CN101531608A - Method for preparing easily dissolved zinc glycine - Google Patents
Method for preparing easily dissolved zinc glycine Download PDFInfo
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- CN101531608A CN101531608A CN200910030766A CN200910030766A CN101531608A CN 101531608 A CN101531608 A CN 101531608A CN 200910030766 A CN200910030766 A CN 200910030766A CN 200910030766 A CN200910030766 A CN 200910030766A CN 101531608 A CN101531608 A CN 101531608A
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Abstract
The invention discloses a method for preparing easily dissolved zinc glycine, which comprises the following steps: respectively taking 15 to 15 weight percent of glycin, 5 to 10 weight percent of zinc oxide and 76 to 80 weight percent of water, mixing and stirring the raw materials in a reaction kettle to make the raw materials fully dissolved, performing reaction for 3 to 24 hours by heating at a temperature between 50 and 80 DEG C, and then standing for 6 to 10 hours; taking reaction solution, and centrifugating the reaction solution at a rotating speed between 3,000 and 8,000 turn/minute, taking sedimentation by the centrifuging, drying the sedimentation at a temperature between 80 and 120 DEG C in an oven to obtain a dry substance; and crushing the dry substance, passing through a 80 to 120-mesh sieve, performing sterilizing and split charging. The method for preparing the zinc glycine has easily obtained raw material used, scientific and reasonable mixture ratio of the raw materials, simple preparation process, high yield of the synthesized zinc glycine, low cost and suitability for industrial production.
Description
Technical field
The invention discloses a kind of preparation method of compound, specifically disclose a kind of preparation method of easily dissolved zinc glycine.
Background technology
China's different ages, the crowd of different occupation, zinc intake is generally on the low side, the average amount of taking in zinc for each person every day only recommends to take in about 50% of zinc amount for Chinese Soclety of Nutrition, the phenomenon of the scarce zinc of children and teenager is even more serious, there are 50% to 60% children and teen-age zinc intake not to reach and recommend 50% of feed rate, zinc is one of 14 kinds of essential in human body trace elements, it has important biological function, growth to the people, growth has vital role, and zinc can enhancing body immunizing power and the normal development of assurance reproduction function and the metabolism of promotion cholesterol and high-density lipoprotein (HDL).
The human body zinc supplementation product of present domestic use, major part is the inorganic zinc of the first-generation and the common organic salt zinc of the s-generation, wherein first-generation zinc supplementation agent, actual is exactly zinc oxide or zinc carbonate, all be ionic condition, very big to gastric irritation, and the zinc nutrition that replenishes is difficult to absorb, as life-time service or excessively be easy to cause calculi in vivo or maldigestion, s-generation zinc supplementation agent (common organic salt zinc supplementation agent), this type of zinc is generally: zinc lactate, glucose zinc or zinc glycyrrhizate etc. generally have only 30% or lower in the intravital specific absorption of people, compare with first kind product not have much improvement.Zinc glycinate is a kind of small molecules organic zinc of biologically active, but present zinc glycinate is poorly soluble, and the human absorptivity is lower, and the preparation method of zinc glycinate at present, and the synthetic ratio of finished product is low, complex process, and cost is higher.
Summary of the invention
Goal of the invention: the objective of the invention is provides the preparation method of the simple easily dissolved zinc glycine of a kind of technology in order to solve the deficiencies in the prior art.
Summary of the invention:
For realizing purpose of the present invention, the preparation method of easily dissolved zinc glycine provided by the invention may further comprise the steps:
(1) gets glycine, zinc oxide, water respectively and in reactor, mix, stir and make abundant dissolving,, left standstill 6 to 10 hours 50 to 80 ℃ of following reacting by heating 3 to 24 hours;
(2) get the reaction solution of step (1) gained, solid-liquid separation, solids;
(3) get step (2) gained solids, dry, dry thing;
(4) get step (3) gained dry thing, pulverizing, cross 80 to 120 mesh sieves, sterilization, packing.
Wherein the weight percent of the used glycine of step (1) is that the weight percent of 5-15%, zinc oxide is that the weight percent of 5-10%, water is 76-80%.
As another program wherein the weight percent of the described glycine of step (1) be that the weight percent of 7-10%, zinc oxide is that the weight percent of 3-7%, water is 84-88%.
Weight ratio as glycine used in the preferred version step (1), zinc oxide, water three is 0.7:0.3:9, and temperature of reaction is 60 ℃, and the reaction times is 12 hours.
Weight ratio as glycine used in another preferred version step (1), zinc oxide, water three is 0.8:0.4:8.8, and temperature of reaction is 80 ℃, and the reaction times is 16 hours.
The used zinc oxide of preparation method's step (1) of easily dissolved zinc glycine provided by the invention is Nano-class zinc oxide, and used water is pure water or redistilled water.
Wherein the solid-liquid separating method described in the step (2) is centrifugal, and centrifugal rotation speed is 3000 to 8000 rev/mins, and centrifugation time is 30 minutes to 2 hours, is 5000 rev/mins as the rotating speed in the preferred version step (2), and centrifugation time is 2 hours.
