CN101522202B - 通过颅内递送sirna治疗亨廷顿氏舞蹈症的组合物、装置和方法 - Google Patents

通过颅内递送sirna治疗亨廷顿氏舞蹈症的组合物、装置和方法 Download PDF

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CN101522202B
CN101522202B CN2007800371052A CN200780037105A CN101522202B CN 101522202 B CN101522202 B CN 101522202B CN 2007800371052 A CN2007800371052 A CN 2007800371052A CN 200780037105 A CN200780037105 A CN 200780037105A CN 101522202 B CN101522202 B CN 101522202B
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sirna
cell
rna
sequence
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CN101522202A (zh
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威廉姆·F·卡恩米勒
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Medtronic Inc
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN2007800371052A 2006-08-08 2007-08-08 通过颅内递送sirna治疗亨廷顿氏舞蹈症的组合物、装置和方法 Expired - Fee Related CN101522202B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/501,147 US7732591B2 (en) 2003-11-25 2006-08-08 Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
US11/501,147 2006-08-08
PCT/US2007/017659 WO2008021149A2 (en) 2006-08-08 2007-08-08 Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna

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CN101522202A CN101522202A (zh) 2009-09-02
CN101522202B true CN101522202B (zh) 2013-03-06

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CN2007800371052A Expired - Fee Related CN101522202B (zh) 2006-08-08 2007-08-08 通过颅内递送sirna治疗亨廷顿氏舞蹈症的组合物、装置和方法

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US (1) US7732591B2 (OSRAM)
EP (1) EP2056840B1 (OSRAM)
JP (1) JP2010500357A (OSRAM)
CN (1) CN101522202B (OSRAM)
CA (1) CA2660153C (OSRAM)
WO (1) WO2008021149A2 (OSRAM)

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US9375440B2 (en) * 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
US8173614B2 (en) * 2007-01-03 2012-05-08 Medtronic, Inc. Therapeuting compositions comprising an RNAi agent and a neurotrophic factor and methods of use thereof
WO2011008982A1 (en) * 2009-07-15 2011-01-20 Sah Dinah W Y Treatment of neurological disorders
EP3113612A4 (en) * 2014-03-05 2017-11-29 Humanetics Corporation Predicting and reducing cognitive decline based on gsk-3 levels
US10786674B2 (en) * 2016-03-08 2020-09-29 Medtronic, Inc. Medical therapy target definition
JOP20190104A1 (ar) 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن atxn3
WO2019161034A1 (en) * 2018-02-14 2019-08-22 Neuroelectrics Corporation Systems and methods for treating brain disease using targeted neurostimulation
SG11202010215TA (en) * 2018-05-09 2020-11-27 Ionis Pharmaceuticals Inc Compounds and methods for reducing atxn3 expression
CN114728018B (zh) * 2019-11-01 2024-07-19 阿尔尼拉姆医药品有限公司 亨廷顿(HTT)iRNA药剂组合物及其使用方法
CN113846122B (zh) * 2021-08-16 2023-08-25 中国医学科学院医学生物学研究所 一种过表达snca的腺相关病毒载体aav-snca、制备方法及其应用

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