CN101555436A - Method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia - Google Patents
Method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia Download PDFInfo
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- CN101555436A CN101555436A CNA2009101069696A CN200910106969A CN101555436A CN 101555436 A CN101555436 A CN 101555436A CN A2009101069696 A CNA2009101069696 A CN A2009101069696A CN 200910106969 A CN200910106969 A CN 200910106969A CN 101555436 A CN101555436 A CN 101555436A
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- camphor tree
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Abstract
The invention relates to a method for extracting active materials, in particular to a method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia. The method comprises the following steps of: 1) firstly crushing the antrodia cinnamomea mycelia into antrodia cinnamomea mycelia powder; 2) loading the crushed antrodia cinnamomea mycelia powder into an extraction kettle of a supercritical CO2 extraction device, adding ethanol-water mixed liquor as an entrainer, and putting the crushed antrodia cinnamomea mycelia powder into a separation kettle for separation after extraction; 3) separating the mixed liquor of the separated antrodia cinnamomea oil and the entrainer by a high-speed centrifugal device with the rotating speed being 5000-50000 circles to obtain the antrodia cinnamomea oil; and 4) collecting and weighing the separated extract, namely the antrodia cinnamomea oil. The method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia has the beneficial effects that: a method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia is provided, and the yield of extraction can reach 40%; and the method can be used for industrialized mass production, with relatively low cost compared with that of the method for extracting the antrodia cinnamomea oil from antrodia cinnamomea spores.
Description
Technical field
The present invention relates to a kind of method that extracts active substance, refer more particularly to a kind of method from Antrodia Camphorata mycelium extraction camphor tree sesame oil.
Background technology
The camphor tree sesame claims Antrodia camphorata, Cinnamomum kanahirai hay mushroom again, and formal name used at school is Antrodia camphorata, belongs to Aphyllophorales, perennial gill fungus mushroom, surperficial redness as smart as a new pin, in spore is arranged, its sporophore does not have stem, and intensive camphor tree fragrance is arranged, flavor is hot, bitter.The camphor tree sesame is the exclusive kind in Taiwan, and it is most precious medicinal material that the aboriginal all is considered as the camphor tree sesame, is " panacea " of treatment severe, liver cirrhosis.The whole world only is grown in the mountain area, Taiwan, and is between 450 to 2000 meters of height above sea level, century-old above and classify as on the Cinnamomum kanahirai hay tree of national treasure level child care class.At present the camphor tree sesame peach garden, Miaoshu, the south that mainly are distributed in China Taiwan throw. ground such as platform east and Kaohsiung, all the other regions are then very rare.The hollow director of camphor tree sesame wall within Cinnamomum kanahirai hay tree is rotten goes out, or the wet surface of Cinnamomum kanahirai hay shade undercurrent that withered volt falls grows, and is not easy to be found, and therefore is of great rarity.The camphor tree sesame has the yellow camphor tree fragrance of intensive, and outward appearance becomes tabular or stalactitic, back side chocolate, the outside of belly is beautiful orange, is poroid, in spore is arranged is the characteristic of primary camphor tree sesame.
In recent years, after the message that the camphor tree sesame has a magical curative effect spread out of, also when the river rises the boat goes up day by day for the price of natural wild camphor tree sesame, the most expensive wild fungus in the whole world of being known as at present, and market price does not wait up to more than 10 ten thousand yuan of every jin New Taiwan Currencies to hundreds thousand of units.Be worth and place oneself above out and away already on traditional high precious medicinal materials such as glossy ganoderma, genseng, Cordyceps sinensis, the king among the king in the medicinal material of therefore can saying so.
Contain multiple physiologically active ingredient in the camphor tree sesame, as polysaccharide, triterpene compound, sudismase (SOD) adenosine, protein (containing immune protein), multivitamin, trace element (calcium, phosphorus, paper mulberry), nucleic acid, lectin, amino acid, cholesterol, xylogen, blood pressure stabilization material etc.That it physiological active functions that possesses has is antitumor, strengthening immunity, antiviral, antianaphylaxis, hypertension, inhibition platelet aggregation, hypotensive, decreasing cholesterol, antibacterium, protection liver etc.
Based on the development of above-mentioned camphor tree sesame, now be badly in need of a kind of method that extracts camphor tree sesame oil, satisfy the continual renovation development of camphor tree sesame product.
