CN101485756A - Chinese medicament preparation for treating mammary gland fibroid tumor and preparation method thereof - Google Patents
Chinese medicament preparation for treating mammary gland fibroid tumor and preparation method thereof Download PDFInfo
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- CN101485756A CN101485756A CNA2009100211957A CN200910021195A CN101485756A CN 101485756 A CN101485756 A CN 101485756A CN A2009100211957 A CNA2009100211957 A CN A2009100211957A CN 200910021195 A CN200910021195 A CN 200910021195A CN 101485756 A CN101485756 A CN 101485756A
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Abstract
The invention discloses a novel Chinese traditional medicine preparation for treating hyperplasia of mammary glands and a method for preparing the same, which belongs to the technical field of Chinese traditional medicine preparations. The Chinese traditional medicine preparation is extracted from the following natural Chinese herbal medicines in portion by weight: 10 to 20 portions of radix bupleuri, 12 to 24 portions of radix paeoniae alba, 10 to 20 portions of rhizoma atractylodis macrocephalae, 12 to 24 portions of chinese angelica, 12 to 24 portions of tuckahoe, 12 to 24 portions of gardenia, 5 to 10 portions of mint, 10 to 20 portions of liquorice, and the like, wherein the materials are prepared into capsules, granules or tablets according to the prior preparation process. Clinical studies prove that the novel Chinese traditional medicine preparation has the efficacies of soothing liver and qi stagnation, softening hardness to dissipate stagnation, and regulating vital energy and invigorating blood circulation, can be applied to treating diseases of hyperplasia of mammary glands, fibroadenoma of breast, and the like, has certain effect of improving the mood of a sufferer, increasing the appetite and improving sleeping, and has no obvious untoward effects and good safety; besides, the adoption of the novel Chinese traditional medicine preparation can lighten the economic burden of sufferers.
Description
Affiliated technical field
The invention belongs to a kind of medicine for the treatment of mammary gland fibroma, specifically a kind of a kind of new Chinese medicine preparation of making by weight extraction by each raw material of Chinese medicine.
Background technology
Mammary gland fibroma is to betide the epithelioglandular Combination tumor of fibrous tissue in the lobules of mammary gland, be modal a kind of in the breast benign tumor, tumor is sent out the year women in 18-35 well, especially the most common with 20-25 year women, it is generally acknowledged that the mammary gland fibroma person of cancerating is more rare, can be divided into three types clinically: the plain edition fibroadenoma, this kind of is seen at most, the tumor body is little, and poor growth is generally below 3cm; The hebephrenictype fibroadenoma occurs in the menarche phase mostly, and is clinical more rare, and characteristics are very fast for growth, and the tumor body is bigger, and the course of disease can take the full milk room about about 1 year, and the lump maximum diameter is 1-13cm; The giant fibres adenoma: middle-aged women sees more, is found in women before and after gestation, suckling, the amenorrhea, and characteristics are to grow greatlyyer, and it is above or bigger to reach 10cm, and idol can have sarcomatous change.The formation and the ovarian function of primary disease are vigorous, and body is relevant to the sensitivity of estrogen overstimulation with the breast local organization, and estrogen level is too high, and mammary gland tissue to it local response takes place, thereby causes primary disease.Lump often the initial stage less, poor growth, size is generally 1-3cm, does not have any manifest symptom usually, no pain or tenderness can have slight tenderness, occasionally often in stumbling on mostly, mostly touched when having a bath, single-shot or pilosity, tumor presents circle or ellipse, also can be nodositas, lobulated, smooth surface, matter is real tough, and clear border does not have adhesion with surrounding tissue, touched the sense of sliding, surface skin does not have change, and axillary gland does not have enlargement.
Mammary gland fibroma is one of common disease of women, it also is a kind of frequently-occurring disease, be mainly in 25 years old～50 years old women, developed country's women's sickness rate is about 1/5th, and China also has 23.4%～38.9% women to suffer from this disease, and because modern women exists not suckling in puerperal or the too short phenomenon of time of nursing, suppressed galactopoiesis, cause the endocrine disturbance, thereby caused cyclomastopathy, cause this disease sickness rate that the trend of rejuvenation is arranged.
At present the main method of treatment mammary gland fibroma is: 1. operative treatment: the method for employing is an excision, its advantage is fast with fine tumor excision, shortcoming is that relapse rate is high, and near 100%, it is effective that this kind therapeutic scheme is fit to bigger one fine tumor and menopausal women now; 2. western medicine or Chinese medicine add western medicine: this kind method is a kind of hormonotherapy, quick result, but drug withdrawal promptly sends out, and is fit to preoperative swollen thing and dwindles, and is convenient to operation, and be applicable to the swollen faster thing of growth; 3. treatment by Chinese herbs: shortcoming is that dispersing tumor speed is slower than operation and western medicine, and advantage is that side effect is little, and the anti-recurrence rate is effective, can stablize state of an illness indiffusion, not shift, and removal effect is better relatively, and the patient who receives treatment at present is satisfied.
