

Gly?Ile?Tyr?Tyr?Asn?Lys?Asp?Lys?Phe?Glu?Glu?Leu?Gly?Leu?Lys?Val

145 150 155 160

Pro?Glu?Thr?Trp?Asp?Glu?Phe?Glu?Gln?Leu?Val?Lys?Asp?Ile?Val?Ala

165 170 175

Lys?Gly?Gln?Thr?Pro?Phe?Gly?Ile?Ala?Gly?Ala?Asp?Ala?Trp?Thr?Leu

180 185 190

Asn?Gly?Tyr?Asn?Gln?Leu?Ala?Phe?Ala?Thr?Ala?Thr?Gly?Gly?Gly?Lys

195 200 205

Glu?Ala?Asn?Gln?Tyr?Leu?Arg?Tyr?Ser?Gln?Pro?Asn?Ala?Ile?Lys?Leu

210 215 220

Ser?Asp?Pro?Ile?Met?Lys?Asp?Asp?Ile?Lys?Val?Met?Asp?Ile?Leu?Arg

225 230 235 240

Ile?Asn?Gly?Ser?Lys?Gln?Lys?Asn?Trp?Glu?Gly?Ala?Gly?Tyr?Thr?Asp

245 250 255

Val?Ile?Gly?Ala?Phe?Ala?Arg?Gly?Asp?Val?Leu?Met?Thr?Pro?Asn?Gly

260 265 270

Ser?Trp?Ala?Ile?Thr?Ala?Ile?Asn?Glu?Gln?Lys?Pro?Asn?Phe?Lys?Ile

275 280 285

Gly?Thr?Phe?MetIle?Pro?Gly?Lys?Glu?Lys?Gly?Gln?Ser?Leu?Thr?Val

290 295 300

Gly?Ala?Gly?Asp?Leu?Ala?Trp?Ser?Ile?Ser?Ala?Thr?Thr?Lys?His?Pro

305 310 315 320

Lys?Glu?Ala?Asn?Ala?Phe?Val?Glu?Tyr?Met?Thr?Arg?Pro?Glu?Val?Met

325 330 335

Gln?Lys?Tyr?Tyr?Asp?Val?Asp?Gly?Ser?Pro?Thr?Ala?Ile?Glu?Gly?Val

340 345 350

Lys?Gln?Ala?Gly?Glu?Asp?Ser?Pro?Leu?Ala?Gly?Met?Thr?Glu?Tyr?Ala

355 360 365

Phe?Thr?Asp?Arg?His?Leu?Val?Trp?Leu?Gln?Gln?Tyr?Trp?Thr?Ser?Glu

370 375 380

Ala?Asp?Phe?His?Thr?Leu?Thr?Met?Asn?Tyr?Val?Leu?Thr?Gly?Asp?Lys

385 390 395 400

Gln?Gly?Met?Val?Asn?Asp?Leu?Asn?Ala?Phe?Phe?Asn?Pro?Met?Lys?Ala

405 410 415

Asp?Val?Asp

<210>158

<211>559

<212>PRT

＜213〉streptococcus pneumoniae

<400>158

Met?Lys?Lys?Ile?Lys?Pro?His?Gly?Pro?Leu?Pro?Ser?Gln?Thr?Gln?Leu

1 5 10 15

Ala?Tyr?Leu?Gly?Asp?Glu?Leu?Ala?Ala?Phe?Ile?His?Phe?Gly?Pro?Asn

20 25 30

Thr?Phe?Tyr?Asp?Gln?Glu?Trp?Gly?Thr?Gly?Gln?Glu?Asp?Pro?Glu?Arg

35 40 45

Phe?Asn?Pro?Ser?Gln?Leu?Asp?Ala?Arg?Glu?Trp?Val?Arg?Val?Leu?Lys

50 55 60

Glu?Thr?Gly?Phe?Lys?Lys?Leu?Ile?Leu?Val?Val?Lys?His?His?Asp?Gly

65 70 75 80

Phe?Val?Leu?Tyr?Pro?Thr?Ala?His?Thr?Asp?Tyr?Ser?Val?Lys?Val?Ser

85 90 95

Pro?Trp?Arg?Arg?Gly?Lys?Gly?Asp?Leu?Leu?Leu?Glu?Val?Ser?Gln?Ala

100 105 110

Ala?Thr?Glu?Phe?Asp?Met?Asp?Met?Gly?Val?Tyr?Leu?Ser?Pro?Trp?Asp

115 120 125

Ala?His?Ser?Pro?Leu?Tyr?His?Val?Asp?Arg?Glu?Ala?Asp?Tyr?Asn?Ala

130 135 140

Tyr?Tyr?Leu?Ala?Gln?Leu?Lys?Glu?Ile?Leu?Ser?Asn?Pro?Asn?Tyr?Gly

145 150 155 160

Asn?Ala?Gly?Lys?Phe?Ala?Glu?Val?Trp?Met?Asp?Gly?Ala?Arg?Gly?Glu

165 170 175

Gly?Ala?Gln?Lys?Val?Asn?Tyr?Glu?Phe?Glu?Lys?Trp?Phe?Glu?Thr?Ile

180 185 190

Arg?Asp?Leu?Gln?Gly?Asp?Cys?Leu?Ile?Phe?Ser?Thr?Glu?Gly?Thr?Ser

195 200 205

Ile?Arg?Trp?Ile?Gly?Asn?Glu?Arg?Gly?Tyr?Ala?Gly?Asp?Pro?Leu?Trp

210 215 220

Gln?Lys?Val?Asn?Pro?Asp?Lys?Leu?Gly?Thr?Glu?Ala?Glu?Leu?Asn?Tyr

225 230 235 240

Leu?Gln?His?Gly?Asp?Pro?Ser?Gly?Thr?Ile?Phe?Ser?Ile?Gly?Glu?Ala

245 250 255

Asp?Val?Ser?Ile?Arg?Pro?Gly?Trp?Phe?Tyr?His?Glu?Asp?Gln?Asp?Pro

260 265 270

Lys?Ser?Leu?Glu?Glu?Leu?Val?Glu?Ile?Tyr?Phe?His?Ser?Val?Gly?Arg

275 280 285

Gly?Thr?Pro?Leu?Leu?Leu?Asn?Ile?Pro?Pro?Asn?Gln?Ala?Gly?Leu?Phe

290 295 300

Asp?Ala?Lys?Asp?Ile?Glu?Arg?Leu?Tyr?Glu?Phe?Ala?Thr?Tyr?Arg?Asn

305 310 315 320

Glu?Leu?Tyr?Lys?Glu?Asp?Leu?Ala?Leu?Gly?Ala?Glu?Val?Ser?Gly?Pro

325 330 335

Ala?Leu?Ser?Ala?Asp?Phe?Ala?Cys?Arg?His?Leu?Thr?Asp?Gly?Leu?Glu

340 345 350

Thr?Ser?Ser?Trp?Ala?Ser?Asp?Ala?Asp?Leu?Pro?Ile?Gln?Leu?Glu?Leu

355 360 365

Asp?Leu?Gly?Ser?Pro?Lys?Thr?Phe?Asp?Val?Ile?Glu?Leu?Arg?Glu?Asp

370 375 380

Leu?Lys?Leu?Gly?Gln?Arg?Ile?Ala?Ala?Phe?His?Val?Gln?Val?Glu?Val

385 390 395 400

Asp?Gly?Val?Trp?Gln?Glu?Phe?Gly?Ser?Gly?His?Thr?Val?Gly?Tyr?Lys

405 410 415

Arg?Leu?Leu?Arg?Gly?Ala?Val?Val?Glu?Ala?Gln?Lys?Ile?Arg?Val?Val

420 425 430

Ile?Thr?Glu?Ser?Gln?Ala?Leu?Pro?Leu?Leu?Thr?Lys?Ile?Ser?Leu?Tyr

435 440 445

Lys?Thr?Pro?Gly?Leu?Ser?Lys?Lys?Glu?Val?Val?Gln?Glu?Leu?Ala?Phe

450 455 460

Ala?Glu?Lys?Ser?Leu?Ala?Val?Ala?Lys?Gly?Glu?Asn?Ala?Tyr?Phe?Thr

465 470 475 480

Val?Lys?Arg?Arg?Glu?Cys?Ser?Gly?Pro?Leu?Glu?Ala?Lys?Ile?Ser?Ile

485 490 495

Gln?Pro?Gly?Thr?Gly?Val?His?Gly?Val?Ala?Tyr?Gln?Asp?Glu?Ile?Gln

500 505 510

Val?Leu?Ala?Phe?Gln?Thr?Gly?Glu?Thr?Glu?Lys?Ser?Leu?Thr?Leu?Pro

515 520 525

Thr?Leu?Tyr?Phe?Ala?Gly?Asp?Lys?Thr?Leu?Asp?Phe?Tyr?Leu?Asn?Leu

530 535 540

Thr?Val?Asp?Gly?Gln?Leu?Val?Asp?Gln?Leu?Gln?Val?Gln?Val?Ser

545 550 555

<210>159

<211>227

<212>PRT

＜213〉streptococcus pneumoniae

<400>159

Met?Leu?Glu?Arg?Leu?Lys?Arg?Ile?His?Tyr?Met?Phe?Trp?Ile?Ser?Leu

1 5 10 15

Ile?Phe?Met?Ile?Phe?Pro?Ile?Leu?Ser?Val?Val?Thr?Gly?Trp?Leu?Ser

20 25 30

Ala?Trp?His?Leu?Leu?Ile?Asp?Ile?Leu?Phe?Val?Val?Ala?Tyr?Leu?Gly

35 40 45

Val?Leu?Thr?Thr?Lys?Ser?Gln?Arg?Leu?Ser?Trp?Leu?Tyr?Trp?Gly?Leu

50 55 60

Met?Leu?Thr?Tyr?Val?Val?Gly?Asn?Thr?Ala?Phe?Val?Ala?Val?Asn?Tyr

65 70 75 80

Ile?Trp?Phe?Phe?Phe?Phe?Leu?Ser?Asn?Leu?Leu?Ser?Tyr?His?Phe?Ser

85 90 95

Val?Arg?Ser?Leu?Lys?Ser?Leu?His?Val?Trp?Thr?Phe?Leu?Leu?Ala?Gln

100 105 110

Val?Leu?Val?Val?Gly?Gln?Leu?Leu?Ile?Phe?Gln?Arg?Ile?Glu?Val?Glu

115 120 125

Phe?Leu?Phe?Tyr?Leu?Leu?Val?Ile?Leu?Thr?Phe?Val?Asp?Leu?Met?Thr

130 135 140

Phe?Gly?Leu?Val?Arg?Ile?Arg?Ile?Val?Glu?Asp?Leu?Lys?Glu?Ala?Gln

145 150 155 160

Val?Lys?Gln?Asn?Ala?Gln?Ile?Asn?Leu?Leu?Leu?Ala?Glu?Asn?Glu?Arg

165 170 175

Ser?Arg?Ile?Gly?Gln?Asp?Leu?His?Asp?Ser?Leu?Gly?His?Thr?Phe?Ala

180 185 190

Met?Leu?Ser?Val?Lys?Thr?Asp?Leu?Ala?Leu?Gln?Leu?Phe?Gln?Met?Glu

195 200 205

Ala?Tyr?Pro?Gln?Val?Glu?Lys?Glu?Leu?Lys?Glu?Ile?His?Gln?Ile?Ser

210 215 220

Lys?Asp?Pro

225

<210>160

<211>370

<212>PRT

＜213〉streptococcus pneumoniae

<400>160

Met?Asn?Asp?Lys?Leu?LysIle?Phe?Leu?Leu?Leu?Gly?Val?Phe?Phe?Leu

1 5 10 15

Ala?Ile?Thr?Gly?Phe?Tyr?Val?Leu?Leu?Ile?Arg?Asn?Ala?Gly?Gln?Thr

20 25 30

Asp?Ala?Ser?Gln?Ile?Glu?Lys?Ala?Ala?Val?Ser?Gln?Gly?Gly?Lys?Ala

35 40 45

Val?Lys?Lys?Thr?Glu?Ile?Ser?Lys?Asp?Ala?Asp?Leu?His?Glu?Ile?Tyr

50 55 60

Leu?Ala?Gly?Gly?Cys?Phe?Trp?Gly?Val?Glu?Glu?Tyr?Phe?Ser?Arg?Val

65 70 75 80

Pro?Gly?Val?Thr?Asp?Ala?Val?Ser?Gly?Tyr?Ala?Asn?Gly?Arg?Gly?Glu

85 90 95

Thr?Thr?Lys?Tyr?Glu?Leu?Ile?Asn?Gln?Thr?Gly?His?Ala?Glu?Thr?Val

100 105 110

His?Val?Thr?Tyr?Asp?Ala?Lys?Gln?Ile?Ser?Leu?Lys?Glu?Ile?Leu?Leu

115 120 125

His?Tyr?Phe?Arg?Ile?Ile?Asn?Pro?Thr?Ser?Lys?Asn?Lys?Gln?Gly?Asn

130 135 140

Asp?Val?Gly?Thr?Gln?Tyr?Arg?Thr?Gly?Val?Tyr?Tyr?Thr?Asp?Asp?Lys

145 150 155 160

Asp?Leu?Glu?Val?Ile?Asn?Gln?Val?Phe?Asp?Glu?Val?Ala?Lys?Lys?Tyr

165 170 175

Asp?Gln?Pro?Leu?Ala?Val?Glu?Lys?Glu?Asn?Leu?Lys?Asn?Phe?Val?Val

180 185 190

Ala?Glu?Asp?Tyr?His?Gln?Asp?Tyr?Leu?Lys?Lys?Asn?Pro?Asn?Gly?Tyr

195 200 205

Cys?His?Ile?Asn?Val?Asn?Gln?Ala?Ala?Tyr?Pro?Val?Ile?Asp?Ala?Ser

210 215 220

Lys?Tyr?Pro?Lys?Pro?Ser?Asp?Glu?Glu?Leu?Lys?Lys?Thr?Leu?Ser?Pro

225 230 235 240

Glu?Glu?Tyr?Ala?Val?Thr?Gln?Glu?Asn?Gln?Thr?Glu?Arg?Ala?Phe?Ser

245 250 255

Asn?Arg?Tyr?Trp?Asp?Lys?Phe?Glu?Ser?Gly?Ile?Tyr?Val?Asp?Ile?Ala

260 265 270

Thr?Gly?Glu?Pro?Leu?Phe?Ser?Ser?Lys?Asp?Lys?Phe?Glu?Ser?Gly?Cys

275 280 285

Gly?Trp?Pro?Ser?Phe?Thr?Gln?Pro?Ile?Ser?Pro?Asp?Val?Val?Thr?Tyr

290 295 300

Lys?Glu?Asp?Lys?Ser?Tyr?Asn?Met?Thr?Arg?Met?Glu?Val?Arg?Ser?Arg

305 310 315 320

ValGly?Asp?Ser?His?Leu?Gly?His?Val?Phe?Thr?Asp?Gly?Pro?Gln?Asp

325 330 335

Lys?Gly?Gly?Leu?Arg?Tyr?Cys?Ile?Asn?Ser?Leu?Ser?Ile?Arg?Phe?Ile

340 345 350

Pro?Lys?Asp?Gln?Met?Glu?Glu?Lys?Gly?Tyr?Ala?Tyr?Leu?Leu?Asp?Tyr

355 360 365

Val?Asp

370

<210>161

<211>338

<212>PRT

＜213〉streptococcus pneumoniae

<400>161

Met?Lys?Lys?Lys?Trp?Met?Tyr?Tyr?Ala?Ala?Cys?Ser?Ser?Asn?Glu?Ser

1 5 10 15

Ala?Asp?Asp?Ser?Ser?Ser?Asp?Lys?Gly?Asp?Gly?Gly?Ser?Leu?Val?Val

20 25 30

Tyr?Ser?Pro?Asn?Ser?Glu?Gly?Leu?Ile?Gly?Ala?Thr?Ile?Pro?Ala?Phe

35 40 45

Glu?Glu?Lys?Tyr?Gly?Ile?Lys?Val?Glu?Leu?Ile?Gln?Ala?Gly?Thr?Gly

50 55 60

Glu?Leu?Phe?Lys?Lys?Leu?Glu?Ser?Glu?Lys?Glu?Val?Pro?Val?Ala?Asp

65 70 75 80

Val?Ile?Phe?Gly?Gly?Ser?Tyr?Thr?Gln?Tyr?Thr?Thr?His?Gly?Glu?Leu

85 90 95

Phe?Glu?Asn?Tyr?Thr?Ser?Lys?Glu?Asn?Asp?Asn?Val?Ile?Lys?Glu?Tyr

100 105 110

Gln?Asn?Thr?Thr?Gly?Tyr?Ser?Thr?Pro?Tyr?Thr?Leu?Asp?Gly?Ser?Val

115 120 125

Leu?Ile?Val?Asn?Pro?Asp?Leu?Thr?Lys?Gly?Met?Asn?Ile?Glu?Gly?Tyr

130 135 140

Asn?Asp?Leu?Phe?Lys?Pro?Glu?Leu?Lys?Gly?Lys?Ile?Ala?Thr?Ala?Asp

145 150 155 160

Pro?Ala?Asn?Ser?Ser?Ser?Ala?Phe?Ala?Gln?Leu?Thr?Asn?Met?Leu?Gln

165 170 175

Ala?Gln?Gly?Gly?Tyr?Lys?Asp?Asp?Lys?Ala?Trp?Ser?Tyr?Val?Lys?Asp

180 185 190

Leu?Phe?Thr?Leu?Ile?Asp?Gly?Lys?Ile?Gly?Ser?Ser?Ser?Ser?Ser?Val

195 200 205

Tyr?Lys?Val?Val?Ala?Asp?Gly?Glu?Met?Ala?Val?Gly?Leu?Ser?Tyr?Glu

210 215 220

Asp?Pro?Ala?Val?Lys?Leu?Leu?Asn?Asp?Gly?Ala?Asn?Ile?Lys?Val?Val

225 230 235 240

Tyr?Pro?Lys?Glu?Gly?Thr?Val?Phe?Leu?Pro?Ala?Ser?Ala?Ala?Ile?Val

245 250 255

Lys?Lys?Ser?Lys?Asn?Met?Glu?Asn?Ala?Lys?Lys?Phe?Ile?Asp?Phe?Ile

260 265 270

Ile?Ser?Gln?Glu?Val?Gln?Asp?Thr?Leu?Gly?Thr?Thr?Thr?Thr?Asn?Arg

275 280 285

Pro?Val?Arg?Lys?Asn?Ala?Lys?Thr?Ser?Glu?Asn?Met?Lys?Pro?Ile?Asp

290 295 300

Lys?Ile?Lys?Thr?Leu?Thr?Glu?Asp?Tyr?Asp?Tyr?Val?Ile?Lys?Asn?Lys

305 310 315 320

Ser?Asp?Ile?Val?Lys?Lys?Tyr?Asn?Glu?Val?Phe?Thr?Asp?Ile?Gln?Ser

325 330 335

Lys?Gln

<210>162

<211>363

<212>PRT

＜213〉streptococcus pneumoniae

<400>162

Met?Ser?Glu?Ile?Lys?Ile?Ile?Asn?Ala?Lys?Lys?Ile?Tyr?His?Asp?Val

1 5 10 15

Pro?Val?Ile?Glu?Asn?Leu?Asn?Ile?Thr?Ile?Pro?Lys?Gly?Ser?Leu?Phe

20 25 30

Thr?Leu?Leu?Gly?Ala?Ser?Gly?Cys?Gly?Lys?Thr?Thr?Leu?Leu?Arg?Met

35 40 45

Ile?Ala?Gly?Phe?Asn?Ser?Ile?Glu?Gly?Gly?Glu?Phe?Tyr?Phe?Asp?Asp

50 55 60

Thr?Lys?Ile?Asn?Asn?Met?Glu?Pro?Ser?Lys?Arg?Asn?Ile?Gly?Met?Val

65 70 75 80

Phe?Gln?Asn?Tyr?Ala?Ile?Phe?Pro?His?Leu?Thr?Val?Arg?Asp?Asn?Val

85 90 95

Ala?Phe?Gly?Leu?Met?Gln?Lys?Lys?Val?Pro?Lys?Glu?Glu?Leu?Ile?Gln

100 105 110

Gln?Thr?Asn?Lys?Tyr?Leu?Glu?Leu?Met?Gln?Ile?Ala?Gln?Tyr?Ala?Asp

115 120 125

Arg?Lys?Pro?Asp?Lys?Leu?Ser?Gly?Gly?Gln?Gln?Gln?Arg?Val?Thr?Leu

130 135 140

Ala?Cys?Ala?Leu?Ala?Val?Asn?Pro?Ser?Val?Leu?Leu?Met?Asp?Glu?Pro

145 150 155 160

Leu?Ser?Asn?Leu?Glu?Ala?Lys?Leu?Arg?Leu?Asp?Met?Arg?Gln?Ala?Ile

165 170 175

Arg?Glu?Ile?Gln?His?Glu?Val?Gly?Ile?Thr?Thr?Val?Tyr?Val?Thr?His

180 185 190

Asp?Gln?Glu?Glu?Ala?Met?Ala?Ile?Ser?Asp?Gln?Ile?Ala?Val?Met?Lys

195 200 205

Asp?Gly?Val?Ile?Gln?Gln?Ile?Gly?Arg?Pro?Lys?Glu?Leu?Tyr?His?Lys

210 215 220

Pro?Ala?Asn?Glu?Phe?Val?Ala?Thr?Phe?Ile?Gly?Arg?Thr?Asn?Ile?Ile

225 230 235 240

Pro?Ala?Asn?Leu?Glu?Lys?Arg?Ser?Asp?Gly?Ala?Tyr?Ile?Val?Phe?Ser

245 250 255

Asp?Gly?Tyr?Ala?Leu?Arg?Met?Pro?Ala?Leu?Asp?Gln?Val?Glu?Glu?Gln

260 265 270

Ala?Ile?His?Val?Ser?Ile?Arg?Pro?Glu?Glu?Phe?Ile?Lys?Asp?Glu?Ser

275 280 285

Gly?Asp?Ile?Glu?Gly?Thr?Ile?Arg?Asp?Ser?Val?Tyr?Leu?Gly?Leu?Asn

290 295 300

Thr?Asp?Tyr?Phe?Ile?Glu?Thr?Gly?Phe?Ala?Ser?Lys?Ile?Gln?Val?Ser

305 310 315 320

Glu?Glu?Ser?Thr?Phe?Glu?Glu?Asp?Leu?Gln?Lys?Gly?Asn?Arg?Ile?Arg

325 330 335

Leu?Arg?Ile?Asn?Thr?Gln?Lys?Leu?Asn?Ile?Phe?Ser?Ala?Asp?Gly?Ser

340 345 350

Gln?Asn?Leu?Ile?Lys?Gly?Val?Asn?His?Gly?Thr

355 360

<210>163

<211>313

<212>PRT

＜213〉streptococcus pneumoniae

<400>163

Met?Lys?Lys?Lys?Leu?Leu?Ala?Gly?Ala?Ile?Thr?Leu?Leu?Ser?Val?Ala

1 5 10 15

Thr?Leu?Ala?Ala?Cys?Ser?Lys?Gly?Ser?Glu?Gly?Ala?Asp?Leu?IIe?Ser

20 25 30

Met?Lys?Gly?Asp?Val?Ile?Thr?Glu?His?Gln?Phe?Tyr?Glu?Gln?Val?Lys

35 40 45

Ser?Asn?Pro?Ser?Ala?Gln?Gln?Val?Leu?Leu?Asn?Met?Thr?Ile?Gln?Lys

50 55 60

Val?Phe?Glu?Lys?Gln?Tyr?Gly?Ser?Glu?Leu?Asp?Asp?Lys?Glu?Val?Asp

65 70 75 80

Asp?Thr?Ile?Ala?Glu?Glu?Lys?Lys?Gln?Tyr?Gly?Glu?Asn?Tyr?Gln?Arg

85 90 95

Val?Leu?Ser?Gln?Ala?Gly?Met?Thr?Leu?Glu?Thr?Arg?Lys?Ala?Gln?Ile

100 105 110

Arg?Thr?Ser?Lys?Leu?Val?Glu?Leu?Ala?Val?Lys?Lys?Val?Ala?Glu?Ala

115 120 125

Glu?Leu?Thr?Asp?Glu?Ala?Tyr?Lys?Lys?Ala?Phe?Asp?Glu?Tyr?Thr?Pro

130 135 140

Asp?Val?Thr?Ala?Gln?Ile?Ile?Arg?Leu?Asn?Asn?Glu?Asp?Lys?Ala?Lys

145 150 155 160

Glu?Val?Leu?Glu?Lys?Ala?Lys?Ala?Glu?Gly?Ala?Asp?Phe?Ala?Gln?Leu

165 170 175

Ala?Lys?Asp?Asn?Ser?Thr?Asp?Glu?Lys?Thr?Lys?Glu?Asn?Gly?Gly?Glu

180 185 190

Ile?Thr?Phe?Asp?Ser?Ala?Ser?Thr?Glu?Val?Pro?Glu?Gln?Val?Lys?Lys

195 200 205

Ala?Ala?Phe?Ala?Leu?Asp?Val?Asp?Gly?Val?Ser?Asp?Val?Ile?Thr?Ala

210 215 220

Thr?Gly?Thr?Gln?Ala?Tyr?Ser?Ser?Gln?Tyr?Tyr?Ile?Val?Lys?Leu?Thr

225 230 235 240

Lys?Lys?Thr?Glu?Lys?Ser?Ser?Asn?Ile?Asp?Asp?Tyr?Lys?Glu?Lys?Leu

245 250 255

Lys?Thr?Val?Ile?Leu?Thr?Gln?Lys?Gln?Asn?Asp?Ser?Thr?Phe?Val?Gln

260 265 270

Ser?Ile?Ile?Gly?Lys?Glu?Leu?Gln?Ala?Ala?Asn?Ile?Lys?Val?Lys?Asp

275 280 285

Gln?Ala?Phe?Gln?Asn?Ile?Phe?Thr?Gln?Tyr?Ile?Gly?Gly?Gly?Asp?Ser

290 295 300

Ser?Ser?Ser?Ser?Ser?Thr?Ser?Asn?Glu

305 310

<210>164

<211>465

<212>PRT

＜213〉streptococcus pneumoniae

<400>164

Met?Lys?Lys?Asn?Ile?Lys?Gln?Tyr?Val?Thr?Leu?Gly?Thr?Val?Val?Val

1 5 10 15

Leu?Ser?Ala?Phe?Val?Ala?Asn?Ser?Val?Ala?Ala?Gln?Glu?Thr?Glu?Thr

20 25 30

Ser?Glu?Val?Ser?Thr?Pro?Lys?Leu?Val?Gln?Pro?Val?Ala?Pro?Thr?Thr

35 40 45

Pro?Ile?Ser?Glu?Val?Gln?Pro?Thr?Ser?Asp?Asn?Ser?Ser?Glu?Val?Thr

50 55 60

Val?Gln?Pro?Arg?Thr?Val?Glu?Thr?Thr?Val?Lys?Asp?Pro?Ser?Ser?Thr

65 70 75 80

Ala?Glu?Glu?Thr?Pro?Val?Leu?Glu?Lys?Asn?Asn?Val?Thr?Leu?Thr?Gly

85 90 95

Gly?Gly?Glu?Asn?Val?Thr?Lys?Glu?Leu?Lys?Asp?Lys?Phe?Thr?Ser?Gly

100 105 110

Asp?Phe?Thr?Val?Val?Ile?Lys?Tyr?Asn?Gln?Ser?Ser?Glu?Lys?Gly?Leu

115 120 125

Gln?Ala?Leu?Phe?Gly?Ile?Ser?Asn?Ser?Lys?Pro?Gly?Gln?Gln?Asn?Ser

130 135 140

Tyr?Val?Asp?Val?Phe?Leu?Arg?Asp?Asn?Gly?Glu?Leu?Gly?Met?Glu?Ala

145 150 155 160

Arg?Asp?Thr?Ser?Ser?Asn?Lys?Asn?Asn?Leu?Val?Ser?Arg?Pro?Ala?Ser

165 170 175

Val?Trp?Gly?Lys?Tyr?Lys?Gln?Glu?Ala?Val?Thr?Asn?Thr?Val?Ala?Val

180 185 190

Val?Ala?Asp?Ser?Val?Lys?Lys?Thr?Tyr?Ser?Leu?Tyr?Ala?Asn?Gly?Thr

195 200 205

Lys?Val?Val?Glu?Lys?Lys?Val?Asp?Asn?Phe?Leu?Asn?Ile?Lys?Asp?Ile

210 215 220

Lys?Gly?Ile?Asp?Tyr?Tyr?Met?Leu?Gly?Gly?Val?Lys?Arg?Ala?Gly?Lys

225 230 235 240

Thr?Ala?Phe?Gly?Phe?Asn?Gly?Thr?Leu?Glu?Asn?Ile?Lys?Phe?Phe?Asn

245 250 255

Ser?Ala?Leu?Asp?Glu?Glu?Thr?Val?Lys?Lys?Met?Thr?Thr?Asn?Ala?Val

260 265 270

Thr?Gly?His?Leu?Ile?Tyr?Thr?Ala?Asn?Asp?Thr?Thr?Gly?Ser?Asn?Tyr

275 280 285

Phe?Arg?Ile?Pro?Val?Leu?Tyr?Thr?Phe?Ser?Asn?Gly?Arg?Val?Phe?Ser

290 295 300

Ser?Ile?Asp?Ala?Arg?Tyr?Gly?Gly?Thr?His?Asp?Phe?Leu?Asn?Lys?Ile

305 310 315 320

Asn?Ile?Ala?Thr?Ser?Tyr?Ser?Asp?Asp?Asn?Gly?Lys?Thr?Trp?Thr?Lys

325 330 335

Pro?Lys?Leu?Thr?Leu?Ala?Phe?Asp?Asp?Phe?Ala?Pro?Val?Pro?Leu?Glu

340 345 350

Trp?Pro?Arg?Glu?Val?Gly?Gly?Arg?Asp?Leu?Gln?Ile?Ser?Gly?Gly?Ala

355 360 365

Thr?Tyr?Ile?Asp?Ser?Val?Ile?Val?Glu?Lys?Lys?Asn?Lys?Gln?Val?Leu

370 375 380

Met?Phe?Ala?Asp?Val?Met?Pro?Ala?Gly?Val?Ser?Phe?Arg?Glu?Ala?Thr

385 390 395 400

Arg?Lys?Asp?Ser?Gly?Tyr?Lys?Gln?Ile?Asp?Gly?Asn?Tyr?Tyr?Leu?Lys

405 410 415

Leu?Arg?Lys?Gln?Gly?Asp?Thr?Asp?Tyr?Asn?Tyr?Thr?Ile?Arg?Glu?Asn

420 425 430

Gly?Thr?Val?Tyr?Asp?Asp?Arg?Thr?Asn?Arg?Pro?Thr?Glu?Phe?Ser?Val

435 440 445

Asp?Lys?Asn?Phe?Gly?Ile?Lys?Gln?Asn?Gly?Asn?Tyr?Leu?Thr?Val?Glu

450 455 460

Arg

465

<210>165

<211>266

<212>PRT

＜213〉streptococcus pneumoniae

<400>165

Met?Lys?Lys?Phe?Ser?Leu?Leu?Leu?Ala?Ile?Leu?Pro?Phe?Leu?Val?Ala

1 5 10 15

Cys?Glu?Asn?Gln?Ala?Thr?Pro?Lys?Glu?Thr?Ser?Ala?Gln?Lys?Thr?Ile

20 25 30

Val?Leu?Ala?Thr?Ala?Gly?Asp?Val?Pro?Pro?Phe?Asp?Tyr?Glu?Asp?Lys

35 40 45

Gly?Asn?Leu?Thr?Gly?Phe?Asp?Ile?Glu?Val?Leu?Lys?Ala?Val?Asp?Glu

50 55 60

Lys?Leu?Ser?Asp?Tyr?Glu?Ile?Gln?Phe?Gln?Arg?Thr?Ala?Trp?Glu?Ser

65 70 75 80

Ile?Phe?Pro?Gly?Leu?Asp?Ser?Gly?His?Tyr?Gln?Ala?Ala?Ala?Asn?Asn

85 90 95

Leu?Ser?Tyr?Thr?Lys?Glu?Arg?Ala?Glu?Lys?Tyr?Leu?Tyr?Ser?Leu?Pro

100 105 110

Ile?Ser?Asn?Asn?Pro?Leu?Val?Leu?Val?Ser?Asn?Lys?Lys?Asn?Pro?Leu

115 120 125

Thr?Ser?Leu?Asp?Gln?Ile?Ala?Gly?Lys?Thr?Thr?Gln?Glu?Asp?Thr?Gly

130 135 140

Thr?Ser?Asn?Ala?Gln?Phe?Ile?Asn?Asn?Trp?Asn?Gln?Lys?His?Thr?Asp

145 150 155 160

Asn?Pro?Ala?Thr?Ile?Asn?Phe?Ser?Gly?Glu?Asp?Ile?Gly?Lys?Arg?Ile

165 170 175

Leu?Asp?Leu?Ala?Asn?Gly?Glu?Phe?Asp?Phe?Leu?Val?Phe?Asp?Lys?Val

180 185 190

Ser?Val?Gln?Lys?Ile?Ile?Lys?Asp?Arg?Gly?Leu?Asp?Leu?Ser?Val?Val

195 200 205

Asp?Leu?Pro?Ser?Ala?Asp?Ser?Pro?Ser?Asn?Tyr?Ile?Ile?Phe?Ser?Ser

210 215 220

Asp?Gln?Lys?Glu?Phe?Lys?Glu?Gln?Phe?Asp?Lys?Ala?Leu?Lys?Glu?Leu

225 230 235 240

Tyr?Gln?Asp?Gly?Thr?Leu?Glu?Lys?Leu?Ser?Asn?Thr?Tyr?Leu?Gly?Gly

245 250 255

Ser?Tyr?Leu?Pro?Asp?Gln?Ser?Gln?Leu?Gln

260 265

<210>166

<21l>259

<212>PRT

＜213〉streptococcus pneumoniae

<400>166

Met?Lys?Lys?Asn?Ser?Leu?Tyr?Ile?Ile?Ser?Ser?Leu?Phe?Phe?Ala?Cys

1 5 10 15

Val?Leu?Phe?Val?Tyr?Ala?Thr?Ala?Thr?Asn?Phe?Gln?Asn?Ser?Thr?Ser

20 25 30

Ala?Arg?Gln?Val?Lys?Thr?Glu?Thr?Tyr?Thr?Asn?Thr?Val?Thr?Asn?Val

35 40 45

Pro?Ile?Asp?Ile?Arg?Tyr?Asn?Ser?Asp?Lys?Tyr?Phe?Ile?Ser?Gly?Phe

50 55 60

Ala?Ser?Glu?Val?Ser?Val?Val?Leu?Thr?Gly?Ala?Asn?Arg?Leu?Ser?Leu

65 70 75 80

Ala?Ser?Glu?Met?Gln?Glu?Ser?Thr?Arg?Lys?Phe?Lys?Val?Thr?Ala?Asp

85 90 95

Leu?Thr?Asp?Ala?Gly?Val?Gly?Thr?Ile?Glu?Val?Pro?Leu?Ser?Ile?Glu

100 105 110

Asp?Leu?Pro?Asn?Gly?Leu?Thr?Ala?Val?Ala?Thr?Pro?Gln?Lys?Ile?Thr

115 120 125

Val?Lys?Ile?Gly?Lys?Lys?Ala?Gln?Lys?Asp?Lys?Val?Lys?Ile?Val?Pro

130 135 140

Glu?Ile?Asp?Pro?Ser?GlnIle?Asp?Ser?Arg?Val?Gln?Ile?Glu?Asn?Val

145 150 155 160

Met?Val?Ser?Asp?Lys?Glu?Val?Ser?Ile?Thr?Ser?Asp?Gln?Glu?Thr?Leu

165 170 175

Asp?Arg?Ile?Asp?Lys?Ile?Ile?Ala?Val?Leu?Pro?Thr?Ser?Glu?Arg?Ile

180 185 190

Thr?Gly?Asn?Tyr?Ser?Gly?Ser?Val?Pro?Leu?Gln?Ala?Ile?Asp?Arg?Asn

195 200 205

Gly?Val?Val?Leu?Pro?Ala?Val?Ile?Thr?Pro?Phe?Asp?Thr?Ile?Met?Lys

210 215 220

Val?Thr?Thr?Lys?Pro?Val?Ala?Pro?Ser?Ser?Ser?Thr?Ser?Asn?Ser?Ser

225 230 235 240

Thr?Ser?Ser?Ser?Ser?Glu?Thr?Ser?Ser?Ser?Thr?Lys?Ala?Thr?Ser?Ser

245 250 255

Lys?Thr?Asn

<210>167

<211>263

<212>PRT

＜213〉streptococcus pneumoniae

<400>167

Met?Leu?Ile?Gly?Glu?Gly?Tyr?Arg?Thr?Phe?Pro?Val?Leu?Ile?Tyr?Thr

1 5 10 15

Gln?Phe?Ile?Ser?Glu?Val?Gly?Gly?Asn?Ser?Ala?Phe?Ala?Ile?Met?Ala

20 25 30

Ile?Ile?Ile?Ala?Leu?Ala?Ile?Phe?Leu?Ile?Gln?Lys?His?Ile?Ala?Asn

35 40 45

Arg?Tyr?Ser?Phe?Ser?Met?Asn?Leu?Leu?His?Pro?Ile?Glu?Pro?Lys?Lys

50 55 60

Thr?Thr?Lys?Gly?Lys?Met?Ala?Ala?Ile?Tyr?Ala?Thr?Val?Tyr?Gly?Ile

65 70 75 80

Ile?Phe?Ile?Ser?Val?Leu?Pro?Gln?Ile?Tyr?Leu?Ile?Tyr?Thr?Ser?Phe

85 90 95

Leu?Lys?Thr?Ser?Gly?Met?Val?Ser?Val?Lys?Gly?Tyr?Ser?Pro?Asn?Ser

100 105 110

Tyr?Lys?Val?Ala?Phe?His?Arg?Met?Gly?Ser?Ala?Ile?Phe?Asn?Thr?Ile

115 120 125

Arg?Ile?Pro?Leu?Ile?Ala?Leu?Val?Leu?Val?Val?Leu?Phe?Ala?Thr?Phe

130 135 140

Ile?Ser?Tyr?Leu?Ala?Val?Arg?Lys?Arg?Asn?Leu?Phe?Thr?Asn?Leu?Ile

145 150 155 160

Asp?Ser?Leu?Ser?Met?Val?Pro?Tyr?Ile?Val?Pro?Gly?Thr?Val?Leu?Gly

165 170 175

Ile?Ala?Phe?Ile?Ser?Ser?Phe?Asn?Thr?Gly?Leu?Phe?Gly?Ser?Gly?Phe

180 185 190

Leu?Met?Ile?Thr?Gly?Thr?Ala?Phe?Ile?Leu?Ile?Met?Ser?Leu?Ser?Ala

195 200 205

Arg?Arg?Leu?Pro?Tyr?Thr?Ile?Arg?Ser?Ser?Val?Ala?Ser?Leu?Gln?Gln

210 215 220

Ile?Ala?Pro?Ser?Ile?Glu?Glu?Ala?Ala?Glu?Ser?Leu?Gly?Ser?Ser?Arg

225 230 235 240

Leu?Asn?Thr?Phe?Ala?Lys?Ile?Thr?Thr?Pro?Met?Met?Leu?Ser?Gly?Ile

245 250 255

Ile?Ser?Gly?Ala?Ile?Leu?Ser

260

<210>168

<211>1332

<212>DNA

＜213〉streptococcus pneumoniae

<400>168

atgataaaaa?atcctaaatt?attaaccaag?tcttttttaa?gaagttttgc?aattctaggt?60

ggtgttggtc?tagtcattca?tatagctatt?tatttgacct?ttccttttta?ttatattcaa?120

ctggaggggg?aaaagtttaa?tgagagcgca?agagtgttta?cggagtattt?aaagactaag?180

acatctgatg?aaattccaag?cttactccag?tcttattcaa?agtccttgac?catatctgct?240

caccttaaaa?gagatattgt?agataagcgg?ctccctcttg?tgcatgactt?ggatattaaa?300

gatggaaagc?tatcaaatta?tatcgtgatg?ttagatatgt?ctgttagtac?agcagatggt?360

aaacaggtaa?ccgtgcaatt?tgttcacggg?gtggatgtct?acaaagaagc?aaagaatatt?420

ttgcttttgt?atctcccata?tacatttttg?gttacaattg?ctttttcctt?tgttttttct?480

tatttttata?ctaaacgctt?gctcaatcct?cttttttaca?tttcagaagt?gactagtaaa?540

atgcaagatt?tggatgacaa?tattcgtttt?gatgaaagta?ggaaagatga?agttggtgaa?600

gttggaaaac?agattaatgg?tatgtatgag?cacttgttga?aggttattta?tgagttggaa?660

agtcgtaatg?agcaaattgt?aaaattgcaa?aatcaaaagg?tttcctttgt?ccgcggagca?720

tcacatgagt?tgaaaacccc?tttagccagt?cttagaatta?tcctagagaa?tatgcagcat?780

aatattggag?attacaaaga?tcatccaaaa?tatattgcaa?agagtataaa?taagattgac?840

cagatgagcc?acttattaga?agaagtactg?gagtcttcta?aattccaaga?gtggacagag?900

tgtcgtgaga?ccttgactgt?taagccagtt?ttagtagata?ttttatcacg?ttatcaagaa?960

ttagctcatt?caataggtgt?tacaattgaa?aatcaattga?cagatgctac?cagggtcgtc?1020

atgagtctta?gggcattgga?taaggttttg?acaaacctga?ttagtaatgc?aattaaatat?1080

tcagataaaa?atgggcgtgt?aatcatatcc?gagcaagatg?gctatctctc?tatcaaaaat?1140

acatgtgcgc?ctctaagtga?ccaagaacta?gaacatttat?ttgatatatt?ctatcattct?1200

caaatcgtga?cagataagga?tgaaagttcc?ggtttgggtc?tttacattgt?gaataatatt?1260

ttagaaagct?atcaaatgga?ttatagtttt?ctcccttatg?aacacggtat?ggaatttaag?1320

attagcttgt?ag 1332

<210>169

<211>873

<212>DNA

＜213〉streptococcus pneumoniae

<400>169

atggataaaa?ttattaaaac?tatatcagaa?agcggagcct?ttcgtgcttt?tgtccttgat?60

agcactgaaa?ccgtccgcac?tgctcaagaa?aaacatcaaa?cccaagctag?ctcaactgta?120

gcgcttggtc?gaactcttat?cgctagccag?attctcgcag?ccaatgaaaa?aggaaatacc?180

aaacttacag?ttaaggtgtt?gggatctagc?tctctaggtg?ctattatcac?cgtcgctgat?240

accaagggga?acgtcaaagg?ctatgttcaa?aatcctggtg?ttgacatcaa?aaagactgcg?300

actggtgaag?tcctagtcgg?accttttgtt?ggaaatggtc?aattcctcgt?tatcacagac?360

tacggtactg?gaaatcctta?caactctata?actcccctca?tctctggaga?aatcggtgaa?420

gaccttgcct?tttaccttac?tgaaagccaa?caaacgcctt?cagcggtcgg?cctcaatgtc?480

cttttggacg?aggaagacaa?ggtcaaggtt?gcaggtggtt?tcctagttca?agtcttgcca?540

ggagccaaga?aagaagagat?tgctcgcttt?gaaaaacgca?tccaagaaat?gccagctatc?600

tctactcttc?tcgaaagcga?cgaccatatc?gaagccctcc?tcaaggctat?ctacggggac?660

gaagcctaca?agcgtctttc?tgaagaagaa?atccgtttcc?aatgtgactg?tagccatgaa?720

cgctttatga?acgctcttgc?cagccttcca?agctcagact?tacaggaaat?gaaagaggaa?780

gaccacgggg?cagaaatcac?ttgtcaattc?tgccaaacta?cttacaactt?tgatgaaaag?840

gacctggagg?aactcattcg?tgacaaatct?taa?873

<210>170

<211>459

<212>DNA

＜213〉streptococcus pneumoniae

<400>170

atgaaatcaa?taactaaaaa?gattaaagca?actcttgcag?gagtagctgc?cttgtttgca?60

gtatttgctc?catcatttgt?atctgctcaa?gaatcatcaa?cttacactgt?taaagaaggt?120

gatacacttt?cagaaatcgc?tgaaactcac?aacacaacag?ttgaaaaatt?ggcagaaaac?180

aaccacattg?ataacattca?tttgatttat?gttgatcaag?agttggttat?cgatggccct?240

gtagcgcctg?ttgcaacacc?agcgccagct?acttatgcgg?caccagccgc?tcaagatgaa?300

actgtttcag?ctccagtagc?agaaactcca?gtagtaagtg?aaacagttgt?ttcaactgta?360

agcggatctg?aagcagaagc?caaagaatgg?atcgctcaaa?aagaatcagg?tggtagtata?420

cagctacaaa?tggacgttat?atcggacgtt?accaattaa 459

<210>171

<211>2034

<212>DNA

＜213〉streptococcus pneumoniae

<400>171

atgaatttag?gagaattttg?gtacaataaa?ataaataaga?acagaggaag?aaggttaatg?60

aagaaagtaa?gatttatttt?tttagctctg?ctatttttct?tagctagtcc?agagggtgca?120

atggctagtg?atggtacttg?gcaaggaaaa?cagtatctga?aagaagatgg?cagtcaagca?180

gcaaatgagt?gggtttttga?tactcattat?caatcttggt?tctatataaa?agcagatgct?240

aactatgctg?aaaatgaatg?gctaaagcaa?ggtgacgact?atttttacct?caaatctggt?300

ggctatatgg?ccaaatcaga?atgggtagaa?gacaagggag?ccttttatta?tcttgaccaa?360

gatggaaaga?tgaaaagaaa?tgcttgggta?ggaacttcct?atgttggtgc?aacaggtgcc?420

aaagtaatag?aagactgggt?ctatgattct?caatacgatg?cttggtttta?tatcaaagca?480

gatggacagc?acgcagagaa?agaatggctc?caaattaaag?ggaaggacta?ttatttcaaa?540

tccggtggtt?atctactgac?aagtcagtgg?attaatcaag?cttatgtgaa?tgctagtggt?600

gccaaagtac?agcaaggttg?gctttttgac?aaacaatacc?aatcttggtt?ttacatcaaa?660

gaaaatggaa?actatgctga?taaagaatgg?attttcgaga?atggtcacta?ttattatcta?720

aaatccggtg?gctacatggc?agccaatgaa?tggatttggg?ataaggaatc?ttggttttat?780

ctcaaatttg?atgggaaaat?ggctgaaaaa?gaatgggtct?acgattctca?tagtcaagct?840

tggtactact?tcaaatccgg?tggttacatg?acagccaatg?aatggatttg?ggataaggaa?900

tcttggtttt?atctcaaatc?tgatgggaaa?atagctgaaa?aagaatgggt?ctacgattct?960

catagtcaag?cttggtacta?cttcaaatcc?ggtggttaca?tgacagccaa?tgaatggatt?1020

tgggataagg?aatcttggtt?ttacctcaaa?tctgatggga?aaatagctga?aaaagaatgg?1080

gtctacgatt?ctcatagtca?agcttggtac?tacttcaaat?ctggtggcta?catggcgaaa?1140

aatgagacag?tagatggtta?tcagcttgga?agcgatggta?aatggcttgg?aggaaaaact?1200

acaaatgaaa?atgctgctta?ctatcaagta?gtgcctgtta?cagccaatgt?ttatgattca?1260

gatggtgaaa?agctttccta?tatatcgcaa?ggtagtgtcg?tatggctaga?taaggataga?1320

aaaagtgatg?acaagcgctt?ggctattact?atttctggtt?tgtcaggcta?tatgaaaaca?1380

gaagatttac?aagcgctaga?tgctagtaag?gactttatcc?cttattatga?gagtgatggc?1440

caccgttttt?atcactatgt?ggctcagaat?gctagtatcc?cagtagcttc?tcatctttct?1500

gatatggaag?taggcaagaa?atattattcg?gcagatggcc?tgcattttga?tggttttaag?1560

cttgagaatc?ccttcctttt?caaagattta?acagaggcta?caaactacag?tgctgaagaa?1620

ttggataagg?tatttagttt?gctaaacatt?aacaatagcc?ttttggagaa?caagggcgct?1680

acttttaagg?aagccgaaga?acattaccat?atcaatgctc?tttatctcct?tgcccatagt?1740

gccctagaaa?gtaactgggg?aagaagtaaa?attgccaaag?ataagaataa?tttctttggc?1800

attacagcct?atgatacgac?cccttacctt?tctgctaaga?catttgatga?tgtggataag?1860

ggaattttag?gtgcaaccaa?gtggattaag?gaaaattata?tcgatagggg?aagaactttc?1920

cttggaaaca?aggcttctgg?tatgaatgtg?gaatatgctt?cagaccctta?ttggggcgaa?1980

aaaattgcta?gtgtgatgat?gaaaatcaat?gagaagctag?gtggcaaaga?ttag 2034

<210>172

<211>930

<212>DNA

＜213〉streptococcus pneumoniae

<400>172

atgaaaaaat?taggtacatt?actcgttctc?tttctttctg?caatcattct?tgtagcatgt?60

gctagcggaa?aaaaagatac?aacttctggt?caaaaactaa?aagttgttgc?tacaaactca?120

atcatcgctg?atattactaa?aaatattgct?ggtgacaaaa?ttgaccttca?tagtatcgtt?180

ccgattgggc?aagacccaca?cgaatacgaa?ccacttcctg?aagacgttaa?gaaaacttct?240

gaggctaatt?tgattttcta?taacggtatc?aaccttgaaa?caggtggcaa?tgcttggttt?300

acaaaattgg?tagaaaatgc?caagaaaact?gaaaacaaag?actacttcgc?agtcagcgac?360

ggcgttgatg?ttatctacct?tgaaggtcaa?aatgaaaaag?gaaaagaaga?cccacacgct?420

tggcttaacc?ttgaaaacgg?tattattttt?gctaaaaata?tcgccaaaca?attgagcgcc?480

aaagacccta?acaataaaga?attctatgaa?aaaaatctca?aagaatatac?tgataagtta?540

gacaaacttg?ataaagaaag?taaggataaa?tttaataaga?tccctgctga?aaagaaactc?600

attgtaacca?gcgaaggagc?attcaaatac?ttctctaaag?cctatggtgt?cccaagtgct?660

tacatctggg?aaatcaatac?tgaagaagaa?ggaactcctg?aacaaatcaa?gaccttggtt?720

gaaaaacttc?gccaaacaaa?agttccatca?ctctttgtag?aatcaagtgt?ggatgaccgt?780

ccaatgaaaa?ctgtttctca?agacacaaac?atcccaatct?acgctcaaat?ctttactgac?840

tctatcgcag?aacaaggtaa?agaaggcgac?agctactaca?gcatgatgaa?atacaacctt?900

gacaagattg?ctgaaggatt?ggcaaaataa 930

<210>173

<211>1260

<212>DNA

＜213〉streptococcus pneumoniae

<400>173

atggaatggt?ataaaaaaat?cggacttctt?gcaactacag?gtttagcttt?gtttgggctc?60

ggcgcttgct?ccaactatgg?taaatctgcg?gatggcacag?tgaccatcga?gtatttcaac?120

cagaaaaaag?aaatgaccaa?aaccttggaa?gaaatcactc?gtgattttga?gaaggaaaac?180

cctaagatca?aggtcaaagt?cgtcaatgta?ccaaatgctg?gtgaagtatt?gaagacacgc?240

gttctcgcag?gagatgtgcc?tgatgtggtc?aatatttacc?cacagtccat?cgaactgcaa?300

gaatgggcaa?aagcaggtgt?ttttgaagat?ttgagcaaca?aagactacct?gaaacgcgtg?360

aaaaatggct?acgctgaaaa?atatgctgta?aacgaaaaag?tttacaacgt?tccttttaca?420

gctaatgctt?atggaattta?ctacaacaaa?gataaattcg?aagaactggg?cttgaaggtt?480

cctgaaacct?gggatgaatt?tgaacagtta?gtcaaagata?tcgttgctaa?aggacaaaca?540

ccatttggaa?ttgcaggtgc?agatgcttgg?acactcaatg?gttacaatca?attagccttt?600

gcgacagcaa?caggtggagg?aaaagaagca?aatcaatacc?ttcgttattc?tcaaccaaat?660

gccattaaat?tgtcggatcc?gattatgaaa?gatgatatca?aggtcatgga?catccttcgc?720

atcaatggat?ctaagcaaaa?gaactgggaa?ggtgctggct?ataccgatgt?tatcggagcc?780

ttcgcacgtg?gggatgtcct?catgacacca?aatgggtctt?gggcgatcac?agcgattaat?840

gaacaaaaac?cgaactttaa?gattgggacc?ttcatgattc?caggaaaaga?aaaaggacaa?900

agcttaaccg?ttggtgcggg?agacttggca?tggtctatct?cagccaccac?caaacatcca?960

aaagaagcca?atgcctttgt?ggaatatatg?acccgtccag?aagtcatgca?aaaatactac?1020

gatgtggacg?gatctccaac?agcgatcgaa?ggggtcaaac?aagcaggaga?agattcaccg?1080

cttgctggta?tgaccgaata?tgcctttacg?gatcgtcact?tggtctggtt?gcaacaatac?1140

tggaccagtg?aagcagactt?ccataccttg?accatgaact?atgtcttgac?cggtgataaa?1200

caaggcatgg?tcaatgattt?gaatgccttc?tttaacccga?tgaaagcgga?tgtggattag?1260

<210>174

<211>1680

<212>DNA

＜213〉streptococcus pneumoniae

<400>174

atgaagaaaa?tcaaaccgca?tggaccgtta?ccaagtcaga?ctcagctagc?ttatctggga?60

gatgaactag?cagcttttat?ccacttcggt?cctaatacct?tttatgacca?agaatggggg?120

actggacagg?aggatcctga?gcgctttaac?ccgagtcagt?tggatgcgcg?tgagtgggtt?180

cgtgtgctca?aggaaacggg?cttcaaaaag?ttgattttgg?tggtcaagca?ccacgatggc?240

tttgtccttt?atccgacagc?tcacacagat?tattcggtta?aggtcagtcc?ttggaggaga?300

ggaaagggcg?acttgctcct?tgaagtatcc?caagctgcca?cagagtttga?tatggatatg?360

ggggtctacc?tgtcaccgtg?ggatgcccat?agtcccctct?atcatgtgga?ccgagaagcg?420

gactacaatg?cctattatct?ggctcagttg?aaggaaatct?tatcaaatcc?taactatggg?480

aatgctggta?agttcgctga?ggtttggatg?gatggtgcca?gaggagaggg?cgcgcaaaag?540

gttaattatg?aatttgaaaa?atggtttgaa?accattcgtg?acctgcaggg?cgattgcttg?600

attttttcaa?cagaaggcac?cagtatccgc?tggattggca?atgaacgagg?gtatgcaggt?660

gatccactgt?ggcaaaaggt?gaatcctgat?aaactaggaa?cagaagcaga?gctgaactat?720

cttcagcacg?gggatccctc?gggcacgatt?ttttcaatcg?gagaggcaga?tgtttccatc?780

cgtccaggct?ggttctacca?tgaggatcag?gatcctaagt?ctctcgagga?gttggtcgaa?840

atctactttc?actcagtagg?gcgaggaact?ccactcttgc?ttaatattcc?gccgaatcaa?900

gctgggctct?ttgatgcaaa?ggatattgaa?cgactttatg?aatttgcgac?ctatcgcaat?960

gagctctata?aagaagattt?ggctctggga?gctgaggtat?ctggtccagc?tctttccgca?1020

gactttgctt?gtcgccattt?gacagacggc?cttgagacca?gctcttgggc?aagcgatgca?1080

gacttgccca?tccagttaga?actcgactta?ggttctccta?aaacttttga?tgtaattgag?1140

ttaagagaag?atttgaagct?agggcaacga?atcgctgctt?ttcatgtgca?agtagaggtg?1200

gatggtgtct?ggcaggagtt?tggttcgggt?catactgttg?gttacaaacg?tctcttacga?1260

ggagcagttg?ttgaggcaca?gaagatacgt?gtagtcatta?cagaatcaca?ggctttgcct?1320

ttgttgacca?agatttccct?ttataaaact?cctggattat?caaaaaaaga?agttgttcag?1380

gaactagcat?ttgcagaaaa?aagcctagct?gtggcaaagg?gagaaaatgc?ctattttaca?1440

gttaagcgca?gagaatgtag?tggtccttta?gaagctaaga?tttcgattca?accggggaca?1500

ggtgtccatg?gtgtcgccta?tcaggatgag?attcaagtcc?ttgcgtttca?aactggtgag?1560

actgaaaaaa?gtctgacgct?accaaccttg?tatttcgcag?gagataaaac?cttggatttc?1620

tatctgaacc?taacggtgga?tggtcagctt?gtggatcaac?ttcaagtcca?agtttcataa?1680

<210>175

<211>684

<212>DNA

＜213〉streptococcus pneumoniae

<400>175

atgcttgaaa?gactgaaaag?aatacattat?atgttttgga?tcagtttaat?ttttatgatt?60

ttccccatcc?tgtctgtagt?gactgggtgg?ctttctgcct?ggcatttatt?gattgatatt?120

ctatttgtag?tggcatattt?gggtgtttta?acaactaaga?gccagcgcct?atcttggcta?180

tattggggcc?tcatgctgac?ttatgtagtt?gggaatactg?cctttgttgc?tgttaattat?240

atctggtttt?tctttttcct?atccaatctc?ttaagttatc?atttcagcgt?acgtagttta?300

aagtctttac?atgtctggac?ttttcttctt?gctcaagtcc?ttgttgtggg?gcaactgttg?360

atttttcaga?gaatcgaagt?tgagtttcta?ttctatctac?ttgtaattct?tacttttgtc?420

gatttaatga?cttttggatt?ggttcggatt?cgtattgtcg?aggatttgaa?agaagctcag?480

gtcaagcaaa?atgctcagat?aaatctattg?cttgctgaaa?atgaacgtag?tcgtatcggt?540

caggatttgc?atgatagtct?gggacatacc?tttgctatgc?tgagtgtcaa?gacagattta?600

gccttgcagt?tatttcagat?ggaggcttat?ccacaggtgg?aaaaggaatt?aaaagaaatt?660

caccagatca?gcaaggatcc?atga 684

<210>176

<211>1113

<212>DNA

＜213〉streptococcus pneumoniae

<400>176

atgaatgata?agttaaaaat?cttcttgttg?ctaggagtat?tttttctagc?cataaccggt?60

ttctatgttc?tattgatacg?aaatgcaggg?cagacagatg?cctcgcaaat?tgaaaaggcg?120

gcagttagcc?aaggaggaaa?agcagtgaaa?aaaacagaaa?ttagtaaaga?cgcagacttg?180

cacgaaattt?atctagctgg?aggttgtttc?tggggagtgg?aggaatattt?ctcacgtgtt?240

cccggggtga?cggatgccgt?ttcaggctat?gcaaatggta?gaggagaaac?aaccaagtac?300

gaattgatta?accaaacagg?tcatgcagaa?accgtccatg?tcacctatga?tgccaagcaa?360

atttctctca?aggaaatcct?gcttcactat?ttccgcatta?tcaatccaac?cagcaaaaat?420

aaacaaggaa?atgatgtggg?gacccagtac?cgtactggtg?tttattacac?agatgacaag?480

gatttggaag?tgattaacca?agtctttgat?gaggtggcta?agaaatacga?tcaacctcta?540

gcagttgaaa?aggaaaactt?gaagaatttt?gtggtggctg?aggattacca?tcaagactat?600

ctcaagaaaa?atccaaatgg?ctactgccat?atcaatgtta?atcaggcggc?ctatcctgtc?660

attgatgcca?gcaaatatcc?aaaaccaagt?gatgaggaat?tgaaaaagac?cctgtcacct?720

gaggagtatg?cagttaccca?ggaaaatcaa?acagaacgag?ctttctcaaa?ccgttactgg?780

gataaatttg?aatccggtat?ctatgtggat?atagcaactg?gggaacctct?cttttcatca?840

aaagacaaat?ttgagtctgg?ttgtggctgg?cctagtttta?cccaacccat?cagtccagat?900

gttgtcacct?acaaggaaga?taagtcctac?aatatgacgc?gtatggaagt?gcggagccga?960

gtaggagatt?ctcaccttgg?gcatgtcttt?acggatggtc?cacaggacaa?gggcggctta?1020

cgttactgta?tcaatagcct?ctctatccgc?tttattccca?aagaccaaat?ggaagaaaaa?1080

ggctacgctt?atttactaga?ttatgttgat?taa 1113

<210>177

<211>1017

<212>DNA

＜213〉streptococcus pneumoniae

<400>177

atgaaaaaga?aatggatgta?ttatgctgct?tgttcttcta?atgaatctgc?cgatgacagt?60

tcatctgata?aaggagacgg?cggttcgcta?gtcgtttatt?caccaaactc?agagggctta?120

attggagcaa?ctattcctgc?ctttgaagaa?aaatatggta?tcaaagtaga?actgattcaa?180

gctggtactg?gagaactttt?caaaaaacta?gagtcagaaa?aagaagttcc?tgtagctgat?240

gttatctttg?gtggttctta?tacacaatat?actacccacg?gagaactctt?tgaaaactat?300

acttcaaaag?aaaatgataa?tgttatcaaa?gaatatcaaa?acacaactgg?ctactctact?360

ccttatacac?tagatggtag?tgttttaatc?gtcaaccctg?atttaactaa?aggcatgaac?420

atcgaaggat?ataacgatct?tttcaaacct?gaactaaaag?gaaaaatcgc?aactgctgac?480

ccagcaaact?cttctagcgc?ctttgctcaa?ttaacaaata?tgctacaagc?tcaaggtggt?540

tacaaagatg?ataaggcttg?gtcttatgta?aaagatcttt?tcacacttat?tgatggtaaa?600

atcggttcaa?gttcatctag?tgtctataaa?gtagtcgctg?atggagaaat?ggctgttggt?660

ctctcttatg?aagatccagc?agttaaactc?ttaaatgacg?gagctaacat?taaggtagtc?720

tatccaaaag?aaggaaccgt?cttcctacct?gctagtgctg?ctatcgttaa?aaaatctaaa?780

aatatggaaa?atgccaagaa?atttatcgat?tttattatct?ctcaagaagt?acaagataca?840

cttggtacaa?ccactactaa?ccgtcctgtt?cgtaaaaatg?ctaaaacaag?cgaaaacatg?900

aaaccaattg?acaaaatcaa?aacactcact?gaagattatg?attatgtcat?caagaataaa?960

tcagatatcg?ttaagaaata?caacgaagtc?tttacagata?tccaatctaa?acagtaa 1017

<210>178

<211>1092

<212>DNA

＜213〉streptococcus pneumoniae

<400>178

atgagtgaga?tcaaaattat?taacgccaaa?aaaatctacc?acgatgtccc?tgttattgag?60

aatttgaaca?ttacaattcc?aaaaggaagt?ctctttaccc?ttcttggagc?ttcaggatgt?120

gggaaaacga?cccttcttcg?tatgattgca?ggtttcaaca?gtatcgaagg?tggagaattt?180

tacttcgatg?atacaaaaat?caataatatg?gaacccagca?aacgcaatat?cgggatggtt?240

ttccaaaact?acgctatttt?cccacatttg?actgtccgag?acaacgttgc?ttttggtctt?300

atgcaaaaga?aggttccaaa?agaagaattg?attcaacaga?ccaacaagta?tcttgaactc?360

atgcaaattg?ctcaatatgc?ggatcgaaag?cccgataaac?tcagtggtgg?acaacaacaa?420

cgtgtcacct?tggcatgcgc?cttagcggtt?aatccaagtg?ttctcctcat?ggacgagcca?480

cttagtaatc?tggaggccaa?acttcgcttg?gatatgcgtc?aagccatccg?agaaatccaa?540

cacgaagtgg?gaattacaac?tgtttatgta?acccacgacc?aagaagaagc?catggctatt?600

tcagaccaaa?ttgctgttat?gaaagatggg?gtgatccaac?aaatcggccg?accaaaagaa?660

ctctatcata?aaccagctaa?tgagtttgtg?gcaaccttta?tcggacgcac?aaatattatc?720

cctgccaatc?ttgaaaaacg?gagcgacggc?gcttatatcg?tcttttcaga?tggctatgcc?780

cttcgaatgc?cagctcttga?tcaggttgag?gagcaagcta?ttcatgtaag?cattcgtccc?840

gaagagttta?tcaaagatga?atctggagat?attgaaggaa?ctattagaga?tagcgtctat?900

cttggactaa?atacggatta?tttcattgag?acaggttttg?cctcaaaaat?tcaagttagt?960

gaagaatcaa?cttttgaaga?agatctacaa?aaaggcaatc?gtattcgtct?acgaatcaat?1020

acgcaaaaat?taaacatctt?ttctgcagat?ggttcccaaa?acctgataaa?aggagtcaac?1080

catggaacgt?aa 1092

<210>179

<211>942

<212>DNA

＜213〉streptococcus pneumoniae

<400>179

atgaagaaaa?aattattggc?aggtgccatc?acactattat?cagtagcaac?tttagcagct?60

tgttcgaaag?ggtcagaagg?tgcagacctt?atcagcatga?aaggggatgt?cattacagaa?120

catcaatttt?atgagcaagt?gaaaagcaac?ccttcagccc?aacaagtctt?gttaaatatg?180

accatccaaa?aagtttttga?aaaacaatat?ggctcagagc?ttgatgataa?agaggttgat?240

gatactattg?ccgaagaaaa?aaaacaatat?ggcgaaaact?accaacgtgt?cttgtcacaa?300

gcaggtatga?ctcttgaaac?acgtaaagct?caaattcgta?caagtaaatt?agttgagttg?360

gcagttaaga?aggtagcaga?agctgaattg?acagatgaag?cctataagaa?agcctttgat?420

gagtacactc?cagatgtaac?ggctcaaatc?atccgtctta?ataatgaaga?taaggccaaa?480

gaagttctcg?aaaaagccaa?ggcagaaggt?gctgattttg?ctcaattagc?caaagataat?540

tcaactgatg?aaaaaacaaa?agaaaatggt?ggagaaatta?cctttgattc?tgcttcaaca?600

gaagtacctg?agcaagtcaa?aaaagccgct?ttcgctttag?atgtggatgg?tgtttctgat?660

gtgattacag?caactggcac?acaagcctac?agtagccaat?attacattgt?aaaactcact?720

aagaaaacag?aaaaatcatc?taatattgat?gactacaaag?aaaaattaaa?aactgttatc?780

ttgactcaaa?aacaaaatga?ttcaacattt?gttcaaagca?ttatcggaaa?agaattgcaa?840

gcagccaata?tcaaggttaa?ggaccaagcc?ttccaaaata?tctttaccca?atatatcggt?900

ggtggagatt?caagctcaag?cagtagtaca?tcaaacgaat?ag 942

<210>180

<211>1395

<212>DNA

＜213〉streptococcus pneumoniae

<400>180

atgaaaaaaa?atattaaaca?atatgtaacc?ttaggtactg?tagtggtatt?atcageattt?60

gttgctaact?cagttgcagc?tcaggagact?gaaacttctg?aagtatcaac?accaaagttg?120

gtgcaacctg?ttgcaccaac?gactccgatt?tcggaagtac?aacctacatc?ggataactct?180

tcggaagtta?ctgtacaacc?tcgaacagtt?gaaactactg?ttaaggatcc?atcttctaca?240

gcggaagaaa?ctcctgtctt?agaaaaaaat?aatgttactt?taacaggggg?cggagaaaat?300

gttactaaag?agttaaagga?taaatttact?agcggtgact?ttactgtagt?gattaagtac?360

aatcagtcaa?gtgagaaagg?cttacaagct?ctgtttggaa?tatctaattc?caaacccggt?420

caacaaaata?gttatgtaga?tgtgttcctt?agagacaatg?gtgagttggg?gatggaagcg?480

cgtgatactt?cttccaataa?aaataaccta?gtatccagac?ctgcttcagt?ttggggtaag?540

tacaaacaag?aggctgtgac?taacactgtt?gcagtagtag?cagattcagt?caaaaaaaca?600

tattctttat?acgcaaatgg?tacaaaagta?gtagaaaaga?aagtggataa?tttcctaaac?660

atcaaggata?ttaaaggtat?tgattactat?atgcttgggg?gagtgaaacg?tgcaggaaaa?720

acggcgtttg?gttttaacgg?aacactagaa?aatatcaaat?tctttaatag?tgcattggat?780

gaagaaactg?ttaaaaagat?gacaacaaac?gctgttactg?gacatttaat?ttatacggct?840

aatgatacaa?caggttctaa?ctatttccgt?attccagttc?tgtatacttt?tagcaatggt?900

cgggtatttt?caagcattga?cgctcgttac?ggtggaactc?atgatttctt?gaataaaatt?960

aatattgcta?caagttatag?tgatgataat?ggtaagacat?ggactaaacc?aaaattaaca?1020

ttggcattcg?atgattttgc?gccagtacca?ttagaatggc?ctcgtgaagt?tggtggacgt?1080

gacttacaaa?tcagcggtgg?tgcaacctat?attgactctg?ttattgttga?aaaaaagaac?1140

aaacaagtac?tcatgtttgc?tgatgtgatg?cctgctggag?taagttttag?agaagcaact?1200

agaaaagatt?caggttataa?acaaattgat?ggtaattatt?accttaaatt?aaggaaacaa?1260

ggtgatactg?attacaatta?tactattcgt?gagaatggta?ctgtatacga?cgatcgtacc?1320

aacagaccaa?ctgaattttc?agtagataaa?aatttcggta?ttaaacaaaa?tggtaattat?1380

ttgacggtag?agcgg 1395

<210>181

<211>801

<212>DNA

＜213〉streptococcus pneumoniae

<400>181

atgaaaaaat?ttagcctatt?actagctatc?ctaccatttt?tggttgcctg?tgagaatcaa?60

gctacaccca?aagagactag?cgctcaaaag?acaatcgtcc?ttgctacagc?tggcgacgtg?120

ccaccatttg?actacgaaga?caagggcaat?ctgacaggct?ttgatatcga?agttttaaag?180

gcagtagatg?aaaaactcag?cgactacgag?attcaattcc?aaagaaccgc?ctgggagagc?240

atcttcccag?gacttgattc?tggtcactat?caggctgcgg?ccaataactt?gagttacaca?300

aaagagcgtg?ctgaaaaata?cctttactcg?cttccaattt?ccaacaatcc?cctcgtcctt?360

gtcagcaaca?agaaaaatcc?tttgacttct?cttgaccaga?tcgctggtaa?aacaacacaa?420

gaggataccg?gaacttctaa?cgctcaattc?atcaataact?ggaatcagaa?acacactgat?480

aatcccgcta?caattaattt?ttctggtgag?gatattggta?aacgaatcct?agaccttgct?540

aacggagagt?ttgatttcct?agtttttgac?aaggtatccg?ttcaaaagat?tatcaaggac?600

cgtggtttag?acctctcagt?cgttgattta?ccttctgcag?atagccccag?caattatatc?660

attttctcaa?gcgaccaaaa?agagtttaaa?gagcaatttg?ataaagcgct?caaagaactc?720

tatcaagacg?gaacccttga?aaaactcagc?aatacctatc?taggtggttc?ttacctccca?780

gatcaatctc?agttacaata?a 801

<210>182

<211>780

<212>DNA

＜213〉streptococcus pneumoniae

<400>182

atgaaaaaaa?atagtttata?tatcatatcc?tcactctttt?ttgcttgtgt?cttatttgtc?60

tatgctacgg?cgacgaattt?tcaaaacagt?accagtgcta?ggcaggtaaa?aacggaaacc?120

tatactaata?cagtaacaaa?tgtccctatt?gacatacgct?ataatagtga?taagtatttt?180

attagcggtt?ttgcttcaga?agtatcagtg?gtcttgactg?gtgcaaatcg?cctatcgcta?240

gctagtgaaa?tgcaagaaag?tacacgtaaa?ttcaaggtta?ctgctgacct?aacagatgcc?300

ggtgttggaa?cgattgaagt?tcctttgagc?attgaagatt?tacccaatgg?gctgaccgct?360

gtggcgactc?cgcaaaaaat?tacagtcaag?attggtaaga?aggctcagaa?ggataaggta?420

aagattgtac?cagagattga?ccctagtcaa?attgatagtc?gggtacaaat?tgaaaatgtc?480

atggtgtcag?ataaagaagt?gtctattacg?agtgaccaag?agacattgga?tagaattgat?540

aagattatcg?ctgttttgcc?aactagcgaa?cgtataacag?gtaattacag?tggttcagta?600

cctttgcagg?caatcgaccg?caatggtgtt?gtcttaccgg?cagttatcac?tccgtttgat?660

acaataatga?aggtgactac?aaaaccagta?gcaccaagtt?caagcacatc?aaattcaagt?720

acaagcagtt?catcggagac?atcttcgtca?acgaaagcaa?ctagttcaaa?aacgaattaa?780

<210>183

<211>792

<212>DNA

＜213〉streptococcus pneumoniae

<400>183

atgttgattg?gcgaagggta?tcggactttc?cctgtcctga?tttataccca?atttattagc?60

gaggttggag?gaaattctgc?ttttgcaatt?atggcgatta?tcattgcctt?ggcaattttc?120

cttatccaaa?aacacattgc?aaaccgctac?agtttcagca?tgaatctgct?ccatccaatt?180

gagcctaaaa?aaactacaaa?aggaaaaatg?gctgccattt?atgcaacagt?ctacggaatt?240

atctttatct?ctgttttacc?tcaaatctac?ttaatttata?cctctttcct?aaaaacatca?300

ggtatggtat?ctgttaaagg?ttattctcca?aacagttaca?aggtagcttt?ccatcgtatg?360

ggatctgcta?ttttcaatac?cattcgtatc?cctttgattg?ccttagttct?agttgttcta?420

tttgcgacat?ttatctccta?cctagccgtt?agaaaacgga?atttgtttac?aaacttaatt?480

gacagcctca?gtatggtacc?ttatattgta?ccaggaaccg?ttctagggat?tgccttcatt?540

tcttccttca?atactggtct?atttggaagt?ggatttctta?tgattacagg?gactgctttc?600

atcttgatta?tgtctctatc?tgccagaaga?ttaccttata?ctattcgctc?atctgttgct?660

agcttacaac?aaatagcacc?aagtattgaa?gaagctgctg?aaagcttagg?aagtagtcgt?720

ctcaatacct?ttgctaagat?tacaactcca?atgatgctat?ctggtatcat?ttctggagcc?780

atcttatctt?ga 792

<210>184

<211>744

<212>PRT

＜213〉streptococcus pneumoniae

<400>184

Met?Asn?Lys?Lys?Lys?Met?Ile?Leu?Thr?Ser?Leu?Ala?Ser?Val?Ala?Ile

1 5 10 15

Leu?Gly?Ala?Gly?Phe?Val?Thr?Ser?Gln?Pro?Thr?Phe?Val?Arg?Ala?Glu

20 25 30

Glu?Ser?Pro?Gln?Val?Val?Glu?Lys?Ser?Ser?Leu?Glu?Lys?Lys?Tyr?Glu

35 40 45

Glu?Ala?Lys?Ala?Lys?Ala?Asp?Thr?Ala?Lys?Lys?Asp?Tyr?Glu?Thr?Ala

50 55 60

Lys?Lys?Lys?Ala?Glu?Asp?Ala?Gln?Lys?Lys?Tyr?Glu?Asp?Asp?Gln?Lys

65 70 75 80

Arg?Thr?Glu?Glu?Lys?Ala?Arg?Lys?Glu?Ala?Glu?Ala?Ser?Gln?Lys?Leu

85 90 95

Asn?Asp?Val?Ala?Leu?Val?Val?Gln?Asn?Ala?Tyr?Lys?Glu?Tyr?Arg?Glu

100 105 110

Val?Gln?Asn?Gln?Arg?Ser?Lys?Tyr?Lys?Ser?Asp?Ala?Glu?Tyr?Gln?Lys

115 120 125

Lys?Leu?Thr?Glu?Val?Asp?Ser?Lys?Ile?Glu?Lys?Ala?Arg?Lys?Glu?Gln

130 135 140

Gln?Asp?Leu?Gln?Asn?Lys?Phe?Asn?Glu?Val?Arg?Ala?Val?Val?Val?Pro

145 150 155 160

Glu?Pro?Asn?Ala?Leu?Ala?Glu?Thr?Lys?Lys?Lys?Ala?Glu?Glu?Ala?Lys

165 170 175

Ala?Glu?Glu?Lys?Val?Ala?Lys?Arg?Lys?Tyr?Asp?Tyr?Ala?Thr?Leu?Lys

180 185 190

Val?Ala?Leu?Ala?Lys?Lys?Glu?Val?Glu?Ala?Lys?Glu?Leu?Glu?Ile?Glu

195 200 205

Lys?Leu?Gln?Tyr?Glu?Ile?Ser?Thr?Leu?Glu?Gln?Glu?Val?Ala?Thr?Ala

210 215 220

Gln?His?Gln?Val?Asp?Asn?Leu?Lys?Lys?Leu?Leu?Ala?Gly?Ala?Asp?Pro

225 230 235 240

Asp?Asp?Gly?Thr?Glu?Val?Ile?Glu?Ala?Lys?Leu?Lys?Lys?Gly?Glu?Ala

245 250 255

Glu?Leu?Asn?Ala?Lys?Gln?Ala?Glu?Leu?Ala?Lys?Lys?Gln?Thr?Glu?Leu

260 265 270

Glu?Lys?Leu?Leu?Asp?Ser?Leu?Asp?Pro?Glu?Gly?Lys?Thr?Gln?Asp?Glu

275 280 285

Leu?Asp?Lys?Glu?Ala?Glu?Glu?Ala?Glu?Leu?Asp?Lys?Lys?Ala?Asp?Glu

290 295 300

Leu?Gln?Asn?Lys?Val?Ala?Asp?Leu?Glu?Lys?Glu?Ile?Ser?Asn?Leu?Glu

305 310 315 320

Ile?Leu?Leu?Gly?Gly?Ala?Asp?Pro?Glu?Asp?Asp?Thr?Ala?Ala?Leu?Gln

325 330 335

Asn?Lys?Leu?Ala?Ala?Lys?Lys?Ala?Glu?Leu?Ala?Lys?Lys?Gln?Thr?Glu

340 345 350

Leu?Glu?Lys?Leu?Leu?Asp?Ser?Leu?Asp?Pro?Glu?Gly?Lys?Thr?Gln?Asp

355 360 365

Glu?Leu?Asp?Lys?Glu?Ala?Glu?Glu?Ala?Glu?Leu?Asp?Lys?Lys?Ala?Asp

370 375 380

Glu?Leu?Gln?Asn?Lys?Val?Ala?Asp?Leu?Glu?Lys?Glu?Ile?Ser?Asn?Leu

385 390 395 400

Glu?Ile?Leu?Leu?Gly?Gly?Ala?Asp?Ser?Glu?Asp?Asp?Thr?Ala?Ala?Leu

405 410 415

Gln?Asn?Lys?Leu?Ala?Thr?Lys?Lys?Ala?Glu?Leu?Glu?Lys?Thr?Gln?Lys

420 425 430

Glu?Leu?Asp?Ala?Ala?Leu?Asn?Glu?Leu?Gly?Pro?Asp?Gly?Asp?Glu?Glu

435 440 445

Glu?Thr?Pro?Ala?Pro?Ala?Pro?Gln?Pro?Glu?Gln?Pro?Ala?Pro?Ala?Pro

450 455 460

Lys?Pro?Glu?Gln?Pro?Ala?Pro?Ala?Pro?Lys?Pro?Glu?Gln?Pro?Ala?Pro

465 470 475 480

Ala?Pro?Lys?Pro?Glu?Gln?Pro?Ala?Pro?Ala?Pro?Lys?Pro?Glu?Gln?Pro

485 490 495

Ala?Pro?Ala?Pro?Lys?Pro?Glu?Gln?Pro?Ala?Lys?Pro?Glu?Lys?Pro?Ala

500 505 510

Glu?Glu?Pro?Thr?Gln?Pro?Glu?Lys?Pro?Ala?Thr?Pro?Lys?Thr?Gly?Trp

515 520 525

Lys?Gln?Glu?Asn?Gly?Met?Trp?Tyr?Phe?Tyr?Asn?Thr?Asp?Gly?Ser?Met

530 535 540

Ala?Ile?Gly?Trp?Leu?Gln?Asn?Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn?Ala

545 550 555 560

Asn?Gly?Ala?Met?Ala?Thr?Gly?Trp?Val?Lys?Asp?Gly?Asp?Thr?Trp?Tyr

565 570 575

Tyr?Leu?Glu?Ala?Ser?Gly?Ala?Met?Lys?Ala?Ser?Gln?Trp?Phe?Lys?Val

580 585 590

Ser?Asp?Lys?Trp?Tyr?Tyr?Val?Asn?Ser?Asn?Gly?Ala?Met?Ala?Thr?Gly

595 600 605

Trp?Leu?Gln?Tyr?Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn?Ala?Asn?Gly?Asp

610 615 620

Met?Ala?Thr?Gly?Trp?Leu?Gln?Tyr?Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn

625 630 635 640

Ala?Asn?Gly?Asp?Met?Ala?Thr?Gly?Trp?Ala?Lys?Val?Asn?Gly?Ser?Trp

645 650 655

Tyr?Tyr?Leu?Asn?Ala?Asn?Gly?Ala?Met?Ala?Thr?Gly?Trp?Ala?Lys?Val

660 665 670

Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn?Ala?Asn?Gly?Ser?Met?Ala?Thr?Gly

675 680 685

Trp?Val?Lys?Asp?Gly?Asp?Thr?Trp?Tyr?Tyr?Leu?Glu?Ala?Ser?Gly?Ala

690 695 700

Met?Lys?Ala?Ser?Gln?Trp?Phe?Lys?Val?Ser?Asp?Lys?Trp?Tyr?Tyr?Val

705 710 715 720

Asn?Gly?Leu?Gly?Ala?Leu?Ala?Val?Asn?Thr?Thr?Val?Asp?Gly?Tyr?Lys

725 730 735

Val?Asn?Ala?Asn?Gly?Glu?Trp?Val

740

<210>185

<211>693

<212>PRT

＜213〉streptococcus pneumoniae

<400>185

Met?Phe?Ala?Ser?Lys?Ser?Glu?Arg?Lys?Val?His?Tyr?Ser?Ile?Arg?Lys

1 5 10 15

Phe?Ser?Val?Gly?Val?Ala?Ser?Val?Val?Val?Ala?Ser?Leu?Val?Met?Gly

20 25 30

Ser?Val?Val?His?Ala?Thr?Glu?Asn?Glu?Gly?Ala?Thr?Gln?Val?Pro?Thr

35 40 45

Ser?Ser?Asn?Arg?Ala?Asn?Glu?Ser?Gln?Ala?Glu?Gln?Gly?Glu?Gln?Pro

50 55 60

Lys?Lys?Leu?Asp?Ser?Glu?Arg?Asp?Lys?Ala?Arg?Lys?Glu?Val?Glu?Glu

65 70 75 80

Tyr?Val?Lys?Lys?Ile?Val?Gly?Glu?Ser?Tyr?Ala?Lys?Ser?Thr?Lys?Lys

85 90 95

Arg?His?Thr?Ile?Thr?Val?Ala?Leu?Val?Asn?Glu?Leu?Asn?Asn?Ile?Lys

100 105 110

Asn?Glu?Tyr?Leu?Asn?Lys?Ile?Val?Glu?Ser?Thr?Ser?Glu?Ser?Gln?Leu

115 120 125

Gln?Ile?Leu?Met?Met?Glu?Ser?Arg?Ser?Lys?Val?Asp?Glu?Ala?Val?Ser

130 135 140

Lys?Phe?Glu?Lys?Asp?Ser?Ser?Ser?Ser?Ser?Ser?Ser?Asp?Ser?Ser?Thr

145 150 155 160

Lys?Pro?Glu?Ala?Ser?Asp?Thr?Ala?Lys?Pro?Asn?Lys?Pro?Thr?Glu?Pro

165 170 175

Gly?Glu?Lys?Val?Ala?Glu?Ala?Lys?Lys?Lys?Val?Glu?Glu?Ala?Glu?Lys

180 185 190

Lys?Ala?Lys?Asp?Gln?Lys?Glu?Glu?Asp?Arg?Arg?Asn?Tyr?Pro?Thr?Ile

195 200 205

Thr?Tyr?Lys?Thr?Leu?Glu?Leu?Glu?Ile?Ala?Glu?Ser?Asp?Val?Glu?Val

210 215 220

Lys?Lys?Ala?Glu?Leu?Glu?Leu?Val?Lys?Val?Lys?Ala?Asn?Glu?Pro?Arg

225 230 235 240

Asp?Glu?Gln?Lys?Ile?Lys?Gln?Ala?Glu?Ala?Glu?Val?Glu?Ser?Lys?Gln

245 250 255

Ala?Glu?Ala?Thr?Arg?Leu?Lys?Lys?Ile?Lys?Thr?Asp?Arg?Glu?Glu?Ala

260 265 270

Glu?Glu?Glu?Ala?Lys?Arg?Arg?Ala?Asp?Ala?Lys?Glu?Gln?Gly?Lys?Pro

275 280 285

Lys?Gly?Arg?Ala?Lys?Arg?Gly?Val?Pro?Gly?Glu?Leu?Ala?Thr?Pro?Asp

290 295 300

Lys?Lys?Glu?Asn?Asp?Ala?Lys?Ser?Ser?Asp?Ser?Ser?Val?Gly?Glu?Glu

305 310 315 320

Thr?Leu?Pro?Ser?Pro?Ser?Leu?Lys?Pro?Glu?Lys?Lys?Val?Ala?Glu?Ala

325 330 335

Glu?Lys?Lys?Val?Glu?Glu?Ala?Lys?Lys?Lys?Ala?Glu?Asp?Gln?Lys?Glu

340 345 350

Glu?Asp?Arg?Arg?Asn?Tyr?Pro?Thr?Asn?Thr?Tyr?Lys?Thr?Leu?Glu?Leu

355 360 365

Glu?Ile?Ala?Glu?Ser?Asp?Val?Glu?Val?Lys?Lys?Ala?Glu?Leu?Glu?Leu

370 375 380

Val?Lys?Glu?Glu?Ala?Lys?Glu?Pro?Arg?Asn?Glu?Glu?Lys?Val?Lys?Gln

385 390 395 400

Ala?Lys?Ala?Glu?Val?Glu?Ser?Lys?Lys?Ala?Glu?Ala?Thr?Arg?Leu?Glu

405 410 415

Lys?Ile?Lys?Thr?Asp?Arg?Lys?Lys?Ala?Glu?Glu?Glu?Ala?Lys?Arg?Lys

420 425 430

Ala?Ala?Glu?Glu?Asp?Lys?Val?Lys?Glu?Lys?Pro?Ala?Glu?Gln?Pro?Gln

435 440 445

Pro?Ala?Pro?Ala?Pro?Lys?Ala?Glu?Lys?Pro?Ala?Pro?Ala?Pro?Lys?Pro

450 455 460

Glu?Asn?Pro?Ala?Glu?Gln?Pro?Lys?Ala?Glu?Lys?Pro?Ala?Asp?Gln?Gln

465 470 475 480

Ala?Glu?Glu?Asp?Tyr?Ala?Arg?Arg?Ser?Glu?Glu?Glu?Tyr?Asn?Arg?Leu

485 490 495

Thr?Gln?Gln?Gln?Pro?Pro?Lys?Thr?Glu?Lys?Pro?Ala?Gln?Pro?Ser?Thr

500 505 510

Pro?Lys?Thr?Gly?Trp?Lys?Gln?Glu?Asn?Gly?Met?Trp?Tyr?Phe?Tyr?Asn

515 520 525

Thr?Asp?Gly?Ser?Met?Ala?Thr?Gly?Trp?Leu?Gln?Asn?Asn?Gly?Ser?Trp

530 535 540

Tyr?Tyr?Leu?Asn?Ser?Asn?Gly?Ala?Met?Ala?Thr?Gly?Trp?Leu?Gln?Asn

545 550 555 560

Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn?Ala?Asn?Gly?Ser?Met?Ala?Thr?Gly

565 570 575

Trp?Leu?Gln?Asn?Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn?Ala?Asn?Gly?Ser