Summary of the invention
The present invention is directed to above-mentioned the deficiencies in the prior art technical problem to be solved is: a kind of method from Antrodia Camphorata mycelium extraction camphor tree sesame oil is provided.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of method from Antrodia Camphorata mycelium extraction camphor tree sesame oil, this method may further comprise the steps:
1) earlier Antrodia Camphorata mycelium is crushed to 85～500 purpose Antrodia Camphorata mycelium powder;
2) supercritical CO of packing into of the Antrodia Camphorata mycelium powder after will pulverizing
2In the extraction kettle of extraction plant, and add the alcohol-water mixed solution as entrainment agent, the proportional range of alcohol-water is: ethanol: water=9.9: 0.1～0.1: 9.9, the weight of alcohol-water mixed solution is 0.01%～40% of Antrodia Camphorata mycelium grain weight amount, and the extracting pressure that makes extraction kettle is 10MPa～15Mpa; Extraction temperature is 30 ℃～65 ℃; CO
2Fluid flow rate is 40～120kg/h; The extraction time is 0.5h～48h, and enter separating still after the extraction and separate: the internal pressure of separation reactor I is 5MP～25MP, and temperature is 30 ℃～65 ℃; Separation reactor I I internal pressure is 6MP～15MP, and temperature is 20 ℃～50 ℃;
3) oil of the camphor tree sesame after will separating and entrainment agent mixed solution are that 5000～50000 high speed centrifugation devices that change separate through rotating speed, obtain camphor tree sesame oil;
4) will separate back extract camphor tree sesame oil collects and weighs.
The weight of described entrainment agent is 0.01%～9.99% of Antrodia Camphorata mycelium grain weight amount.
The weight of described entrainment agent is 20.01%～40% of Antrodia Camphorata mycelium grain weight amount.
Described Antrodia Camphorata mycelium extract camphor tree sesame oil yield is 6%～40%.
Described high speed centrifugation device rotary speed is 40001～50000 commentaries on classics.
The extracting pressure of described extraction kettle is 10MPa～15Mpa, and extraction temperature is 30 ℃～35 ℃.
Described CO
2Fluid flow rate is 40～60kg/h.
The described extraction time is 4h～48h.
The beneficial effect of a kind of method from Antrodia Camphorata mycelium extraction camphor tree sesame oil of the present invention is:
A kind of method from Antrodia Camphorata mycelium extraction camphor tree sesame oil is provided, and the oil yield of extraction can reach 40%, can be used for industrial mass production, the relative camphor tree Ganoderma lucidum spore extraction of cost is low, and its oil yield wants high with respect to the camphor tree Ganoderma lucidum spore, takes the intravital specific absorption in back than camphor tree Ganoderma lucidum spore height, the content of effective ingredient is than camphor tree Ganoderma lucidum spore height, for the exploitation of camphor tree sesame provides new channel and thinking,, improved value-added content of product for the human consumer provides new product.
Embodiment
The present invention implements like this:
Embodiment one:
Method from Antrodia Camphorata mycelium extraction camphor tree sesame oil may further comprise the steps:
1) earlier Antrodia Camphorata mycelium is crushed to 85 purpose Antrodia Camphorata mycelium powder;
2) supercritical CO of packing into of the Antrodia Camphorata mycelium powder after will pulverizing
2In the extraction kettle of extraction plant, and add the alcohol-water mixed solution as entrainment agent, the ratio of alcohol-water is: ethanol: water=9.9: 0.1, the weight of alcohol-water mixed solution are 0.01% of Antrodia Camphorata mycelium grain weight amount, and the extracting pressure of extraction kettle is 10MPa; Extraction temperature is 30 ℃; CO
2Fluid flow rate is 40kg/h; The extraction time is 0.6h, enters separating still after the extraction and separates, and the internal pressure of separation reactor I is 5MP, and temperature is 30 ℃; Separation reactor I I internal pressure is 6MP, and temperature is 20 ℃;
3) oil of the camphor tree sesame after will separating and entrainment agent mixed solution are that the 5000 high speed centrifugation devices that change separate through rotating speed, obtain camphor tree sesame oil;
4) will separate back extract camphor tree sesame oil collects and weighs.
Antrodia Camphorata mycelium extract camphor tree sesame oil yield is 30.8% in the present embodiment.
Embodiment two:
Method from Antrodia Camphorata mycelium extraction camphor tree sesame oil may further comprise the steps:
1) earlier Antrodia Camphorata mycelium is crushed to 130 purpose Antrodia Camphorata mycelium powder;
2) supercritical CO of packing into of the Antrodia Camphorata mycelium powder after will pulverizing
2In the extraction kettle of extraction plant, and add the alcohol-water mixed solution as entrainment agent, the ratio of alcohol-water is: ethanol: water=1: 1, the weight of alcohol-water mixed solution are 3% of Antrodia Camphorata mycelium grain weight amount, and the extracting pressure that makes extraction kettle is 14Mpa; Extraction temperature is 34 ℃; CO
2Fluid flow rate is 55kg/h; The extraction time is 5h, and enter separating still after the extraction and separate: the internal pressure of separation reactor I is 7MP, and temperature is 34 ℃; Separation reactor I I internal pressure is 11MP, and temperature is 24 ℃
3) oil of the camphor tree sesame after will separating and entrainment agent mixed solution are that the 15000 high speed centrifugation devices that change separate through rotating speed, obtain camphor tree sesame oil;
4) will separate back extract camphor tree sesame oil collects and weighs.
Antrodia Camphorata mycelium extract camphor tree sesame oil yield is 38% in the present embodiment.
