CN101559045B - Arachidonic acid nutrition microcapsule with high temperature resistance and preparation method thereof - Google Patents
Arachidonic acid nutrition microcapsule with high temperature resistance and preparation method thereof Download PDFInfo
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- CN101559045B CN101559045B CN2009100277831A CN200910027783A CN101559045B CN 101559045 B CN101559045 B CN 101559045B CN 2009100277831 A CN2009100277831 A CN 2009100277831A CN 200910027783 A CN200910027783 A CN 200910027783A CN 101559045 B CN101559045 B CN 101559045B
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Abstract
The invention discloses an arachidonic acid nutrition microcapsule with high temperature resistance. Arachidonic acid is taken as a core material and is wrapped in the microcapsule. The wall of the microcapsule is two-layered, wherein, the inner layer is a mixture of a capsule wall material I and an antioxidant, the outer layer is a capsule wall material II. The weight percentages of the ingredients are as follows: the arachidonic acid: 10-30%, the capsule wall material I: 40-60%, the antioxidant: 1-2% and the capsule wall material II: 10-30%. The capsule wall material I is a mixture of any one or two of maltodextrin, cyclodextrine and hydroxyl propyl cellulose in arbitrary proportion, while the capsule wall material II is a mixture of any one or two of starch anhydride of octenyl succinic, alginate, corn dextrin, gelatin and acacia in arbitrary proportion. The invention also discloses a preparation method of the arachidonic acid nutrition microcapsule with high temperature resistance.The invention greatly improves heat resistance and oxidation stability of the arachidonic acid nutrition microcapsule, thus extending the shelf life of products.
Description
Technical field
The present invention relates to a kind of preparation and preparation method thereof, especially relate to a kind of arachidonic acid nutrition microcapsule with high temperature resistance and preparation method thereof.
Background technology
Arachidonic acid (Arachidonic Acid is called for short AA, promptly 5,8,11,14-eicosatetraenoic acid) belongs to the serial long-chain polyunsaturated fatty acid of ω-6.AA is a kind of important essential fatty acid, is many 20 carbon derivatives such as prostaglandin E
2(PGE
2), prostacyclin (PGI
2), thromboxane A
2(TXA
2), leukotriene Leukotirene B
4(LTB
4) and C4 (LT C
4) direct precursor, metabolism, hemorheology, blood vessel elasticity, leukocyte function and the platelet activation etc. of these biological active matter confrontation lipoproteins have important regulatory role.But AA can not de novo synthesis in human body, and must synthesize by the prolongation and the desaturation of essential fatty acids linoleic.Most AA must provide by diet, especially in fast-growing period of health.Therefore, be in quick epacmastic crowd at healths such as infant, teenager and need diet AA.But because the chemical structural formula docosatetratenoic acid of AA, 4 unsaturated bonds are promptly arranged in the carbochain of 20 carbon, oxidation, polymerization, decomposition take place in environment double center chain (unsaturated bond) gradually that be higher than 30 ℃ in temperature, thereby cause the unstable or loss of AA character, the AA microcapsule of Xiao Shouing does not also possess high temperature resistant function in the market, essential freezing preservation, thereby limited their range of application greatly.
Martek Biosciences Corp. discloses arachidonic production and using method in the patent CN1175976 of its application, its arachidonic acid be by Mortierella class strain through liquid fermentation, oils and fats through extraction, reclaim the back and directly be used as additive in the infant formula food.Can not withstand high temperatures but the AA oils and fats is exposed in the air, also very easily oxidation simultaneously, thereby be difficult under its active condition of effective maintenance and be added directly in the infant formula food.
Hubei Fuxing Biological Technology Co., Ltd. discloses a kind of micrometre level arachidonic acid emulsion and preparation method thereof in its patent CN101258929A, be applied to comparatively easily in the relevant industries such as beverage, but because its final finished is an emulsion, only limit to add in the liquid and go, so its range of application is not very wide, has limited the application of AA as nutrition enhancer to a certain extent.
Summary of the invention
Technical problem to be solved by this invention provides a kind of arachidonic acid nutrition microcapsule with high temperature resistance, and this capsule also can keep stable character under hot conditions, in the mechanical pressure environment.
