CN101559226A - Drug component for preventing and curing pig diarrhea - Google Patents
Drug component for preventing and curing pig diarrhea Download PDFInfo
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- CN101559226A CN101559226A CNA2008100527423A CN200810052742A CN101559226A CN 101559226 A CN101559226 A CN 101559226A CN A2008100527423 A CNA2008100527423 A CN A2008100527423A CN 200810052742 A CN200810052742 A CN 200810052742A CN 101559226 A CN101559226 A CN 101559226A
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Abstract
The invention discloses a drug composite for preventing and curing pig diarrhea. Based on the parts by weight, the drug composite is prepared by the following components: 10-70 of astragalus polysaccharide and 5-60 of pig immunoglobulin. The drug composite can be used for preventing and curing the pig diarrhea, in particular viral diseases such as rotavirus diarrhea, and the like, and is also used for carrying out the symptomatic treatment to bacterial infection. Drug products prepared by the drug component have the advantages of stable product performance and low cost.
Description
Technical field
The invention belongs to field of medicaments, specifically relate to a kind of pharmaceutical composition of preventing and treating diarrhea of pigs.
Background technology
In large scale of pig farm was produced, because of all multifactor influences, piglets diarrheal sickness rate was up to 40%, and case fatality rate reaches 5%～10%, had caused very big economic loss for the production of raising pigs.Piglets diarrhoea is often caused by bacterial infection (as Escherichia coli, Salmonella), viral infection (as parvovirus, swine fever virus etc.), parasitic infection (as toxoplasma etc.), also has non-infectious reason and causes.In causing the various causes of disease of diarrhea of pigs disease, the harm of viral diarrhea is the most serious, and it can cause the death of piglet, becomes losing flesh of pig, and the reduction of the price of deed increases the harm such as spending of labour cost and expenses for medicine, is the important infectious disease of harm pig industry.
Transmissible gastroenteritis of swine, porcine epizootic diarrhea, porcine rotavirus are the main pathogen of China's viral diarrhea, other viruses also can cause the diarrhoea of pig as enterovirus infection, porcine adenovirus infection, parvovirus, Pseudorabies virus, swine fever virus simultaneously, we can say, the cause of disease of viral diarrhea is very complicated, prevent and treat viral diarrhea also the difficulty.Transmissible gastroenteritis of swine is a kind of height contact infectious intestinal disease of pig, morbidity is anxious, propagate fast, the pig at various ages only can infect, to cause that 7～10 ages in days are vomitted, seriously suffered from diarrhoea with interior piglet and high mortality (common 100%) is a feature, though and age in week, bigger or adult pig did not only almost have death, lost flesh, reduces the price of deed, the economic loss that increase medicine and manpower etc. are caused is very serious.
Porcine epizootic diarrhea (PED) is a kind of infectious disease of acute, height contact, is feature with the high mortality of watery diarrhea, vomiting, dehydration and newborn piglet.
The acute intestinal disorders of the multiple young animal that porcine rotavirus (RV) infection system is caused by rotavirus infection.Mainly occur in the piglet of age of sucking pig.Sick pig begins to occur anorexia, and dysentery appears in hyponoia then, and the black dull or yellow-white of excrement color is more stench, continues 2～4 days.Vomiting appears in indivedual pigs.Sick pig becomes thin, dehydration.Do not excite infection if having, mortality rate can not surpass 10%.
In recent years popular in rising trend of infectious diarrheal disease, also great changes have taken place for regularty of epidemic, former winter-spring season pilosity, and also had in recent years summer popular situation occur, should cause enough attention, especially on the pig farm of intensification.Complicated various understanding to diarrhoeal diseases is not enough, show as the diarrhoea that reason whatsoever causes, all be summed up as one or two kind of cause of disease, diarrhoea takes place only to be thought to be caused by one or both cause of diseases, and practical situation to be not single factors cause morbidity, often have the mixed infection of multiple cause of disease, this brings misleading with regard to the diagnosis and treatment of giving diarrhoeal diseases, affected best treatment time adversely, can not shoot the arrow at the target to the anti-system of eqpidemic disease simultaneously.The phenomenon of mixed infection is more serious, and the mixed infection rate rises year by year, only can not control diarrheal well at one or two kind of eqpidemic disease and take place in prevention and treatment, should be according to the practical situation on pig farm, formulate comprehensively epidemic prevention plan, just can receive good effect of control.Strict says, above-mentioned several diseases all do not have good treatment way, especially viral diarrhea.The environmental enhancement health, in time remove feces, strengthen the sterilization of age of sucking to sow breast, obstetric table and delivery room and child care house ground, reduce the cause of disease density in the environment, reducing and infect chance. immunoprophylaxis and environment disinfected are laid equal stress on, Drug therapy is auxilliary, can control the generation of viral diarrhea to greatest extent.