580 585 590

Met?Ala?Thr?Gly?Trp?Leu?Gln?Tyr?Asn?Gly?Ser?Trp?Tyr?Tyr?Leu?Asn

595 600 605

Ala?Asn?Gly?Ser?Met?Ala?Thr?Gly?Trp?Leu?Gln?Tyr?Asn?Gly?Ser?Trp

610 615 620

Tyr?Tyr?Leu?Asn?Ala?Asn?Gly?Asp?Met?Ala?Thr?Gly?Trp?Val?Lys?Asp

625 630 635 640

Gly?Asp?Thr?Trp?Tyr?Tyr?Leu?Glu?Ala?Ser?Gly?Ala?Met?Lys?Ala?Ser

645 650 655

Gln?Trp?Phe?Lys?Val?Ser?Asp?Lys?Trp?Tyr?Tyr?Val?Asn?Gly?Ser?Gly

660 665 670

Ala?Leu?Ala?Val?Asn?Thr?Thr?Val?Asp?Gly?Tyr?Gly?Val?Asn?Ala?Asn

675 680 685

Gly?Glu?Trp?Val?Asn

690

<210>186

<211>129

<212>PRT

＜213〉streptococcus pneumoniae

<400>186

Met?Val?Lys?Arg?Arg?Ile?Arg?Arg?Gly?Thr?Arg?Glu?Pro?Glu?Lys?Val

1 5 10 15

Val?Val?Pro?Glu?Gln?Ser?Ser?Ile?Pro?Ser?Tyr?Pro?Val?Ser?Val?Thr

20 25 30

Ser?Asn?Gln?Gly?Thr?Asp?Val?Ala?Val?Glu?Pro?Ala?Lys?Ala?Val?Ala

35 40 45

Pro?Thr?Thr?Asp?Trp?Lys?Gln?Glu?Asn?Gly?Met?Trp?Tyr?Phe?Tyr?Asn

50 55 60

Thr?Asp?Gly?Ser?Met?Ala?Thr?Gly?Trp?Val?Gln?Val?Asn?Ser?Ser?Trp

65 70 75 80

Tyr?Tyr?Leu?Asn?Ser?Asn?Gly?Ser?Met?Lys?Val?Asn?Gln?Trp?Phe?Gln

85 90 95

Val?Gly?Gly?Lys?Trp?Tyr?Tyr?Val?Asn?Thr?Ser?Gly?Glu?Leu?Ala?Val

100 105 110

Asn?Thr?Ser?Ile?Asp?Gly?Tyr?Arg?Val?Asn?Asp?Asn?Gly?Glu?Trp?Val

115 120 125

Arg

<210>187

<211>230

<212>PRT

＜213〉streptococcus pneumoniae

<400>187

Leu?Asn?Thr?Ser?Phe?Val?His?Ala?Ala?Asp?Gly?Ile?Gln?Tyr?Val?Arg

1 5 10 15

Asp?Asp?Thr?Arg?Asp?Lys?Glu?Glu?Gly?Ile?Glu?Tyr?Asp?Asp?Ala?Asp

20 25 30

Asn?Gly?Asp?Ile?Ile?Val?Lys?Val?Ala?Thr?Lys?Pro?Lys?Val?Val?Thr

35 40 45

Lys?Lys?Ile?Ser?Ser?Thr?Arg?Ile?Arg?Tyr?Glu?Lys?Asp?Glu?Thr?Lys

50 55 60

Asp?Arg?Ser?Glu?Asn?Pro?Val?Thr?Ile?Asp?Gly?Glu?Asp?Gly?Tyr?Val

65 70 75 80

Thr?Thr?Thr?Arg?Thr?Tyr?Asp?Val?Asn?Pro?Glu?Thr?Gly?Tyr?Val?Thr

85 90 95

Glu?Gln?Val?Thr?Val?Asp?Arg?Lys?Glu?Ala?Thr?Asp?Thr?Val?Ile?Lys

100 105 110

Val?Pro?Ala?Lys?Ser?Lys?Val?Glu?Glu?Val?Leu?Val?Pro?Phe?Ala?Thr

115 120 125

Lys?Tyr?Glu?Ala?Asp?Asn?Asp?Leu?Ser?Ala?Gly?Gln?Glu?Gln?Glu?Ile

130 135 140

Thr?Leu?Gly?Lys?Asn?Gly?Lys?Thr?Val?Thr?Thr?Ile?Thr?Tyr?Asn?Val

145 150 155 160

Asp?Gly?Lys?Ser?Gly?Gln?Val?Thr?Glu?Ser?Thr?Leu?Ser?Gln?Lys?Lys

165 170 175

Asp?Ser?Gln?Thr?Arg?Val?Val?Lys?Lys?Arg?Thr?Lys?Pro?Gln?Val?Leu

180 185 190

Val?Gln?Glu?Ile?Pro?Ile?Glu?Thr?Glu?Tyr?Leu?Asp?Gly?Pro?Thr?Leu

195 200 205

Asp?Lys?Ser?Gln?Glu?Val?Glu?Glu?Val?Gly?Glu?Ile?Gly?Lys?Leu?Leu

210 215 220

Leu?Leu?Gln?Ser?Ile?Leu

225 230

<210>188

<211>340

<212>PRT

＜213〉streptococcus pneumoniae

<400>188

Met?Lys?Leu?Leu?Lys?Lys?Met?Met?Gln?Ile?Ala?Leu?Ala?Thr?Phe?Phe

1 5 10 15

Phe?Gly?Leu?Leu?Ala?Thr?Asn?Thr?Val?Phe?Ala?Asp?Asp?Ser?Glu?Gly

20 25 30

Trp?Gln?Phe?Val?Gln?Glu?Asn?Gly?Arg?Thr?Tyr?Tyr?Lys?Lys?Gly?Asp

35 40 45

Leu?Lys?Glu?Thr?Tyr?Trp?Arg?Val?Ile?Asp?Gly?Lys?Tyr?Tyr?Tyr?Phe

50 55 60

Asp?Pro?Leu?Ser?Gly?Glu?Met?Val?Val?Gly?Trp?Gln?Tyr?Ile?Pro?Ala

65 70 75 80

Pro?His?Lys?Gly?Val?Thr?Ile?Gly?Pro?Ser?Pro?Arg?Ile?Glu?Ile?Ala

85 90 95

Leu?Arg?Pro?Asp?Trp?Phe?Tyr?Phe?Gly?Gln?Asp?Gly?Val?Leu?Gln?Glu

100 105 110

Phe?Val?Gly?Lys?Gln?Val?Leu?Glu?Ala?Lys?Thr?Ala?Thr?Asn?Thr?Asn

115 120 125

Lys?His?His?Gly?Glu?Glu?Tyr?Asp?Ser?Gln?Ala?Glu?Lys?Arg?Val?Tyr

130 135 140

Tyr?Phe?Glu?Asp?Gln?Arg?Ser?Tyr?His?Thr?Leu?Lys?Thr?Gly?Trp?Ile

145 150 155 160

Tyr?Glu?Glu?Gly?His?Trp?Tyr?Tyr?Leu?Gln?Lys?Asp?Gly?Gly?Phe?Asp

165 170 175

Ser?Arg?Ile?Asn?Arg?Leu?Thr?Val?Gly?Glu?Leu?Ala?Arg?Gly?Trp?Val

180 185 190

Lys?Asp?Tyr?Pro?Leu?Thr?Tyr?Asp?Glu?Glu?Lys?Leu?Lys?Ala?Ala?Pro

195 200 205

Trp?Tyr?Tyr?Leu?Asn?Pro?Ala?Thr?Gly?Ile?Met?Gln?Thr?Gly?Trp?Gln

210 215 220

Tyr?Leu?Gly?Asn?Arg?Trp?Tyr?Tyr?Leu?His?Ser?Ser?Gly?Ala?Met?Ala

225 230 235 240

Thr?Gly?Trp?Tyr?Lys?Glu?Gly?Ser?Thr?Trp?Tyr?Tyr?Leu?Asp?Ala?Glu

245 250 255

Asn?Gly?Asp?Met?Arg?Thr?Gly?Trp?Gln?Asn?Leu?Gly?Asn?Lys?Trp?Tyr

260 265 270

Tyr?Leu?Arg?Ser?Ser?Gly?Ala?Met?Ala?Thr?Gly?Trp?Tyr?Gln?Glu?Ser

275 280 285

Ser?Thr?Trp?Tyr?Tyr?Leu?Asn?Ala?Ser?Asn?Gly?Asp?Mer?Lys?Thr?Gly

290 295 300

Trp?Phe?Gln?Val?Asn?Gly?Asn?Trp?Tyr?Tyr?Ala?Tyr?Asp?Ser?Gly?Ala

305 310 315 320

Leu?Ala?Val?Asn?Thr?Thr?Val?Gly?Gly?Tyr?Tyr?Leu?Asn?Tyr?Asn?Gly

325 330 335

Glu?Trp?Val?Lys

340

<210>189

<211>181

<212>PRT

＜213〉streptococcus pneumoniae

<400>189

Leu?Ala?Gly?Arg?Tyr?Gly?Ser?Ala?Val?Gln?Cys?Thr?Glu?Val?Thr?Ala

1 5 10 15

Ser?Asn?Leu?Ser?Thr?Val?Lys?Thr?Lys?Ala?Thr?Val?Val?Glu?Lys?Pro

20 25 30

Leu?Lys?Asp?Phe?Arg?Ala?Ser?Thr?Ser?Asp?Gln?Ser?Gly?Trp?Val?Glu

35 40 45

Ser?Asn?Gly?Lys?Trp?Tyr?Phe?Tyr?Glu?Ser?Gly?Asp?Val?Lys?Thr?Gly

50 55 60

Trp?Val?Lys?Thr?Asp?Gly?Lys?Trp?Tyr?Tyr?Leu?Asn?Asp?Leu?Gly?Val

65 70 75 80

Met?Gln?Thr?Gly?Phe?Val?Lys?Phe?Ser?Gly?Ser?Trp?Tyr?Tyr?Leu?Ser

85 90 95

Asn?Ser?Gly?Ala?Met?Phe?Thr?Gly?Trp?Gly?Thr?Asp?Gly?Ser?Arg?Trp

100 105 110

Phe?Tyr?Phe?Asp?Gly?Ser?Gly?Ala?Met?Lys?Thr?Gly?Trp?Tyr?Lys?Glu

115 120 125

Asn?Gly?Thr?Trp?Tyr?Tyr?Leu?Asp?Glu?Ala?Gly?Ile?Met?Lys?Thr?Gly

130 135 140

Trp?Phe?Lys?Val?Gly?Pro?His?Trp?Tyr?Tyr?Ala?Tyr?Gly?Ser?Gly?Ala

145 150 155 160

Leu?Ala?Val?Ser?Thr?Thr?Thr?Pro?Asp?Gly?Tyr?Arg?Val?Asn?Gly?Asn

165 170 175

Gly?Glu?Trp?Val?Asn

180

<210>190

<211>332

<212>PRT

＜213〉streptococcus pneumoniae

<400>190

Met?Lys?Ile?Leu?Lys?Lys?Thr?Met?Gln?Val?Gly?Leu?Thr?Val?Phe?Phe

1 5 10 15

Phe?Gly?Leu?Leu?Gly?Thr?Ser?Thr?Val?Phe?Ala?Asp?Asp?Ser?Glu?Gly

20 25 30

Trp?Gln?Phe?Val?Gln?Glu?Asn?Gly?Arg?Thr?Tyr?Tyr?Lys?Lys?Gly?Asp

35 40 45

Leu?Lys?Glu?Thr?Tyr?Trp?Arg?Val?Ile?Asp?Gly?Lys?Tyr?Tyr?Tyr?Phe

50 55 60

Asp?Ser?Leu?Ser?Gly?Glu?Met?Val?Val?Gly?Trp?Gln?Tyr?Ile?Pro?Phe

65 70 75 80

Pro?Ser?Lys?Gly?Ser?Thr?Ile?Gly?Pro?Tyr?Pro?Asn?Gly?Ile?Arg?Leu

85 90 95

Glu?Gly?Phe?Pro?Lys?Ser?Glu?Trp?Tyr?Tyr?Phe?Asp?Lys?Asn?Gly?Val

100 105 110

Leu?Gln?Glu?Phe?Val?Gly?Trp?Lys?Thr?Leu?Glu?Ile?Lys?Thr?Lys?Asp

115 120 125

Ser?Val?Gly?Arg?Lys?Tyr?Gly?Glu?Lys?Arg?Glu?Asp?Ser?Glu?Asp?Lys

130 135 140

Glu?Glu?Lys?Arg?Tyr?Tyr?Thr?Asn?Tyr?Tyr?Phe?Asn?Gln?Asn?His?Ser

145 150 155 160

Leu?Glu?Thr?Gly?Trp?Leu?Tyr?Asp?Gln?Ser?Asn?Trp?Tyr?Tyr?Leu?Ala

165 170 175

Lys?Thr?Glu?Ile?Asn?Gly?Glu?Asn?Tyr?Leu?Gly?Gly?Glu?Arg?Arg?Ala

180 185 190

Gly?Trp?Ile?Asn?Asp?Asp?Ser?Thr?Trp?Tyr?Tyr?Leu?Asp?Pro?Thr?Thr

195 200 205

Gly?Ile?Met?Gln?Thr?Gly?Trp?Gln?Tyr?Leu?Gly?Asn?Lys?Trp?Tyr?Tyr

210 215 220

Leu?Arg?Ser?Ser?Gly?Ala?Met?Ala?Thr?Gly?Trp?Tyr?Gln?Glu?Gly?Thr

225 230 235 240

Thr?Trp?Tyr?Tyr?Leu?Asp?His?Pro?Asn?Gly?Asp?Met?Lys?Thr?Gly?Trp

245 250 255

Gln?Asn?Leu?Gly?Asn?Lys?Trp?Tyr?Tyr?Leu?Arg?Ser?Ser?Gly?Ala?Met

260 265 270

Ala?Thr?Gly?Trp?Tyr?Gln?Asp?Gly?Ser?Thr?Trp?Tyr?Tyr?Leu?Asn?Ala

275 280 285

Gly?Asn?Gly?Asp?Met?Lys?Thr?Gly?Trp?Phe?Gln?Val?Asn?Gly?Asn?Trp

290 295 300

Tyr?Tyr?Ala?Tyr?Ser?Ser?Gly?Ala?Leu?Ala?Val?Asn?Thr?Thr?Val?Asp

305 310 315 320

Gly?Tyr?Ser?Val?Asn?Tyr?Asn?Gly?Glu?Trp?Val?Arg

325 330

<210>191

<211>627

<212>PRT

＜213〉streptococcus pneumoniae

<400>191

Met?Lys?Lys?Lys?Leu?Thr?Ser?Leu?Ala?Leu?Val?Gly?Ala?Phe?Leu?Gly

1 5 10 15

Leu?Ser?Trp?Tyr?Gly?Asn?Val?Gln?Ala?Gln?Glu?Ser?Ser?Gly?Asn?Lys

20 25 30

Ile?His?Phe?Ile?Asn?Val?Gln?Glu?Gly?Gly?Ser?Asp?Ala?Ile?Ile?Leu

35 40 45

Glu?Ser?Asn?Gly?His?Phe?Ala?Met?Val?Asp?Thr?Gly?Glu?Asp?Tyr?Asp

50 55 60

Phe?Pro?Asp?Gly?Ser?Asp?Ser?Arg?Tyr?Pro?Trp?Arg?Glu?Gly?Ile?Glu

65 70 75 80

Thr?Ser?Tyr?Lys?His?Val?Leu?Thr?Asp?Arg?Val?Phe?Arg?Arg?Leu?Lys

85 90 95

Glu?Leu?Gly?Val?Gln?Lys?Leu?Asp?Phe?Ile?Leu?Val?Thr?His?Thr?His

100 105 110

Ser?Asp?His?Ile?Gly?Asn?Val?Asp?Glu?Leu?Leu?Ser?Thr?Tyr?Pro?Val

115 120 125

Asp?Arg?Val?Tyr?Leu?Lys?Lys?Tyr?Ser?Asp?Ser?Arg?Ile?Thr?Asn?Ser

130 135 140

Glu?Arg?Leu?Trp?Asp?Asn?Leu?Tyr?Gly?Tyr?Asp?Lys?Val?Leu?Gln?Thr

145 150 155 160

Ala?Ala?Glu?Lys?Gly?Val?Ser?Val?Ile?Gln?Asn?Ile?Thr?Gln?Gly?Asp

165 170 175

Ala?His?Phe?Gln?Phe?Gly?Asp?Met?Asp?Ile?Gln?Leu?Tyr?Asn?Tyr?Glu

180 185 190

Asn?Glu?Thr?Asp?Ser?Ser?Gly?Glu?Leu?Lys?Lys?Ile?Trp?Asp?Asp?Asn

195 200 205

Ser?Asn?Ser?Leu?Ile?Ser?Val?Val?Lys?Val?Asn?Gly?Lys?Lys?Ile?Tyr

210 215 220

Leu?Gly?Gly?Asp?Leu?Asp?Asn?Val?His?Gly?Ala?Glu?Asp?Lys?Tyr?Gly

225 230 235 240

Pro?Leu?Ile?Gly?Lys?Val?Asp?Leu?Met?Lys?Phe?Asn?His?His?His?Asp

245 250 255

Thr?Asn?Lys?Ser?Asn?Thr?Lys?Asp?Phe?Ile?Lys?Asn?Leu?Ser?Pro?Ser

260 265 270

Leu?Ile?Val?Gln?Thr?Ser?Asp?Ser?Leu?Pro?Trp?Lys?Asn?Gly?Val?Asp

275 280 285

Ser?Glu?Tyr?Val?Asn?Trp?Leu?Lys?Glu?Arg?Gly?Ile?Glu?Arg?Ile?Asn

290 295 300

Ala?Ala?Ser?Lys?Asp?Tyr?Asp?Ala?Thr?Val?Phe?Asp?Ile?Arg?Lys?Asp

305 310 315 320

Gly?Phe?Val?Asn?Ile?Ser?Thr?Ser?Tyr?Lys?Pro?Ile?Pro?Ser?Phe?Gln

325 330 335

Ala?Gly?Trp?His?Lys?Ser?Ala?Tyr?Gly?Asn?Trp?Trp?Tyr?Gln?Ala?Pro

340 345 350

Asp?Ser?Thr?Gly?Glu?Tyr?Ala?Val?Gly?Trp?Asn?Glu?Ile?Glu?Gly?Glu

355 360 365

Trp?Tyr?Tyr?Phe?Asn?Gln?Thr?Gly?Ile?Leu?Leu?Gln?Asn?Gln?Trp?Lys

370 375 380

Lys?Trp?Asn?Asn?His?Trp?Phe?Tyr?Leu?Thr?Asp?Ser?Gly?Ala?Ser?Ala

385 390 395 400

Lys?Asn?Trp?Lys?Lys?Ile?Ala?Gly?Ile?Trp?Tyr?Tyr?Phe?Asn?Lys?Glu

405 410 415

Asn?Gln?Met?Glu?Ile?Gly?Trp?Ile?Gln?Asp?Lys?Glu?Gln?Trp?Tyr?Tyr

420 425 430

Leu?Asp?Val?Asp?Gly?Ser?Met?Lys?Thr?Gly?Trp?Leu?Gln?Tyr?Met?Gly

435 440 445

Gln?Trp?Tyr?Tyr?Phe?Ala?Pro?Ser?Gly?Glu?Met?Lys?Met?Gly?Trp?Val

450 455 460

Lys?Asp?Lys?Glu?Thr?Trp?Tyr?Tyr?Met?Asp?Ser?Thr?Gly?Val?Met?Lys

465 470 475 480

Thr?Gly?Glu?Ile?Glu?Val?Ala?Gly?Gln?His?Tyr?Tyr?Leu?Glu?Asp?Ser

485 490 495

Gly?Ala?Met?Lys?Gln?Gly?Trp?His?Lys?Lys?Ala?Asn?Asp?Trp?Tyr?Phe

500 505 510

Tyr?Lys?Thr?Asp?Gly?Ser?Arg?Ala?Val?Gly?Trp?Ile?Lys?Asp?Lys?Asp

515 520 525

Lys?Trp?Tyr?Phe?Leu?Lys?Glu?Asn?Gly?Gln?Leu?Leu?Val?Asn?Gly?Lys

530 535 540

Thr?Pro?Glu?Gly?Tyr?Thr?Val?Asp?Ser?Ser?Gly?Ala?Trp?Leu?Val?Asp

545 550 555 560

Val?Ser?Ile?Glu?Lys?Ser?Ala?Thr?Ile?Lys?Thr?Thr?Ser?His?Ser?Glu

565 570 575

Ile?Lys?Glu?Ser?Lys?Glu?Val?Val?Lys?Lys?Asp?Leu?Glu?Asn?Lys?Glu

580 585 590

Thr?Ser?Gln?His?Glu?Ser?Val?Thr?Asn?Phe?Ser?Thr?Ser?Gln?Asp?Leu

595 600 605

Thr?Ser?Ser?Thr?Ser?Gln?Ser?Ser?Glu?Thr?Ser?Val?Asn?Lys?Ser?Glu

610 615 620

Ser?Glu?Gln

625

<210>192

<211>318

<212>PRT

＜213〉streptococcus pneumoniae

<400>192

Met?Glu?Ile?Asn?Val?Ser?Lys?Leu?Arg?Thr?Asp?Leu?Pro?Gln?Val?Gly

1 5 10 15

Val?Gln?Pro?Tyr?Arg?Gln?Val?His?Ala?His?Ser?Thr?Gly?Asn?Pro?His

20 25 30

Ser?Thr?Val?Gln?Asn?Glu?Ala?Asp?Tyr?His?Trp?Arg?Lys?Asp?Pro?Glu

35 40 45

Leu?Gly?Phe?Phe?Ser?His?Ile?Val?Gly?Asn?Gly?Cys?Ile?Met?Gln?Val

50 55 60

Gly?Pro?Val?Asp?Asn?Gly?Ala?Trp?Asp?Val?Gly?Gly?Gly?Trp?Asn?Ala

65 70 75 80

Glu?Thr?Tyr?Ala?Ala?Val?Glu?Leu?Ile?Glu?Ser?His?Ser?Thr?Lys?Glu

85 90 95

Glu?Phe?Met?Thr?Asp?Tyr?Arg?Leu?Tyr?Ile?Glu?Leu?Leu?Arg?Asn?Leu

100 105 110

Ala?Asp?Glu?Ala?Gly?Leu?Pro?Lys?Thr?Leu?Asp?Thr?Gly?Ser?Leu?Ala

115 120 125

Gly?Ile?Lys?Thr?His?Glu?Tyr?Cys?Thr?Asn?Asn?Gln?Pro?Asn?Asn?His

130 135 140

Ser?Asp?His?Val?Asp?Pro?Tyr?Pro?Tyr?Leu?Ala?Lys?Trp?Gly?Ile?Ser

145 150 155 160

Arg?Glu?Gln?Phe?Lys?His?Asp?Ile?Glu?Asn?Gly?Leu?Thr?Ile?Glu?Thr

165 170 175

Gly?Trp?Gln?Lys?Asn?Asp?Thr?Gly?Tyr?Trp?Tyr?Val?His?Ser?Asp?Gly

180 185 190

Ser?Tyr?Pro?Lys?Asp?Lys?Phe?Glu?Lys?Ile?Asn?Gly?Thr?Trp?Tyr?Tyr

195 200 205

Phe?Asp?Ser?Ser?Gly?Tyr?Met?Leu?Ala?Asp?Arg?Trp?Arg?Lys?His?Thr

210 215 220

Asp?Gly?Asn?Trp?Tyr?Trp?Phe?Asp?Asn?Ser?Gly?Glu?Met?Ala?Thr?Gly

225 230 235 240

Trp?Lys?Lys?Ile?Ala?Asp?Lys?Trp?Tyr?Tyr?Phe?Asn?Glu?Glu?Gly?Ala

245 250 255

Met?Lys?Thr?Gly?Trp?Val?Lys?Tyr?Lys?Asp?Thr?Trp?Tyr?Tyr?Leu?Asp

260 265 270

Ala?Lys?Glu?Gly?Ala?Met?Val?Ser?Asn?Ala?Phe?Ile?Gln?Ser?Ala?Asp

275 280 285

Gly?Thr?Gly?Trp?Tyr?Tyr?Leu?Lys?Pro?Asp?Gly?Thr?Leu?Ala?Asp?Lys

290 295 300

Pro?Glu?Phe?Thr?Val?Glu?Pro?Asp?Gly?Leu?Ile?Thr?Val?Lys

305 310 315

<210>193

<211>513

<212>PRT

＜213〉streptococcus pneumoniae

<400>193

Met?Gly?Thr?Thr?Gly?Phe?ThrIle?Ile?Asp?Leu?Ile?Ile?Leu?Ile?Val

1 5 10 15

Tyr?Leu?Leu?Ala?Val?Leu?Val?Ala?Gly?Ile?Tyr?Phe?Ser?Lys?Lys?Glu

20 25 30

Met?Lys?Gly?Lys?Glu?Phe?Phe?Lys?Gly?Asp?Gly?Ser?Val?Pro?Trp?Tyr

35 40 45

Val?Thr?Ser?Val?Ser?Ile?Phe?Ala?Thr?Met?Leu?Ser?Pro?Ile?Ser?Phe

50 55 60

Leu?Gly?Leu?Ala?Gly?Ser?Ser?Tyr?Ala?Gly?Ser?Trp?Ile?Leu?Trp?Phe

65 70 75 80

Ala?Gln?Leu?Gly?Met?Val?Val?Ala?Ile?Pro?Leu?Thr?Ile?Arg?Phe?Ile

85 90 95

Leu?Pro?Ile?Phe?Ala?Arg?Ile?Asp?Ile?Asp?Thr?Ala?Tyr?Asp?Tyr?Leu

100 105 110

Asp?Lys?Arg?Phe?Asn?Ser?Lys?Ala?Leu?Arg?Ile?Ile?Ser?Ala?Leu?Leu

115 120 125

Phe?Ile?Ile?Tyr?Gln?Leu?Gly?Arg?Met?Ser?Ile?Ile?Met?Tyr?Leu?Pro

130 135 140

Ser?Ala?Gly?Leu?Ser?Val?Leu?Thr?Gly?Ile?Asp?Ile?Asn?Ile?Leu?Ile

145 150 155 160

Ile?Leu?Met?Gly?Val?Val?Ala?Ile?Val?Tyr?Ser?Tyr?Thr?Gly?Gly?Leu

165 170 175

Lys?Ser?Val?Leu?Trp?Thr?Asp?Phe?Ile?Gln?Gly?Val?Ile?Leu?Ile?Ser

180 185 190

Gly?Val?Val?Leu?Ala?Leu?Phe?Val?Leu?Ile?Ala?Asn?Ile?Lys?Gly?Gly

195 200 205

Phe?Gly?Ala?Val?Ala?GIu?Thr?Leu?Ala?Asn?Gly?Lys?Phe?Leu?Ala?Ala

210 215 220

Asn?Glu?Lys?Leu?Phe?Asp?Pro?Asn?Leu?Leu?Ser?Asn?Ser?Ile?Phe?Leu

225 230 235 240

Ile?Val?Met?Gly?Ser?Gly?Phe?Thr?Ile?Leu?Ser?Ser?Tyr?Ala?Ser?Ser

245 250 255

Gln?Asp?Leu?Val?Gln?Arg?Phe?Thr?Thr?Thr?Gln?Asn?Ile?Lys?Lys?Leu

260 265 270

Asn?Lys?Met?Leu?Phe?Thr?Asn?Gly?Val?Leu?Ser?Leu?Ala?Thr?Ala?Thr

275 280 285

Val?Phe?Tyr?Leu?Ile?Gly?Thr?Gly?Leu?Tyr?Val?Phe?Tyr?Gln?Val?Gln

290 295 300

Asn?Ala?Asp?Ser?Ala?Ala?Ser?Asn?Ile?Pro?Gln?Asp?Gln?Ile?Phe?Met

305 310 315 320

Tyr?Phe?Ile?Ala?Tyr?Gln?Leu?Pro?Val?Gly?Ile?Thr?Gly?Leu?Ile?Leu

325 330 335

Ala?Ala?Ile?Tyr?Ala?Ala?Ser?Gln?Ser?Thr?Ile?Ser?Thr?Gly?Leu?Asn

340 345 350

Ser?Val?Ala?Thr?Ser?Trp?Thr?Leu?Asp?Ile?Gln?Asp?Val?Ile?Ser?Lys

355 360 365

Asn?Met?Ser?Asp?Asn?Arg?Arg?Thr?Lys?Ile?Ala?Gln?Phe?Val?Ser?Leu

370 375 380

Ala?Val?Gly?Leu?Phe?Ser?Ile?Gly?Val?Ser?Ile?Val?Met?Ala?His?Ser

385 390 395 400

Asp?Ile?Lys?Ser?Ala?Tyr?Glu?Trp?Phe?Asn?Ser?Phe?Met?Gly?Leu?Val

405 410 415

Leu?Gly?Leu?Leu?Gly?Gly?Val?Phe?Ile?Leu?Gly?Phe?Val?Ser?Lys?Lys

420 425 430

Ala?Asn?Lys?Gln?Gly?Ala?Tyr?Ala?Ala?Leu?Ile?Val?Ser?Thr?Ile?Val

435 440 445

Met?Val?Phe?Ile?Lys?Tyr?Phe?Leu?Pro?Pro?Thr?Ala?Val?Ser?Tyr?Trp

450 455 460

Ala?Tyr?Ser?Leu?Ile?Ser?Ile?Ser?Val?Ser?Val?Val?Ser?Gly?Tyr?Ile

465 470 475 480

Val?Ser?Val?Leu?Thr?Gly?Asn?Lys?Val?Ser?Ala?Pro?Lys?Tyr?Thr?Thr

485 490 495

Ile?His?Asp?Ile?Thr?Glu?Ile?Lys?Ala?Asp?Ser?Ser?Trp?Glu?Val?Arg

500 505 510

His

<210>194

<211>826

<212>PRT

＜213〉streptococcus pneumoniae

<400>194

Met?Lys?Ile?Asn?Lys?Lys?Tyr?Leu?Ala?Gly?Ser?Val?Ala?Val?Leu?Ala

1 5 10 15

Leu?Ser?Val?Cys?Ser?Tyr?Glu?Leu?Gly?Arg?His?Gln?Ala?Gly?Gln?Asp

20 25 30

Lys?Lys?Glu?Ser?Asn?Arg?Val?Ala?Tyr?Ile?Asp?Gly?Asp?Gln?Ala?Gly

35 40 45

Gln?Lys?Ala?Glu?Asn?Leu?Thr?Pro?Asp?Glu?Val?Ser?Lys?Arg?Glu?Gly

50 55 60

Ile?Asn?Ala?Glu?Gln?Ile?Val?Ile?Lys?Ile?Thr?Asp?Gln?Gly?Tyr?Val

65 70 75 80

Thr?Ser?His?Gly?Asp?His?Tyr?His?Tyr?Tyr?Asn?Gly?Lys?Val?Pro?Tyr

85 90 95

Asp?Ala?Ile?Ile?Ser?Glu?Glu?Leu?Leu?Met?Lys?Asp?Pro?Asn?Tyr?Gln

100 105 110

Leu?Lys?Asp?Ser?Asp?Ile?Val?Asn?Glu?Ile?Lys?Gly?Gly?Tyr?Val?Ile

115 120 125

Lys?Val?Asp?Gly?Lys?Tyr?Tyr?Val?Tyr?Leu?Lys?Asp?Ala?Ala?His?Ala

130 135 140

Asp?Asn?Ile?Arg?Thr?Lys?Glu?Glu?Ile?Lys?Arg?Gln?Lys?Gln?Glu?Arg

145 150 155 160

Ser?His?Asn?His?Gly?Ser?Gly?Ala?Asn?Asp?His?Ala?Val?Ala?Ala?Ala

165 170 175

Arg?Ala?Gln?Gly?Arg?Tyr?Thr?Thr?Asp?Asp?Gly?Tyr?Ile?Phe?Asn?Ala

180 185 190

Ser?Asp?Ile?Ile?Glu?Asp?Thr?Gly?Asp?Ala?Tyr?Ile?Val?Pro?His?Gly

195 200 205

Asp?His?Tyr?His?Tyr?Ile?Pro?Lys?Asn?Glu?Leu?Ser?Ala?Ser?Glu?Leu

210 215 220

Ala?Ala?Ala?Glu?Ala?Tyr?Trp?Asn?Gly?Lys?Gln?Gly?Ser?Arg?Pro?Ser

225 230 235 240

Ser?Ser?Ser?Ser?Tyr?Asn?Ala?Asn?Pro?Ala?Gln?Pro?Arg?Leu?Ser?Glu

245 250 255

Asn?His?Asn?Leu?Thr?Val?Thr?Pro?Thr?Tyr?His?Gln?Asn?Gln?Gly?Glu

260 265 270

Asn?Ile?Ser?Ser?Leu?Leu?Arg?Glu?Leu?Tyr?Ala?Lys?Pro?Leu?Ser?Glu

275 280 285

Arg?His?Val?Glu?Ser?Asp?Gly?Leu?Ile?Phe?Asp?Pro?Ala?Gln?Ile?Thr

290 295 300

Ser?Arg?Thr?Ala?Arg?Gly?Val?Ala?Val?Pro?His?Gly?Asn?His?Tyr?His

305 310 315 320

PheIle?Pro?Tyr?Glu?Gln?Met?Ser?Glu?Leu?Glu?Lys?Arg?Ile?Ala?Arg

325 330 335

IleIle?Pro?Leu?Arg?Tyr?Arg?Ser?Asn?His?Trp?Val?Pro?Asp?Ser?Arg

340 345 350

Pro?Glu?Gln?Pro?Ser?Pro?Gln?Ser?Thr?Pro?Glu?Pro?Ser?Pro?Ser?Pro

355 360 365

Gln?Pro?Ala?Pro?Asn?Pro?Gln?Pro?Ala?Pro?Ser?Asn?Pro?Ile?Asp?Glu

370 375 380

Lys?Leu?Val?Lys?Glu?Ala?Val?Arg?Lys?Val?Gly?Asp?Gly?Tyr?Val?Phe

385 390 395 400

Glu?Glu?Asn?Gly?Val?Ser?Arg?Tyr?Ile?Pro?Ala?Lys?Asp?Leu?Ser?Ala

405 410 415

Glu?Thr?Ala?Ala?Gly?Ile?Asp?Ser?Lys?Leu?Ala?Lys?Gln?Glu?Ser?Leu

420 425 430

Ser?His?Lys?Leu?Gly?Ala?Lys?Lys?Thr?Asp?Leu?Pro?Ser?Ser?Asp?Arg

435 440 445

Glu?Phe?Tyr?Asn?Lys?Ala?Tyr?Asp?Leu?Leu?Ala?Arg?Ile?His?Gln?Asp

450 455 460

Leu?Leu?Asp?Asn?Lys?Gly?Arg?Gln?Val?Asp?Phe?Glu?Ala?Leu?Asp?Asn

465 470 475 480

Leu?Leu?Glu?Arg?Leu?Lys?Asp?Val?Pro?Ser?Asp?Lys?Val?Lys?Leu?Val

485 490 495

Asp?Asp?Ile?Leu?Ala?Phe?Leu?Ala?Pro?Ile?Arg?His?Pro?Glu?Arg?Leu

500 505 510

Gly?Lys?Pro?Asn?Ala?Gln?Ile?Thr?Tyr?Thr?Asp?Asp?Glu?Ile?Gln?Val

515 520 525

Ala?Lys?Leu?Ala?Gly?Lys?Tyr?Thr?Thr?Glu?Asp?Gly?Tyr?Ile?Phe?Asp

530 535 540

Pro?Arg?Asp?Ile?Thr?Ser?Asp?Glu?Gly?Asp?Ala?Tyr?Val?Thr?Pro?His

545 550 555 560

Met?Thr?His?Ser?His?Trp?Ile?Lys?Lys?Asp?Ser?Leu?Ser?Glu?Ala?Glu

565 570 575

Arg?Ala?Ala?Ala?Gln?Ala?Tyr?Ala?Lys?Glu?Lys?Gly?Leu?Thr?Pro?Pro

580 585 590

Ser?Thr?Asp?His?Gln?Asp?Ser?Gly?Asn?Thr?Glu?Ala?Lys?Gly?Ala?Glu

595 600 605

Ala?Ile?Tyr?Asn?Arg?Val?Lys?Ala?Ala?Lys?Lys?Val?Pro?Leu?Asp?Arg

610 615 620

Met?Pro?Tyr?Asn?Leu?Gln?Tyr?Thr?Val?Glu?Val?Lys?Asn?Gly?Ser?Leu

625 630 635 640

Ile?Ile?Pro?His?Tyr?Asp?His?Tyr?His?Asn?Ile?Lys?Phe?Glu?Trp?Phe

645 650 655

Asp?Glu?Gly?Leu?Tyr?Glu?Ala?Pro?Lys?Gly?Tyr?Thr?Leu?Glu?Asp?Leu

660 665 670

Leu?Ala?Thr?Val?Lys?Tyr?Tyr?Val?Glu?His?Pro?Asn?Glu?Arg?Pro?His

675 680 685

Ser?Asp?Asn?Gly?Phe?Gly?Asn?Ala?Ser?Asp?His?Val?Gln?Arg?Asn?Lys

690 695 700

Asn?Gly?Gln?Ala?Asp?Thr?Asn?Gln?Thr?Glu?Lys?Pro?Ser?Glu?Glu?Lys

705 710 715 720

Pro?Gln?Thr?Glu?Lys?Pro?Glu?Glu?Glu?Thr?Pro?Arg?Glu?Glu?Lys?Pro

725 730 735

Gln?Ser?Glu?Lys?Pro?Glu?Ser?Pro?Lys?Pro?Thr?Glu?Glu?Pro?Glu?Glu

740 745 750

Ser?Pro?Glu?Glu?Ser?Glu?Glu?Pro?Gln?Val?Glu?Thr?Glu?Lys?Val?Glu

755 760 765

Glu?Lys?Leu?Arg?Glu?Ala?Glu?Asp?Leu?Leu?Gly?Lys?Ile?Gln?Asp?Pro

770 775 780

Ile?Ile?Lys?Ser?Asn?Ala?Lys?Glu?Thr?Leu?Thr?Gly?Leu?Lys?Asn?Asn

785 790 795 800

Leu?Leu?Phe?Gly?Thr?Gln?Asp?Asn?Asn?Thr?Ile?Met?Ala?Glu?Ala?Glu

805 810 815

Lys?Leu?Leu?Ala?Leu?Leu?Lys?Glu?Ser?Lys

820 825

<210>195

<211>295

<212>PRT

＜213〉streptococcus pneumoniae

<400>195

Met?Glu?Gly?Leu?Val?Arg?Val?His?Leu?Leu?Pro?Val?Phe?Gly?Asp?Tyr

1 5 10 15

Lys?Leu?Ser?Lys?Leu?Thr?Thr?Pro?Ile?Leu?Gln?Gln?Gln?Val?Asn?Lys

20 25 30

Trp?Ala?Asp?Lys?Ala?Asn?Lys?Gly?Glu?Lys?Gly?Ala?Phe?Ala?Asn?Tyr

35 40 45

Ser?Leu?Leu?His?Asn?Met?Asn?Lys?Arg?Ile?Leu?Lys?Tyr?Gly?Val?Ala

50 55 60

Ile?Gln?Val?Ile?Gln?Tyr?Asn?Pro?Ala?Asn?Asp?Val?Ile?Val?Pro?Arg

65 70 75 80

Lys?Gln?Gln?Lys?Glu?Lys?Ala?Ala?Val?Lys?Tyr?Leu?Asp?Asn?Lys?Glu

85 90 95

Leu?Lys?Gln?Phe?Leu?Asp?Tyr?Leu?Asp?Ala?Leu?Asp?Gln?Ser?Asn?Tyr

100 105 110

Glu?Asn?Leu?Phe?Asp?Val?Val?Leu?Tyr?Lys?Thr?Leu?Leu?Ala?Thr?Gly

115 120 125

Cys?Arg?Ile?Ser?Glu?Ala?Leu?Ala?Leu?Glu?Trp?Ser?Asp?Ile?Asp?Leu

130 135 140

Glu?Ser?Gly?Val?Ile?Ser?Ile?Asn?Lys?Thr?Leu?Asn?Arg?Tyr?Gln?Glu

145 150 155 160

Ile?Asn?Ser?Pro?Lys?Ser?Ser?Ala?Gly?Tyr?Arg?Asp?Ile?Pro?Ile?Asp

165 170 175

Lys?Ala?Thr?Leu?Leu?Leu?Leu?Lys?Gln?Tyr?Lys?Asn?Arg?Gln?Gln?Ile

180 185 190

Gln?Ser?Trp?Lys?Leu?Gly?Arg?Ser?Glu?Thr?Val?Val?Phe?Ser?Val?Phe

195 200 205

Thr?Glu?Lys?Tyr?Ala?Tyr?Ala?Cys?Asn?Leu?Arg?Lys?Arg?Leu?Asn?Lys

210 215 220

His?Phe?Asp?Ala?Ala?Gly?Val?Thr?Asn?Val?Ser?Phe?His?Gly?Phe?Arg

225 230 235 240

His?Thr?His?Thr?Thr?Met?Met?Leu?Tyr?Ala?Gln?Val?Ser?Pro?Lys?Asp

245 250 255

Val?Gln?Tyr?Arg?Leu?Gly?His?Ser?Asn?Leu?Met?Ile?Thr?Glu?Asn?Thr

260 265 270

Tyr?Trp?His?Thr?Asn?Gln?Glu?Asn?Ala?Lys?Lys?Ala?Val?Ser?Asn?Tyr

275 280 285

Glu?Thr?Ala?Ile?Asn?Asn?Leu

290 295

<210>196

<211>2235

<212>DNA

＜213〉streptococcus pneumoniae

<400>196

atgaataaga?aaaaaatgat?tttaacaagt?ctagccagcg?tcgctatctt?aggggctggt?60

tttgttacgt?ctcagcctac?ttttgtaaga?gcagaagaat?ctccacaagt?tgtcgaaaaa?120

tcttcattag?agaagaaata?tgaggaagca?aaagcaaaag?ctgatactgc?caagaaagat?180

tacgaaacgg?ctaaaaagaa?agcagaagac?gctcagaaaa?agtatgaaga?tgatcagaag?240

agaactgagg?agaaagctcg?aaaagaagca?gaagcatctc?aaaaattgaa?tgatgtggcg?300

cttgttgttc?aaaatgcata?taaagagtac?cgagaagttc?aaaatcaacg?tagtaaatat?360

aaatctgacg?ctgaatatca?gaaaaaatta?acagaggtcg?actctaaaat?agagaaggct?420

aggaaagagc?aacaggactt?gcaaaataaa?tttaatgaag?taagagcagt?tgtagttcct?480

gaaccaaatg?cgttggctga?gactaagaaa?aaagcagaag?aagctaaagc?agaagaaaaa?540

gtagctaaga?gaaaatatga?ttatgcaact?ctaaaggtag?cactagcgaa?gaaagaagta?600

gaggctaagg?aacttgaaat?tgaaaaactt?caatatgaaa?tttctacttt?ggaacaagaa?660

gttgctactg?ctcaacatca?agtagataat?ttgaaaaaac?ttcttgctgg?tgcggatcct?720

gatgatggca?cagaagttat?agaagctaaa?ttaaaaaaag?gagaagctga?gctaaacgct?780

aaacaagctg?agttagcaaa?aaaacaaaca?gaacttgaaa?aacttcttga?cagccttgat?840

cctgaaggta?agactcagga?tgaattagat?aaagaagcag?aagaagctga?gttggataaa?900

aaagctgatg?aacttcaaaa?taaagttgct?gatttagaaa?aagaaattag?taaccttgaa?960

atattacttg?gaggggctga?tcctgaagat?gatactgctg?ctcttcaaaa?taaattagct?1020

gctaaaaaag?ctgagttagc?aaaaaaacaa?acagaacttg?aaaaacttct?tgacagcctt?1080

gatcctgaag?gtaagactca?ggatgaatta?gataaagaag?cagaagaagc?tgagttggat?1140

aaaaaagctg?atgaacttca?aaataaagtt?gctgatttag?aaaaagaaat?tagtaacctt?1200

gaaatattac?ttggaggggc?tgattctgaa?gatgatactg?ctgctcttca?aaataaatta?1260

gctactaaaa?aagctgaatt?ggaaaaaact?caaaaagaat?tagatgcagc?tcttaatgag?1320

ttaggccctg?atggagatga?agaagaaact?ccagcgccgg?ctcctcaacc?agagcaacca?1380

gctcctgcac?caaaaccaga?gcaaccagct?ccagctccaa?aaccagagca?accagctcct?1440

gcaccaaaac?cagagcaacc?agctccagct?ccaaaaccag?agcaaccagc?tccagctcca?1500

aaaccagagc?aaccagctaa?gccggagaaa?ccagctgaag?agcctactca?accagaaaaa?1560

ccagccactc?caaaaacagg?ctggaaacaa?gaaaacggta?tgtggtattt?ctacaatact?1620

gatggttcaa?tggcaatagg?ttggctccaa?aacaacggtt?catggtacta?cctaaacgct?1680

aacggcgcta?tggcaacagg?ttgggtgaaa?gatggagata?cctggtacta?tcttgaagca?1740

tcaggtgcta?tgaaagcaag?ccaatggttc?aaagtatcag?ataaatggta?ctatgtcaac?1800

agcaatggcg?ctatggcgac?aggctggctc?caatacaatg?gctcatggta?ctacctcaac?1860

gctaatggtg?atatggcgac?aggatggctc?caatacaacg?gttcatggta?ttacctcaac?1920

gctaatggtg?atatggcgac?aggatgggct?aaagtcaacg?gttcatggta?ctacctaaac?1980

gctaacggtg?ctatggctac?aggttgggct?aaagtcaacg?gttcatggta?ctacctaaac?2040

gctaacggtt?caatggcaac?aggttgggtg?aaagatggag?atacctggta?ctatcttgaa?2100

gcatcaggtg?ctatgaaagc?aagccaatgg?ttcaaagtat?cagataaatg?gtactatgtc?2160

aatggcttag?gtgcccttgc?agtcaacaca?actgtagatg?gctataaagt?caatgccaat?2220

ggtgaatggg?tttaa 2235

<210>197

<211>2082

<212>DNA

＜213〉streptococcus pneumoniae

<400>197

atgtttgcat?caaaaagcga?aagaaaagta?cattattcaa?ttcgtaaatt?tagtgttgga?60

gtagctagtg?tagttgttgc?cagtcttgtt?atgggaagtg?tggttcatgc?gacagagaac?120

gagggagcta?cccaagtacc?cacttcttct?aatagggcaa?atgaaagtca?ggcagaacaa?180

ggagaacaac?ctaaaaaact?cgattcagaa?cgagataagg?caaggaaaga?ggtcgaggaa?240

tatgtaaaaa?aaatagtggg?tgagagctat?gcaaaatcaa?ctaaaaagcg?acatacaatt?300

actgtagctc?tagttaacga?gttgaacaac?attaagaacg?agtatttgaa?taaaatagtt?360

gaatcaacct?cagaaagcca?actacagata?ctgatgatgg?agagtcgatc?aaaagtagat?420

gaagctgtgt?ctaagtttga?aaaggactca?tcttcttcgt?caagttcaga?ctcttccact?480

aaaccggaag?cttcagatac?agcgaagcca?aacaagccga?cagaaccagg?agaaaaggta?540

gcagaagcta?agaagaaggt?tgaagaagct?gagaaaaaag?ccaaggatca?aaaagaagaa?600

gatcgtcgta?actacccaac?cattacttac?aaaacgcttg?aacttgaaat?tgctgagtcc?660

gatgtggaag?ttaaaaaagc?ggagcttgaa?ctagtaaaag?tgaaagctaa?cgaacctcga?720

gacgagcaaa?aaattaagca?agcagaagcg?gaagttgaga?gtaaacaagc?tgaggctaca?780

aggttaaaaa?aaatcaagac?agatcgtgaa?gaagcagaag?aagaagctaa?acgaagagca?840

gatgctaaag?agcaaggtaa?accaaagggg?cgggcaaaac?gaggagttcc?tggagagcta?900

gcaacacctg?ataaaaaaga?aaatgatgcg?aagtcttcag?attctagcgt?aggtgaagaa?960

actcttccaa?gcccatccct?gaaaccagaa?aaaaaggtag?cagaagctga?gaagaaggtt?1020

gaagaagcta?agaaaaaagc?cgaggatcaa?aaagaagaag?atcgccgtaa?ctacccaacc?1080

aatacttaca?aaacgcttga?acttgaaatt?gctgagtccg?atgtggaagt?taaaaaagcg?1140

gagcttgaac?tagtaaaaga?ggaagctaag?gaacctcgaa?acgaggaaaa?agttaagcaa?1200

gcaaaagcgg?aagttgagag?taaaaaagct?gaggctacaa?ggttagaaaa?aatcaagaca?1260

gatcgtaaaa?aagcagaaga?agaagctaaa?cgaaaagcag?cagaagaaga?taaagttaaa?1320

gaaaaaccag?ctgaacaacc?acaaccagcg?ccggctccaa?aagcagaaaa?accagctcca?1380

gctccaaaac?cagagaatcc?agctgaacaa?ccaaaagcag?aaaaaccagc?tgatcaacaa?1440

gctgaagaag?actatgctcg?tagatcagaa?gaagaatata?atcgcttgac?tcaacagcaa?1500

ccgccaaaaa?ctgaaaaacc?agcacaacca?tctactccaa?aaacaggctg?gaaacaagaa?1560

aacggtatgt?ggtacttcta?caatactgat?ggttcaatgg?cgacaggatg?gctccaaaac?1620

aatggctcat?ggtactacct?caacagcaat?ggcgctatgg?cgacaggatg?gctccaaaac?1680

aatggttcat?ggtactatct?aaacgctaat?ggttcaatgg?caacaggatg?gctccaaaac?1740

aatggttcat?ggtactacct?aaacgctaat?ggttcaatgg?cgacaggatg?gctccaatac?1800

aatggctcat?ggtactacct?aaacgctaat?ggttcaatgg?cgacaggatg?gctccaatac?1860

aatggctcat?ggtactacct?aaacgctaat?ggtgatatgg?cgacaggttg?ggtgaaagat?1920

ggagatacct?ggtactatct?tgaagcatca?ggtgctatga?aagcaagcca?atggttcaaa?1980

gtatcagata?aatggtacta?tgtcaatggc?tcaggtgccc?ttgcagtcaa?cacaactgta?2040

gatggctatg?gagtcaatgc?caatggtgaa?tgggtaaact?aa 2082

<210>198

<211>390

<212>DNA

＜213〉streptococcus pneumoniae

<400>198

atggtaaaaa?gacgtataag?gagagggacg?agagaacctg?aaaaagttgt?tgttcctgag?60

caatcatcta?ttccttcgta?tcctgtatct?gttacatcta?accaaggaac?agatgtagca?120

gtagaaccag?ctaaagcagt?tgctccaaca?acagactgga?aacaagaaaa?tggtatgtgg?180

tatttttata?atactgatgg?ttccatggca?acaggttggg?tacaagttaa?tagttcatgg?240

tactacctca?acagcaacgg?ttctatgaaa?gtcaatcaat?ggttccaagt?tggtggtaaa?300

tggtattatg?taaatacatc?gggtgagtta?gcggtcaata?caagtataga?tggctataga?360

gtcaatgata?atggtgaatg?ggtgcgttaa 390

<210>199

<211>693

<212>DNA

＜213〉streptococcus pneumoniae

<400>199

ctgaatacaa?gttttgttca?tgctgctgat?gggattcaat?atgtcagaga?tgatactaga?60

gataaagaag?agggaataga?gtatgatgac?gctgacaatg?gggatattat?tgtaaaagta?120

gcgactaaac?ctaaggtagt?aaccaagaaa?atttcaagta?cgcgaattcg?ttatgaaaaa?180

gatgaaacaa?aagaccgtag?tgaaaatcct?gttacaattg?atggagagga?tggctatgta?240

actacgacaa?ggacctacga?tgttaatcca?gagactggtt?atgttaccga?acaggttact?300

gttgatagaa?aagaagccac?ggatacagtt?atcaaagttc?cagctaaaag?caaggttgaa?360

gaagttcttg?ttccatttgc?tactaaatat?gaagcagaca?atgacctttc?tgcaggacag?420

gagcaagaga?ttactctagg?aaagaatggg?aaaacagtta?caacgataac?ttataatgta?480

gatggaaaga?gtggacaagt?aactgagagt?actttaagtc?aaaaaaaaga?ctctcaaaca?540

agagttgtta?aaaaaagaac?caagccccaa?gttcttgtcc?aagaaattcc?aatcgaaaca?600

gaatatctcg?atggcccaac?tcttgataaa?agtcaagaag?tagaagaagt?aggagaaatt?660

ggtaaattac?tcttactaca?atctatactg?tag 693

<210>200

<211>1023

<212>DNA

＜213〉streptococcus pneumoniae

<400>200

atgaagcttt?tgaaaaaaat?gatgcaaatc?gcactagcca?catttttctt?cggtttgtta?60

gcgacaaata?cagtatttgc?agatgattct?gaaggatggc?agtttgtcca?agaaaatggt?120

agaacctact?acaaaaaggg?ggatctaaaa?gaaacctact?ggagagtgat?agatgggaag?180

tactattatt?ttgatccttt?atccggagag?atggttgtcg?gctggcaata?tatacctgct?240

ccacacaagg?gggttacgat?tggtccttct?ccaagaatag?agattgctct?tagaccagat?300

tggttttatt?ttggtcaaga?tggtgtatta?caagaatttg?ttggcaagca?agttttagaa?360

gcaaaaactg?ctacgaatac?caacaaacat?catggggaag?aatatgatag?ccaagcagag?420

aaacgagtct?attattttga?agatcagcgt?agttatcata?ctttaaaaac?tggttggatt?480

tatgaagagg?gtcattggta?ttatttacag?aaggatggtg?gctttgattc?gcgcatcaac?540

agattgacgg?ttggagagct?agcacgtggt?tgggttaagg?attaccctct?tacgtatgat?600

gaagagaagc?taaaagcagc?tccatggtac?tatctaaatc?cagcaactgg?cattatgcaa?660

acaggttggc?aatatctagg?taatagatgg?tactacctcc?attcgtcagg?agctatggca?720

actggctggt?ataaggaagg?ctcaacttgg?tactatctag?atgctgaaaa?tggtgatatg?780

agaactggct?ggcaaaacct?tgggaacaaa?tggtactatc?tccgttcatc?aggagctatg?840

gcaactggtt?ggtatcagga?aagttcgact?tggtactatc?taaatgcaag?taatggagat?900

atgaaaacag?gctggttcca?agtcaatggt?aactggtact?atgcctatga?ttcaggtgct?960

ttagctgtta?ataccacagt?aggtggttac?tacttaaact?ataatggtga?atgggttaag?1020

taa 1023

<210>201

<211>546

<212>DNA

＜213〉streptococcus pneumoniae

<400>201

ttggctggta?gatatggttc?tgctgttcag?tgtacagaag?tgactgcctc?aaacctttca?60

acagttaaaa?ctaaagctac?ggttgtagaa?aaaccactga?aagattttag?agcgtctacg?120

tctgatcagt?ctggttgggt?ggaatctaat?ggtaaatggt?atttctatga?gtctggtgat?180

gtgaagacag?gttgggtgaa?aacagatggt?aaatggtact?atttgaatga?cttaggtgtc?240

atgcagactg?gatttgtaaa?attttctggt?agctggtatt?acttgagcaa?ttcaggtgct?300

atgtttacag?gctggggaac?agatggtagc?agatggttct?actttgacgg?ctcaggagct?360

atgaagacag?gctggtacaa?ggaaaatggc?acttggtatt?accttgacga?agcaggtatc?420

atgaagacag?gttggtttaa?agtcggacca?cactggtact?atgcctacgg?ttcaggagct?480

ttggctgtga?gcacaacaac?accagatggt?taccgtgtaa?atggtaatgg?tgaatgggta?540

aactag 546

<210>202

<211>999

<212>DNA

＜213〉streptococcus pneumoniae

<400>202

atgaaaattt?tgaaaaaaac?tatgcaagtt?ggactgacag?tatttttctt?tggtttgcta?60

gggaccagta?cagtatttgc?agatgattct?gaaggatggc?agtttgtcca?agaaaacgga?120

agaacctact?acaaaaaggg?ggacctcaaa?gaaacctact?ggcgagtgat?tgatggtaag?180

tactattatt?ttgattctct?atctggagag?atggttgtcg?gctggcaata?tatcccgttt?240

ccatctaaag?gtagtacaat?tggtccttac?ccaaatggta?tcagattaga?aggttttcca?300

aagtcagagt?ggtactactt?cgataaaaat?ggagtgctac?aagagtttgt?tggttggaaa?360

acattagaga?ttaaaactaa?agacagtgtt?ggaagaaagt?acggggaaaa?acgtgaagat?420

tcagaagata?aagaagagaa?gcgttattat?acgaactatt?actttaatca?aaatcattct?480

ttagagacag?gttggcttta?tgatcagtct?aactggtatt?atctagctaa?gacggaaatt?540

aatggagaaa?actaccttgg?tggtgaaaga?cgtgcggggt?ggataaacga?tgattcgact?600

tggtactacc?tagatccaac?aactggtatt?atgcaaacag?gttggcaata?tctaggtaat?660

aagtggtact?acctccgttc?ctcaggagca?atggccactg?gctggtatca?ggaaggtacc?720

acttggtatt?atttagacca?cccaaatggc?gatatgaaaa?caggttggca?aaaccttggg?780

aacaaatggt?actatctccg?ttcatcagga?gctatggcaa?ctggttggta?tcaagatggt?840

tcaacttggt?actacctaaa?tgcaggtaat?ggagacatga?agacaggttg?gttccaggtc?900

aatggcaact?ggtactatgc?ttatagctca?ggtgctttgg?cagtgaatac?gaccgtagat?960

ggctattctg?tcaactataa?tggcgaatgg?gttcggtaa 999

<210>203

<211>1884

<212>DNA

＜213〉streptococcus pneumoniae

<400>203

atgaaaaaga?aattaactag?tttagcactt?gtaggcgctt?ttttaggttt?gtcatggtat?60

gggaatgttc?aggctcaaga?aagttcagga?aataaaatcc?actttatcaa?tgttcaagaa?120

ggtggcagtg?atgcgattat?tcttgaaagc?aatggacatt?ttgccatggt?ggatacagga?180

gaagattatg?atttcccaga?tggaagtgat?tctcgctatc?catggagaga?aggaattgaa?240

acgtcttata?agcatgttct?aacagaccgt?gtctttcgtc?gtttgaagga?attgggtgtc?300

caaaaacttg?attttatttt?ggtgacccat?acccacagtg?atcatattgg?aaatgttgat?360

gaattactgt?ctacctatcc?agttgaccga?gtctatctta?agaaatatag?tgatagtcgt?420

attactaatt?ctgaacgtct?atgggataat?ctgtatggct?atgataaggt?tttacagact?480

gctgcagaaa?aaggtgtttc?agttattcaa?aatatcacac?aaggggatgc?tcattttcag?540

tttggggaca?tggatattca?gctctataat?tatgaaaatg?aaactgattc?atcgggtgaa?600

ttaaagaaaa?tttgggatga?caattccaat?tccttgatta?gcgtggtgaa?agtcaatggc?660

aagaaaattt?accttggggg?cgatttagat?aatgttcatg?gagcagaaga?caagtatggt?720

cctctcattg?gaaaagttga?tttgatgaag?tttaatcatc?accatgatac?caacaaatca?780

aataccaagg?atttcattaa?aaatttgagt?ccgagtttga?ttgttcaaac?ttcggatagt?840

ctaccttgga?aaaatggtgt?tgatagtgag?tatgttaatt?ggctcaaaga?acgaggaatt?900

gagagaatca?acgcagccag?caaagactat?gatgcaacag?tttttgatat?tcgaaaagac?960

ggttttgtca?atatttcaac?atcctacaag?ccgattccaa?gttttcaagc?tggttggcat?1020

aagagtgcat?atgggaactg?gtggtatcaa?gcgcctgatt?ctacaggaga?gtatgctgtc?1080

ggttggaatg?aaatcgaagg?tgaatggtat?tactttaacc?aaacgggtat?cttgttacag?1140

aatcaatgga?aaaaatggaa?caatcattgg?ttctatttga?cagactctgg?tgcttctgct?1200

aaaaattgga?agaaaatcgc?tggaatctgg?tattatttta?acaaagaaaa?ccagatggaa?1260

attggttgga?ttcaagataa?agagcagtgg?tattatttgg?atgttgatgg?ttctatgaag?1320

acaggatggc?ttcaatatat?ggggcaatgg?tattactttg?ctccatcagg?ggaaatgaaa?1380

atgggctggg?taaaagataa?agaaacctgg?tactatatgg?attctactgg?tgtcatgaag?1440

acaggtgaga?tagaagttgc?tggtcaacat?tattatctgg?aagattcagg?agctatgaag?1500

caaggctggc?ataaaaaggc?aaatgattgg?tatttctaca?agacagacgg?ttcacgagct?1560

gtgggttgga?tcaaggacaa?ggataaatgg?tacttcttga?aagaaaatgg?tcaattactt?1620

gtgaacggta?agacaccaga?aggttatact?gtggattcaa?gtggtgcctg?gttagtggat?1680

gtttcgatcg?agaaatctgc?tacaattaaa?actacaagtc?attcagaaat?aaaagaatcc?1740

aaagaagtag?tgaaaaagga?tcttgaaaat?aaagaaacga?gtcaacatga?aagtgttaca?1800

aatttttcaa?ctagtcaaga?tttgacatcc?tcaacttcac?aaagctctga?aacgagtgta?1860

aacaaatcgg?aatcagaaca?gtag 1884

<210>204

<211>957

<212>DNA

＜213〉streptococcus pneumoniae

<400>204

atggaaatta?atgtgagtaa?attaagaaca?gatttgcctc?aagtcggcgt?gcaaccatat?60

aggcaagtac?acgcacactc?aactgggaat?ccgcattcaa?ccgtacagaa?tgaagcggat?120

tatcactggc?ggaaagaccc?agaattaggt?tttttctcgc?acattgttgg?gaacggttgc?180

atcatgcagg?taggacctgt?tgataatggt?gcctgggacg?ttgggggcgg?ttggaatgct?240

gagacctatg?cagcggttga?actgattgaa?agccattcaa?ccaaagaaga?gttcatgacg?300

gactaccgcc?tttatatcga?actcttacgc?aatctagcag?atgaagcagg?tttgccgaaa?360

acgcttgata?cagggagttt?agctggaatt?aaaacgcacg?agtattgcac?gaataaccaa?420

ccaaacaacc?actcagacca?cgttgaccct?tatccatatc?ttgctaaatg?gggcattagc?480

cgtgagcagt?ttaagcatga?tattgagaac?ggcttgacga?ttgaaacagg?ctggcagaag?540

aatgacactg?gctactggta?cgtacattca?gacggctctt?atccaaaaga?caagtttgag?600

aaaatcaatg?gcacttggta?ctactttgac?agttcaggct?atatgcttgc?agaccgctgg?660

aggaagcaca?cagacggcaa?ctggtactgg?ttcgacaact?caggcgaaat?ggctacaggc?720

tggaagaaaa?tcgctgataa?gtggtactat?ttcaacgaag?aaggtgccat?gaagacaggc?780

tgggtcaagt?acaaggacac?ttggtactac?ttagacgcta?aagaaggcgc?catggtatca?840

aatgccttta?tccagtcagc?ggacggaaca?ggctggtact?acctcaaacc?agacggaaca?900

ctggcagaca?agccagaatt?cacagtagag?ccagatggct?tgattacagt?aaaataa 957

<210>205

<211>1542

<212>DNA

＜213〉streptococcus pneumoniae

<400>205

atgggcacaa?caggatttac?aataattgac?ttaattatct?tgattgttta?tttacttgcg?60

gtgttggttg?caggtatcta?tttctctaaa?aaagagatga?aaggaaaaga?gttctttaaa?120

ggagatggtt?cggttccttg?gtatgttact?tcggtatcca?tttttgccac?aatgctcagt?180

ccgatttcct?tcttgggact?cgctggtagc?tcttatgcag?gtagctggat?tttatggttt?240

gctcaattag?ggatggtagt?agctattcca?ctgacaattc?gttttatctt?acctatcttt?300

gcacggatag?acatcgatac?ggcatatgat?tacttggata?aacgttttaa?ttctaaagca?360

cttcgtatta?tttcagcact?cttgtttatt?atttatcaat?tgggacgtat?gtctatcatt?420

atgtacctcc?catcagctgg?tttatcagta?ttgacaggaa?ttgacatcaa?tattttgatt?480

attttgatgg?gtgtagttgc?aattgtttat?tcttatactg?gtggtctaaa?atccgtatta?540

tggacagact?ttattcaagg?tgtgattctg?attagtggtg?tcgttttagc?tttatttgta?600

ctgattgcta?atattaaagg?tggctttggt?gcagtagcag?aaacattagc?aaacgggaaa?660

ttccttgctg?caaatgaaaa?acttttcgat?cctaacttgc?tttcaaactc?catcttttta?720

attgtgatgg?gttcaggctt?tacaatcttg?tcttcctatg?cttcatctca?agatttggtt?780

caacgtttta?ctacaacaca?aaatattaag?aaacttaata?agatgttgtt?cacaaacggt?840

gttttgtcac?ttgcaactgc?aacagtcttt?tacttgattg?gtacaggctt?gtacgtattc?900

tatcaagtac?aaaatgcaga?tagtgcagct?agcaatatcc?ctcaagacca?aatctttatg?960

tactttattg?cataccagtt?accagtaggt?atcacaggtt?tgatcttggc?agcgatttat?1020

gcagcatctc?aatcaactat?ttcaacaggt?ttgaactctg?ttgcaacttc?atggacattg?1080

gatattcaag?atgtcatttc?taaaaatatg?tcagacaatc?gtcgtacgaa?aattgcacaa?1140

ttcgtatctc?tagcagtagg?tttattctca?attggtgttt?ccattgtcat?ggctcactca?1200

gatattaaat?ctgcatacga?atggttcaat?agtttcatgg?gacttgtact?tggtctactt?1260

ggtggtgtat?ttattcttgg?atttgtttct?aaaaaagcaa?ataaacaagg?tgcttatgca?1320

gcgctgattg?tatcaaccat?cgtcatggta?tttattaaat?acttccttcc?tccaacagct?1380

gttagctact?gggcatattc?attgatttca?atctctgtat?cagtagtttc?aggttatatt?1440

gtatctgttc?ttactggaaa?taaagtatct?gcacctaaat?atacaacgat?tcatgatatt?1500

acagaaatta?aagcggattc?aagttgggaa?gttcgtcact?aa 1542

<210>206

<211>2481

<212>DNA

＜213〉streptococcus pneumoniae

<400>206

atgaaaatta?ataaaaaata?tctagcaggt?tcagtggcag?tccttgccct?aagtgtttgt?60

tcctatgagc?ttggtcgtca?ccaagctggt?caggataaga?aagagtctaa?tcgagttgct?120

tatatagatg?gtgatcaggc?tggtcaaaag?gcagaaaact?tgacaccaga?tgaagtcagt?180

aagagggagg?ggatcaacgc?cgaacaaatc?gtcatcaaga?ttacggatca?aggttatgtg?240

acctctcatg?gagaccatta?tcattactat?aatggcaagg?tcccttatga?tgccatcatc?300

agtgaagagc?tcctcatgaa?agatccgaat?tatcagttga?aggattcaga?cattgtcaat?360

gaaatcaagg?gtggttatgt?catcaaggta?gacggaaaat?actatgttta?ccttaaggat?420

gcagctcatg?cggataatat?tcggacaaaa?gaagagatta?aacgtcagaa?gcaggaacgc?480

agtcataatc?acgggtcagg?agctaacgat?catgcagtag?ctgcagccag?agcccaagga?540

cgctatacaa?cggatgatgg?gtatatcttc?aatgcatctg?atatcattga?ggacacgggt?600

gatgcttata?tcgttcctca?cggcgaccat?taccattaca?ttcctaagaa?tgagttatca?660

gctagcgagt?tagctgctgc?agaagcctat?tggaatggga?agcagggatc?tcgtccttct?720

tcaagttcta?gttataatgc?aaatccagct?caaccaagat?tgtcagagaa?ccacaatctg?780

actgtcactc?caacttatca?tcaaaatcaa?ggggaaaaca?tttcaagcct?tttacgtgaa?840

ttgtatgcta?aacccttatc?agaacgccat?gtggaatctg?atggccttat?tttcgaccca?900

gcgcaaatca?caagtcgaac?cgccagaggt?gtagctgtcc?ctcatggtaa?ccattaccac?960

tttatccctt?atgaacaaat?gtctgaattg?gaaaaacgaa?ttgctcgtat?tattcccctt?1020

cgttatcgtt?caaaccattg?ggtaccagat?tcaagaccag?aacaaccaag?tccacaatcg?1080

actccggaac?ctagtccaag?tccgcaacct?gcaccaaatc?ctcaaccagc?tccaagcaat?1140

ccaattgatg?agaaattggt?caaagaagct?gttcgaaaag?taggcgatgg?ttatgtcttt?1200

gaggagaatg?gagtttctcg?ttatatccca?gccaaggatc?tttcagcaga?aacagcagca?1260

ggcattgata?gcaaactggc?caagcaggaa?agtttatctc?ataagctagg?agctaagaaa?1320

actgacctcc?catctagtga?tcgagaattt?tacaataagg?cttatgactt?actagcaaga?1380

attcaccaag?atttacttga?taataaaggt?cgacaagttg?attttgaggc?tttggataac?1440

ctgttggaac?gactcaagga?tgtcccaagt?gataaagtca?agttagtgga?tgatattctt?1500

gccttcttag?ctccgattcg?tcatccagaa?cgtttaggaa?aaccaaatgc?gcaaattacc?1560

tacactgatg?atgagattca?agtagccaag?ttggcaggca?agtacacaac?agaagacggt?1620

tatatctttg?atcctcgtga?tataaccagt?gatgaggggg?atgcctatgt?aactccacat?1680

atgacccata?gccactggat?taaaaaagat?agtttgtctg?aagctgagag?agcggcagcc?1740

caggcttatg?ctaaagagaa?aggtttgacc?cctccttcga?cagaccatca?ggattcagga?1800

aatactgagg?caaaaggagc?agaagctatc?tacaaccgcg?tgaaagcagc?taagaaggtg?1860

ccacttgatc?gtatgcctta?caatcttcaa?tatactgtag?aagtcaaaaa?cggtagttta?1920

atcatacctc?attatgacca?ttaccataac?atcaaatttg?agtggtttga?cgaaggcctt?1980

tatgaggcac?ctaaggggta?tactcttgag?gatcttttgg?cgactgtcaa?gtactatgtc?2040

gaacatccaa?acgaacgtcc?gcattcagat?aatggttttg?gtaacgctag?cgaccatgtt?2100

caaagaaaca?aaaatggtca?agctgatacc?aatcaaacgg?aaaaaccaag?cgaggagaaa?2160

cctcagacag?aaaaacctga?ggaagaaacc?cctcgagaag?agaaaccgca?aagcgagaaa?2220

ccagagtctc?caaaaccaac?agaggaacca?gaagaatcac?cagaggaatc?agaagaacct?2280

caggtcgaga?ctgaaaaggt?tgaagaaaaa?ctgagagagg?ctgaagattt?acttggaaaa?2340

atccaggatc?caattatcaa?gtccaatgcc?aaagagactc?tcacaggatt?aaaaaataat?2400

ttactatttg?gcacccagga?caacaatact?attatggcag?aagctgaaaa?actattggct?2460

ttattaaagg?agagtaagta?a 2481

<210>207

<211>888

<212>DNA

＜213〉streptococcus pneumoniae

<400>207

atggagggat?tggttagagt?gcatttattg?cctgtatttg?gcgattacaa?gctatctaaa?60

cttactacgc?ctattcttca?acagcaagta?aacaaatggg?ctgacaaggc?aaataaaggc?120

