CN1240400C - Method for producing supercritical extraction cordyceps sinensis oil - Google Patents
Method for producing supercritical extraction cordyceps sinensis oil Download PDFInfo
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- CN1240400C CN1240400C CN 01126909 CN01126909A CN1240400C CN 1240400 C CN1240400 C CN 1240400C CN 01126909 CN01126909 CN 01126909 CN 01126909 A CN01126909 A CN 01126909A CN 1240400 C CN1240400 C CN 1240400C
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- 238000000855 fermentation Methods 0.000 claims description 10
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a production method of supercritical extraction cordyceps sinensis oil, which solves the problem of harmful solvent residue in the traditional organic solvent extraction; the biological characteristics of natural aromatic components and cordyceps unsaturated fatty acids are kept; the environment is not polluted, and the operation is simple and convenient; becomes an important process in the production of food and medicine raw materials and reaches the international advanced level. The invention is technically characterized in that: the finished product of the cordyceps oil has specific spectral characteristics which are obviously different from those of an ether extraction reference product, and particularly, the physical properties of the finished product of the cordyceps oil and the ether extraction reference product are different at room temperature of 25-30 ℃; the former is transparent and fragrant, and the latter is opaque and has pungent smell. The product of the invention has the functions of antioxidation, beauty treatment and skin care, blood fat regulation, tendon relaxing and blood circulation promotion and mitochondrial function protection; can be used as raw material for food, cosmetic and medicine; in particular to a cordyceps sinensis oil soft capsule and compound cordyceps sinensis oil which can be applied in the fields of nutrition, health care and medical treatment.
Description
Technical field
The invention belongs to the deep processing field of edible medicinal fungi.
Background technology
Cordyceps sinensis fungus is precious edible medicinal fungi mostly, and the artificial culture development of technology makes rare wild fungus that the value of economic development arranged in recent years.Type sepecies one Cordyceps militaris (L.) Link. in the Cordyceps can carry out large scale cultivating, and the effective ingredient of its artificial finished product and pharmacological property can match in excellence or beauty with natural prodcuts, also have invigorating the lung and the kidney, the effect of relieving cough and resolving phlegm.So the many artificial culture products in the Cordyceps have precious edible medical value.Number of patent application 92101051.6 has been introduced their prospect and value.Wherein pluck the culture medium behind the Stroma, generally all go out of use, therefore, as the raw material effective component extracting, turning waste into wealth has significant values.
When the Chinese medicine extraction process, take decocting in water, alcohol extraction, steaming and decocting concentration technique more, energy consumption is big, operates loaded down with trivial detailsly, also has many refuses to cause environmental pollution.So adopting state-of-the-art technology to extract active skull cap components has huge economic and social value.And supercritical carbon dioxide extraction method just possesses the low temperature inert environments, does not influence the effective ingredient activity, and is nontoxic nonflammable, safe in utilization, do not pollute the environment no solvent residue, heavy metal free ion.Therefore, adopt supercritical technology to extract active component in the Cordyceps culture, create a kind of new technology, new method has practical value.
Summary of the invention
Purpose of the present invention, be that to overcome traditional organic reagent residual, adopt the supercritical technology extracting caterpillar fungus to belong to oils composition in the fungus artificial fermentation thing base material, make it become new raw material, new product in nourishing healthy and the medical field, and a kind of production method of super critical extracting caterpillar fungus oil is provided.
Technical scheme of the present invention is as follows.
A kind of production method of super critical extracting caterpillar fungus oil, be that artificial fermentation thing with the Cordyceps in the Cordyceps, Cordyceps militaris (L.) Link., Cordyceps hawkesii Gary, Cordyceps militaris (L.) Link. Paecilomyces varioti is a raw material, adopt supercritical carbon dioxide extraction method to obtain Cordyceps oil, treated again, batching, mixing, molding, packaging step are produced.
The raw material of supercritical extraction adopts Cordyceps militaris (L.) Link. artificial culture thing, and its water content is 6-55%.The optimum moisture content of described Cordyceps militaris (L.) Link. artificial culture thing is 6-10%.
Be solid material to be pulverized the back use, its granularity is the 20-60 order.The described granularity optimum of pulverizing the back solid material is 40 orders.