Treatment piglets diarrheal drug main will adopt antibiotic at present, but because primary disease cause of disease complexity, and the bacterial drug resistance bacterial strain constantly occur cause curative effect of medication imprecise, simultaneously, antibiotic can cause the Gaster Sus domestica alteration of intestinal flora, disturbs it to digest and assimilate function normally.Therefore be necessary to seek the new method of preventing and treating.
Porcine blood serum contains the pig immune globulin of high concentration, comprises lgG, lgA, lgE, lgM, lgD.Wherein LgG occupies an leading position in immunologic process, has various active such as antiviral, anti-extracellular toxin; The invasion that lgA avoids antibacterial and virus at mucosa organs such as protection intestinal, respiratory tract, urogenital tract, mammary gland, face plays a crucial role, and and the lgG multiple virion that neutralizes together, the immunocompetence that strengthens pig is had important function.IgM can obtain secretory piece, is not destroyed by digestive enzyme, can orally use.The pig immune globulin that extracts from Sanguis sus domestica has broad spectrum activity, can resist the invasion and attack of multiple pathogen.Pig is many with containing pig immune globulin IgG in the pig immune globulin, and IgM is few.It is safe, good effect.
China delivers about 300,000,000 of live pig every year for sale, and the Sanguis sus domestica resource is very abundant.At present, the Sanguis sus domestica major part of most meat processing combines has all emitted.The discharging of Sanguis sus domestica is serious waste, causes environmental pollution again.Sanguis sus domestica contains the rich functions composition, and wherein the porcine blood plasma pig immune globulin has the diseases prevention of the body of raising, resistance against diseases, has been applied in the products such as baby formula milk powder, ablactation infant rice flour, health food, biological medicine intermediate, oral hygiene.From pig blood, extract pig immune globulin and make artificial colostrum and feed, mortality rate of lamb and the mortality rate of piglet are descended, can effectively prevent and treat young baby's various infectious diseases and can promote the growth promoter of young stock to newborn lamb and newborn piglet.
The Radix Astragali is a kind of qi-invigorating herb, has preferably pharmacological action widely.The recent studies proof Radix Astragali has following effect: 1, enhancing body's immunological function, and can increase energy, resisting fatigue, mutation, protect the liver, suppress the effect of osteoclast, for the person that easily do not catch a cold take two weeks of the Radix Astragali or the bimester after, before the function ratio of peripheral white blood cells inducement interferon is taken medicine for high; 2, can strengthen cardiac contractile force, the heart of depletion is had cardiotonic; 3, obvious blood sugar lowering; 4, can make the expansion of coronary vasodilator and renal blood vessels, and make the expansion of whole body peripheral vessel, the skin blood circulation is freely contained, and makes hyperpietic's blood pressure drops, the diuresis of imitating in having; 5, various pathogens there is inhibitory action; 6, enhancing antibody is synthetic, has Detoxication.The sweating due to debility disease that the Radix Astragali also can be used for treating old Alzheimer's disease and causes because of hypoimmunity.The effective active composition that contains in the Radix Astragali extract is the folic acid of astragalus polysaccharides, flavone, choline, betanin, aminoacid, sucrose, glucuronic acid and trace.The immunocompetence of astragalus polysaccharides wherein is stronger.More to the pharmacotoxicological effect research of astragalus polysaccharides in recent years.It can strengthen the activation of human lymphocyte, Turnover of Mouse Peritoneal Macrophages and neutrophilic granulocyte, improves immunologic function.Astragalus polysaccharides can significantly strengthen the mouse macrophage function, can increase T percentage of cells in the thymus.Astragalus polysaccharides has antivirus action, can induce body to produce interferon, regulates body's immunity, and enhancing antibody forms, and enhancing body is to the phagocytosis of pathogenic microorganism.It is an antiviral agents, and by direct kill virus, enhancing human body immunity power produces therapeutical effect with the control secondary infection.Experimentation shows that astragalus polysaccharides has immunoregulation effect, comprises the regulating action of pair cell immunity, humoral immunization and nonspecific immunity.
