CN101406431A - External-use formulation for preventing bite of mosquito - Google Patents
External-use formulation for preventing bite of mosquito Download PDFInfo
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- CN101406431A CN101406431A CNA2008102272151A CN200810227215A CN101406431A CN 101406431 A CN101406431 A CN 101406431A CN A2008102272151 A CNA2008102272151 A CN A2008102272151A CN 200810227215 A CN200810227215 A CN 200810227215A CN 101406431 A CN101406431 A CN 101406431A
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Abstract
The invention discloses an external preparation for avoiding stings of mosquitoes. The preparation contains acid, and the pH value of the preparation is between 4 and 6. The external preparation has variety of preparation formulations. The experimental results prove that the effects for avoiding the mosquitoes can last for more than 15 hours. The external preparation does not contain any pesticide, and is safe and has no toxicity for a human body for long-time use.
Description
Technical field:
The present invention relates to a kind of external preparation of preventing bite of mosquito, be specifically related to the preparation for external application to skin of pH value in 4～6 scopes.
Background technology:
Being used to spread upon the mosquito-repellent that prevents mosquito bite on the human body at present all contains insecticide both at home and abroad, is " diethyltoluamide " as the main effective ingredient of human body anophelifuge commonly used.
" diethyltoluamide " chemical name: N, the N-n,N-diethyl meta-toluamide, the external vehicle economy ET of diethyltoluamide is a kind of widely used insecticide.It is sprayed on skin or the clothes, avoids the worm mosquito bite.The general use amount of diethyltoluamide is that 5-30% does not wait, effective mosquito-proof time 4-7 hour.
Although there are some researches show, the diethyltoluamide repelling effect is certain, and it does not feel well mosquito, has confirmed that the mosquito of the neuronic antennal sensilla of A type olfactory receptor has significant reaction to diethyltoluamide.But insecticide belongs to the pesticide management area, and is dangerous to human body.
Summary of the invention:
The purpose of this invention is to provide and a kind ofly do not contain insecticide, and prevent that mosquito bite is effective, the preparation for external application to skin safely and effectively of long action time.
Preparation for external application to skin of the present invention is the various external preparation that contain acid, and the pH value of preparation is in 4～6 scopes.
Described acid, comprise all mineral acids of preparation acceptable or organic acid, as in phosphoric acid, hydrochloric acid, lactic acid, malic acid, gluconic acid, adipic acid, oxalic acid, acetic acid, salicylic acid, citric acid, succinic acid, fumaric acid, ascorbic acid or the ascorbic acid one or more.Preferred organic acid is as acetic acid.
Contain multiple organic substances such as lactic acid, amino acids, amine in the perspiration that human body skin is discharged.Wherein, the aminoacids complex that the reaction of lactic acid and amino acids is generated can with the aminated compounds effect, generate trimethylamine (trimethylamine; TMA).Find that according to scientific research in recent years the main cause that human body is subjected to mosquito bite is because the synthetic trimethylamine of human body self has a kind of special abnormal smells from the patient, can attract mosquito consumingly.Therefore,, or reduce or eliminate trimethylamine, can play the effect of avoiding attracting mosquito, thereby prevent mosquito biting the people if can prevent the formation of human body surface trimethylamine.
The acid that is contained in the preparation of the present invention has two effects: 1, can react with amine substance, thereby stop amine substance and compounded amino acid reaction to generate trimethylamine; 2, for the trimethylamine that has generated on the human body skin, these acidic materials can react with it, play the effect that reduces or eliminates trimethylamine.
Preparation of the present invention can have multiple dosage form, as emulsifiable paste, emulsion, solution, ointment, spray etc., according to Various Seasonal, selects for use under the different situations.As can be made into forms such as cream, floral water, gel.
Except that active component acid and pharmaceutical base, also can contain conventional various adjuvant, the additive that uses of external agent in the preparation, as wetting agent, spice, coloring agent, antiseptic, emulsifying agent, surfactant, viscosifier, aerosol etc.
Also can add other effective ingredient as required to skin beneficiating, as vitamins, sun-proof class medicine etc.
The above addible other composition, those skilled in the art can select for use as required.As long as to the human body no side effects, and preparation can accept, and all can use.
The preparation method of preparation of the present invention is by the conventional preparation method preparation of general medicine external preparation or skin cosmetic.As acid being joined in the previously prepared pharmaceutical base, also acid can be carried out simultaneously the preparation of preparation as raw material and various other preparation raw material.No matter which kind of method should be controlled the finished product pH value in 4～6 scopes.
The using method of the mosquito-proof preparation of the present invention is preparation to be smeared or is sprayed on the human body skin or on the clothes, can play tangible mosquito repellent effect.
Consumption of this preparation and number of times can be according to using needs, and as mosquito density, go out the time, body surface exposed area etc. are grasped flexibly.Can one day with once or for several times.
As safe as a house because of this preparation, do not contain any insecticide and skin irritation material, life-time service is to the human body safety non-toxic.Repeatedly use repeatedly or continuously and also can not cause any harm human body.