gaaaaagggg?catttgctaa?ctactctttg?ctccataaca?tgaataagcg?tattttgaaa?180

tatggcgtag?ctatccaggt?aatacaatac?aacccagcta?atgatgtcat?cgttccacgc?240

aaacagcaaa?aagaaaaggc?tgctgtcaaa?tacttagaca?acaaagaatt?aaaacagttt?300

cttgattatt?tagatgctct?ggatcaatca?aattatgaga?acttatttga?tgttgttctg?360

tataagactt?tattggccac?tggttgccgt?attagtgagg?ctctggctct?tgaatggtct?420

gatattgacc?tagaaagcgg?tgttatcagc?atcaataaga?cactaaaccg?ctatcaggaa?480

ataaactcac?ctaaatcaag?cgctggttat?cgtgatatac?caatagacaa?agccacatta?540

cttttactga?aacaatacaa?aaaccgtcaa?caaattcagt?cttggaaatt?aggccgatct?600

gaaacagttg?tattctctgt?atttacggag?aaatatgctt?atgcttgtaa?cttacgcaaa?660

cgcctaaata?agcattttga?tgctgctgga?gtaactaacg?tatcatttca?tggtttccgc?720

catacacata?ctactatgat?gctctatgct?caggttagcc?cgaaagatgt?tcagtataga?780

ttaggccact?ctaatttaat?gatcactgaa?aatacttact?ggcatactaa?ccaagagaat?840

gcaaaaaaag?ccgtctcaaa?ttatgaaaca?gctatcaaca?atttataa 888

<210>208

<211>624

<212>DNA

＜213〉streptococcus pneumoniae

<400>208

atggaagagt?tagtgacctt?agattgtttg?tttattgaca?gaactaagat?tgaagccaat?60

gccaacaagt?atagttttgt?gtggaagaaa?acgacagaga?aattctccgc?caaacttcaa?120

gaacagatac?aggtctattt?tcaagaagaa?atcactcccc?ttctgattaa?atatgccatg?180

tttgataaga?aacaaaagag?agggtataaa?gagtcagcta?aaaacttagc?gaattggcac?240

tataatgaca?aggaggatag?ctacacacat?cctgatggct?ggtattatcg?ttttcaccat?300

accaaatatc?agaaaacaca?gacagacttt?caacaagaaa?tcaaggttta?ctacgccgac?360

gaacctgaat?cagcccctca?aaagggactg?tatatgaacg?aacgctatca?aaacttgaaa?420

gctaaagaat?gtcaggcgct?tttatctccc?caaggtagac?agattttcgc?tcaacgcaag?480

attgatgtgg?aacctgtctt?tgggcagata?aaggcttctt?tgggttacaa?gagatgtaat?540

ctgagaggga?agcgtcaagt?gagaattgac?atgggattgg?tacttatggc?caataacctc?600

ctaaaatata?gtaaaatgaa?ataa 624

<210>209

<211>6702

<212>DNA

＜213〉streptococcus pneumoniae

<400>209

atggggaaag?gccattggaa?tcggaaaaga?gtttatagca?ttcgtaagtt?tgctgtggga?60

gcttgctcag?taatgattgg?gacttgtgca?gttttattag?gaggaaatat?agctggagaa?120

tctgtagttt?atgcggatga?aacacttatt?actcatactg?ctgagaaacc?taaagaggaa?180

aaaatgatag?tagaagaaaa?ggctgataaa?gctttggaaa?ctaaaaatat?agttgaaagg?240

acagaacaaa?gtgaacctag?ttcaactgag?gctattgcat?ctgagaagaa?agaagatgaa?300

gccgtaactc?caaaagagga?aaaagtgtct?gctaaaccgg?aagaaaaagc?tccaaggata?360

gaatcacaag?cttcaaatca?agaaaaaccg?ctcaaggaag?atgctaaagc?tgtaacaaat?420

gaagaagtga?atcaaatgat?tgaagacagg?aaagtggatt?ttaatcaaaa?ttggtacttt?480

aaactcaatg?caaattctaa?ggaagccatt?aaacctgatg?cagacgtatc?tacgtggaaa?540

aaattagatt?taccgtatga?ctggagtatc?tttaacgatt?tcgatcatga?atctcctgca?600

caaaatgaag?gtggacagct?caacggtggg?gaagcttggt?atcgcaagac?tttcaaacta?660

gatgaaaaag?acctcaagaa?aaatgttcgc?cttacttttg?atggcgtcta?catggattct?720

caagtttatg?tcaatggtca?gttagtgggg?cattatccaa?atggttataa?ccagttctca?780

tatgatatca?ccaaatacct?tcaaaaagat?ggtcgtgaga?atgtgattgc?tgtccatgca?840

gtcaacaaac?agccaagtag?ccgttggtat?tcaggaagtg?gtatctatcg?tgatgtgact?900

ttacaagtga?cagataaggt?gcatgttgag?aaaaatggga?caactatttt?aacaccaaaa?960

cttgaagaac?aacaacatgg?caaggttgaa?actcatgtga?ccagcaaaat?cgtcaatacg?1020

gacgacaaag?accatgaact?tgtagccgaa?tatcaaatcg?ttgaacgagg?tggtcatgct?1080

gtaacaggct?tagttcgtac?agcgagtcgt?accttaaaag?cacatgaatc?aacaagccta?1140

gatgcgattt?tagaagttga?aagaccaaaa?ctctggactg?ttttaaatga?caaacctgcc?1200

ttgtacgaat?tgattacgcg?tgtttaccgt?gacggtcaat?tggttgatgc?taagaaggat?1260

ttgtttggtt?accgttacta?tcactggact?ccaaatgaag?gtttctcttt?gaatggtgaa?1320

cgtattaaat?tccatggagt?atccttgcac?cacgaccatg?gggcgcttgg?agcagaagaa?1380

aactataaag?cagaatatcg?ccgtctcaaa?caaatgaagg?agatgggagt?taactccatc?1440

cgtacaaccc?acaaccctgc?tagtgagcaa?accttgcaaa?tcgcagcaga?actaggttta?1500

ctcgttcagg?aagaggcctt?tgatacgtgg?tatggtggca?agaaacctta?tgactatgga?1560

cgtttctttg?aaaaagatgc?cactcaccca?gaagctcgaa?aaggtgaaaa?atggtctgat?1620

tttgacctac?gtaccatggt?cgaaagaggc?aaaaacaacc?ctgctatctt?catgtggtca?1680

attggtaatg?aaataggtga?agctaatggt?gatgcccact?ctttagcaac?tgttaaacgt?1740

ttggttaagg?ttatcaagga?tgttgataag?actcgctatg?ttaccatggg?agcagataaa?1800

ttccgtttcg?gtaatggtag?cggagggcat?gagaaaattg?ctgatgaact?cgatgctgtt?1860

ggatttaact?attctgaaga?taattacaaa?gcccttagag?ctaagcatcc?aaaatggttg?1920

atttatggat?cagaaacatc?ttcagctacc?cgtacacgtg?gaagttacta?tcgccctgaa?1980

cgtgaattga?aacatagcaa?tggacctgag?cgtaattatg?aacagtcaga?ttatggaaat?2040

gatcgtgtgg?gttgggggaa?aacagcaacc?gcttcatgga?cttttgaccg?tgacaacgct?2100

ggctatgctg?gacagtttat?ctggacaggt?acggactata?ttggtgaacc?tacaccatgg?2160

cacaaccaaa?atcaaactcc?tgttaagagc?tcttactttg?gtatcgtaga?tacagccggc?2220

attccaaaac?atgacttcta?tctctaccaa?agccaatggg?tttctgttaa?gaagaaaccg?2280

atggtacacc?ttcttcctca?ctggaactgg?gaaaacaaag?aattagcatc?caaagtagct?2340

gactcagaag?gtaagattcc?agttcgtgct?tattcgaatg?cttctagtgt?agaattgttc?2400

ttgaatggaa?aatctcttgg?tcttaagact?ttcaataaaa?aacaaaccag?cgatgggcgg?2460

acttaccaag?aaggtgcaaa?tgctaatgaa?ctttatcttg?aatggaaagt?tgcctatcaa?2520

ccaggtacct?tggaagcaat?tgctcgtgat?gaatctggca?aggaaattgc?tcgagataag?2580

attacgactg?ctggtaagcc?agcggcagtt?cgtcttatta?aggaagacca?tgcgattgca?2640

gcagatggaa?aagacttgac?ttacatctac?tatgaaattg?ttgacagcca?ggggaatgtg?2700

gttccaactg?ctaataatct?ggttcgcttc?caattgcatg?gccaaggtca?actggtcggt?2760

gtagataacg?gagaacaagc?cagccgtgaa?cgctataagg?cgcaagcaga?tggttcttgg?2820

attcgtaaag?catttaatgg?taaaggtgtt?gccattgtca?aatcaactga?acaagcaggg?2880

aaattcaccc?tgactgccca?ctctgatctc?ttgaaatcga?accaagtcac?tgtctttact?2940

ggtaagaaag?aaggacaaga?gaagactgtt?ttggggacag?aagtgccaaa?agtacagacc?3000

attattggag?aggcacctga?aatgcctacc?actgttccgt?ttgtatacag?tgatggtagc?3060

cgtgcagaac?gtcctgtaac?ctggtcttca?gtagatgtga?gcaagcctgg?tattgtaacg?3120

gtgaaaggta?tggctgacgg?acgagaagta?gaagctcgtg?tagaagtgat?tgctcttaaa?3180

tcagagctac?cagttgtgaa?acgtattgct?ccaaatactg?acttgaattc?tgtagacaaa?3240

tctgtttcct?atgttttgat?tgatggaagt?gttgaagagt?atgaagtgga?caagtgggag?3300

attgccgaag?aagataaagc?taagttagca?attccaggtt?ctcgtattca?agcgaccggt?3360

tatttagaag?gtcaaccaat?tcatgcaacc?cttgtggtag?aagaaggcaa?tcctgcggca?3420

cctgcagtac?caactgtaac?ggttggtggt?gaggcagtaa?caggtcttac?tagtcaaaaa?3480

ccaatgcaat?accgcactct?tgcttatgga?gctaagttgc?cagaagtcac?agcaagtgct?3540

aaaaatgcag?ctgttacagt?tcttcaagca?agcgcagcaa?acggcatgcg?tgcgagcatc?3600

tttattcagc?ctaaagatgg?tggccctctt?caaacctatg?caattcaatt?ccttgaagaa?3660

gcgccaaaaa?ttgctcactt?gagcttgcaa?gtggaaaaag?ctgacagtct?caaagaagac?3720

caaactgtca?aattgtcggt?tcgagctcac?tatcaagatg?gaacgcaagc?tgtattacca?3780

gctgataaag?taaccttctc?tacaagtggt?gaaggggaag?tcgcaattcg?taaaggaatg?3840

cttgagttgc?ataagccagg?agcagtcact?ctgaacgctg?aatatgaggg?agctaaagac?3900

caagttgaac?tcactatcca?agccaatact?gagaagaaga?ttgcgcaatc?catccgtcct?3960

gtaaatgtag?tgacagattt?gcatcaggaa?ccaagtcttc?cagcaacagt?aacagttgag?4020

tatgacaaag?gtttccctaa?aactcataaa?gtcacttggc?aagctattcc?gaaagaaaaa?4080

ctagactcct?atcaaacatt?tgaagtacta?ggtaaagttg?aaggaattga?ccttgaagcg?4140

cgtgcaaaag?tctctgtaga?aggtatcgtt?tcagttgaag?aagtcagtgt?gacaactcca?4200

atcgcagaag?caccacaatt?accagaaagt?gttcggacat?atgattcaaa?tggtcacgtt?4260

tcatcagcta?aggttgcatg?ggatgcgatt?cgtccagagc?aatacgctaa?ggaaggtgtc?4320

tttacagtta?atggtcgctt?agaaggtacg?caattaacaa?ctaaacttca?tgttcgcgta?4380

tctgctcaaa?ctgagcaagg?tgcaaacatt?tctgaccaat?ggaccggttc?agaattgcca?4440

cttgcctttg?cttcagactc?aaatccaagc?gacccagttt?caaatgttaa?tgacaagctc?4500

atttcctaca?ataaccaacc?agccaatcgt?tggacaaact?ggaatcgtac?taatccagaa?4560

gcttcagtcg?gtgttctgtt?tggagattca?ggtatcttga?gcaaacgctc?cgttgataat?4620

ctaagtgtcg?gattccatga?agaccatgga?gttggtgtac?cgaagtctta?tgtgattgag?4680

tattatgttg?gtaagactgt?cccaacagct?cctaaaaacc?ctagttttgt?tggtaatgag?4740

gaccatgtct?ttaatgattc?tgccaactgg?aaaccagtta?ctaatctaaa?agcccctgct?4800

caactcaagg?ctggagaaat?gaaccacttt?agctttgata?aagttgaaac?ctatgctgtt?4860

cgtattcgca?tggttaaagc?agataacaag?cgtggaacgt?ctatcacaga?ggtacaaatc?4920

tttgcgaaac?aagttgcggc?agccaagcaa?ggacaaacaa?gaatccaagt?tgacggcaaa?4980

gacttagcaa?acttcaaccc?tgatttgaca?gactactacc?ttgagtctgt?agatggaaaa?5040

gttccggcag?tcacagcaag?tgttagcaac?aatggtctcg?ctaccgtcgt?tccaagcgtt?5100

cgtgaaggtg?agccagttcg?tgtcatcgcg?aaagctgaaa?atggcgacat?cttaggagaa?5160

taccgtctgc?acttcactaa?ggataagagc?ttactttctc?ataaaccagt?tgctgcggtt?5220

aaacaagctc?gcttgctaca?agtaggtcaa?gcacttgaat?tgccgactaa?ggttccagtt?5280

tacttcacag?gtaaagacgg?ctacgaaaca?aaagacctga?cagttgaatg?ggaagaagtt?5340

ccagcggaaa?atctgacaaa?agcaggtcaa?tttactgttc?gaggccgtgt?ccttggtagt?5400

aaccttgttg?ctgagatcac?tgtacgagtg?acagacaaac?ttggtgagac?tctttcagat?5460

aaccctaact?atgatgaaaa?cagtaaccag?gcctttgctt?cagcaaccaa?tgatattgac?5520

aaaaactctc?atgaccgcgt?tgactatctc?aatgacggag?atcattcaga?aaatcgtcgt?5580

tggacaaact?ggtcaccaac?accatcttct?aatccagaag?tatcagcggg?tgtgattttc?5640

cgtgaaaatg?gtaagattgt?agaacggact?gttacacaag?gaaaagttca?gttctttgca?5700

gatagtggta?cggatgcacc?atctaaactc?gttttagaac?gctatgtcgg?tccagagttt?5760

gaagtgccaa?cctactattc?aaactaccaa?gcctacgacg?cagaccatcc?attcaacaat?5820

ccagaaaatt?gggaagctgt?tccttatcgt?gcggataaag?acattgcagc?tggtgatgaa?5880

atcaacgtaa?catttaaagc?tatcaaagcc?aaagctatga?gatggcgtat?ggagcgtaaa?5940

gcagataaga?gcggtgttgc?gatgattgag?atgaccttcc?ttgcaccaag?tgaattgcct?6000

caagaaagca?ctcaatcaaa?gattcttgta?gatggaaaag?aacttgctga?tttcgctgaa?6060

aatcgtcaag?actatcaaat?tacctataaa?ggtcaacggc?caaaagtctc?agttgaagaa?6120

aacaatcaag?tagcttcaac?tgtggtagat?agtggagaag?atagctttcc?agtacttgtt?6180

cgcctcgttt?cagaaagtgg?aaaacaagtc?aaggaatacc?gtatccactt?gactaaggaa?6240

aaaccagttt?ctgagaagac?agttgctgct?gtacaagaag?atcttccaaa?aatcgaattt?6300

gttgaaaaag?atttggcata?caagacagtt?gagaaaaaag?attcaacact?gtatctaggt?6360

gaaactcgtg?tagaacaaga?aggaaaagtt?ggaaaagaac?gtatctttac?agcgattaat?6420

cctgatggaa?gtaaggaaga?aaaactccgt?gaagtggtag?aagttccgac?agaccgcatc?6480

gtcttggttg?gaaccaaacc?agtagctcaa?gaagctaaaa?aaccacaagt?gtcagaaaaa?6540

gcagatacaa?aaccaattga?ttcaagtgaa?gctagtcaaa?ctaataaagc?ccagttacca?6600

agtacaggta?gtgcggcaag?ccaagcagca?gtagcagcag?gtttaactct?tctaggtttg?6660

agtgcaggat?tagtagttac?taaaggtaaa?aaagaagact?ag 6702

<210>210

<211>1476

<212>DNA

＜213〉streptococcus pneumoniae

<400>210

atggatgcaa?tctttgacct?aatcggaaag?gttttcaatc?ccatcttaga?aatgggtgga?60

cctgtcatca?tgttaatcat?tttgacagta?ttggctttac?tttttggagt?gaaattctcc?120

aaagcgcttg?aaggtggtat?caaacttgcc?atcgctctta?caggtatcgg?tgctatcatc?180

ggtatgctaa?acactgcttt?ctcagcatca?ctagcaaaat?tcgttgaaaa?cactggtatc?240

caattgagta?ttaccgacgt?tggttgggca?ccacttgcta?caatcacttg?gggttctgct?300

tggacactat?acttcttgct?catcatgttg?attgtcaaca?tagtgatgct?agctatgaag?360

aaaacagata?cacttgatgt?cgatatcttt?gatatctggc?acttgtctat?cacaggtctc?420

ttgattaaat?ggtatgctga?taacaatggt?gtgagtcaag?gggtttcact?ctttattgct?480

acagcagcta?tcgtccttgt?cggtgtgttg?aaaattatca?actctgactt?gatgaaacct?540

acatttgatg?accttcttaa?cgccccaagt?tcatcaccaa?tgacatcaac?tcacatgaac?600

tacatgatga?acccagttat?catggttttg?gataagattt?ttgaaaaatt?cttcccaggc?660

cttgataaat?atgactttga?tgctgctaaa?ttgaacaaga?aaatcggttt?ctggggatct?720

aaattcttca?tcggtttcat?ccttggtatc?gttatcggta?ttatgggaac?tccacatcca?780

attgcaggtg?ttgcagatgc?agataaatgg?cgtcttgtta?tcaaaggatg?gttgtctctt?840

ggtttgactg?ccggtgtatc?tttggaactc?ttctcactta?tcggttcatg?gttcatcgca?900

gccgtagaac?cactatcaca?aggtattaca?aacgttgcta?ctaaacgtct?tcaaggacgt?960

aaattcaata?tcggtcttga?ctggccattc?atcgctggtc?gtgctgaaat?ctgggcttgt?1020

gccaacgtac?ttgcaccaat?catgttgatt?gaagcagtgc?ttctttcaaa?agttggaaat?1080

ggtatcttgc?cacttgcagg?tatcatcgct?atgggtgtta?ctccagctct?cttggttgta?1140

actcgtggta?aattgctccg?tatgattatc?ttcggaacac?tcttgttgcc?actcttcctt?1200

ctttcaggta?cacttattgc?accatttgca?acagaacttg?ctaaaggtgt?aggtgccttc?1260

ccagaaggtg?tgagccaaac?tcaattgatt?actcactcta?ctcttgaagg?accaatcgaa?1320

aaacttcttg?gttggacaat?tggtaacact?acaactggtg?atatcaaagc?aatccttggt?1380

gcagtagtct?tccttgtatt?ctatatcggt?atctttgctt?ggtacagaaa?acaaatgatc?1440

aaacgtaacg?aagagtacgc?agcaaaagca?aaataa 1476

<210>211

<211>1413

<212>DNA

＜213〉streptococcus pneumoniae

<400>211

atgaagatta?tgaaaaaaaa?atattggact?ttagcgatat?tattcttttg?tttgttcaat?60

aattctgtta?ctgctcaaga?aatacctaaa?aatcttgatg?gcaatataac?tcacactcag?120

actagcgaaa?gtttttctga?atctgatgaa?aaacaggttg?actattctaa?taaaaatcaa?180

gaagaagtag?accaaaataa?atttcgtatt?caaatcgata?agacagaatt?atttgtaaca?240

acagataaac?atttagaaaa?aaactgttgt?aaattggaac?ttgaaccaca?aataaataac?300

gatattgtta?actctgaaag?taataattta?ctaggcgaag?ataatttaga?taataaaatt?360

aaggaaaatg?tttctcatct?agataataga?ggaggaaata?tagagcatga?caaagataac?420

ttagaatcgt?cgattgtaag?aaaatatgaa?tgggatatag?ataaagttac?tggtggaggc?480

gaaagttata?aattatattc?taaaagtaat?tctaaagttt?caattgctat?tttagattca?540

ggagtcgatt?tacaaaatac?tggattactg?aaaaatcttt?caaatcactc?aaaaaactat?600

gtccccaata?aaggatattt?aggaaaagag?gagggagagg?aaggaataat?atcagatatt?660

caagatagat?taggtcatgg?tacggctgtt?gtagctcaaa?ttgtagggga?tgacaatatt?720

aatggagtaa?atcctcacgt?taatattaac?gtctatagaa?tatttggtaa?gtcgtcagct?780

agtccagatt?ggattgtaaa?agcaattttt?gatgctgtag?atgatggcaa?tgatattatc?840

aatcttagta?ctggacaata?tttaatgatt?gatggagaat?atgaggacgg?aacaaatgat?900

tttgaaacat?ttttgaagta?taaaaaggct?attgattacg?cgaatcaaaa?aggagtaatt?960

atagtagctg?cattagggaa?tgactcccta?aatgtatcaa?atcagtcaga?tttattgaaa?1020

cttattagtt?cacgcaaaaa?agtaagaaaa?ccaggattag?tagttgatgt?tccaagttat?1080

ttctcatcta?caatttcggt?cggaggcata?gatcgcttag?gtaatttatc?agattttagc?1140

aataaagggg?attctgatgc?aatatatgcg?cctgcaggct?caacattatc?tctttcagaa?1200

ttaggactta?ataactttat?taatgcagaa?aaatataaag?aagattggat?tttttcggca?1260

acactaggag?gatatacgta?tctttatgga?aactcatttg?ctgctcctaa?agtttctggt?1320

gcgattgcaa?tgattattga?taaatacaaa?ttaaaagatc?agccctataa?ttatatgttt?1380

gtaaaaaaat?tctggaagaa?acattaccag?taa 1413

<210>212

<211>1008

<212>DNA

＜213〉streptococcus pneumoniae

<400>212

atgaagaaaa?catggaaagt?gtttttaacg?cttgtaacag?ctcttgtagc?tgttgtgctt?60

gtggcctgtg?gtcaaggaac?tgcttctaaa?gacaacaaag?aggcagaact?taagaaggtt?120

gactttatcc?tagactggac?accaaatacc?aaccacacag?ggctttatgt?tgccaaggaa?180

aaaggttatt?tcaaagaagc?tggagtggat?gttgatttga?aattgccacc?agaagaaagt?240

tcttctgact?tggttatcaa?cggaaaggca?ccatttgcag?tgtatttcca?agactacatg?300

gctaagaaat?tggaaaaagg?agcaggaatc?actgccgttg?cagctattgt?tgaacacaat?360

acatcaggaa?tcatctctcg?taaatctgat?aatgtaagca?gtccaaaaga?cttggttggt?420

aagaaatatg?ggacatggaa?tgacccaact?gaacttgcta?tgttgaaaac?cttggtagaa?480

tctcaaggtg?gagactttga?gaaggttgaa?aaagtaccaa?ataacgactc?aaactcaatc?540

acaccgattg?ccaatggcgt?ctttgatact?gcttggattt?actacggttg?ggatggtatc?600

cttgctaaat?ctcaaggtgt?agatgctaac?ttcatgtact?tgaaagacta?tgtcaaggag?660

tttgactact?attcaccagt?tatcatcgca?aacaacgact?atctgaaaga?taacaaagaa?720

gaagctcgca?aagtcatcca?agccatcaaa?aaaggctacc?aatatgccat?ggaacatcca?780

gaagaagctg?cagatattct?catcaagaat?gcacctgaac?tcaaggaaaa?acgtgacttt?840

gtcatcgaat?ctcaaaaata?cttgtcaaaa?gaatacgcaa?gcgacaagga?aaaatggggt?900

caatttgacg?cagctcgctg?gaatgctttc?tacaaatggg?ataaagaaaa?tggtatcctt?960

aaagaagact?tgacagacaa?aggcttcacc?aacgaatttg?tgaaataa 1008

<210>213

<211>1332

<212>DNA

＜213〉streptococcus pneumoniae

<400>213

atgataaaaa?atcctaaatt?attaaccaag?tcttttttaa?gaagttttgc?aattctaggt?60

ggtgttggtc?tagtcattca?tatagctatt?tatttgacct?ttccttttta?ttatattcaa?120

ctggaggggg?aaaagtttaa?tgagagcgca?agagtgttta?cggagtattt?aaagactaag?180

acatctgatg?aaattccaag?cttactccag?tcttattcaa?agtccttgac?catatctgct?240

caccttaaaa?gagatattgt?agataagcgg?ctccctcttg?tgcatgactt?ggatattaaa?300

gatggaaagc?tatcaaatta?tatcgtgatg?ttagatatgt?ctgttagtac?agcagatggt?360

aaacaggtaa?ccgtgcaatt?tgttcacggg?gtggatgtct?acaaagaagc?aaagaatatt?420

ttgcttttgt?atctcccata?tacatttttg?gttacaattg?ctttttcctt?tgttttttct?480

tatttttata?ctaaacgctt?gctcaatcct?cttttttaca?tttcagaagt?gactagtaaa?540

atgcaagatt?tggatgacaa?tattcgtttt?gatgaaagta?ggaaagatga?agttggtgaa?600

gttggaaaac?agattaatgg?tatgtatgag?cacttgttga?aggttattta?tgagttggaa?660

agtcgtaatg?agcaaattgt?aaaattgcaa?aatcaaaagg?tttcctttgt?ccgcggagca?720

tcacatgagt?tgaaaacccc?tttagccagt?cttagaatta?tcctagagaa?tatgcagcat?780

aatattggag?attacaaaga?tcatccaaaa?tatattgcaa?agagtataaa?taagattgac?840

cagatgagcc?acttattaga?agaagtactg?gagtcttcta?aattccaaga?gtggacagag?900

tgtcgtgaga?ccttgactgt?taagccagtt?ttagtagata?ttttatcacg?ttatcaagaa?960

ttagctcatt?caataggtgt?tacaattgaa?aatcaattga?cagatgctac?cagggtcgtc?1020

atgagtctta?gggcattgga?taaggttttg?acaaacctga?ttagtaatgc?aattaaatat?1080

tcagataaaa?atgggcgtgt?aatcatatcc?gagcaagatg?gctatctctc?tatcaaaaat?1140

acatgtgcgc?ctctaagtga?ccaagaacta?gaacatttat?ttgatatatt?ctatcattct?1200

caaatcgtga?cagataagga?tgaaagttcc?ggtttgggtc?tttacattgt?gaataatatt?1260

ttagaaagct?atcaaatgga?ttatagtttt?ctcccttatg?aacacggtat?ggaatttaag?1320

attagcttgt?ag 1332

<210>214

<211>1428

<212>DNA

＜213〉streptococcus pneumoniae

<400>214

atgtatttag?gagatttgat?ggagaaagcc?gagtgtggtc?aattttcaat?actttccttt?60

ctattacaag?agtctcagac?gaccgtcaag?gctgtaatgg?aagaaacagg?attttcaaaa?120

gcaaccctaa?ccaaatatgt?caccctgctc?aatgacaagg?ctttggatag?tggcttagag?180

ctggctattc?actcagaaga?tgaaaatctg?cgtctgtcta?tcggtgcagc?taccaagggg?240

agagatattc?ggagcttgtt?tttggagagt?gctgttaaat?accagatttt?ggtttatctt?300

ctctaccacc?aacagttttt?agcccatcag?ctggctcaag?aattggtgat?tagcgaggct?360

acgcttggtc?gtcacttggc?tggtttaaat?cagattttgt?cagaatttga?tttatccatc?420

caaaatggcc?gttggcgagg?tccagagcat?cagattcact?atttctattt?ctgtcttttc?480

cgaaaggtct?ggtcgagtca?ggaatgggaa?ggtcacatgc?agaaaccaga?gagaaaacag?540

gagattgcca?atttagagga?aatctgcggt?gcaagtttgt?ctgcggggca?gaaattggac?600

ttggttctct?gggctcacat?cagtcaacaa?cgtcttcggg?tcaatgcttg?tcagtttcaa?660

gtcatagaag?agaaaatgcg?agggtatttt?gacaatatct?tttatcttcg?tttgctgaga?720

aaggttccgt?ccttttttgc?tgggcaacat?attccactag?gagttgagga?tggtgagatg?780

atgatattct?tctcttttct?cctatctcat?cgcattcttc?ctcttcatac?tatggagtat?840

attcttggtt?ttggagggca?gttggcagat?ttactgacgc?aattgattca?agaaatgaag?900

aaggaggaac?tattggggga?ttatacagag?gaccatgtca?cctatgaact?cagtcagctt?960

tgtgctcaag?tctatctcta?taagggctat?attttacagg?atcgctacaa?gtaccagtta?1020

gagaatcgtc?atccatattt?actgatggaa?catgatttta?aagagacagc?agaggagatt?1080

tttcatgctc?tacctgcttt?tcaacagggg?acagatttag?ataagaagat?tctctgggaa?1140

tggctccagt?taatcgaata?tatggctgaa?aacggtggcc?agcatatgcg?gattggtctg?1200

gatttgacat?ctggttttct?tgtcttttca?aggatggcag?ccattttgaa?acggtatttg?1260

gaatacaatc?gttttattac?cattgaagct?tatgacccta?gtcggcatta?tgatttgctg?1320

gttaccaata?acccgattca?taagaaggaa?cagacaccag?tctattattt?aaaaaatgac?1380

ttggatatgg?aggatttggt?agcgattcgc?cagttattat?tcacttaa 1428

<210>215

<211>1827

<212>DNA

＜213〉streptococcus pneumoniae

<400>215

atggaatttt?caaagaaaac?acgtgaattg?tcaattaaaa?aaatgcagga?acgtaccctg?60

gacctcttga?ttatcggtgg?aggaatcaca?ggagctggtg?tagccttgca?ggcggcagct?120

agcggtcttg?agactggttt?gattgaaatg?caagactttg?cagaaggaac?atctagtcgt?180

tcaacaaaat?tggttcacgg?aggacttcgt?tacctcaaac?aatttgacgt?agaagtggtc?240

tcagatacgg?tttctgaacg?tgcagtggtt?caacaaatcg?ctccacacat?tccaaaatca?300

gatccaatgc?tcttaccagt?ttacgatgaa?gatggagcaa?cctttagcct?cttccgtctt?360

aaagtagcca?tggacttgta?cgacctcttg?gcaggtgtta?gcaacacacc?agctgcgaac?420

aaggttttga?gcaaggatca?agtcttggaa?cgccagccaa?acttgaagaa?ggaaggcttg?480

gtaggaggtg?gagtgtatct?tgacttccgt?aacaacgatg?cgcgtctcgt?gattgaaaac?540

atcaaacgtg?ccaaccaaga?cggtgccctc?attgccaacc?acgtgaaggc?agaaggcttc?600

ctctttgacg?aaagtggcaa?gattacaggt?gttgtagctc?gtgatctctt?gacagaccaa?660

gtgtttgaaa?tcaaggcccg?tctggttatt?aatacaacag?gtccttggag?tgataaagta?720

cgtaatttgt?ctaataaggg?aacgcaattc?tcacaaatgc?gcccaactaa?gggagttcac?780

ttggtagtag?attcaagcaa?aatcaaggtt?tcacagccag?tttacttcga?cacaggtttg?840

ggtgacggtc?gtatggtctt?tgttctccca?cgtgaaaaca?agacttactt?tggtacaact?900

gatacagact?acacaggtga?tttggagcat?ccaaaagtaa?ctcaagaaga?tgtagattat?960

ctacttggca?ttgtcaacaa?ccgcttccca?gaatccaaca?tcaccattga?tgatatcgaa?1020

agcagctggg?caggtcttcg?tccattgatt?gcagggaaca?gtgcctctga?ctataatggt?1080

ggaaataacg?gtaccatcag?tgatgaaagc?tttgacaact?tgattgcgac?tgttgaatct?1140

tatctctcca?aagaaaaaac?acgtgaagat?gttgagtctg?ctgtcagcaa?gcttgaaagt?1200

agcacatctg?agaaacattt?ggatccatct?gcagtttctc?gtgggtctag?cttggaccgt?1260

gatgacaatg?gtctcttgac?tcttgctggt?ggtaaaatca?cagactaccg?taagatggct?1320

gaaggagcta?tggagcgcgt?ggttgacatc?ctcaaagcag?aatttgaccg?tagctttaaa?1380

ttgatcaatt?ctaaaactta?ccctgtttca?ggtggagaat?tgaacccagc?aaatgtggat?1440

tcagaaatcg?aagcctttgc?gcaacttgga?gtatcacgtg?gtttggatag?caaggaagct?1500

cactatctgg?caaatcttta?cggttcaaat?gcaccgaaag?tctttgcact?tgctcacagc?1560

ttggaacaag?cgccaggact?cagcttggca?gatactttgt?cccttcacta?tgcaatgcgc?1620

aatgagttga?ctcttagccc?agttgacttc?cttcttcgtc?gtaccaatca?catgctcttt?1680

atgcgtgata?gcttggatag?tatcgttgag?ccaattttgg?atgaaatggg?acgattctat?1740

gactggacag?aagaagaaaa?agcaacttac?cgtgctgatg?tcgaagcagc?tctcgctaac?1800

aacgatttag?cagaattaaa?aaattaa 1827

<210>216

<211>705

<212>DNA

＜213〉streptococcus pneumoniae

<400>216

atgatgaatg?aattatttgg?agaatttcta?gggactttaa?tcctgattct?tctaggaaat?60

ggtgttgttg?caggtgtggt?tcttcctaaa?accaagagca?atagctcagg?ttggattgtg?120

attactatgg?gttgggggat?tgcagttgcg?gttgcagtct?ttgtatctgg?caagctcagt?180

ccagcttatt?taaacccagc?tgtgaccatc?ggtgtggcct?taaaaggtgg?tttgccttgg?240

gcttccgttt?tgccttatat?cttagcccag?ttcgcagggg?ccatgctggg?tcagattttg?300

gtttggttgc?aattcaaacc?tcactatgag?gcagaagaaa?atgcaggcaa?tatcctggca?360

accttcagta?ctggaccagc?catcaaggat?actgtatcaa?acttgattag?cgaaatcctt?420

ggaacttttg?ttttggtgtt?gacaatcttt?gctttgggtc?tttacgactt?tcaggcaggt?480

atcggaacct?ttgcagtggg?aactttgatt?gtcggtatcg?gtctatcact?aggtgggaca?540

acaggttatg?ccttgaaccc?agctcgtgac?cttggacctc?gtatcatgca?cagcatcttg?600

ccaattccaa?acaagggaga?cggagactgg?tcttacgctt?ggattcctgt?tgtaggccct?660

gttatcggag?cagccttggc?agtgcttgta?ttctcacttt?tctag 705

<210>217

<211>1008

<212>DNA

＜213〉streptococcus pneumoniae

<400>217

atgaaaagga?cctggaggaa?ctcattcgtg?acaaatctta?atacaccttt?tatgattggc?60

aatattgaga?ttcccaatcg?taccgtttta?gcgcctatgg?ctggcgtgac?caactcagcc?120

tttcgtacta?tcgcaaagga?gctcggagct?ggactcgttg?taatggaaat?ggtctctgac?180

aagggaatcc?aatacaacaa?cgaaaaaacc?ctgcacatgc?ttcatatcga?tgagggcgaa?240

aaccctgtct?ctatccaact?ttttggtagc?gatgaagaca?gcctagcacg?cgcagcagaa?300

ttcatccaag?aaaacaccaa?gaccgatatc?gtcgatatca?acatgggctg?ccctgtcaac?360

aaaatcgtga?agaacgaagc?tggtgctatg?tggctcaagg?atccagacaa?gatttactcc?420

atcatcaaca?aggtccagtc?tgtccttgat?atcccactta?ctgtcaaaat?gcgtaccggc?480

tgggcggacc?catctcttgc?agtagaaaat?gctctcgctg?ctgaagctgc?aggtgtttct?540

gccctcgcca?tgcatggccg?tacccgtgaa?caaatgtata?ctggccacgc?agaccttgag?600

accctttaca?aggttgccca?agctctaacc?aagattccat?tcatcgccaa?cggtgatatc?660

cgtactgtcc?aagaagccaa?gcaacgcatc?gaagaagttg?gtgctgacgc?agtcatgatt?720

ggccgagctg?ccatgggaaa?tccttacctc?ttcaaccaaa?tcaaccatta?ctttgaaaca?780

ggagaaatcc?tacctgattt?gacctttgaa?gacaagatga?agatcgccta?cgaacacttg?840

aaacgattga?ttaacctcaa?aggagaaaac?gtcgcagttc?gtgaattccg?cggtctcgct?900

cctcactatc?tccgtggaac?atctggcgct?gccaaactcc?gtggagccat?ttcgcaagcc?960

agcaccctgg?cagagattga?aaccctcttg?caattggaga?aggcttaa 1008

<210>218

<211>411

<212>DNA

＜213〉streptococcus pneumoniae

<400>218

atgacaaaga?agaaaattga?gcgtatttct?gtaatacacc?gagaaaagat?tttatggctc?60

aagtggtatt?tcatgcgaga?taaagaacaa?cctaagtata?gtgtccttga?gcgtaaaatg?120

tttgatgctg?ctaaaaatca?agatatgcta?gcttatcaaa?aatacgcaac?tatcaagcag?180

ataacagata?ttagggtaca?aacaagtgag?gctgacattt?tagaggctgt?aaaagaggtt?240

tatgtgtaca?atcacatgaa?tgttatcgga?gcttgtcagc?ggatattatt?tatcagtcaa?300

tcaccagctt?atgataagtt?aaataagtgg?tttaatatct?attctgattt?gtattttagc?360

gttgtaccct?tgcccaaaat?gggggtatat?catgagatgg?taggtatcta?g 411

<210>219

<211>3300

<212>DNA

＜213〉streptococcus pneumoniae

<400>219

atgaaaaatt?ccaacgaggc?tgagatgaaa?ttactttata?ctgatattcg?gacttctttg?60

acagaaattc?taacaagaga?ggcagaagag?ctagttgcag?ctggcaagcg?ggtcttctac?120

attgccccca?actctctttc?ttttgaaaag?gaacgcgccg?tgctggaata?cttgtcccag?180

caggcttctt?tttcgattac?cgtcacgcgc?tttgctcaaa?tggctcgcta?tctggtcttg?240

aatgatttac?cagctaaaac?tactcttgat?gatatcggtc?ttgggttggc?cttttacaaa?300

tgccttgccg?aactcgatcc?caaggacttg?cgtgtttatg?gcgctattaa?gcaggatcct?360

caattgatcc?agcagttaat?tgagctttac?catgagatga?ccaaatctca?gatgagtttt?420

ttggacttgg?agaatttaac?agatgaggat?aagagggcgg?atttactctt?gatttttgag?480

aaagtaacag?cctatcttaa?tcaaggtcag?ttagcccagg?aaagtcagtt?gtcccatttg?540

attgaggcta?ttgagaatga?caaggtaagt?agtgatttta?atcaaatcgc?cttggtcatt?600

gacggcttta?ctcgtttttc?tgctgaggaa?gagcgggttg?tggacttact?tcacggcaaa?660

ggtgttgaga?ttgttatcgg?ggcttatgct?agtaagaaag?cctataccag?tccttttagc?720

gagggcaatc?tctaccaagc?cagcgtaaaa?tttctccatc?atctggcttc?taaataccaa?780

acgcctgctc?aggactgttc?tcaaactcat?gagaagatgg?atagttttga?caaggcctct?840

cgtttgttgg?agtcttctta?tgacttttca?gaactcgctt?tggatgtcga?tgagaaagac?900

cgtgaaaatt?tacaaatctg?gtcttgtttg?acgcaaaagg?aggagttgga?gctagtagcc?960

cgtagtattc?gtcagaaatt?acatgagaac?tcagacctga?gctacaagca?ttttcgtatt?1020

ctcttggggg?atgtagcttc?ttaccagtta?tctctcaaaa?ccatttttga?ccagtatcag?1080

attccttttt?atcttggtag?aagcgaagcc?atggctcatc?atcccttgac?tcagtttgtc?1140

gagtctattt?tagctttaaa?acgttaccgt?tttcgtcagg?aggatttgat?taatcttctt?1200

agaactgatt?tgtatactga?cctcagtcag?tctgatattg?atgcttttga?gcaatatatc?1260

cgctatcttg?gtatcaatgg?cttgccagcc?tttcagcaaa?ccttcaccaa?atcccaccat?1320

ggaaaattta?atcttgagcg?tttgaatgtc?ctccgcctga?gaattttagc?acctcttgaa?1380

accctctttg?ccagccgaaa?acaaaaggct?gaaaaactcc?tacaaaaatg?gagtgtcttt?1440

ctaaaagaag?gagctgtgac?caagcagtta?caagatttga?caaccacttt?ggaagctgta?1500

gaacaggaaa?gacaagccga?agtttggaag?gctttctgcc?atgttttaga?acaatttgcg?1560

actgtttttg?ctggttcaca?ggttagtctg?gaagacttcc?tagccttgct?ccattctgga?1620

atgagtttgt?cccaataccg?taccattcca?gcaacagtgg?acactgttct?ggtgcagagt?1680

tacgatttga?ttgcaccatt?gactgctgac?tttgtctatg?ctattggact?aactcaggac?1740

aatttaccaa?aaatttctca?aaacaccagt?cttctgacag?atgaagaaag?gcaaaaccta?1800

aaccaagcga?ccgaagaagg?cgttcaatta?ctgattgcca?gcagtgaaaa?tctcaagaaa?1860

aatcgctaca?ctatgctttc?cttggtcaat?tctgctcgta?agcagttgtt?cttgtcggct?1920

ccaagccttt?ttaacgaaag?tgaaagtaag?gaatctgcct?atcttcaaga?gttgatccat?1980

tttggattta?ggcggagaga?gaagaggatg?aatcacaaag?gactgtctaa?ggaggatatg?2040

gggtcctatc?acagtctttt?gtctagtctg?gttgcctatc?accagcaggg?tgagatgagc?2100

gatactgagc?aagatttgac?ttttgtcaag?gttctgtcgc?gtgtcatagg?taaaaaacta?2160

gatcagcaag?gtctggaaaa?tccagctatc?ccaaccagtc?caagcagcaa?gaccttagcc?2220

aaggacacct?tgcaagctct?ctatcctgcc?aaacaggagt?tttacctgtc?tacgtcgggt?2280

ttgacagagt?tttatcgcaa?tgaatacagt?tatttcctac?gctacgtttt?aggcttgcag?2340

gaggaattac?gtttgcatcc?tgatgcccgt?agtcacggga?atttcttgca?tcgtatcttt?2400

gaacgcgcct?tacagttgcc?taatgaagat?tcctttgacc?aacgtctaga?acaagctatt?2460

caagaaacca?gtcaagaacg?cgaatttgaa?gctatttatc?aagaaagttt?ggaagcccag?2520

tttaccaagg?aagttttgct?tgatgttgca?cggacaactg?gacatattct?ccgacacaat?2580

ccagccatcg?aaaccatcaa?agaagaagca?aattttggtg?gaaaagacca?agcctttatt?2640

caattagaca?atggacgcag?tgtctttgta?cgaggcaagg?tggaccggat?tgaccgtttg?2700

aaagctaatg?gagcgatagg?agtagtagac?tacaaatcca?gtctgactca?gttccagttt?2760

cctcatttct?ttaatgggct?caattctcag?ttaccaacct?atcttgctgc?cctaaaaaga?2820

gaaggggagc?agaacttttt?cggcgccatg?tacttggaaa?tggctgaacc?tgtccaatct?2880

ctgatggcgg?taaaaagtct?ggcaggagca?gtggtagaag?ccagcaaatc?tatgaaatac?2940

caagggctct?tcttggaaaa?agaaagcagt?tatttaggcg?aattttataa?caaaaacaag?3000

gctaatcaac?tgacagatga?ggaatttcag?ctcctactgg?actacaatgc?ctatctttac?3060

aagaaagctg?ctgagaagat?tttagcaggc?cggttcgcca?tcaatcctta?tactgaaaat?3120

ggcagaagca?ttgccccata?cgtccagcaa?catcaggcta?ttacaggctt?tgaagccaat?3180

taccatctgg?gccaagcccg?tttcctagaa?aagttggacc?tagctgatgg?caagcgtctg?3240

gtcggagaaa?aactcaagca?agcttggctt?gaaaaaataa?gagaggagtt?gaatcgatga?3300

<210>220

<211>3651

<212>DNA

＜213〉streptococcus pneumoniae

<400>220

atgaagctta?ttcccttttt?aagtgaggag?gagattcaaa?aactgcaaga?agcagaagca?60

aattcgagca?aggaacagaa?gaaaactgcc?gagcaaatcg?aagctatcta?cacttctgcc?120

cagaatatcc?tggtctcagc?atcggctggt?tctggaaaga?cctttgtcat?ggcagagcgc?180

attctggacc?aattggcgcg?tggtgtcgaa?atttctcaac?tctttatctc?aacctttacc?240

gtcaaggctg?caactgaact?taaagaacgt?ttagagaaaa?aaatcagcaa?gaaaatccaa?300

gaaacagatg?atgtcgacct?caaacaacac?ttgggtcgcc?agttggcaga?cctacccaac?360

gctgccattg?gaaccatgga?ttctttcaca?caaaaattcc?ttggcaaaca?tggttatctg?420

cttgatattg?cacctaattt?ccgtatttta?caaaaccaaa?gcgagcaact?tattctcgaa?480

aacgaagtct?ttcatgaggt?ctttgaagcg?cattaccaag?gtaaacagaa?agagaccttt?540

agtcatttgc?tgaaaaactt?tgctgggcgt?ggcaaggacg?aacggggtct?gcgccagcag?600

gtctataaaa?tctatgactt?cctccaatcc?accagtaatc?ctcaaaagtg?gctgagtgaa?660

tctttcctca?aaggatttga?gaaagctgat?tttaccagtg?aaaaagaaaa?actgaccgag?720

caaatcaaac?aagccctttg?ggatttggaa?agctttttcc?gttaccatct?ggataacgat?780

gccaaggagt?ttgcaaaggc?tgcctattta?gaaaatgttc?agttaattct?ggatgaaatt?840

ggctccctaa?atcaggagtc?cgatagtcag?gcttatcagg?cagtgcttgc?gcgtgttgtc?900

gccatctcta?aggagaaaaa?cggtcgagct?ctgactaatg?ccagccgtaa?ggctgatttg?960

aagcccctgg?ctgatgccta?caacgaagag?agaaagaccc?agtttgctaa?actaggacaa?1020

ttatcagacc?agatagcgat?tctcgactat?caagaacgtt?atcatggaga?cacttggaaa?1080

ctagctaaaa?ccttccaatc?tttcatgagc?gattttgtag?aggcttatcg?tcagagaaaa?1140

cgacaggaaa?atgccttcga?attcgctgat?atcagccatt?acaccattga?gattttagag?1200

aatttcccac?aagttcgtga?gtcttatcag?gagcgcttcc?atgaagtcat?ggtcgatgag?1260

tatcaggata?ccaaccatat?tcaagaacgg?atgctggaat?tgttgtctaa?tggccacaat?1320

cgctttatgg?tgggagatat?caagcaatcc?atctatcgtt?tccgtcaggc?agacccgcag?1380

attttcaatg?agaaattcca?acgctatgcg?caaaatcccc?aagaaggcag?gctcattatc?1440

ctcaaggaaa?atttccgtag?tagttcagaa?gtgctgtcag?caaccaatga?tgtctttgaa?1500

cgtctcatgg?accaagaggt?cggcgaaatc?aactatgata?acaagcacca?gcttgttttt?1560

gccaatacca?aactgactcc?caatccagac?aacaaggcag?catttctcct?ctacgacaag?1620

gacgatacag?gtgaggaaga?agagagtcaa?acagaaacga?aactaacagg?cgaaatgcgc?1680

ttagttatca?aggagattct?gaaacttcat?caagaaaaag?gtgttgcctt?taaggaaatt?1740

gcccttctga?cctccagccg?cagtcgtaat?gaccagattc?tcctcgccct?gtctgagtac?1800

ggaattcctg?tcaaaactga?cggagagcaa?aacaattatc?tccaatccct?agaagtgcaa?1860

gtcatgctag?acactcttcg?tgtcattcac?aatcccctgc?aagactacgc?cttggttgcc?1920

cttatgaagt?ctccaatgtt?tggttttgat?gaggatgagc?tagcacgttt?gtcccttcag?1980

aaagcagagg?ataaagtcca?cgaaaatctc?tatgagaaac?tggtcaatgc?acaaaaaatg?2040

gcaagtagtc?aaaaaggctt?gattcacaca?gctctagctg?aaaaactaaa?gcaattcatg?2100

gatatcctag?cttcttggcg?cttgtatgcc?aaaacccact?ctctctatga?cttgatttgg?2160

aagatttaca?acgaccgttt?ttattatgac?tatgttgggg?ctttgccgaa?tggtcctgct?2220

aggcaggcca?atctctatgc?cctagcactg?cgtgctgatc?aatttgaaaa?gagcaatttc?2280

aaaggtttgt?cgcgttttat?tcgtatgatt?gaccaagtct?tagaagccca?gcacgatttg?2340

gcaagcgtgg?ccgtcgcacc?gccaaaagat?gcagtagagc?tcatgaccat?ccacaagagt?2400

aaagggctgg?agtttcctta?cgtctttatc?ctcaatatgg?atcaagattt?caacaagcaa?2460

gactctatgt?cagaagtcat?tctcagtcgt?cagaatggtc?ttggtgtcaa?atatattgcc?2520

aagatggaga?caggggcagt?agaagaccac?tatcctaaaa?ccatcaaact?ctccattcct?2580

agtctgacct?ataggcagaa?cgaagaggaa?ttacagctag?caagctattc?tgagcagatg?2640

cgtttgctgt?atgttgctat?gacgcgggct?gagaaaaagc?tctatcttgt?cggcaagggt?2700

tctcgtgaaa?agctggaatc?caaggaatac?ccagcagcca?aaaatgggaa?actaaatagc?2760

aatactagac?tgcaagcacg?gaatttccaa?gattggcttt?gggctatcag?taaagtgttt?2820

actaaggaca?agctcaactt?tagttatcgt?tttattggcg?aagatcagtt?gaccagagaa?2880

gctatcggag?agttggaaac?caagagtcct?ctccaagata?gctcccaagc?agacaatcgt?2940

cagtcagata?ccatcaaaga?agctctggaa?atgctgaagg?aggtggaagt?ttataatact?3000

cttcaccgcg?cagctattga?acttcctagt?gttcaaaccc?caagtcaaat?caagaaattc?3060

tacgaaccag?ttatggatat?ggaaggtgtc?gagattgctg?gtcaaggtca?gtcagtaggc?3120

aagaaaatca?gcttcgattt?gccagatttt?tcaaccaaag?aaaaggtaac?tggagctgag?3180

attggtagtg?ctactcacga?actcatgcag?agaattgacc?tcagccagca?actaaccctt?3240

gctagcctaa?cagaaacact?caaacaagtt?caaactagcc?aagctgtcag?agacaagatc?3300

aatcttgata?aaattcttgc?tttctttgac?acagtactcg?gtcaggaaat?tcttgctaat?3360

accgaccatc?tttatcgcga?gcaacctttc?tccatgctca?aacgagacca?aaagagtcag?3420

gaagactttg?ttgtccgtgg?tatccttgat?ggctatctgc?tttacgaaaa?caaaattgtt?3480

ctgttcgact?acaagacaga?ccgctatgat?gaaccaagtc?aactcgtaga?ccgctatcgt?3540

ggtcagttag?ctctatacga?agaggcttta?tcacgagcct?attcgattga?aaatattgaa?3600

aaatacttga?ttttactcgg?taaagacgag?gttcaagttg?taaaagtata?a 3651

<210>221

<211>648

<212>DNA

＜213〉streptococcus pneumoniae

<400>221

atggaacttg?ctcgccatgc?tgaaagcttg?ggagtagatg?ctattgcaac?gattccacca?60

atttatttcc?gcttgccaga?atactcagtt?gccaaatact?ggaacgatat?cagttctgca?120

gctccaaaca?cagactacgt?gatttacaac?attcctcaat?tggcaggggt?tgctttgact?180

ccaagccttt?acacagaaat?gttgaaaaat?cctcgtgtta?tcggtgtgaa?gaactcttct?240

atgccagttc?aagatatcca?aacctttgtc?agccttggtg?gagaagacca?tatcgtcttt?300

aatggtcctg?atgagcagtt?cctaggagga?cgcctcatgg?gggctagggc?tggtatcggt?360

ggtacttatg?gtgctatgcc?agaactcttc?ttgaaactca?atcagttgat?tgcggataag?420

gacctagaaa?cagcgcgtga?attgcagtat?gctatcaacg?caatcattgg?taaactcact?480

tctgctcatg?gaaatatgta?cggtgtcatc?aaagaagtct?tgaaaatcaa?tgaaggcttg?540

aatattggat?ctgttcgttc?accattgaca?ccagtgactg?aagaagatcg?tccagttgta?600

gaagcggctg?ctgccttgat?tcgtgaaacc?aaggagcgct?tcctctaa 648

<210>222

<211>1224

<212>DNA

＜213〉streptococcus pneumoniae

<400>222

atgtataaga?caaagtgttt?acgagagaag?ttagtattat?ttttaaaaat?tttcttccca?60

atcctgatct?accaatttgc?caattattct?gcctcttttg?ttgatactgc?aatgacaggt?120

caatacaaca?ctatggactt?ggctggtgta?tctatggcaa?ccagtatctg?gaatcctttc?180

tttacatttc?taacagggat?tgtgtcagcc?ttggtgccta?tcattggtca?ccatcttggt?240

cgaggcaaaa?aggaagaagt?tgcgtctgat?ttttaccaat?ttatttattt?ggccttgggc?300

ctatctgtgg?tcttgctggg?gatggtactt?ttcttggcac?caataatctt?gaatcatatt?360

gggttagaag?cagcagtagc?ggcagtagcg?gttcgctatc?tttggttttt?atctatcggg?420

attatcccct?tgttgctctt?tagcgtcatt?cgttccttgc?tggattcgct?gggcttgacc?480

aaactgtcca?tgtacctcat?gcttttgtta?ctccctctca?atagcggatt?taactatctc?540

ttgatttacg?gtgcctttgg?tgttccagaa?ctgggagggg?ctggtgctgg?tttaggaaca?600

tccttggcct?actgggtctt?gcttgggatt?tctgttctgg?ttttatttaa?acaggagaag?660

ctcaaagcct?tacaccttga?gaaacgaatt?ccacttaata?tggataaaat?taaggaagga?720

gttcgtttag?gtctgcctat?tgggggaact?gtcttcgcgg?aagtggctat?cttttcagtg?780

gttggcttga?ttatggctaa?gttttcgccc?ttgattatag?ctagtcacca?gtcagctatg?840

aacttttcaa?gtcttatgta?cgcctttcct?atgagtatct?catcggctat?ggctattgtc?900

gtttcctatg?aagtgggagc?caagcgattt?gatgatgcga?aaacctatat?tggtctagga?960

agatggactg?ccctcatttt?tgcggccttc?accttaacct?tcctttacat?ttttagggga?1020

aatgtggcca?gtctttatgg?taacgaccca?aaatttatcg?atttgacagt?gcgtttttta?1080

acttatagtc?ttttcttcca?gttagcagat?acctttgcgg?cgccgcttca?gggaattttg?1140

cgggggtata?aggatacagt?tattcctttt?taccttggtt?tgcttggtta?ttggggcgta?1200

gcaatccctg?tgtacgctat?ttga 1224

<210>223

<211>570

<212>DNA

＜213〉streptococcus pneumoniae

<400>223

atgagtactt?tagcaaaaat?agaagcgctc?ttgtttgtag?cgggtgaaga?tgggattcgg?60

gtccgccagt?tagctgaact?cctctctctg?ccaccgacag?gcatccagca?aagtttagga?120

aaattagccc?agaagtatga?aaaggaccca?gattccagtt?tggctttgat?tgagacaagt?180

ggtgcttata?gattggtgac?caagcctcaa?tttgcagaga?ttttgaagga?atactctaag?240

gcgcctatca?accagagctt?gtctcgggct?gcccttgaga?ccttgtccat?tattgcctac?300

aaacagccga?ttacgcggat?agaaattgat?gccatccgtg?gagttaactc?gagtggagcc?360

ttggcaaagt?tgcaggcttt?tgacctgata?aaggaagacg?ggaaaaagga?agtattgggg?420

cgccccaacc?tctatgtgac?tacggattat?ttcctagatt?acatggggat?aaaccattta?480

gaagaattac?cagtgattga?tgagcttgag?attcaagccc?aagaaagcca?attatttggt?540

gaaaggatag?aagaagatga?gaatcaataa 570

<210>224

<211>936

<212>DNA

＜213〉streptococcus pneumoniae

<400>224

atggatacga?tgattagtag?attttttcgc?catttatttg?aagccttaaa?aagtttgaaa?60

cgaaatggtt?ggatgacagt?agctgctgtc?agttcagtca?tgattacttt?gaccttggtg?120

gcaatatttg?catctgttat?tttcaataca?gcgaaactag?ctacagatat?tgaaaataat?180

gtccgtgtag?tagtttatat?ccgaaaggat?gtggaagata?atagtcagac?aattgaaaaa?240

gaaggtcaaa?ctgttacaaa?taatgactac?cacaaggtat?atgattcttt?gaagaacatg?300

tctacggtta?aaagtgttac?cttttcaagt?aaagaagaac?aatatgaaaa?attaaccgag?360

ataatgggag?ataactggaa?aatctttgaa?ggagatgcca?atcctctcta?tgatgcctat?420

attgtagagg?caaacactcc?aaatgatgta?aaaactatag?ccgaagatgc?taaaaaaatt?480

gaaggtgtct?ctgaggttca?agatggcggt?gccaatacag?aaagactctt?caagttagct?540

tcatttatcc?gtgtttgggg?actagggatt?gctgctttgt?taatttttat?cgcagttttc?600

ttgatttcaa?ataccattcg?tattaccatt?atttcccgca?gtcgcgaaat?tcaaatcatg?660

cgcttggtcg?gagctaaaaa?cagttatatc?cgtggaccgt?tcttgttaga?aggagccttt?720

atcggtttat?tgggagctat?cgcaccatct?gttttggtct?ttattgttta?tcaaattgtt?780

taccaatctg?tcaacaaatc?gttggtaggg?caaaatctat?ccatgattag?tccagattta?840

tttagtccgt?tgatgattgc?cctactattt?gtgattgggg?ttttcattgg?ttcattggga?900

tcaggaatat?ccatgcgccg?attcttgaag?atttag 936

<210>225

<211>1977

<212>DNA

＜213〉streptococcus pneumoniae

<400>225

atgaagaaag?taagatttat?ttttttagct?ctgctatttt?tcttagctag?tccagagggt?60

gcaatggcta?gtgatggtac?ttggcaagga?aaacagtatc?tgaaagaaga?tggcagtcaa?120

gcagcaaatg?agtgggtttt?tgatactcat?tatcaatctt?ggttctatat?aaaagcagat?180

gctaactatg?ctgaaaatga?atggctaaag?caaggtgacg?actattttta?cctcaaatct?240

ggtggctata?tggccaaatc?agaatgggta?gaagacaagg?gagcctttta?ttatcttgac?300

caagatggaa?agatgaaaag?aaatgcttgg?gtaggaactt?cctatgttgg?tgcaacaggt?360

gccaaagtaa?tagaagactg?ggtctatgat?tctcaatacg?atgcttggtt?ttatatcaaa?420

gcagatggac?agcacgcaga?gaaagaatgg?ctccaaatta?aagggaagga?ctattatttc?480

aaatccggtg?gttatctact?gacaagtcag?tggattaatc?aagcttatgt?gaatgctagt?540

ggtgccaaag?tacagcaagg?ttggcttttt?gacaaacaat?accaatcttg?gttttacatc?600

aaagaaaatg?gaaactatgc?tgataaagaa?tggattttcg?agaatggtca?ctattattat?660

ctaaaatccg?gtggctacat?ggcagccaat?gaatggattt?gggataagga?atcttggttt?720

tatctcaaat?ttgatgggaa?aatggctgaa?aaagaatggg?tctacgattc?tcatagtcaa?780

gcttggtact?acttcaaatc?cggtggttac?atgacagcca?atgaatggat?ttgggataag?840

gaatcttggt?tttatctcaa?atctgatggg?aaaatagctg?aaaaagaatg?ggtctacgat?900

tctcatagtc?aagcttggta?ctacttcaaa?tccggtggtt?acatgacagc?caatgaatgg?960

atttgggata?aggaatcttg?gttttacctc?aaatctgatg?ggaaaatagc?tgaaaaagaa?1020

tgggtctacg?attctcatag?tcaagcttgg?tactacttca?aatctggtgg?ctacatggcg?1080

aaaaatgaga?cagtagatgg?ttatcagctt?ggaagcgatg?gtaaatggct?tggaggaaaa?1140

actacaaatg?aaaatgctgc?ttactatcaa?gtagtgcctg?ttacagccaa?tgtttatgat?1200

tcagatggtg?aaaagctttc?ctatatatcg?caaggtagtg?tcgtatggct?agataaggat?1260

agaaaaagtg?atgacaagcg?cttggctatt?actatttctg?gtttgtcagg?ctatatgaaa?1320

acagaagatt?tacaagcgct?agatgctagt?aaggacttta?tcccttatta?tgagagtgat?1380

ggccaccgtt?tttatcacta?tgtggctcag?aatgctagta?tcccagtagc?ttctcatctt?1440

tctgatatgg?aagtaggcaa?gaaatattat?tcggcagatg?gcctgcattt?tgatggtttt?1500

aagcttgaga?atcccttcct?tttcaaagat?ttaacagagg?ctacaaacta?cagtgctgaa?1560

gaattggata?aggtatttag?tttgctaaac?attaacaata?gccttttgga?gaacaagggc?1620

gctactttta?aggaagccga?agaacattac?catatcaatg?ctctttatct?ccttgcccat?1680

agtgccctag?aaagtaactg?gggaagaagt?aaaattgcca?aagataagaa?taatttcttt?1740

ggcattacag?cctatgatac?gaccccttac?ctttctgcta?agacatttga?tgatgtggat?1800

aagggaattt?taggtgcaac?caagtggatt?aaggaaaatt?atatcgatag?gggaagaact?1860

ttccttggaa?acaaggcttc?tggtatgaat?gtggaatatg?cttcagaccc?ttattggggc?1920

gaaaaaattg?ctagtgtgat?gatgaaaatc?aatgagaagc?taggtggcaa?agattag 1977

<210>226

<211>867

<212>DNA

＜213〉streptococcus pneumoniae

<400>226

atgaaaaaag?tattacaaaa?atattgggca?tgggcttttg?tggtcatccc?cctcttgtta?60