Pig immune globulin and astragalus polysaccharides compositions are applied to prevention and the treatment diarrhea of pigs yet there are no report but about using.
Summary of the invention
The present invention seeks to overcome deficiency of the prior art, a kind of pharmaceutical composition of preventing and treating diarrhea of pigs is provided.
Technical scheme of the present invention is summarized as follows:
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs is made up of following component: 10-70 part astragalus polysaccharides, 5-60 part pig immune globulin by weight.
Preferably described astragalus polysaccharides is 65 parts, and described pig immune globulin is 35 parts.
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs of the present invention can be used for prevention and viral diseases such as treatment diarrhea of pigs, especially porcine rotavirus diarrhoea, and the symptomatic treatment of bacterial infection.With the formulation products stable performance that medicine of the present invention is made, with low cost.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs is made up of 65 parts of astragalus polysaccharidess and 35 parts of pig immune globulins by weight.
Embodiment 2
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs is made up of 50 parts of astragalus polysaccharidess and 50 parts of pig immune globulins by weight.
Embodiment 3
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs is made up of 45 parts of astragalus polysaccharidess and 55 parts of pig immune globulins by weight.
Embodiment 4
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs is made up of 60 parts of astragalus polysaccharidess and 40 parts of pig immune globulins by weight.
Embodiment 5
A kind of pharmaceutical composition of preventing and treating diarrhea of pigs is made up of 70 parts of astragalus polysaccharidess and 30 parts of pig immune globulins by weight.
Embodiment 6
A kind of experimental study that prevents and treats the pharmaceutical composition control piglet diarrhea of diarrhea of pigs
1 materials and methods
1.1 being 3: 2 ratio and water by weight, a kind of pharmaceutical composition of preventing and treating diarrhea of pigs of embodiment 1 preparation is mixed and made into solution.
Pig immune globulin can be bought, the self-control pig immune globulin that present embodiment adopts:
The preparation of pig immune globulin: the blood of collecting healthy slaughter pig, use sad-ammonium sulfate precipitation method in conjunction with the small amount of anion exchange agent, purification the IgG in the normal pig serum, make pig immune globulin, and the IgG that extracts is carried out purity with the method for polyacrylamide gel electrophoresis identify, can obtain single band.The protein concentration of measuring the pig immune globulin preparation with the Folim-2 phenol method is 4.84mg/ml.40% astragalus polysaccharides: Shaanxi Sen Fu Bioisystech Co., Ltd.
1.2 experimental animal and grouping
All support the feeding and management of test pig or the cement flooring is flat supports in the childbirth drylot feeding of the same terms with its sow for the examination piglet, and routine disinfection is 1 time weekly.
According to clinical observation, select the piglet with obvious symptom of diarrhea of pig farm, suburbs, Tianjin 10～50 ages in days, wherein the piglet of 10～28 ages in days has totally 50,47 of the piglets of 30～50 ages in days.
The piglet that is diagnosed as the diarrheal availability test is divided into 4 groups:
Test I group: 18 of 10～28 ages in days, 16 of 30～50 ages in days;
Test II group: 18 of 10～28 ages in days, 17 of 30～50 ages in days;
Test III group: 14 of 10～28 ages in days, 14 of 30～50 ages in days;
1.3 method
Test I group: press 10ml/ the oral pig immune globulin of body weight, every day 2 times, 3 days is a course of treatment.
Test II group: press 10ml/ body weight oral administration astragalus polysaccharide, every day 2 times, 3 days is a course of treatment.