The preparation method of the easily dissolved zinc glycine provided by the invention wherein temperature of step (3) oven dry is 80 to 120 ℃, and step (4) is pulverized the back and crossed 100 mesh sieves.
Beneficial effect: used raw material is easy to get in the method for preparing easily dissolved zinc glycine provided by the invention, proportioning is scientific and reasonable between the raw material, through lot of experiments, generate the productive rate height of zinc glycinate when glycine provided by the invention, zinc oxide, water three's weight ratio 0.8:0.4:8.8 or 0.7:0.3:9.It is Nano-class zinc oxide that the present invention prepares the zinc oxide that the method for zinc glycinate selects for use, with higher behind the synthetic zinc glycinate of glycine the human absorptivity, and the preparation technology of reaction is simple, the productive rate height of synthetic zinc glycinate, cost is lower, be fit to suitability for industrialized production, the zinc glycinate that obtains by preparation method of the present invention is that two glycine and a zine ion bonded inner complex are arranged, in human intestinal not can because of with food in oxalic acid, the combination of acidic substance such as humic acid and loss, and having superior Bc, is the effective carrier as zine ion, can be by the biologically active substance that allows after the cytolemma identification to pass through, very permeable is crossed cytolemma on the intestines, directly absorbed by enteron aisle, the bioavailability height, and can not cause calculosis therefrom, the blood zinc level is stable, better tolerance has no adverse reaction.
Description of drawings
Accompanying drawing is the process flow sheet of preparation easily dissolved zinc glycine.
Embodiment:
Below in conjunction with specific embodiment, further illustrate the present invention, should understand these embodiment only is used to the present invention is described and is not used in and limit the scope of the invention, after having read the present invention, those skilled in the art all fall within the application's claims institute restricted portion to the modification of the various equivalent form of values of the present invention.
Embodiment 1
Get raw material glycine 50kg, Nano-class zinc oxide 50kg and water 760kg, put in the reactor and mix, stir and make abundant dissolving, reaction is 6 hours under 50 ℃ of temperature, extracts reaction solution, and leaves standstill 8 hours; Under 3000 rev/mins rotating speed centrifugal 1 hour, get centrifugal gained precipitation, place in the baking oven 80 ℃ of oven dry down, detect moisture content, make the moisture weight percentage be lower than 9%, dry thing 89kg, get dry thing, pulverizing, cross 100 mesh sieves, sterilization, packing.
Embodiment 2
Get raw material glycine 150kg, Nano-class zinc oxide 100kg and water 800kg, put in the reactor and mix, stir and make abundant dissolving, reaction is 12 hours under 80 ℃ of temperature, extracts reaction solution, and leaves standstill 6 hours; Under 5000 rev/mins rotating speed centrifugal 2 hours, get centrifugal gained precipitation, place in the baking oven 120 ℃ of oven dry down, detect moisture content, make the moisture weight percentage be lower than 9%, dry thing 238kg, get dry thing, pulverizing, cross 80 mesh sieves, sterilization, packing.
Embodiment 3
Get raw material glycine 70kg, Nano-class zinc oxide 30kg and water 900kg, put in the reactor and mix, stir and make abundant dissolving, reaction is 18 hours under 70 ℃ of temperature, extracts reaction solution, and leaves standstill 6 hours; Under 5000 rev/mins rotating speed centrifugal 1 hour, get centrifugal gained precipitation, place in the baking oven 100 ℃ of oven dry down, detect moisture content, make the moisture weight percentage be lower than 9%, dry thing 93kg, get dry thing, pulverizing, cross 120 mesh sieves, sterilization, packing.
Embodiment 4
Get raw material glycine 80kg, Nano-class zinc oxide 40kg and water 880kg, put in the reactor and mix, stir and make abundant dissolving, reaction is 24 hours under 60 ℃ of temperature, extracts reaction solution, and leaves standstill 3 hours; Under 8000 rev/mins rotating speed centrifugal 1.5 hours, get centrifugal gained precipitation, place in the baking oven 105 ℃ of oven dry down, detect moisture content, make the moisture weight percentage be lower than 9%, dry thing 112kg, get dry thing, pulverizing, cross 100 mesh sieves, sterilization, packing.
Embodiment 5
Get raw material glycine 90kg, Nano-class zinc oxide 50kg and water 860kg, put in the reactor and mix, stir and make abundant dissolving, reaction is 12 hours under 70 ℃ of temperature, extracts reaction solution, and leaves standstill 5 hours; Under 6000 rev/mins rotating speed centrifugal 1 hour, get centrifugal gained precipitation, place in the baking oven 105 ℃ of oven dry down, detect moisture content, make the moisture weight percentage be lower than 9%, dry thing 142kg, get dry thing, pulverizing, cross 100 mesh sieves, sterilization, packing.