caagcaattt?tcttctatgt?gccgatgttt?caaggagcct?tttacagttt?taccaactgg?120

acaggattga?cttataacta?caaatttgtt?ggcttaaaca?actttaagct?cctcttcatg?180

gatccaaaat?tcatgaatgc?gattggcttt?accgcaatca?ttgcgattgc?catggtggtt?240

ggtgagattg?cactcgggat?cttcattgcg?cgtgtcttga?attctaaaat?caaaggccaa?300

accttcttcc?gtgcttggtt?cttcttccca?gctgttttat?ctggtttgac?agtggctttg?360

atcttcaagc?aagtcttcaa?ctacggtctt?ccagcgattg?gaaatgccct?tcatattgaa?420

tttttccaaa?ccagtctttt?agggactaag?tggggagcaa?tctttgcggc?tgtctttgtc?480

cttctttggc?aaggggtggc?tatgcccatc?atcatcttcc?tagctggttt?gcaatctatt?540

ccaactgaga?ttacagaggc?agcaaggatt?gatggtgcga?ctagcaagca?agttttctgg?600

aacattgaat?tgccttactt?gctaccaagt?gtctctatgg?tctttatcct?agccctaaaa?660

ggtgggctga?ctgcctttga?ccaagtcttt?gccatgaccg?gtggtggtcc?aaacaatgcc?720

acaacctcac?ttgggctctt?ggtttataac?tatgccttta?aaaacaacca?attcggttat?780

gccaatgcca?ttgccgtaat?cttgttcttc?ttaattgtag?tgatttcgat?catccaattg?840

agagtatcta?agaaatttga?aatttaa 867

<210>227

<211>837

<212>DNA

＜213〉streptococcus pneumoniae

<400>227

atgatgaaac?aagatgaaag?aaaagccctg?attggcaaat?acattctatt?gattctagga?60

tcggttctga?ttttagtgcc?gctccttgct?accctcttta?gttccttcaa?acccactaag?120

gatattgtag?ataatttctt?tggctttcca?accaacttca?catgggacaa?ctttagccgt?180

ctcttagctg?atgggattgg?aggctattat?tggaactctg?tcgtcatcac?tgtcttgtct?240

ttacttgcag?taatgatctt?tatccctatg?gcagcctact?ccatcgctcg?caatatgagt?300

aaaagaaaag?cctttaccat?catgtatacc?ctcttaatcc?tcggaatctt?cgtacctttc?360

caagtcatca?tgattccgat?tacggttatg?atgagtaaac?tcggtttggc?taataccttt?420

ggtttgatct?tgctctactt?gacctatgcg?attccacaga?ccctctttct?ctatgttggc?480

tatatcaaaa?tctcgattcc?agaaagtctg?gatgaagcag?cagagatcga?tggggctaat?540

caatttacaa?cctatttccg?catcatcttc?ccaatgatga?aaccgatgca?tgcgacaacc?600

atgatcatca?atgccctttg?gttctggaat?gacttcatgt?tgccactcct?tgtcttgaac?660

cgggattcca?aaatgtggac?tctgcctttg?ttccaataca?actacgcagg?ccaatatttc?720

aacgactacg?gaccaagctt?tgcctcttac?gtggtcggca?ttatcagtat?caccattgtc?780

tatctcttct?tccaacgcca?tatcatttca?ggaatgagca?acggggcagt?gaagtaa 837

<210>228

<211>1044

<212>DNA

＜213〉streptococcus pneumoniae

<400>228

atgaaaagta?ttcttcagaa?aatgggggag?catccgatgc?tgcttctttt?tcttagctat?60

agtactgtta?tatccattct?tgcacaaaat?tggatgggtc?ttgtggcttc?agtaggaatg?120

tttctattta?ctattttctt?tttgcactat?cagtcgattt?tatcccataa?attctttcga?180

ttgattttgc?agtttgtctt?gtttggtagt?gtcttgtcag?ctgcttttgc?cagtttagaa?240

catttccaaa?ttgtgaagaa?atttaactat?gcttttcttt?cacccaatat?gcaggtgtgg?300

catcagaacc?gggcagaagt?gaccttcttt?aatcctaatt?attatggaat?tatttgttgt?360

ttctgtatta?tgattgcttt?ctatctgttt?acaacgacca?agttgaattg?gttgaaagta?420

ttctgtgtga?ttgcaggctt?tgttaatctc?tttggtttga?actttactca?aaatcgaact?480

gcctttcctg?ctattatcgc?tggagcaatt?atctatctct?ttacgactat?taaaaactgg?540

aaggcctttt?ggcttagtat?tggggtcttc?gcgattggtt?tgagtttcct?cttttctagt?600

gatttgggag?ttcgaatggg?tactttagac?tcttctatgg?aagaacgcat?ttctatctgg?660

gatgctggga?tggccttgtt?taagcaaaat?cctttttggg?gtgaagggcc?attgacctat?720

atgaactctt?atcctcggat?acatgctcct?tatcatgaac?atgcccacag?tctttatatt?780

gatacgattc?tgagttacgg?aattgtgggg?actattttat?tagttttgtc?ttctgttgct?840

cctgttcgct?tgatgatgga?tatgagtcag?gagtcgggga?aacgtccgat?tatcggcctt?900

tatctatctt?tccttacagt?ggttgctgtg?cacggaattt?ttgacttggc?tctcttctgg?960

attcagtcag?gctttatttt?cttgctagtt?atgtgcagta?ttccattgga?gcatcgaatg?1020

ttggtatcgg?acatgacgga?ttaa 1044

<210>229

<211>1299

<212>DNA

＜213〉streptococcus pneumoniae

<400>229

atgtcaaaga?tggatgttca?gaaaatcatt?gcaccgatga?tgaagtttgt?gaatatgcgt?60

ggcattatag?ctctaaaaga?tgggatgtta?gcaattttgc?cattgacagt?agttggtagt?120

ttgttcttga?ttatgggaca?attgccgttc?gaaggattaa?ataagagcat?tgctagtgtt?180

tttggagcta?attggacaga?gccgtttatg?caagtatatt?caggaacttt?tgctattatg?240

ggtctaattt?cttgtttttc?aattgcctat?tcttatgcta?agaatagcgg?agtagaggct?300

ttaccagctg?gagttctatc?tgtatctgca?ttctttattt?tgctaagatc?atcttatatc?360

cctaaacaag?gtgaggcgat?tggggacgct?attagtaaag?tttggtttgg?aggccaagga?420

attatcggtg?ctatcattat?aggtttggta?gtaggaagta?tttatacctt?ctttataaag?480

agaaaaattg?ttattaagat?gccagaacaa?gttccacaag?ctattgccaa?acagtttgaa?540

gcaatgattc?cagcatttgt?aattttctta?tcttctatga?ttgtatatat?tttagcgaag?600

tcattgacta?atggcggaac?attcatagaa?atgatttatt?ctgctattca?agttccgttg?660

caaggtttaa?ctggatcttt?gtatggtgct?attggaattg?cattctttat?atcatttttg?720

tggtggtttg?gtgttcatgg?gcaatcggta?gtaaatggag?tagtgacagc?tctgctttta?780

tctaatcttg?atgctaataa?agctatgtta?gcctctgcta?atctatcatt?agaaaatggt?840

gcacatattg?ttactcaaca?atttttagat?tcatttttaa?ttctatcagg?ttcagggatt?900

acgtttggtc?ttgtagttgc?catgcttttt?gcagcaaaat?caaaacaata?ccaagcctta?960

ggaaaagttg?cagcttttcc?agcaatattt?aacgtaaatg?agccagttgt?atttggattt?1020

ccgattgtca?tgaatccagt?tatgtttgta?cctttcattc?ttgttcctgt?acttgcagct?1080

gtgatagtat?atggagctat?tgcaacaggt?ttcatgcagc?cattctcagg?ggtaacattg?1140

ccttggagta?caccagctat?tttatcagga?tttttggtgg?gtggatggca?aggagttatt?1200

actcagctgg?tgatattagc?gatgtctaca?ttggtttatt?ttccattctt?taaagtacag?1260

gatcgtttag?cttaccaaaa?tgaaatcaaa?caatcttag 1299

<210>230

<211>303

<212>DNA

＜213〉streptococcus pneumoniae

<400>230

atgaagaaaa?aggacttagt?agaccaacta?gtctcagaga?tcgagacggg?gaaagtcagg?60

acactgggaa?tatacggtca?tggagcttca?ggtaaatcaa?cctttgcaca?ggaattgtac?120

caagctttag?attctactac?agtaaatttg?ctagagacag?atccttatat?cacctcagga?180

cgccatctgg?tagtacccaa?ggacgcgccg?aatcaaaagg?tgacagccag?tctgccagtg?240

gcgcatgaac?tggagagttt?gcagagagat?atccttgctt?gcaggcgggt?atggatgtct?300

tga 303

<210>231

<211>717

<212>DNA

＜213〉streptococcus pneumoniae

<400>231

atgaagaaaa?gatacctagt?cttgacagct?ttgctagcct?tgagtctagc?agcttgttca?60

caagaaaaaa?caaaaaatga?agatggagaa?actaagacag?aacagacagc?caaagctgat?120

ggaacagtcg?gtagtaagtc?tcaaggagct?gcccagaaga?aagcagaagt?ggtcaataaa?180

ggtgattact?acagcattca?agggaaatac?gatgaaatca?tcgtagccaa?caaacactat?240

ccattgtcta?aagactataa?tccaggggaa?aatccaacag?ccaaggcaga?gttggtcaaa?300

ctcatcaaag?cgatgcaaga?ggcaggtttc?cctattagtg?atcattacag?tggttttaga?360

agttatgaaa?ctcagaccaa?gctctatcaa?gattatgtca?accaagatgg?aaaggcagca?420

gctgaccgtt?actctgcccg?tcctggctat?agcgaacacc?agacaggctt?ggcctttgat?480

gtgattggga?ctgatggtga?tttggtgaca?gaagaaaaag?cagcccaatg?gctcttggat?540

catgcagctg?attatggctt?tgttgtccgt?tatctcaaag?gcaaggaaaa?ggaaacaggc?600

tatatggctg?aagaatggca?cctgcgttat?gtaggaaaag?aagctaaaga?aattgctgca?660

agtggtctca?gtttggaaga?atactatggc?tttgaaggcg?gagactacgt?cgattaa 717

<210>232

<211>1269

<212>DNA

＜213〉streptococcus pneumoniae

<400>232

atgcgtaaat?tcttaattat?tttgttgcta?ccaagttttt?tgaccatttc?aaaagtcgtt?60

agcacagaaa?aagaagtcgt?ctatacttcg?aaagaaattt?attacctttc?acaatctgac?120

tttggtattt?attttagaga?aaaattaagt?tctcccatgg?tttatggaga?ggttcctgtt?180

tatgcgaatg?aagatttagt?agtggaatct?gggaaattga?ctcccaaaac?aagttttcaa?240

ataaccgagt?ggcgcttaaa?taaacaagga?attccagtat?ttaagctatc?aaatcatcaa?300

tttatagctg?cggacaaacg?atttttatat?gatcaatcag?aggtaactcc?aacaataaaa?360

aaagtatggt?tagaatctga?ctttaaactg?tacaatagtc?cttatgattt?aaaagaagtg?420

aaatcatcct?tatcagctta?ttcgcaagta?tcaatcgaca?agaccatgtt?tgtagaagga?480

agagaatttc?tacatattga?tcaggctgga?tgggtagcta?aagaatcaac?ttctgaagaa?540

gataatcgga?tgagtaaagt?tcaagaaatg?ttatctgaaa?aatatcagaa?agattctttc?600

tctatttatg?ttaagcaact?gactactgga?aaagaagctg?gtatcaatca?agatgaaaag?660

atgtatgcag?ccagcgtttt?gaaactctct?tatctctatt?atacgcaaga?aaaaataaat?720

gagggtcttt?atcagttaga?tacgactgta?aaatacgtat?ctgcagtcaa?tgattttcca?780

ggttcttata?aaccagaggg?aagtggtagt?cttcctaaaa?aagaagataa?taaagaatat?840

tctttaaagg?atttaattac?gaaagtatca?aaagaatctg?ataatgtagc?tcataatcta?900

ttgggatatt?acatttcaaa?ccaatctgat?gccacattca?aatccaagat?gtctgccatt?960

atgggagatg?attgggatcc?aaaagaaaaa?ttgatttctt?ctaagatggc?cgggaagttt?1020

atggaagcta?tttataatca?aaatggattt?gtgctagagt?ctttgactaa?aacagatttt?1080

gatagtcagc?gaattgccaa?aggtgtttct?gttaaagtag?ctcataaaat?tggagatgcg?1140

gatgaattta?agcatgatac?gggtgttgtc?tatgcagatt?ctccatttat?tctttctatt?1200

ttcactaaga?attctgatta?tgatacgatt?tctaagatag?ccaaggatgt?ttatgaggtt?1260

ctaaaatga 1269

<210>233

<211>1959

<212>DNA

＜213〉streptococcus pneumoniae

<400>233

atgaaaaaac?aaaataatgg?tttaattaaa?aatccttttc?tatggttatt?atttatcttt?60

ttccttgtga?caggattcca?gtatttctat?tctgggaata?actcaggagg?aagtcagcaa?120

atcaactata?ctgagttggt?acaagaaatt?accgatggta?atgtaaaaga?attaacttac?180

caaccaaatg?gtagtgttat?cgaagtttct?ggtgtctata?aaaatcctaa?aacaagtaaa?240

gaagaaacag?gtattcagtt?tttcacgcca?tctgttacta?aggtagagaa?atttaccagc?300

actattcttc?ctgcagatac?taccgtatca?gaattgcaaa?aacttgctac?tgaccataaa?360

gcagaagtaa?ctgttaagca?tgaaagttca?agtggtatat?ggattaatct?actcgtatcc?420

attgtgccat?ttggaattct?attcttcttc?ctattctcta?tgatgggaaa?tatgggagga?480

ggcaatggcc?gtaatccaat?gagttttgga?cgtagtaagg?ctaaagcagc?aaataaagaa?540

gatattaaag?taagattttc?agatgttgct?ggagctgagg?aagaaaaaca?agaactagtt?600

gaagttgttg?agttcttaaa?agatccaaaa?cgattcacaa?aacttggagc?ccgtattcca?660

gcaggtgttc?ttttggaggg?acctccgggg?acaggtaaaa?ctttgcttgc?taaggcagtc?720

gctggagaag?caggtgttcc?attctttagt?atctcaggtt?ctgactttgt?agaaatgttt?780

gtcggagttg?gagctagtcg?tgttcgctct?ctttttgagg?atgccaaaaa?agcagcacca?840

gctatcatct?ttatcgatga?aattgatgct?gttggacgtc?aacgtggagt?cggtctcggc?900

ggaggtaatg?acgaacgtga?acaaaccttg?aaccaacttt?tgattgagat?ggatggtttt?960

gagggaaatg?aagggattat?cgtcatcgct?gcgacaaacc?gttcagatgt?acttgaccct?1020

gcccttttgc?gtccaggacg?ttttgataga?aaagtattgg?ttggtcgtcc?tgatgttaaa?1080

ggtcgtgaag?caatcttgaa?agttcacgct?aagaataagc?ctttagcaga?agatgttgat?1140

ttgaaattag?tggctcaaca?aactccaggc?tttgttggtg?ctgatttaga?gaatgtcttg?1200

aatgaagcag?ctttagttgc?tgctcgtcgc?aataaatcga?taattgatgc?ttcagatatt?1260

gatgaagcag?aagatagagt?tattgctgga?ccttctaaga?aagataagac?agtttcacaa?1320

aaagaacgag?aattggttgc?ttaccatgag?gcaggacata?ccattgttgg?tctagtcttg?1380

tcgaatgctc?gcgttgtcca?taaggttaca?attgtaccac?gcggccgtgc?aggcggatac?1440

atgattgcac?ttcctaaaga?ggatcaaatg?cttctatcta?aagaagatat?gaaagagcaa?1500

ttggctggct?taatgggtgg?acgtgtagct?gaagaaatta?tctttaatgt?ccaaaccaca?1560

ggagcttcaa?acgactttga?acaagcgaca?caaatggcac?gtgcaatggt?tacagagtac?1620

ggtatgagtg?aaaaacttgg?cccagtacaa?tatgaaggaa?accatgctat?gcttggtgca?1680

cagagtcctc?aaaaatcaat?ttcagaacaa?acagcttatg?aaattgatga?agaggttcgt?1740

tcattattaa?atgaggcacg?aaataaagct?gctgaaatta?ttcagtcaaa?tcgtgaaact?1800

cacaagttaa?ttgcagaagc?attattgaaa?tacgaaacat?tggatagtac?acaaattaaa?1860

gctctttacg?aaacaggaaa?gatgcctgaa?gcagtagaag?aggaatctca?tgcactatcc?1920

tatgatgaag?taaagtcaaa?aatgaatgac?gaaaaataa 1959

<210>234

<211>1278

<212>DNA

＜213〉streptococcus pneumoniae

<400>234

atgagggaac?cagatttttt?aaatcatttt?ctcaagaagg?gatatttcaa?aaagcatgct?60

aaggcggttc?tagctctttc?tggtggatta?gattccatgt?ttctatttaa?ggtattgtct?120

acttatcaaa?aagagttaga?gattgaattg?attctagctc?atgtgaatca?taagcagaga?180

attgaatcag?attgggaaga?aaaggaatta?aggaagttgg?ctgctgaagc?agagcttcct?240

atttatatca?gcaatttttc?aggagaattt?tcagaagcgc?gtgcacgaaa?ttttcgttat?300

gatttttttc?aagaggtcat?gaaaaagaca?ggtgcgacag?ctttagtcac?tgcccaccat?360

gctgatgatc?aggtggaaac?gatttttatg?cgcttgattc?gaggaactcg?cttgcgctat?420

ctatcaggaa?ttaaggagaa?gcaagtagtc?ggagagatag?aaatcattcg?tcccttcttg?480

cattttcaga?aaaaagactt?tccatcaatt?tttcactttg?aagatacatc?aaatcaggag?540

aatcattatt?ttcgaaatcg?tattcgaaat?tcttacttac?cagaattgga?aaaagaaaat?600

cctcgattta?gggatgcaat?cttaggcatt?ggcaatgaaa?ttttagatta?tgatttggca?660

atagctgaat?tatctaacaa?tattaatgtg?gaagatttac?agcagttatt?ttcttactct?720

gagtctacac?aaagagtttt?acttcaaact?tatctgaatc?gttttccaga?tttgaatctt?780

acaaaagctc?agtttgctga?agttcagcag?attttaaaat?ctaaaagcca?gtatcgtcat?840

ccgattaaaa?atggctatga?attgataaaa?gagtaccaac?agtttcagat?ttgtaaaatc?900

agtccgcagg?ctgatgaaaa?ggaagatgaa?cttgtgttac?actatcaaaa?tcaggtagct?960

tatcaaggat?atttattttc?ttttggactt?ccattagaag?gtgaattaat?tcaacaaata?1020

cctgtttcac?gtgaaacatc?catacacatt?cgtcatcgaa?aaacaggaga?tgttttgatt?1080

aaaaatgggc?atagaaaaaa?actcagacgt?ttatttattg?atttgaaaat?ccctatggaa?1140

aagagaaact?ctgctcttat?tattgagcaa?tttggtgaaa?ttgtctcaat?tttgggaatt?1200

gcgaccaata?atttgagtaa?aaaaacgaaa?aatgatataa?tgaacactgt?actttatata?1260

gaaaaaatag?ataggtaa 1278

<210>235

<211>1692

<212>DNA

＜213〉streptococcus pneumoniae

<400>235

atgaagcgtt?cttctctttt?agttagaatg?gttatttcca?tctttctggt?ctttctcatt?60

ctcctagctc?tggttggaac?tttctactat?caatcaagtt?cttcagccat?tgaggccacc?120

attgagggca?acagccaaac?gaccatcagc?cagactagcc?actttattca?gtcttatatc?180

aaaaaactag?aaaccacctc?gactggtttg?acccagcaga?cggatgttct?ggcctatgct?240

gagaatccca?gtcaagacaa?ggtcgaggga?atccgagatt?tgtttttgac?catcttgaag?300

tcagataagg?acttgaaaac?tgttgtgctg?gtgaccaaat?ctggtcaggt?catttctaca?360

gatgacagtg?tgcagatgaa?aacttcctct?gatatgatgg?ctgaggattg?gtaccaaaag?420

gccattcatc?agggagctat?gcctgttttg?actccagctc?gtaaatcaga?tagtcagtgg?480

gtcatttctg?tcactcaaga?acttgttgat?gcaaagggag?ccaatcttgg?tgtgcttcgt?540

ttggatattt?cttatgaaac?tctggaagcc?tatctcaatc?aactccagtt?ggggcagcag?600

ggctttgcct?tcattatcaa?tgaaaaccat?gaatttgtct?accatcctca?acacacagtt?660

tatagttcgt?ctagcaaaat?ggaggctatg?aaaccctaca?tcgatacagg?tcagggttat?720

actcctggtc?acaaatccta?cgtcagtcaa?gagaagattg?caggaactga?ttggacggtg?780

cttggcgtgt?catcattgga?aaagttagac?caggttcgga?gtcagctctt?gtggaccttg?840

cttggggcca?gtgtcacatc?tcttcttgtc?tgtctctgct?tagtgtggtt?cagtcttaaa?900

cgctggattg?ctcctttgaa?ggatttgaga?gaaaccatgt?tggaaattgc?ttctggtgct?960

caaaatcttc?gtgccaagga?agttggtgcc?tatgaactga?gagaagtaac?tcgccaattt?1020

aatgctatgt?tggatcagat?tgatcagttg?atggtagcta?ttcgtagcca?ggaagaaacg?1080

acccgtcagt?accaacttca?agccctttcg?agccagatta?atccacattt?cctctataac?1140

actttggaca?ccatcatctg?gatggctgaa?tttcatgata?gtcagcgagt?ggtgcaggtg?1200

accaagtcct?tggcaaccta?tttccgcttg?gcgctcaatc?aaggcaagga?cttgatttgt?1260

ctctctgacg?aaatcaatca?tgtccgccag?tatctcttta?tccagaaaca?acgctatgga?1320

gataagctgg?aatacgaaat?taatgaaaat?gttgcctttg?ataatttagt?cttacccaag?1380

ctggtcctac?aaccccttgt?agaaaatgct?ctttaccatg?gcattaagga?aaaggaaggt?1440

cagggccata?ttaaactttc?tgtccagaaa?caggattcgg?gattggtcat?ccgtattgag?1500

gatgatggcg?ttggcttcca?agatgctggt?gatagtagtc?aaagtcaact?caaacgtggg?1560

ggagttggtc?ttcaaaatgt?cgatcaacgg?ctcaaacttc?attttggagc?caattaccat?1620

atgaagattg?attctagacc?ccaaaaaggg?acgaaagttg?aaatatatat?aaatagaata?1680

gaaactagct?aa 1692

<210>236

<211>1692

<212>DNA

＜213〉streptococcus pneumoniae

<400>236

atgaagcgtt?cttctctttt?agttagaatg?gttatttcca?tctttctggt?ctttctcatt?60

ctcctagctc?tggttggaac?tttctactat?caatcaagtt?cttcagccat?tgaggccacc?120

attgagggca?acagccaaac?gaccatcagc?cagactagcc?actttattca?gtcttatatc?180

aaaaaactag?aaaccacctc?gactggtttg?acccagcaga?cggatgttct?ggcctatgct?240

gagaatccca?gtcaagacaa?ggtcgaggga?atccgagatt?tgtttttgac?catcttgaag?300

tcagataagg?acttgaaaac?tgttgtgctg?gtgaccaaat?ctggtcaggt?catttctaca?360

gatgacagtg?tgcagatgaa?aacttcctct?gatatgatgg?ctgaggattg?gtaccaaaag?420

gccattcatc?agggagctat?gcctgttttg?actccagctc?gtaaatcaga?tagtcagtgg?480

gtcatttctg?tcactcaaga?acttgttgat?gcaaagggag?ccaatcttgg?tgtgcttcgt?540

ttggatattt?cttatgaaac?tctggaagcc?tatctcaatc?aactccagtt?ggggcagcag?600

ggctttgcct?tcattatcaa?tgaaaaccat?gaatttgtct?accatcctca?acacacagtt?660

tatagttcgt?ctagcaaaat?ggaggctatg?aaaccctaca?tcgatacagg?tcagggttat?720

actcctggtc?acaaatccta?cgtcagtcaa?gagaagattg?caggaactga?ttggacggtg?780

cttggcgtgt?catcattgga?aaagttagac?caggttcgga?gtcagctctt?gtggaccttg?840

cttggggcca?gtgtcacatc?tcttcttgtc?tgtctctgct?tagtgtggtt?cagtcttaaa?900

cgctggattg?ctcctttgaa?ggatttgaga?gaaaccatgt?tggaaattgc?ttctggtgct?960

caaaatcttc?gtgccaagga?agttggtgcc?tatgaactga?gagaagtaac?tcgccaattt?1020

aatgctatgt?tggatcagat?tgatcagttg?atggtagcta?ttcgtagcca?ggaagaaacg?1080

acccgtcagt?accaacttca?agccctttcg?agccagatta?atccacattt?cctctataac?1140

actttggaca?ccatcatctg?gatggctgaa?tttcatgata?gtcagcgagt?ggtgcaggtg?1200

accaagtcct?tggcaaccta?tttccgcttg?gcgctcaatc?aaggcaagga?cttgatttgt?1260

ctctctgacg?aaatcaatca?tgtccgccag?tatctcttta?tccagaaaca?acgctatgga?1320

gataagctgg?aatacgaaat?taatgaaaat?gttgcctttg?ataatttagt?cttacccaag?1380

ctggtcctac?aaccccttgt?agaaaatgct?ctttaccatg?gcattaagga?aaaggaaggt?1440

cagggccata?ttaaactttc?tgtccagaaa?caggattcgg?gattggtcat?ccgtattgag?1500

gatgatggcg?ttggcttcca?agatgctggt?gatagtagtc?aaagtcaact?caaacgtggg?1560

ggagttggtc?ttcaaaatgt?cgatcaacgg?ctcaaacttc?attttggagc?caattaccat?1620

atgaagattg?attctagacc?ccaaaaaggg?acgaaagttg?aaatatatat?aaatagaata?1680

gaaactagct?aa 1692

<210>237

<211>1140

<212>DNA

＜213〉streptococcus pneumoniae

<400>237

atgtttttta?aattattaag?agaagctctt?aaagtcaagc?aggttcgatc?aaaaatttta?60

tttacaattt?ttatcgtttt?ggtctttcgt?atcggaacta?gcattacagt?tcctggtgtg?120

aatgccaata?gcttgaatgc?tttaagtgga?ttatccttct?taaacatgtt?gagcttggtg?180

tcggggaatg?ccctaaaaaa?cttttcgatt?tttgccctag?gagttagtcc?ctatatcacc?240

gcttctattg?ttgtccaact?cttgcaaatg?gatattttac?ccaagtttgt?agagtggggt?300

aaacaagggg?aagtaggtcg?aagaaaattg?aatcaagcta?ctcgttatat?tgctctagtt?360

ctcgcttttg?tgcaatctat?cgggattaca?gctggtttta?ataccttggc?tggagctcaa?420

ttgattaaaa?ctgctttaac?tccacaagtt?tttctgacga?ttggtatcat?cttaacagct?480

ggtagtatga?ttgtcacttg?gttgggtgag?caaattacag?ataagggata?cggaaacggt?540

gtttccatga?ttatctttgc?cgggattgtt?tcctcaattc?cagagatgat?tcagggcatc?600

tatgtggact?actttgtgaa?cgtcccaagt?agccgtatca?cttcatctat?cattttcgta?660

atcattttga?ttattactgt?attgttgatt?atttacttta?caacttatgt?tcaacaagca?720

gaatacaaaa?ttccaatcca?atatactaag?gttgcacaag?gtgctccatc?tagctcttac?780

cttccgttaa?aagtaaaccc?tgctggagtt?atccctgtta?tctttgccag?ttcgattact?840

gcagcgcctg?cggctattct?tcagtttttg?agtgccacag?gtcatgattg?ggcttgggta?900

agggtagcac?aagagatgtt?ggcaactact?tctccaactg?gtattgccat?gtatgctttg?960

ttgattattc?tctttacatt?cttctatacg?tttgtacaga?ttaatcctga?aaaagcagca?1020

gagacctaca?aaagagtggt?gcctatatcc?atggagttcg?tcctggtaaa?ggtacagaag?1080

aatatatgtc?taaacttctt?cgtcgtcttg?caactgttgg?ttccctcttc?cttggtgtga?1140

<210>238

<211>1338

<212>DNA

＜213〉streptococcus pneumoniae

<400>238

atggatatta?gacaagttac?tgaaaccatc?gccatgattg?aggagcaaaa?cttcgatatt?60

agaaccatta?ccatggggat?ttctcttttg?gactgtatcg?atccagatat?caatcgtgct?120

gcggagaaaa?tctatcaaaa?aattacgaca?aaggcggcta?atttagtagc?tgttggtgat?180

gaaattgcgg?ctgagttggg?aattcctatc?gttaataagc?gtgtatcggt?gacacctatt?240

tctctgattg?gggcagcgac?agatgcgacg?gactacgtgg?ttctggcaaa?agcgcttgat?300

aaggctgcga?aagagattgg?tgtggacttt?attggtggtt?tttctgcctt?agtacaaaaa?360

ggttatcaaa?agggagatga?gattctcatc?aattccattc?ctcgcgcttt?ggctgagacg?420

gataaggtct?gctcgtcagt?caatatcggc?tcaaccaagt?ctggtattaa?tatgacggct?480

gtggcagata?tgggacgaat?tatcaaggaa?acagcaaatc?tttcagatat?gggagtggcc?540

aagttggttg?tattcgctaa?tgctgttgag?gacaatccat?ttatggcggg?tgcctttcat?600

ggtgttgggg?aagcagatgt?tatcatcaat?gtcggagttt?ctggtcctgg?tgttgtgaaa?660

cgtgctttgg?aaaaagttcg?tggacagagc?tttgatgtag?tagccgaaac?agttaagaaa?720

actgccttta?aaatcactcg?tatcggtcaa?ttggttggtc?aaatggccag?tgagagactg?780

ggtgtggagt?ttggtattgt?ggacttgagt?ttggcaccaa?cccctgcggt?tggagactct?840

gtggcacgtg?tccttgagga?aatggggcta?gaaacagttg?gcacgcatgg?aacgacggct?900

gccttggccc?tcttgaacga?ccaagttaaa?aagggtggag?tgatggcctg?caaccaagtc?960

ggtggtttat?ctggtgcctt?tatccctgtt?tctgaggatg?aaggaatgat?tgctgcagtg?1020

caaaatggct?ctcttaattt?agaaaaacta?gaagctatga?cggctatctg?ttctgttgga?1080

ttggatatga?ttgccatccc?agaagatacg?cctgctgaaa?ctattgcggc?tatgattgcg?1140

gatgaagcag?caatcggtgt?tatcaacatg?aaaacaacag?ctgttcgtat?cattcccaaa?1200

ggaaaagaag?gcgatatgat?tgagtttggt?ggtctattag?gaactgcacc?cgttatgaag?1260

gttaatgggg?cttcgtctgt?cgacttcatc?tctcgcggtg?gacaaatccc?agcaccaatt?1320

catagtttta?aaaattaa 1338

<210>239

<211>858

<212>DNA

＜213〉streptococcus pneumoniae

<400>239

atgacacaga?ttattgatgg?gaaagcttta?gcggccaaat?tgcaggggca?gttggctgaa?60

aagactgcaa?aattaaagga?agaaacaggt?ctagtgcctg?gtttggtagt?gattttggtt?120

ggggacaatc?cagccagcca?agtctacgtt?cgcaacaagg?agaggtcagc?ccttgcggct?180

ggtttccgta?gcgaagtagt?acgggttcca?gagaccatta?ctcaagagga?attgttagac?240

ctgattgcta?aatacaatca?ggatccagct?tggcatggga?ttttggttca?gttgccatta?300

ccaaaacaca?ttgatgaaga?ggcggttcta?ttggctattg?acccagaaaa?ggatgtggat?360

ggtttccatc?ctctaaacat?ggggcgtctt?tggtctggtc?atccagtcat?gattccttcg?420

acaccggcag?gaattatgga?aatgttccat?gaatatggga?ttgacttgga?aggtaaaaat?480

gcagtcgtca?tcggtcgatc?caatattgtc?ggaaaaccta?tggcccagct?tcttttggca?540

aagaatgcaa?cagtaacctt?gactcactca?cgtactcata?atctttccaa?ggtggctgca?600

aaagcagata?ttctggttgt?tgcaatcggt?cgtgccaagt?ttgtgactgc?tgactttgtc?660

aaaccaggtg?cggtagtcat?tgacgttggg?atgaaccgcg?atgaaaatgg?taagctctgt?720

ggggatgttg?attatgaggc?ggttgcccca?cttgctagcc?acattacgcc?agtccctgga?780

ggtgtcggtc?ctatgaccat?tactatgctg?atggagcaaa?cctatcaggc?agcacttagg?840

acattggata?gaaaataa 858

<210>240

<211>1212

<212>DNA

＜213〉streptococcus pneumoniae

<400>240

atgtctaaat?ttaatcgtat?tcatttggtg?gtactggatt?ctgtaggaat?cggtgcagca?60

ccagatgcta?ataactttgt?caatgcaggg?gttccagatg?gagcttctga?cacactggga?120

cacatttcaa?aaacagttgg?tttgaatgtc?ccaaacatgg?ctaaaatagg?tcttggaaat?180

attcctcgtg?aaactcctct?taagactgta?gcagctgaaa?gcaatccaac?tggatatgca?240

acaaaattag?aggaagtatc?tcttggtaag?gatactatga?ctggacactg?ggaaatcatg?300

ggactcaaca?ttactgagcc?tttcgatact?ttctggaacg?gattcccaga?agaaatcctg?360

acaaaaatcg?aagaattctc?aggacgcaag?gttattcgtg?aagccaacaa?accttattca?420

ggaacggctg?ttatctatga?ttttggacca?cgtcagatgg?aaactggaga?gttgattatc?480

tatacttcag?ctgaccctgt?tttgcagatt?gctgcccacg?aagacattat?tcctttggat?540

gaattgtacc?gtatctgtga?atacgctcgt?tcgattaccc?ttgagcgtcc?tgcccttctt?600

ggtcgcatca?ttgctcgccc?ttatgtaggt?gaaccaggta?acttcactcg?tacggcaaac?660

cgtcgtgact?tggctgtatc?tccatttttc?ccaactgttt?tggataaatt?gaatgaggct?720

ggtatcgata?cttatgctgt?gggtaaaatc?aacgatatct?ttaacggtgc?tggtatcaac?780

catgacatgg?gtcacaacaa?gtcaaatagt?catggaattg?atacactatt?gaagactatg?840

ggacttgctg?agtttgaaaa?aggattctca?ttcacaaacc?tagttgactt?tgatgccctt?900

tacggccatc?gtcgtaatgc?tcacggttac?cgtgattgct?tgcatgagtt?tgatgaacgc?960

ttacctgaaa?ttatcgcagc?tatgagagag?aatgaccttc?tcttgattac?tgcggaccat?1020

ggaaatgacc?caacgtatgc?aggaacggat?cacactcggg?aatatattcc?attgttggcc?1080

tatagccctg?cctttaaagg?aaatggtctc?attccagtag?gacattttgc?agatatttca?1140

gcgactgttg?ccgataactt?tggtgtggaa?actgctatga?ttggggaaag?tttcttagat?1200

aaattggtat?aa 1212

<210>241

<211>981

<212>DNA

＜213〉streptococcus pneumoniae

<400>241

atgtttattt?ccatcagtgc?tggaattgtg?acatttttac?taactttagt?agaaattccg?60

gcctttatcc?aattttatag?aaaggcgcaa?attacaggcc?agcagatgca?tgaggatgtc?120

aaacagcatc?aggcaaaagc?tgggactcct?acaatgggag?gtttggtttt?cttgattact?180

tctgttttgg?ttgctttctt?tttcgcccta?tttagtagcc?aattcagcaa?taatgtggga?240

atgattttgt?tcatcttggt?cttgtatggc?ttggtcggat?ttttagatga?ctttctcaag?300

gtctttcgta?aaatcaatga?ggggcttaat?cctaagcaaa?aattagctct?tcagcttcta?360

ggtggagtta?tcttctatct?tttctatgag?cgcggtggcg?atatcctgtc?tgtctttggt?420

tatccagttc?atttgggatt?tttctatatt?ttcttcgctc?ttttctggct?agtcggtttt?480

tcaaacgcag?taaacttgac?agacggtgtt?gacggtttag?ctagtatttc?cgttgtgatt?540

agtttgtctg?cctatggagt?tattgcctat?gtgcaaggtc?agatggatat?tcttctagtg?600

attcttgcca?tgattggtgg?tttgctcggt?ttcttcatct?ttaaccataa?gcctgccaag?660

gtctttatgg?gtgatgtggg?aagtttggcc?ctaggtggga?tgctggcagc?tatctctatg?720

gctctccacc?aagaatggac?tctcttgatt?atcggaattg?tgtatgtttt?tgaaacaact?780

tctgttatga?tgcaagtcag?ttatttcaaa?ctgacaggtg?gtaaacgtat?tttccgtatg?840

acgcctgtac?atcaccattt?tgagcttggg?ggattgtctg?gtaaaggaaa?tccttggagc?900

gagtggaagg?ttgacttctt?cttttgggga?gtgggacttc?tagcaagtct?cctgacccta?960

gcaattttat?atttgatgta?a 981

<210>242

<211>1281

<212>DNA

＜213〉streptococcus pneumoniae

<400>242

ttgtttaaga?aaaataaaga?cattcttaat?attgcattgc?cagctatggg?tgaaaacttt?60

ttgcagatgc?taatgggaat?ggtggacagt?tatttggttg?ctcatttagg?attgatagct?120

atttcagggg?tttcagtagc?tggtaatatt?atcaccattt?atcaggcgat?tttcatcgct?180

ctgggagctg?ctatttccag?tgttatttca?aaaagcatag?ggcagaaaga?ccagtcgaag?240

ttggcctatc?atgtgactga?ggcgttgaag?attaccttac?tattaagttt?ccttttagga?300

tttttgtcca?tcttcgctgg?gaaagagatg?ataggacttt?tggggacgga?gagggatgta?360

gctgagagtg?gtggactgta?tctatctttg?gtaggcggat?cgattgttct?cttaggttta?420

atgactagtc?taggagcctt?gattcgtgca?acgcataatc?cacgtctgcc?tctctatgtt?480

agttttttat?ccaatgcctt?gaatattctt?ttttcaagtc?tagctatttt?tgttctggat?540

atggggatag?ctggtgttgc?ttgggggaca?attgtgtctc?gtttggttgg?tcttgtgatt?600

ttgtggtcac?aattaaaact?gccttatggg?aagccaactt?ttggtttaga?taaggaactg?660

ttgaccttgg?ctttaccagc?agctggagag?cgacttatga?tgagggctgg?agatgtagtg?720

atcattgcct?tggtcgtttc?ttttgggacg?gaggcagttg?ctgggaatgc?aatcggagaa?780

gtcttgaccc?agtttaacta?tatgcctgcc?tttggcgtcg?ctacggcaac?ggtcatgctg?840

ttggcccgag?cagttggaga?ggatgattgg?aaaagagttg?ctagtttgag?taaacaaacc?900

ttttggcttt?ctctgttcct?catgttgccc?ctgtccttta?gtatatatgt?cttgggtgta?960

ccattaactc?atctctatac?gactgattct?ctagcggtgg?aggctagtgt?tctagtgaca?1020

ctgttttcac?tacttgggac?ccctatgacg?acaggaacag?tcatctatac?ggcagtctgg?1080

cagggattag?gaaatgcacg?cctccctttt?tatgcgacaa?gtataggaat?gtggtgtatc?1140

cgcattggga?caggatatct?gatggggatt?gtgcttggtt?ggggcttgcc?tggtatttgg?1200

gcagggtctc?tcttggataa?tggttttcgc?tggttatttc?tacgctatcg?ttaccagcgc?1260

tatatgagct?tgaaaggata?g 1281

<210>243

<211>1263

<212>DNA

＜213〉streptococcus pneumoniae

<400>243

atgcaaactc?aagaaaaaca?ctcgcaagca?gccgttcttg?gcttgcagca?cttactagcc?60

atgtactcag?gatctatcct?ggttcccatc?atgattgcga?cagcccttgg?ctattcagct?120

gagcagttga?cctacctgat?ttctacagat?atcttcatgt?gtggggtggc?aaccttcctc?180

caactccaac?tcaacaaata?ctttgggatt?ggactcccag?tcgttcttgg?agttgcattc?240

cagtcggtcg?ctcccttgat?tatgattggg?caaagccatg?gtagtggcgc?tatgtttggt?300

gcccttatcg?catctgggat?ttacgtggtt?cttgtttcag?gcatcttctc?aaaagtagcc?360

aatctcttcc?catctatcgt?aacaggatct?gttattacca?cgattggttt?aaccttgatc?420

cctgtcgcta?ttggaaatat?gggaaataac?gttccagagc?caactggtca?aagtctcttg?480

cttgcagcta?ttactgttct?gattatcctc?ttgatcaaca?tctttaccaa?aggatttatc?540

aagtctatct?ctattttgat?tggtctggtt?gttggaactg?ccattgctgc?tactatgggc?600

ttggtggact?tctctcctgt?tgcggtagct?ccacttgtcc?atgtcccaac?tccactctac?660

tttgggatgc?caacctttga?aatctcatct?attgtcatga?tgtgtatcat?cgcaacggtg?720

tctatggttg?agtcaactgg?tgtttatctg?gccttgtctg?atatcacaaa?ggatccaatc?780

gacagcacgc?gccttcgcaa?cggataccgc?gcagaaggtt?tggccgtact?tctcggagga?840

atctttaaca?ccttccctta?caccggattt?tcacaaaacg?ttggtttggt?taaattgtca?900

ggcatcaaaa?aacgcctgcc?aatctactac?gcagctggtt?tcctggttct?ccttggactg?960

cttcctaagt?ttggcgccct?tgcccaaatc?attccaagct?ccgtcctcgg?tggtgccatg?1020

ctggtaatgt?ttggttttgt?atcaattcaa?gggatgcaaa?tcctcgcccg?tgttgacttt?1080

gctaacaatg?aacacaactt?ccttatcgca?gctgtttcaa?tcgctgcagg?tgtcggtctc?1140

aacaacagta?atctctttgt?cagcatgccg?acagccttcc?aaatgttctt?ctcaaacgga?1200

atcgtcgtag?ccagcctact?cgctattgtc?ctcaatgccg?tattaaatca?taaaaagaaa?1260

taa 1263

<210>244

<211>2355

<212>DNA

＜213〉streptococcus pneumoniae

<400>244

atgaaagata?gaataaaaga?atatttacaa?gacaagggaa?aggtgactgt?taatgatttg?60

gctcaggctt?tgggaaaaga?cagttccaag?gattttcgtg?agttgattaa?aaccttgtcc?120

ttaatggaaa?gaaagcacca?aattcgtttt?gaagaagatg?gtagtctgac?attagaaatt?180

aagaaaaaac?atgagattac?cctcaagggg?atttttcatg?cccataaaaa?tggctttggc?240

tttgttagtc?tggaaggcga?ggaggacgac?ctttttgtag?ggaaaaatga?tgtcaactat?300

gctattgatg?gtgataccgt?cgaggtagtg?attaagaaag?tcgctgaccg?caataaggga?360

acagcagcag?aagccaaaat?tattgatatc?ctagaacaca?gtttgacaac?agttgtcggg?420

caaatcgttc?tggatcagga?aaaacctaag?tatgctggct?atattcgttc?aaaaaatcag?480

aaaatcagtc?aaccgattta?tgttaagaaa?ccagccctaa?aattagaagg?aacagaagtt?540

ctcaaagtct?ttatcgataa?atacccaagc?aagaaacatg?atttctttgt?cgcgagtgtt?600

ctcgatgtag?tgggacactc?aacggatgtc?ggaattgatg?ttcttgaggt?cttggaatca?660

atggacattg?tatccgagtt?tccagaagct?gttgttaagg?aagcagaaag?tgtgcctgat?720

gctccgtctc?aaaaggatat?ggaaggtcgt?ctggatctaa?gagatgaaat?tacctttacc?780

attgacggtg?cggatgccaa?ggacttggac?gatgcagtgc?atatcaaggc?tctgaaaaat?840

ggcaatctgg?agtttggggt?tcacatcgca?gatgtttctt?attatgtgac?cgaggggtct?900

gcccttgaca?aggaagccct?taaccgtgcg?acttctgttt?acgtgacaga?ccgagtggtg?960

ccaatgcttc?cagaacgact?atcaaatggc?atctgctctc?tcaatcccca?agttgaccgc?1020

ctgacccagt?ctgctattat?ggagattgat?aaacatggtc?gtgtggtcaa?ctataccatt?1080

acacaaacag?ttatcaagac?cagttttcgt?atgacctata?gcgatgtcaa?tgatatccta?1140

gctggcgatg?aagaaaagag?aaaagaatat?cataaaattg?tatcaagtat?cgaactcatg?1200

gccaagcttc?atgaaacttt?agaaaacatg?cgtgtgaaac?gtggagctct?caattttgat?1260

accaatgaag?cgaagatttt?agtggataaa?caaggtaagc?ctgttgatat?cgttcttcgg?1320

cagcgtggta?ttgccgagcg?gatgattgag?tcttttatgt?tgatggctaa?tgaaacagtt?1380

gccgaacatt?tcagcaagtt?ggatttgcct?tttatctatc?gaattcacga?ggagcctaag?1440

gctgaaaagg?ttcagaagtt?tattgattat?gcttcgagtt?ttggcttgcg?catttatgga?1500

actgccagtg?agattagtca?ggaggcactt?caagacatca?tgcgtgctgt?tgagggagaa?1560

ccttatgcag?atgtattgtc?catgatgctt?cttcgctcta?tgcagcaggc?tcgttattcg?1620

gagcacaatc?acggccacta?tggactagct?gctgactatt?atactcactt?taccagtcca?1680

attcgtcgtt?atccagacct?tcttgttcac?cgtatgattc?gggattacgg?ccgttctaag?1740

gaaatagcag?agcattttga?acaagtgatt?ccagagattg?cgacccagtc?ttccaaccgt?1800

gaacgtcgtg?ccatagaagc?tgagcgtgaa?gtcgaagcca?tgaaaaaggc?tgagtatatg?1860

gaagaatacg?tgggtgaaga?gtatgatgca?gttgtatcaa?gtattgtcaa?attcggtctc?1920

tttgtcgaat?tgccaaacac?agttgaaggc?ttgattcaca?tcactaatct?gcctgaattt?1980

tatcatttca?atgagcgtga?tttgactctt?cgtggagaaa?aatcaggtat?cactttccga?2040

gtgggtcagc?agatccgtat?ccgtgttgaa?agagcggata?aaatgactgg?agagattgat?2100

ttttcattcg?tacctagtga?gtttgatgtg?attgaaaaag?gcttgaaaca?gtctagtcgt?2160

agtggcagag?ggcgtgattc?aaatcgtcgt?tcggataaga?aggaagacaa?gagaaaatca?2220

ggacgctcaa?atgataagcg?taagcattca?caaaaagaca?agaagaaaaa?aggaaagaaa?2280

cctttttaca?aggaagtagc?taagaaagga?gccaagcatg?gcaaagggcg?agggaaaggt?2340

cgtcgcacaa?aataa 2355

<210>245

<211>1542

<212>DNA

＜213〉streptococcus pneumoniae

<400>245

atgggcacaa?caggatttac?aataattgac?ttaattatct?tgattgttta?tttacttgcg?60

gtgttggttg?caggtatcta?tttctctaaa?aaagagatga?aaggaaaaga?gttctttaaa?120

ggagatggtt?cggttccttg?gtatgttact?tcggtatcca?tttttgccac?aatgctcagt?180

ccgatttcct?tcttgggact?cgctggtagc?tcttatgcag?gtagctggat?tttatggttt?240

gctcaattag?ggatggtagt?agctattcca?ctgacaattc?gttttatctt?acctatcttt?300

gcacggatag?acatcgatac?ggcatatgat?tacttggata?aacgttttaa?ttctaaagca?360

cttcgtatta?tttcagcact?cttgtttatt?atttatcaat?tgggacgtat?gtctatcatt?420

atgtacctcc?catcagctgg?tttatcagta?ttgacaggaa?ttgacatcaa?tattttgatt?480

attttgatgg?gtgtagttgc?aattgtttat?tcttatactg?gtggtctaaa?atccgtatta?540

tggacagact?ttattcaagg?tgtgattctg?attagtggtg?tcgttttagc?tttatttgta?600

ctgattgcta?atattaaagg?tggctttggt?gcagtagcag?aaacattagc?aaacgggaaa?660

ttccttgctg?caaatgaaaa?acttttcgat?cctaacttgc?tttcaaactc?catcttttta?720

attgtgatgg?gttcaggctt?tacaatcttg?tcttcctatg?cttcatctca?agatttggtt?780

caacgtttta?ctacaacaca?aaatattaag?aaacttaata?agatgttgtt?cacaaacggt?840

gttttgtcac?ttgcaactgc?aacagtcttt?tacttgattg?gtacaggctt?gtacgtattc?900

tatcaagtac?aaaatgcaga?tagtgcagct?agcaatatcc?ctcaagacca?aatctttatg?960

tactttattg?cataccagtt?accagtaggt?atcacaggtt?tgatcttggc?agcgatttat?1020

gcagcatctc?aatcaactat?ttcaacaggt?ttgaactctg?ttgcaacttc?atggacattg?1080

gatattcaag?atgtcatttc?taaaaatatg?tcagacaatc?gtcgtacgaa?aattgcacaa?1140

ttcgtatctc?tagcagtagg?tttattctca?attggtgttt?ccattgtcat?ggctcactca?1200

gatattaaat?ctgcatacga?atggttcaat?agtttcatgg?gacttgtact?tggtctactt?1260

ggtggtgtat?ttattcttgg?atttgtttct?aaaaaagcaa?ataaacaagg?tgcttatgca?1320

gcgctgattg?tatcaaccat?cgtcatggta?tttattaaat?acttccttcc?tccaacagct?1380

gttagctact?gggcatattc?attgatttca?atctctgtat?cagtagtttc?aggttatatt?1440

gtatctgttc?ttactggaaa?taaagtatct?gcacctaaat?atacaacgat?tcatgatatt?1500

acagaaatta?aagcggattc?aagttgggaa?gttcgtcact?aa 1542

<210>246

<211>1455

<212>DNA

＜213〉streptococcus pneumoniae

<400>246

atgaaattta?gtaaaaaata?tatagcagct?ggatcagctg?ttatcgtatc?cttgagtcta?60

tgtgcctatg?cactaaacca?gcatcgttcg?caggaaaata?aggacaataa?tcgtgtctct?120

tatgtggatg?gcagccagtc?aagtcagaaa?agtgaaaact?tgacaccaga?ccaggttagc?180

cagaaagaag?gaattcaggc?tgagcaaatt?gtaatcaaaa?ttacagatca?gggctatgta?240

acgtcacacg?gtgaccacta?tcattactat?aatgggaaag?ttccttatga?tgccctcttt?300

agtgaagaac?tcttgatgaa?ggatccaaac?tatcaactta?aagacgctga?tattgtcaat?360

gaagtcaagg?gtggttatat?catcaaggtc?gatggaaaat?attatgtcta?cctgaaagat?420

gcagctcatg?ctgataatgt?tcgaactaaa?gatgaaatca?atcgtcaaaa?acaagaacat?480

gtcaaagata?atgagaaggt?taactctaat?gttgctgtag?caaggtctca?gggacgatat?540

acgacaaatg?atggttatgt?ctttaatcca?gctgatatta?tcgaagatac?gggtaatgct?600

tatatcgttc?ctcatggagg?tcactatcac?tacattccca?aaagcgattt?atctgctagt?660

gaattagcag?cagctaaagc?acatctggct?ggaaaaaata?tgcaaccgag?tcagttaagc?720

tattcttcaa?cagctagtga?caataacacg?caatctgtag?caaaaggatc?aactagcaag?780

ccagcaaata?aatctgaaaa?tctccagagt?cttttgaagg?aactctatga?ttcacctagc?840

gcccaacgtt?acagtgaatc?agatggcctg?gtctttgacc?ctgctaagat?tatcagtcgt?900

acaccaaatg?gagttgcgat?tccgcatggc?gaccattacc?actttattcc?ttacagcaag?960

ctttctgcct?tagaagaaaa?gattgccaga?atggtgccta?tcagtggaac?tggttctaca?1020

gtttctacaa?atgcaaaacc?taatgaagta?gtgtctagtc?taggcagtct?ttcaagcaat?1080

ccttcttctt?taacgacaag?taaggagctc?tcttcagcat?ctgatggtta?tatttttaat?1140

ccaaaagata?tcgttgaaga?aacggctaca?gcttatattg?taagacatgg?tgatcatttc?1200

cattacattc?caaaatcaaa?tcaaattggg?caaccgactc?ttccaaacaa?tagtctagca?1260

acaccttctc?catctcttcc?aatcaatcca?ggaacttcac?atgagaaaca?tgaagaagat?1320

ggatacggat?ttgatgctaa?tcgtattatc?gctgaagatg?aatcaggttt?tgtcatgagt?1380

cacggagacc?acaatcatta?tttcttcaag?aaggacttga?cagaagagca?aattaaggtg?1440

cgcaaaaaca?tttag 1455

<210>247

<211>462

<212>DNA

＜213〉streptococcus pneumoniae

<400>247

atgaaaaaaa?gagcaatagt?ggcagtcatt?gtactgcttt?tgattgggct?ggatcagttg?60

gtcaaatcct?atatcgtcca?gcagattcca?ctgggtgaag?tgcgctcctg?gatccccaat?120

ttcgttagct?tgacctacct?gcaaaatcga?ggtgcagcct?tttctatctt?acaagatcag?180

cagctgttat?tcgctgtcat?tactctggtt?gtcgtgatag?gtgccatttg?gtatttacat?240

aaacacatgg?aggactcatt?ctggatggtc?ttgggtttga?ctctaataat?cgcgggtggt?300

cttggaaact?ttattgacag?ggtcagtcag?ggctttgttg?tggatatgtt?ccaccttgac?360

tttatcaact?ttgcaatttt?caatgtggca?gatagctatc?tgacggttgg?agtgattatt?420

ttattgattgcaatgctaaa?agaggaaata?aatggaaatt?aa 462

<210>248

<211>855

<212>DNA

＜213〉streptococcus pneumoniae

<400>248

atgaatacaa?atcttgcaag?ttttatcgtt?ggactgatca?tcgatgaaaa?cgaccgtttt?60

tactttgtgc?aaaaggatgg?tcaaacctat?gctcttgcta?aggaagaagg?ccaacataca?120

gtaggggata?cggtcaaagg?ttttgcatac?acggatatga?agcaaaaact?ccgcctgaca?180

accttagaag?tgactgccac?tcaggaccaa?tttggttggg?gacgtgtcac?agaggttcgt?240

aaggacttgg?gtgtctttgt?ggatacaggc?cttcctgaca?aggaaatcgt?tgtgtcactc?300

gatattctcc?ctgagctcaa?ggaactctgg?cctaagaagg?gcgaccaact?ctacatccgt?360

cttgaagtgg?ataagaaaga?ccgtatctgg?ggcctcttgg?cttatcaaga?agacttccaa?420

cgtcttgctc?gtcctgccta?caacaacatg?cagaaccaaa?actggccagc?cattgtttac?480

cgtctcaagc?tgtcaggaac?ttttgtttac?ctaccagaaa?ataatatgct?tggttttatt?540

catcctagcg?agcgttacgc?agagccacgt?ttggggcaag?tattagatgc?gcgcgttatt?600

ggtttccgtg?aagtggaccg?cactctgaac?ctctccctca?aaccacgctc?ctttgaaatg?660

ttggaaaacg?atgctcagat?gattttgact?tatttggaaa?gcaatggcgg?tttcatgacc?720

ttaaatgaca?agtcatctcc?agacgacatc?aaggcaacct?ttggcatttc?taaaggtcag?780

ttcaagaaag?ctttaggtgg?tcttatgaag?gctggtaaaa?tcaagcagga?ccagtttggg?840

acagagttga?tttag 855

<210>249

<211>1185

<212>DNA

＜213〉streptococcus pneumoniae

<400>249

atgaaagatg?ttagtctatt?tttattgaaa?aaagttttca?aaagccgctt?aaactggatt?60

gtcttagctt?tatttgtatc?tgtactcggt?gttacctttt?atttaaatag?tcagactgca?120

aactcacaca?gcttggagag?caggttggaa?agtcgcattg?cagccaacga?gagggctatc?180

aatgaaaatg?aagagaaact?ctcccaaatg?tctgatacca?gctcggagga?ataccagttt?240

gctaaaaata?atttagacgt?gcaaaaaaat?cttttgacgc?gaaagacaga?aattctgact?300

ttattaaaag?aagggcgctg?gaaagaagcc?tactatttgc?agtggcaaga?tgaagagaag?360

aattatgaat?ttgtatcaaa?tgacccgact?gctagccctg?gcttaaaaat?gggggttgac?420

cgcgaacgga?agatttacca?agccctgtat?cccttgaaca?taaaagcaca?tactttggag?480

tttccgaccc?acgggattga?tcagattgtc?tggattttag?aggttatcat?cccaagtttg?540

tttgtggttg?ctattatttt?tatgctaaca?caactatttg?cagaaagata?tcaaaatcat?600

ctggacacag?ctcacttata?tcctgtttca?aaagtgacat?ttgcaatatc?ctctcttgga?660

gttggagtgg?gatatgtaac?tgtgctgttt?atcggaatct?gtggcttttc?ttttctagtg?720

ggaagtctga?taagtggttt?tggacagtta?gattatccct?acccaattta?tagcttagtg?780

aatcaagaag?taactattgg?gaaaatacaa?gatgtattat?ttcctggctt?gctcttagct?840

ttcttagcct?ttatcgtcat?tgtggaagtt?gtgtacttga?ttgcttactt?tttcaagcaa?900

aaaatgcctg?tcctctttct?ttcactcatt?gggattgttg?gcttattgtt?tggtatccaa?960

accattcagc?ctcttcaaag?gattgcacat?ctgattccct?ttacttactt?gcgttcagtg?1020

gagattttat?ctggaagatt?acctaagcag?attgataatg?tcgatctaaa?ttggagcatg?1080

ggaatggtct?tacttccttg?cctgattatc?tttttgctat?tgggaattct?atttattgaa?1140

agatggggaa?gttcacagaa?aaaagaattt?tttaatagat?tctag 1185

<210>250

<211>1347

<212>DNA

＜213〉streptococcus pneumoniae

<400>250

atgatgaagt?tcatattgga?tattgttagt?acaccagcta?ttttagtagc?tttaattgca?60

atcttaggat?tagttcttca?gaagaagaaa?ttacctgata?ttattaaagg?tggaattaag?120

acctttgttg?gtttcttagt?tgtatctggt?ggtgcaggaa?ttgtacaaaa?ttctttaaat?180

ccatttggta?ccatgtttga?gcatgctttt?catttatctg?gcgttgtgcc?gaataatgaa?240

gcaattgtag?ctgtagcttt?aacaacatat?ggctcagcta?ctgcaatgat?tatgtttgca?300

ggcatggtgt?tcaatatctt?aatcgctcgt?tttactcgat?ttaaatatat?ttttttaaca?360

gggcaccaca?ctctatatat?ggcatgtatg?attgcggtca?ttttatcagt?tgctggcttt?420

actagcttgc?ctctcatctt?actaggagga?ttagcactcg?gtattattat?gagtatttcc?480

ccagcatttg?tgcaaaaata?tatggttcaa?ttaactggaa?atgacaaggt?agctttaggt?540

catttcagtt?ctttgggata?ttggttgagt?ggttttactg?gtagccttat?cggtgacaaa?600

tcaaaatcaa?cagaggacat?taaatttcca?aagagtttag?cttttttacg?tgatagtact?660

gttagtatta?ctttatccat?ggcagttatt?tacattattg?tagctatctt?tgcagggtca?720

gaatatatag?aaaaagaaat?cagtagtggt?acaagtggtc?tagtttatgc?tttacaatta?780

gcaggtcaat?ttgcagcagg?ggtatttgtt?attttagcag?gtgttcgcct?tattttgggc?840

gaaattgttc?cagcctttaa?aggtatttca?gagcgtcttg?tacctaattc?aaaacctgct?900

ttggattgtc?cgattgttta?tacttatgca?cccaatgcag?ttctaattgg?atttatctct?960

agttttgttg?gtggtttagt?aagtatggta?attatgattg?cttcaggaac?ggttgttatc?1020

ttaccaggtg?ttgtgcctca?tttcttctgt?ggagcgactg?caggtgtcat?tgggaatgca?1080

tctggtggtg?ttcgtggagc?cactattgga?gcatttttac?aaggtatttt?aatcagtttt?1140

cttccagtct?ttttaatgcc?agttttggga?ggacttggtt?tccaaggatc?aactttctca?1200

gatgcagatt?ttggtctatc?aggaattatt?ttaggaatgt?taaatcaatt?tggctcacaa?1260

gcaggcattg?tgattggtct?tgttcttatt?ctagcagtta?tgtttggagt?atcctttatt?1320

aaaaagccat?ctgcaacgga?ggaataa 1347

<210>251

<211>1002

<212>DNA

＜213〉streptococcus pneumoniae

<400>251

atgattaaaa?catttctctc?tgccctttcg?gtcattctct?tttctatccc?tatcataact?60

tattcttttt?tcccatcttc?taatcttaac?atttggctat?ctacccaacc?tatcttggca?120

cagatttatg?ccttcccctt?agctactgca?actatggctg?ctattttaag?tttcttattt?180

tttttcctat?ctttttacaa?gaaaaataaa?caaatacggt?tttactctgg?cattttgctc?240

ttactatcgc?tcatattact?attattcgga?acagataaaa?ccctttcttc?tgcatcaaat?300

aagactaaaa?ccttaaaatt?agtaacttgg?aacgtcgcta?atcaaataga?agcacaacat?360

attgagcgaa?tttttagcca?ttttgacgcc?gatatggcta?tattccctga?actagctacc?420

aatatcagag?gtgagcaaga?aaaccagaga?atcaaactat?tgtttcatca?agttggactt?480

tctatggcca?actatgatat?tttcacttct?ccacctacca?atagtggaat?agctcctgtg?540

actgtgattg?tcaagaaaag?ttatggtttc?tatacagaag?ctaaaacttt?tcatacaaca?600

