CN101549125A - Pharmaceutical composition used for treating peculiar smell of oral cavity and preparation method thereof - Google Patents
Pharmaceutical composition used for treating peculiar smell of oral cavity and preparation method thereof Download PDFInfo
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- CN101549125A CN101549125A CNA2008101034014A CN200810103401A CN101549125A CN 101549125 A CN101549125 A CN 101549125A CN A2008101034014 A CNA2008101034014 A CN A2008101034014A CN 200810103401 A CN200810103401 A CN 200810103401A CN 101549125 A CN101549125 A CN 101549125A
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Abstract
The invention discloses a pharmaceutical composition used for treating peculiar smell of oral cavity and a preparation method thereof, and the active ingredients of the composition are prepared by extracting more than ten medicinal materials of Chinese angelica, Szechwan rhizoma coptidis, tree peony bark, largetrifoliolious bugbane rhizome, dried rehmannia root, dwarf lilyturf tuber, sharpleaf galangal fruit, villous amomum fruit, apricot kernel, Alpinia japonica, rhizoma pinellinae praeparata, galanga resurrectionlily rhizome, nardostachyos root and rhizome, nutgrass galingale rhizome, cassia bark, hawthorn fruit, liquoric root and the like. The unique medicinal active ingredients in the pharmaceutical composition have the efficacies of clearing stomach-fire, regulating intestine and nourishing stomach, so that the pharmaceutical composition is used for treating the peculiar smell of the oral cavity caused by gastrointestinal diseases.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for the treatment of halitosis and preparation method thereof.
Technical background
The halitosis disease is meant because of the internal body imbalance smelly dirty a kind of disease that causes giving vent to anger in the mouth.Show as when exhaling has obvious abnormal flavour more, and brushing teeth, gargling all is difficult to eliminate disease, uses cleaning agent all to be difficult to cover, and is one foul smell from inside.Person to person's contacts are more frequent in modern society, but most people have halitosis in various degree, and these halitosis patient is but to gargle after meal, to brush teeth or to eat the abnormal smells from the patient that chewing gum is alleviated halitosis.This all cures the symptoms, not the disease, and does not reach the radical cure purpose.
Raising along with the level of science and technology, life and civilization consciousness improves people to the understanding of halitosis harm.At present, to the understanding of halitosis harm, general view is thought and is mainly shown six aspects:
1, influences self mood
Psychology and Physiologic Studies show that pure and fresh implication has out and out influence to the secretory function of human hypothalamic hypophysis, also has a direct impact for nervous system.Experiment shows that it is happy that pure and fresh implication not only can be made us sensation, strengthens confidence, even can strengthen people's judgement.When darg and life be that never pure and fresh implication begins, be difficult to this people of the imagination and can obtain a satisfaction, repayment efficiently in this day.This also is the reason that a lot of people like fragrant mouthful foods such as chew gum.Just these methods all have a common defective: can only alleviate halitosis at that time, and can't effect a radical cure at the cause of disease.
2, influence self appetite.
Though the somebody is very inresponsive to the halitosis of self, among it is tangible unconscious, had influence on his appetite and gustatory glands function.
3, increase the weight of oral disease.
Investigation shows that the sickness rate of its oral disease of halitosis severe patient exceeds at least 50 times than ordinary person.
4, closely related with gastroenteropathy.
In the beginning of this century, though that medical circle is not also probed into fully to the underlying causes of gastroenteropathy and halitosis is clear, it has been found that the substantial connection of halitosis and gastroenteropathy: the overwhelming majority has gastroenteropathy among the halitosis person.
5, " the preceding post " of gastric cancer, stomach paralysis.
With the closely-related gastroenteropathy of halitosis in, the most serious is exactly gastric cancer, stomach paralysis.In investigation, find that these patients' halitosis has generally all reached degree of depth standard to gastric cancer, stomach paralysis patient.
6, influence social communication.
Though this harm seems with healthy irrelevant, the most serious harm in the halitosis person mind of accepting investigation on the contrary.Person to person's contacts more and more become a kind of necessary living means in the modern society, and the achievement that the people can obtain socially often depends on the height of the ability that he and people associate to a great extent.But halitosis has then seriously hindered person to person's contacts: application refused, work together keep off, neighbours dislike, the superior does not appreciate, the subordinate chokes with silent fury, lover " keeps at a distance ", child's " outspoken ", social life cold reception, family life estrangement.
The present invention is primarily aimed at owing to the caused halitosis of gastroenteropathy, and motherland's medical science thinks that halitosis is because stomach-fire is main, the long-pending heat of stomach internal organs, gastrointestinal dysfunction, dyspepsia, gastrointestinal hemorrhage, constipation etc. cause attack on the implication and wind-fire or damp and hot due to, also deficiency of kidney yin, hyperactivity of deficient fire.