Claims (10)
1, a kind of preparation method of easily dissolved zinc glycine is characterized in that may further comprise the steps:
(1) gets glycine, zinc oxide, water respectively and in reactor, mix, stir and make abundant dissolving,, left standstill 6 to 10 hours 50 to 80 ℃ of following reacting by heating 3 to 24 hours;
(2) get the reaction solution of step (1) gained, solid-liquid separation, solids;
(3) get step (2) gained solids, dry, dry thing;
(4) get step (3) gained dry thing, pulverizing, cross 80 to 120 mesh sieves, sterilization, packing.
2, the preparation method of easily dissolved zinc glycine according to claim 1 is characterized in that: the weight percent of the described glycine of step (1) is that the weight percent of 5-15%, zinc oxide is that the weight percent of 5-10%, water is 76-80%.
3, the preparation method of easily dissolved zinc glycine according to claim 2 is characterized in that: the weight percent of the described glycine of step (1) is that the weight percent of 7-10%, zinc oxide is that the weight percent of 3-7%, water is 84-88%.
4, the preparation method of easily dissolved zinc glycine according to claim 3 is characterized in that: used glycine, zinc oxide, water three's weight ratio is 0.7:0.3:9 in the step (1), and temperature of reaction is 60 ℃, and the reaction times is 12 hours.
5, the preparation method of easily dissolved zinc glycine according to claim 3 is characterized in that: used glycine, zinc oxide, water three's weight ratio is 0.8:0.4:8.8 in the step (1), and temperature of reaction is 80 ℃, and the reaction times is 16 hours.
6, according to the preparation method of each described easily dissolved zinc glycine of claim 1 to 5, it is characterized in that: used zinc oxide is Nano-class zinc oxide in the step (1).
7, the preparation method of easily dissolved zinc glycine according to claim 1 is characterized in that: the solid-liquid separating method described in the step (2) is centrifugal, and centrifugal rotation speed is 3000 to 8000 rev/mins, and centrifugation time is 30 minutes to 2 hours.
8, the preparation method of easily dissolved zinc glycine according to claim 7 is characterized in that: the rotating speed in the step (2) is 5000 rev/mins, and centrifugation time is 2 hours.
9, the preparation method of easily dissolved zinc glycine according to claim 1 is characterized in that: the temperature of step (3) oven dry is 80 to 120 ℃.
10, the preparation method of easily dissolved zinc glycine according to claim 1 is characterized in that: step (4) is pulverized the back and is crossed 100 mesh sieves.
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| CN200910030766A CN101531608A (en) | 2009-04-15 | 2009-04-15 | Method for preparing easily dissolved zinc glycine |
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| CN200910030766A CN101531608A (en) | 2009-04-15 | 2009-04-15 | Method for preparing easily dissolved zinc glycine |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101914851A (en) * | 2010-08-02 | 2010-12-15 | 孙伟 | Antibacterial agent and preparation method of antibacterial nonwoven cloth |
| DE102011011924A1 (en) | 2011-02-17 | 2012-08-23 | Isf Gmbh | Process for the preparation of amino acid chelate compounds, amino acid chelate compounds and use of amino acid chelate compounds |
| CN103025830A (en) * | 2010-07-23 | 2013-04-03 | 日产化学工业株式会社 | Crystalline resin composition |
| CN103922954A (en) * | 2014-04-02 | 2014-07-16 | 哈尔滨德邦鼎立生物科技有限公司 | Method for preparing glycine zinc chelate |
| CN108383746A (en) * | 2018-04-26 | 2018-08-10 | 江西和泽生物科技有限公司 | A kind of preparation method of glycine zine chelate |
| CN115160168A (en) * | 2022-08-11 | 2022-10-11 | 长沙兴嘉生物工程股份有限公司 | Zinc glycinate crystal and preparation method and application thereof |
-
2009
- 2009-04-15 CN CN200910030766A patent/CN101531608A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103025830A (en) * | 2010-07-23 | 2013-04-03 | 日产化学工业株式会社 | Crystalline resin composition |
| CN103025830B (en) * | 2010-07-23 | 2017-03-29 | 日产化学工业株式会社 | Crystalline resin composition |
| CN101914851A (en) * | 2010-08-02 | 2010-12-15 | 孙伟 | Antibacterial agent and preparation method of antibacterial nonwoven cloth |
| DE102011011924A1 (en) | 2011-02-17 | 2012-08-23 | Isf Gmbh | Process for the preparation of amino acid chelate compounds, amino acid chelate compounds and use of amino acid chelate compounds |
| CN103922954A (en) * | 2014-04-02 | 2014-07-16 | 哈尔滨德邦鼎立生物科技有限公司 | Method for preparing glycine zinc chelate |
| CN108383746A (en) * | 2018-04-26 | 2018-08-10 | 江西和泽生物科技有限公司 | A kind of preparation method of glycine zine chelate |
| CN115160168A (en) * | 2022-08-11 | 2022-10-11 | 长沙兴嘉生物工程股份有限公司 | Zinc glycinate crystal and preparation method and application thereof |
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Application publication date: 20090916 |