Background technology
Mosquitoes bite sucks blood the people is itched, and can infect pathogen to the people, and in general, male mosquito can not sting the people, only has female mosquitoes just can sting the people.Studies show that, the distinctive smell that mosquito is mainly distributed by object and in the remote target of finding, this smell is exactly the smell of perspiring, find with research by the constituent analysis to sweat, mosquito relies on distinguishes that organic acid in the sweat becomes to assign to determine the position of target, because there is organic acid acceptor albumen in the olfactory organ of mosquito.In these organic acids, comprise lactic acid, lactic acid can cause that mosquito is excited, but the short chain organic acid of high concentration such as acetic acid, propionic acid, butyric acid etc. can suppress the excitement of mosquito, mosquito produce to be sought suck the inertia of target and do not think that missing stings the people, the short chain organic acid of low concentration can stimulate the excitability of mosquito, if filling the air the short chain organic acid of low concentration in this living environment, then can constantly stimulate the mosquito excitability, make mosquito produce the sensation that whole space all is the people, covered the human sweat and sent lactic acid Odor stimulation mosquito excitability, thereby reached the olfactory function of upsetting mosquito and make mosquito can not find target.
Studies show that in early days the carbonic acid gas that mosquito can also rely on object to breathe to send seeks target, however the back studies show that this is a kind of misunderstanding, mosquito can not rely on carbonic acid gas to determine target.Studies show that at present the other smell that female mosquitoes can rely on the people to breathe to distribute (non-carbonic acid gas, the taste of food of half digestion in the stomach) is sought and bitten target.In addition, mosquito can also rely on the temperature and humidity of human body to seek target.
The active ingredient of tradition mosquito-repellent incense is agricultural chemicals, mostly be carbamates and pyrethrins insecticide, belong to acetylcholinesterase (AChE) inhibitor and sodium channel adjuster, act on the nervous system of animal, belong to neurotoxin, the mode of action is mosquito is poisoned or kills and to make mosquito can not sting the people, and health is had certain harm, along with using for a long time and accumulating, it is very large to people's side effect.Mosquito is as a chain in the ecologic food chain, excessively kill ecotope is had certain adverse effect, in addition, a large amount of long-term use the along with pyrethrin pesticide because mosquito has larger fertility, produces resistance to pyrethrin pesticide easily, as seen, kill mosquitoes is not long-term useful mode, and disturbs mosquito not sting not kill mosquitoes of people, is the measure that meets bionomic control most.
Although, also have in the market by comprising product such as the Metadelphene of human body stink with perspiration information, Metadelphene is volatile, comprise human sweat and breath, 1 octene by blocking-up mosquito olfactory receptor-3-alcohol onset, insect is lost the mankind or animal are sent the sense organ of special odor, but do not have influence on mosquito to the sense of smell ability of human body respiration.Nearest scientific research shows that Metadelphene is as a culicifuge, the onset by mosquito is not felt well, but Metadelphene can only reduce the probability of mosquito bite, and produce an effect is not fine, in addition, itself also has certain toxicity, and is not fool proof to human body.
Summary of the invention
For the above-mentioned problems in the prior art, the object of the invention is to design the technical scheme that a kind of female mosquito olfaction disrupter composition and its production and use is provided, its preparation method is simple, in the production process without the three wastes, production cost is low, to personal safety, it is effective to prevent that mosquitoes bite.
Described a kind of female mosquito olfaction disrupter composition, it is characterized in that containing the organic acid of gross weight 0.1-9.9% as active princlple, contain the water of gross weight 88-99.6% as solvent, this organic acid is one or more mixtures in acetic acid, propionic acid, n-butyric acie, isobutyric acid, positive valeric acid, n-caproic acid, positive enanthic acid, Pfansteihl, the malic acid.
Described a kind of female mosquito olfaction disrupter composition is characterized in that organic acid content is 1.0-8.0%, preferred 2.0-6.0%.
Described a kind of female mosquito olfaction disrupter composition is characterized in that described solvent is distilled water, and content is 90-98%, preferred 93-96%.
Described a kind of female mosquito olfaction disrupter composition is characterized in that described organic acid is food-grade raw materials.
Described a kind of female mosquito olfaction disrupter composition is characterized in that also containing the sodium chloride of gross weight 0.1-0.5% or citric acid as preservative.
Described a kind of female mosquito olfaction disrupter composition is characterized in that also containing the water-soluble fruit-vegetable type spices of gross weight 0.1-0.5% as flavor enhancement.
The preparation method of described a kind of female mosquito olfaction disrupter composition is characterized in that: add entry, organic acid according to the above ratio in the heating agitator, the temperature of formulated product is 15-35 ℃, and being stirred to fully, dissolving namely gets product.
The preparation method of described a kind of female mosquito olfaction disrupter composition, it is characterized in that: add successively preservative and flavor enhancement after adding distilled water, organic acid stirring and dissolving according to the above ratio in the heating agitator, being stirred to fully, dissolving namely gets final products again.
The preparation method of described a kind of female mosquito olfaction disrupter composition is characterized in that: the temperature of formulated product is 20-30 ℃, preferred 20-25 ℃.