The technical problem that the present invention also will solve provides the preparation method of above-mentioned arachidonic acid nutrition microcapsule with high temperature resistance.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A kind of arachidonic acid nutrition microcapsule with high temperature resistance, it is a core with the arachidonic acid, and is coated in the microcapsule; The cyst wall of described microcapsule is two-layer, internal layer is the mixture of capsule material I and antioxidant, skin is capsule material II, the percentage by weight of each component is as follows: arachidonic acid 10～30%, capsule material I 40～60%, antioxidant 1～2%, capsule material II 10～30%, described capsule material I is a maltodextrin, the mixture of any one in cyclodextrin and the hydroxypropyl cellulose or two or more arbitrary proportions, described capsule material II is an octenyl succinate starch, alginate, corn dextrin, the mixture of any one in gelatin and the arabic gum or two or more arbitrary proportions.
Wherein, described antioxidant is the mixture of any one or two or more arbitrary proportions in vitamin C, tea polyphenols and the vitamin E.
The preparation method of above-mentioned arachidonic acid nutrition microcapsule with high temperature resistance comprises the steps:
(1) capsule material I and antioxidant are dissolved in the hot water, are cooled to 30～35 ℃ after stirring is dissolved, the consumption of hot water is capsule material I and total amount of antioxidants 1～4 times;
(2) in the mixture that step (1) obtains, add arachidonic acid, carry out the embedding first time, be stirred to mix homogeneously;
(3) mixture that step (2) is obtained is through twice high pressure homogenize emulsifying, emulsifying 5～10 minutes under 15～20Mpa for the first time, emulsifying 25～30 minutes under 25～30Mpa condition for the second time;
(4) in the emulsion that step (3) obtains, add capsule material II, carry out the embedding second time, be stirred to mix homogeneously;
(5) through the arachidonic acid emulsion after twice embedding,, be prepared into microcapsule through mist projection granulating;
(6) microcapsule that step (5) is obtained makes arachidonic acid nutrition microcapsule with high temperature resistance through the hot blast airpillow-dry.
In the step (1), described hot water temperature is 60～70 ℃.
In the step (2), mixing time is 20～30 minutes.
In the step (4), mixing time is 15～25 minutes.
In the step (5), mist projection granulating adopts centrifugal spray dryer, and reaction condition is: inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is 2～30,000 commentaries on classics.
In the step (6), hot blast airpillow-dry temperature is 50～90 ℃.
Beneficial effect: arachidonic acid nutrition microcapsule with high temperature resistance of the present invention can be widely used in fields such as medicine, food, beverage, feedstuff as additive.Because this invention adopts arachidonic acid to be dispersed in the capsule material aqueous solution, finish embedding process for the first time,, utilize natural macromolecular material to carry out the secondary embedding through high pressure homogenize emulsifying, means by the different capsule materials of twice embedding in front and back combine have extraordinary heat-resisting, emulsifiability.Therefore its product heat resistance of arachidonic acid nutrition microcapsule with high temperature resistance that makes with this method has remarkable enhancing, and the product shelf life prolongs greatly, adopts hot blast airpillow-dry technology simultaneously, has obviously improved the yield of microcapsule and has reduced raw-material waste.
The specific embodiment
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand that the described concrete material proportion of embodiment, process conditions and result thereof only are used to illustrate the present invention, and should also can not limit the present invention described in detail in claims.
The employed instrument and equipment of following examples is as follows:
High pressure homogenize mulser: (GYB500-6S) East China, Shanghai high pressure homogenizer factory;
Centrifugal spray dryer: (QZ-5) Linzhou City, Xishan, Jiangsu drying machine factory;
High speed shear blender: (JJ2): Changzhou state China electrical equipment company.
Embodiment 1:
The percentage by weight of material is as follows:
Arachidonic acid 15%,
Capsule material I: maltodextrin 60%,
Antioxidant: vitamin C 2%,
Capsule material II: octenyl succinate starch 23%.
Preparation method is as follows:
(1) capsule material I and antioxidant are dissolved in 60 ℃ of hot water, are cooled to 30 ℃ after stirring is dissolved, the consumption of hot water is capsule material I and total amount of antioxidants 2 times;
(2) in the mixture that step (1) obtains, add arachidonic acid, carry out the embedding first time, stir 20min to mix homogeneously;
(3) mixture that step (2) is obtained is through the secondary high-pressure emulsifying, emulsifying 8 minutes under 15Mpa for the first time, emulsifying 25 minutes under the 25Mpa condition for the second time;
(4) in the emulsion that step (3) obtains, add capsule material II, carry out the embedding second time, stir 20min to mix homogeneously;
(5) through the arachidonic acid emulsion after twice embedding, through the centrifugal spray dryer mist projection granulating, inlet temperature is 150 ℃, and leaving air temp is 70 ℃, and the shower nozzle rotating speed is 20,000 commentaries on classics, is prepared into microcapsule;
(6) microcapsule that step (5) is obtained makes arachidonic acid nutrition microcapsule with high temperature resistance through 60 ℃ of hot blast airpillow-dry.