cggttcggga?caattgtatt?acattcgaga?aaacaaaata?taccagatat?cattgccttg?660

catactgcgc?ctcctctgcc?aggtttaatg?gaaatctgga?agcaagactt?aaacatcatt?720

cataatcaat?tggcttcaaa?atatccaaag?gctattattg?caggtgattt?taatgcaact?780

atgcgtcatg?gagcacttgc?aaaaataagc?tctcataggg?acgcattaaa?tgcactgcca?840

ccttttgaaa?gaggaacttg?gaatagccaa?agtccaaaac?tttttaatgc?aacaatagat?900

catattttat?tgcctaaaaa?ccactactat?gttaaagatt?tagacattgt?aagttttcaa?960

aactctgatc?atagatgtat?ttttacagaa?atcacatttt?aa 1002

<210>252

<211>1278

<212>DNA

＜213〉streptococcus pneumoniae

<400>252

atgaatccaa?tccaaagatc?ttgggcttat?gtcagcagaa?agcgactgag?aagttttatt?60

ttatttctga?ttttattggt?cttattggcc?ggaatttcag?cctgtttgac?tctgatgaag?120

tccaacaaaa?cagtagaaag?caatctttat?aaatcactca?atacatcttt?ttctattaag?180

aagatagaga?atggtcagac?attcaagttg?tcagacctag?catctgtaag?caagattaag?240

gggctggaaa?atgtctctcc?tgaacttgag?acggtcgcaa?aactaaaaga?caaggaagca?300

gtgactggcg?agcagagcgt?ggagcgtgat?gatttatcag?ctgcagacaa?taacttggtt?360

agcttaacgg?ctcttgagga?ttcatccaag?gatgtaacct?ttaccagttc?ggctttcaat?420

ctaaaagaag?ggcgacacct?tcaaaaaggg?gattccaaga?aaatccttat?ccacgaagaa?480

ttggctaaga?agaacggtct?ttcgcttcat?gacaagattg?gcttggatgc?tggtcagtct?540

gaatctggaa?aaggacaaac?agtagagttt?gagattatcg?gcatcttttc?tggtaaaaaa?600

caagagaaat?tcacaggctt?gtcttctgac?ttcagtgaaa?atcaagtctt?tacagactat?660

gaaagtagcc?aaaccctttt?gggcaatagt?gaagctcaag?tcagtgcagc?acgcttctat?720

gtagaaaatc?ctaaggaaat?ggacggactc?atgaagcagg?tagaaaactt?ggccttggaa?780

aatcaaggct?accaagtcga?aaaggaaaac?aaggcttttg?aacaaatcaa?agactcagtt?840

gcaactttcc?aaaccttcct?gaccatcttc?ctttatggga?tgttgatagc?aggagctgga?900

gccttaattc?tggttttgtc?tctctggttg?agagaacggg?tctatgaagt?ggggatttta?960

cttgcacttg?gaaaaggcaa?gagctcgatc?ttcctacaat?tctgtttaga?ggtagttttg?1020

gtatctcttg?gagctttgct?tccagcattt?gttgcaggaa?acgcaatcac?aacttaccta?1080

ctccaaactc?tactagcaag?tggagatcag?gcaagcttac?aagatacact?agccaaagca?1140

agcagtttat?caactagcat?cttatctttt?gcagaatcct?atgtttttct?agttctgctt?1200

agttgcttat?ctgtagccct?ttgtttccta?ttcttattta?gaaaatcacc?gaaagaaatt?1260

ttatcatcta?ttagttaa 1278

<210>253

<211>1380

<212>DNA

＜213〉streptococcus pneumoniae

<400>253

atgttacaca?acgcatttgc?ctatgttaca?aggaagtttt?tcaaatcgat?tgtcatcttc?60

ctgattattc?tcctcatggc?gagcttgagt?ttggtcggct?tgtcaatcaa?gggagctact?120

gccaaggctt?ctcaggagac?ctttaaaaat?atcaccaata?gcttctccat?gcaaatcaat?180

cgtcgcgtca?accaaggaac?gcctcgtggt?gctgggaata?tcaagggtga?agacatcaaa?240

aaaatcaccg?aaaacaaggc?cattgagtct?tatgtcaaac?gtatcaacgc?tatcggagat?300

ttgactggat?atgacctgat?tgaaacgcca?gaaaccaaga?agaatctcac?tgctgatcgt?360

gccaagcgtt?ttggaagtag?cttgatgatt?acaggtgtca?atgactcctc?taaagaagac?420

aagtttgtct?ctggttctta?taaactagtc?gaaggagagc?acttaaccaa?cgacgacaag?480

gataaaatcc?tcttgcacaa?ggacttggca?gccaaacacg?gctggaaagt?aggggacaag?540

gttaaactgg?actctaatat?ctacgatgca?gataatgaaa?aaggagccaa?ggaaacagtt?600

gaagtgacaa?tcaagggact?ctttgatggt?cataataagt?cagcagtaac?ctactcacaa?660

gaactttacg?aaaacacagc?tattacagac?attcacactg?ctgcaaaact?ttatggatac?720

acagaagaca?cagccattta?tggggacgca?accttctttg?taacagcaga?caagaacttg?780

gatgatgtta?tgaaagagtt?gaatggcatc?agtggtatca?actggaagag?ctacacactc?840

gtcaagagct?cctctaacta?cccagctctt?gagcaatcta?tctctggtat?gtacaagatg?900

gccaacctcc?tcttctgggg?tagcttgagc?ttctcagttc?tcctccttgc?cctcttgctc?960

agcctttgga?tcaacgcccg?tcgcaaggaa?gtgggaattc?tcctctctat?cggcctcaag?1020

caggcaagta?tcttgggtca?attcatcacc?gaatctatct?tgattgctat?ccctgctcta?1080

gtttctgctt?acttcctagc?taattacact?gcccgtgcaa?ttggaaacac?tgtccttgcc?1140

aatgtgactt?caggtgttgc?caaacaggct?agtaaggcgg?ctcaagcctc?taaccttggt?1200

ggtggtgcag?aagtagatgg?ctttagcaag?accttgtcga?gcctagacat?ttccattcag?1260

acatcagact?ttatcatcat?ttttgtcctt?gccttggttc?tagtggttct?cgttatggcg?1320

cttgcttcaa?gcaatctcct?tagaaaacaa?ccaaaagagc?tcttgctgga?tggtgaataa?1380

<210>254

<211>618

<212>DNA

＜213〉streptococcus pneumoniae

<400>254

atgtcacagg?ataaacaaat?gaaagctgtt?tctccccttc?tgcagcgagt?tatcaatatc?60

tcatcgattg?tcggtggggt?tgggagtttg?attttctgta?tttgggctta?tcaggctggg?120

attttacaat?ccaaggaaac?cctctctgcc?tttatccagc?aggcaggcat?ctggggtcca?180

cctctcttta?tctttttaca?gattttacag?actgtcgtcc?ctatcattcc?aggggccttg?240

acctcggtgg?ctggggtctt?tatctacggg?cacatcatcg?ggactatcta?caactatatc?300

ggcatcgtga?ttggctgtgc?cattatcttt?tatctagtgc?gcctatacgg?agctgccttt?360

gtccagtctg?tcgtcagcaa?gcgcacctac?gacaagtaca?tcgactggct?agataagggc?420

aatcgttttg?accgcttctt?tatttttatg?atgatttggc?ccattagccc?agctgacttt?480

ctctgtatgc?tggctgccct?gaccaagatg?agcttcaagc?gctacatgac?catcatcatt?540

ctgaccaaac?cctttaccct?cgtggtttat?acctacggtc?tgacctatat?tattgacttt?600

ttctggcaaa?tgctttga 618

<210>255

<211>1200

<212>DNA

＜213〉streptococcus pneumoniae

<400>255

atgagaaata?tgtgggttgt?aatcaaggaa?acctatcttc?gacatgtcga?gtcatggagt?60

ttcttcttta?tggtgatttc?gccgttcctc?tttttaggaa?tctctgtagg?aattgggcat?120

ctccaaggtt?cttctatggc?taaaaataat?aaagtggcag?tagtgacaac?agtgccatct?180

gtagcagaag?gactgaagaa?tgtaaatggt?gttaacttcg?actataaaga?cgaagcaagt?240

gccaaagaag?caattaaaga?agaaaaatta?aaaggttatt?tgaccattga?tcaagaagat?300

agtgttctaa?aggcagttta?tcatggcgaa?acatcgcttg?aaaatggaat?taaatttgag?360

gttacaggta?cactcaatga?actgcaaaat?cagcttaatc?gttcaactgc?ttccttgtct?420

caagagcagg?aaaaacgctt?agcgcagaca?attcaattca?cagaaaagat?tgatgaagcc?480

aaggaaaata?aaaagtttat?tcaaacaatt?gcagcaggtg?ccttaggatt?ctttctttat?540

atgattctga?ttacctatgc?gggtgtaaca?gctcaggaag?ttgccagtga?aaaaggcacc?600

aaaattatgg?aagtcgtttt?ttctagcata?agggcaagtc?actatttcta?tgcgcggatg?660

atggctctgt?ttctagtgat?tttaacgcat?attgggatct?atgttgtagg?tggtctggct?720

gccgttttgc?tctttaaaga?tttgccattc?ttggctcagt?ctggtatttt?ggatcacttg?780

ggagatgcta?tctcactgaa?taccttgctc?tttattttga?tcagtctttt?catgtacgta?840

gtcttggcag?ccttcctagg?atctatggtt?tctcgtcctg?aggactcagg?gaaagccttg?900

tcgcctttga?tgattttgat?tatgggtggt?ttttttggag?tgacagctct?aggtgcagct?960

ggtgacaatc?tcctcttgaa?gattggttct?tatattccct?ttatttcgac?cttctttatg?1020

ccgtttcgaa?cgattaatga?ctatgcgggg?ggagcagaag?catggatttc?acttgctatt?1080

acagtgattt?ttgcggtggt?agcaacagga?tttatcggac?gcatgtatgc?tagtctcgtt?1140

cttcaaacgg?atgatttagg?gatttggaaa?acctttaaac?gtgccttatc?ttataaatag?1200

<210>256

<211>714

<212>DNA

＜213〉streptococcus pneumoniae

<400>256

atgacagaaa?ccattaaatt?gatgaaggct?catacttcag?tgcgcaggtt?taaagagcaa?60

gaaattcccc?aagtagactt?aaatgagatt?ttgacagcag?cccagatggc?atcatcttgg?120

aagaatttcc?aatcctactc?tgtgattgtg?gtacgaagtc?aagagaagaa?agatgccttg?180

tatgaattgg?tacctcaaga?agccattcgc?cagtctgctg?ttttccttct?ctttgtcgga?240

gatttgaacc?gagcagaaaa?gggagcccga?cttcataccg?acaccttcca?accccaaggt?300

gtggaaggtc?tcttgattag?ttcggtcgat?gcagctcttg?ctggacaaaa?cgccttgttg?360

gcagctgaaa?gcttgggcta?tggtggtgtg?attatcggtt?tggttcgata?caagtctgaa?420

gaagtggcag?agctctttaa?cctacctgac?tacacctatt?ctgtctttgg?gatggcactg?480

ggtgtgccaa?atcaacatca?tgatatgaaa?ccgagactgc?cactagagaa?tgttgtcttt?540

gaggaagaat?accaagaaca?gtcaactgag?gcaatccaag?cttatgaccg?tgttcaggct?600

gactatgctg?gggcgcgtgc?gaccacaagc?tggagtcagc?gcctagcaga?acagtttggt?660

caagctgaac?caagctcaac?tagaaaaaat?cttgaacaga?agaaattatt?gtag 714

<210>257

<211>606

<212>DNA

＜213〉streptococcus pneumoniae

<400>257

atgttaaaac?ttattgctat?tgttggaaca?aattcaaaac?gttctacaaa?ccgtcaattg?60

cttcaataca?tgcaaaaaca?ctttactgac?aaagctgaaa?ttgaacttgt?tgaaatcaag?120

gccattcctg?tcttcaacaa?accagctgac?aagcaagtac?ctgctgaaat?attggaaatt?180

gctgctaaaa?tcgaagaggc?agatggcgtt?attatcggta?ctcctgagta?tgatcactct?240

attccagctg?ttttgatgag?cgctcttgct?tggttgtctt?atggtattta?cccacttttg?300

aacaaaccaa?tcatgattac?aggtgcttct?tacggtacgc?ttggttcatc?tcgtgcccaa?360

ttgcaacttc?gtcaaatctt?gaatgctcct?gaaatcaagg?caaatgttct?tccagatgaa?420

ttcttgctct?cacactctct?tcaagcattt?aacccaagtg?gcgacttggt?tgaccttgat?480

gttatcaaga?aattggatgc?catctttgat?gacttccgta?tctttgtaaa?aatcacagaa?540

aaattacgta?atgcacaaga?attacttcgc?aaagatgctg?aagactttga?ctgggaaaat?600

ttgtaa 606

<210>258

<211>843

<212>DNA

＜213〉streptococcus pneumoniae

<400>258

atgaatacct?atcaattaaa?taatggagta?gaaattccag?tattgggatt?tggaactttt?60

aaggctaagg?atggagaaga?agcctatcgt?gcagtgttag?aagccttgaa?ggctggttat?120

cgtcatattg?atacggcggc?gatttatcag?aatgaagaaa?gtgttggtca?agcaatcaaa?180

gatagcggag?ttccacgtga?agaaatgttc?gtaactacca?agctttggaa?tagtcagcaa?240

acctatgagc?aaactcgtca?agctttggaa?aaatctatag?aaaaactggg?cttggattat?300

ttggatttgt?atttgattca?ttggccgaac?ccaaaaccgc?tcagagaaaa?tgacgcatgg?360

aaaactcgca?atgcggaagt?ttggagagcg?atggaagacc?tctatcaaga?agggaaaatc?420

cgtgctatcg?gcgttagcaa?ttttcttccc?catcatttgg?atgccttgct?tgaaactgca?480

actatcgttc?ctgcggtcaa?tcaagttcgc?ttggcgccag?gtgtgtatca?agatcaagtc?540

gtagcttact?gtcgtgaaaa?gggaatttta?ttggaagctt?gggggccttt?tggacaagga?600

gaactgtttg?atagcaagca?agtccaagaa?atagcagcaa?atcacggaaa?atcggttgct?660

cagatagcct?tggcctggag?cttggcagaa?ggatttttac?cacttccaaa?atctgtcaca?720

acctctcgta?ttcaagctaa?tcttgattgc?tttggaattg?aactgagtca?tgaggagaga?780

gaaaccttaa?aaacgattgc?tgttcaatcg?ggtgctccac?gagttgatga?tgtggatttc?840

tag 843

<210>259

<211>801

<212>DNA

＜213〉streptococcus pneumoniae

<400>259

atgaggtgca?aaatgcttga?tccaattgct?attcaactag?gacccctagc?cattcgttgg?60

tatgccttat?gtattgtgac?aggcttgatt?cttgcggttt?atttgaccat?gaaagaagca?120

cctagaaaga?agatcatacc?agacgatatt?ttagatttta?tcttagtagc?ctttcccttg?180

gctattttag?gagctcgtct?ctactatgtt?attttccgat?ttgattacta?tagtcagaat?240

ttaggagaga?tttttgccat?ttggaatggt?ggtttggcca?tttacggtgg?tttgataact?300

ggggctcttg?tgctctatat?ctttgctgac?cgtaaactca?tcaatacttg?ggattttcta?360

gatattgcgg?cgcctagcgt?tatgattgct?caaagtttgg?ggcgttgggg?taatttcttt?420

aaccaagaag?cttatggtgc?aacagtggat?aatctggatt?atctacctgg?ctttatccgt?480

gaccagatgt?atattgaggg?gagctaccgt?caaccgactt?tcctttatga?gtctctatgg?540

aatctgcttg?gctttgcctt?gattctgatt?tttagacgga?aatggaagag?tctcagacga?600

ggtcatatca?cggcctttta?cttgatttgg?tatggtttcg?gtcgtatggt?tatcgaaggt?660

atgcgaacag?atagtctcat?gttcttcggc?tttcgagtgt?cccaatggct?gtcagttgtc?720

cttatcggtc?tcggtataat?gatcgttatt?tatcaaaatc?gaaagaaggc?cccttactat?780

attacagagg?aggaaaacta?a 801

<210>260

<211>390

<212>DNA

＜213〉streptococcus pneumoniae

<400>260

atgggtaaat?tatcctcaat?ccttttagga?accgtttcag?gtgcagctct?tgccttgttt?60

ttaacaagtg?ataagggcaa?acaagtttgc?agtcaggctc?aagattttct?agatgatttg?120

agagaagatc?cggagtatgc?caaggagcaa?gtctgtgaaa?aactgacaga?agttaaggag?180

caggctacag?attttgttct?gaaaacaaaa?gaacaggttg?agtcaggtga?aatcactgtg?240

gacagtatac?ttgctcaaac?taaatcctat?gcttttcaag?cgacagaagc?atcaaaaaat?300

caattaaata?atctcaagga?gcaatggcaa?gaaaaagccg?aagctcttga?tgactcagaa?360

gagattgtga?ttgatataac?agaagaataa 390

<210>261

<211>618

<212>DNA

＜213〉streptococcus pneumoniae

<400>261

atgaaaacta?aattgatctt?ttggggctct?atgctctttc?tcctctccct?ctccatcctt?60

ctgaccattt?atctggcttg?gattttctat?cctatggaga?ttcagtggct?aaacttaacg?120

aatcgagtct?atctaaaacc?agaaaccatt?caatacaatt?ttcatatctt?gatgaattat?180

ctgaccaatc?cttttagtca?ggtcttacag?atgcctgatt?ttcgttcgtc?agcagctggt?240

ctgcaccatt?tcgcagtggt?caagaatctc?tttcatttgg?ttcagctagt?agctctagtg?300

acactgccaa?gtttctatgt?ctttgtcaat?aggattgtga?aaaaggactt?tttgtctctt?360

tatcgaaaaa?gtctcctggc?tctagtagtc?ttacctgtga?tgattggact?tgggggagtt?420

ttgattggtt?ttgaccaatt?ctttactctt?ttccatcaaa?ttctctttgt?gggagatgat?480

acctggcttt?ttgatccagc?caaggatcct?gttattatga?ttttgccaga?gaccttcttt?540

cttcatgcct?tcctcctctt?ttttgccctc?tatgaaaact?tctttggcta?tctgtatctg?600

aaaagtcgta?ggaagtga 618

<210>262

<211>1914

<212>DNA

＜213〉streptococcus pneumoniae

<400>262

atgacttatc?attttactga?agaatacgat?attattgtaa?ttggtgcggg?acacgctggg?60

gttgaggctt?ccttggccgc?tagccgtatg?ggctgtaagg?tcctgcttgc?gaccatcaat?120

attgaaatgc?tggctttcat?gccttgtaat?ccctctatcg?gtggttctgc?caaggggatt?180

gtcgtgcgtg?aagtcgatgc?cctcggtggc?gagatggcca?aaaccattga?caagacttac?240

atccagatga?agatgctaaa?cacagggaag?gggccagctg?tccgtgccct?tcgtgcgcag?300

gctgacaagg?aactttactc?taaggagatg?cgcaagacgg?ttgaaaacca?agaaaatctg?360

acccttcgtc?aaaccatgat?tgatgagatt?ttggtggaag?atggcaaggt?tgtcggtgtg?420

cgtacagcca?cccatcaaga?atatgctgct?aaggctgtta?ttgtgacgac?agggactgct?480

ctccgtgggg?aaattatcat?cggagacctc?aagtactcat?caggtcctaa?ccacagcttg?540

gcttctatta?acctagctga?caatctcaag?gaactgggtc?tcgaaatcgg?tcgtttcaag?600

acaggaaccc?ctccacgtgt?caaggcttct?tctatcaatt?acgatgtgac?agaaattcag?660

ccaggagacg?aagtgcctaa?tcatttctca?tacacttcac?gtgatgagga?ttatgtcaag?720

gaccaagtac?catgctggtt?gacctatacc?aatggtacca?gtcatgagat?tatccaaaac?780

aacctccacc?gtgcgcctat?gtttacaggt?gtggtcaagg?gagtggggcc?tcgttactgt?840

ccgtcgattg?aagacaagat?tgtgcgcttt?gcggacaagg?aacgtcacca?actcttcctt?900

gagccagaag?ggcgcaatac?tgaggaagtc?tatgtgcaag?gactttcaac?cagtctgcct?960

gaggatgtcc?agcgtgactt?ggtgcattcc?atcaaaggtt?tggaaaatgc?agagatgatg?1020

cggacaggtt?atgctattga?gtatgatatg?gtcttgcctc?atcagttgcg?tgcgactttg?1080

gaaaccaaga?aaatctcagg?tctcttcact?gctggtcaga?caaatggaac?atcaggttac?1140

gaagaggcag?caggccaagg?gattatcgcg?ggtatcaatg?cggctctgaa?aatccaaggc?1200

aagcctgaat?tgattttgaa?gcgcagtgat?ggttatatcg?gggtgatgat?cgacgacttg?1260

gtgaccaagg?gaaccattga?accctaccgt?ctcttgacca?gtcgtgctga?ataccgtctc?1320

attcttcgtc?atgacaatgc?tgatatgcgc?ttgactgaga?tgggacgcga?gattggcctt?1380

gtggacgatg?aacgctgggc?tcgttttgaa?atcaagaaaa?atcaatttga?taatgagatg?1440

aagcgcctag?acagtatcaa?actcaagcca?gtcaaggaaa?ccaatgccaa?ggttgaggag?1500

atgggcttca?aacccttgac?cgatgcagtg?acagccaagg?aattccttcg?ccgtccagaa?1560

gtttcttacc?aagatgtggt?ggccttcatc?ggaccagctg?cagaagactt?ggatgacaag?1620

attatcgaat?tgattgaaac?agaaatcaag?tatgaaggct?atatttccaa?agccatggac?1680

caggttgcca?agatgaaacg?catggaagaa?aaacgcattc?cggccaatat?cgactgggat?1740

gacattgatt?ctatcgcaac?cgaagcccgt?cagaagttca?aactcatcaa?tccagaaacc?1800

atcggccaag?ccagccgtat?ttcgggagta?aacccagcag?atatttctat?tttgatggtg?1860

tatctggaag?gtaaaaatcg?tagtatttct?aaaactcttc?aaaaatcaaa?atga 1914

<210>263

<211>684

<212>DNA

＜213〉streptococcus pneumoniae

<400>263

atgaaagtat?tagcttttga?tacgtccagc?aaggctcttt?ctctggctat?tttagaggat?60

aagcaggttc?ttgccgagac?gacgattaat?attaagaaaa?atcacagtat?tactcttatg?120

cctgccatcg?attttttgat?ggcaagtttg?gattggacac?ccaaggattt?ggaccgaatc?180

gtggtagctg?aagggccggg?tagctataca?ggcttgcgaa?ttgcggtagc?aactgctaag?240

accttagctc?acaccctgaa?catcgagttg?gttggtatgt?cgagtctctt?ggctctggtg?300

ccccatcaac?aagaaggttt?gtttgtcccc?ttgatggatg?cgcgtcgcaa?taatgtttat?360

gcaggatttt?atgaaaatgc?caaacctgtc?atggcagaag?cgcacctatc?ttttgaagag?420

gtgctagaaa?aagtcaaggg?tactagtcag?gtaacctttg?tcggagaagt?tggccccttt?480

gttgagcaga?ttcaaaaaca?cttgccaagg?actgattaca?aagaaacatt?gcccaatgca?540

gctaatctag?ctcttttggc?ctgggacaag?gaagcagact?ccttgcatga?ttttgtgccg?600

aattacctca?aacgagtcga?ggctgaggaa?aactggctca?agaaccatac?cgagtctggc?660

gagtcttaca?ttaaacgcct?atga 684

<210>264

<211>438

<212>DNA

＜213〉streptococcus pneumoniae

<400>264

atgatagaaa?tcaagcgaat?tcaacaacag?cctgacctag?ctcaagccat?ctacgctgtt?60

atggcagctg?tttacctagt?cagtccttgg?actctggagc?aaatccaagc?agatctgtcc?120

caagaccaga?cttggtatgc?attggcttat?gatggggcag?aagtgattgg?atttctagct?180

gtgcaggaga?atctttttga?agcagaagtc?ctgcaaatcg?ctgtcaaagg?agcttatcag?240

ggtcagggga?ttgcgtcagc?cttgtttgct?caattgccga?cagacaagga?aattttcctc?300

gaagtcagac?agtcaaatca?acgagcgcaa?gcattttaca?agaaagaaaa?gatgacagtt?360

atcgctgagc?gaaaggccta?ctaccatgac?ccagtcgagg?acgccattat?catgaagaga?420

gaaatagatg?aaggatag 438

<210>265

<211>558

<212>DNA

＜213〉streptococcus pneumoniae

<400>265

atgacaaaac?aagtcttatt?agtggatgat?gaagaacaca?ttctgaaatt?gcttgactac?60

catttaagta?aggaaggctt?ttctactcaa?ttggtgacaa?atggacggaa?ggccttagct?120

ttggcagaaa?cagaaccctt?tgattttatc?ttgcttgata?tcatgttacc?acaattagat?180

ggcatggaag?tttgtaagcg?gctgagagcc?aaaggcgtca?aaactccaat?tatgatggtt?240

tctgcgaaaa?gtgatgaatt?tgataaggtt?ttggccttgg?aattaggggc?tgatgactac?300

ctgaccaagc?cttttagccc?tagagaattg?ctggcgcgtg?tcaaggctgt?cctcaggcga?360

actaaaggag?aacaagaagg?agatgattca?gataatatcg?ctgacgattc?ttggctattt?420

gggaccttga?aagtataccc?tgagcgtcat?gaagtctaca?aggcgaataa?gttactgagt?480

ttgaccccaa?aagaatttga?aagcgataaa?aatccgtttt?ttgaagtttt?caaagtttcg?540

aaagtaaccg?cccaataa 558

<210>266

<211>1437

<212>DNA

＜213〉streptococcus pneumoniae

<400>266

atgactactt?ttaaagatgg?atttttatgg?ggtggtgctg?ttgctgctca?tcaacttgaa?60

ggtggatggc?aagaaggtgg?caagggaatt?agtgttgctg?atgttatgac?tgctggtcgt?120

catggagtag?ctcgtgaaat?tactttggga?gttttagagg?gtaaatatta?tccaaatcat?180

gaggcgatag?atttttatca?ccgttataaa?gaagatatag?cactttttgc?tgaaatggga?240

ttcaagtgct?tccgtacctc?tattgcatgg?acacgtatct?ttccaaaagg?tgatgagtta?300

gagccgaatg?aagaaggatt?acagttttat?gataatcttt?ttgatgaatg?cttaaagaat?360

ggtattgaac?ctgtcatcac?tctatctcat?tttgaaatgc?cttatcactt?agtgaccgaa?420

tatggtggtt?ggaaaaatag?gaaattgatt?gatttctttg?ctcgttttgc?agaagtcgta?480

tttaaacgtt?acaaagataa?ggttaaatat?tggatgactt?tcaatgaaat?caataatcaa?540

gcgaattatc?aggaagattt?tgcaccattt?actaactcag?gtattgtata?tgaggaaggt?600

gataatagag?aagcaattat?gtatcaagca?gcacattacg?aattagttgc?ttctgcacga?660

gctgtaaaaa?ttggtcatga?gattaatcca?gattttcaaa?taggttgtat?gattgcgatg?720

tgtccaattt?atccagttac?ttgcaatcct?aaggatatct?taatggcaat?gaaagctatg?780

cagaagcgtt?attattttgc?tgatgtgcat?gttttaggta?aatatcctga?gcatattttc?840

aagtattggg?aacgaaaagg?tatttcagtt?gattttactg?cccaggataa?agaagattta?900

cttggtggga?ctgtagatta?cattggtttc?agttactata?tgtcctttgc?tatcgactct?960

catcgtgaaa?ataatcctta?ttttgattat?cttgaaacag?aagatttagt?gaaaaataat?1020

tatgttaagg?cttctgaatg?ggagtggcaa?attgatccag?aaggtttgcg?ttatgcgtta?1080

aattggttta?cagaccacta?tcacttacca?ctctttattg?ttgaaaatgg?ttttggagct?1140

atagatcaag?ttgcagcaga?tggtatggta?catgatgatt?atagaattga?atatctaggt?1200

gcccatattc?gtgaaatgaa?aaaggctgta?gttgaagatg?gtgttgattt?aatgggttat?1260

actccatggg?gatgtattga?tttggtttca?gctggtaccg?gtgaaatgcg?gaaacgttat?1320

ggctttattt?atgtagataa?agatgataat?gggaagggaa?gttataatcg?ttccccgaaa?1380

aaatcttttg?gctggtataa?ggaagttatt?tcatctaacg?gtgaatcagt?agaatag 1437

<210>267

<211>1347

<212>DNA

＜213〉streptococcus pneumoniae

<400>267

atggatcaac?aaaacgggtt?gtttggtttt?cttgaaaacc?atgttatggg?accaatgggc?60

aaacttgctc?agtttaaagt?agtacgtgct?atcacggctg?caggtatggc?tgctgtacca?120

tttactattg?taggatcaat?gtttttggta?ttcagtattt?tgccacaagc?tttctcattt?180

tggccaattg?tggcagatat?tttctctgct?tcatttgata?aattcacatc?actttacatg?240

gttgcaaact?atgcgactat?gggttctcta?tctctttatt?tcgttctatc?acttgcatat?300

gaattgacaa?aaatttatgc?agaggaagaa?gaactcaata?tgaatcctct?taatggtgcc?360

ttgcttgcct?tgatggcttt?tgtcatgaca?gtaccgcaaa?tcatttttga?tggtggaatg?420

atgaagactg?tgacaagtct?aaaagaaggt?gcagtaattg?cagatggatg?ggcaatggga?480

aatgtagtcg?cacgttttgg?gacaacaggg?atttttaccg?caatcattat?ggcaattgtg?540

actgttctta?tttatcgtat?gtgtgttaaa?cataattggg?ttattaaaat?gcctgaagct?600

gttccagaag?gagtttctcg?tggatttacc?gctttggttc?cgggatttgt?tgttgcattt?660

gttgttatct?ttatcaacgg?tcttcttgta?gcaatgggaa?cagatatttt?taaagtcatt?720

gcaattccat?ttggttttgt?atccaatctg?actaattcgt?ggattggttt?aatgattatt?780

tatctattga?ctcaactact?ttggattgta?ggtatccacg?gtgcgaacat?tgtttttgca?840

tttgttagtc?caattgctct?tgctaacatg?gctgaaaatg?ctgctggcgg?gcacttcgct?900

gttgcaggtg?aattttctaa?tatgtttgta?attgcaggtg?gttctggtgc?aactttagga?960

ctatgtttat?atattgcttt?tgcctctaaa?tctgaacagc?ttaaagcaat?aggacgagca?1020

tctgtagttc?cagccttatt?taatattaat?gaaccattaa?tttttggatt?acctattatc?1080

tataatccag?ccttggctat?accatttatt?ttagcaccaa?tggttactgc?tactatttat?1140

tacgtagcga?attctctaaa?ctttattaag?ccaattatcg?cacaggttcc?atggccaact?1200

ccagtaggga?ttggagcttt?cttagggaca?gcagatcttc?gagctgtatt?agttgctcta?1260

gtatgtgcat?ttgcagcatt?cctagtctat?cttccattca?tccgtgtata?tgatcaaaaa?1320

ttggtgaaag?aagagcaagg?tatctaa 1347

<210>268

<211>1974

<212>DNA

＜213〉streptococcus pneumoniae

<400>268

atgaaaaaat?tttatgtaag?tccaattttt?cctattctag?taggattgat?tgcgtttgga?60

gtcttatcca?ctttcattat?ttttgttaat?aataatctgt?tgacggtttt?aattttgttt?120

ctttttgtag?gaggctatgt?ttttttattt?aagaaactga?gagtgcatta?tacaaggagt?180

gatgtagaac?agatacagta?tgtaaaccac?caagcggaag?aaagtttgac?agctctattg?240

gaacagatgc?ctgtaggtgt?tatgaaattg?aatttatctt?ctggagaggt?tgagtggttt?300

aatccctatg?ctgaattgat?tttgaccaag?gaagatggtg?attttgattt?agaagctgtt?360

caaacgatta?tcaaggcttc?agtaggaaat?ccgtctactt?atgccaagct?tggtgagaag?420

cgttatgctg?ttcatatgga?tgcttcttcc?ggtgttttgt?attttgtaga?tgtatccagg?480

gaacaagcca?taacagatga?attggtaaca?agtagaccag?tgattgggat?tgtctctgtg?540

gataattatg?atgatttgga?ggatgaaact?tctgagtcag?atattagtca?aatcaatagt?600

tttgtagcta?attttatatc?agagttttca?gaaaaacaca?tgatgttttc?tcgtcgggta?660

agtatggatc?gattttatct?atttactgac?tacacggtgc?ttgagggctt?gatgaatgat?720

aaattttctg?ttattgatgc?tttcagagaa?gagtcgaaac?agagacagtt?gcccttgacc?780

ttaagtatgg?gattttctta?tggcgatgga?aatcatgatg?agatagggaa?agttgctttg?840

ctcaatttga?acttggctga?agtacgtggt?ggcgaccagg?tggttgttaa?ggaaaacgac?900

gaaacgaaaa?atccagttta?ttttggtggt?gggtctgctg?cttcaatcaa?gcgtacacgg?960

actcgtacgc?gcgctatgat?gacagctatt?tcagataaga?ttcggagtgt?agatcaggtt?1020

tttgtagtcg?gtcacaaaaa?tttagacatg?gatgctttgg?gctctgctgt?aggtatgcag?1080

ttgttcgcca?gcaatgtgat?tgaaaatagc?tatgctcttt?atgatgaaga?acaaatgtct?1140

ccagatattg?aacgagctgt?ttcattcata?gaaaaagaag?gagttacgaa?gttgttgtct?1200

gttaaggatg?caatggggat?ggtgaccaat?cgttctttgt?tgattcttgt?agaccattca?1260

aagacagcct?taacattatc?aaaagaattt?tatgatttat?ttacccaaac?cattgttatt?1320

gaccaccata?gaagggatca?ggattttcca?gataatgcgg?ttattactta?tatcgaaagt?1380

ggtgcaagta?gtgccagtga?gttggtaacg?gaattgattc?agttccagaa?ttctaagaaa?1440

aatcgtttga?gtcgtatgca?agcaagtgtc?ttgatggctg?gtatgatgtt?ggatactaaa?1500

aatttcacct?cgcgagtaac?tagtcggaca?tttgatgttg?ctagctatct?cagaacgcgc?1560

ggaagtgata?gtattgctat?ccaggaaatc?gctgcgacag?attttgaaga?atatcgtgag?1620

gtcaatgaac?ttattttaca?ggggcgtaaa?ttaggttcag?atgtactaat?agcagaggct?1680

aaggacatga?aatgctatga?tacagttgtt?attagtaagg?cagcagatgc?catgttagcc?1740

atgtcaggta?ttgaagcgag?ttttgttctt?gcgaagaata?cacaaggatt?tatctctatc?1800

tcagctcgaa?gtcgtagtaa?actgaatgta?caacggatta?tggaagagtt?aggcggtgga?1860

ggccacttta?atttggcagc?agctcaaatt?aaagatgtaa?ccttgtcaga?agcaggtgaa?1920

aaactgacag?aaattgtatt?aaatgaaatg?aaggaaaagg?agaaagaaga?atga 1974

<210>269

<211>1416

<212>DNA

＜213〉streptococcus pneumoniae

<400>269

atgaaagaga?aaaatatgtg?gaaagaattg?ttgaatcgtg?caggctggat?tttggtcttt?60

ttacttgccg?tccttttata?tcaggttccc?ctagtggtta?cctctatttt?gactttaaaa?120

gaagtagccc?tgctacagtc?agggctgata?gttgctggcc?tttcaattgt?ggttctggct?180

ctatttatta?tgggagctcg?taaaaccaag?ttagctagtt?ttaatttttc?tttttttaga?240

gctaaagatt?tggcacgttt?gggcttgagt?tatctagtta?ttgtcgggtc?aaatatactt?300

ggttccattt?tattgcaact?gtcaaatgag?acgacaacag?ctaaccagtc?tcagattaat?360

gatatggttc?aaaatagttc?gttgatttcc?agtttcttct?tgctagcctt?gcttgctccg?420

atttgtgagg?aaatcttgtg?tcgtgggatt?gttcctaaaa?agattttccg?aggcaaggag?480

aacttgggat?ttgtagtcgg?tacgattgtg?tttgctttat?tgcatcaacc?aagtaattta?540

ccttctttat?tgatttatgg?aggtatgtcg?acagttctat?cttggacagc?ctacaagacc?600

caacgtttgg?aaatgtcgat?cttgcttcac?atgattgtta?atgggattgc?tttctgtttg?660

ttggctcttg?tggtgattat?gagtcggaca?ttaggaattt?ctgtttaaat?gaaagagaaa?720

aatatgtgga?aagaattgtt?gaatcgtgca?ggctggattt?tggtcttttt?acttgccgtc?780

cttttatatc?aggttcccct?agtggttacc?tctattttga?ctttaaaaga?agtagccctg?840

ctacagtcag?ggctgatagt?tgctggcctt?tcaattgtgg?ttctggctct?atttattatg?900

ggagctcgta?aaaccaagtt?agctagtttt?aatttttctt?tttttagagc?taaagatttg?960

gcacgtttgg?gcttgagtta?tctagttatt?gtcgggtcaa?atatacttgg?ttccatttta?1020

ttgcaactgt?caaatgagac?gacaacagct?aaccagtctc?agattaatga?tatggttcaa?1080

aatagttcgt?tgatttccag?tttcttcttg?ctagccttgc?ttgctccgat?ttgtgaggaa?1140

atcttgtgtc?gtgggattgt?tcctaaaaag?attttccgag?gcaaggagaa?cttgggattt?1200

gtagtcggta?cgattgtgtt?tgctttattg?catcaaccaa?gtaatttacc?ttctttattg?1260

atttatggag?gtatgtcgac?agttctatct?tggacagcct?acaagaccca?acgtttggaa?1320

atgtcgatct?tgcttcacat?gattgttaat?gggattgctt?tctgtttgtt?ggctcttgtg?1380

gtgattatga?gtcggacatt?aggaatttct?gtttaa 1416

<210>270

<211>555

<212>DNA

＜213〉streptococcus pneumoniae

<400>270

atggatacac?aaaagattga?agcggctgta?aaaatgatta?tcgaggc?tgt?aggagaggac?60

gctaatcgcg?agggcttgca?ggaaacacct?gctcgtgtag?cccgtatgta?tcaagagatt?120

ttttcaggtc?ttggtcaaac?agcagaggaa?catttgtcaa?aatcctttga?aattattgac?180

gataatatgg?tggtagaaaa?ggatatcttt?ttccatacca?tgtgtgaaca?ccacttcttg?240

ccattttatg?gtagagcgca?cattgcctac?attccagatg?gtcgtgtggc?aggcttgtct?300

aagctagccc?gtacggttga?agtttattcg?aaaaaaccac?aaattcaaga?acgtttgaat?360

atcgaagtgg?ccgatgcctt?gatggactat?ctaggtgcta?aaggagcctt?tgttgtcatt?420

gaggcggaac?atatgtgtat?gagtatgcgt?ggtgttagaa?aaccaggcac?tgcaaccttg?480

acgacagtag?ctcgtggtct?atttgaaaca?gataaggatc?tccgtgacca?agcttatcgt?540

ttaatggggc?tataa 555

<210>271

<211>1050

<212>DNA

＜213〉streptococcus pneumoniae

<400>271

atgaaagact?tgtttttaaa?gagaaagcag?gcctttcgta?aggagtgtct?tggttatctg?60

cgctatgtgc?tcaatgacca?ctttgtcttg?ttcctgcttg?tcctgttggg?ctttctagcc?120

taccagtaca?gtcaactctt?acaacatttt?cctgaaaatc?attggcctat?ccttttgttt?180

gtaggaatta?cgtctgtttt?acttttactt?tggggaggaa?ctgccaccta?tatggaggct?240

ccagacaagc?tctttctctt?agttggagaa?gaggaaatta?agctccatct?caagcgtcaa?300

actggcattt?ccctagtctt?ttggctcttt?gtacagaccc?ttttcttgct?gttatttgcg?360

cctttatttt?tagcaatggg?ttatggcttg?ccagtttttc?tgctctatgt?gcttttattg?420

ggggtaggaa?aatatttcca?cttttgtcaa?aaggccagca?aatttttcac?tgaaactgga?480

ctggactggg?actatgttat?ttctcaagaa?agcaagcgta?agcaagtctt?gcttcgtttc?540

tttgccctct?ttacgcaggt?caagggaatt?tcaaacagcg?ttaagcgtcg?tgcctatctg?600

gactttattt?taaaggctgt?tcagaaggtg?cctgggaaga?tttggcaaaa?tctctatctg?660

cgttcttatc?tgcgaaatgg?cgacctcttt?gctctcagtc?ttcgtcttct?cttgctttcc?720

ttgctggcgc?aggtttttat?cgagcaagct?tggattgcga?cagcagtggt?agttctcttt?780

aactacctct?tgctcttcca?gttgctggcc?ctctatcatg?cctttgacta?ccagtatttg?840

acccaactct?ttccgctgga?caaggggcaa?aaggaaaaag?gcttacagga?ggtagttcga?900

ggattgacca?gttttgtttt?acttgtggaa?ttagttgttg?ggttgattac?cttccaagaa?960

aaactagccc?ttctagcctt?actaggagct?ggtttggttt?tactagtctt?gtatttgcct?1020

tatcaggtaa?aacgtcagat?gcaggactaa 1050

<210>272

<211>1197

<212>DNA

＜213〉streptococcus pneumoniae

<400>272

atgagaaaat?caatagtatt?agcggcagat?aatgcctatc?ttattccttt?agagacgact?60

ataaagtctg?tattgtatca?caatagagat?gttgattttt?atattctcaa?cagtgatata?120

gctcctgaat?ggtttaaatt?attggggaga?aaaatggaag?ttgtgaattc?tacaattcgc?180

agtgtacaca?ttgataaaga?actttttgaa?agctataaaa?caggacctca?tataaattat?240

gcttcttact?ttagattttt?tgcgacagaa?gtggttgaat?ctgatagggt?attgtatctg?300

gattccgata?tcattgtaac?tggggaacta?gctactttgt?ttgagataga?tctcaaagga?360

tattcaattg?gtgctgttga?tgatgtctat?gcctatgaag?gacgaaaatc?tggatttaat?420

actggtatgt?tactaatgga?tgttgcaaag?tggaaagaac?attctattgt?caatagttta?480

ttggaattag?cggccgagca?gaatcaagtt?gttcatcttg?gggatcagag?tattttaaat?540

atttattttg?aggataattg?gctagcctta?gataaaacat?ataattatat?ggtgggtatt?600

gatatttatc?accttgctca?agaatgtgaa?cgtctagatg?acaatccacc?tacaattgtt?660

cactatgcta?gtcatgataa?accttggaat?acatatagta?tatctagact?acgtgaatta?720

tggtgggttt?atagagattt?ggattggtca?gagattgctt?ttcaacgttc?cgatttaaat?780

tattttgaaa?gaagcaatca?gtctaaaaaa?caagtgatgc?ttgtgacatg?gagtgcagat?840

ataaaacatt?tagagtattt?agtacaacgg?ttacctgatt?ggcattttca?tttggctgca?900

ccgtgtgatt?gttctgagga?gctgacctct?ctatcacagt?atacgaatgt?aacagtatat?960

caaaatgtat?tacatagtag?aattgattgg?ctattggacg?attctatagt?ttatttagat?1020

attaatacag?gtggagaggt?ttttaatgta?gttacaaggg?cacaagaaag?tggcaagaaa?1080

atcttcgctt?ttgatatcac?acgtaaaagt?atggatgatg?gactctatga?cggtattttt?1140

tctgtggaga?gaccagatga?tttagtggat?agaatgaaga?atatagagat?agagtaa 1197

<210>273

<211>1218

<212>DNA

＜213〉streptococcus pneumoniae

<400>273

atgactaaga?tttattcgtc?aatagcagta?aaaaaaggac?tatttacctc?atttctactg?60

tttatctatg?tattgggaag?tcgtattatt?ctcccttttg?ttgacctaaa?tactaaagat?120

tttttaggag?gttcaacagc?ctatctagcc?ttctcagccg?ccctaacagg?tgggaatcta?180

agaagtttat?caattttttc?tgttggatta?tccccttgga?tgtccgccat?gattttatgg?240

cagatgtttt?ctttttctaa?acggttgggt?ttaacatcta?cgtctataga?aatacaagat?300

cgccgtaaaa?tgtacctgac?cttgctaatt?gctgtgattc?aatccttggc?agttagcttg?360

agactgccag?tacaatcctc?ctattctgca?atattggttg?ttctaatgaa?tacaatattg?420

ctgatagcag?gaacattttt?tcttgtttgg?ttgtcagatt?taaatgcgag?tatggggatt?480

ggaggttcta?ttgtaatcct?cctatccagt?atggttttaa?atattcctca?ggatgttttg?540

gaaacatttc?agacagtaca?cattccaaca?gggattattg?tgttacttgc?tttattaacc?600

cttgtctttt?cttatttact?tgcccttatg?tatcgagctc?gctatttggt?tcctgttaat?660

aaaattggct?tacacaatcg?atttaaacgc?tattcttatc?tcgaaatcat?gttgaatcct?720

gcaggtggga?tgccttatat?gtatgtgatg?agttttctta?gtgtaccagc?ttatttgttc?780

atcttgttgg?gatttatttt?ccctaatcat?tcagggttag?cggctttatc?aaaggaattt?840

atggttggaa?agcctttgtg?ggtctatgtt?tatatttcgg?tcttattttt?atttagtatc?900

atttttgctt?ttgttacgat?gaatggagaa?gagattgcag?accgtatgaa?aaaatctgga?960

gaatacattt?atggtattta?tccaggtgcg?gatactagtc?gatttattaa?tcgattggtc?1020

cttcgtttct?cagtcatagg?tggtctcttt?aatgtgatta?tggcaggtgg?tcccatgctt?1080

tttgttttgt?ttgatgaaaa?gttattacga?ttggcaatga?ttccaggctt?atttatgatg?1140

ttcgggggca?tgatttttac?gattagagac?gaggtcaagg?ctttaaggct?aaatgagacc?1200

tatagacctt?tgatttag 1218

<210>274

<211>2292

<212>DNA

＜213〉streptococcus pneumoniae

<400>274

atgtcctctc?tttcggatca?agaattagta?gctaaaacag?tagagtttcg?tcagcgtctt?60

tccgagggag?aaagtctaga?cgatattttg?gttgaagctt?ttgctgtggt?gcgtgaagca?120

gataagcgga?ttttagggat?gtttccttat?gatgttcaag?tcatgggagc?tattgtcatg?180

cactatggaa?atgttgctga?gatgaatacg?ggggaaggta?agaccttgac?agctaccatg?240

cctgtctatt?tgaacgcttt?ttcaggagaa?ggagtgatgg?ttgtgactcc?taatgagtat?300

ttatcaaagc?gtgatgccga?ggaaatgggt?caagtttatc?gttttctagg?attgaccatt?360

ggtgtaccat?ttacggaaga?tccaaagaag?gagatgaaag?ctgaagaaaa?gaagcttatc?420

tatgcttcgg?atatcatcta?cacaaccaat?agtaatttag?gttttgatta?tctaaatgat?480

aacctagcct?cgaatgaaga?aggtaagttt?ttacgaccgt?ttaactatgt?gattattgat?540

gaaattgatg?atatcttgct?tgatagtgca?caaactcctc?tgattattgc?gggttctcct?600

cgtgttcagt?ctaattacta?tgcgatcatt?gatacacttg?taacaacctt?ggtcgaagga?660

gaggattata?tctttaaaga?ggagaaagag?gaggtttggc?tcactactaa?gggggccaag?720

tctgctgaga?atttcctagg?gattgataat?ttatacaagg?aagagcatgc?gtcttttgct?780

cgtcatttgg?tttatgcgat?tcgagctcat?aagctcttta?ctaaagataa?ggactatatc?840

attcgtggaa?atgagatggt?actggttgat?aagggaacag?ggcgtctaat?ggaaatgact?900

aaacttcaag?gaggtctcca?tcaggctatt?gaagccaagg?aacatgtcaa?attatctcct?960

gagacgcggg?ctatggcctc?gatcacctat?cagagtcttt?ttaagatgtt?taataagata?1020

tctggtatga?cagggacagg?taaggtcgcg?gaaaaagagt?ttattgaaac?ttacaatatg?1080

tctgtagtac?gcattccaac?caatcgtccg?agacaacgga?ttgactatcc?agataatcta?1140

tatatcactt?tacctgaaaa?agtgtatgca?tccttggagt?acatcaagca?ataccatgct?1200

aagggaaatc?ctttactcgt?ttttgtaggc?tcagttgaaa?tgtctcaact?ctattcgtct?1260

ctcttgtttc?gtgaagggat?tgcccataat?gtcctaaatg?ctaataatgc?ggcgcgtgag?1320

gctcagatta?tctccgagtc?aggtcagatg?ggggctgtga?cagtggctac?ctctatggca?1380

ggacgtggta?cggatatcaa?gcttggtaaa?ggagtcgcag?agcttggggg?cttgattgtt?1440

attgggactg?agcggatgga?aagtcagcgg?atcgacctac?aaattcgtgg?ccgttctggt?1500

cgtcagggag?atcctggtat?gagtaaattt?tttgtatcct?tagaggatga?tgttatcaag?1560

aaatttggtc?catcttgggt?gcataaaaag?tacaaagact?atcaggttca?agatatgact?1620

caaccggaag?tattgaaagg?tcgtaaatac?cggaaactag?tcgaaaaggc?tcagcatgcc?1680

agtgatagtg?ctggacgttc?agcacgtcgt?cagactctgg?agtatgctga?aagtatgaat?1740

atacaacggg?atatagtcta?taaagagaga?aatcgtctaa?tagatggttc?tcgtgactta?1800

gaggatgttg?ttgtggatat?cattgagaga?tatacagaag?aggtagcggc?tgatcactat?1860

gctagtcgtg?aattattgtt?tcactttatt?gtgaccaata?ttagttttca?tgttaaagag?1920

gttccagatt?atatagatgt?aactgacaaa?actgcagttc?gtagctttat?gaagcaggtg?1980

attgataaag?aactttctga?aaagaaagaa?ttacttaatc?aacatgactt?atatgaacag?2040

tttttacgac?tttcactgct?taaagccatt?gatgacaact?gggtagagca?ggtagactat?2100

ctacaacagc?tatccatggc?tatcggtggt?caatctgcta?gtcagaaaaa?tccaatcgta?2160

gagtactatc?aagaagccta?cgcgggcttt?gaagctatga?aagaacagat?tcatgcggat?2220

atggtgcgta?atctcctgat?ggggctggtt?gaggtcactc?caaaaggtga?aatcgtgact?2280

cattttccat?aa 2292

<210>275

<211>960

<212>DNA

＜213〉streptococcus pneumoniae

<400>275

atgataggga?ctttcgccgc?tgctcttgta?gctgtactag?caaatttcat?cgtccctatt?60

gaaattaccc?caaatagtgc?caatactgaa?attgcaccac?cagatgggat?tgggcaggtt?120

ctcagcaacc?tcttgctcaa?actggttgac?aacccagtca?acgccctgct?tactgctaac?180

tatattagaa?tcttatcttg?ggcagtcatt?tttggaatcg?ctatgagaga?agccagtaaa?240

aatagtcaag?aattgctaaa?aactatcgct?gacgtgactt?ctaaaattgt?cgaatggatc?300

atcaatctgg?ctccatttgg?aatccttggt?cttgttttta?aaaccatttc?tgacaaggga?360

gtcggaagcc?ttgccaacta?cggtatttta?ttggttctat?tagtaacgac?tatgcttttt?420

gttgcccctg?tggtcaaccc?tttgattgcc?ttcttcttta?tgagacgcaa?tccttaccct?480

ctagtttgga?actgcctccg?tgtcagcggt?gtgacagcct?ttttcactcg?tagttctgcg?540

actaacattc?ctgtcaacat?gaaactctgc?catgaccttg?gactcaaccc?agatacctat?600

tctgtttcta?tcccactcgg?ttctactatc?aatatggctg?gagtagcgat?taccattaac?660

cttttgaccc?ttgctgcagt?taacactctt?ggaattcctg?ttgactttgc?cacagccttt?720

gtcctcagtg?tggtagcagc?tatctcatcc?tgtgatgctt?caggtattgc?cggaggttcc?780

ctccttctta?tcccagttgc?ttgtagcctt?ttcggtattt?ctaacgatat?tgccatacaa?840

attgttgggg?ttggttttgt?gattggtgtc?atccaagact?catgtgaaac?agcccttaac?900

tcttctacag?atgtcctctt?taccgccgtt?gccgaatacg?cagcaacccg?taaaaaataa?960

<210>276

<211>954

<212>DNA

＜213〉streptococcus pneumoniae

<400>276

atgtctatta?gccaacgtac?gaccaagctc?atcttagcta?cctgtcttgc?ctgcctgctt?60

gcttattttc?tcaatctttc?gtcagcagtt?tcggctggaa?ttatcgctct?cttgagccta?120

tctgatacgc?gtagaagtac?tttaaaactg?gctcgcaatc?gtcttttttc?tatgcttcta?180

gctctggcta?tcggtgttct?agcttttcac?ttgagcggat?ttcatatctg?gagtctcggc?240

ctctatctgg?ccttctacgt?tcctttagcc?tacaagatgg?gctgggaaat?tggcatcaca?300

ccaagcactg?ttttggttag?ccatctcttg?gttcaagagt?caacctctcc?agaccttcta?360

gtcaatgaat?tccttctctt?tgctattggt?acaggatttg?ccttgcttgt?taatctctat?420

atgccttcac?gagaagagga?aatccagcac?taccacacgc?tggtggaaga?aaagttaaaa?480

gatatcctcc?agcgcttcaa?atactattta?tccagaggag?acggacgcaa?ccgagcacag?540

ctggtagcag?aattagacac?gcttttgaaa?gaagccctca?gactggtcta?tttggatcac?600

tctgaccacc?tctttcacca?gacagactac?catatccact?actttgagat?gagacagcga?660

caaagtcgta?tcctgagaaa?catggcccaa?cagattaaca?cttgtcacct?tgccgccagt?720

gaaagcctga?tcttagcgca?actcttttca?aaaattgcag?gtcaactgag?ccagaccaat?780

cctgcttctg?atttgctaga?tgaaattgaa?cgttatctgg?aagtcttccg?gaaccgcagt?840

ctgcccaaga?caagagaaga?atttgaaacc?cgcgccaccc?ttcttcaact?cctacgtgaa?900

gccaaaacct?tcatccaagt?aaaagttgat?ttttaccaaa?aatatagaca?gtaa 954

<210>277

<211>1614

<212>DNA

＜213〉streptococcus pneumoniae

<400>277

atggaaatca?tgtcgcttgc?gattgctgtt?tttgccgtca?tcattggttt?agtcattgga?60

tatgtcagca?tctcagctaa?gatgaaatca?tctcaggaag?ctgcagagtt?gatgctttta?120

aatgctgaac?aagaagcaac?taatttacgt?ggacaagctg?agcgtgaagc?ggatttactt?180

gttaatgaag?ccaaacgtga?aagcaagtct?cttaaaaaag?aagcactatt?ggaggccaaa?240

gaagaagcca?gaaaataccg?tgaagaagtg?gacgctgaat?tcaaatcaga?acgtcaagaa?300

ctcaaacaaa?tcgaaagtcg?tttgacagag?agagctacta?gccttgaccg?taaggacgac?360

aatttgacga?gtaaagaaca?aacacttgaa?caaaaagaac?aaagtatttc?tgatagagcg?420

aaaaaccttg?atgcgcgtga?agagcaatta?gaggaagtcg?aaagacaaaa?agaagcagaa?480

ctagagcgta?ttggtgcgct?gtctcaggca?gaagcacgag?atattatctt?ggctcagaca?540

gaggaaaact?tgaccaggga?gattgccagt?cgcattcgcg?aagctgagca?agaggtcaag?600

gaacgttctg?acaaaatggc?caaggacatc?ttggttcaag?ctatgcaacg?tatcgctggt?660

gaatatgtag?cggagtcaac?aaactcaaca?gttcatctgc?cagacgatac?tatgaaggga?720

cgcattattg?gtcgtgaagg?tcgtaacatt?cgtacctttg?aaagtttgac?aggggtcgat?780

gtgattatcg?acgatacacc?agaagtggtg?accttgtcag?gatttgatcc?gattcgtcgt?840

gagattgccc?gtatgactat?ggaaatgttg?ctcaaagatg?gtcgtataca?tccagctcgt?900

atcgaagagt?tggttgagaa?aaaccgtcaa?gagattgaca?ataagattcg?tgaatacggt?960

gaggctgctg?cctatgaaat?tggtgcgcca?aaccttcatc?cagacttgat?gaagattatg?1020

ggacgtttgc?agttccgtac?ttcatatgga?caaaatgttt?tgcgccattc?gattgaggtt?1080

gctaagttgg?ctggtatcat?ggcgagcgaa?cttggtgaaa?atgcggctct?tgcccgtcgt?1140

gctggattcc?ttcacgatat?cgggaaagcc?attgaccatg?aggttgaagg?tagccacgtt?1200

gaaatcggta?tggaattggc?ccgtaagtac?aaggaacccc?cagttgtggt?gaatacgatt?1260

gctagtcacc?acggagatgt?tgaagctgag?agcgtgatag?cagttatcgt?cgctgcagca?1320

gatgccttga?gcgcagcccg?tccaggtgct?cgtagtgagt?ctcttgaaag?ctacatcaag?1380

cgtctccatg?atttggaaga?aattgctaac?ggctttgaag?gagtgcaaac?tagctttgcc?1440

cttcaagcag?gacgtgaaat?tcgtatcatg?gtcaatccag?gaaaaatcaa?ggacgacaaa?1500

gtcacaatct?tggctcacaa?agttcgtaag?aaaattgaaa?acaatctcga?ttatccagga?1560

aatatcaagg?taaccgtgat?tcgcgagctt?cgtgcagtag?attatgctaa?ataa 1614

<210>278

<211>315

<212>DNA

＜213〉streptococcus pneumoniae

<400>278

atgatgttaa?aaccctctat?tgataccttg?ctcgacaagg?ttccttcaaa?atattcactc?60

gtaatcttgg?aagcaaaacg?tgcccacgaa?ttggaagcag?gtgccccagc?aactcaaggt?120

ttcaagtctg?aaaaatcaac?tcttcgcgct?ttagaagaaa?tcgaatcagg?aaacgttaca?180

attcacccag?atccagaagg?aaaacgtgaa?gcagtgcgtc?gccgtatcga?agaagaaaaa?240

cgccgcaaag?aagaagaaga?aaagaaaatc?aaagagcaaa?ttgctaaaga?aaaagaagat?300

ggtgaaaaaa?tttaa 315

<210>279

<211>792

<212>DNA

＜213〉streptococcus pneumoniae

<400>279

atgtcagcat?atcaattacc?gaccgtatgg?caggatgaag?ctagtaatca?aggagctttt?60

acggggctaa?acagaccaac?agcaggtgcc?cgtttcgaac?aaaacttgcc?aaaaggagaa?120

caagcttttc?agctttattc?actgggaaca?ccaaatggtg?tgaaggttac?tatcttattg?180

gaagaattac?tagaagctgg?ttttaaggaa?gcggcttacg?acttgtataa?gattgctatc?240

atggatgggg?atcaattcgg?atcagacttt?gtgaagctca?atccaaattc?caagattcca?300

gccttattgg?accagtcagg?tactgaaaac?gtaagagtct?ttgagtctgc?tcatattctt?360

ctttaccttg?ctgagaaatt?tggagccttt?ttaccaagta?atcctgtgga?aaaggtagaa?420

gttttgaatt?ggctattctg?gcaagcaggt?gcagcacctt?ttctaggtgg?gggatttgga?480

catttcttca?attatgctcc?tgaaaaattg?gaatatccta?ttaaccgttt?tacgatggaa?540

gtgaaacgcc?agttggattt?attggataag?gaattggctc?agaaacctta?tattgcaggc?600

aatgactata?cgattgcaga?tattgctatc?tggtcttggt?atggacagtt?agttcaagga?660

aatctttacc?aaggttctgc?aaaattcttg?gatgcctcaa?gttatcaaaa?tctagtaaaa?720

tgggcagaaa?aaattgccaa?tcgtccagct?gttaagcgtg?gcttggaagt?aacttataca?780

gaaat?taaat?ag 792

<210>280

<211>939

<212>DNA

＜213〉streptococcus pneumoniae

<400>280

ttggcaagct?tgatcacttc?tatcatcatg?ttctatgtcg?gtttcgatgt?tctaagagat?60

accattcaaa?agattctcag?tcgggaagaa?acggtcattg?atcctcttgg?tgcaactcta?120

ggaatcattt?ctgcagcgat?tatgtttgtg?gtctatctct?acaatactcg?cctcagtaag?180

aaatccaact?ccaatgcgct?gaaggcagct?gctaaggaca?atctttctga?cgctgttacc?240

tcacttggaa?ccgccattgc?catcctagct?agtagtttca?attatccgat?tgtggataaa?300

ctggttgcta?tcatcatcac?tttctttatc?ttgaagactg?cctatgatat?cttcatcgag?360

tcttccttta?gtctttcaga?tggctttgac?gaccgcctgc?tcgaggacta?ccaaaaggct?420

atcatggaaa?ttcccaaaat?cagcaaggtc?aaatcgcaaa?gaggtcgcac?ctacggtagc?480

aacatctacc?tggatattac?actagagatg?aatcctgact?tgtctgtttt?tgaaagccat?540

gaaatcgcgg?atcaggtcga?gtctatgctg?gaggagcgtt?ttggcgtctt?tgataccgat?600

gtccatatcg?aaccagcacc?tatccctgag?gatgaaattt?tagacaatgt?ctataaaaaa?660

ttgcttatgc?gtgaacaatt?gattgaccaa?ggaaaccaac?tagaagaact?cttgactgat?720

gattttgtct?atattcgcca?agatggagag?cagatggata?aagaggctta?taagaccaaa?780

aaagagttaa?attctgctat?caaggacatt?caaattactt?ccatcagtca?aaaaaccaaa?840

ctcatctgct?atgagttaga?tggtatcatc?cataccagta?tctggcgtcg?ccacgaaacc?900

tggcaaaata?tctttcatca?agaaaccaaa?aaagaatag 939

<210>281

<211>795