Described a kind of female mosquito olfaction disrupter composition is characterized in that said composition relieving itching and eliminating swelling product and application in preparation air sterilizing, air cleaner product behind preparation prevention mosquito bite product, mosquito bite.
Above-mentioned female mosquito olfaction disrupter composition, the form of generally volatilizing by naturally volatilization, blowing volatilization or electrical heating is evaporating into gas; Can also be by traditional electric mosquito repellent heating means, constantly regulate airborne humidity, around heater, form the temperature province identical with human body temperature, further disturb the receptor of mosquito by two factors of temperature and humidity, thereby make mosquito can't find object.
Above-mentioned a kind of female mosquito olfaction disrupter composition and its production and use, said composition simulation human body skin smell and breath odor avoid the people by mosquito bite by disturbing mosquito sense of smell, and that mosquitoes bite is effective in prevention; Raw material is all according to the food-grade standard, and the composition that makes especially is adapted to resistance weak special population such as baby, pregnant woman, children and the elderly to human-body safety; Mosquito is not had the property of killing, do not have resistance problem, do not have ecological risk yet.And the preparation method is simple, and production cost is low, without the three wastes, is conducive to environmental protection in the production process.The relieving itching and eliminating swelling product reaches for the preparation of air sterilizing, air cleaner product after also can be used for preparation prevention mosquito bite product and mosquito bite, and is of many uses.
The part that relates in the present patent application file, percentage, unless otherwise indicated, other is unit of weight.Used equipment and raw material all can be buied from market or the industry is commonly used.
Embodiment
Below in conjunction with specific embodiment and corresponding test, the invention will be further described.
Embodiment 1: drop into 90.0kg distilled water in 100L enamel stirred tank, slowly drop into again the food grade acetic acid of 9.9kg (purity is greater than 99.9%), after 20 ℃ of lower stirring and dissolving, slowly drop into again the 0.1kg citric acid, after the stirring and dissolving, final products.
Embodiment 2: drop into 99.6kg distilled water in 100L enamel stirred tank, slowly drop into again 0.1kg purity and be 99.8% food grade propionic acid, after 15 ℃ of lower stirring and dissolving, slowly drop into again 0.2kg sodium chloride, after the stirring and dissolving, slowly drop into again the water-soluble apple fragrance type spices of 0.1kg, after the stirring and dissolving final products.
Embodiment 3: drop into 98.5kg distilled water in 100L enamel stirred tank, slowly drop into again 0.5kg food grade acetic acid and 0.5kg food grade malic acid, after 25 ℃ of lower stirring and dissolving, slowly drop into again 0.3kg sodium chloride, after the stirring and dissolving, slowly drop into again the water-soluble lemon flavor spices of 0.2kg, after the stirring and dissolving final products.
Embodiment 4: drop into 91.3kg distilled water in 100L enamel stirred tank, slowly drop into 6.0kg food grade propionic acid, 0.5kg food grade acetic acid, 0.5kg food grade n-butyric acie again; 0.5kg food grade isobutyric acid, the positive valeric acid of 0.5kg food grade after 25 ℃ of lower stirring and dissolving, slowly drop into 0.4kg sodium chloride again, after the stirring and dissolving, slowly drop into the water-soluble lemon flavor spices of 0.3kg again, after the stirring and dissolving final products.
Embodiment 5: drop into 97.1kg distilled water in 100L enamel stirred tank, slowly drop into again 0.9kg n-butyric acie, 0.9kg isobutyric acid, 0.1kg n-caproic acid, the positive enanthic acid of 0.1kg, after 30 ℃ of lower stirring and dissolving, slowly drop into again 0.5kg sodium chloride, after the stirring and dissolving, slowly drop into again the water-soluble orange fragrant perfume of 0.4kg, after the stirring and dissolving final products.
Embodiment 6: drop into 93kg distilled water in 100L enamel stirred tank, slowly drop into again the positive valeric acid of 2kg, 2kg n-caproic acid, the positive enanthic acid of 2kg, after 35 ℃ of lower stirring and dissolving, slowly drop into again the 0.5kg citric acid, after the stirring and dissolving, slowly drop into again the water-soluble watermelon fragrant perfume of 0.5kg, after the stirring and dissolving final products.
Embodiment 7: drop into the 95kg running water in 100L enamel stirred tank, slowly drop into again 3kg acetic acid, 0.2kg propionic acid, 0.2kg n-butyric acie, 0.2kg isobutyric acid, the positive valeric acid of 0.2kg, 0.2kg n-caproic acid, the positive enanthic acid of 0.2kg, 0.2kg Pfansteihl, 0.6kg malic acid, after 25 ℃ of lower stirring and dissolving, final products.
The present invention is female mosquito olfaction disrupter, and the people is had good safety, in order further to reduce this medicament to the adverse effect of health, can reduce the adding of the artificial synthesis of chemicals such as spices in preparation process as far as possible.In addition, consider that the present composition is liquid, use procedure is evaporating into gas, in order to reduce the rear product solid residue amount of volatilization, solid constituent is to the obstruction of the water absorption channel of liquid component in the minimizing volatilization process, and preservative sodium chloride does not add zero, perhaps only adds seldom consumption.
