CN1015509B - Tooth-protecting paste - Google Patents

Abstract

The present invention belongs to an oral cleaning agent, particularly to tooth protecting paste, a preparation method and a use method thereof. The tooth protecting paste is toothpaste for protecting teeth and preventing decayed tooth diseases from occurring and developing. The tooth protecting paste has reliable curative effect on decayed teeth and simultaneously has curative effect on gingivitis and allergic toothache. The tooth protecting paste has the advantages of scientific preparation, synergic comprehensive function of each component, sufficient exertion of the curative effect, simple and convenient use method, easy mastery, short curative course and obvious effect, and is suitable for all people to prevent and treat the decayed tooth diseases.

Description

Tooth-protecting paste

The invention belongs to cleaning agent for mouth cavity, especially a kind of tooth-protecting paste, and preparation method thereof and using method.

Commercially available all kinds of cleaning agent for mouth cavity have toothpaste, dentifrice, rinse water etc.Though they can remove the food debris of dental surface, cleaning oral cavity and tooth, the food debris removed easily of their teeth surfaces, and to those can stick to dental surface inflexibly or the transparent or thick dental caries in two dental groove cracks of hiding to gather speckle powerless.Commercially available all kinds of anticarious tooth paste all contains fluorine in various degree, and in the drinking-water of region-by-region not fluorinated volume height and life-time service it.Cause the high area of fluorinated volume in the drinking-water, form dental fluorosis (xanthodont).Even also there is the possibility that produces dental fluorosis in the low area of fluorinated volume in the drinking-water, life-time service toothpaste with fluoride.The composition of commercial toothpastes divides numerous and diverse, its mainly by toothbrush at dental surface fricting movement repeatedly, remove tartar by the abrasivus in the toothpaste, foaming agent (surfactant).When common people brushed teeth simultaneously, toothpaste and dental surface generally had one, two minute time of contact, and time of contact is of short duration, and the effective auti-cariosity material in the toothpaste is difficult to play one's part to the full, so its anti-caries weak effect is waited a moment.According to Zheng Yan, P228～233 of " cosmetics and the beauty treatment " that Li Fen writes (the Shandong People's Press publishes in August, 1986 a version) book are put down in writing, the prescription of comprehensive all kinds of commercial toothpastes is: antibacterial hibitane: 0.1～0.5%, fluoride: below 0.1%, calcium hydrogen phosphate: (dihydrate) 45% or calcium hydrogen phosphate anhydride: 2% or calcium pyrophosphate: 40% or calcium carbonate 48%, glycerol: 10～32%, sorbitol: 10%, carboxymethyl cellulose: 0.8～2%, sodium laurylsulfate: 2～3.2%, saccharin sodium: 0.01-0.4%, spice: 0.8～1.2%, aluminium-magnesium silicate: 2.0%, antiseptic (benzoic acids): an amount of, glucan glycolytic enzyme: an amount of, Purified Water: 14.3～29%.Write according to (day) Ikeda ferrum again, appoint P339～340 of " cosmetic conduct and learning " book of rhinoceros, Li Zhuanjia translations to be put down in writing, the method for making of toothpaste is: add carboxymethyl cellulose and swelling is dissolved it in Purified Water, other composition adds in the above-mentioned swelling liquid, fully mix, aerofluxus the toothpaste finished product.In the health that feeds intake, makes, must note in the overall process of production such as filling operator, equipment and environment.

Task of the present invention is the above-mentioned defective that overcomes commercial toothpastes, and a kind of tooth-protecting paste that prevents dental caries effectively is provided, and its prescription is simple, method for making advanced person, the preventing decayed tooth curative effect is reliable, short treating period, use nontoxic and other odontopathy (gingivitis, anaphylaxis have a toothache pain) is also had certain curative effect.