Embodiment three:
Method from Antrodia Camphorata mycelium extraction camphor tree sesame oil may further comprise the steps:
1) earlier Antrodia Camphorata mycelium is crushed to 250 purpose Antrodia Camphorata mycelium powder;
2) supercritical CO of packing into of the Antrodia Camphorata mycelium powder after will pulverizing
2In the extraction kettle of extraction plant, and add the alcohol-water mixed solution as entrainment agent, the ratio of alcohol-water is: ethanol: water=1: 5, the weight of alcohol-water mixed solution are 21% of Antrodia Camphorata mycelium grain weight amount, and the extracting pressure that makes extraction kettle is 24Mpa; Extraction temperature is 55 ℃; CO
2Fluid flow rate is to be 12h the 85kg/h extraction time, and enter separating still after the extraction and separate: the internal pressure of separation reactor I is 14MP, and temperature is 45 ℃; Separation reactor I I internal pressure is 13MP, and temperature is 38 ℃;
3) oil of the camphor tree sesame after will separating and entrainment agent mixed solution are that the 25000 high speed centrifugation devices that change separate through rotating speed, obtain camphor tree sesame oil;
4) will separate back extract camphor tree sesame oil collects and weighs.
Antrodia Camphorata mycelium extract camphor tree sesame oil yield is 38.2% in the present embodiment.
Embodiment four:
Method from Antrodia Camphorata mycelium extraction camphor tree sesame oil may further comprise the steps:
1) earlier Antrodia Camphorata mycelium is crushed to 500 purpose Antrodia Camphorata mycelium powder;
2) supercritical CO of packing into of the Antrodia Camphorata mycelium powder after will pulverizing
2In the extraction kettle of extraction plant, and add the alcohol-water mixed solution as entrainment agent, the ratio of alcohol-water is: ethanol: water=0.1: 9.9, the weight of alcohol-water mixed solution are 40% of Antrodia Camphorata mycelium grain weight amount, and the extracting pressure that makes extraction kettle is 14.8Mpa; Extraction temperature is 65 ℃; CO
2Fluid flow rate is to be 48h the 120kg/h extraction time, and enter separating still after the extraction and separate: the internal pressure of separation reactor I is 25MP, and temperature is 65 ℃; Separation reactor I I internal pressure is 15MP, and temperature is 50 ℃;
3) oil of the camphor tree sesame after will separating and entrainment agent mixed solution are that the 50000 high speed centrifugation devices that change separate through rotating speed, obtain camphor tree sesame oil;
4) will separate back extract camphor tree sesame oil collects and weighs.
Antrodia Camphorata mycelium extract camphor tree sesame oil yield is 40% in the present embodiment.
The above, it only is a kind of preferred embodiment that extracts the method for camphor tree sesame oil from Antrodia Camphorata mycelium of the present invention, be not that technical scope of the present invention is imposed any restrictions, every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention above any trickle modification, equivalent variations and modification that embodiment did.
Claims (8)
1, a kind of method from Antrodia Camphorata mycelium extraction camphor tree sesame oil, this method may further comprise the steps:
1) earlier Antrodia Camphorata mycelium is crushed to 85～500 purpose Antrodia Camphorata mycelium powder;
2) supercritical CO of packing into of the Antrodia Camphorata mycelium powder after will pulverizing
2In the extraction kettle of extraction plant, add the alcohol-water mixed solution as entrainment agent, the proportional range of alcohol-water is in the alcohol-water mixed solution: 9.9: 0.1～0.1: 9.9, the weight of alcohol-water mixed solution is 0.01%～40% of Antrodia Camphorata mycelium grain weight amount, and the extracting pressure of extraction kettle is 10MPa～35Mpa; Extraction temperature is 30 ℃～65 ℃; CO
2Fluid flow rate is 40～120kg/h; The extraction time is 0.5h～48h, and enter separating still after the extraction and separate: the internal pressure of separation reactor I is 5MP～25MP, and temperature is 30 ℃～65 ℃; Separation reactor I I internal pressure is 7MP～15MP, and temperature is 20 ℃～50 ℃;
3) oil of the camphor tree sesame after will separating and entrainment agent mixed solution are that 5000～50000 high speed centrifugation devices that change separate through rotating speed, obtain camphor tree sesame oil;
4) will separate back extract camphor tree sesame oil collects and weighs.
2, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1, the weight that it is characterized in that described entrainment agent is 0.01%～9.99% of Antrodia Camphorata mycelium grain weight amount.
3, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1, the weight that it is characterized in that described entrainment agent is 20.01%～40% of Antrodia Camphorata mycelium grain weight amount.
4, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1 is characterized in that the yield of described Antrodia Camphorata mycelium extract camphor tree sesame oil is 6%～40%.
5, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1 is characterized in that described high speed centrifugation device rotary speed is 40001～50000 commentaries on classics.
6, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1, the extracting pressure that it is characterized in that described extraction kettle is 10MPa～15Mpa, extraction temperature is 30 ℃～35 ℃.
7, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1 is characterized in that described CO
2Fluid flow rate is 40～60kg/h.
8, the method from Antrodia Camphorata mycelium extraction camphor tree sesame oil according to claim 1 is characterized in that the described extraction time is 4h～48h.
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