Although operation is the most effective Therapeutic Method of mammary gland fibroadenoma, and do not mean that, but should strictly grasp operation opportunity and operative indication, cannot treat different things as the same as long as need immediate surgery once the discovery adenoma.As about 20 years old unmarried women, if adenoma is little, then unsuitable immediate surgery should can be given traditional Chinese medical herbal treatment in case of necessity based on clinical observation; If be married young women, its adenoma more than 1cm, then should be before gestation the hands art; If in emerging adenoma gestation age of sucking, then at first observe its lump growing state,, answer immediate surgery for the lump rapid person that grows; If be that women more than 35 years old finds adenoma, particularly adenoma has newly appearred in the later women of menopause, then answers the immediate surgery excision, and does frozen section examination in the art; The case that recurs again in the original place for postoperative should be watched out for it and cancerate, and every recurrence has once just increased some probabilities that cancerate again, so, must perform the operation in principle, and when operation, need expansion slightly to excise some bodies of gland on every side, the postoperative treatment that can take traditional Chinese medicine reduces the probability that it cancerates.
Mammary gland fibroma and cyclomastopathy belong to the traditional Chinese medical science " nodules of the breast ", " nodule in the breast ", " newborn painful abdominal mass " category together.According to the internal organs theory of channels and collaterals, dash wantonly two arteries and veins, on can moisten foster breast, the warm uterus of energy simultaneously.So cyclomastopathy, breast caking both can appear in the insufficiency of kidney-YANG Chong and Ren channel disorder, through the symptom of preceding distending pain, can show menoxenia again." Waike Zhengzong, Orthodox Manual of External Diseases " meaning: " nodules of the breast is a nodule in the breast, shape such as ball ovum, or heavily weigh down and have a pain or not bitterly, color of the leather is constant, it is examined with the susceptible to anger growth and decline, or worry impairing spleen, and pent-up forms "." the true select of surgery " meaning: " nodules of the breast, tuberculosis of breast is hard, and it is big as money to begin, and gradually big as the peach ovum, color of the leather is as usual.Meet cold then pain, this is by the cold physique cold drink, and in addition institute's stagnated phlegm drink flows into the stomach network, gather do not loose due to, young and impetuous, suffers from and can dissipate in one, two year,, should temperance for food and drink, suffer from angryly, exempt from the change of breast carcinoma if old weakness of QI suffers from and not controlling through several years persons ".Clinically, the method for treatment medication also can be taked the square medicine for the treatment of different diseases with the same therapeutic principle, adopts the rule of treatment of dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving and Chong and Ren Meridians regulating more.
Summary of the invention
It is definite to the purpose of this invention is to provide a kind of clinical efficacy, and toxic and side effects is little, the medicine of the cheap and treatment mammary gland fibroma that has wide range of applications.
The objective of the invention is to be achieved through the following technical solutions: the medicine of treatment mammary gland fibroma, its active component is made up of following component by weight ratio: 10-20 parts of Radix Bupleuri, 12-24 parts of the Radix Paeoniae Albas, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 12-24 parts of Radix Angelicae Sinensis, 12-24 parts in Poria, 12-24 parts of Fructus Gardeniaes, 5-10 parts of Herba Menthaes, 10-20 parts in Radix Glycyrrhizae.
The medicine of treatment mammary gland fibroma of the present invention can adopt the conventional formulation method of Chinese medicine preparation to be prepared into suitable clinical preparation, for example can be tablet, capsule and electuary etc., first-selected capsule.
The pharmaceutical preparation of treatment mammary gland fibroma, its step is as follows:
1) takes by weighing each raw material by following weight ratio: 15 parts of Radix Bupleuri, 20 parts of the Radix Paeoniae Albas, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Angelicae Sinensis, 20 parts in Poria, 20 parts of Fructus Gardeniaes, 10 parts of Herba Menthaes, 15 parts in Radix Glycyrrhizae;
2) the above-mentioned medical material decocting that adds 10 times of amounts boils 3 times, and each 1-1.5 hour, filter, collecting decoction is concentrated into the extractum that relative density is 1.20-1.25, drying;
3) add ethanol and make and contain alcohol amount and reach 60%-75%, placement is spent the night, filter, the supernatant decompression recycling ethanol, be concentrated into an amount of, drying;
4) exsiccant extract powder is broken into fine powder, granulates, and is prepared into tablet, granule, capsule etc., preferably capsule according to the preparation process of routine.