The beneficial effect of above-mentioned female mosquito olfaction disrupter composition below is described by test.
Test 1: test method detects mosquito density with reference to the GB13917.8-1992 field condition, adopts the people to lure method investigation mosquito density.Arrange 2 fixing investigators (decide people, fixed point, regularly) in each experiment room, the experimenter has drawn 2 trouser legs to knee and has exposed skin, with flashlight lighting, 45min catches the mosquito that stops dropping on the exposed leg with electric mosquito-suction device continuously, identifies subsequently and record quantity, sex and the kind of mosquito.Mosquito density rate of descent (%)=1-experiment room mosquito density/blank room mosquito density.Result of the test sees Table 1.
Mosquito density and mosquito density rate of descent behind the product that table 1 use embodiment 1-7 makes
As seen from Table 1, mosquito density obviously declines to a great extent behind the product that use embodiment 1-7 makes, the mosquito density rate of descent all reaches more than 80%, wherein embodiment 1 and embodiment 7 are up to more than 90%, embodiment 2-6 mosquito density rate of descent is all above 80%, reach the effect of traditional mosquito-repellent incense, embodiment 1 and embodiment 7 are then significantly better than the effect of traditional mosquito-repellent incense.
Test 2: test method is with reference to GB13917.8-1992; the Culex quinquefasciatus of use laboratory and field-collected strains tests and on-the-spot people lures biting test; with reference to GB13917.4-92, the field-collected strains Culex quinquefasciatus worm of employing collection in worksite 2-3d after laboratory rearing is sprouted wings measures with on-the-spot people and lures method observation bite by mosquitos number and embodiment 1-7 to make the protection effect of product.Mosquito density rate of descent (%)=1-experiment room mosquito density/blank room mosquito density.
The on-the-spot prevention of the product that table 2 embodiment 1-7 makes bite by mosquitos result
From table 2 result as seen; the bite by mosquitos number of times significantly reduces behind the product that use embodiment 1-7 makes; the protection effect all reaches more than 80%; wherein embodiment 1 and embodiment 7 protection effects reach more than 90%; especially the protection effect of embodiment 1 reaches 100%; the successful of embodiment 1 and embodiment 7 is better than traditional mosquito-repellent incense, and the protection effect of embodiment 2-6 also slightly is better than traditional mosquito-repellent incense.
Test 3: subjects is 20 people, on average everyone is by mosquito bite 5 times, totally 100 person-times, behind mosquito bite, affected part 5cm diameter range is smeared in the product spraying of using immediately embodiment 1-7 to make, and the beginning timing, add up respectively 1 minute, detumescence after antipruritic person-time and 1,5,10 and 30 minute in 3 minutes person-time, computational methods: overworked person-time of antipruritic percentage=end/total statistics person-time * 100; Detumescence percentage=detumescence person-time/always add up person-time * 100.
Relieving itching and eliminating swelling (spraying is smeared) behind the product mosquito bite that table 3 embodiment 1-7 makes
Process |
1 minute antipruritic percentage % |
3 minutes antipruritic percentage % |
1 minute detumescence percentage % |
5 minutes detumescence percentage % |
10 minutes detumescence percentage % |
30 minutes detumescence percentage |
Embodiment 1 |
82 |
93 |
52 |
63 |
71 |
85 |
Embodiment 2 |
76 |
87 |
45 |
60 |
65 |
74 |
Embodiment 3 |
74 |
84 |
43 |
55 |
68 |
76 |
Embodiment 4 |
70 |
80 |
41 |
61 |
69 |
75 |
Embodiment 5 |
65 |
76 |
38 |
55 |
62 |
69 |
Embodiment 6 |
64 |
77 |
41 |
55 |
60 |
71 |
Embodiment 6 |
66 |
77 |
43 |
59 |
64 |
76 |
Embodiment 7 |
78 |
90 |
48 |
61 |
69 |
81 |
From table 3 result as seen, the product spraying of using embodiment 1-7 to make smears that antipruritic effect reaches 64-82% after 1 minute, and antipruritic effect reached 77-93% in 3 minutes, the best results of embodiment 1 and embodiment 7.Effect to detumescence, 1 minute detumescence effect 41-52% is smeared in spraying, 5 minutes detumescence effect 55-63%, 10 minutes detumescence effect 60-71%, 30 minutes detumescence effect 71-85%, the product that visible embodiment 1-7 makes has obvious detumescence effect, along with continuing of service time, the detumescence effect improves constantly, wherein the detumescence best results of embodiment 1 and embodiment 7.
Test 4: the product control virus that embodiment 1-7 makes and the effect of germ see Table 4.
The product control virus that table 4 embodiment 1-7 makes and the effect table of germ
From table 4 result as seen, use the virus such as product infected by influenza, coronavirus, infectious bronchitis virus and Avian pneumo-encephalitis virus that embodiment 1-7 makes and the pathogens such as streptococcus, typhoid fever bacterium, dysentery bacillus and tulase to have certain killing action, effect to germ is better than viral effect, the wherein best results of embodiment 1 and embodiment 7.