The pressure of extraction kettle is 15-50Mpa, and the pressure of separating still is 5-15Mpa; In same flow process, the former pressure is greater than the latter's pressure.
Can further form compound cordyceps preparation by Cordyceps oil, Cordyceps oil accounts for the 10-90% of percentage by weight in the preparation.
Describedly further be made up of in the compound cordyceps preparation Cordyceps oil, the preferable percentage by weight of Cordyceps oil is 20-80%.
Technical process of the present invention is as follows
Adopting solid or semisolid behind Cordyceps or the Cordyceps militaris (L.) Link. artificial culture be raw material, (comprise surplus stock behind the super critical extracting caterpillar fungus oil 〉, its water content is at 6-55%, all body raw materials of the best employing, water content is 6-10%.Raw material of the present invention is meant the product of bacterial strain behind artificial culture in Cordyceps and the Cordyceps.Do not comprise the qualification of bacterial strain strain in the right of the present invention, mainly be meant their solid or semi-solid product, as the culture medium of solid fermentation, the maize gruel culture medium of semisolid fermentation and the dry mycopowder behind the liquid fermentation.These products divide in preserving transportation at water content 6-10%.
The Cordyceps pool that the present invention produces, the granularity of its solid material are between the 20-60 order, and be best about 40 orders.As everyone knows, 350 kinds of bacterial strains, for example Cordyceps＜CodycepsSinerIsis are arranged in the Cordyceps 〉, Cordyceps militaris (L.) Link.＜Codyceps militaris, Cordyceps hawkesii Gary＜Coz-dycePSHawkesii, Cordyceps militaris (L.) Link. Paecilomyces varioti (PaecitweeSMUtarae) etc.These bacterial strains are seeded in through artificial culture can both be successful on the culture medium more than 50 kinds such as rice medium corn, Sorghum vulgare Pers., Semen Tritici aestivi, Semen setariae, Pupa bombycis, Antheraea pernyi Geurin Meneville, bat bat moth larvae, Ovum Gallus domesticus album, the difficult son peace body that forms of Cordyceps, Cordyceps militaris (L.) Link. more easily forms sporophore.Divide them into two classes like this: one is sporophore so long: two are fermented product＜culture medium, zymophyte powder 〉.The former can directly become commodity, list marketing, and the latter, as the Chinese caterpillar fungus fermentation mycopowder, Cordyceps militaris (L.) Link. mycopowder etc. can be made health food or medicine, Cordyceps militaris (L.) Link. rice medium＜bacterium base, bacterium slag that wherein volume of production is bigger 〉, do not utilize mostly.So the latter becomes primary raw material of the present invention.
In the technical application process, the bacterium culture will be pulverized the back and add in the extraction kettle, is advisable with the 20-60 order, too carefully easily stop up, too slightly the extraction time long easily residual, yield is low.The extraction of supercritical dioxy carbon is meant under condition of high voltage and makes carbon dioxide become liquid, as solvent, extracts the composition of Chinese crude drug, because stripping in still.In carbon dioxide flowed process, the pressure in the separating still, temperature difference analyzed required one-tenth.The Cordyceps pool at first is extracted out, and next is only deoxidation nuclear battalion class composition.
Method of the present invention, it is characterized in that adopting supercritical technology extracting caterpillar fungus oils effective ingredient, extraction kettle pressure 15-50Mpa: the separating still optimum pressure is 5-25Mpa, but in the same flow process separating still pressure all the time less than extraction kettle pressure.In general, adopting carbon dioxide flow in extraction kettle is 15-25 liter/h, and extraction kettle is got temperature about 50-60 ℃.Separating still pressure, temperature are according to required condition changing.
The technical characterictic that the technology of the present invention is produced is the Cordyceps militaris (L.) Link. oil of supercritical extraction, and is with the Cordyceps oil of extracted with diethyl ether, obviously different with the ultraviolet spectral analysis feature.(is example with the Cordyceps militaris (L.) Link.)
Description of drawings
Fig. 1 and Fig. 2 are the ultraviolet spectral analysis figure with extracted with diethyl ether.
