CN101524351A - 使用ice抑制剂治疗感染疾病 - Google Patents
使用ice抑制剂治疗感染疾病 Download PDFInfo
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- CN101524351A CN101524351A CN200910128642A CN200910128642A CN101524351A CN 101524351 A CN101524351 A CN 101524351A CN 200910128642 A CN200910128642 A CN 200910128642A CN 200910128642 A CN200910128642 A CN 200910128642A CN 101524351 A CN101524351 A CN 101524351A
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- ice
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- ciprofloxacin
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
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- Virology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US52636203P | 2003-12-01 | 2003-12-01 | |
| US60/526,362 | 2003-12-01 |
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| CNA2004800398687A Division CN1901892A (zh) | 2003-12-01 | 2004-12-01 | 使用ice抑制剂治疗感染疾病 |
Publications (1)
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| CN101524351A true CN101524351A (zh) | 2009-09-09 |
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| CN200910128642A Pending CN101524351A (zh) | 2003-12-01 | 2004-12-01 | 使用ice抑制剂治疗感染疾病 |
| CNA2004800398687A Pending CN1901892A (zh) | 2003-12-01 | 2004-12-01 | 使用ice抑制剂治疗感染疾病 |
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| CNA2004800398687A Pending CN1901892A (zh) | 2003-12-01 | 2004-12-01 | 使用ice抑制剂治疗感染疾病 |
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| US (1) | US20050233974A1 (https=) |
| EP (1) | EP1696894A1 (https=) |
| JP (1) | JP2007513092A (https=) |
| CN (2) | CN101524351A (https=) |
| AU (1) | AU2004294343A1 (https=) |
| CA (1) | CA2547670A1 (https=) |
| WO (1) | WO2005053665A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005115362A1 (en) * | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
| CA2567080A1 (en) * | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| CN101534824A (zh) * | 2006-11-17 | 2009-09-16 | 艾博特公司 | 作为化学活素受体拮抗剂的氨基吡咯烷 |
| WO2011094426A1 (en) | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
| EP4225301A1 (en) * | 2020-10-07 | 2023-08-16 | Institut National de la Santé et de la Recherche Médicale | Treatments of coronavirus infections, cytokine release syndrome, cytokine storm syndrome, or diseases associated with excessive activation of inflammasomes by the use of inhibitors of inflammatory caspases |
| FR3114741A1 (fr) * | 2020-10-07 | 2022-04-08 | Etienne Jacotot | Traitements des infections à coronavirus, du syndrome de libération de cytokine, du syndrome de la tempête de cytokines ou des maladies associées à l'activation excessive des inflammasomes par l'utilisation d'inhibiteurs des caspases inflammatoires. |
| CN116041418A (zh) * | 2021-10-28 | 2023-05-02 | 苏州裕泰医药科技有限公司 | 羟脯氨酰基-丝氨酸化合物及其制备方法和应用 |
| CN116041419B (zh) * | 2021-10-28 | 2025-12-12 | 苏州裕泰医药科技有限公司 | 羟脯氨酰基-丝氨酸化合物及其制备和应用 |
Family Cites Families (8)
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| US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| TWI243828B (en) * | 1998-03-19 | 2005-11-21 | Vertex Pharma | Inhibitors of caspases |
| US6201118B1 (en) * | 1998-08-19 | 2001-03-13 | Vertex Pharmaceuticals Inc. | Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor |
| PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| US20030096737A1 (en) * | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| EP1542768A1 (en) * | 2002-09-20 | 2005-06-22 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| TW200509958A (en) * | 2003-02-14 | 2005-03-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
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- 2004-12-01 CA CA002547670A patent/CA2547670A1/en not_active Abandoned
- 2004-12-01 WO PCT/US2004/040345 patent/WO2005053665A1/en not_active Ceased
- 2004-12-01 US US11/002,734 patent/US20050233974A1/en not_active Abandoned
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- 2004-12-01 JP JP2006541503A patent/JP2007513092A/ja active Pending
Also Published As
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|---|---|
| WO2005053665A1 (en) | 2005-06-16 |
| EP1696894A1 (en) | 2006-09-06 |
| US20050233974A1 (en) | 2005-10-20 |
| CN1901892A (zh) | 2007-01-24 |
| AU2004294343A1 (en) | 2005-06-16 |
| JP2007513092A (ja) | 2007-05-24 |
| CA2547670A1 (en) | 2005-06-16 |
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