Therefore, cure halitosis and must fall earlier stomach-fire clearly, transfer the intestinal nourishing the stomach, make the intestines and stomach recover normal, the food waste matter that is deposited on enteral is excreted, and eradicates first link that forms halitosis, gets well thereby cure halitosis.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen that is used for the treatment of halitosis.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Angelicae Sinensis 100-300 part Rhizoma Coptidis 100-300 part Cortex Moutan 100-300 part
Rhizoma Cimicifugae 80-240 part Radix Rehmanniae 80-240 part 100-300 Radix Ophiopogonis part
Fructus Alpiniae Oxyphyllae 100-300 part Fructus Amomi 80-240 part Semen Armeniacae Amarum 80-240 part
Alpinia japonica (Thunb.) Miq. 80-240 part Rhizoma Pinelliae Preparata 80-240 part Rhizoma Kaempferiae 80-240 part
Radix Et Rhizoma Nardostachyos 80-240 part Rhizoma Cyperi 100-300 part Cortex cinnamomi japonici (Ramulus Cinnamomi) 80-240 part
Fructus Crataegi 100-300 part Radix Glycyrrhizae 80-240 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 parts of Cortex Moutans of 200 parts of Rhizoma Coptidis of Radix Angelicae Sinensis
150 parts of 120 parts of Radix Rehmanniae of Rhizoma Cimicifugae 120 parts of Radix Ophiopogonis
120 parts in 80 parts of Semen Armeniacae Amarums of 150 parts of Fructus Amomis of Fructus Alpiniae Oxyphyllae
120 parts of 120 parts of Rhizoma Kaempferiae of 120 parts of Rhizoma Pinelliae Preparata of Alpinia japonica (Thunb.) Miq.
120 parts on 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of 80 portions of Rhizoma Cyperis of Radix Et Rhizoma Nardostachyos
120 parts in 150 portions of Radix Glycyrrhizaes of Fructus Crataegi
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Angelicae Sinensis adds 85% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape;
(2) medical materials such as all the other Rhizoma Coptidis, Cortex Moutan, Rhizoma Cimicifugae, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae, Fructus Amomi, Semen Armeniacae Amarum, Alpinia japonica (Thunb.) Miq., Rhizoma Pinelliae Preparata, Rhizoma Kaempferiae, Radix Et Rhizoma Nardostachyos, Rhizoma Cyperi, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Crataegi, Radix Glycyrrhizae add 10 times of decoctings and boil secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 3 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, just have entirely and fall stomach-fire clearly, transfer the effect of intestinal nourishing the stomach, be used for the caused halitosis of gastroenteropathy.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of tablet
1. write out a prescription:
150 parts of 150 parts of Cortex Moutans of 200 parts of Rhizoma Coptidis of Radix Angelicae Sinensis
150 parts of 120 parts of Radix Rehmanniae of Rhizoma Cimicifugae 120 parts of Radix Ophiopogonis
120 parts in 80 parts of Semen Armeniacae Amarums of 150 parts of Fructus Amomis of Fructus Alpiniae Oxyphyllae
120 parts of 120 parts of Rhizoma Kaempferiae of 120 parts of Rhizoma Pinelliae Preparata of Alpinia japonica (Thunb.) Miq.
120 parts on 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of 80 portions of Rhizoma Cyperis of Radix Et Rhizoma Nardostachyos
120 parts in 150 portions of Radix Glycyrrhizaes of Fructus Crataegi
2. preparation technology
(1) Radix Angelicae Sinensis adds 85% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape;
(2) medical materials such as all the other Rhizoma Coptidis, Cortex Moutan, Rhizoma Cimicifugae, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae, Fructus Amomi, Semen Armeniacae Amarum, Alpinia japonica (Thunb.) Miq., Rhizoma Pinelliae Preparata, Rhizoma Kaempferiae, Radix Et Rhizoma Nardostachyos, Rhizoma Cyperi, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Crataegi, Radix Glycyrrhizae add 10 times of decoctings and boil secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 3 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds starch, magnesium stearate, tabletting, promptly.
Embodiment 2: the preparation method of capsule
1. write out a prescription:
150 parts of 150 parts of Cortex Moutans of 200 parts of Rhizoma Coptidis of Radix Angelicae Sinensis
150 parts of 120 parts of Radix Rehmanniae of Rhizoma Cimicifugae 120 parts of Radix Ophiopogonis
120 parts in 80 parts of Semen Armeniacae Amarums of 150 parts of Fructus Amomis of Fructus Alpiniae Oxyphyllae
120 parts of 120 parts of Rhizoma Kaempferiae of 120 parts of Rhizoma Pinelliae Preparata of Alpinia japonica (Thunb.) Miq.