<212>DNA

＜213〉streptococcus pneumoniae

<400>281

atgacaatta?aactagtagc?aacggatatg?gacggaacct?tcctagatgg?gaatggacgc?60

tttgatatgg?atcgtctcaa?gtctctcttg?gtttcctaca?aggaaaaagg?gatttacttt?120

gcggtagctt?cgggtcgggg?atttctgtct?ctagaaaaat?tatttgctgg?tgttcgtgat?180

gacattattt?tcatcgcgga?aaatggcagt?ttggtagagt?atcaaggtca?ggacttgtat?240

gaagcgacta?tgtctcgtga?cttttatctg?gcaacttttg?aaaagctgaa?aacttcacct?300

tatgtagata?tcaataaact?gctcttgacg?ggtaagaagg?gttcatatgt?tctagatacg?360

gttgatgaga?cctatttgaa?agtgagtcag?cactataatg?aaaatatcca?aaaagtagcg?420

agtttggaag?atatcacaga?tgacattttc?aaatttacaa?ccaacttcac?agaagaaacg?480

ctggaagatg?gggaggcttg?ggtaaacgaa?aacgttcctg?gtgttaaggc?catgacaact?540

ggctttgaat?ccattgatat?tgttctggac?tatgtcgata?agggagtggc?cattgttgaa?600

ttagttaaaa?aacttggtat?cacaatggat?caggtcatgg?cttttggaga?caatcttaat?660

gacttacata?tgatgcaggt?tgtgggacat?cctgtagctc?ctgaaaatgc?acgacctgaa?720

attttagaat?tagcaaagac?tgtgattggt?caccataagg?aacggtcggt?tatagcttat?780

atggagggct?tataa 795

<210>282

<211>819

<212>DNA

＜213〉streptococcus pneumoniae

<400>282

atggcagata?taaaattgat?tgcattggac?ttggacggga?ccttgctgac?tactgataaa?60

aggctgacgg?atcgtaccaa?ggaaaccttg?caagctgcgc?gtgatcgtgg?tatcaaggtc?120

gtattgacaa?ctggtcgtcc?cttaaaagcc?atggatttct?ttctccatga?gttagggact?180

gacggtcagg?aagatgagta?taccattact?tttaatggtg?gattagttca?gaaaaataca?240

ggagaaatcc?ttgataaaac?agtcttttca?tatgatgatg?tggcacgttt?gtatgaagaa?300

acagagaaat?tatcactgcc?tcttgatgcc?atctcagaag?gaacagttta?tcaaatccaa?360

tcggaccaag?aaagtcttta?tgccaaattc?aatccagctt?tgacctttgt?tccagtggac?420

tttgaagact?tatctagtca?aatgacctac?aacaaatgcg?tgactgcctt?tgctcaagaa?480

cccttggatg?cagccattca?gaagatttct?ccagaattgt?ttgaccaata?tgaaatcttt?540

aaatcacgtg?aaatgttgct?agaatggtca?ccaaagaatg?ttcataaagc?aacaggtttg?600

gcaaaactaa?tcagccatct?tggaatcgac?caaagtcaag?tgatggcttg?tggtgacgag?660

gccaatgacc?tctctatgat?tgaatgggca?ggtcttggtg?ttgctatgca?aaacgctgtt?720

cctgaagtaa?aggcagccgc?aaatgtagtg?acgccgatga?ccaacgatga?ggaagctgtc?780

gcctgggcta?tcgaagaata?tgtgctaaag?gagaactaa 819

<210>283

<211>1257

<212>DNA

＜213〉streptococcus pneumoniae

<400>283

atggaaagtt?tacttattct?attattaatt?gccaatctag?ctggtctctt?tctgatttgg?60

caaaggcagg?ataggcagga?gaaacactta?agtaagagct?tggaggatca?ggcagatcat?120

ttgtcagacc?agttggatta?ccgctttgac?caagccagac?aagccagcca?gttagaccaa?180

aaagatttgg?aagtggttgt?cagcgaccgt?ttgcaagaag?tgcggattga?attgcaccaa?240

ggtctgaccc?aagtccgtca?agaaatgaca?gataatctcc?tccaaactag?agacaagaca?300

gaccaacgtc?tccaagcctt?gcaggaatca?aatgagcaac?gtttggaaca?aatgcgccag?360

acggtcgagg?aaaaactaga?aaagaccttg?cagacacgct?tacaggcttc?ctttgagaca?420

gtttctaaac?aactggagtc?tgtcaatcgt?ggccttggag?aaatgcagac?agttgcccgt?480

gatgtcggag?ctcttaacaa?ggttctctct?ggaaccaaga?cgcgagggat?tctgggagaa?540

ttgcaactgg?ggcaaattat?tgaagacatc?atgacacctg?cccagtacga?acgagaatac?600

gcaacggttg?aaaactctag?tgaacgagtg?gagtatgcca?tcaagttacc?cggacaaggc?660

gaccaagaat?acgtctatct?gccaattgac?tctaagtttc?cactggcaga?ttattaccgc?720

ttggaagaag?cctatgagac?aggtgacaag?gatgagattg?aacgctgtcg?taagtcactc?780

ctagcaagcg?tcaagcgctt?tgctagggat?attaggaaca?agtacatagc?accacctcgg?840

acgaccaatt?ttggagtttt?gtttgttccg?acagaaggtc?tctactcaga?aatcgtccgc?900

aatccggtct?tctttgatga?tttgagacgg?gaagaacaga?ttattgttgc?aggaccaagt?960

accctatcag?cccttcttaa?ctccctatca?gttggtttca?agacccttaa?tatccaaaag?1020

agtgccgacc?atatcagcaa?gactcttgcc?agtgtcaaga?ccgagtttgg?caagtttggt?1080

ggtattctgg?tcaaggcaca?aaaacatctc?caacatgcct?ctggcaatat?tgatgaatta?1140

ttaaaccgtc?gtaccatagc?tatcgagcgg?acgctccgtc?acattgagtt?gtcagaaggt?1200

gagcctgcgc?ttgatctact?ccattttcaa?gaaaatgagg?aagaatatga?agattag 1257

<210>284

<211>942

<212>DNA

＜213〉streptococcus pneumoniae

<400>284

atgaagatta?gtcacatgaa?aaaagatgag?ttatttgaag?gcttttacct?aatcaaatca?60

gctgacctga?ggcaaactcg?agctgggaaa?aactacctag?cctttacctt?ccaagatgat?120

agtggcgaga?ttgatgggaa?gctctgggat?gcccaacctc?ataacattga?ggcctttacc?180

gcaggtaagg?ttgtccacat?gaaaggacgc?cgagaagttt?ataacaatac?ccctcaagtc?240

aatcaaatta?ctctccgcct?gcctcaagct?ggtgaaccca?atgacccagc?tgatttcaag?300

gtcaagtcac?cagttgatgt?caaggaaatt?cgtgactaca?tgtcgcaaat?gattttcaaa?360

attgaaaatc?ctgtctggca?acggattgtc?cgaaatctct?acaccaagta?tgataaggaa?420

ttctactcct?atccagctgc?caagaccaac?caccatgcct?ttgaaacggg?cttggcctat?480

catacggcga?ccatggtgcg?tttggcagac?gctattagcg?aagtttatcc?tcagctcaat?540

aagagcctgc?tctatgcggg?gattatgttg?catgacttag?ctaaggtcat?cgagttgacg?600

gggccagacc?agacagagta?cacagtgcga?ggtaatcttc?ttggacatat?cgctctcatt?660

gatagcgaaa?ttaccaagac?agttatggaa?ctcggcatcg?atgataccaa?ggaagaagtc?720

gttttgcttc?gtcatgtcat?cctcagtcac?cacggcttgc?ttgagtatgg?aagcccagtc?780

cgtccacgca?ttatggaagc?agagattatc?catatgattg?acaatctgga?tgcaagcatg?840

atgatgatgt?caacagctct?tgctttggtg?gataaaggag?agatgaccaa?taaaatcttc?900

gctatggata?atcgttcctt?ctataaacca?gatttagatt?aa 942

<210>285

<211>1512

<212>DNA

＜213〉streptococcus pneumoniae

<400>285

atgagtgaaa?aagctaaaaa?agggtttaag?atgccttcat?cttacaccgt?attattgata?60

atcattgcta?ttatggcagt?gctaacttgg?tttatccctg?cgggggcctt?tatagaaggt?120

atttacgaga?ctcagcctca?aaatccacaa?gggatttggg?atgtcctcat?ggcaccgatt?180

cgggctatgc?taggtactca?tccagaggaa?ggttcgctca?ttaaagaaac?gagcgcagcg?240

attgatgtag?ccttcttcat?ccttatggtt?ggtggtttcc?ttggcattgt?caacaaaact?300

ggtgctcttg?acgtagggat?tgcctctatc?gtgaagaagt?ataagggccg?cgaaaaaatg?360

ttaattttgg?tactgatgcc?tttgtttgcc?ctcggtggta?caacttatgg?tatgggtgaa?420

gaaacaatgg?ccttctatcc?actccttgtg?ccagttatga?tggccgttgg?ttttgatagc?480

ctgactggtg?ttgcaattat?tttgctcggt?tctcaaatcg?gctgtttggc?atctactctg?540

aatccatttg?cgacaggtat?tgcttcagcg?actgcgggag?ttggtacagg?ggacggtatc?600

gtacttcgtc?tgatcttctg?ggttaccttg?actgctctta?gtacttggtt?tgtttaccgt?660

tatgcggata?agattcaaaa?agatccgact?aagtcactgg?tttatagtac?tcgcaaagaa?720

gatttgaaac?actttaacgt?agaagaatct?tcatctgtag?aatctacact?tagcagcaaa?780

caaaaatcag?ttctcttctt?atttgtgttg?acattcatct?tgatggtatt?gagcttcatt?840

ccatggacag?accttggcgt?taccattttt?gatgacttta?atacttggtt?gactggtctt?900

ccagttattg?gtaatattgt?cggttcatct?acttctgcac?taggtacttg?gtacttccca?960

gaaggcgcaa?tgctctttgc?ctttatgggt?atcctgattg?gtgttattta?tggtcttaaa?1020

gaagataaga?ttatctcttc?cttcatgaat?ggtgctgctg?acttgctcag?tgttgccttg?1080

atcgtagcga?ttgctcgtgg?tattcaagtt?atcatgaacg?acggtatgat?taccgataca?1140

atcctcaact?ggggtaaaga?aggcttgagc?ggtctatctt?cacaagtctt?tatcgttgta?1200

acttatatct?tctatctacc?tatgtcattc?ttgatcccat?cttcatctgg?tcttgccagc?1260

gcaactatgg?gtatcatggc?tccacttgga?gaatttgtaa?atgtccgtcc?tagcttgatt?1320

atcactgctt?accaatctgc?ttcaggtgtc?ttgaacttga?ttgcaccaac?atctggtatt?1380

gtgatgggag?ctcttgcact?tggacgtatc?aacattggta?cttggtggaa?attcatgggc?1440

aaactcgtag?tcgctattat?tgtagtgacc?atcgcccttc?ttctccttgg?aaccttcctt?1500

ccattcctat?aa 1512

<210>286

<211>1332

<212>DNA

＜213〉streptococcus pneumoniae

<400>286

atgaaaatag?atataacaaa?tcaagttaaa?gatgaatttc?ttatatcatt?aaaaaccttg?60

atttcctatc?cttcagtact?caatgaagga?gaaaatggaa?caccttttgg?acaagcaatc?120

caagatgtcc?tagaaaaaac?tttagagatt?tgtcgagaca?taggtttcac?tacctatctt?180

gaccctaaag?gttattacgg?atatgcagaa?atcggtcagg?gagcagagct?tctggccatt?240

ctctgtcatt?tggatgttgt?tccatcaggt?gatgaagcag?attggcagac?accgccattt?300

gaagcaacta?tcaaagacgg?ctgggtattc?ggacgtggtg?tccaagatga?taaaggccct?360

tcgctcgcag?ctctctatgc?agtaaaaagc?ttgctggacc?aaggtattca?gttcaaaaag?420

cgcgtacgct?ttatctttgg?taccgatgag?gaaaccctct?ggcgctgcat?ggcacgctac?480

aataccatcg?aagaacaggc?cagtatgggc?tttgcacctg?actcatcttt?tcctctgacc?540

tatgctgaaa?aagggcttct?acaggtcaaa?cttcatggcc?ctggatcgga?tcaactagag?600

cttgaagtag?gaggcgcctt?taacgttgta?ccagacaagg?ccaactacca?aggtctcctc?660

tatgaacagg?tttgtaacgg?tctcaaagaa?gctggttatg?attaccaaac?cactgaacaa?720

accgtaacgg?ttctcggagt?gccaaagcat?gctaaggatg?ctagtcaagg?tatcaatgct?780

gtcatccgac?tagctaccat?tcttgctcct?ctccaagaac?accctgctct?cagttttctt?840

gcaacacaag?caggtcaaga?cggcacagga?agacaaatct?ttggtgatat?agcagatgaa?900

ccttctggtc?acctatcctt?taatgtcgca?ggtctcatga?tcaatcatga?acgttctgaa?960

atccgtattg?acattcggac?tcctgtctta?gctgacaagg?aagaactagt?agagttgctt?1020

acaagatgtg?cacaaaacta?ccaactccgc?tacgaagagt?ttgactatct?agcgcctcta?1080

tacgtcgcag?aagacagtaa?actcgttagc?acactgatgc?aaatctacca?agaaaagact?1140

ggcgataaca?gtcctgctat?ttcatccggt?ggtgccactt?ttgctcgcac?catgccaaat?1200

tgtgtagcct?tcggcgcctt?attcccagga?gcgaagcaga?cagaacatca?ggcaaatgaa?1260

tgtgccgttc?tagaagattt?gtaccgtgct?atggatattt?atgccgaagc?cgtctatcga?1320

cttgcaactt?aa 1332

<210>287

<211>2349

<212>DNA

＜213〉streptococcus pneumoniae

<400>287

atgtctaatt?catttgtcaa?gttgttagtc?tctcaattat?ttgcaaattt?agcagatatt?60

ttctttagag?taacaatcat?tgctaacata?tacattattt?caaaatcagt?aattgccaca?120

tcactagttc?ctatcttaat?aggaatatcc?tcttttgttg?cgagtctttt?agttccgttg?180

gttactaaaa?ggttagcgct?aaatagggtt?ttatctttat?ctcaatttgg?aaagactata?240

ttattggcga?tactggtagg?aatgtttacc?gtaatgcaat?ccgtagcgcc?tttggtgacc?300

tatctatttg?ttgttgcaat?ttccatacta?gatggttttg?cagcacccgt?ttcctatgct?360

attgtgccac?gctatgcgac?cgatttgggt?aaggctaatt?cagccttatc?aatgactggt?420

gaagctgttc?aattgatagg?ttggggatta?ggtggactct?tgtttgcaac?aattggtctg?480

ttacctacca?cgtgtatcaa?tttagtcttg?tatatcattt?ctagctttct?gatgttattt?540

cttcctaacg?ctgaagtgga?ggtgttagag?tcagaaacta?atcttgaaat?tttgctcaaa?600

ggttggaagt?tagttgctag?aaatcctaga?ttaagacttt?ttgtatcagc?aaatttattg?660

gaaatttttt?caaatacgat?ttgggtttct?tccattatac?ttgtttttgt?aacggagtta?720

ttaaataaaa?cggaaagtta?ctggggatat?tctaatacag?catactctat?tggtattata?780

attagtggct?taattgcttt?taggctatct?gaaaagttcc?ttgctgctaa?atgggaaccc?840

caattattca?ccccaaatct?aaaaaccatc?cagaatcctt?gccttagctt?agatcctgga?900

tggtttcttt?tttcacccaa?tgggtgtttt?ttactagaca?aaaaagagtt?tcccctttat?960

ggtataagtg?tagaaaaaaa?cacaaaaaga?aaggaaactc?acatgaacag?tttaccaaat?1020

catcacttcc?aaaacaagtc?tttttaccaa?ctatctttcg?atggaggtca?tttaacccag?1080

tatggtggtc?ttatcttttt?tcaggaactt?ttttcccagt?tgaaactaaa?agagcggatt?1140

tctaagtatt?tagtaacgaa?tgaccaacgc?cgctactgtc?gttattcgga?ttcagatatc?1200

cttgtccagt?tcctctttca?actgttaaca?ggttatggaa?cggactatgc?ttgtaaagaa?1260

ttgtcagctg?atgcctactt?tccaaaattg?ttggaaggag?ggcagcttgc?ttcacagcca?1320

accttatccc?gttttctttc?cagaactgac?gaggaaacag?tccatagttt?gcgatgcctc?1380

aaccttgaat?tggtcgaatt?ctttttacag?tttcaccagc?taaaccaact?cattgtagat?1440

atcgattcta?cccatttcac?aacttatggc?aagcaagaag?gtgttgctta?taacgcccac?1500

tatcgtgctc?atggctatca?tcctctttat?gctttcgagg?ggaagacagg?ttattgtttc?1560

aatgcccagc?ttcgtcctgg?taatcgttat?tgttctgaag?aggcagacag?ctttatcaca?1620

cctgttttag?aacggtttaa?tcaacttctc?tttcgaatgg?atagtggctt?tgcgacccca?1680

aaattatacg?atttaattga?aaaaacaggg?caatactacc?tcataaaact?caagaaaaat?1740

actgttctga?gccgtcttgg?agacctttcc?ctcccttgcc?cacaggatga?ggacttaacc?1800

atcttgcccc?actccgccta?ctcagaaact?ctctatcaag?caggatcttg?gtcgcacaag?1860

cgtcgtgtct?gccagttctc?tgaacgaaaa?gaaggaaact?tgttctacga?tgttatttct?1920

ctcgttacaa?atatgacgag?tggaacaagc?caagaccagt?ttcagcttta?tcgtggacgt?1980

ggtcaagccg?agaatttcat?caaggagatg?aaggagggat?tttttggcga?taaaacggat?2040

agttcaacct?taatcaaaaa?cgaagttcgt?atgatgatga?gctgtatcgc?ctacaatctc?2100

tatctttttc?tcaaacatct?agctggaggt?gacttccaaa?ctttaacaat?caaacgcttc?2160

cgccatcttt?ttcttcacgt?ggtgggaaaa?tgtgttcgaa?caggacgcaa?gcagctcctc?2220

aaattgtcta?gtctctatgc?ctattccgaa?ttgttttcag?cactttattc?taggattaga?2280

aaagtcaacc?tgaatcttcc?tgttccttat?gaaccaccta?gaagaaaagc?gtcgttaatg?2340

atgcattaa 2349

<210>288

<211>1245

<212>DNA

＜213〉streptococcus pneumoniae

<400>288

atgatggagt?tttttcaaca?gcttcctcat?ttagagccat?atggcaatcc?tcagtatttt?60

gtttatgtga?ttgctgcaac?cttgcccatc?tttataggtc?tctttttcaa?gaaacgcttt?120

gcctggtatg?aagtgttggt?aagtctcttc?tttattgtca?ccatgttggt?gggtggaaag?180

accaatcaac?tagctgcctt?gggtatttac?ctttgctggg?aaatattgct?cctgcttttc?240

tacaagcatt?atcgaaaaag?caaggatggc?aagtgggtct?tctacttagt?tagttttctg?300

tccctacttc?cgattatctt?tgtcaaggtg?caaccagcta?tcaatggaac?gcagtctttg?360

cttgggttct?tgggaatttc?ttacctgacc?tttcgttcgg?ttggaattgt?catcgagctg?420

agagatggag?tgattaagga?ttttaccctc?tgggaattcc?tccgtttcct?tctcttcatg?480

ccaactttct?cgagtggtcc?aatcgatcgc?tttaagcgat?ttaatgaaaa?ttatcaggct?540

attcctgagc?gagatgagtt?gatggatatg?ctggatgaat?ctgtccgcta?tatcatgtgg?600

ggctttttgt?ataagtttat?cctagctcat?gttttaggag?agaccttact?acctcctctg?660

aagaatttag?ccttgcagtc?aggtggcttc?tttaatctct?atgccttggc?agttatgtat?720

acttttggtc?tggaactctt?ctttgacttt?gcaggttatt?ctatgtttgc?tttggccatc?780

tcaaacttga?tgggaatccg?tagccctatc?aactttaaca?agcccttttt?atcaagggat?840

ttaaaggagt?tttggaatcg?ctggcatatg?agtctgtcct?tctggttccg?tgactttgtc?900

tttatgcgaa?tggtgatggt?gttaaccaga?aagaaagtct?ttaaaaatcg?taatgtaacc?960

tcaagcatgg?cctacattgt?aaatatgctg?attatgggat?tttggcatgg?tgtgacctgg?1020

tactatatcg?cctatggact?ctttcatgga?ctaggcttgg?tcatcaatga?tgcctgggtt?1080

cgcaagaaaa?aaacgctcaa?taaggaacgg?aaaaaagcag?ggaaggctgc?cctacctgag?1140

aatcgctgga?ttcagttgct?tggcatggtt?gtcactttcc?atgttgtcat?gttgtcattc?1200

ttaatctttt?ctggattctt?gaataatcta?tggtttaaaa?aataa 1245

<210>289

<211>1269

<212>DNA

＜213〉streptococcus pneumoniae

<400>289

atgcttaaac?gcttatggat?gatcttcgga?ccggtcttga?tcgctggttt?gttggttttt?60

ctgctcattt?tcttttatcc?tactgagatg?catcataatc?taggagctga?aaagcgttca?120

gcagtggcta?ctactatcga?tagttttaag?gagcgaagtc?aaaaagtcag?agcactatct?180

gatccaaatg?tgcgttttgt?tcccttcttt?ggctctagtg?aatggcttcg?ttttgacggt?240

gctcatcctg?cggtattagc?tgagaaatac?aatcgttcct?accgtcctta?tcttttagga?300

caggggggag?ctgcatcgct?taaccaatat?tttggaatgc?aacagatgtt?accacagctg?360

gagaataaac?aagttgtgta?tgttatctca?cctcagtggt?tcagtaaaaa?tggctatgat?420

ccagcagcct?tccagcagta?ttttaatgga?gaccagttga?ctagttttct?gaaacatcaa?480

tctggggatc?aggctagtca?atatgcagcg?actcgcttac?tgcaacagtt?cccaaacgta?540

gctatgaagg?acctggttca?gaagttggca?agtaaagaag?aattgtcgac?agcagacaat?600

gaaatgattg?aattattggc?tcgttttaat?gaacgccaag?cttccttttt?tggtcagttt?660

tcggttagag?gctatgttaa?ctacgataag?catgtagcta?agtatttaaa?aatcttgcca?720

gaccagtttt?cttatcaggc?aatagaagat?gttgtcaaag?cagatgctga?aaaaaatact?780

tccaataatg?agatgggaat?ggaaaattat?ttctataatg?agcagatcaa?gaaggatttg?840

aagaaattaa?aggattctca?gaaaagcttt?acctatctca?agtcgccaga?gtataatgac?900

ttgcagttgg?ttttaacaca?gttttctaaa?tctaaggtaa?acccgatttt?tatcattcca?960

cctgttaata?aaaaatggat?gaactatgct?ggtctacgag?aggatatgta?ccaacaaacg?1020

gtgcagaaga?ttcgctacca?gttagaaagt?caaggtttta?ccaatatagc?agatttttct?1080

aaggacggcg?gggagccttt?ctttatgaag?gacaccattc?accttggttg?gttgggttgg?1140

ttggcttttg?acaaggcagt?tgatcctttc?ctatccaatc?ccacaccagc?tccgacttac?1200

catctgaatg?agcgcttttt?cagcaaagat?tgggcgactt?atgatggaga?tgtcaaagaa?1260

tttcaatag 1269

<210>290

<211>621

<212>DNA

＜213〉streptococcus pneumoniae

<400>290

atggagaaaa?acctcaaggc?tttgaaacaa?acaacagacc?aagaaggccc?agcaattgaa?60

cctgaaaagg?cagaggatac?caagacagtc?caaaatggtt?acttcgagga?tgcagctgtc?120

aaggaccgca?ccttgagtga?ctatgcaggt?aactggcaat?cagtttatcc?tttccttgaa?180

gacggcacgt?ttgaccaagt?ctttgactac?aaggctaagt?tgactggtaa?gatgacccag?240

gctgagtaca?aggcttacta?tacaaaaggc?tatcatacag?atgtgactaa?gattaacatt?300

actgataata?ctatggaatt?tgttcaaggt?ggacaaagca?agaaatacac?ttacaagtat?360

gtcggtaaga?aaattttgac?ttacaagaaa?ggcaatcgtg?gcgtgcgttt?cctctttgaa?420

gccacagatg?ctgacgctgg?acaattcaag?tatgttcagt?ttagtgacca?caatgttgcc?480

ccagttaagg?cagaacattt?ccatatcttc?tttggaggca?caagccaaga?agccctcttt?540

gaagaaatgg?acaactggcc?aacctactac?ccagataacc?tatctggcca?agaaatcgcc?600

caagaaatgt?tggcgcattg?a 621

<210>291

<211>444

<212>DNA

＜213〉streptococcus pneumoniae

<400>291

atgaaagatg?gtcatttgct?agcccatcat?attcgtttgt?tgaatgggcg?gatttttcaa?60

aagttactga?gtcaagatcc?tgaggctctt?tataggggtg?aacagggcaa?gattttagcg?120

gttttatgga?atagtgaaac?tggctgcgca?actgcgacag?atatcgcgct?tgcgactgga?180

cttgcgaata?atacgctgac?gactatgata?aaaaagctag?aggaacaaaa?gcttgtaatt?240

gttagtccgt?gtggaaaaga?caagcgtaag?aagtatttag?ttttaacgga?gttaggcaag?300

tcccagaaag?aagtggggca?tcgtgtcagt?cagaaattgg?atactatctt?ttacaaagga?360

ttttcagagg?aagaaattca?ccaatttgaa?ggttttcaag?aaagaatttt?ggcgaatctg?420

aaagagaagg?gaaatgaggt?ttag 444

<210>292

<211>1521

<212>DNA

＜213〉streptococcus pneumoniae

<400>292

atgactaatt?taattgcaac?ttttcaggat?cgttttagtg?attggttgac?agctctatct?60

caacatttgc?agttgtcgct?tttgaccttg?ttactagcta?ttttgcttgc?gattcccttg?120

gctgtttttc?ttcgctatca?tgagaagctg?gccgactggg?tcttgcagat?tgcaggtatt?180

ttccagacca?tcccgtctct?ggccttgttg?gggctcttta?tccctttgat?gggaattggg?240

accttgccgg?ctttgacagc?tctagtgatt?tatgcgattt?tccctatttt?gcaaaatact?300

atcactgggc?tgaagggaat?tgatccgaac?ctgcaagagg?ctgggattgc?ctttgggatg?360

accagatggg?aacgtctcaa?gaaatttgaa?attccactcg?ccatgcctgt?tatcatgtct?420

gggattcgga?cggcagctgt?tttgattatc?ggtacggcaa?ccttggcggc?cttgattggt?480

gcagggggac?taggttcctt?tattcttttg?ggaattgacc?gtaataatgc?cagtttgatt?540

ttgattgggg?cactttcttc?tgcagtgcta?gccattgcct?ttaacttcct?actaaaagtg?600

atggaaaaag?caaaattacg?gacgattttc?tcaggttttg?ccttggtggc?tttattactg?660

ggtctgtctt?atagtccagc?tcttttggtt?caaaaagaga?aggaaaactt?ggttattgct?720

gggaaaatag?gtccagaacc?agaaattttg?gccaatatgt?ataagttgct?gattgaagaa?780

aataccagca?tgactgcgac?tgttaaaccg?aattttggga?agacaagctt?cctttatgaa?840

gctctgaaaa?aaggcgatat?tgacatctat?cctgaattta?ctggtacggt?gactgaaagt?900

ttgcttcaac?catcacccaa?ggtgagtcat?gaaccagaac?aggtttatca?ggtggcgcgt?960

gatggcattg?ctaagcagga?tcatctagcc?tatctcaaac?ccatgtctta?tcaaaacacc?1020

tatgctgtag?ctgttccgaa?aaagattgct?caagaatatg?gcttgaagac?catttcagac?1080

ttgaaaaaag?tggaagggca?gttgaaggca?ggttttacac?tcgagtttaa?cgaccgtgaa?1140

gatggaaata?agggcttgca?atcaatgtat?ggtctcaatc?tcaatgtagc?gaccattgag?1200

ccagcccttc?gctatcaggc?tattcagtca?ggggatattc?aaatcacgga?tgcctattcg?1260

actgatgcgg?aattggagcg?ttatgattta?caggtcttgg?aagatgacaa?gcaactcttc?1320

ccaccttatc?aaggggctcc?actcatgaaa?gaagctcttc?tcaagaaaca?cccagagttg?1380

gaaagagttc?ttaatacatt?ggctggtaag?attacagaaa?gccagatgag?ccagctcaac?1440

taccaagtcg?gtgttgaagg?caagtcagca?aagcaagtag?ccaaggagtt?tctccaagaa?1500

caaggtttgt?tgaagaaatg?a 1521

<210>293

<211>810

<212>DNA

＜213〉streptococcus pneumoniae

<400>293

atgatgcata?cttatttgca?aaagaaaatt?gaaaatatca?aaacaaccct?aggtgaaatg?60

tcaggtggtt?accgtcgtat?ggttgcggct?atggctgatt?taggattttc?aggaactatg?120

aaggctatct?gggatgacct?ctttgcccat?cgtagttttg?cccagtggat?ttatttgctg?180

gttttaggaa?gttttcctct?ctggctggag?ttggtttacg?aacatcgtat?tgttgactgg?240

attgggatga?tttgtagctt?gacagggatt?atctgtgtaa?tctttgtatc?ggaaggtcga?300

gcaagtaatt?atctttttgg?cttgattaac?tctgttattt?accttatttt?ggccctacag?360

aaaggctttt?atggtgaggt?gctgacgaca?ctttacttca?cagtcatgca?gccaattgga?420

cttctagttt?ggatttatca?ggcacagttt?aagaaggaaa?agcaggagtt?tgtcgcgcgt?480

aaactggacg?gcaagggctg?gacaaagtat?ctttccatta?gtgtgctttg?gtggttggcc?540

tttggcttca?tttatcagtc?tattggtgcc?aatcgtccct?atcgtgattc?aatcacagat?600

gcaaccaatg?gggtagggca?aatcctcatg?acagctgttt?accgtgaaca?gtggatattc?660

tgggcggcta?ccaatgtctt?ttcaatctat?ctctggtggg?gagaaagcct?gcaaattcaa?720

gggaaatatc?taatttatct?cattaacagt?ctagttggtt?ggtatcaatg?gagcaaggca?780

gctaagcaga?atactgattt?acttaactag 810

<210>294

<211>900

<212>DNA

＜213〉streptococcus pneumoniae

<400>294

atgagaaata?tgaaggcaaa?atatgctgtt?tgggtggctt?ttttcttaaa?tttgacttat?60

gccattgttg?agtttattgc?aggtggagta?tttggttcta?gcgctgttct?tgctgactct?120

gtgcatgact?tgggagatgc?gattgcaatt?ggaatatcag?cttttctaga?aacaatctcc?180

aatcgtgaag?aagacaatca?gtacaccttg?ggctataagc?ggtttagcct?gctaggagcc?240

ttggtaacag?ctgtgattct?cgtaacgggc?tctgttctag?tcattttgga?aaatgtcacg?300

aagattttgc?atccgcaacc?agtcaatgat?gaggggattc?tctggttagg?aattattgcg?360

attactatca?atctgttagc?gagtctggtg?gttggtaagg?gaaagacaaa?gaatgagtct?420

attctgagtc?tgcattttct?ggaagatacg?ctagggtggg?tagctgttat?cctgatggcg?480

attgttcttc?gatttacgga?ctggtatatc?ctagatcctc?ttttgtccct?tgtcatttct?540

ttctttattc?tttcaaaagc?ccttccacgt?ttttggtcta?cactcaagat?tttcttggat?600

gctgtgccag?aaggtcttga?tatcaagcaa?gtaaagagtg?gcctggagcg?attggacaat?660

gtggccagcc?ttaatcagct?taatctctgg?actatggatg?ctttggaaaa?aaatgccatt?720

gtccatgttt?gtctaaaaga?aatggaacat?atggaaactt?gtaaagagtc?tattcgaatt?780

ttcctaaaag?attgtggttt?tcaaaatatt?accattgaaa?ttgatgctga?cctagaaact?840

caccaaaccc?ataagcgaaa?ggtgtgtgac?ttggaacgga?gttatgagca?tcaacattag?900

<210>295

<211>729

<212>DNA

＜213〉streptococcus pneumoniae

<400>295

atgattgaat?acaaaaatgt?agcactgcgc?tacacagaaa?aggatgtctt?gagagatgtc?60

aacttacaga?ttgaggatgg?ggaatttatg?gttttagtag?ggccttctgg?gtcaggtaag?120

acgaccatgc?tcaagatgat?taaccgtctt?ttggaaccaa?ctgatggaaa?tatttatatg?180

gatgggaagc?gcatcaaaga?ctatgatgag?cgtgaacttc?gtctttctac?tggttatgtt?240

ttacaggcta?ttgctctttt?tccaaatcta?acagttgcgg?aaaatattgc?tctcattcct?300

gaaatgaagg?ggtggagcaa?ggaagaaatt?acgaagaaaa?cagaagagct?tttggctaag?360

gttggtttac?cagtagccga?gtatgggcat?cgcttaccta?gtgaattatc?tggtggagaa?420

cagcaacggg?tcggtattgt?ccgagctatg?attggtcagc?ccaagatttt?cctcatggat?480

gaaccctttt?cggccttgga?tgctatttcg?agaaaacagt?tgcaggttct?gacaaaagaa?540

ttgcataaag?agtttgggat?gacaacgatt?tttgtaaccc?atgatacgga?tgaagccttg?600

aagttggcgg?accgtattgc?tgtcttgcag?gatggagaaa?ttcgccaggt?agcgaatccc?660

gagacaattt?taaaagcgcc?tgcaacagac?tttgtagcag?acttgtttgg?aggtagtgtt?720

catgactaa 729

<210>296

<211>1083

<212>DNA

＜213〉streptococcus pneumoniae

<400>296

atgtcagcag?ttgctatttc?agctatgacc?aaggttatgc?aagaaaccca?cggaaatcct?60

tctagtattc?atggtcatgg?tcgtcaagct?ggcaaactct?tgcgagaagc?ccgtcaggaa?120

ctagcccagt?tactaaggac?aaaacctcaa?catatctttt?tcacttctgg?tgggactgaa?180

ggcaataata?ctaccatcat?tggctactgt?cttcgtcacc?aagaacaagg?aaaacatatc?240

atcacaactg?ccatcgagca?ccatgctgtc?cttgaaacaa?ttgattactt?ggttcaacac?300

tttgggtttg?aagcaaccat?tatccagcca?gaaaatcaag?aaatcacagc?ccagcaaatt?360

caaaaggctt?tacgtgacga?tacgattttg?gtttctacca?tgtttgtcaa?taatgagaca?420

ggaaacctac?tgcccatcgc?tgaaattggc?caaatactca?agcaacaccc?tgctgcctat?480

catgttgatg?cagttcaggc?tattggtaaa?atcccaattc?attcagaaga?attgggcatt?540

gattttctca?ctgcttctgc?ccacaaattc?catggtccta?agggaatcgg?ttttctctac?600

gcatctagca?tggactttga?ttcctatcta?catggcggag?accaggaaca?gaaaaaacgt?660

gcaggaactg?aaaatctgcc?tgccattgta?ggcatggttg?cagccctaaa?agaagaccta?720

gaaaaacaag?aagaacattt?tcaacatgta?caaaatctag?aaactgcctt?tctggcagag?780

ctggagggca?ttcagtatta?cctgaataga?ggaaaacatc?atctccctta?tgttctcaat?840

attggatttc?ctggtcagaa?aaatgacctc?ttactccttc?ggctagattt?agctggaatt?900

tcaatctcta?ctggctcagc?ctgtactgca?ggcgttgtcc?aatccagcca?tgttcttgaa?960

gccatgtatg?gcgcaaattc?agaacgcttg?aaggaatccc?ttcgcatcag?tttgtcgcca?1020

caaaataccg?ttgaagacct?acaaaccctc?gcaaaaacct?taaaagaaat?tatcggaggt?1080

tag 1083

<210>297

<211>1380

<212>DNA

＜213〉streptococcus pneumoniae

<400>297

atgttattca?aattatctaa?ggaaaaaata?gagctaggct?tatctcgttt?atcgccagcc?60

cgtcgtattt?ttttgagttt?tgccttggtc?attttactag?gctctcttct?tttgagcttg?120

ccctttgtcc?aagttgaaag?ctcacgagcg?acttattttg?atcatctttt?cactgctgtc?180

tctgcagtct?gtgtgacggg?tctctcaacc?cttccagtag?ctcacaccta?taatatctgg?240

ggtcaaataa?tctgtttgct?cttgattcag?atcggtggtc?tagggctcat?gacctttatt?300

ggggttttct?atatccagag?caagcaaaag?cttagtcttc?gtagccgtgc?aactattcag?360

gatagtttta?gttatggaga?aactcgatct?ttgagaaagt?ttgtctattc?tatttttctc?420

acgacctttt?tggttgagag?cttgggagct?attttgctta?gttttcgcct?tattcctcaa?480

cttggctggg?gacgtggtct?ttttagttcc?atttttctag?cgatctcagc?cttctgtaat?540

gccggttttg?ataatttagg?gagcaccagt?ttatttgctt?ttcagaccga?tttactggtc?600

aatctggtga?ttgcaggctt?gattattaca?ggcggccttg?gttttatggt?ctggtttgat?660

ttggctggtc?atgtaggaag?aaagaaaaaa?ggacgtctgc?actttcatac?gaagcttgta?720

ctattattga?ctataggttt?gttgttattt?ggaacagcaa?ctactctctt?tcttgagtgg?780

aacaatgctg?gaacgattgg?caatctccct?gttgccgata?aggttttagt?tagctttttt?840

caaacagtga?cgatgcgaac?agctggcttt?tctacgatag?attatactca?ggctcatcct?900

gtgactcttt?tgatttatat?cttacagatg?tttctaggtg?gggcacctgg?aggaacagct?960

gggggactca?agattacgac?attttttgtc?ctcttggtct?ttgcacgaag?tgagcttcta?1020

ggcttgcctc?atgccaatgt?tgcgagacga?acgatcgcgc?cgcgaacggt?tcaaaaatcc?1080

tttagtgtct?ttattatctt?tttgatgagc?ttcttgatag?gattgattct?gctagggata?1140

acagccaaag?gcaatcctcc?ctttatccac?ctcgtatttg?aaaccatttc?agctcttagt?1200

acagttggtg?taacggcaaa?tctgactcct?gaccttggga?aattggctct?cagtgttatc?1260

atgccactta?tgtttatggg?acgaattggt?cccttgacct?tgtttgttag?cttggcagat?1320

taccatccag?aaaagaaaga?tatgattcac?tatatgaaag?cagatattag?tattggttaa?1380

<210>298

<211>666

<212>DNA

＜213〉streptococcus pneumoniae

<400>298

atgtcagatc?gtacgattgg?aattttgggc?ttgggaattt?ttgggagcag?tgtcctagct?60

gccctagcca?agcaggatat?gaatattatc?gctattgatg?accacgcaga?gcgcatcaat?120

cagtttgagc?cagttttggc?gcgtggagtg?attggtgaca?tcacagatga?agaattattg?180

agatcagcag?ggattgatac?ctgcgatacc?gttgtagtcg?cgacaggtga?aaatctggag?240

tcgagtgtgc?ttgcggttat?gcactgtaag?agtttggggg?taccgactgt?tattgctaag?300

gtcaaaagtc?agaccgctaa?gaaagtgcta?gaaaagattg?gagctgactc?ggttatctcg?360

ccagagtatg?aaatggggca?gtctctagca?cagaccattc?ttttccataa?tagtgttgat?420

gtctttcagt?tggataaaaa?tgtgtctatc?gtggagatga?aaattcctca?gtcttgggca?480

ggtcaaagtc?tgagtaaatt?agacctccgt?ggcaaataca?atctgaatat?tttgggtttc?540

cgagagcagg?aaaattcccc?attggatgtt?gaatttggac?cagatgacct?cttgaaagca?600

gatacctata?ttttggcagt?catcaacaac?cagtatttgg?ataccctagt?agcattgaat?660

tcgtaa 666

<210>299

<211>540

<212>DNA

＜213〉streptococcus pneumoniae

<400>299

atgaagttat?tgtctatcgc?aatttctagc?tataatgcag?cagcctatct?tcattactgt?60

gtggagtcgc?tagtgattgg?tggtgagcaa?gttgggattt?tgattatcaa?tgacgggtct?120

caggatcaga?ctcaggaaat?cgctgagtgt?ttagctagca?agtatcctaa?tatcgttaga?180

gccatctatc?aggaaaataa?atgccatggc?ggtgcggtca?atcgtggctt?ggtagaggct?240

tctgggcgct?attttaaagt?agttgacagt?gatgactggg?tggatcctcg?tgcctacttg?300

aaaattcttg?aaaccttgca?ggaacttgag?agcaaaggtc?aagaggtgga?tgtctttgtg?360

accaattttg?tctatgaaaa?ggaagggcag?tctcgtaaga?agagtatgag?ttacgattca?420

gtcttgcctg?ttcggcagat?ttttggctgg?gaccaggtcg?gaaatttctc?caaaggccag?480

tataccatga?tgcactcgct?gatttatcgg?acagatttgt?tgcgtgctag?ccagttctaa?540

<210>300

<211>1872

<212>DNA

＜213〉streptococcus pneumoniae

<400>300

atgaaattca?atccaaatca?aagatatact?cgttggtcta?ttcgccgtct?cagtgtcggt?60

gttgcctcag?ttgttgtggc?tagtggcttc?tttgtcctag?ttggtcagcc?aagttctgta?120

cgtgccgatg?ggctcaatcc?aaccccaggt?caagtcttac?ctgaagagac?atcgggaacg?180

aaagagggtg?acttatcaga?aaaaccagga?gacaccgttc?tcactcaagc?gaaacctgag?240

ggcgttactg?gaaatacgaa?ttcacttccg?acacctacag?aaagaactga?agtgagcgag?300

gaaacaagcc?cttctagtct?ggatacactt?tttgaaaaag?atgaagaagc?tcaaaaaaat?360

ccagagctaa?cagatgtctt?aaaagaaact?gtagatacag?ctgatgtgga?tgggacacaa?420

gcaagtccag?cagaaactac?tcctgaacaa?gtaaaaggtg?gagtgaaaga?aaatacaaaa?480

gacagcatcg?atgttcctgc?tgcttatctt?gaaaaagctg?aagggaaagg?tcctttcact?540

gccggtgtaa?accaagtaat?tccttatgaa?ctattcgctg?gtgatggtat?gttaactcgt?600

ctattactaa?aagcttcgga?taatgctcct?tggtctgaca?atggtactgc?taaaaatcct?660

gctttacctc?ctcttgaagg?attaacaaaa?gggaaatact?tctatgaagt?agacttaaat?720

ggcaatactg?ttggtaaaca?aggtcaagct?ttaattgatc?aacttcgcgc?taatggtact?780

caaacttata?aagctactgt?taaagtttac?ggaaataaag?acggtaaagc?tgacttgact?840

aatctagttg?ctactaaaaa?tgtagacatc?aacatcaatg?gattagttgc?taaagaaaca?900

gttcaaaaag?ccgttgcaga?caacgttaaa?gacagtatcg?atgttccagc?agcctaccta?960

gaaaaagcca?agggtgaagg?tccattcaca?gcaggtgtca?accatgtgat?tccatacgaa?1020

ctcttcgcag?gtgatggcat?gttgactcgt?ctcttgctca?aggcatctga?caaggcacca?1080

tggtcagata?acggcgacgc?taaaaaccca?gccctatctc?cactaggcga?aaacgtgaag?1140

accaaaggtc?aatacttcta?tcaagtagcc?ttggacggaa?atgtagctgg?caaagaaaaa?1200

caagcgctca?ttgaccagtt?ccgagcaaat?ggtactcaaa?cttacagcgc?tacagtcaat?1260

gtctatggta?acaaagacgg?taaaccagac?ttggacaaca?tcgtagcaac?taaaaaagtc?1320

actattaaca?taaacggttt?aatttctaaa?gaaacagttc?aaaaagccgt?tgcagacaac?1380

gttaaagaca?gtatcgatgt?tccagcagcc?tacctagaaa?aagccaaggg?tgaaggtcca?1440

ttcacagcag?gtgtcaacca?tgtgattcca?tacgaactct?tcgcaggtga?tggtatgttg?1500

actcgtctct?tgctcaaggc?atctgacaag?gcaccatggt?cagataacgg?tgacgctaaa?1560

aacccagccc?tatctccact?aggtgaaaac?gtgaagacca?aaggtcaata?cttctatcaa?1620

ttagccttgg?acggaaatgt?agctggcaaa?gaaaaacaag?cgctcattga?ccagttccga?1680

gcaaacggta?ctcaaactta?cagcgctaca?gtcaatgtct?atggtaacaa?agacggtaaa?1740

ccagacttgg?acaacatcgt?agcaactaaa?aaagtcacta?ttaacataaa?cggtttaatt?1800

tctaaagaaa?cagttcaaaa?agccgttgca?gacaacgtta?agacagtatc?gatgttccag?1860

cagcctacct?ag 1872

<210>301

<211>1053

<212>DNA

＜213〉streptococcus pneumoniae

<400>301

atgaaactaa?aaagttatat?tttggttgga?tatattattt?caaccctctt?aaccattttg?60

gttgtttttt?gggctgttca?aaaaatgctg?attgcgaaag?gcgagattta?ctttttgctt?120

gggatgacca?tcgttgccag?ccttgtcggt?gctgggatta?gtctctttct?cctattgcca?180

gtctttacgt?cgttgggcaa?actcaaggag?catgccaagc?gggtagcggc?caaggatttt?240

ccttcaaatt?tggaggttca?aggtcctgta?gaatttcagc?aattagggca?aacttttaat?300

gagatgtccc?atgatttgca?ggtaagcttt?gattccttgg?aagaaagcga?acgagaaaag?360

ggcttgatga?ttgcccagtt?gtcgcatgat?attaagactc?ctatcacttc?gatccaagcg?420

acggtagaag?ggattttgga?tgggattatc?aaggagtcgg?agcaagctca?ttatctagca?480

accattggac?gccagacgga?gaggctcaat?aaactggttg?aggagttgaa?ttttttgacc?540

ctaaacacag?ctagaaatca?ggtggaaact?accagtaaag?acagtatttt?tctggacaag?600

ctcttaattg?agtgcatgag?tgaatttcag?tttttgattg?agcaggagag?aagagatgtc?660

cacttgcagg?taatcccaga?gtctgcccgg?attgagggag?attatgctaa?gctttctcgt?720

atcttggtga?atctggtcga?taacgctttt?aaatattctg?ctccaggaac?caagctggaa?780

gtggtggcta?agctggagaa?ggaccagctt?tcaatcagtg?tgaccgatga?agggcagggt?840

attgccccag?aggatttgga?aaatattttc?aaacgccttt?atcgtgtcga?aacttcgcgt?900

aacatgaaga?caggtggtca?tggattagga?cttgcgattg?cgcgtgaatt?ggcccatcaa?960

ttgggtgggg?aaatcacagt?cagcagccag?tacggtctag?gaagtacctt?taccctcgtt?1020

ctcaacctct?ctggtagtga?aaataaagcc?taa 1053

<210>302

<211>528

<212>DNA

＜213〉streptococcus pneumoniae

<400>302

atgtttggtc?aaacggctca?acatggtctt?acgaatagcc?tgaaagactt?ctggattttt?60

ctgctgaata?taggtccaca?attggcgttt?ttttgccaga?tgctccgctg?ttccagatcg?120

gttgagcagg?gtactggaaa?tcaccgtcgt?gagttcaata?tgattcagca?gatattctcg?180

cattttggga?tgactcactt?gggacaaatc?aagttggtct?atcaagagtc?gattgacctt?240

gagttgctgg?tcaatgcact?taatcatcac?ttgctcattg?acagactggt?cctcacgccc?300

aatcaaataa?cgatagaaat?cgacaggcag?atagtacatg?gtcttgacct?gctgaagggg?360

cgtaaagaca?aagagattat?cgacataaaa?agtatgttca?ggcagttaga?actggctagc?420

acgcaacaaa?tctgtccgat?aaatcagcga?gtgcatcatg?gtatactggc?ctttggagaa?480

atttccgacc?tggtcccagc?caaaaatctg?ccgaacaggc?aagactga 528

<210>303

<211>477

<212>DNA

＜213〉streptococcus pneumoniae

<400>303

atggaacatt?tagcaactta?tttttcaacc?tatggaggag?ctttcttcgc?tgcattggga?60

attgtattgg?cggttggatt?aagcggtatg?gggtctgctt?atggagttgg?taaggctggg?120

caatctgccg?cagctttact?gaaagaacag?cctgaaaagt?ttgcctcagc?tttgatattg?180

caattattgc?ccggaacaca?aggattatat?ggttttgtta?ttggaatttt?aatttggttg?240

caattaactc?cagaacttcc?tttagaaaaa?ggcgttgctt?atttctttgt?agctcttcca?300

attgctattg?taggatactt?ttcagctaag?catcaaggaa?atgtagcagt?agcgggaatg?360

caaatcttgg?ctaaaagacc?aaaagaattc?atgaagggag?caattttagc?tgccatggta?420

gaaacctatg?caattcttgc?ttttgtcgta?tcattcattt?tgacccttcg?tgtataa 477

<210>304

<211>498

<212>DNA

＜213〉streptococcus pneumoniae

<400>304

atgttaaaat?cagaaaaaca?atcacgttat?caaatgttaa?atgaagaatt?gtccttccta?60

ttggaaggcg?aaaccaatgt?tttggctaat?ctttccaacg?ccagtgctct?cataaaatca?120

cgttttccta?ataccgtatt?tgcaggcttt?tatttgttcg?atggaaagga?attggtttta?180

ggccccttcc?aaggaggtgt?ttcctgcatc?cgtattgcac?taggcaaggg?tgtttgtggt?240

gaggcagctc?actttcagga?aactgttatt?gttggagatg?tgacgaccta?tctcaactat?300

atttcttgtg?atagtctagc?taaaagtgaa?attgtggtgc?cgatgatgaa?gaatggtcag?360

ttacttggag?ttctggatct?ggattcttca?gagattgagg?attacgatgc?tatggatcga?420

gattatttgg?aacaatttgt?cgctattttg?cttgaaaaga?cagcatggga?ctttacgatg?480

tttgaggaaa?aatcttaa 498

<210>305

<211>771

<212>DNA

＜213〉streptococcus pneumoniae

<400>305

atgtcagtat?tagagatcaa?agatcttcac?gttgagattg?aaggaaaaga?aattttaaaa?60

ggggttaacc?tgaccctgaa?aacaggagaa?attgccgcta?tcatgggacc?aaatggtaca?120

ggtaaatcga?ctctttctgc?cgctatcatg?ggaaatccaa?actatgaagt?aactaaaggt?180

gaagttttgt?ttgatggcgt?aaacatcctt?gagttggaag?tggatgagcg?tgcgcgtatg?240

ggacttttcc?ttgctatgca?atacccatca?gaaatccctg?gaattaccaa?tgctgagttt?300

cttcgtgccg?ctatgaatgc?gggtaaagaa?gatgatgaga?agatttcagt?tcgtgagttt?360

attactaagc?tagatgaaaa?aatggaattg?ctcaacatga?aagaagaaat?ggcagagcgt?420

tacctcaacg?aaggcttctc?tggtggtgag?aaaaaacgca?atgaaattct?tcaacttttg?480

atgttggagc?caacatttgc?tcttttggac?gagattgact?caggtcttga?tattgacgct?540

cttaaagttg?tgtctaaagg?tgtcaatgcc?atgcgtggtg?aaggttttgg?tgctatgatc?600

atcactcact?accaacgtct?tttgaactat?atcacacctg?atgtggtaca?cgtgatgatg?660

gaaggtcgtg?ttgtcctttc?tggtggtcca?gaattggctg?cgcgtttgga?acgtgaagga?720

tacgcaaaat?tagctgaaga?acttggctac?gactacaagg?aagaattgta?a 771

<210>306

<211>471

<212>DNA

＜213〉streptococcus pneumoniae

<400>306

atgccctaca?aaagacaaag?gagtttttca?atggcacttt?ctaaactaga?tagcctttat?60

atggcagtgg?tagcagacca?ttcgaaaaat?ccacatcacc?aagggaagtt?agaagatgct?120

gagcaaatca?gtctcaacaa?tccgacttgt?ggggatgtca?tcaacctctc?tgtcaagttt?180

gatgcagagg?accgtttgga?agatattgct?tttctaaatt?caggatgcac?gatttcaact?240

gcttctgcta?gtatgatgac?agatgccgtt?ttaggaaaaa?ccaaacaaga?aattttagaa?300

ctggcgacta?ttttttctga?aatggttcaa?gggcaaaaag?atgagcgtca?agaccaactt?360

ggagacgcgg?cattcttgtc?aggtgttgcc?aaattccctc?aaagaatcaa?gtgtgcaacc?420

ctagcttgga?atgcccttaa?gaaaacaatt?gaaaatcaag?aaaaacagta?a 471

<210>307

<211>1953

<212>DNA

＜213〉streptococcus pneumoniae

<400>307

atgaaaattc?aagacctatt?gagaaaagat?gtcatgttgc?tagatttgca?ggcaactgaa?60

aaaacagctg?tcatcgacga?gatgattaaa?aatttgacag?accacggtta?tgtaacagat?120

tttgaaacat?ttaaagaagg?aattttggcg?cgtgaagctt?tgacttctac?tggtttgggt?180

gatggaatcg?caatgcctca?cagcaaaaac?gctgctgtca?aagaagcgac?agttctattt?240

gctaagtcaa?ataagggtgt?tgactacgag?agcttggatg?gacaagcaac?tgacctcttc?300

ttcatgattg?cagctccaga?aggtgccaat?gatactcact?tggcagcctt?ggcagaattg?360

tctcaatact?tgatgaaaga?cggttttgca?gacaaacttc?gtcaagcaac?atctgcagac?420

caagttatcg?aactttttga?ccaagcttca?gaaaaaactg?aggaacttgt?tcaagcacct?480

gctaatgact?ctggtgactt?tatcgtagct?gttacagctt?gtacaacagg?tattgcccac?540

acttacatgg?cccaagaagc?ccttcaaaaa?gtagctgctg?aaatgggggt?tggtatcaag?600

gtcgaaacca?acggtgctag?cggtgttgga?aatcaactaa?ctgcagaaga?tatccgtaag?660

gctaaagcta?ttatcattgc?agcagacaag?gccgttgaaa?tggatcgatt?tgatggaaaa?720

ccattgatca?atcgtccagt?tgctgacggt?atccgtaaga?cagaagagct?aattaacttg?780

gctctttcag?gagatactga?agtctaccgt?gccgctaatg?gtgccaaagc?tgcaacagcc?840

tctaacgaaa?aacaaagcct?tggtggtgcc?ttgtacaaac?acttgatgag?tggtgtatct?900

caaatgttac?cattcgttat?cggtggtggt?atcatgattg?cccttgcctt?cttgattgac?960

ggtgctttgg?gtgttccaaa?tgaaaacctt?ggcaatcttg?gttcttacca?tgagttagct?1020

tctatgttca?tgaaaattgg?tggagctgcc?tttggtttga?tgcttccagt?ctttgcgggt?1080

tatgttgcct?actctattgc?tgaaaaaccg?ggtttggtag?caggtttcgt?ggctggtgct?1140

attgccaaag?aaggttttgc?ctttggtaaa?attccttatg?ccgcaggtgg?tgaagcaact?1200

tcaactcttg?caggtgtctc?atctggtttc?ctaggtgccc?ttgttggtgg?atttatcgca?1260

ggtgccttgg?ttcttgccat?caagaaatac?gttaaagttc?ctcgttcact?cgaaggtgct?1320

aaatcaatcc?ttctattgcc?acttcttgga?acaatcttga?caggatttgt?tatgctagct?1380

gtgaatatcc?caatggctgc?aatcaacact?gctatgaatg?acttcctagg?cggtcttgga?1440

ggaggttcag?ctgtccttct?tggtatcgtc?cttggtggaa?tgatggctgt?tgacatgggt?1500

ggaccagtta?ataaagcagc?ttatgtcttt?ggtacaggta?cgcttgcagc?aactgtttct?1560

tcaggtggtt?ctgtagccat?ggcagcagtt?atggctggag?gaatggtgcc?accacttgca?1620

atctttgtcg?caactcttct?tttcaaagat?aaatttacta?aggaagaacg?taactctggt?1680

ttgacaaaca?tcatcatggg?cttgtcattt?atcactgagg?gagcgattcc?atttggtgcc?1740

gctgacccag?ctcgtgcgat?tccaagcttc?atccttggtt?cagcagtagc?aggtggactc?1800

gttggtctta?ctggtatcaa?actcatggcg?ccacacggag?gaatcttcgt?tatcgccctt?1860

acttcaaatg?ctctccttta?cctcgtttct?gtcttggtag?gagcaatcgt?aagtggtgtg?1920

gtttatggtt?acctacgcaa?accacaagca?taa 1953

<210>308

<211>2304

<212>DNA

＜213〉streptococcus pneumoniae

<400>308

atggcaaaca?agaatacaag?tacaacaaga?cggagaccgt?ctaaagcaga?actggaaaga?60

aaagaagcga?ttcaacgaat?gttgatttcg?ttaggaattg?cgattttatt?gattttcgca?120

gccttcaaat?taggggctgc?aggtataacc?ctttataatt?taattcgctt?gctagtgggt?180

agcctagctt?atctggcgat?attcggccta?ttaatctatc?tcttcttttt?caagtggata?240

cgaaaacagg?aaggactctt?atctggcttt?ttcaccatat?ttgctggctt?actcttgatt?300

tttgaggcct?acttggtttg?gaaatatggt?ttggacaagt?ccgttctaaa?agggaccatg?360

gctcaggttg?tgacagatct?gactggtttt?cgaacgacta?gctttgctgg?agggggcttg?420

atcggggtcg?ctctttatat?tccaacagcc?tttctctttt?caaatatcgg?aacttacttt?480

attggttcta?tcttgatttt?agtgggttct?ctcctagtca?gcccttggtc?tgtttacgat?540

attgctgaat?ttttcagtag?aggctttgcc?aaatggtggg?aagggcacga?gcgtcgaaaa?600

gaggaacgct?ttgtcaaaca?agaagaaaaa?gctcgccaaa?aggctgagaa?agaggctaga?660

ttagaacaag?aagagactga?aaaagcctta?ctcgatttgc?ctcctgttga?tatggaaacg?720

ggtgaaattc?tgacagagga?agctgttcaa?aatcttccac?ctattccaga?agaaaagtgg?780

gtggaaccag?aaatcatcct?gcctcaagct?gaacttaaat?tccctgaaca?ggaagatgac?840

tcagatgacg?aagatgttca?ggtcgatttt?tcagccaaag?aagcccttga?atacaaactt?900

ccaagcttac?aactctttgc?accagataaa?ccaaaagatc?agtctaaaga?gaagaaaatt?960

gtcagagaaa?atatcaaaat?cttagaagca?acctttgcta?gctttggtat?taaggtaaca?1020

gttgaacggg?ccgaaattgg?gccatcagtg?accaagtatg?aagtcaagcc?ggctgttggt?1080

gtaagggtca?accgcatttc?caatctatca?gatgacctcg?ctctagcctt?ggctgccaaa?1140

gatgtccgga?ttgaagcacc?aatccctggg?aaatccctaa?tcggaattga?agtgcccaac?1200

tccgatattg?ccactgtatc?tttccgagaa?ctatgggaac?aatcgcaaac?gaaagcagaa?1260

aatttcttgg?aaattccttt?agggaaggct?gttaatggaa?ccgcaagagc?ttttgacctt?1320

tctaaaatgc?cccacttgct?agttgcaggt?tcaacgggtt?cagggaagtc?agtagcagtt?1380

aacggcatta?ttgctagcat?tctcatgaag?gcgagaccag?atcaagttaa?atttatgatg?1440

gtcgatccca?agatggttga?gttatctgtt?tacaatgata?ttccccacct?cttgattcca?1500

gtcgtgacca?atccacgcaa?agccagcaag?gctctgcaaa?aggttgtgga?tgaaatggaa?1560

aaccgttatg?aactctttgc?caaggtggga?gttcggaata?ttgcaggttt?taatgccaag?1620

gtagaagagt?tcaattccca?gtctgagtac?aagcaaattc?cgctaccatt?cattgtcgtg?1680

attgtggatg?agttggctga?cctcatgatg?gtggccagca?aggaagtgga?agatgctatc?1740

atccgtcttg?ggcagaaggc?gcgtgctgca?ggtatccaca?tgattcttgc?aactcagcgt?1800

ccatctgttg?atgtcatctc?tggtttgatt?aaggccaatg?ttccatctcg?tgtagcattt?1860

gcggtttcat?caggaacaga?ctcccgtacg?attttggatg?aaaatggagc?agaaaaactt?1920

cttggtcgag?gagacatgct?ctttaaaccg?attgatgaaa?atcatccagt?tcgtctccaa?1980

ggctccttta?tctcggatga?cgatgttgag?cgcattgtga?acttcatcaa?gactcaggca?2040

gatgcagact?acgatgagag?ttttgatcca?ggtgaggttt?ctgaaaatga?aggagaattt?2100

tcggatggag?atgctggtgg?tgatccgctt?tttgaagaag?ctaagtcttt?ggttatcgaa?2160

acacagaaag?ccagtgcgtc?tatgattcag?cgtcgtttat?cagttggatt?taaccgtgcg?2220

acccgtctca?tggaagaact?ggagatagca?ggtgtcatcg?gtccagctga?aggtaccaaa?2280

cctcgaaaag?tgttacaaca?ataa 2304

<210>309

<211>528

<212>DNA

＜213〉streptococcus pneumoniae

<400>309

atgagttatt?ttaaaaaata?taaattcgat?aaatcccagt?tcaaacttgg?tatgcgaacc?60

tttaaaacag?gtattgctgt?ttttctagtt?ctcttgattt?ttggcttttt?tggctggaaa?120

ggtcttcaaa?ttggtgcttt?gacagccgtt?tttagcctga?gggagagttt?tgatgagagt?180

gttcattttg?ggacttcgcg?tattctagga?aatagtatcg?gtggactcta?tgccttggtc?240

ttcttcttat?taaatacctt?tttccacgaa?gccttttggg?tgaccttggt?agttgttcca?300

atctgcacca?tgttaaccat?tatgacaaat?gtagccatga?ataacaaagc?aggggttatt?360

ggtggtgtag?cagctatgtt?aatcattacc?ctatcaattc?caagtggtga?gacaattttg?420

