CN101507432B - Carvacrol micro-emulsion and production technique thereof - Google Patents
Carvacrol micro-emulsion and production technique thereof Download PDFInfo
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- CN101507432B CN101507432B CN 200910074065 CN200910074065A CN101507432B CN 101507432 B CN101507432 B CN 101507432B CN 200910074065 CN200910074065 CN 200910074065 CN 200910074065 A CN200910074065 A CN 200910074065A CN 101507432 B CN101507432 B CN 101507432B
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Abstract
The invention relates to a carvacrol microemulsion and a production process thereof, and relates to the technical field of carvacrol microemulsion pesticide. The carvacrol microemulsion comprises the following compositions in portion by weight: 2.0 to 6.0 portions of carvacrol, 43 to 70 portions of pyroligneous liquid (or water), 8.0 to 20 portions of emulsifier and 20 to 31 portions of solvent, and is prepared by mixing, stirring and emulsifying. The carvacrol microemulsion has the advantages that the carvacrol microemulsion has strong stability, good sterilizing effect, good control efficiency, environmental protection and safety, wide range of application, low cost, and high economic benefit and social benefit, and can increase the prophylactic variety; and the production process is simple, unique and pollution-free, and has low cost.
Description
Technical field
The present invention relates to the carvacrol micro-emulsion technical field of pesticide.
Background technology
Carvacrol is the wild marjoram main body of oil, and origanum oil is the extract of wild marjoram grass, also can carry out synthetic.Carvacrol is water insoluble, but is dissolved in organic solvents such as ether, ethanol, and carvacrol has special fragrance smell and very strong antibiotic property, is widely used in industries such as spices, food and feed additive and bactericide.
At present; The composite dose of product that carvacrol is used to bactericide mainly contains 2 kinds: a kind of is 5% fungi water purification agent (certain insecticide factory produce), and it is by 2.5% carvacrol and 2.5% composite the forming of acrylic acid, owing to being that its less stable of aqua, top layer are separated out grease easily and reduced result of use; Acrylic acid is a kind of industrial raw material; Have strong corrosivity and excitant, cause certain pollution, and acrylic acid cost higher (be pyroligneous liquor about 3 times), increased application cost.Another kind of composite dose is 2.1% fourth carvacrol aqua (being produced by certain biochemistry corporation,Ltd.); It is the complex preparation by 0.3% fourth carvacrol and 1.8% carvacrol, though fungicidal spectrum is wide, production cost is high; And owing to be its poor stability of aqua, result of use is understable.
Summary of the invention
The purpose of this invention is to provide carvacrol micro-emulsion and production technology thereof, carvacrol micro-emulsion stability of the present invention is strong, and bactericidal effect is good, can increase the kind of diseases prevention, improves control efficiency; Cost is lower, and purposes is wide, has high economic benefit and social benefit; Its production technology is simple, unique, pollution-free, cost is low.
One of the present invention's main technical schemes is: carvacrol micro-emulsion is characterized in that having following components by weight percent umber proportioning: carvacrol: pyroligneous liquor (or water): emulsifier: solvent=2.0～6.0 part: 43～70 parts: 8.0～20 parts: 20～31 parts.
Described carvacrol content is the content that is converted to 100% carvacrol.
Acetic acid content 2.6 ± 0.1%, pH value 3～4 are good in the described pyroligneous liquor.
Described emulsifier is with isomery alcohol and ethylene oxide condensate---and the E-1310 emulsifier is good, also emulsifier such as available agricultural emulsifier NO.
Said solvent can be ethanol, ether of content 80%～99.9% etc., and is preferable with 95% alcohol solvent.
The methyl alcohol that has auxiliary agent 80%～99.9% in the said components by weight percent umber proportioning is good, and 80%～99.9% methyl alcohol is 0～1.5 part.
Described carvacrol micro-emulsion, it is good having following components by weight percent umber proportioning:
Carvacrol: pyroligneous liquor (or water): emulsifier: solvent: methyl alcohol=2.5～5.0 part: 50～67 parts: 9.5～16.8 parts: 21～28.2 parts: 0～1.5 part.
The present invention's two main technical schemes is: a kind of production technology according to above-mentioned various carvacrol micro-emulsions is characterized in that having following steps:
(1) calculates by proportioning and take by weighing the former medicine of carvacrol, put into container;
(2) in container, add solvent, stirring and dissolving by proportioning;
(3) add emulsifier, stirring and emulsifying by proportioning;
(4) add pyroligneous liquor (or water) by proportioning, stir;
(5) add auxiliary agent methyl alcohol by proportioning, be stirred well to soup as clear as crystal till, promptly get goods.
Good effect of the present invention is: carvacrol micro-emulsion stability of the present invention is strong, and bactericidal effect is good, can increase the kind of diseases prevention, and control efficiency is good, Environmental Safety, and cost is low, and purposes is wide, has high economic benefit and social benefit; Its production technology is simple, unique, pollution-free, cost is low.
