CN101489593B - 通过脂质体酶的治疗剂肿瘤特异性递送 - Google Patents

通过脂质体酶的治疗剂肿瘤特异性递送 Download PDF

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CN101489593B
CN101489593B CN200780027001.3A CN200780027001A CN101489593B CN 101489593 B CN101489593 B CN 101489593B CN 200780027001 A CN200780027001 A CN 200780027001A CN 101489593 B CN101489593 B CN 101489593B
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tumor
doxorubicin
drug
agent
tumors
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CN101489593A (zh
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I·郑
S·周
K·W·金泽勒
B·沃戈尔斯腾
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Johns Hopkins University
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
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  • Oncology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CN200780027001.3A 2006-06-19 2007-06-19 通过脂质体酶的治疗剂肿瘤特异性递送 Active CN101489593B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81454606P 2006-06-19 2006-06-19
US60/814,546 2006-06-19
PCT/US2007/014274 WO2007149433A2 (en) 2006-06-19 2007-06-19 Tumor-specific delivery of therapeutic agents via liposomase

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CN101489593A CN101489593A (zh) 2009-07-22
CN101489593B true CN101489593B (zh) 2015-11-25

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US (4) US8444963B2 (enExample)
JP (1) JP5319523B2 (enExample)
KR (1) KR101376634B1 (enExample)
CN (1) CN101489593B (enExample)
WO (1) WO2007149433A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210589B1 (en) * 2009-01-22 2015-05-06 Ludwig-Maximilians-Universität München Vesicular phospholipid gels comprising proteinaceous substances
US20130323167A1 (en) * 2010-10-21 2013-12-05 The Johns Hopkins University Detecting and treating solid tumors through selective disruption of tumor vasculature
US20150191706A1 (en) 2012-07-13 2015-07-09 Teiko Heisei University Antitumour agent, marker for tumour detection, and oral vaccine agent
EP3265059A4 (en) 2015-03-03 2018-08-29 Cureport Inc. Combination liposomal pharmaceutical formulations
CN107530291A (zh) 2015-03-03 2018-01-02 奎尔波特股份有限公司 双重负载的脂质体药物制剂
CN108136031B (zh) * 2015-10-07 2022-02-18 盐水港精糖株式会社 包含紫杉烷化合物的脂质体
CN115244069A (zh) 2019-12-18 2022-10-25 埃克斯欧姆尼斯生物技术有限公司 遗传修饰的梭状杆菌菌株及其用途
TW202345881A (zh) * 2022-03-23 2023-12-01 國立研究開發法人理化學研究所 用以治療惡性腫瘤的組合醫藥

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WO2006007372A2 (en) * 2004-06-16 2006-01-19 Ostroff Gary R Drug delivery product and methods

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FI20031528A0 (fi) * 2003-10-17 2003-10-17 Ctt Cancer Targeting Tech Oy Terapeuttinen liposomikoostumus ja menetelmä sen valmistamiseksi
JP2005298486A (ja) 2004-03-15 2005-10-27 Nipro Corp リポソームを含む癌治療用医薬組成物
MX2007004744A (es) 2004-10-26 2007-10-23 Pharma Mar Sa Doxorubicina lipos??mica pegilada en combinacion con ecteinascidina 743.

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Publication number Priority date Publication date Assignee Title
WO2006007372A2 (en) * 2004-06-16 2006-01-19 Ostroff Gary R Drug delivery product and methods

Non-Patent Citations (2)

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Lieve Van Mellaert等.Clostridium spores as anti-tumour agents.《TRENDS in Microbiology》.2006,第14卷(第4期),全文. *

Also Published As

Publication number Publication date
CN101489593A (zh) 2009-07-22
US8444963B2 (en) 2013-05-21
JP2009541319A (ja) 2009-11-26
JP5319523B2 (ja) 2013-10-16
US20110250258A1 (en) 2011-10-13
KR101376634B1 (ko) 2014-03-27
US8901100B2 (en) 2014-12-02
US8568708B2 (en) 2013-10-29
US20150306184A1 (en) 2015-10-29
WO2007149433A2 (en) 2007-12-27
KR20090027674A (ko) 2009-03-17
US20130142862A1 (en) 2013-06-06
WO2007149433A3 (en) 2008-11-06
US20130315986A1 (en) 2013-11-28

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