tacgtgtttg?tgcgtgtatt?agaaacgttt?atgggagttt?ttgtcgcaat?tatcgtaaat?480

tacgatattg?atcgtattcg?tctcttttta?gagaaaaaag?aaaaataa 528

<210>310

<211>471

<212>DNA

＜213〉streptococcus pneumoniae

<400>310

atgaataaat?cagaacaccg?ccaccaactt?atacgcgctc?ttatcacaaa?aaacaagatt?60

catacacagg?ctgagttgca?agcccttctt?gctgagaacg?acattcaagt?aacccaggca?120

accctctcac?gcgacatcaa?aaatatgaac?ctatcaaaag?tccgcgaaga?agatagcgct?180

tattatgttc?ttaacaatgg?ttccatctca?aaatgggaaa?aacgtctcga?actctacatg?240

gaagacgccc?ttgtctggat?gcgcccagtt?caacaccaag?tcctactaaa?aacccttcct?300

ggactggctc?aatcctttgg?ttctatcatt?gatactttga?gcttccctga?cgctatcgct?360

accctttgtg?gtaatgatgt?ctgtcttatc?atctgtgaag?atgcagatac?tgctcaaaag?420

tgctttgaag?aactgaaaaa?attcgcccca?ccatttttct?ttgaagaata?a 471

<210>311

<211>1488

<212>DNA

＜213〉streptococcus pneumoniae

<400>311

atgaaaagta?taaaattaaa?tgctctatct?tacatgggaa?ttcgtgtctt?gaatattatt?60

tttcccatcc?taactggaac?ctatgtcgcg?cgtgtcttgg?accgaactga?ctatggttac?120

ttcaactcag?tcgacactat?tttgtcattt?ttcttgccct?ttgcaactta?tggtgtctat?180

aactacggtt?taagggctat?cagtaatgtc?aaggataaca?aaaaagatct?taacagaacc?240

ttttctagtc?ttttttattt?gtgcatcgct?tgtacgattt?tgaccactgc?tgtctatatc?300

ctagcctatc?ctctcttctt?tactgataat?ccaatcgtca?aaaaggtcta?ccttgttatg?360

gggattcaac?tcattgccca?gattttttca?atcgaatggg?tcaatgaagc?tctggaaaat?420

tacagttttc?tcttttacaa?aactgccttc?atccgtatcc?tgatgctggt?ctctattttc?480

ttatttgtta?aaaatgaaca?cgatattgtt?gtctatacac?ttgtgatgag?tttatcgacg?540

ctgattaact?acctgattag?ttatttttgg?attaaaagag?acatcaaact?tgttaaaatt?600

cacctaagtg?attttaaacc?actctttctc?cctctgacag?ccatgttagt?ctttgccaat?660

gccaatatgc?tcttcacttt?tttagatcgc?ctcttcctcg?ttaaaacagg?gattgatgtc?720

aacgttagtt?actataccat?agctcagcga?attgtgaccg?ttatagctgg?ggttgtaaca?780

ggtgcaattg?gagtgagtgt?gcctcgtctc?agttactatc?tggggaaagg?agacaaagaa?840

gcctatgttt?ctctggttaa?tagaggtagt?cgaatcttta?acttctttat?cattccactg?900

agttttggac?tcatggtttt?aggaccaaat?gccatcctac?tttacggtag?tgaaaaatat?960

atcggaggcg?gcatcttgac?ctctctcttc?gcttttcgta?cgattatcct?ggccttagat?1020

accattcttg?gttcccaaat?tctctttacc?aatggctatg?aaaaacgtat?cacagtctat?1080

acagtctttg?ctgggctact?caatttgggc?ttgaatagtc?tccttttttt?caaccatatc?1140

gtggctcctg?aatactactt?actgacaact?atgctatcag?agacttctct?acttgttttc?1200

tatatcattt?tcatccatag?aaaacaactc?atccacttgg?gacatatctt?tagctatact?1260

gttcgatact?ctctcttttc?actttccttt?gtagcaattt?atttcctgat?taatttcgtg?1320

tatcctgtag?atatggtcat?taatttgcca?tttttgatta?atactggttt?gattgtcttg?1380

ctatcagcta?tctcttatat?tagtctactt?gtcttcacaa?aagatagcat?tttctatgaa?1440

tttttaaacc?atgtcctagc?cttaaaaaat?aaatttaaaa?aatcatag 1488

<210>312

<211>804

<212>DNA

＜213〉streptococcus pneumoniae

<400>312

atgaaacaac?taaccgttga?agatgccaaa?caaattgaat?tagaaatttt?ggattatatt?60

gatactctct?gtaaaaagca?caatatcaac?tatattatta?actacggtac?tctgattggg?120

gcggttcgac?atgagggctt?tatcccttgg?gacgacgata?ttgatctgtc?catgcctaga?180

gaagactacc?aacgatttat?taacattttt?caaaaggaaa?aaagcaagta?taagctccta?240

tccttagaaa?ctgataagaa?ctactttaac?aactttatca?agataaccga?cagtacgact?300

aaaattattg?atactcgaaa?tacaaaaacc?tatgagtctg?gtatctttat?cgatattttc?360

cctatagatc?gctttgatga?tcctaaggtc?attgatactt?gttataaact?ggaaagcttc?420

aaactgctgt?ctttcagtaa?acataaaaat?attgtctata?aggatagcct?tttaaaagat?480

tggatacgaa?cagccttctg?gttactcctt?cgaccggttt?ctcctcgtta?ttttgcaaat?540

aaaatcgaga?aagaaattca?aaaatatagt?cgtgaaaatg?ggcaatatat?ggcttttatc?600

ccttcaaaat?ttaaggaaaa?ggaagtcttc?ccaagtggta?cctttgataa?aacaatcgat?660

ttaccctttg?agaatttaag?ccttcctgca?cctgaaaaat?ttgatactat?tttgacacaa?720

ttttatggag?attatatgac?cctaccacca?gaagaaaaac?gcttctacag?tcatgaattt?780

cacgcttata?aattggagga?ttag 804

<210>313

<211>1527

<212>DNA

＜213〉streptococcus pneumoniae

<400>313

atgataaaaa?tcaatcatct?aaccatcaca?caaaacaaag?atttacgaga?tcttgtatct?60

gacctaacca?tgaccatcca?agacggggaa?aaggttgcta?ttattggtga?agaaggaaat?120

ggcaaatcaa?ccttacttaa?aattttaatg?ggggaagctt?tgtctgattt?cactatcaag?180

ggaaacatcc?aatctgacta?tcagtcactg?gcctacattc?ctcaaaaagt?ccctgaggac?240

ctaaaaaaga?aaactttaca?cgactacttc?tttttagatt?ctattgattt?agactacagt?300

atcctctatc?gtttggcgga?ggaattgcat?tttgatagca?atcgtttcgc?aagtgaccaa?360

gagattggca?atctatcagg?gggcgaagct?ttgaaaattc?agcttatcca?tgagttagcc?420

aaaccctttg?agattctatt?tttagatgaa?ccttcaaatg?acctagacct?tgagacagtt?480

gattggctaa?aaggccagat?tcaaaagacc?aggcaaaccg?ttattttcat?ttcccatgat?540

gaagactttc?tttctgaaac?ggcagacact?attgttcact?tgcgactggt?caaacaccgt?600

aaagaagcgg?aaacgctagt?agagcattta?gactatgata?gctatagtga?gcagagaaag?660

gctaattttg?ccaaacaaag?tcagcaagct?gctaacaacc?aaagagccta?cgataaaacc?720

atggaaaaac?atcggagagt?taagcaaaat?gtagaaactg?cgcttcgagc?taccaaagat?780

agtactgccg?gtcgcctatt?ggctaaaaag?atgaaaactg?tcctctcaca?agaaaaacgc?840

tacgaaaagg?cagctcagtc?catgactcaa?aagccacttg?aagaggaaca?aatccaactt?900

ttcttttcag?acatccaacc?attaccagct?tctaaagtct?tagtccaact?ggaaaaagaa?960

aatttgtcca?ttgacgaccg?agttttggtt?caaaaactac?aactaactgt?ccgtggccaa?1020

gaaaaaatcg?gtattatcgg?gccaaatggt?gttgggaaat?caactctgtt?agccaagtta?1080

cagagacttc?tgaatgataa?aagagagatt?tcacttggtt?ttatgccaca?agattaccac?1140

aaaaaactgc?aattggattt?atccccaata?gcctatctca?gtaaaactgg?ggaaaaagag?1200

gaactacaga?aaatccaatc?tcacctagct?agtctcaatt?tcagttatcc?agaaatgcag?1260

catcaaattc?gctccttatc?tggcggacaa?cagggaaaac?tcctgctttt?ggatttagtc?1320

ctgcgcaaac?caaactttct?cctgctggat?gaacccacac?gaaacttttc?tcccacttct?1380

caaccccaaa?tcagaaaact?ctttgctacc?tatccaggcg?gtctcatcac?tgtttcgcat?1440

gaccgtcgtt?tcttaaaaga?agtctgctcg?atcatctatc?gcatgacaga?acacggtttg?1500

aagctagtta?atttagaaga?tttataa 1527

<210>314

<211>714

<212>DNA

＜213〉streptococcus pneumoniae

<400>314

atgaaaccaa?aaacatttta?caacttgctt?gccgagcaga?atcttccact?ttcggaccag?60

caaaaagaac?aatttgaacg?ttattttgag?ctcttggtcg?agtggaatga?gaagattaat?120

ttgacggcga?ttacggacaa?ggaagaagtt?tatctcaaac?atttttacga?ttcgattgca?180

cccattcttc?aaggtttgat?tcccaatgaa?actatcaaac?ttcttgatat?cggggctggg?240

gcaggatttc?ctagtctacc?aatgaaaatt?ctctatccgg?agttagatgt?gaccattatt?300

gattcactca?ataagcgcat?caacttccta?caactcttgg?ctcaagaact?ggatttgaac?360

ggagttcatt?tctaccacgg?acgtgccgaa?gattttgccc?aagacaagaa?cttccgtgct?420

caatatgatt?ttgtaacagc?tcgtgcggtt?gcccgtatgc?aggtcctatc?tgaattgact?480

attccctacc?ttaaggttgg?tggcaaacta?ttagcactca?aggctagcaa?tgcgcctgag?540

gaattattag?aagctaagaa?tgccctcaat?ctccttttta?gtaaggtcga?agacaatctc?600

agctacgccc?taccgaatag?agatccgcgc?tatatcacag?tggtagaaaa?gaaaaaagaa?660

acaccaaata?aatatccacg?taaggctggt?atgccaaata?aacgcccact?ttaa 714

<210>315

<211>807

<212>DNA

＜213〉streptococcus pneumoniae

<400>315

atgagtatta?aactaattgc?cgttgatatc?gacggaaccc?ttgtcaacag?ccaaaaggaa?60

atcactcctg?aagttttttc?tgccatccaa?gatgccaaag?aagctggtgt?caaagtcgtg?120

attgcaactg?gccgccctat?cgcaggcgtt?gccaaacttc?tagacgactt?gcagttgaga?180

gacgaggggg?actatgtggt?aaccttcaac?ggtgcccttg?tccaagaaac?tgctacagga?240

catgagatta?tcagcgaatc?cttgacttat?gaggattatc?tagatatgga?attcctcagt?300

cgcaagctcg?gtgtccacat?gcatgccatt?accaaggacg?gtatctatac?tgcaaatcgc?360

aatatcggaa?aatacactgt?acacgaatca?accctcgtca?gcatgcctat?cttctaccgt?420

acccctgaag?aaatggctgg?caaagaaatt?gttaaatgta?tgtttatcga?tgaaccagaa?480

attctcgatg?ctgcgattga?aaaaattcca?gcagaatttt?acgagcgcta?ctccatcaac?540

aaatctgctc?ctttctacct?cgaactcctt?aaaaagaatg?tagacaaggg?ttcagccatt?600

actcacttgg?ctgaaaaact?cggattgacc?aaagatgaaa?ccatggcaat?cggtgatgaa?660

gaaaatgacc?gtgccatgct?ggaagtcgtt?ggaaaccccg?ttgtcatgga?aaatggaaat?720

ccagaaatca?aaaaaatcgc?caaatacatc?accaaaacaa?atgacgaatc?cggcgttgcc?780

catgccatcc?gaacatgggt?actgtaa 807

<210>316

<211>561

<212>DNA

＜213〉streptococcus pneumoniae

<400>316

atgacttgga?ttattcttgg?agttatcgct?cttattgtta?tttttgtgat?tgttagctat?60

aacggtttgg?ttaaaaatcg?tatgcaaacc?aaggaggctt?ggagtcagat?tgatgttcag?120

ttgaaacgtc?gcaatgacct?cttgccaaac?ttgattgaga?ctgtaaaagg?ttatgccaaa?180

tatgaaggtt?ctacccttga?aaaggtggca?gaactacgta?accaagtggc?ggcagcgact?240

tcaccagcag?aagctatgaa?agccagtgat?gccctcactc?gtcaggtttc?aggtattttt?300

gcagttgcag?aaagctatcc?agatttgaaa?gctagtgcta?actttgttaa?attgcaagag?360

gagttgacaa?acacagaaaa?taaaatttct?tactctcgtc?aactctataa?cagtgttgtc?420

agcaactaca?atgtaaaatt?agaaactttc?ccgagcaata?ttatcgctgg?aatgtttgga?480

tttaaagcgg?cagatttcct?tcaaacacct?gaagaggaaa?agtcggttcc?taaagttgat?540

tttagcggtt?taggtgacta?a 561

<210>317

<211>900

<212>DNA

＜213〉streptococcus pneumoniae

<400>317

atgttgtttg?atcaaattgc?aagcaataaa?cgaaaaacct?ggattttgtt?gctggtattt?60

ttcctactct?tagctcttgt?tggttatgcg?gttggttatc?tctttataag?atctggactt?120

ggtggtttgg?ttattgcact?gattatcggc?tttatctacg?ctttgtctat?gatttttcaa?180

tcgacagaga?ttgtcatgtc?catgaatgga?gcgcgtgagg?tggatgagca?aacggcacca?240

gacctctacc?atgtagtgga?agatatggct?ctggtcgctc?agattcctat?gccccgtgtt?300

ttcatcattg?atgatccagc?cttaaatgcc?tttgcgacag?gttctaatcc?tcaaaatgcg?360

gctgttgctg?cgacttcagg?tctactagct?atcatgaatc?gtgaagaact?agaagctgtt?420

atgggacatg?aagtcagtca?tattcgtaat?tatgatatcc?gtatttcgac?tattgcagtt?480

gcccttgcta?gtgctatcac?catgctttct?agtatggcag?gtcgtatgat?gtggtggggt?540

ggagcaggtc?gcagacgaag?tgatgatgac?cgagatggaa?atggtcttga?aatcattatg?600

ctagtggttt?ccctactagc?tattgtactg?gcacctctcg?ctgcaacctt?ggttcagctc?660

gctatttctc?gtcagaggga?atttctggca?gatgcatcta?gtgtcgagct?gactcgcaat?720

ccccagggaa?tgattaatgc?cctagataag?ttggacaata?gcaaacctat?gagtcgccac?780

gtcgatgatg?ctagcagtgc?cctttatatc?aatgatccta?agaaaggtgg?ggggttccaa?840

aaactctttt?atacccaccc?acctatctca?gaacggattg?aacgtttaaa?acagatgtaa?900

<210>318

<211>543

<212>DNA

＜213〉streptococcus pneumoniae

<400>318

atgaaattaa?atattcaaga?aattcgtaag?cagtctgaag?gtttgaactt?tgaacaaacg?60

ttagatttag?ttgatgacct?gcgtgcacgt?aatcaagaaa?ttttagatgt?aaaagatatc?120

cttgcagttg?ggaaagtaca?atatgaagac?cgtatgtatt?tcttagatta?tcaactatct?180

tataccattg?ttcttgcttc?gagtcgcagt?atggagccag?ttgagttagt?tgaatcttat?240

ccagtcacgg?aagttttcat?ggaaggcgca?actaaccagc?tagatcaaga?agttttagat?300

gatgacttgg?tcttgcccat?cgaaaatggg?gagcttgacc?ttgctgagag?tgtatcagac?360

aatatcctgc?taaacattcc?tatcaaggtc?ttgacggctg?aagaagaagc?tggtcaagga?420

tttatctcag?gaaatgactg?gcaaatcatg?acagaggaag?aataccaagc?tcaaaaagca?480

gtaaagaaag?aagaaaacag?tccttttgct?ggcttacaag?gactatttga?cggagatgaa?540

taa 543

<210>319

<211>861

<212>DNA

＜213〉streptococcus pneumoniae

<400>319

atggagttat?ttatgaaaat?cacaaactat?gaaatctata?agttaaaaaa?atcaggtttg?60

accaatcaac?agattttgaa?agtgctagaa?tacggtgaaa?atgttgatca?ggagcttttg?120

ttgggtgata?ttgcagatat?ctcaggttgc?cgtaatccag?ccgtttttat?ggaacgttat?180

tttcagatag?acgatgcgca?tttgtcgaaa?gagtttcaaa?aatttccatc?tttctctatt?240

ttagatgact?gttatccttg?ggatttgagt?gaaatatatg?atgcgcctgt?acttttattt?300

tacaagggaa?atcttgacct?cctgaaattc?ccgaaggtag?cggtcgtggg?cagtcgtgct?360

tgtagcaaac?agggagctaa?gtcagttgaa?aaagtcattc?aaggcttgga?aaatgaactg?420

gttattgtca?gtggtctggc?caagggcatt?gacacagcag?ctcatatggc?agctcttcag?480

aatggcggaa?aaaccattgc?agtgattgga?acaggactgg?atgtgtttta?tcctaaagcc?540

aataaacgct?tgcaagacta?catcggcaat?gaccatctgg?ttctaagtga?atatggacct?600

ggtgaacaac?ctctgaaatt?tcattttcct?gcccgtaatc?gcatcattgc?tggactttgt?660

cgtggtgtga?ttgtagcaga?ggctaagatg?cgttcaggta?gtctcattac?gtgtgagcga?720

gcaatggaag?aaggacgcga?tgtctttgct?attcctggta?gcattttaga?tggactatca?780

gacggttgcc?atcatttgat?tcaagaagga?gcaaaattgg?tcaccagtgg?gcaagatgtt?840

cttgcggaat?ttgaatttta?a 861

<210>320

<211>534

<212>DNA

＜213〉streptococcus pneumoniae

<400>320

atgaaacgtc?aattagcctt?ggtcgtcttt?agtggtggtc?aagattcaac?aacctgcctt?60

ttctgggtca?tgcaacacta?tgaaacagtc?gaagctgtca?cctttgccta?cggccaacgt?120

catcacctcg?aaattcaaat?tactagagaa?atcgctaagg?aacagggcat?tcgtcaccat?180

atcctcgata?tgtctctgct?gggacaaatc?actgctcagc?cagactttgc?gacgattcat?240

atttcctaca?ttcctgacaa?gctctgtgtc?gagtcaaaat?ccctcaaact?atatctattt?300

agctaccgaa?accacggaga?tttccacgaa?aactgtatca?acaccatcgg?gaaagacttg?360

gtcaacttgc?tagaccctcg?ctatttagaa?gtctggggaa?aattcactcc?gcgcggtggc?420

atttcaatcg?acccctacta?caactacggt?aagcaaggaa?ctaagtatga?gggcttggca?480

gaacaacgcc?tcttccaaca?cgacctttat?ccagagaaaa?ttgacaaccg?ctaa 534

<210>321

<211>3711

<212>DNA

＜213〉streptococcus pneumoniae

<400>321

atgaccgaaa?cggtagaaga?taaagtaagt?cattcaatta?ctgggcttga?tatcctcaag?60

gggatagttg?ctgcgggagc?tgtcataagt?ggaaccgttg?caactcaaac?gaaggtattt?120

acaaatgagt?cagcagtact?tgaaaaaact?gtagagaaaa?cggatgcttt?ggcaacaaat?180

gatacagtag?ttctaggtac?gatatctaca?agtaattcag?cgagttcaac?tagtttgtca?240

gcttcagagt?cggcaagtac?atctgcatct?gagtcagcct?caaccagcgc?ttcgacctca?300

gcaagtacaa?gtgcatcaga?atcagcaagt?acatcggctt?cgacaagtat?ttctgcatca?360

tctactgtgg?taggttcaca?aacagctgcc?gctacagaag?caactgctaa?gaaggtcgaa?420

gaagatcgta?agaaaccagc?tagtgattat?gtagcatcag?ttacaaatgt?caatctccaa?480

tcttatgcta?agcgacgcaa?gcgttcagtg?gattccatcg?agcaattgct?ggcttctata?540

aaaaatgctg?ctgttttttc?tggcaatacg?attgtaaatg?gcgcccctgc?aattaatgca?600

agtctaaaca?ttgctaaaag?tgagacaaaa?gtttatacag?gtgaaggtgt?agattcggta?660

tatcgtgttc?caatttacta?taaattgaaa?gtgacaaatg?atggttcaaa?attgaccttt?720

acctatacgg?ttacgtatgt?gaatcctaaa?acaaatgatc?ttggtaatat?atcaagtatg?780

cgtcctggat?attctatcta?taattcaggt?acttcaacac?aaacaatgtt?aacccttggc?840

agtgatcttg?gtaaaccttc?aggtgtaaag?aactacatta?ctgacaaaaa?tggtagacag?900

gttctatcct?ataatacatc?tacaatgacg?acgcagggta?gtgggtatac?ttggggaaat?960

ggtgcccaaa?tgaatggttt?ctttgctaag?aaaggatatg?gattaacatc?atcttggact?1020

gtaccaatta?ctggaacgga?tacatccttt?acatttaccc?cttacgctgc?tagaacagat?1080

agaattggaa?ttaactactt?caatggtgga?ggaaaggtag?ttgaatctag?cacgaccagt?1140

cagtcacttt?cacagtctaa?gtcactctca?gtaagtgcta?gtcaaagcgc?ctcagcttca?1200

gcatcaacaa?gtgcgtcggc?ttcagcatca?accagtgcct?cggcttcagc?gtcaaccagt?1260

gcgtcagctt?cagcaagtac?cagtgcttca?gtctcagcat?caacaagtgc?ttcagcctca?1320

gcatcgacaa?gtgcctcggc?ttcagcaagc?acatcagcat?ctgaatcagc?gtcaaccagt?1380

gcttcggctt?cagcaagtac?cagtgcttca?gcttcagcat?caaccagcgc?ctcggcctca?1440

gcaagcacct?cagcttctga?atcggcctca?accagcgcct?cggcctcagc?aagcacctca?1500

gcttctgaat?cggcctcaac?cagcgcctca?gcctcagcat?caacgagtgc?ttcggcttca?1560

gcaagcacaa?gcgcctcggg?ttcagcatca?acgagtacgt?cagcttcagc?gtcaaccagt?1620

gcttcagcct?cagcatcaac?aagtgcgtca?gcctcagcaa?gtatctcagc?gtctgaatcg?1680

gcatcaacga?gtgcgtctga?gtcagcatca?acgagtacgt?cagcctcagc?aagcacctca?1740

gcttctgaat?cggcctcaac?cagtgcgtca?gcctcagcat?cgacaagcgc?ctcagcttca?1800

gcaagtacca?gtgcttcagc?ctcagcgtcg?acaagtgcgt?cggcctcaac?cagtgcatct?1860

gaatcggcat?caaccagtgc?gtcagcctca?gcaagtacta?gtgcatcggc?ttcagcatca?1920

accagtgcct?cggcttcagc?gtcaaccagt?gcgtcagctt?cagcaagtac?cagtgcttca?1980

gtctcagcat?caacaagtgc?ttcagcctca?gcatcgacaa?gtgcctcggc?ttcagcaagc?2040

acatcagcat?ctgaatcagc?gtcgacaagc?gcctcagctt?cagcaagtac?cagtgcgtca?2100

gcttcagcat?caaccagcgc?ctcggcctca?gcaagcacct?cagcttctga?atcggcctca?2160

accagcgcct?cggcctcagc?aagcacctca?gcttctgaat?cggcctcaac?cagcgcctca?2220

gcctcagcat?caacgagtgc?ttcggcttca?gcaagcacaa?gcgcctcggg?ttcagcatca?2280

acgagtacgt?cagcttcagc?gtcaaccagt?gcttcagcct?cagcatcaac?aagtgcgtca?2340

gcctcagcaa?gtatctcagc?gtctgaatcg?gcatcaacga?gtgcgtctga?gtcagcatca?2400

acgagtacgt?cagcctcagc?aagcacctca?gcttctgaat?cggcctcaac?cagtgcgtca?2460

gcctcagcat?cgacaagcgc?ctcagcttca?gcaagtacca?gtgcttcagc?ctcagctcga?2520

caagtgcgtc?ggcctcaacc?agtgcatctg?aatcggcatc?aaccagtgcg?tcagcctcag?2580

caagtactag?tgcatcagct?tcagcatcaa?cgagtgcatc?ggcttcagca?tcaaccagtg?2640

cctcggcttc?agcgtcaacc?agtgcgtcag?cttcagcaag?taccagtgct?tcagtctcag?2700

catcaacaag?tgcttcagcc?tcagcatcga?caagtgcctc?ggcttcagca?agcacatcag?2760

catctgaatc?agcgtcgaca?agcgcctcag?cttcagcaag?taccagtgcg?tcagcctcag?2820

cgtcgacaag?tgcgtcagcc?tcagcaagta?ctagtgcatc?agcttcagca?tcaacgagtg?2880

catcggcttc?ggcgtcaacc?agtgcatcag?agtcagcaag?taccagtgcg?tcagcttccg?2940

catcaacaag?tgcctcggct?tcagcaagca?ccagtgcgtc?ggcttcagca?agtactagcg?3000

cctcagcctc?agcctcaacc?agtgcgtcag?cctcagcaag?tatctcagcg?tctgaatcgg?3060

catcaacgag?tgcgtccgct?tcagcaagta?ctagcgcctc?agcctcagcg?tcaacaagtg?3120

catcggcttc?agcgtcaacg?agtgcgtctg?aatcggcatc?aacgagtgcg?tccgcttcag?3180

caagtactag?cgcctcagcc?tcagcgtcaa?caagtgcatc?ggcttcagca?tcaacgagtg?3240

cgtccgcttc?agcaagtact?agcgcctcag?cctcagcgtc?aacaagtgca?tcggcttcag?3300

cgtcaacgag?tgcgtctgag?tcagcatcaa?cgagtgcgtc?agcctcagca?agcacatcag?3360

cttctgaatc?tgcatcaacc?agtgcgtcag?cctcagcatc?gacaagcgcc?tcagcttcag?3420

caagtaccag?tgcgtcagcc?tcagcgtcga?caagtgcgtc?ggcttcagca?agtaccagtg?3480

cgtcagcctc?agcaagtacc?agtgcgtcag?cctcagcgtc?gacaagtgcg?tcggcctcaa?3540

ccagtgcatc?tgaatcggca?tcaaccagtg?cgtcagcctc?agcaagtact?agtgcatcag?3600

cttcagcatc?aacgagtgca?tcggcttcag?catcaaccag?tgcatcagag?tcagcaagta?3660

ccagtgcgtc?agttccgcat?caacaagtgc?ctcggcttca?gcaagtacta?g 3711

<210>322

<211>1350

<212>DNA

＜213〉streptococcus pneumoniae

<400>322

atgggggtcg?aaacttggtt?ttattctagc?atctgctggc?tggccatcgg?gcttggttcc?60

gtttggaagt?ttccctacat?gactgctgct?aatggcggtg?gaggcttttt?actaatcttt?120

ctcatttcca?ctattttaat?cggtttccct?ctcctgctgg?ctgagtttgc?ccttggccgt?180

agtgctggcg?tttccgctat?caaaaccttt?ggaaaactgg?gcaagaataa?caagtacaac?240

tttatcggtt?ggattggcgc?ctttgccctc?tttatcctct?tatcttttta?cagtgttatc?300

ggaggatgga?ttctagtcta?tctaggtatt?gagtttggga?aattgttcca?acttggtgga?360

acgggtgatt?atgctcagtt?atttacttca?atcatttcaa?atccagccat?tgccctagga?420

gctcaagcgg?cctttatcct?attgaatatc?ttcattgtat?cacgtggggt?tcaaaaaggg?480

attgaaagag?cttcgaaagt?catgatgccc?ctgctcttta?tcgtctttgt?ttttatcatc?540

ggtcgctctc?tcagtttgcc?aaatgccatg?gaaggggttc?tttacttcct?caaaccagac?600

ttttcaaaac?tgactagcac?tggtctcctc?tatgctctgg?gacaatcttt?ctttgccctc?660

tcactagggg?ttacagtcat?gttgacctat?gcttcttact?tagacaagaa?aaccaatcta?720

gtccagtcag?gaatctccat?cgtagccatg?aatatctcga?tatccatcat?ggcaggtcta?780

gccattttcc?aagctcgatc?ccccttcaat?atccagtctg?aagggggacc?cagcctgctc?840

tttatcgtct?tgcctcaact?ctttgacaag?atgccttttg?gaaccatttt?ctacgtcctc?900

ttcctcttgc?tcttcctttt?tgcgacagtc?actttttctg?tcgtgatgct?ggaaatcaat?960

gtagacaata?tcaccaacca?ggataacagc?aaacgtgcca?aatggagtgt?tattttagga?1020

attttgacct?ttgtctttgg?cattccttca?gccctatctt?acggtgtcat?ggcggatgtt?1080

cacatttttg?gtaagacctt?ctttgacgct?atggacttct?tggtttccaa?tctcctcatg?1140

ccatttggag?ctctctacct?ttcacttttt?acaggctata?tctttaaaaa?ggctcttgca?1200

atggaggaac?tccatctcga?tgaaagagca?tggaaacaag?gactgttcca?agtctggctc?1260

ttccttcttc?gtttcttcgt?ttcgtcattc?caatcatcat?cattgtggtc?ttcattgccc?1320

aatttatgta?atcaaaaagg?acttgagtag 1350

<210>323

<211>561

<212>DNA

＜213〉streptococcus pneumoniae

<400>323

atgttgaaaa?aatggcagtt?aaaagatgtt?atcttgcttg?ctttcttgtc?tatctttttt?60

ggtggggttt?tcgttggttc?aggatatgtg?tataatattc?tcagtctact?cttaacacct?120

cttggtttgc?aggcctttgc?caatgaaatc?ctcttcggtc?tctggtgtat?ggctgcgccc?180

attgctgcca?tctttgttcc?gagagtcgga?agtgcaacga?ttggagaagt?gctagctgcg?240

cttgctgaag?tcctttatgg?tagccaattt?ggtctaggag?ctcttttgtc?tggctttgtt?300

caaggtttgg?gaagtgaatt?tggttttatc?gtaactaaga?atcgctatga?aagttggctc?360

tctctaactg?ctaatagtat?tgggattacg?cttgttagct?ttgtctatga?atacattaag?420

ttaggttact?acgccttttc?ccttccgttt?gtcctttcct?tgcttgtggt?acgttttatt?480

tctgtttatt?tcttctgtac?catcttggtt?cgtgccattg?tcaaactcta?tcatcagttt?540

gcaactggag?gaaaagcata?g 561

<210>324

<211>651

<212>DNA

＜213〉streptococcus pneumoniae

<400>324

atggtcaaag?tagcaaccca?gacaccgatt?atcagtctct?tcttgctgat?tttatccttg?60

gaaacatctt?tcattccttc?gattgctctg?actctttcgg?tagtcgcatt?ttgtattctc?120

tttatgctct?attaccgtcg?atttaaaatg?ttagcttgga?tgatcatact?tgccatttta?180

ccatcttttg?ccaactactg?ggcagttcag?ttacacggag?atgcttcaca?ggcagtcatg?240

cttggaacga?gggcctttgt?gacagtttgt?atcggccttg?tctttgtttc?ctctgtttca?300

ctaaaagagc?ttctcttgta?cttggctcaa?aaggggctat?cacgctcttg?gtcctatgcc?360

ttgattgtgg?tattcaattc?ttttcctctc?attcagcaag?aaatcaagtc?cctcaaagaa?420

gcttgcctat?tacgtggtca?agaactacat?ttttggtcgc?ccttgattta?cagtaaggtt?480

ctgatgacag?tctttaggtg?gcgccatctt?tacctgagag?ctctatctgc?tcacggatat?540

gacgaacatg?cacagttgaa?gaatagctat?cggacttttt?atattcctaa?aaaaacaaaa?600

ttaatctacc?tgcttttctt?tttattgctt?caaaccagtc?tatttttata?a 651

<210>325

<211>525

<212>DNA

＜213〉streptococcus pneumoniae

<400>325

atgagaaagc?accaattaca?agttcacaaa?ttaaccattt?tatctatgat?gattgccctt?60

gatgtagtcc?ttacacctat?ctttcgaatt?gagggaatgg?caccgatgtc?cagtgtagtc?120

aatattctag?caggaatcat?gatgggacct?gtttatgcct?tggctatggc?tacagtcaca?180

gcctttatcc?gtatgacgac?tcaagggatt?ccgcctttag?ctctcacagg?agcgactttt?240

ggagcccttc?tagcaggtct?cttttataag?tacggtcgaa?aatttcacta?ttctgctcta?300

ggagagattt?tgggaacagg?tattattggt?tccattgttt?cctatcctgt?tatggtactc?360

tttacaggat?cagctgctaa?gcttagctgg?tttatctaca?cgcctcgatt?tttcggagca?420

accttgattg?gtacagcgat?ttcctttatt?gcctttcgat?ttttaatcaa?gcaggaattc?480

tttaaaaaag?tgcagggata?tttctttagt?gaaaggatag?actga 525

<210>326

<211>804

<212>DNA

＜213〉streptococcus pneumoniae

<400>326

atgcaggaat?ttacaaatcc?ctttcctata?ggctctagtt?ccctcattca?ctgcattacc?60

aatgagattt?cttgtgagat?gctggcaaat?gggattttgg?ctctgggatg?caaacctgtc?120

atggcagatg?attcccgtga?agttcttgat?tttactaagc?aaagtcaggc?tctcttcatc?180

aatttggggc?atttgtcagc?tgagaaggaa?aaagcaatcc?gcatggcagc?ttcgtatgca?240

aaccaatctt?ctctcccgat?ggtagtagat?gcggttggcg?taacgacttc?atccattcgt?300

aagagcttag?ttaaagacct?tttagactat?agacctacgg?tccttaaagg?aaacatgtca?360

gaaattcgaa?gtcttgttgg?attaaagcac?cacggcgttg?gggtcgatgc?gagtgctaaa?420

gatcaagaaa?cggaggattt?gcttcaagtc?ttgaaagact?ggtgtcagac?ctatcctggt?480

atgtctttct?tagtcacagg?tcccaaggac?ctcgtcgttt?cgaaaaatca?ggtcgctgta?540

ctgggaaatg?gctgtactga?attagactgg?ataacaggga?caggagactt?ggttggagcc?600

ttaacagctg?tttttctcag?ccaaggaaag?actggttttg?aagcttcttg?cttagcagtc?660

tcttatctca?atatcgctgc?tgagaaaata?gttgttcaag?gaatgggatt?ggaagaattt?720

cgttaccaag?tactcaatca?gctttcgctc?ctaagaagag?atgaaaattg?gctagatacc?780

atcaaaggag?aggtttatga?atag 804

<210>327

<211>834

<212>DNA

＜213〉streptococcus pneumoniae

<400>327

atgaaccata?aaatcgcaat?tttatcagat?gttcatggca?atgcgacggc?gctagaagca?60

gtgattgcag?atgctaaaaa?tcaaggggcc?agtgaatatt?ggcttctggg?agatattttt?120

cttcctggtc?caggcgcaaa?tgacttagtc?gccctgctaa?aggaccttcc?tatcacagca?180

agtgttcgag?gcaattggga?tgatcgtgtc?cttgaggctt?tagatgggca?atatggctta?240

gaagacccac?aggaagttca?gctcttgcgt?atgacacagt?atttgatgga?gcgaatggat?300

cctgcaacga?ttgtctggct?acgaagcttg?cctttgctgg?aaaagaaaga?aattgacgga?360

ttgcgctttt?ctatctctca?taatttacct?gacaaaaact?atggtggtga?cttgctagtt?420

gagaatgata?cagagaaatt?tgaccaactg?ctagatgcgg?aaacggacgt?ggcagtttat?480

ggtcatgttc?acaagcagtt?gcttcgttat?ggaagtcaag?ggcaacaaat?catcaatcca?540

gggtcgattg?gcatgcccta?ttttaattgg?gaggcgttaa?aaaatcaccg?ttcccagtat?600

gccgtgatag?aagttgaaga?tggggaatta?ctcaatatcc?aatttcgtaa?agttgcttat?660

gattacgaag?ctgagttaga?attggccaag?tccaaggggc?ttccctttat?cgaaatgtat?720

gaagaactgc?gtcgtgacga?taactatcag?gggcacaatc?tggaattatt?agccagctta?780

atagaaaagc?atgggtatgt?agaggatgtg?aagaattttt?ttgatttttt?gtaa 834

<210>328

<211>726

<212>DNA

＜213〉streptococcus pneumoniae

<400>328

atgaatgtaa?atcagattgt?acggattatt?cctactttaa?aagctaataa?tagaaaatta?60

aatgaaacat?tttatattga?aacccttgga?atgaaggcct?tgttagaaga?atcggccttt?120

ctgtcactag?gtgaccaaac?gggtcttgaa?aagctggttt?tagaagaagc?tcccagtatg?180

cgtactcgta?aggtagaggg?aagaaaaaaa?ctagctagat?tgattgtcaa?ggtggaaaat?240

cccttagaaa?ttgaaggaat?cttatctaaa?acagattcga?ttcatcgatt?atataaaggt?300

caaaatggct?acgcttttga?aattttctca?ccagaagatg?atttgatttt?gattcatgcg?360

gaagatgaca?tagcaagtct?agtagaagta?ggagaaaagc?ctgaatttca?aacagatttg?420

gcatcaattt?ctttaagtaa?atttgagatt?tctatggaat?tacatctccc?aactgatatc?480

gaaagtttct?tggaatcatc?tgaaattggg?gcatcccttg?attttattcc?agctcagggg?540

caggatttga?ctgtggacaa?tacggttacc?tgggacttat?ctatgctcaa?gttcttggtc?600

aatgaattag?acatagcaag?tcttcgccag?aagtttgagt?ctactgaata?ttttattcct?660

aagtctgaaa?aattcttcct?tggtaaagat?agaaataatg?ttgaattgtg?gtttgaagaa?720

gtatga 726

<210>329

<211>936

<212>DNA

＜213〉streptococcus pneumoniae

<400>329

atgaagtgga?ccaagattat?taaaaaaata?gaagaacaaa?tcgaggcagg?gatttatccc?60

ggagcctctt?ttgcgtattt?taaggacaat?caatggacag?agttctattt?aggccagagt?120

gacccagagc?atggcttgca?gactgaggca?ggactagttt?atgacctagc?tagtgtcagc?180

aaggttgttg?gggttggcac?agtttgtacc?ttcttgtggg?aaataggtca?attagatatt?240

gatagactgg?taatagattt?tttacctgag?agtgattatc?cagacatcac?tattcgccag?300

ctcttgactc?atgcaacaga?ccttgatcct?tttattccta?atcgtgatct?tttaacagcc?360

cctgaattaa?aggaagcgat?gtttcatctc?aacagacgaa?gtcagccagc?ctttctttat?420

tcggatgtcc?attttttgct?gttgggcttt?attttggaaa?gaatttttaa?tcaagatttg?480

gatgtgattt?taaaggatca?agtctggaaa?ccttggggaa?tgacggaaac?taagtttggg?540

ccagttgagc?ttgctgttcc?aacagttaga?ggtgtagagg?caggcatagt?gcatgatccc?600

aaggctcgtc?tcctgggtag?acatgctggg?agtgctggtt?tattttcgac?tataaaggat?660

ttacaaatct?ttttagaaca?ctatttagca?gatgattttg?caagagactt?aaatcaaaat?720

ttttctcctt?tggatgacaa?ggaacgttct?ttagcatgga?atttggaagg?agattggcta?780

gaccatacgg?gctatacagg?tacctttatc?atgtggaatc?gtcagaagca?agaagccact?840

attttcctat?cgaatcgtac?ctatgaaaag?gacgagagag?ctcaatggat?attagaccgc?900

aatcaagtga?tgaacttgat?tcgcaaagaa?gagtaa 936

<210>330

<211>483

<212>DNA

＜213〉streptococcus pneumoniae

<400>330

atgatgaaga?agacttataa?tcatattttg?gtctggggag?tcattttcta?tagcatttgc?60

attgtctgtt?tttgctttac?tcctcaagaa?caatctaccg?tgggagtggg?aactccaggt?120

attcagcatc?ttggacgcct?ggtttttctt?ttgactcctt?tcaattctct?ctggaaactg?180

ggcgaagtga?gtgacattgg?acaattatgt?tggatttttt?tacaaaatat?cctcaatgtc?240

ttcttgtttt?ttcctctgat?tttccaactc?ctttatctat?ttccaaattt?gcggaaaaca?300

aaaaaggtcc?ttctttttag?ttttcttgtg?agtcttggaa?tcgagtgtac?gcaattaatc?360

ttggactttt?tctttgattt?caatcgcgtc?tttgagattg?atgatttgtg?gaccaacact?420

ttgggtggct?atctggcttg?gctcctttat?aaacgattac?ataaaaacaa?ggtaaggaat?480

taa?483

<210>331

<211>792

<212>DNA

＜213〉streptococcus pneumoniae

<400>331

atgaagattc?ctctcttaac?ttttgcaagg?cataaatttg?tttatgtctt?gcttactttg?60

ctttttcttg?ctttggttta?tcgtgatgtt?ttgatgactt?atttcttttt?tgatattcat?120

gcgcccgatc?tagctaaatt?cgatggacaa?gcaattaaaa?atgacttatt?aaaatcagca?180

ttagattttc?gtattctcca?gttcaatcta?ggtttttatc?aatcatttat?tattccaatc?240

atcattgttt?tgctaggttt?tcaatatatt?gagctgaaaa?ataaagtttt?acgattgagt?300

attggaagag?aagtgagtta?tcaagggtta?aaaagaaagt?tgactttgca?agttgcaagt?360

atcccttgtt?tgatatattt?agtgactgtg?ctgataattg?caattataac?ctatttcttt?420

gggacttttt?ctcctcttgg?atggaattct?ctattttctg?atggaagtgg?tttacaaaga?480

ctcctagatg?gagagataaa?aagctatttg?ttctttactt?gtgtcctact?aatcggtatt?540

ttcatcaatg?caatctattt?tttacaaata?gttgattatg?tggggaatgt?gactcgttcg?600

gcaatcacct?atttgatgtt?tctttggctt?ggttctatgc?tgctttatag?tgccttgcct?660

tactatatgg?ttcctatgac?gagtttgatg?caagctagct?atggggatgt?aagtttgatg?720

aaactcttta?ctccttatat?cctttatatt?gtcccttaca?tggtgcttga?aaaatatgaa?780

gataatgttt?aa 792

<210>332

<211>651

<212>DNA

＜213〉streptococcus pneumoniae

<400>332

atgaagataa?tgtttaagaa?ttttaacaat?attttgctaa?atagaaagat?tgttttacta?60

cttcgtatag?ttctgatgat?gattttgata?aaccatctat?tgtcaacagc?ggttcaaaag?120

caggatgctg?ttatcttttt?caagagagaa?ttgatttcaa?ttttttccta?taatgactat?180

tctgaagcga?atttagaaat?ccccaaacta?ttgttaaacc?tttcgctttt?catggtagga?240

tggctctctg?tcattttact?tgaaagtgat?ttggcagacc?attaccatca?cttgattcgc?300

tatcaatcaa?gctccttttt?cgattataca?aggaaacgat?tggttgtcat?ttctaaattt?360

tttactcaag?atttgtttgt?ctggtttctt?ggtttacttc?ctctaggaat?tcatttcaaa?420

acagtcgcac?ttttcttttt?acttgctcag?ttaatgatgt?tgtacttact?actgtcttat?480

ctgatagcac?tgattagtgc?gggcgctggt?ttttcctttt?ttctctattt?tttagcattt?540

gtgggacaag?aatggatgat?ggatcatatt?gtaacagtgt?atttagtact?cttaagttta?600

ttagttatgt?tgattgttag?tcgcttggaa?gagaaattta?agaaaggata?a 651

<210>333

<211>525

<212>DNA

＜213〉streptococcus pneumoniae

<400>333

atgggcaaag?gagagatggg?caaaggagtt?attggcttgg?agttcgactc?agaagtattg?60

gtcaacaagg?ctccaaccct?tcaattggca?aatggtaaaa?cagcgacttt?cctaacccag?120

tatgatagca?agaccttgtt?gtttgcagta?gataaggaag?atatcggaca?ggaaattatt?180

ggtatagcta?aaggaagcat?cgaaagtatg?cataatcttc?ctgtaaatct?agcaggtgcc?240

agagttcctg?gcggagtaaa?tggtagcaaa?gcagcggtgc?atgaagttcc?agaatttaca?300

gggggagtta?atggtacaga?gccagctgtt?catgaaatcg?cagagtataa?gggatctgat?360

tcgcttgtaa?ctcttactac?aaaaaaagat?tatacttaca?aagctcctct?tgctcagcag?420

gcacttcctg?aaacaggaaa?caaggagagt?gacctcctag?cttcactagg?actaacagct?480

ttcttccttg?gtctgtttac?gctagggaaa?aagagagaac?aataa 525

<210>334

<211>1518

<212>DNA

＜213〉streptococcus pneumoniae

<400>334

atgtttaaag?ttttacaaaa?agttggaaaa?gcttttatgt?tacctatagc?tatacttcct?60

gcagcaggtc?tacttttggg?gattggtggt?gcactttcaa?acccaaccac?gatagcaact?120

tatccaatac?tagacaatag?tatttttcaa?tcaatattcc?aagtaatgag?ctctgcagga?180

gaggttgtat?tcagtaattt?gtcactactt?ctctgtgtgg?gattatgtat?tggcttagcg?240

aaacgagata?aaggaaccgc?tgcgttagca?ggagtaactg?gttacttagt?tatgactgca?300

acgatcaaag?ctttggtaaa?actttttatg?gcagaaggat?ctgcaattga?tactggagtt?360

attggagcat?tagttgtcgg?aatagttgcc?gtatatttgc?acaaccgata?taacaatatt?420

caattacctt?ccgctttagg?attctttgga?ggttcacgct?tcgttcctat?tgttacatcg?480

ttctcttcta?tcttgattgg?ctttgtcttc?tttgttattt?ggccaccttt?ccaacaactt?540

cttgtttcta?caggtggata?tatttctcag?gcgggtccaa?ttggaacttt?tctatatgga?600

tttttaatga?gactttctgg?agcagtaggc?ttacatcata?taatttaccc?tatgttttgg?660

tatactgaac?ttggtggtgt?tgaaactgtt?gcaggacaaa?cagtggttgg?agctcaaaaa?720

atattttttg?ctcaattagc?cgatttggcc?cattctggat?tatttacaga?aggaacaagg?780

ttttttgcag?gtcgtttctc?aacaatgatg?ttcggtttac?cggctgcctg?tttagcgatg?840

taccatagtg?ttcctaaaaa?tcgtcgtaaa?aaatacgcgg?gtttgttttt?tggagttgct?900

ttaacatctt?ttattaccgg?tattacagaa?ccaattgaat?ttatgtttct?attcgtcagt?960

ccggttctat?atgttgttca?cgcattcctt?gatggtgtta?gcttctttat?tgcagacgtc?1020

ttaaatattt?caataggaaa?cacattttca?ggaggtgtaa?tcgatttcac?tttatttgga?1080

attttgcagg?ggaacgctaa?gacgaattgg?gttcttcaga?ttccatttgg?acttatttgg?1140

agtgttttgt?attatattat?ttttagatgg?ttcattactc?aattcaacgt?tctaacgcca?1200

gggcgaggag?aagaagtaga?ttctaaagaa?atttctgaat?ccgcagattc?aacttcaaat?1260

actgcagatt?atttaaaaca?ggatagccta?caaattatca?gagccttggg?tggatcaaat?1320

aatatagaag?atgtagatgc?ttgtgtgaca?cgtttacgtg?tagctgtaaa?agaagttaat?1380

caagttgata?aagcactttt?aaaacaaatt?ggtgcagttg?atgtcttaga?agtgaagggt?1440

ggcattcaag?caatctatgg?agcaaaagca?atcttatata?aaaatagtat?taatgaaatt?1500

ttaggtgtag?atgattaa 1518

<210>335

<211>1329

<212>DNA

＜213〉streptococcus pneumoniae

<400>335

atgaaattta?gaaaattagc?ttgtacagta?cttgcgggtg?ctgcggttct?tggtcttgct?60

gcttgtggca?attctggcgg?aagtaaagat?gctgccaaat?caggtggtga?cggtgccaaa?120

acagaaatca?cttggtgggc?attcccagta?tttacccaag?aaaaaactgg?tgacggtgtt?180

ggaacttatg?aaaaatcaat?catcgaagcg?tttgaaaaag?caaacccaga?tataaaagtg?240

aaattggaaa?ccatcgactt?caagtcaggt?cctgaaaaaa?tcacaacagc?catcgaagca?300

ggaacagctc?cagacgtact?ctttgatgca?ccaggacgta?tcatccaata?cggtaaaaac?360

ggtaaattgg?ctgagttgaa?tgacctcttc?acagatgaat?ttgttaaaga?tgtcaacaat?420

gaaaacatcg?tacaagcaag?taaagctgga?gacaaggctt?atatgtatcc?gattagttct?480

gccccattct?acatggcaat?gaacaagaaa?atgttagaag?atgctggagt?agcaaacctt?540

gtaaaagaag?gttggacaac?tgatgatttt?gaaaaagtat?tgaaagcact?taaagacaag?600

ggttacacac?caggttcatt?gttcagttct?ggtcaagggg?gagaccaagg?aacacgtgcc?660

tttatctcta?acctttatag?cggttctgta?acagatgaaa?aagttagcaa?atatacaact?720

gatgatccta?aattcgtcaa?aggtcttgaa?aaagcaacta?gctggattaa?agacaatttg?780

atcaataatg?gttcacaatt?tgacggtggg?gcagatatcc?aaaactttgc?caacggtcaa?840

acatcttaca?caatcctttg?ggcaccagct?caaaatggta?tccaagctaa?acttttagaa?900

gcaagtaagg?tagaagtggt?agaagtacca?ttcccatcag?acgaaggtaa?gccagctctt?960

gagtaccttg?taaacgggtt?tgcagtattc?aacaataaag?acgacaagaa?agtcgctgca?1020

tctaagaaat?tcatccagtt?tatcgcagat?gacaaggagt?ggggacctaa?agacgtagtt?1080

cgtacaggtg?ctttcccagt?ccgtacttca?tttggaaaac?tttatgaaga?caaacgcatg?1140

gaaacaatca?gcggctggac?tcaatactac?tcaccatact?acaacactat?tgatggattt?1200

gctgaaatga?gaacactttg?gttcccaatg?ttgcaatctg?tatcaaatgg?tgacgaaaaa?1260

ccagcagatg?ctttgaaagc?cttcactgaa?aaagcgaacg?aaacaatcaa?aaaagctatg?1320

aaacaatag 1329

<210>336

<211>840

<212>DNA

＜213〉streptococcus pneumoniae

<400>336

atgcaatcta?cagaaaaaaa?accattaaca?gcctttactg?ttatttcaac?aatcattttg?60

ctcttgttga?ctgtgctgtt?catctttcca?ttctactgga?ttttgacagg?ggcattcaaa?120

tcacaacctg?atacaattgt?tattcctcct?cagtggttcc?ctaaaatgcc?aaccatggaa?180

aacttccaac?aactcatggt?gcagaaccct?gccttgcaat?ggatgtggaa?ctcagtattt?240

atctcattgg?taaccatgtt?cttagtttgt?gcaacctcat?ctctagcagg?ttatgtattg?300

gctaaaaaac?gtttctatgg?tcaacgcatt?ctatttgcta?tctttatcgc?tgctatggcg?360

cttccaaaac?aagttgtcct?tgtaccattg?gtacgtatcg?tcaacttcat?gggaatccat?420

gatactctct?gggcagttat?cttgcctttg?attggatggc?cattcggtgt?cttcctcatg?480

aaacagttca?gtgaaaatat?ccctacagag?ttgcttgaat?cagctaaaat?cgacggttgt?540

ggtgagattc?gtaccttctg?gagtgtagcc?ttcccgattg?tgaaaccagg?gtttgcagcc?600

cttgcaatct?ttaccttcat?caatacttgg?aatgactact?tcatgcaatt?ggtaatgttg?660

acttcacgta?acaatttgac?catctcactt?ggggttgcga?ccatgcaggc?tgaaatggca?720

accaactatg?gtttgattat?ggcaggagct?gcccttgctg?ctgttccaat?cgtcacagtc?780

ttcctagtct?tccaaaaatc?cttcacacag?ggtattacta?tgggagcggt?caaaggataa?840

<210>337

<211>1890

<212>DNA

＜213〉streptococcus pneumoniae

<400>337

atgaaaaaaa?cttttttctt?actggtgtta?ggcttgtttt?gccttcttcc?actctctgtt?60

tttgccattg?atttcaagat?aaactcttat?caaggggatt?tgtatattca?tgcagacaat?120

acggcagagt?ttagacagaa?gatagtttac?cagtttgagg?aggactttaa?gggccaaatc?180

gtgggacttg?gacgtgctgg?taagatgcct?agcgggtttg?acattgaccc?tcatccaaag?240

attcaggccg?cgaaaaacgg?tgcagaacta?gcagatgtga?ctagcgaagt?aacagaagaa?300

gcggatggtt?atactgtgag?agtctataat?ccaggtcagg?agggcgacat?agttgaagtt?360

gacctcgtct?ggaacttaaa?aaatttactt?ttcctttatg?atgatatcgc?tgaattaaat?420

tggcaacctc?tgacagatag?ttcagagtct?attgaaaagt?ttgaatttca?tgtaagggga?480

gacaaggggg?ctgaaaaact?ctttttccat?acagggaaac?tttttagaga?gggaacgatt?540

gaaaagagta?accttgatta?tactatccgt?ttagacaatc?ttccggctaa?gcgtggagtt?600

gagttgcatg?cctattggcc?tcggaccgat?tttgctagcg?ctagggatca?gggattgaaa?660

gggaatcgtt?tagaagagtt?taataagata?gaagactcga?ttgttagaga?aaaagatcag?720

agtaaacaac?tcgttacttg?ggtcctccct?tcgatccttt?ccatctcctt?gttattgagt?780

gtctgcttct?attttattta?tagaagaaag?accactcctt?cagtcaaata?tgccaaaaat?840

catcgtctct?atgaaccacc?aatggaatta?gagcctatgg?ttttatcaga?agcagtctac?900

tcgacctcct?tggaggaagt?gagtcccttg?gtcaagggag?ctggaaaatt?cacctttgat?960

caacttattc?aagctacctt?gctagatgtg?atagaccgtg?ggaatgtctc?tatcatttca?1020

gaaggagatg?cagttggttt?gaggctagta?aaagaagatg?gtttgtcaag?ctttgagaaa?1080

gactgcctaa?atctagcttt?ttcaggtaaa?aaagaagaaa?ctctttccaa?tttgtttgcg?1140

gattacaagg?tatctgatag?tctttatcgt?agagccaaag?tttctgatga?aaaacggatt?1200

caagcaagag?ggcttcaact?caaatcttct?tttgaagagg?tattgaacca?gatgcaagaa?1260

ggagtgagaa?aacgagtttc?cttctggggg?ctcccagatt?attatcgtcc?tttaactggt?1320

ggggaaaagg?ccttgcaagt?gggtatgggt?gccttgacta?tcctgcccct?atttatcgga?1380

tttggtttgt?tcttgtacag?tttagacgtt?catggctatc?tttacctccc?tttgccaata?1440

cttggttttc?tagggttagt?tttgtctgtt?ttctattatt?ggaagcttcg?actagataat?1500

cgtgatggtg?ttctaaatga?agcgggagct?gaggtctact?atctctggac?cagttttgaa?1560

aatatgttgc?gtgagattgc?acgattggat?caggctgaac?tggaaagtat?tgtggtctgg?1620

aatcgcctct?tggtctatgc?gaccttattt?ggctatgcgg?acaaggttag?tcatttgatg?1680

aaggttcatc?agattcaagt?ggaaaatcca?gatatcaatc?tctatgtagc?ttatggctgg?1740

cacagtacgt?tttatcattc?aacagcacaa?atgagccatt?atgctagtgt?cgcaaataca?1800

gcaagcacct?actctgtatc?ttctggaagt?ggaagttctg?gtggtggctt?ctctggaggc?1860

ggaggtggcg?gcagtatcgg?tgccttttaa 1890

<210>338

<211>2661

<212>DNA

＜213〉streptococcus pneumoniae

<400>338

atgaaaaaag?taagaaagat?atttcagaag?gcagttgcag?gactgtgctg?tatatctcag?60

ttgacagctt?tttcttcgat?agttgcttta?gcagaaacgc?ctgaaaccag?tccagcgata?120

ggaaaagtag?tgattaagga?gacaggcgaa?ggaggagcgc?ttctaggaga?tgccgtcttt?180

gagttgaaaa?acaatacgga?tggcacaact?gtttcgcaaa?ggacagaggc?gcaaacagga?240

gaagcgatat?tttcaaacat?aaaacctggg?acatacacct?tgacagaagc?ccaacctcca?300

gttggttata?aaccctctac?taaacaatgg?actgttgaag?ttgagaagaa?tggtcggacg?360

actgtccaag?gtgaacaggt?agaaaatcga?gaagaggctc?tatctgacca?gtatccacaa?420

acagggactt?atccagatgt?tcaaacacct?tatcagatta?ttaaggtaga?tggttcggaa?480

aaaaacggac?agcacaaggc?gttgaatccg?aatccatatg?aacgtgtgat?tccagaaggt?540

acactttcaa?agagaattta?tcaagtgaat?aatttggatg?ataaccaata?tggaatcgaa?600

ttgacggtta?gtgggaaaac?agtgtatgaa?caaaaagata?agtctgtgcc?gctggatgtc?660

gttatcttgc?tcgataactc?aaatagtatg?agtaacattc?gaaacaagaa?tgctcgacgt?720

gcggaaagag?ctggtgaggc?gacacgttct?cttattgata?aaattacatc?tgattcagaa?780

aatagggtag?cgcttgtgac?ttatgcttcc?actatctttg?atgggaccga?gtttacagta?840

gaaaaagggg?tagcagataa?aaacggaaag?cgattgaatg?attctctttt?ttggaattat?900

gatcagacga?gttttacaac?caataccaaa?gattatagtt?atttaaagct?gactaatgat?960

aagaatgaca?ttgtagaatt?aaaaaataag?gtacctaccg?aggcagaaga?ccatgatgga?1020

aatagattga?tgtaccaatt?cggtgccact?tttactcaga?aagctttgat?gaaggcagat?1080

gagattttga?cacaacaagc?gagacaaaat?agtcaaaaag?tcattttcca?tattacggat?1140

ggtgtcccaa?ctatgtcgta?tccgattaat?tttaatcatg?ctacgtttgc?tccatcatat?1200

caaaatcaac?taaatgcatt?ttttagtaaa?tctcctaata?aagatggaat?actattaagt?1260

gattttatta?cgcaagcaac?tagtggagaa?catacaattg?tacgcggaga?tgggcaaagt?1320

taccagatgt?ttacagataa?gacagtttat?gaaaaaggtg?ctcctgcagc?tttcccagtt?1380

aaacctgaaa?aatattctga?aatgaaggcg?gctggttatg?cagttatagg?cgatccaatt?1440

aatggtggat?atatttggct?taattggaga?gagagtattc?tggcttatcc?gtttaattct?1500

aatactgcta?aaattaccaa?tcatggtgac?cctacaagat?ggtactataa?cgggaatatt?1560

gctcctgatg?ggtatgatgt?ctttacggta?ggtattggta?ttaacggaga?tcctggtacg?1620

gatgaagcaa?cggctactag?ttttatgcaa?agtatttcta?gtaaacctga?aaactatacc?1680

aatgttactg?acacgacaaa?aatattggaa?cagttgaatc?gttatttcca?caccatcgta?1740

actgaaaaga?aatcaattga?gaatggtacg?attacagatc?cgatgggtga?gttaattgat?1800

ttgcaattgg?gcacagatgg?aagatttgat?ccagcagatt?acactttaac?tgcaaacgat?1860

ggtagtcgct?tggagaatgg?acaagctgta?ggtggtccac?aaaatgatgg?tggtttgtta?1920

aaaaatgcaa?aagtgctcta?tgatacgact?gagaaaagga?ttcgtgtaac?aggtctgtac?1980

cttggaacgg?atgaaaaagt?tacgttgacc?tacaatgttc?gtttgaatga?tgagtttgta?2040

agcaataaat?tttatgatac?caatggtcga?acaaccttac?atcctaagga?agtagaacag?2100

aacacagtgc?gcgacttccc?gattcctaag?attcgtgatg?tgcggaagta?tccagaaatc?2160

acaatttcaa?aagagaaaaa?acttggtgac?attgagttta?ttaaggtcaa?taaaaatgat?2220

aaaaaaccac?tgagaggtgc?ggtctttagt?cttcaaaaac?aacatccgga?ttatccagat?2280

atttatggag?ctattgatca?aaatggcact?tatcaaaatg?tgagaacagg?tgaagatggt?2340

aagttgacct?ttaaaaatct?gtcagatggg?aaatatcgat?tatttgaaaa?ttctgaacca?2400

gctggttata?aacccgttca?aaataagcct?atcgttgcct?tccaaatagt?aaatggagaa?2460

gtcagagatg?tgacttcaat?cgttccacaa?gatataccag?cgggttacga?gtttacgaat?2520

gataagcact?atattaccaa?tgaacctatt?cctccaaaga?gagaatatcc?tcgaactggt?2580

ggtatcggaa?tgttgccatt?ctatctgata?ggttgcatga?tgatgggagg?agttctatta?2640

tacacacgga?aacatccgta?a 2661

<210>339

<211>1998

<212>DNA

＜213〉streptococcus pneumoniae

<400>339

atgaaatcaa?tcaacaaatt?tttaacaatg?cttgctgcct?tattactgac?agcgagtagc?60

ctgttttcag?ctgcaacagt?ttttgcggct?gggacgacaa?caacatctgt?taccgttcat?120

aaactattgg?caacagatgg?ggatatggat?aaaattgcaa?atgagttaga?aacaggtaac?180

tatgctggta?ataaagtggg?tgttctacct?gcaaatgcaa?aagaaattgc?cggtgttatg?240

ttcgtttgga?caaatactaa?taatgaaatt?attgatgaaa?atggccaaac?tctaggagtg?300

aatattgatc?cacaaacatt?taaactctca?ggggcaatgc?cggcaactgc?aatgaaaaaa?360