Because microemulsion of the present invention is to be main solvent with water, not only saved a large amount of organic solvents, and alleviated pollution environment, help the sustainable development of agricultural.In the pesticides new formulation of water baseization, so microemulsion of the present invention has following significant advantage:
1, grain drips trickle (10-100 nanometer), promotes that to crop and insect strong adhesion, penetration power is big to the animal vegetable tissue internal penetration.
2, good stability, microemulsion belong to stabilising system on the thermodynamics, can place for a long time not take place to be separated, but and arbitrary proportion dilution in use.
3, Environmental Safety, microemulsion for organic solvent, have suppressed the volatilization of agricultural chemicals steam with water.The while microemulsion does not fire not quick-fried, is convenient to safety in production storing and use.
4, pyroligneous liquor is a by product of producing charcoal, is the condensing and recycling liquid of charcoal kiln smog, contains more than 200 kind of active principles such as jealous woman acid, another name for, ethanol; Be that a kind of new bio organic plant nutrition is fertile; Be again a kind of natural organic killing pests and suppressing bacteria agent, have sterilization, control worm, disease-resistant, promote effect such as plant growth, can be used as green nuisance free pesticide, little fertile use; Improve crop yield and quality; Mix use with chemical pesticide, chemical fertilizer, can improve the usefulness of agricultural chemicals, chemical fertilizer, and the ability degrading pesticide residues; Pyroligneous liquor is used for the rice field can prevent and treat rice seedling blight, is used to prevent and treat the apple canker effect and is superior to medicine commonly used " disease must clearly ", and the control watermelon blight is superior to using medicine " methyl Tobe rule " always, prevents that the cucumber downy mildew effect is higher than " aliette ".Expand the development and utilization measure of pyroligneous liquor, can promote charcoal manufacturer to reclaim pyroligneous liquor, promptly increase income, also reduce the smog emission amount, help environmental protection.Because the pyroligneous liquor raw material sources are wide; Cheap and have sterilization, disease-resistant, promote effect such as plant growth; And the ability degrading pesticide residues, and pyroligneous liquor is with low cost, therefore; Utilize the composite carvacrol pyroligneous liquor microemulsion of processing of pyroligneous liquor and carvacrol, realized the effectiveness stack of 2 kinds of natural plants source pesticides.
Be described further below in conjunction with instance, but not as to qualification of the present invention.
Embodiment
1, FORMULATION EXAMPLE components by weight percent proportioning of the present invention is seen table 1.
Table 1
Two, above-mentioned preparation production technique embodiment:
1, capital equipment instrument:
1 of can filler, 1 in agitator, 1,150 liters round plastic containers of 1,5 kilograms electronic balances of double centner platform balance are some;
2, preparation technology (by proportioning, method is with above-mentioned, slightly).
Below only illustrate with 100 kilograms of medicament preparation technologies of the present invention of 2.5% content:
(1) take by weighing 2.78 kilogram of 90% former medicine of carvacrol, putting into volume is the hydrostatic column more than 150 liters;
(2) add 21 kilogram of 95% alcohol solvent, stir dissolving in 2 minutes;
(3) add 9.5 kilogram of 1310 emulsifier, stir emulsification in 3 minutes;
(4) add 67 kilograms of pyroligneous liquors, and fully stir more than 5 minutes;
(5) add 1.0 kilograms of auxiliary agent 95% methyl alcohol, stir more than 5 minutes to soup as clear as crystal till;
(6) bottling;
(7) pack.
Three, effect: botanical pesticide 2.5% carvacrol pyroligneous liquor microemulsion drug effect contrast of the present invention
With medicament 2.5% carvacrol pyroligneous liquor microemulsion of the present invention, carry out indoor antibacterial test and field control effectiveness test respectively with clear water and 5% fungi clean (certain insecticide factory provides), working concentration is 500 times of liquid, drug effect contrasts as follows:
(1) to the control efficiency of fruit white rot of grape
Indoor antibacterial result: 2.5% carvacrol pyroligneous liquor 95.46%, fungi clean 87.58%.
Field control effect: 2.5% carvacrol pyroligneous liquor 86.8%, fungi clean 74.4%.
(2) to the control efficiency of downy mildew of garpe
Indoor antibacterial result: 2.5% carvacrol pyroligneous liquor 93.16%, fungi clean 88.14%.
Field control effect: 2.5% carvacrol pyroligneous liquor 89.3%, fungi clean 81.4%.
(3) to the control efficiency of ring rot of apple
Indoor antibacterial result: 2.5% carvacrol pyroligneous liquor 98.22%, fungi clean 90.66%.
Field control effect: 2.5% carvacrol pyroligneous liquor 91.71%, fungi clean 86.8%.
Result of the test shows: the bactericidal and bacteriostatic effect of 2.5% carvacrol pyroligneous liquor microemulsion obviously is better than 5% fungi water purification agent; Because pyroligneous liquor is with low cost only to have acrylic acid about 30%; Reduced the production cost and the producer's drug cost so significantly; Simultaneously, reduced pollution again, had the stronger market competitiveness and the space of bigger production application environment.