120 parts on 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of 80 portions of Rhizoma Cyperis of Radix Et Rhizoma Nardostachyos
120 parts in 150 portions of Radix Glycyrrhizaes of Fructus Crataegi
2. preparation technology
(1) Radix Angelicae Sinensis adds 85% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape;
(2) medical materials such as all the other Rhizoma Coptidis, Cortex Moutan, Rhizoma Cimicifugae, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae, Fructus Amomi, Semen Armeniacae Amarum, Alpinia japonica (Thunb.) Miq., Rhizoma Pinelliae Preparata, Rhizoma Kaempferiae, Radix Et Rhizoma Nardostachyos, Rhizoma Cyperi, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Crataegi, Radix Glycyrrhizae add 10 times of decoctings and boil secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 3 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds starch, and mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen that is used for the treatment of halitosis is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Angelicae Sinensis 100-300 part Rhizoma Coptidis 100-300 part Cortex Moutan 100-300 part
Rhizoma Cimicifugae 80-240 part Radix Rehmanniae 80-240 part 100-300 Radix Ophiopogonis part
Fructus Alpiniae Oxyphyllae 100-300 part Fructus Amomi 80-240 part Semen Armeniacae Amarum 80-240 part
Alpinia japonica (Thunb.) Miq. 80-240 part Rhizoma Pinelliae Preparata 80-240 part Rhizoma Kaempferiae 80-240 part
Radix Et Rhizoma Nardostachyos 80-240 part Rhizoma Cyperi 100-300 part Cortex cinnamomi japonici (Ramulus Cinnamomi) 80-240 part
Fructus Crataegi 100-300 part Radix Glycyrrhizae 80-240 part
2, a kind of drug regimen that is used for the treatment of halitosis according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 150 parts of Cortex Moutans of 200 parts of Rhizoma Coptidis of Radix Angelicae Sinensis
150 parts of 120 parts of Radix Rehmanniae of Rhizoma Cimicifugae 120 parts of Radix Ophiopogonis
120 parts in 80 parts of Semen Armeniacae Amarums of 150 parts of Fructus Amomis of Fructus Alpiniae Oxyphyllae
120 parts of 120 parts of Rhizoma Kaempferiae of 120 parts of Rhizoma Pinelliae Preparata of Alpinia japonica (Thunb.) Miq.
120 parts on 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of 80 portions of Rhizoma Cyperis of Radix Et Rhizoma Nardostachyos
120 parts in 150 portions of Radix Glycyrrhizaes of Fructus Crataegi
3, according to the described a kind of drug regimen that is used for the treatment of halitosis of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Angelicae Sinensis adds 85% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape;
(2) medical materials such as all the other Rhizoma Coptidis, Cortex Moutan, Rhizoma Cimicifugae, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae, Fructus Amomi, Semen Armeniacae Amarum, Alpinia japonica (Thunb.) Miq., Rhizoma Pinelliae Preparata, Rhizoma Kaempferiae, Radix Et Rhizoma Nardostachyos, Rhizoma Cyperi, Cortex cinnamomi japonici (Ramulus Cinnamomi), Fructus Crataegi, Radix Glycyrrhizae add 10 times of decoctings and boil secondary, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 3 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as sheet, capsule.
4, according to any one described a kind of drug regimen that is used for the treatment of halitosis among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for the treatment of halitosis of claim 3-4, it is characterized in that this Chinese medicine composition can be made into different preparations such as sheet, capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101034014A CN101549125A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition used for treating peculiar smell of oral cavity and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101034014A CN101549125A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition used for treating peculiar smell of oral cavity and preparation method thereof |
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| CN101549125A true CN101549125A (en) | 2009-10-07 |
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| CNA2008101034014A Pending CN101549125A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition used for treating peculiar smell of oral cavity and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435514A (en) * | 2014-11-25 | 2015-03-25 | 四川金堂海纳生物医药技术研究所 | Orally-taken medicine for treating infantile breath-holding spell syndrome and preparation method thereof |
| CN105533045A (en) * | 2015-12-29 | 2016-05-04 | 广西佳禾食品有限责任公司 | Rhizoma pinelliae preparata containing bad breath removing tea bag and preparation method thereof |
| CN106075274A (en) * | 2016-08-15 | 2016-11-09 | 欧卉 | A kind of Chinese medicine formula treating mouth odor |
-
2008
- 2008-04-03 CN CNA2008101034014A patent/CN101549125A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435514A (en) * | 2014-11-25 | 2015-03-25 | 四川金堂海纳生物医药技术研究所 | Orally-taken medicine for treating infantile breath-holding spell syndrome and preparation method thereof |
| CN105533045A (en) * | 2015-12-29 | 2016-05-04 | 广西佳禾食品有限责任公司 | Rhizoma pinelliae preparata containing bad breath removing tea bag and preparation method thereof |
| CN106075274A (en) * | 2016-08-15 | 2016-11-09 | 欧卉 | A kind of Chinese medicine formula treating mouth odor |
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Open date: 20091007 |