Embodiment 2:
The percentage by weight of material is as follows:
Arachidonic acid 30%,
Capsule material I: hydroxypropyl cellulose 40%,
Antioxidant: vitamin E 1%,
Capsule material II: arabic gum 29%.
Preparation method is as follows:
(1) capsule material I and antioxidant are dissolved in 70 ℃ of hot water, are cooled to 35 ℃ after stirring is dissolved, the consumption of hot water is capsule material I and total amount of antioxidants 3 times;
(2) in the mixture that step (1) obtains, add arachidonic acid, carry out the embedding first time, stir 30min to mix homogeneously;
(3) mixture that step (2) is obtained is through the secondary high-pressure emulsifying, emulsifying 5 minutes under 15Mpa for the first time, emulsifying 25 minutes under the 30Mpa condition for the second time;
(4) in the emulsion that step (3) obtains, add capsule material II, carry out the embedding second time, stir 15min to mix homogeneously;
(5) through the arachidonic acid emulsion after twice embedding, through the centrifugal spray dryer mist projection granulating, inlet temperature is 190 ℃, and leaving air temp is 80 ℃, and the shower nozzle rotating speed is 30,000 commentaries on classics, is prepared into microcapsule;
(6) microcapsule that step (5) is obtained makes arachidonic acid nutrition microcapsule with high temperature resistance through 90 ℃ of hot blast airpillow-dry.
Embodiment 3:
The percentage by weight of material is as follows:
Arachidonic acid 30%,
Capsule material I: cyclodextrin 30%, hydroxypropyl cellulose 25%,
Antioxidant: tea polyphenols 1%, vitamin E, 1%,
Capsule material II: gelatin 10%, corn dextrin 3%.
Preparation method is as follows:
(1) capsule material I and antioxidant are dissolved in 60 ℃ of hot water, are cooled to 35 ℃ after stirring is dissolved, the consumption of hot water is capsule material I and total amount of antioxidants 4 times;
(2) in the mixture that step (1) obtains, add arachidonic acid, carry out the embedding first time, stir 30min to mix homogeneously;
(3) mixture that step (2) is obtained is through the secondary high-pressure emulsifying, emulsifying 10 minutes under 20Mpa for the first time, emulsifying 25 minutes under the 25Mpa condition for the second time;
(4) in the emulsion that step (3) obtains, add capsule material II, carry out the embedding second time, stir 15min to mix homogeneously;
(5) through the arachidonic acid emulsion after twice embedding, through the centrifugal spray dryer mist projection granulating, inlet temperature is 160 ℃, and leaving air temp is 75 ℃, and the shower nozzle rotating speed is 30,000 commentaries on classics, is prepared into microcapsule;
(6) microcapsule that step (5) is obtained makes arachidonic acid nutrition microcapsule with high temperature resistance through 50 ℃ of hot blast airpillow-dry.
Embodiment 4
Under the condition of relative humidity 75%, place 25,35,45 ℃ of environment to preserve respectively arachidonic acid oil, commercially available common peanut tetraenoic acid microcapsule and embodiment 2 products, surveyed in every month once, detected its peroxide value, AA content quality index in continuous 5 months respectively.Experimental result (table 1～3) shows the rising of embodiment 2 products along with temperature, and its quality index rate of change all is significantly less than AA oils and fats and commercially available AA microcapsule, has tangible heat resistance, has prolonged the shelf life of its product greatly.
Stability test under 25 ℃ of conditions of table 1
Stability test under 35 ℃ of conditions of table 2
Stability test under 45 ℃ of conditions of table 3
Claims (2)
1. an arachidonic acid nutrition microcapsule with high temperature resistance is characterized in that it is a core with the arachidonic acid, and is coated in the microcapsule; The cyst wall of described microcapsule is two-layer, and internal layer is the mixture of capsule material I and antioxidant, and skin is capsule material II, and the percentage by weight of each component is as follows:
Arachidonic acid 30%,
Capsule material I: hydroxypropyl cellulose 40%,
Antioxidant: vitamin E 1%,
Capsule material II: arabic gum 29%.