Solution of the present invention is following realization: develop a kind of tooth-protecting paste, it contains the antibacterial hibitane: 0.55～2.0%; Fluoride (sodium fluoride): 0.2～1.2%; Phosphate (sodium salt or potassium salt): 0.5～2.5%; Sodium carboxymethyl cellulose: 4.0～7.0%; Glycerol: 2.0～9.5%; Glucan glycolytic enzyme: 0.1～1.0%; Food coloring (carmine): 0.0047～0.0053%; Edible essence: an amount of (with sensory evaluation); The mixture of pulp with the Purified Water modulation.Saved materials such as synthos in this prescription, saved sodium laurylsulfate again, also saved benzoic acids as antiseptic as foaming agent as abrasivus.Because torpescence on the carboxymethyl cellulose physiology, all very stable to adaptability, the life perfume (or spice) of other composition, the proportioning that therefore enlarges carboxymethyl cellulose is 4～7%, thereby makes it become the main vehicle group composition of this tooth-protecting paste.And rely on hibitane, fluoride, glucan glycolytic enzyme, phosphatic coordination with the synthesis effect again, make tooth-protecting paste have anticariogenic special effective function.

The preparation method of this tooth-protecting paste is: accurately by prescription weighing antibacterial hibitane, fluoride, phosphate, glycerol, food coloring, saccharin sodium is put in the large beaker, add an amount of Purified Water and be heated to～100 ℃ of stirring and dissolving it; In addition accurately by prescription weighing sodium carboxymethyl cellulose, after putting into another small beaker and adding a small amount of Purified Water furnishing pulpous state, slowly pour into again in the above-mentioned large beaker, stir while pour into, boiled 2 minutes after treating all to add; Put after boiling when being chilled to 20 ℃～25 ℃ room temperatures, add glucan glycolytic enzyme and edible essence again; With the phosphate solution adjust pH 7.2～7.4; Be settled to the regulation scale with Purified Water at last, stir the finished product of tooth-protecting paste.More than operation needs to carry out in through the disinfectant operation room, and used container, equipment are filled in the container that is fit to use after sterilization and drying is handled, product-tooth-protecting paste.

The using method of this tooth-protecting paste is that tooth-protecting paste is squeezed on toothbrush, makes tooth-protecting paste fully contact each face of tooth by method for brushing teeth.Afterwards, keep the cream film to stop 3～5 minutes on Buccodental, so that the medicine in the cream film is brought into play its usefulness, the smart water of reuse is gargled.The whole course of treatment be nine times the coating, preceding four times weekly the coating once, back five times every month the coating once.In six months, dental caries is gathered speckle and will be removed like this, reaches tangible curative effect.

Tooth-protecting paste of the present invention, the outstanding consumption that has increased the wide-spectrum bactericide hibitane from preparation form to divide has just increased causing the inhibitory action of dental caries bacterium-Streptococcus mutans, and make tooth-protecting paste have preventing decayed tooth, antiinflammatory and desensitization effect so effectively.Preparation is formed in the branch has increased glucan glycolytic enzyme again, its collaborative hibitane biocide plays decomposition, makes that sticking to sticking on the tooth securely is that saccharide-dental caries is gathered speckle and taken off the synthetic insoluble sticking system sugar of Streptococcus mutans, thereby played the effect that reduces amount of bacterial plaque and its viscosity on enamel.Most important is that broad-spectrum biocide hibitane, fluoride, phosphate and glucan glycolytic enzyme are under the thickness carrier function of sodium carboxymethyl cellulose and the coordination with the synthesis effect, the improvement of adding method when using makes the cream film longer in the dental surface time of staying, the drug effect performance has fully reached the reliable purpose of curative effect.In six months, use this tooth-protecting paste, can reach curative effect.This tooth-protecting paste is applicable to man, woman, old, young caries prevention disease.Especially suitable to kindergarten and middle and elementary school student especially.This tooth-protecting paste is had a toothache to gingivitis, anaphylaxis also certain curative effect bitterly.