Another aspect of the present invention is found this purposes of external preparation that can prepare preventing bite of mosquito with sour first.
What provide among the embodiment is the preparation of the ointment and the solution of several different formulations, and has provided and wherein fill a prescription 1 and the human body of diethyltoluamide preparation checking contrast experiment.The result shows: compares with the diethyltoluamide preparation, and acidic formulation anophelifuge better effects if of the present invention, mosquito-proof effective time is long.
For further specifying the present invention, the following examples are for example understood several prescriptions, but scope of the present invention is not limited to these prescriptions, and scope of the present invention is as the criterion with claim.
The specific embodiment:
Preparation pH described in following examples measures, and all carries out with acidometer.
Embodiment 1 prescription 1 acetic acid emulsifiable paste
Acetic acid 20g, hard ester acid 140g, glyceryl monostearate 50g
White vaseline 50g, liquid paraffin 20g, hexadecanol 20g, sorbester p18 5g,
Polysorbate60 60g, glycerol 100g, distilled water adds to 1000g
Preparation method: get white vaseline, hexadecanol, hard ester acid, glyceryl monostearate, liquid paraffin, span melts in water-bath, be heated to 80 ℃ oil phase; Other gets tween, glycerol, adding distil water, heating in water bath to 80 ℃ water.Water slowly is added in the oil phase, and the limit edged stirs, until condensation.In condensation process, add acetic acid, promptly get the emulsifiable paste that contains acetic acid.Measuring pH is 5.4.
Embodiment 2 prescriptions 2 lactic acid emulsifiable pastes
Lactic acid 50g, octadecanol 200g, vaseline 250g, Tween 80 30g,
Glycerol 100g, carbamide 45g, ethyl hydroxybenzoate 1g, distilled water adds to 1000g
Preparation method: get vaseline, ethyl hydroxybenzoate, octadecanol and in water-bath, melt, be heated to 75 ℃ oil phase; Other gets Tween 80, glycerol, carbamide, adding distil water, heating in water bath to 80 ℃ water.Water slowly is added in the oil phase, and the limit edged stirs, until condensation.In condensation process, add lactic acid, promptly get the emulsifiable paste that contains lactic acid.Measuring pH is 6.0.
Embodiment 3 prescriptions 3 salicylic acid emulsifiable pastes
Salicylic acid 3g, stearic acid 12.5g, glyceryl monostearate 17g, Cera Flava 5g,
Ceresine 70g, liquid Paraffin 420ml, white vaseline 70g, double stearic acid aluminium 10g, calcium hydroxide 1g,
Ethyl hydroxybenzoate 1g, carbamide 50g, distilled water adds to 1000g
Preparation method: get stearic acid, glyceryl monostearate, Cera Flava, ceresine heat fused in water-bath, add liquid Paraffin, white vaseline, double stearic acid aluminium again, be heated to 85 ℃.In addition calcium hydroxide, ethyl hydroxybenzoate, carbamide are dissolved in the distilled water, are heated to 85 ℃, add gradually in the oil phase, the limit edged stirs.Under agitation add salicylic acid, condensation promptly gets emulsifiable paste.Measuring pH is 4.1.
Embodiment 4 prescriptions 4 acetums
Acetic acid 20g, propylene glycol 50g, Mentholum 10g, ethanol 700g, distilled water adds to 1000g
Preparation method: under the room temperature above-mentioned raw materials is mixed, promptly obtain the acetic acid water preparation.Measuring pH is 5.1.
Embodiment 5 prescriptions 5 lactic acid solutions
Lactic acid 50g, propylene glycol 50g, Mentholum 10g, ethanol 700g, distilled water adds to 1000g
Preparation method: under the room temperature above-mentioned raw materials is mixed, promptly obtain water preparation.Measuring pH is 5.8.
Embodiment 6 prescriptions 6 salicylic acid solutions
Salicylic acid 2g, propylene glycol 50g, Mentholum 10g, ethanol 700g, distilled water adds to 1000g
Preparation method: under the room temperature above-mentioned raw materials is mixed, promptly obtain water preparation.Measuring pH is 4.2.
The comparison of test example 1 acidic formulation and diethyltoluamide preparation preventing bite of mosquito effect
1 subjects and environment
Select the student of Beijing Normal University 50 examples, wherein male 23 examples, women 27 examples, age 19-22 year.
Personnel's selected condition: the person of participating in the experiment more easily attracts mosquito bite at ordinary times, and bites the back skin sensitivity.
Experimental enviroment: room for individual study and dormitory that mosquito is often arranged.
2 test preparations
1) trial target: acetic acid preparation: by the emulsifiable paste that contains acetic acid of embodiment 1 formulation.
2) reference substance: diethyltoluamide preparation: in the previous embodiment 1; Do not add acetic acid and in oil phase, add the emulsifiable paste that diethyltoluamide 100g prepares.
3 test methods
Testing crew is divided into 2 groups at random, every group 25 example.