2. the preparation method of the described arachidonic acid nutrition microcapsule with high temperature resistance of claim 1 is characterized in that this method comprises the steps:
(1) capsule material I and antioxidant are dissolved in 70 ℃ of hot water, are cooled to 35 ℃ after stirring is dissolved, the consumption of hot water is capsule material I and total amount of antioxidants 3 times;
(2) in the mixture that step (1) obtains, add arachidonic acid, carry out the embedding first time, stir 30min to mix homogeneously;
(3) mixture that step (2) is obtained is through the secondary high-pressure emulsifying, emulsifying 5 minutes under 15Mpa for the first time, emulsifying 25 minutes under the 30Mpa condition for the second time;
(4) in the emulsion that step (3) obtains, add capsule material II, carry out the embedding second time, stir 15min to mix homogeneously;
(5) through the arachidonic acid emulsion after twice embedding, through the centrifugal spray dryer mist projection granulating, inlet temperature is 190 ℃, and leaving air temp is 80 ℃, and the shower nozzle rotating speed is 30,000 commentaries on classics, is prepared into microcapsule;
(6) microcapsule that step (5) is obtained makes arachidonic acid nutrition microcapsule with high temperature resistance through 90 ℃ of hot blast airpillow-dry.
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| Application Number | Priority Date | Filing Date | Title |
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| CN101559045B true CN101559045B (en) | 2011-05-25 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR089441A1 (en) | 2011-12-22 | 2014-08-20 | Baes Erik | GELATIN / ALGINATE CAPSULES OF DELAYED LIBERATION THAT INCLUDE OMEGA-3 FATTY ACIDS AND METHODS AND USES OF THE SAME, MANUFACTURE METHOD, PHARMACEUTICAL COMPOSITION |
| CN108430461B (en) * | 2015-10-12 | 2021-10-29 | 浙江医药股份有限公司新昌制药厂 | Preparation method of high-stability microcapsule dry powder/particles containing fat-soluble nutrients with more double bonds |
| CN106962915A (en) * | 2017-04-17 | 2017-07-21 | 江西省食品发酵研究所 | The Microencapsulation Method of Chinese yew ferment microencapsulated products and Chinese yew ferment |
| CN106962916A (en) * | 2017-04-17 | 2017-07-21 | 江西省食品发酵研究所 | The Microencapsulation Method of gingko ferment microencapsulated products and gingko ferment |
| CN106983138A (en) * | 2017-04-17 | 2017-07-28 | 江西省食品发酵研究所 | The Microencapsulation Method of maca ferment microencapsulated products and maca ferment |
| CN112450417B (en) * | 2020-11-12 | 2023-04-07 | 广州合诚三先生物科技有限公司 | Clausena lansium volatile oil microcapsule powder and preparation method thereof |
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|---|---|---|---|---|
| CN1357406A (en) * | 2001-10-31 | 2002-07-10 | 中国科学院新疆化学研究所 | Conjugate linoleate microcapsule |
| CN1387863A (en) * | 2002-06-07 | 2003-01-01 | 汕头市雅园生物工程有限公司 | Prepn process and use of heat-resisting nutritious microcapsule fish oil DHA powder |
| CN101125133A (en) * | 2007-09-27 | 2008-02-20 | 武汉麦可得生物技术有限公司 | Unsaturated fatty acid microcapsule preparing technology and application |
| CN101309746A (en) * | 2005-08-22 | 2008-11-19 | 塔格拉生物科技有限公司 | Method for production of single- and multi-layer microcapsules |
-
2009
- 2009-05-21 CN CN2009100277831A patent/CN101559045B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357406A (en) * | 2001-10-31 | 2002-07-10 | 中国科学院新疆化学研究所 | Conjugate linoleate microcapsule |
| CN1387863A (en) * | 2002-06-07 | 2003-01-01 | 汕头市雅园生物工程有限公司 | Prepn process and use of heat-resisting nutritious microcapsule fish oil DHA powder |
| CN101309746A (en) * | 2005-08-22 | 2008-11-19 | 塔格拉生物科技有限公司 | Method for production of single- and multi-layer microcapsules |
| CN101125133A (en) * | 2007-09-27 | 2008-02-20 | 武汉麦可得生物技术有限公司 | Unsaturated fatty acid microcapsule preparing technology and application |
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