The specific embodiment
As shown in the figure, scanning 240-440m, both absorbance differences of the first, it is of light color that supercritical methanol technology makes, and being apparent that at 300m has a trough, so the ratio of the ratio of 300/342m traditional method gained oil preparation 300/342m less than 1.Oz big 1.0.As everyone knows, be the ultraviolet spectra district less than 400m, be many material property spectral lines regions, therefore, differentiate the present technique feature with ultraviolet method, simple and easy to do have a certain sense.
The present technique invention product that obtains, the Cordyceps militaris (L.) Link. oil that it is characterized in that the z supercritical extraction is in a liquid state in the time of 20-30 ℃: and the Cordyceps militaris (L.) Link. oil that the traditional method of extracted with diethyl ether obtains is curdled appearance, shows both physical features differences.The former has kept the fragrance of natural component, and latter's spinosity nose abnormal smells from the patient.The former is faint yellow pellucidity, and viscosity is less than the latter.Be buff with the grease of extracted with diethyl ether and be at normal temperatures and solidify attitude, viscosity is big.After being heated to 50-60 ℃, can melt the attitude that is translucent in the impouring bottle, coagulation and opaque again after the cooling as Adeps Sus domestica.So, illustrate that both physical features have obvious difference.Certainly the latter can obtain the grease or the aroma ingredients of different conditions after fractional distillation, and that will be discussed certainly in addition, not within present technique discussion scope.
Because Cordyceps sinensis fungus value of the product costliness, the Cordyceps oil price that deep processing forms is high naturally.Because it has nourishing healthy and medical function, can form compound Chinese caterpillar fungus pool preparation with Chinese crude drugs such as Radix Salviae Miltiorrhizae, Flos Carthami, Radix Notoginseng, Radix Oenotherae erythrosepalaes, the feature of present technique product is the compound Chinese caterpillar fungus pool system tear that z is made up of the Cordyceps pool, Cordyceps oil accounts for the 10-90% of percentage by weight, and is best about 20-80%.
The grease of the Cordyceps sinensis fungus of present technique invention is the raw material of numerous food or medicine, therefore, has defined its physical features.Pharmacy of Chinese materia medica principle routinely; can be processed into series of products; a kind of method of the present invention's narration; it is characterized in that 2 soft capsules＜or drop pill and Cordyceps oil Emulsion contain the Cordyceps oil that supercritical methanol technology makes; every or every 10ml contain the 5-200mg Cordyceps oil; optimum content is the 10-100mg/ grain, or 10-100mg/10ml.
Contrast by product, think that the Cordyceps pool of present technique invention has following advantage: the structure that 1. keeps natural component in the raw material: 2. free from environmental pollution: 3. technical process is easily gone: but the equipment cost costliness: because of under high pressure conditions, moving, equipment requirements is tight: 4. through extracting the raw material after mooring, also can extract other composition.Therefore, we can say this technology to edible medicinal fungi deep processing, especially opened up a new page concerning the deep processing of the artificial fermentation thing of Cordyceps sinensis fungus, make it to become food, cosmetics and medicine important source material, the present invention has huge using value.
For embodiment the technology of the present invention process is described below
Embodiment one, takes by weighing 0.75 kilogram of Cordyceps militaris (L.) Link. rice medium, pulverizes the 20-60 mesh sieve, and is best about 40 orders, and in the extraction kettle of packing into 50 ℃, 35Mpa, 20L/h, the balance extraction of flowing after 15 minutes.Separating still pressure 5Mpa, 30 ℃, 2 hours post-samplings get the about 40ml of watery thing (lower floor 〉: the upper strata is a grease, about 10ml-12mlo with separatory funnel separate the Cordyceps oil 10ml of transparent fragrance.
Embodiment two, obtain Cordyceps oil 50ml by this law, adopt conventional method＜Fan Biting chief editor: pharmacy of Chinese materia medica, Science and Technology of Shanghai publishing house can 1997 one edition 202,356 pages, the preparation gelatin foil, reuse has two of the steel plates of semi-circular recesses, and manual compacting can get the soft capsule about 1000.Every contains the 40-50mg Cordyceps oil.