Each group is used a kind of preparation, and two kinds of preparation usings method are identical, promptly bathes the back emulsifiable paste and is coated with whole body outward, once a day, uses continuously 30 days.The requirement person of participating in the experiment:
1) duration of test is filled in mosquito-proof effect recording every day, promptly be recorded in use preparation after several hours first by mosquito bite.Wherein, less than counted one hour in 30 minutes, surpassed 30 minutes and counted next hour;
2) duration of test is stopped using other mosquito-proof measure.
4 test effects statistics
See Table 1, data are after two groups of experimenters use acetic acid preparation of the present invention or diethyltoluamide preparation respectively in the table, this time first by the number of mosquito bite.
Table 1 acetic acid preparation and the mosquito-proof effect comparison of diethyltoluamide preparation
5 conclusion (of pressure testing)s
The mosquito-proof effect of acetic acid preparation group reached more than 15 hours, used 24 hours, still had 1/3 experimenter to keep mosquito-proof effect, obviously was better than diethyltoluamide preparation group.
Claims (10)
1, a kind of external preparation of preventing bite of mosquito is characterized in that containing acid, and the pH value of preparation is 4～6.
2, the described external preparation of claim 1, described acid is preparation acceptable mineral acid or organic acid.
3, the described external preparation of claim 1, described acid is selected from one or more in phosphoric acid, hydrochloric acid, lactic acid, malic acid, gluconic acid, adipic acid, oxalic acid, acetic acid, salicylic acid, citric acid, succinic acid, fumaric acid or the ascorbic acid.
4, the described external preparation of claim 1, described acid is organic acid.
5, the described external preparation of claim 4, described acid is acetic acid.
6, arbitrary described external preparation in the claim 1～5 is emulsifiable paste, emulsion, solution, ointment, spray or gel.
7, the described external preparation of claim 6 is emulsifiable paste or solution.
8, the purposes that is equipped with the external preparation of preventing bite of mosquito with processed with acid.
9, the described purposes of claim 8, described acid is organic acid.
10, the described purposes of claim 9, described acid is acetic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102272151A CN101406431B (en) | 2008-11-25 | 2008-11-25 | External-use formulation for preventing bite of mosquito |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102272151A CN101406431B (en) | 2008-11-25 | 2008-11-25 | External-use formulation for preventing bite of mosquito |
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| Publication Number | Publication Date |
|---|---|
| CN101406431A true CN101406431A (en) | 2009-04-15 |
| CN101406431B CN101406431B (en) | 2011-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008102272151A Expired - Fee Related CN101406431B (en) | 2008-11-25 | 2008-11-25 | External-use formulation for preventing bite of mosquito |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614092A (en) * | 2012-04-26 | 2012-08-01 | 福建省金鹿日化股份有限公司 | Mosquito driving ointment and preparation method thereof |
| CN102824359A (en) * | 2011-06-17 | 2012-12-19 | 张廷兴 | Mosquito-toxin-removing liniment |
| CN101564032B (en) * | 2009-05-21 | 2013-04-03 | 浙江林学院 | Female mosquito olfaction disrupter composition, preparation method and applications thereof |
| CN103444787A (en) * | 2013-08-23 | 2013-12-18 | 湖南亨通生物技术有限公司 | Extraction method of cedar oil and cedar oil anophelifuge prepared from cedar oil |
| CN104224614A (en) * | 2014-08-15 | 2014-12-24 | 南通功成精细化工有限公司 | Mosquito-repelling sunscreen gel and preparation method thereof |
| CN108684728A (en) * | 2018-07-27 | 2018-10-23 | 郑州兰茜生物工程有限公司 | A kind of safety edible type culicifuge and preparation method thereof |
-
2008
- 2008-11-25 CN CN2008102272151A patent/CN101406431B/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564032B (en) * | 2009-05-21 | 2013-04-03 | 浙江林学院 | Female mosquito olfaction disrupter composition, preparation method and applications thereof |
| CN102824359A (en) * | 2011-06-17 | 2012-12-19 | 张廷兴 | Mosquito-toxin-removing liniment |
| CN102614092A (en) * | 2012-04-26 | 2012-08-01 | 福建省金鹿日化股份有限公司 | Mosquito driving ointment and preparation method thereof |
| CN103444787A (en) * | 2013-08-23 | 2013-12-18 | 湖南亨通生物技术有限公司 | Extraction method of cedar oil and cedar oil anophelifuge prepared from cedar oil |
| CN103444787B (en) * | 2013-08-23 | 2016-03-30 | 湖南亨通生物技术有限公司 | A kind of cedar oil extracting method and cedar oil culicifuge thereof |
| CN104224614A (en) * | 2014-08-15 | 2014-12-24 | 南通功成精细化工有限公司 | Mosquito-repelling sunscreen gel and preparation method thereof |
| CN108684728A (en) * | 2018-07-27 | 2018-10-23 | 郑州兰茜生物工程有限公司 | A kind of safety edible type culicifuge and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101406431B (en) | 2011-11-02 |
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Granted publication date: 20111102 Termination date: 20211125 |