Test III group: on the treatment basis of test I group, simultaneously by the treatment of test II group;
Curative effect judging standard:
During the treatment, examine the elasticity of the mental status, appetite, stool situation, perianal humidity and the anal sphincter of respectively organizing the disease pig every day sooner or later for twice.After the drug withdrawal 3 days every group choose 1 immediately and cut open and kill, observe the intestinal pathological changes, it is fixing to get intestinal tissue (jejunal segment), tissue slice to be done.
Cure: treatment 24～48h feces is strip, and color, abnormal smells from the patient are normal, and piglet spirit, sucking or material feeding are normal, the symptom complete obiteration.
Take a turn for the better: treatment 48～72h feces character takes a turn for the better, moisture obviously reduces clinical symptom remission or basic the disappearance.
Invalid: behind the treatment 72h, feces number of times and character do not have improvement, even the state of an illness increases the weight of.
Cure the number revolution of becoming reconciled and add up to total significant figure.Invalid number comprises death toll
2 result of the tests
2.1 observation of curative effect
From table 1, table 2 as can be seen, best results during combination treatment of the present invention; During treatment 30～50 age in days piglet diarrhea, used present composition treatment to organize its curative effect, particularly be significantly higher than astragalus polysaccharides apparently higher than other treatment group.
Table 1 10～28 ages in days diarrhoea piglet result relatively
The total piglet number of group is cured the number good revolution invalid number total significant figure total effective rate of death toll (%)
Test I organizes 18 4861 12 66.7
Test II organizes 18 44 10 78 44.4
Test III organizes 14 7610 13 92.9
Table 2 30～50 ages in days diarrhoea piglet result relatively
The total piglet number of group is cured the number good revolution invalid number total significant figure total effective rate of death toll (%)
Test I organizes 16 27719 56.3
Test II organizes 17 16 10 97 41.2
Test III organizes 14 6530 11 78.5
Studies show that the constitutional factor of diarrhea of weaned piglets is not that bacterial infection causes, but owing to stress cause intestinal injury that enzyme level and absorbability are descended, food is discharged with the diarrhoea form.And the total effective rate of its use of combination treatment group of the present invention reaches 92.9%, and with pig immune globulin total effective rate (66.7) height, both have significant difference than independent.The cumulated volume result of the test shows that compositions of the present invention all has certain effect to different days group diarrhea of pigs treatment of diseases, but with the less piglet diarrhea prevention effect the best of age in days, total effective rate reaches 92.9%.
Compositions of the present invention and pharmaceutically acceptable carrier are made injectable powder or aqueous injection, and it can be used as injection also can make oral formulations.
Claims (2)
1. a pharmaceutical composition of preventing and treating diarrhea of pigs is characterized in that being made up of following component by weight: 10-70 part astragalus polysaccharides, 5-60 part pig immune globulin.
2. a kind of pharmaceutical composition of preventing and treating diarrhea of pigs according to claim 1 is characterized in that described astragalus polysaccharides is 65 parts, and described pig immune globulin is 35 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100527423A CN101559226A (en) | 2008-04-15 | 2008-04-15 | Drug component for preventing and curing pig diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100527423A CN101559226A (en) | 2008-04-15 | 2008-04-15 | Drug component for preventing and curing pig diarrhea |
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| Publication Number | Publication Date |
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| CN101559226A true CN101559226A (en) | 2009-10-21 |
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| CNA2008100527423A Pending CN101559226A (en) | 2008-04-15 | 2008-04-15 | Drug component for preventing and curing pig diarrhea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853459A (en) * | 2016-03-29 | 2016-08-17 | 东北农业大学 | Medicinal composition used for sows to prevent and treat diarrhea of newborn piglets, and compound traditional Chinese veterinary medicinal preparation method thereof |
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2008
- 2008-04-15 CN CNA2008100527423A patent/CN101559226A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853459A (en) * | 2016-03-29 | 2016-08-17 | 东北农业大学 | Medicinal composition used for sows to prevent and treat diarrhea of newborn piglets, and compound traditional Chinese veterinary medicinal preparation method thereof |
| CN105853459B (en) * | 2016-03-29 | 2018-10-16 | 东北农业大学 | A kind of pharmaceutical composition and its compound traditional Chinese veterinary medicine preparation for sow prevention newborn piglet diarrhea |
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Open date: 20091021 |