ttaacagaag?ctgaaggagc?taaatttaac?acggcaaatt?taccagctgc?taagtataaa?420

atttatgaaa?ttcacagttt?atcaacttat?gtcggtgaag?atggagcaac?cttaacaggt?480

tctaaagcag?ttccaattga?aattgaatta?ccattgaacg?atgttgtgga?tgcgcatgtg?540

tatccaaaaa?atacagaagc?aaagccaaaa?attgataaag?atttcaaagg?taaagcaaat?600

ccagatacac?cacgtgtaga?taaagataca?cctgtgaacc?accaagttgg?agatgttgta?660

gagtacgaaa?ttgttacaaa?aattccagca?cttgctaatt?atgcaacagc?aaactggagc?720

gatagaatga?ctgaaggttt?ggcattcaac?aaaggtacag?tgaaagtaac?tgttgatgat?780

gttgcacttg?aagcaggtga?ttatgctcta?acagaagtag?caactggttt?tgatttgaaa?840

ttaacagatg?ctggtttagc?taaagtgaat?gaccaaaacg?ctgaaaaaac?tgtgaaaatc?900

acttattcgg?caacattgaa?tgacaaagca?attgtagaag?taccagaatc?taatgatgta?960

acatttaact?atggtaataa?tccagatcac?gggaatactc?caaagccgaa?taagccaaat?1020

gaaaacggcg?atttgacatt?gaccaagaca?tgggttgatg?ctacaggtgc?accaattccg?1080

gctggagctg?aagcaacgtt?cgatttggtt?aatgctcaga?ctggtaaagt?tgtacaaact?1140

gtaactttga?caacagacaa?aaatacagtt?actgttaacg?gattggataa?aaatacagaa?1200

tataaattcg?ttgaacgtag?tataaaaggg?tattcagcag?attatcaaga?aatcactaca?1260

gctggagaaa?ttgctgtcaa?gaactggaaa?gacgaaaatc?caaaaccact?tgatccaaca?1320

gagccaaaag?ttgttacata?tggtaaaaag?tttgtcaaag?ttaatgataa?agataatcgt?1380

ttagctgggg?cagaatttgt?aattgcaaat?gctgataatg?ctggtcaata?tttagcacgt?1440

aaagcagata?aagtgagtca?agaagagaag?cagttggttg?ttacaacaaa?ggatgcttta?1500

gatagagcag?ttgctgctta?taacgctctt?actgcacaac?aacaaactca?gcaagaaaaa?1560

gagaaagttg?acaaagctca?agctgcttat?aatgctgctg?tgattgctgc?caacaatgca?1620

tttgaatggg?tggcagataa?ggacaatgaa?aatgttgtga?aattagtttc?tgatgcacaa?1680

ggtcgctttg?aaattacagg?ccttcttgca?ggtacatatt?acttagaaga?aacaaaacag?1740

cctgctggtt?atgcattact?aactagccgt?cagaaatttg?aagtcactgc?aacttcttat?1800

tcagcgactg?gacaaggcat?tgagtatact?gctggttcag?gtaaagatga?cgctacaaaa?1860

gtagtcaaca?aaaaaatcac?tatcccacaa?acgggtggta?ttggtacaat?tatctttgct?1920

gtagcggggg?ctgcgattat?gggtattgca?gtgtacgcat?atgttaaaaa?caacaaagat?1980

gaggatcaac?ttgcttaa 1998

<210>340

<211>1173

<212>DNA

＜213〉streptococcus pneumoniae

<400>340

atgacaatgc?agaaaatgca?gaaaatgatt?agtcgtatct?tctttgttat?ggctctgtgt?60

ttttctcttg?tatggggtgc?acatgcagtc?caagcgcaag?aagatcacac?gttggtcttg?120

caattggaga?actatcagga?ggtggttagt?caattgccat?ctcgtgatgg?tcatcggttg?180

caagtatgga?agttggatga?ttcgtattcc?tatgatgatc?gggtgcaaat?tgtaagagac?240

ttgcattcgt?gggatgagaa?taaactttct?tctttcaaaa?agacttcgtt?tgagatgacc?300

ttccttgaga?atcagattga?agtatctcat?attccaaatg?gtctttacta?tgttcgctct?360

attatccaga?cggatgcggt?ttcttatcca?gctgaatttc?tttttgaaat?gacagatcaa?420

acggtagagc?ctttggtcat?tgtagcgaaa?aaaacagata?caatgacaac?aaaggtgaag?480

ctgataaagg?tggatcaaga?ccacaatcgc?ttggagggtg?tcggctttaa?attggtatca?540

gtagcaagag?atgtttctga?aaaagaggtt?cccttgattg?gagaataccg?ttacagttct?600

tctggtcaag?tagggagaac?tctctatact?gataaaaatg?gagagatttt?tgtgacaaat?660

cttcctcttg?ggaactatcg?tttcaaggag?gtggagccac?tggcaggcta?tgctgttacg?720

acgctggata?cggatgtcca?gctggtagat?catcagctgg?tgacgattac?ggttgtcaat?780

cagaaattac?cacgtggcaa?tgttgacttt?atgaaggtgg?atggtcggac?caatacctct?840

cttcaagggg?caatgttcaa?agtcatgaaa?gaagaaagcg?gacactatac?tcctgttctt?900

caaaatggta?aggaagtagt?tgtaacatca?gggaaagatg?gtcgtttccg?agtggaaggt?960

ctagagtatg?ggacatacta?tttatgggag?ctccaagctc?caactggtta?tgttcaatta?1020

acatcgcctg?tttcctttac?aatcgggaaa?gatactcgta?aggaactggt?aacagtggtt?1080

aaaaataaca?agcgaccacg?gattgatgtg?ccagatacag?gggaagaaac?ccttgtatat?1140

cttgatgctt?gttgccattt?tgttgtttgg?tag 1173

<210>341

<211>1566

<212>DNA

＜213〉streptococcus pneumoniae

<400>341

atgagccaca?tatacttatc?tattttcaca?agtctcttgc?tgatgctagg?acttgtcaat?60

gttgctcaag?ccgatgaata?tttacgcatc?ggtatggaag?cagcatatgc?tccctttaac?120

tggacccagg?atgatgatag?caacggagct?gtcaaaatcg?atgggaccaa?tcagtatgcc?180

aacggatacg?atgttcaaat?cgccaagaaa?atcgctaagg?acttaggtaa?agaacctttg?240

gttgttaaaa?ccaagtggga?aggtctagtc?cctgccctta?cttctggtaa?gattgacatg?300

attatcgcag?gtatgagtcc?aactgcagaa?cgcaaacaag?aaattgcctt?ttcgagcagt?360

tactatacta?gcgaaccagt?tttgcttgtc?aaaaaagatt?ctgcctacgc?aagtgctaaa?420

tctttggatg?actttaacgg?tgcaaaaatc?acttctcaac?aaggggtcta?cctttataac?480

ttgattgcac?aaatcccagg?tgctaaaaaa?gaaacagcca?tgggagactt?cgctcaaatg?540

cgacaagctc?ttgaggctgg?tgtcattgat?gcttatgttt?ctgaacgtcc?agaagcactg?600

actgctgaag?ctgcgaactc?taagttcaag?atgattcaag?tagaacctgg?tttcaaaact?660

ggggaagaag?atacagctat?cgctatcggg?cttcgtaaaa?atgacaatcg?tattagccaa?720

atcaatgcca?gcattgaaac?catttcaaaa?gatgaccaag?ttgccttgat?ggatcgtatg?780

atcaaggaac?aacctgccga?agctacaaca?actgaagaga?ctagcagtag?tttctttagc?840

caagttgcta?aaattctttc?tgaaaactgg?caacaactct?tgcgtggtgc?tggtatcact?900

cttttaatct?ctatcgtcgg?aaccatcata?ggtctcatta?ttggacttgc?cattggtgtc?960

ttccgtactg?ctcctctctc?tgaaaacaaa?gtcatttacg?gcctacaaaa?actagtcggc?1020

tgggttctca?atgtctacat?tgaaattttc?cgtggtacgc?caatgattgt?tcaatcgatg?1080

gttatctact?atggaactgc?ccaagctttc?gggatcaacc?ttgaccgtac?actggctgct?1140

atcttcatcg?tttcaatcaa?taccggtgcc?tacatgactg?aaatcgtccg?tggtggtatc?1200

ctagcagttg?acaagggaca?atttgaagct?gcgactgctc?ttggtatgac?ccataaccag?1260

accatgcgta?agattgtcct?acctcaggta?gtccgtaaca?tcctacctgc?aactggtaat?1320

gaatttgtca?tcaatatcaa?agatacatct?gtattgaacg?ttatctctgt?tgtcgaactt?1380

tatttctcag?gaaataccgt?ggcaacacaa?acctatcaat?acttccagac?atttacaatc?1440

atcgccgtga?tttactttgt?cctcaccttc?accgtaacac?gtatcctacg?ctttatcgag?1500

cgcagaatgg?acatggatac?ctacactaca?ggtgctaacc?aaatgcaaac?ggaggatttg?1560

aaataa 1566

<210>342

<211>741

<212>DNA

＜213〉streptococcus pneumoniae

<400>342

atgacacaag?caatccttga?aattaaacac?ctcaaaaaat?cctatggaca?aaacgaagtg?60

ctaaaagaca?tttcactcac?tgtccacaag?ggagaggtca?tctctatcat?cggaagctct?120

ggaagcggaa?aatcgacctt?cctacgctcc?attaacctac?ttgaaacacc?aactgatgga?180

caaatccttt?atcatggaca?aaacgtcctc?gaaaaaggct?atgacctcac?gcaataccgt?240

gaaaagttgg?ggatggtttt?ccaatccttt?aacctctttg?aaaatctcaa?tgttcttgaa?300

aacacaatcg?tcgctcagac?aactgtccta?aaacgcgaac?gcacagaagc?tgaaaagatt?360

gccaaagaaa?acctggaaaa?ggtcggcatg?ggagaacgct?actggcaagc?caaaccaaaa?420

caactctcag?gtggtcaaaa?acaacgtgtg?gccatcgctc?gtgccctctc?catgaatccg?480

gacgctattc?tctttgatga?accaacatca?gctctcgatc?cagaaatggt?tggagaagtc?540

ctcaaaatca?tgcaggacct?ggctcaggaa?ggcttgacca?tgattgtcgt?aacccatgaa?600

atggaatttg?cccgtgatgt?ctctcaccgt?gttatcttta?tggataaggg?cgtgatcgct?660

gaagaaggta?aaccagaaga?cctcttcacc?aatcctaaag?aagaccgaac?aaaagagttc?720

cttcaacgct?atctcaaata?a 741

<210>343

<211>690

<212>DNA

＜213〉streptococcus pneumoniae

<400>343

atgaaaaagt?atcaacttct?attcaaaata?agtgcagtct?tctcttactt?atttttcgta?60

tttagtcttt?ctcagctgac?gcttatcgtc?caaaactatt?ggcaattttc?ttctcagata?120

ggcaatttat?tctggattca?aaatatcttg?agtttacttt?ttattggagt?catgattgtg?180

gttcttgtta?agacaggcca?tggttatctc?ttccgcattc?caagaaaaaa?atggctttgg?240

tattcgattt?tgacagtatt?agtgctagtg?ttccagatct?cttttaacgt?tcagacagct?300

aaacatgttc?agtcaactgc?ggaaggttgg?gctgtattga?ttggttatag?tgggactaac?360

tttgcagagc?taggtattta?tatagccctg?ttctttctgg?ttccactgat?ggaagaattg?420

atttatagag?gattactgca?acatgctttc?tttaagcatt?cgcgatttgg?tcttgatttg?480

cttcttcctt?ctattttatt?tgctctccct?catttttcaa?gcctgcctag?tctgttagat?540

atcttcgtct?ttgcaacagt?tggaatcatc?tttgctggtt?tgacccgcta?taccaagagc?600

atttatccat?cctatgcggt?gcatgtgatc?aataatattg?tagcgacctt?cccgtttttg?660

ctcacttttc?tacatagggt?cttggggtaa 690

<210>344

<211>1040

<212>DNA

＜213〉streptococcus pneumoniae

<400>344

atgaacaaga?aacaatggct?aggtcttggc?ctagttgcag?tggcagcagt?tggacttgct?60

gcatgtggta?accgctcttc?tcgtaacgca?gcttcatctt?ctgatgtgaa?gacaaaagca?120

gcaatcgtca?ctgatactgg?tggtgttgat?gacaaatcat?tcaaccaatc?agcttgggaa?180

ggtttgcagg?cttggggtaa?agaacacaat?ctttcaaaag?ataacggttt?cacttacttc?240

caatcaacaa?gtgaagctga?ctacgctaac?aacttgcaac?aagcggctgg?aagttacaac?300

ctaatcttcg?gtgttggttt?tgcccttaat?aatgcagtta?aagatgcagc?aaaagaacac?360

actgacttga?actatgtctt?gattgatgat?gtgattaaag?accaaaagaa?tgttgcgagc?420

gtaactttcg?ctgataatga?gtcaggttac?cttgcaggtg?tggctgcagc?aaaaacaact?480

aagacaaaac?aagttggttt?tgtaggtggt?atcgaatctg?aagttatctc?tcgttttgaa?540

gcaggattca?aggctggtgt?tgcgtcagta?gacccatcta?tcaaagtcca?agttgactac?600

gctggttcat?ttggtgatgc?ggctaaaggt?aaaacaattg?cagccgcaca?atacgcagcc?660

ggtgcagata?ttgtttacca?agtagctggt?ggtacaggtg?caggtgtctt?tgcagaggca?720

aaatctctca?acgaaagccg?tcctgaaaat?gaaaaagttt?gggttatcgg?tgttgatcgt?780

gaccaagaag?cagaaggtaa?atacacttct?aaagatggca?aagaatcaaa?ctttgttctt?840

gtatctactt?tgaaacaagt?tggtacaact?gtaaaagata?tttctaacaa?ggcagaaaga?900

ggagaattcc?ctggcggtca?agtgatcgtt?tactcattga?aggataaagg?ggttgacttg?960

gcagtaacaa?acctttcaga?agaaggtaaa?aaagctgtcg?aagatgcaaa?agctaaaatc?1020

cttgatggaa?gcgtaaaagt 1040

<210>345

<211>1059

<212>DNA

＜213〉streptococcus pneumoniae

<400>345

atgtctaaaa?aattacaaca?aatttcggtt?cccttgattt?ctgtattcct?aggaatttta?60

ctcggagcca?ttgtcatgtg?gatcttcggt?tatgatgcta?tttggggcta?cgaagaattg?120

ttctatacag?cctttggcag?tctgcgtggg?attggagaaa?tcttccgtgc?tatgggtcct?180

ctggtcttga?ttggtcttgg?ttttgccgtt?gccagtcgag?ctggtttctt?taacgtcgga?240

cttcctggtc?aggctttggc?aggttggatt?ctcagtggtt?ggtttgccct?gtcgcatcca?300

gatatgcccc?gtcccttgat?gattctagca?accatcgtga?ttgccttgat?tgctggtggg?360

attgtcggag?cgattccagg?tattcttagg?gcctatctag?ggacgtcaga?ggttattgta?420

accatcatga?tgaactacat?tgtcttgtat?gtagggaatg?cctttatcca?tgctttccct?480

aaagacttca?tgcaaagtac?agattcgacc?attcgtgttg?gggctaatgc?aacctatcag?540

acaccttggt?tggctgagtt?gactggtaac?tcacggatga?atattggtat?tttctttgcc?600

atcattgccg?ttgcagttat?ttggttcatg?ctcaagaaaa?caactcttgg?ttttgaaatc?660

cgtgcagttg?gtcttaatcc?acatgcttca?gaatatgctg?gtatttctgc?caagcggact?720

attatcctat?ctatgattat?ttcaggtgcc?ttggcaggtc?ttggtggagc?tgttgaaggt?780

ttgggaacct?tccagaacgt?ctatgttcaa?ggttcgtcat?tagctatcgg?atttaacgga?840

atggcggtta?gtttgcttgc?ggccaactca?ccaattggta?tactctttgc?agccttccta?900

tttggcgttc?tccaagttgg?ggctcctggt?atgaatgcgg?cgcaggtacc?atctgagctt?960

gtcagcattg?taacagcgtc?tattatcttc?tttgtcagtg?ttcattacct?tatcgaacgc?1020

tttgtcaaac?cgaaaaaaca?agttaaagga?ggtaagtaa 1059

<210>346

<211>831

<212>DNA

＜213〉streptococcus pneumoniae

<400>346

atgggagtga?aaaagaaact?aaagttgact?agtttgctag?gactgtctct?gttaatcatg?60

acagcctgtg?cgactaatgg?ggtaactagc?gatattacag?ccgaatcggc?tgatttttgg?120

agtaaattgg?tttacttctt?tgcggaaatc?attcgctttt?tatcgtttga?tattagtatc?180

ggagtgggga?ttattctctt?tacggtcttg?attcgtacag?tcctcttgcc?agtctttcag?240

gtgcaaatgg?tggcttctag?gaaaatgcag?gaagctcagc?cacgcattaa?ggcgcttcga?300

gaacaatatc?caggtcgaga?tatggaaagc?agaaccaaac?tagagcagga?aatgcgtaaa?360

gtatttaaag?aaatgggtgt?cagacagtca?gactctcttt?ggccgatttt?gattcagatg?420

ccggttattt?tggccctgtt?ccaagcccta?tcaagagttg?actttttaaa?gacaggtcat?480

ttcttatgga?ttaaccttgg?tagtgtggat?acaacccttg?ttcttccgat?tttagcagca?540

gtattcacct?ttttaagtac?ttggttgtcc?aacaaagctt?tgtctgagcg?aaatggcgct?600

acgactgcga?tgatgtatgg?gattccagtc?ttgattttta?tctttgcagt?ttatgcgcca?660

ggtggagtcg?ccctatactg?gacagtgtct?aatgcttatc?aagtcttgca?aacctatttc?720

ttgaataatc?cattcaagat?tatcgcagag?cgcgaggccg?tagtacaggc?acaaaaagat?780

ttggaaaata?gaaaaagaaa?agccaagaaa?aaggctcaga?aaacgaaata?a 831

<210>347

<211>795

<212>DNA

＜213〉streptococcus pneumoniae

<400>347

atggttatcg?atccatttgc?tatcaacgaa?ctagactatt?acttagtttc?acacttccac?60

agtgatcata?tcgacccata?cacagctgca?gcaattctca?ataatcctaa?gttagagcat?120

gttaagttta?tcggtcctta?ccactgtgga?cgaatctggg?aaggatgggg?tgttccaaaa?180

gaacgtatca?tcgttgttaa?accaggtgac?actatcgaat?taaaagatat?gaagattcat?240

gcagtagaat?catttgaccg?tacttgcttg?gtaactctcc?cagtgaacgg?tgctgatgag?300

acaggcggtg?aacttgctgg?cttggctgtt?acagatgaag?aaatggctca?aaaggctgtt?360

aactatatct?ttgaaacacc?aggtggaacc?atctatcatg?gtgcagattc?tcacttctca?420

aactattttg?caaaacatgg?taaagacttt?aaaattgatg?ttgctttgaa?taactatggt?480

gaaaatccgg?taggtatcca?agacaaaatg?acatctatcg?accttcttcg?tatggcagaa?540

aatctgcgta?ccaaagtcat?tatcccagtt?cactatgata?tctggtctaa?cttcatggct?600

tctactaatg?agattctaga?actttggaaa?atgcgaaaag?atcgcttgca?atacgatttc?660

catccattta?tctgggaagt?tggcggtaag?tacacttatc?ctcaagatca?acacttagta?720

gaataccatc?atccacgtgg?ttttgatgat?tgttttgaac?aagactctaa?cattcaattt?780

aaagctttgc?tataa 795

<210>348

<211>585

<212>DNA

＜213〉streptococcus pneumoniae

<400>348

atgttccttt?caggctggtt?gtctagtttt?gctaatactt?atatccatga?tttactgggg?60

gttcttttcc?cagatagtcc?atttttaaat?gcctttgaaa?gtgctattgc?ggctcctttg?120

gtagaagaac?ccttgaaatt?attgtcactt?gtttttgttt?tggctttgat?tcctgtgcga?180

aaattaaaat?ctttgttttt?acttggaatt?gcttccggtt?tgggattcca?aatgattaag?240

gatattggtt?atattcgtac?ggatttgcca?gagggctttg?actttactat?ttcgcgaatt?300

ttagagcgta?tcatctcagg?aattgcctct?cactggactt?tttcaggtct?agctgtagta?360

ggtgtttact?tgctttacag?agcctataaa?ggacagaagg?ttggcaagaa?acagggcctt?420

atttttctag?gtttagcctt?gggaactcac?ttcttgttta?actctccttt?tgtggagttg?480

gaaacagagt?tgcctttagc?gattccagtg?gttacggcta?ttgctctcta?tggtttttat?540

catgcttatt?gctttgttga?gaaacacaat?gagttgatga?cctag 585

<210>349

<211>390

<212>DNA

＜213〉streptococcus pneumoniae

<400>349

atgaaggtgg?aaccacgttg?cgacgtcctt?tcgaggatgt?cgcatttttt?tattaggata 60

ctaattatgg?agttgcaaga?attagtggag?cgcagttggg?caatccgaca?agcttatcac 120

gaactggaag?ttaagcatca?tgattccaag?tggacggtag?aagaagacct?cttggcttta?180

tctaatgata?ttggaaattt?ccaacgactg?gtgatgacaa?agcaaggacg?ctactatgat?240

gaaacaccct?acacactgga?acaaaaactt?tcagaaaata?tctggtggct?attagaactt?300

tctcaacgtt?tggatataga?cattctgacg?gaaatggaaa?acttcctctc?tgataaagaa?360

aagcaattga?acgttaggac?ttggaagtag 390

<210>350

<211>975

<212>DNA

＜213〉streptococcus pneumoniae

<400>350

atgcttgatt?ggaaacaatt?ttttctagcc?tatctgcgct?cccgtagtcg?tctttttatc?60

tatctgcttt?ctttggcatt?tcttgtctta?ctctttcagt?ttttatttgc?cagtctagga?120

atttacttcc?tctacttttt?cttcttgtgt?tgctttgtaa?ccatattatt?tttcacttgg?180

gacatattgg?tggaaacgca?ggtctatcgc?caggaacttc?tctatggaga?gagggaagcc?240

aagtctcctt?tggaaatagc?tttagcagaa?aaattagaag?cgcgtgagat?ggaactctat?300

cagcagaggt?caaaagcaga?aagaaaactg?acggatttgc?tggattacta?taccttgtgg?360

gtccatcaga?taaagacccc?cattgcagcc?agtcaactct?tagttgcaga?agtggtcgac?420

cgccaactga?agcagcagct?agaacaggaa?attttcaaaa?tcgactccta?taccaaccta?480

gttttacagt?acctgcgttt?agaaagtttc?catgatgatt?tggtcttaaa?gcaggttcaa?540

attgaggact?tggtcaagga?aataattcgt?aaatatgctc?ttttctttat?tcaaaaaggc?600

ttaaatgtca?atctacatga?ccttgataaa?gaaatcgtga?cggataaaaa?gtggctgcta?660

gtggttattg?agcaaatcat?ctcaaacagt?ctcaagtaca?ccaaggaagg?tggtctggag?720

atttatatgg?atgaccaaga?gctttgtatc?aaagatacgg?gaatcgggat?aaaaaacagt?780

gatgtcctcc?gagtatttga?acgtggcttt?tcaggataca?atggccgttt?gacccagcag?840

tcctctggac?ttggccttta?tctatctaag?aaaatttctg?aagaactggg?gcaccagatt?900

cgtatcgagt?ctgaggtcgg?aaaaggaacg?acagtgcgga?ttcagtttgc?tcaagtgaac?960

ttagtccttg?agtaa 975

<210>351

<211>588

<212>DNA

＜213〉streptococcus pneumoniae

<400>351

atggaactta?atacacacaa?tgctgaaatc?ttgctcagtg?cagctaataa?gtcccactat?60

ccgcaggatg?aactgccaga?gattgcccta?gcagggcgtt?caaatgttgg?taaatccagc?120

tttatcaaca?ctatgttgaa?ccgtaagaat?ctcgcccgta?catcaggaaa?acctggtaaa?180

acccagctcc?tgaacttttt?taacattgat?gacaagatgc?gctttgtgga?tgtgcctggt?240

tatggctatg?ctcgtgtttc?taaaaaggaa?cgtgaaaagt?gggggtgcat?gattgaggag?300

tacttaacga?ctcgggaaaa?tctccgtgcg?gttgtcagtc?tagttgacct?tcgtcatgac?360

ccgtcagcag?atgatgtgca?gatgtacgaa?tttctcaagt?attatgagat?tccagtcatc?420

attgtggcga?ccaaggcgga?caagattcct?cgtggtaaat?ggaacaagca?tgaatcagca?480

atcaaaaaga?aattaaactt?tgacccgagt?gacgatttca?tcctcttttc?atctgtcagt?540

aaggcaggga?tggatgaggc?ttgggatgca?atcttagaaa?aattgtga 588

<210>352

<211>891

<212>DNA

＜213〉streptococcus pneumoniae

<400>352

atgacaaaga?aacaacttca?cttggtgatt?gtgacaggga?tgagtggcgc?agggaaaact?60

gtagccattc?agtccttcga?ggatctaggt?tatttcacca?ttgataatat?gccgccagct?120

ctcttgccta?agtttttgca?gctggttgaa?attaaggaag?acaatcctaa?gttggccttg?180

gtagtggata?tgcgtagccg?ttctttcttt?tcagagattc?aagctgtttt?ggatgagttg?240

gaaaatcaag?atggtttgga?tttcaaaatc?ctctttttgg?atgcggctga?taaggaattg?300

gtcgctcgtt?acaaggaaac?cagacggagt?cacccactag?cagcagacgg?tcgtatttta?360

gatggaatca?agttggaacg?tgaactcttg?gcacctttga?aaaatatgag?ccaaaatgtg?420

gtggatacga?ctgaactcac?tccacgtgag?ctgcgcaaaa?cccttgcaga?gcagttttca?480

gaccaagaac?aagcccagtc?tttccgtatc?gaagtcatgt?ctttcggatt?taagtatgga?540

atcccgattg?atgcggactt?ggtctttgat?gtccgtttct?tgccaaatcc?ctattattta?600

ccagaactga?gaaaccaaac?gggtgtggat?gaacctgttt?atgattatgt?catgaaccat?660

cctgagtcag?aagactttta?tcaacattta?ttggccttga?ttgagccgat?tctgccaagt?720

taccaaaagg?aaggtaagtc?cgttttgacc?attgccatgg?gatgtacggg?tggacaacac?780

cgtagtgtgg?catttgctaa?acgcttggcg?caggacttat?ccaagaattg?gtctgttaat?840

gaagggcatc?gcgacaaaga?ccgcagaaag?gaaacggtaa?accgttcatg?a 891

<210>353

<211>978

<212>DNA

＜213〉streptococcus pneumoniae

<400>353

atgagaaaac?caaagataac?ggtgattggt?ggagggactg?gaagtcccgt?cattctaaaa?60

agtctgcggg?aaaaagatgt?ggaaatcgca?gctatcgtga?cggtggcaga?tgatggtggt?120

tcttcaggtg?aactccgaaa?aaatatgcaa?cagttgacac?cgccaggtga?tcttcgtaat?180

gtccttgtgg?ccatgtcgga?tatgcctaag?ttttatgaga?aggtctttca?gtatcggttc?240

tctgaggatg?ccggagcctt?tgctggccat?ccattgggaa?atctcatcat?tgctggcttg?300

tcagaaatgc?agggttcaac?ctataatgcc?atgcagttat?tgagcaaatt?tttccataca?360

acagggaaaa?tttatccttc?cagtgaccat?cctttgaccc?ttcatgcagt?ctttcaggat?420

gggacagaag?tggctggaga?gagtcatatt?gtagaccatc?gaggcataat?tgacaatgtc?480

tatgtgacca?atgccctaaa?cgatgatacg?cctctggcca?gccgtcgagt?agtgcagacc?540

atccttgaaa?gtgacatgat?tgtcctaggg?ccaggttccc?tctttacctc?tattttgccc?600

aatatcgtga?ttaaggaaat?tgggcgggct?cttttggaaa?ccaaggcaga?aattgcctat?660

gtctgcaata?tcatgaccca?acgtggggag?acggaacact?ttacagatag?cgaccacgtg?720

gaagtcttgc?atcgtcacct?tggtcgccct?tttatcgaca?ctgtcttggt?gaatattgaa?780

aaagtgcctc?aggaatacat?gaattccaac?cgttttgatg?aatacttagt?gcaagtggaa?840

cacgattttg?taggtctttg?taagcaagtt?tcgcgcgtga?tttcatctaa?cttccttcgt?900

ctggaaaatg?gcggtgcctt?ccacgatgga?gatttgattg?tggacgagtt?gatgcgcatt?960

atacaggtga?aaaaatga 978

<210>354

<211>1179

<212>DNA

＜213〉streptococcus pneumoniae

<400>354

atgaaaaatt?tgataaagtt?gctaataatt?agattgattg?ttaacttagc?agacagtgta?60

ttttatatag?tagcattgtg?gcacgttagc?aataattatt?cttcgagcat?gttcttagga?120

atatttattg?cagtaaatta?tctaccggat?ttgttactaa?tcttttttgg?accagttatt?180

gacagagtaa?atccgcaaaa?aattcttata?atatcaattt?tggttcaatt?agcagtggct?240

gtaatatttt?tattattatt?aaaccaaata?tcattttggg?tgataatgag?tctagtgttt?300

atttcagtaa?tggctagctc?cataagttac?gtgatagaag?atgtgttgat?tcctcaagtg?360

gtagaatatg?ataagattgt?atttgcaaat?tctcttttta?gtatttcgta?taaagtatta?420

gattctattt?ttaattcatt?cgcatcattt?ttacaggtgg?cagtaggatt?tattttattg?480

gttaagatag?atataggcat?atttttactt?gctctattta?tattgttgtt?gttaaaattt?540

agaactagca?atgcgaatat?agaaaacttc?tctttcaaat?attacaagag?agaagtgttg?600

caaggtacaa?agtttatttt?aaataataaa?ttattattta?aaaccagtat?ttctttaacg?660

cttataaact?ttttttattc?atttcagaca?gtagttgtac?cgattttttc?tattcgatat?720

tttgatggtc?cgatttttta?tggtattttt?ttaactattg?ctggtttggg?tggtatattg?780

ggaaatatgc?tagcgccaat?cgtaataaaa?tatttaaaat?cgaatcaaat?tgttggtgta?840

tttctttttt?tgaacggctc?aagttggtta?gtagcaattg?ttataaaaga?ctatacttta?900

tcacttattt?tatttttcgt?ttgttttatg?tctaaaggag?tcttcaatat?tatttttaat?960

tcgttgtacc?aacaaatacc?tccacatcaa?cttcttggta?gggtaaatac?taccattgat?1020

tctattattt?cttttggaat?gccaattggt?agtttagttg?caggaacgct?tattgatttg?1080

aatattgaat?tagtgttaat?tgctattagc?ataccttatt?ttttgttttc?ttatattttt?1140

tatacggata?atggattgaa?agaatttagt?atatattag 1179

<210>355

<211>678

<212>DNA

＜213〉streptococcus pneumoniae

<400>355

atgatgtcta?acaaaaataa?ggaaattctg?atttttgcga?ttctctatac?agtcctcttt?60

atgtttgatg?gcgttaaatt?gctggcttct?ttaatgccat?ctgccattgc?aaattatctt?120

gtttatgtag?ttttagctct?atatggctcc?ttcttgttca?aggatagatt?gatccaacaa?180

tggaaggaga?ttagaaagac?taaaagaaaa?ttcttctttg?gagtcttaac?aggatggctc?240

tttctcattc?tgatgactgt?tgtctttgaa?tttgtatcag?agatgttgaa?gcagtttgtg?300

ggactagatg?gacaaggtct?aaatcagtct?aatattcaaa?gtacctttca?agaacaacca?360

ctactgatag?ctgtttttgc?ttgtgtcatt?ggacctctgg?tagaagaatt?atttttccgt?420

caggtcttat?tgcattactt?gcaggaacgg?ttgtcaggtt?tactaagcat?tattctggta?480

ggacttgttt?ttgctctgac?tcatatgcac?agtttggctc?tatcagagtg?gattggtgca?540

gttggttact?taggtggagg?ccttgccttt?tctattattt?atgtgaaaga?aaaagagaat?600

atctactatc?ccctacttgt?tcacatgtta?agcaacagcc?tctccttaat?cattttagct?660

atcagtatag?taaaatga 678

<210>356

<211>1158

<212>DNA

＜213〉streptococcus pneumoniae

<400>356

ttgaaaaagc?caattatcga?attcaaaaac?gtctctaaag?tttttgaaga?cagcaacacc?60

aaggttctca?aagacatcaa?ctttgagttg?gaagaaggga?aattctacac?ccttctaggt?120

gcatctggtt?cggggaaatc?aactatccta?aacattattg?caggtttact?ggatgcgacg?180

acaggagata?tcatgctaga?cggtgttcgt?atcaatgata?ttccaaccaa?caagcgcgac?240

gtacataccg?tcttccaatc?ctatgccttg?ttcccacata?tgaatgtgtt?tgaaaatgtt?300

gcctttccac?ttcgcttgcg?taaaattgat?aagaaagaaa?tcgagcagcg?tgtagcggaa?360

gttctcaaga?tggttcagtt?ggaaggttat?gaaaaacgtt?ccatccgcaa?actttctgga?420

ggacaacgtc?agcgtgtggc?catcgcccgt?gctatcatca?accaaccccg?tgtggtcttg?480

ttggacgagc?ctttatcagc?gctggacttg?aaattgagaa?cagacatgca?gtacgaattg?540

cgtgaattac?aacaacgatt?gggcattacc?tttgtctttg?tcactcacga?tcaggaagaa?600

gctcttgcca?tgagtgactg?gattttcgtt?atgaatgatg?gcgagattgt?ccagtctgga?660

acccctgtgg?acatctacga?tgagccaatc?aaccactttg?ttgccacctt?tatcggggag?720

tcaaacatct?tgccaggtac?catgattgag?gactacttgg?tcgaatttaa?cggcaaacgc?780

tttgaagcgg?ttgatggtgg?gatgaagcca?aatgaacctg?ttgaggtcgt?tattcgtcca?840

gaggacttgc?gcattaccct?tcctgaagaa?ggcaagctcc?aagttaaggt?cgatacccag?900

cttttccgtg?gagttcatta?tgaaattatc?gcctatgacg?aacttggaaa?tgaatggatg?960

atccactcaa?cccgtaaggc?tatcgtgggt?gaggaaatcg?gtctggactt?tgaaccagaa?1020

gacatccaca?tcatgcgtct?caatgaaacc?gaagaagagt?tcgatgctcg?tattgaggag?1080

tacgtagaaa?tcgaagagca?agaagcaggt?ttgatcaatg?caatcgagga?ggaaagagat?1140

gaagaaaaca?agctctaa 1158

<210>357

<211>621

<212>DNA

＜213〉streptococcus pneumoniae

<400>357

atgaaatcaa?tgagaatctt?atttttgtta?gctttaattc?aaatcagttt?gagtagctgt?60

ttcctatgga?aggaatgcat?cttgtccttt?aaacaaagta?cagctttttt?catcggaagc?120

atggttttcg?tttcaggaat?ctgtgctgga?gtaaattatc?tttatacccg?taagcaagaa?180

gtccatagtg?tcctagccag?taagaagtcg?gtgaagcttt?tttacagtat?gttactctta?240

attaatttgt?taggagctgt?tcttgttttg?tcagataact?tgttcatcaa?aaatacgctg?300

cagcaagaat?tagttgactt?tttattgcca?tccttctttt?tcctatttgg?gctagatttg?360

ctgatttttt?tacccttgaa?aaaatacgtg?cgcgattttc?ttgctatgct?ggacagaaaa?420

aagacagtgt?tggtgactat?tttagcaaca?cttcttttct?taagaaatcc?aatgaccatt?480

gtctcacttc?tgatttatat?tggactgggc?ttgttttttg?cagcctatct?tgtcccaaat?540

tcggttaaga?aggaagtttc?cttttatggt?catattttcc?gagatcttgt?attggtcatt?600

gttacgctca?ttttctttta?g 621

<210>358

<211>1017

<212>DNA

＜213〉streptococcus pneumoniae

<400>358

atggttaaaa?aaattattgg?aatggtgcta?gctttacttt?ctgtaactgt?agtaggagta?60

ggtgtttttg?cttatactat?ttatcaacaa?gggacagaaa?ccttagctaa?aacctataaa?120

aaaatcggtg?aagaaaccaa?ggttattgaa?gcgactgaac?ctctaaccat?tctgttaatg?180

ggagtggaca?ccggaaatgt?tgaacgaact?gaaacttggg?tcggtagaag?tgatagcatg?240

atcttgatga?cagtgaatcc?taaaacgaaa?aaaacaacaa?tgatgagttt?agagcgggat?300

attctgacgc?gcattgaatc?agggaatggt?caggctcatg?aagcgaaact?gaactcagca?360

tatgcagatg?gtggagcaga?gcttgctata?gaaaccattc?aaaaaatgat?gaatatccat?420

attgatcgct?atgtgatggt?caatatgaga?ggattgcaaa?aactagtgga?tgcagtagga?480

ggtattacag?tcaataatat?cctaggtttc?ccaatttcta?tcagtgacca?agaagaattt?540

aatactattt?ctatcggtgt?tggggagcaa?catattgggg?gagaagaagc?cctagtctat?600

gcacgaatgc?gttaccaaga?tcctgagggg?gattatggtc?gtcaaaaacg?tcaacgtgaa?660

gttattcaaa?aagtcatgga?aaaagctctc?agtttaaata?gcattggtca?ttatcaagag?720

attctaaaag?ctttgagtga?caatatgcag?accaatattg?atttgtctgc?aaaaagtatc?780

cctaacttgc?taggctataa?agattcattt?aaaaccattg?aaactcagca?gttgcagggt?840

gaaggagaga?tacttcaagg?tgtttcttac?cagattgttt?cgagagcaca?tatgttggaa?900

atgcaaaatc?tactccgacg?ttctttggga?caagaagaag?ttactcagct?tgaaaccaat?960

gcggttttat?ttgaagattt?atttggcaga?gcacctgttg?gtgatgaaga?taattaa 1017

<210>359

<211>996

<212>DNA

＜213〉streptococcus pneumoniae

<400>359

atgaaaaaac?aagcctatgt?cattattgct?ctcacctcct?tcctatttgt?cttttttttc?60

tcccacagct?tgctggaaat?acttgatttt?gactggtcta?tctttttgca?cgatgtcgaa?120

aaaacagaaa?aatttgtctt?tttattgttg?gttttcagca?tgtccatgac?ctgtctctta?180

gccctgtttt?ggcgagggat?cgaagagctt?tctctaagaa?aaatgcaggc?taatctcaag?240

cgtttattag?cagggcaaga?agtggttcag?gttgcagatc?cagatttgga?tgccagtttc?300

aagtccttat?caggtaaact?taaccttttg?acagaggctc?ttcaaaaagc?tgaaaatcag?360

agccttgctc?aggaagagga?aatcatcgag?aaggaacgga?agcgaattgc?tcgggatttg?420

cacgatacag?tcagtcagga?gttgtttgcg?gcccacatga?ttttatcggg?tatcagtcag?480

caggctttga?aattggatag?agaaaagatg?cagacccagt?tgcagagtgt?cacagctatt?540

ttagaaacag?cccagaagga?tttgcgggtt?ttgctcttgc?atttgcgacc?agttgaactg?600

gagcagaaga?gcttgataga?agggattcaa?attcttttaa?aagagcttga?ggacaagagt?660

gatcttaggg?ttagtctcaa?gcagaatatg?acgaaattgc?ctaagaaaat?cgaggagcat?720

atcttccgta?tcctgcaaga?gttgattagc?aataccctcc?gccatgccca?ggcatcttgc?780

ctagatgtct?acctctatca?gacagatgtt?gaattgcaac?tgaaggtggt?ggacaatggg?840

attggtttcc?agttagggag?cttagacgac?ttgagttatg?gactgcgaaa?tatcaaggag?900

cgggttgaag?atatggctgg?aacagttcaa?ctcttgacag?ctcccaagca?agggctggcg?960

gttgatatcc?gtattcccct?gttagataag?gaatga 996

<210>360

<211>867

<212>DNA

＜213〉streptococcus pneumoniae

<400>360

atgattgttt?ccattatttc?tcaaggattt?gtctgggcta?ttctaggtct?gggaatcttt?60

atgacattta?ggattttaaa?ctttccagat?atgacgacag?aaggttcctt?ccctcttggg?120

ggagctgttg?ctgtcacttt?gataaccaaa?ggcgtgaacc?catttttagc?gacacttgtt?180

gctgtaggag?caggttgttt?ggctggaatg?gcagcaggcc?ttctttatac?aaaagggaag?240

atcccaacct?tgctctcagg?gattttggtg?atgacttctt?gtcactcaat?catgctcttg?300

attatgggac?gtgcgaattt?aggcctgctt?ggaaccaagc?aaattcagga?tgttttgcct?360

tttgattcgg?atttgaatca?actcttgaca?ggtctcatct?ttgtgagtat?tgttattgct?420

ctcatgctct?ttttcttgga?cactaaactc?ggacaagcct?atattgctac?aggggataat?480

cctgatatgg?ctagaagttt?cgggattcat?actggacgca?tggagctcat?gggcttggtc?540

ttatcaaatg?gtgtgattgc?ccttgcaggt?gccctcattg?ctcagcaaga?aggttatgcc?600

gatgtgtctc?gagggatcgg?ggttatcgtt?gtggggcttg?caagtttgat?tattggagaa?660

gttattttca?agagtttgag?cttggcagag?cgtttggtta?ctatcgttgt?aggttctatc?720

gcttatcaat?ttttagtgtg?ggcagttatc?gcacttggct?ttaatacaag?ttaccttcgt?780

ttatacagtg?ccttgatttt?agcagtctgc?ctcatgattc?caacatttaa?gcaaacaatc?840

ttgaaaggag?ccaagttaag?caaatga 867

<210>361

<211>1068

<212>DNA

＜213〉streptococcus pneumoniae

<400>361

atgaaaaaaa?tgaaagtttg?gtctactgta?cttgcaacgg?gagttgctct?tactacactt?60

gctgcttgct?ctggaggttc?aaattctacg?actgcttctt?catctgaaga?aaaagctgat?120

aaaagtcaag?aattagttat?ctattcgaac?tcagtctcaa?atggtcgtgg?tgattggtta?180

actgctaaag?caaaagaagc?tggttttaat?ataaaaatgg?ttgatatcgc?tggcgctcaa?240

ttagcagacc?gtgttattgc?tgagaagaat?aatgcagttg?cagatatggt?atttggaatt?300

ggtgctgttg?attcaaataa?aattagagat?caaaaattac?tagtacagta?caagcctaaa?360

tggttagata?aaattgatca?atctttatca?gataaagata?attattataa?tcctgtgatt?420

gttcaaccat?tagttttaat?tggggcgcct?gatgtaaaag?aaatgcctaa?agattggact?480

gaattaggta?gtaagtataa?aggtaaatat?tcaatttctg?gtcttcaagg?aggtacagga?540

cgggcaattc?tagcaagtat?cttagttcga?taccttgatg?ataaaggtga?attaggtgtt?600

tccgaaaaag?gttgggaagt?agcaaaagaa?tatttgaaaa?atgcatacac?tcttcaaaag?660

ggagaaagtt?caattgttaa?gatgttagac?aaagaagatc?caatacaata?tggaatgatg?720

tggggttctg?gtgcattagt?tggacaaaaa?gaacaaaatg?ttgttttcaa?agttatgact?780

cctgagattg?gtgtaccatt?tgtaactgaa?caaactatgg?ttttaagcac?tagtaaaaaa?840

caagcgttag?ctaaagaatt?tattgattgg?tttggtcaat?cagaaattca?agtagaatat?900

agtaagaact?ttggatctat?tcctgcaaat?aaagatgccc?tcaaagatct?acctgaagat?960

acgaagaaat?ttgttgatca?agtgaaacca?caaaatattg?actgggaagc?tgttggaaag?1020

catttggatg?aatgggtaga?aaaagctgaa?ttagaatacg?tacaataa 1068

<210>362

<211>1011

<212>DNA

＜213〉streptococcus pneumoniae

<400>362

atgattaaat?ttgataatat?tcaaattaaa?tatggtgatt?ttgttgcaat?tgataatctg?60

aatttagata?tacatgaagg?ggaatttttt?acatttcttg?ggccttcagg?atgtggtaaa?120

tcaactactt?tgagagcatt?ggtaggtttt?ctagatccat?catcaggaag?tattgaagtt?180

aatggaacag?atgtcactca?tttggaacct?gaaaagcgtg?gaattggtat?tgtatttcaa?240

tcttatgcgc?tatttccaac?tatgactgtt?tttgataata?ttgcatttgg?tttaaaagtt?300

aagaaggtag?ctccagatgt?tattaaagct?aaagtatcag?cagtggcagc?aaaaattaag?360

atctctgatc?aacagttaca?gcgtaatgta?tcagaattat?ctgggggtca?acaacaaagg?420

gtagcattgg?ctcgtgctct?ggttcttgaa?cctaaaattc?tttgtctaga?tgaaccattg?480

tcaaaccttg?acgcaaaatt?acgtgtagat?ttgagaaaag?agttgaaaag?acttcaaaaa?540

gagttaggta?ttactacttt?atatgttact?catgatcaag?aggaagcctt?gactttatct?600

gatagaattg?cagtctttaa?caatggatac?atcgaacagg?tcggtacacc?agtagagatt?660

tatcataatt?ctcaaactga?atttgtatgt?gattttattg?gagatattaa?tgttttgacc?720

gatgaaacag?tccacgaagt?attattgaaa?aatacaagcg?ttttcttaga?ggataaaaaa?780

ggatacattc?gattagagaa?agttcgattc?aatcgtgaaa?ctgaacaaga?ttttattcta?840

aaagggacaa?ttattgatgt?tgagttttct?ggagttacaa?ttcactatac?aataaaagtt?900

tctgaaagtc?agattcttaa?tgtaacaagt?attgatagtc?aggctgctat?tagatctgtc?960

ggagaaagtg?tggaattatt?tatcacacca?tcagacgttc?tgcaatttta?a 1011

<210>363

<211>1692

<212>DNA

＜213〉streptococcus pneumoniae

<400>363

atgcgtcata?aattaaattt?aaaagattgg?cttattcgtt?tagggttaat?ctggttctta?60

gtaacattta?ttatttatcc?aaactttgat?ctagtagtga?atgtatttgt?aaaaggagga?120

gaattttccc?ttgatgctgt?acatcgtgtt?ctaaaatctc?agagggcact?tcagagtatt?180

atgaacagtt?ttaagttagc?attttcactc?attattacag?ttaatgtcgt?aggtattctt?240

tgtgttctat?ttacagagta?ctttgatatt?aaaggtgcta?aaattttaaa?attaggttat?300

atgacctctt?taatttatgg?aggagtggtt?ttagcgactg?gatataaatt?tgtctatggt?360

ccttatggat?tgattacaaa?atttttacaa?aatgttatcc?cttctttaga?ccctaactgg?420

tttattgggt?atggtgcagt?cttattcatt?atgacatttt?caggaactgc?taatcataca?480

ttgtttttaa?caaatacaat?tcgaagcgtt?gactatcaca?ctattgaggc?tgctcgaaat?540

atgggagcaa?aaccatttac?tgttttccga?aaagtagtgt?taccaacctt?aattccaact?600

ctatttgcac?ttactattat?ggtttttctt?agtggtttat?ctgcagtagc?agcacccatg?660

attgttggtg?gtaaagaatt?tcaaactata?aatccaatga?ttattacatt?tgcagggatg?720

gggaattctc?gtgatttagc?tgccctactt?gcaattattt?taggtattgc?aactacaatt?780

ttgcttacta?tcatgaataa?gatagaaaaa?ggtggaaatt?atatttctat?ctctaagact?840

aaagcgcctc?ttaaaaaaca?aaaaattgcg?tctaagcctt?ggaatatcat?tgctcacatt?900

gtagcatatg?gattgttcac?agttttcatg?cttccactaa?tttttatagt?attatactca?960

tttacagatc?cagttgcaat?tcaaacaggt?aacttaacat?tatcaaactt?tactttagaa?1020

aattatcgct?tattctttag?taatagtgcg?gcattctctc?cattcttggt?cagctttatt?1080

tattctatta?ttgctgcgac?aacagcaaca?attctcgcag?ttgtatttgc?tcgtgttgtc?1140

agaaaacata?aatctcgttt?tgatttctta?tttgaatatg?gtgctctact?tccttggtta?1200

ctaccaagta?cacttttagc?agtaagttta?ttatttactt?ttaatcagcc?acaatttctt?1260

gtcttgaatc?agattttggt?aggtagtttg?gtaattctac?ttattgcata?tatagttgta?1320

aaaatcccat?tttcttatag?aatggtacgt?gctattttat?ttagtgttga?tgatgagatg?1380

gaagatgcag?caagaagtat?gggtgcttca?cctttttata?ctatgatgaa?ggttatcatt?1440

ccatttattt?taccggttgt?tctctctgtt?attgctttaa?actttaactc?tttattaact?1500

gacttcgact?tatctgtatt?cctttaccat?cccctagctc?aaccattagg?tattacgatt?1560

cgatctgcag?gtgatgaaac?agcaacatct?aatgcacaag?ctctggtatt?tgtttataca?1620

attgttctga?tgattatttc?tggaacggta?ttatacttca?cacaaagacc?ggggcgtaaa?1680

gtaaggaaat?aa 1692

<210>364

<211>5

<212>PRT

<213>Artificial?Sequence

<220>

<221>SITE

<222>(3)

<223>Xaa＝any?amino?acid

<220>

<223>Description?of?Artificial?Sequence：Cell?wall

anchoring?motif

<400>364

Leu?Pro?Xaa?Thr?Gly

1 5

<210>365

<211>18

<212>DNA

<213>Artificiai?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>365

gcgggatccg?ccaccatg 18

<210>366

<211>10

<212>DNA

<213>Artificial?Seauence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>366

ttgcggccgc 10

<210>367

<211>38

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>367

cggatccgcc?accatgtctt?ctaatgaatc?tgccgatg 38

<210>368

<211>39

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>368

ttgcggccgc?ctgtttagat?tggatatctg?taaagactt 39

<210>369

<211>40

<212>DNA

<213>Artificial?Seauence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>369

cgcggatccg?ccaccatgga?ttttccttca?aatttggagg 40

<210>370

<211>29

<212>DNA

<213>Artificial?Seauence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>370

ttgcggccgc?accgtactgg?ctgctgact 29

<210>371

<211>39

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>371

cggatccgcc?accatgagtg?agatcaaaat?tattaacgc 39

<210>372

<211>29

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>372

ttgcggccgc?cgttccatgg?ttgactcct 29

<210>373

<211>38

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>373

cgcggatccg?ccaccatgtg?ggacatattg?gtggaaac 38

<210>374

<211>32

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>374

ttgcggccgc?ttcacttgag?caaactgaat?cc 32

<210>375

<211>42

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>375

cgcggatccg?ccaccatgtc?acaagaaaaa?acaaaaaatg?aa 42

<210>376

<211>28

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>376

ttgcggccgc?atcgacgtag?tctccgcc 28

<210>377

<211>43

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>377

cgcggatccg?ccaccatgct?ggttggaact?ttctactatc?aat 43

<210>378

<211>29

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>378

ttgcggccgc?aactttcgtc?cctttttgg 29

<210>379

<211>34

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>379

cgcggatccg?ccaccatggg?caattctggc?ggaa 34

<210>380

<211>35

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>380

ttgcggccgc?ttgtttcata?gcttttttga?ttgtt 35

<210>381

<211>39

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>381

cgcggatccg?ccaccatgct?attgatacga?aatgcaggg 39

<210>382

<211>37

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>382

ttgcggccgc?aacataatct?agtaaataag?cgtagcc 37

<210>383

<211>34

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>383

cgcggatccg?ccaccatgac?ggcgacgaat?tttc 34

<210>384

<211>35

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>384

ttgcggccgc?ttaattcgtt?tttgaactag?ttgct 35

<210>385

<211>40

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>385

cgcggatccg?ccaccatggc?tgtttttctt?cgctatcatg 40

<210>386

<211>34

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>386

ttgcggccgc?tttcttcaac?aaaccttgtt?cttg 34

<210>387

<211>39

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>387

cgcggatccg?ccaccatggg?taaccgctct?tctcgtaac 39

<210>388

<211>31

<212>DNA

<213>Artificial?Sequence

<220>

<223>Description?of?Artificial?Sequence：Primer

<400>388

ttgcggccgc?gcttccatca?aggattttag?c 31

Claims (22)

1. streptococcus pneumoniae protein or polypeptide, it has and is selected from shown in following sequence or the table 3 each sequence in the sequence:

MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKSNPS

AQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGM

TLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNE

DKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKK

AAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVIL

TQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE。

2. streptococcus pneumoniae protein or polypeptide, it has the sequence that is selected from sequence shown in the table 2.

3. streptococcus pneumoniae protein or polypeptide, it has the sequence that is selected from sequence shown in the table 4.

4. each protein or polypeptide among the claim 1-3, it is provided with pure basically form.

With claim 1 to 4 in each defined substantially the same protein or polypeptide.

6. the homologue or the derivative of each defined protein or polypeptide in the claim 1 to 5.

7. an antigenicity and/or immunogenic fragments of showing defined protein among the 2-4 or polypeptide.

8. nucleic acid molecule, it contains following sequence or is made up of following sequence:

(i) the arbitrary dna sequence dna shown in the table 3 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) coding schedule 3 proteinic homologue, derivative or the fragments sequence of defining.

9. nucleic acid molecule, it contains following sequence or is made up of following sequence:

(i) the arbitrary dna sequence dna shown in the table 1 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) coding schedule 1 proteinic homologue, derivative or the fragments sequence of defining.

10. nucleic acid molecule, it contains following sequence or is made up of following sequence:

(i) the arbitrary dna sequence dna shown in the table 4 or its RNA equivalent;

(ii) with (i) in arbitrary sequence complementary sequence;

(iii) with (i) or the sequence encoding same protein (ii) or the sequence of polypeptide;

(iv) with (i), (ii) and the substantially the same sequence of arbitrary sequence (iii);

(v) coding schedule 4 proteinic homologue, derivative or the fragments sequence of defining.

11. have the protein or the polypeptide that are selected from the sequence of sequence shown in the table 2-4, or its homologue, derivative and/or fragment are as immunogen and/or antigenic purposes.

12. containing one or more, an immunogenicity and/or antigenic composition, said composition have protein or polypeptide or its homologue or the derivative of sequence that is selected from sequence shown in the table 2-4, and/or any the fragment in them.

13. described immunogenicity of claim 10 and/or antigenic composition, said composition is a vaccine, perhaps can be used for diagnostic test.

14. the described vaccine of claim 13, it contains one or more other components that is selected from vehicle, thinner, adjuvant etc.

15. a vaccine composition, it contains one or more as defined nucleotide sequence in the table 1,3 or 4.

16. comprising, the method for a detection/diagnosis streptococcus pneumoniae, described method make given the test agent and at least a step that contacts as defined protein or polypeptide or its homologue, derivative or fragment among the table 2-4.

17. an antibody, described antibody capable with as table 2-4 in defined protein or polypeptide or its homologue, derivative or fragment combine.

18. the defined antibody of claim 17, described antibody is monoclonal antibody.

19. comprising, the method for a detection/diagnosis streptococcus pneumoniae, described method make given the test agent and at least a step that contacts as claim 17 or 18 defined antibody.

20. comprising, the method for a detection/diagnosis streptococcus pneumoniae, described method make given the test agent and at least a step that contacts as each defined nucleotide sequence among the claim 8-10.

Whether still 21. whether a mensuration is the method for the antimicrobial target of potential as defined protein or polypeptide among the table 2-4, described method comprises described protein of deactivation or polypeptide, and measure streptococcus pneumoniae survival in external or body.

22. can antagonism, inhibition or otherwise disturb as table 2-4 in the medicament of the function of defined protein or polypeptide or expression be used to prepare the purposes of medicine, described medicine can be used for treatment or prevention streptococcus pneumoniae infection.

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