Embodiments of the invention are as follows:

In through disinfectant operation room, accurate weighing hibitane: 0.95 gram, sodium fluoride: 0.95 gram, sodium phosphate: 1.95 grams, glycerol: 3.5 grams, carmine: 0.005 restrains saccharin sodium: 0.015 gram, put into the 250ml beaker, add the 80ml Purified Water.Be heated to 95 ℃～100 ℃ stirrings and make it dissolving.Accurately weighing sodium carboxymethyl cellulose 4.5 grams are put into another one 100ml small beaker, add a small amount of Purified Water furnishing pulpous state, and slowly pour above-mentioned 250ml beaker limit edged into and stir, after all adding, boiled 2 minutes, and put again when being chilled to room temperature (20 ℃), add glucan glycolytic enzyme: 0.6 gram, edible essence (fruit type essence): 0.8 the gram (being as the criterion) with sensory evaluation, at last with Purified Water be settled to 100ml stir the tooth-protecting paste finished product.With the finished product tooth-protecting paste be fed in the container that sterilization and drying is handled the tooth-protecting paste product.

This tooth-protecting paste small-scale test is reported as follows: get 20 of stripped teeth; after soaking 24 hours with vinegar; make the enamel of tooth surface become coarse shape; be immersed in i.e. taking-up in 5 minutes in the tooth-protecting paste then; soaked once in 8 hours at every interval, soaks the result altogether 9 times: have to form the slick protective film of one deck on 18 facings; (other 2 teeth multiaspect are suffered from III degree dental caries, and tooth injury is excessive to be difficult to distinguish its effect.) its effective percentage reaches 90%.

Again this tooth-protecting paste is suffered from the have a toothache old people of pain of dental caries, gingivitis, anaphylaxis to five and carry out efficacy experiment.The patient at every turn with method for brushing teeth coating tooth-protecting paste on its tooth, protect the cream film in the oral cavity, to stop at every turn and gargled again in 5 minutes, once promptly take effect really after shared 5 times: dental caries anaphylaxis pain obviously alleviated in 5 days at interval, meet hot and cold, acid is all painless.

Claims (2)

1, a kind of tooth-protecting paste, it contains antibacterial hibitane, fluoride, phosphate, carboxymethyl cellulose, glycerol, glucosan alcoholysis enzyme, food coloring, saccharin sodium, edible essence, and with Purified Water modulation, it is characterized in that: the proportioning of tooth-protecting paste is: antibacterial hibitane: 0.55～2.0%; Fluoride (sodium fluoride): 0.2～1.2%; Phosphate (sodium salt or potassium salt): 0.5～2.5%; Sodium carboxymethyl cellulose: 4.0～7.0%; Glycerol: 2.0～9.5%; Glucosan alcoholysis enzyme: 0.1～1.0%; Food coloring (carmine): 0.0047～0.0053%; Edible essence: an amount of (with sensory evaluation); The mixture of pulp with the Purified Water modulation.

2, be that the preparation manipulation process needs carry out in through the disinfectant operation room according to the preparation method of the described tooth-protecting paste of claim 1, all use containers to be filled in the container after sterilization and drying is handled, product; Its operating process is characterised in that: accurately by prescription weighing hibitane, fluoride, phosphate, glycerol, food coloring, saccharin sodium is put in the large beaker, add an amount of Purified Water and be heated to 95 ℃～100 ℃ stirring and dissolving it; In addition accurately by prescription weighing sodium carboxymethyl cellulose, after putting into another small beaker and adding a small amount of Purified Water furnishing pulpous state, slowly pour into again in the above-mentioned large beaker, stir while pour into, boiled 2 minutes after treating all to add; Put after boiling when being chilled to 20 ℃～25 ℃ room temperatures, add glucan glycolytic enzyme and edible essence again; With the phosphate solution adjust pH 7.2～7.4; Use the Purified Water standardize solution at last, stir the tooth-protecting paste finished product.