Embodiment three, by the Cordyceps oil 20ml that this law is produced, safflower oil 1ml, arabic gum 10g, cyclamate 0.1g, edible tween 80 10 grams add entry 100ml, grind in mortar, until becoming milky white liquid, add entry 1900ml again, continue grinding and be mixed into about opacifiers 2000ml, contain Cordyceps oil 90mg/10ml.
List of references
Respect soldier work: Cordyceps, the 23rd, 61,75,83 pages of Yunnan science and technology publishing house in JIUYUE, 1986 front pages.
Claims (4)
1, a kind of production method of super critical extracting caterpillar fungus oil, it is characterized in that: the artificial fermentation thing with Cordyceps sinensis fungus is a raw material, described Cordyceps sinensis fungus is selected from Cordyceps, Cordyceps militaris (L.) Link., Cordyceps hawkesii Gary or Cordyceps militaris (L.) Link. Paecilomyces varioti, adopt supercritical carbon dioxide extraction method to obtain Cordyceps oil, treated again, batching, mixing, molding, packaging step are produced; Solid material is pulverized the back use, granularity is the 20-60 order; The pressure of extraction kettle is 15-50Mpa, and the pressure of separating still is 5-15Mpa; In same flow process, the former pressure is greater than the latter's pressure.
2, method according to claim 1 is characterized in that: the raw material of supercritical extraction adopts Cordyceps militaris (L.) Link. artificial fermentation thing, and its water content is 6-55%.
3, method according to claim 1 and 2 is characterized in that: the water content of described Cordyceps militaris (L.) Link. artificial fermentation thing is 6-10%.
4, method according to claim 1 is characterized in that: the described granularity of pulverizing the back solid material is 40 orders.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01126909 CN1240400C (en) | 2001-09-28 | 2001-09-28 | Method for producing supercritical extraction cordyceps sinensis oil |
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| CN 01126909 CN1240400C (en) | 2001-09-28 | 2001-09-28 | Method for producing supercritical extraction cordyceps sinensis oil |
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| CN1240400C true CN1240400C (en) | 2006-02-08 |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100488521C (en) * | 2003-09-28 | 2009-05-20 | 李爱玲 | Extract, production and use of cordyceps sinensis |
| CN1330747C (en) * | 2005-03-09 | 2007-08-08 | 贵州大学 | Chinese caterpillar fungus oil extractum, its preparing method and use |
| CN1317376C (en) * | 2005-05-16 | 2007-05-23 | 柳元成 | Health wine containing pine, bamboo and plum |
| CN101045069B (en) * | 2007-04-10 | 2012-01-11 | 深圳市中科海外科技有限公司 | Method for extracting caterpillar fungus oil by using supercritical fluid of carbon dioxide |
| CN101077989B (en) * | 2007-06-19 | 2013-06-05 | 西北农林科技大学 | Supercritical extraction method for India truffle oil |
| CN101406491B (en) * | 2008-11-26 | 2011-04-06 | 吉林大学 | Oil-in-water Cordyceps sinensis emulsion and preparation technique |
| CN101555435B (en) * | 2009-05-15 | 2011-11-02 | 深圳市中科海外科技有限公司 | Method for extracting antrodia cinnamomea oil from antrodia cinnamomea fruiting bodies |
| CN101555436B (en) * | 2009-05-15 | 2011-07-20 | 深圳市中科海外科技有限公司 | Method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia |
| CN103497831B (en) * | 2013-10-22 | 2015-10-28 | 深圳市港科院生物有限公司 | A kind of production method of Cordyceps oil |
| CN104586902A (en) * | 2013-10-31 | 2015-05-06 | 江苏学府生物工程有限公司 | A method of producing cordyceps militaris-ganoderma spore powder soft capsule by a supercritical technique |
| CN104585742A (en) * | 2013-10-31 | 2015-05-06 | 江苏学府生物工程有限公司 | A compound cordyceps sinensis oil soft capsule production method |
| CN105087154A (en) * | 2015-09-07 | 2015-11-25 | 张恩光 | Technological method for extracting mulberry seed oil |
| CN107114490A (en) * | 2016-02-24 | 2017-09-01 | 王弘 | A kind of Cordyceps militaris vegetable oil and preparation method thereof |
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