Testing result through certain authoritative inspection center shows: 2.5% carvacrol pyroligneous liquor microemulsion is little poison (LD to chmice acute per os toxicity
50＞5000mg/kg), in the classification of toxicity of pesticide the minimum rank of toxicity, can, use organic food in producing.
Claims (2)
1. carvacrol micro-emulsion is characterized in that having following components by weight percent umber proportioning:
Carvacrol: pyroligneous liquor: isomery alcohol and ethylene oxide condensate emulsifier E-1310: 80%～99.9% ethanol: 95% methyl alcohol=2.5～5.0 part: 50～67 parts: 9.5～16.8 parts: 21～28.2 parts: 1～1.5 part; Acetic acid content in the above-mentioned pyroligneous liquor is 2.6 ± 0.1%, the pH value is 3～4, and above-mentioned carvacrol is the content that is converted to 100% carvacrol, promptly in pure carvacrol.
2. the production technology of a carvacrol micro-emulsion according to claim 1 is characterized in that having following steps:
(1) calculates by proportioning and take by weighing the former medicine of carvacrol, put into container;
(2) in container, add 80%～99.9% alcohol solvent, stirring and dissolving by proportioning;
(3) add isomery alcohol and ethylene oxide condensate emulsifier E-1310, stirring and emulsifying by proportioning;
(4) add pyroligneous liquor by proportioning, fully stir;
(5) add 95% methyl alcohol by proportioning, be stirred well to soup as clear as crystal till, promptly get goods.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910074065 CN101507432B (en) | 2009-04-02 | 2009-04-02 | Carvacrol micro-emulsion and production technique thereof |
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| CN 200910074065 CN101507432B (en) | 2009-04-02 | 2009-04-02 | Carvacrol micro-emulsion and production technique thereof |
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| CN101507432A CN101507432A (en) | 2009-08-19 |
| CN101507432B true CN101507432B (en) | 2012-12-19 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102972398A (en) * | 2012-12-22 | 2013-03-20 | 云南农业大学 | Application of compound to prevention and treatment of plant fungal diseases caused by alternaria alternata |
| CN102972399A (en) * | 2012-12-22 | 2013-03-20 | 云南农业大学 | Application of compound to prevention and treatment of plant fungal disease caused by fusarium |
| CN102972397A (en) * | 2012-12-22 | 2013-03-20 | 云南农业大学 | Application of compound to prevention and treatment of rice blast |
| CN103999851A (en) * | 2013-02-24 | 2014-08-27 | 陈浩 | Carvacrol emulsion in water and preparation method tehreof |
| CN104604939A (en) * | 2015-01-08 | 2015-05-13 | 馥稷生物科技发展（上海）有限公司 | Pesticide composite containing sophocarpidine |
| MX2017010497A (en) * | 2015-02-16 | 2018-04-24 | Laboratoire M2 | Aqueous compositions for controlling pests or regulating plant growth, said compositions comprising thymol or carvacrol, a surfactant, and a solvent. |
| CN104642326B (en) * | 2015-02-16 | 2016-02-10 | 河南科技学院 | A kind ofly contain bactericidal composition of penta benzene pyrrole bacterium amine and carvacrol and uses thereof |
| CN108124862B (en) * | 2017-12-21 | 2020-11-17 | 江西省农业科学院植物保护研究所 | Synergistic auxiliary agent of pesticide for killing borers and use method thereof |
| CN110226598A (en) * | 2019-07-10 | 2019-09-13 | 福鼎市匠心百年茶业有限公司 | A kind of tea tree pest repellant of Extracts from Plant Recourses |
| CN117581868A (en) * | 2023-11-24 | 2024-02-23 | 湖南农业大学 | Bactericide for preventing and treating kiwi fruit canker and citrus canker and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051563A1 (en) * | 1999-03-04 | 2000-09-08 | Sanofi-Synthelabo | Pharmaceutical compositions for oral administration comprising a benzamide and at least an absorption promoter |
| CN1350435A (en) * | 1999-05-12 | 2002-05-22 | 阿克佐诺贝尔公司 | A composition containing carvacrol and thymol for use as abactericide |
| CN1520258A (en) * | 2001-04-17 | 2004-08-11 | ������������ʽ���� | Bactericide compsn. |
| CN1592578A (en) * | 2001-10-04 | 2005-03-09 | 以色列国家农业部富卡尼中心 | Microbiocidal formulation comprising essential oils or their derivatives |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051563A1 (en) * | 1999-03-04 | 2000-09-08 | Sanofi-Synthelabo | Pharmaceutical compositions for oral administration comprising a benzamide and at least an absorption promoter |
| CN1350435A (en) * | 1999-05-12 | 2002-05-22 | 阿克佐诺贝尔公司 | A composition containing carvacrol and thymol for use as abactericide |
| CN1520258A (en) * | 2001-04-17 | 2004-08-11 | ������������ʽ���� | Bactericide compsn. |
| CN1592578A (en) * | 2001-10-04 | 2005-03-09 | 以色列国家农业部富卡尼中心 | Microbiocidal formulation comprising essential oils or their derivatives |
Non-Patent Citations (1)
| Title |
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| 说明书第2页第10行至第4页第14行. |
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