Specific embodiments
The realization of purpose of the present invention is based in the summary of experience of modern pharmacology research and clinical case, and in conjunction with motherland's medical science to mammary gland fibroma understanding and Therapeutic Principle: will treat the medicine of mammary gland fibroma, consist of by the optimized weight ratio of following various raw materials: 15 parts of Radix Bupleuri, 20 parts of the Radix Paeoniae Albas, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Angelicae Sinensis, 20 parts in Poria, 20 parts of Fructus Gardeniaes, 10 parts of Herba Menthaes, 15 parts in Radix Glycyrrhizae.
This preparation of compositions method is: the decocting that above a few flavor medical materials add 10 times of amounts boils 3 times, each 1-1.5 hour; Filter, collecting decoction is concentrated into the extractum that relative density is 1.20-1.25, adding ethanol makes the alcohol amount of containing reach 60%-75%, placement is spent the night, and filters the supernatant decompression recycling ethanol, be concentrated into an amount of, drying, dried cream powder is broken into fine powder, granulates, preparation process according to routine is prepared into tablet, granule, capsule etc., preferably capsule.
The dosage of medicine of the present invention is relevant with dosage form, patient age and health status, for referencial usely with capsule is: oral, one time 3～4,3 times on the one, take half an hour after meal, 3 months is a course of treatment.
Among the we, the Radix Bupleuri hardship is slightly cold, and returns liver, gallbladder meridian, has reconciling superficies and interior, and effects such as soothing the liver yang invigorating are used for cold, fever, alternate attack of chill and fever, and depression of liver-QI, distending pain in the chest and hypochondrium etc. are so Radix Bupleuri is monarch drug in the side.Liver, spleen channel are gone in Radix Paeoniae Alba nature and flavor picric acid, cold, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, and yin fluid astringing is received the antiperspirant effect, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia; Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature is returned spleen, stomach warp, invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive, be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement; More than two the flavor medicines be ministerial drug.The Radix Angelicae Sinensis nature and flavor are sweet, hot, and temperature is returned liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores, rheumatic arthralgia, injury from falling down; Poria is sweet, light, and flat, GUIXIN, lung, spleen, kidney channel have promoting diuresis to eliminate damp pathogen, and the spleen invigorating mind calming is used for the edema oliguria, the phlegm retention vertigo and palpitation, and insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, effects such as palpitation with fear insomnia; Fructus Gardeniae nature and flavor hardship, cold, GUIXIN, lung, tri-jiao channel, but pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, it is vexed to be used for calentura, the jaundice dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain; More than three the flavor, merit is at adjuvant drug.Herba Menthae nature and flavor suffering, lung, Liver Channel are gone in cold, dispelling wind, the heat radiation, ward off dirty, the detoxifcation, can control affection due to external wind and heat, the headache, conjunctival congestion, laryngopharynx swelling and pain, the dyspepsia flatulence, aphtha, the toothache, skin ulcer scabies, urticaria; Radix Glycyrrhizae property is flat, and sweet in the mouth returns 12 through invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, more than two flavor medicines, merit is at messenger drug.
The specific embodiment:
With clinical is the effect that example illustrates treatment mammary gland fibroma of the present invention:
Present embodiment is a most preferred embodiment of the present invention, and the medicine of treatment mammary gland fibroadenoma is the example explanation with the optimal formulation capsule.
1, clinical data:
Among the 108 routine patients, the oldest person 42 years old, age reckling 16 years old, 29 years old mean age, the elder of the course of disease 5 years, the shortest person 6 months.All cases are all from the out-patient of the court, private prosecution self check or find that breast mass examines when having a medical check-up unintentionally.Check and find: patient's one side breast touches lump, mostly is single-shot, and goes up quadrant outward for seeing the normal rounded or oval of lump with breast more, not of uniform size, quality is hard, smooth surface, and boundary is clear, mobility is big, not with the surrounding tissue adhesion, and no pain and tenderness.Poor growth can not suppurated and be festered, and is irrelevant with menstrual cycle.Molybdenum target X line is taken the photograph sheet and other image checks, is shown as the reality enclosed mass, to older, carry out the lump pin after the explanation and inhales cytolgical examination and get rid of pernicious lump.All case is examined and is mammary gland fibroma.
2, Therapeutic Method:
Capsule of the present invention, oral 3 times of every day, one time 3～4, take half an hour after meal, or abide by testament, 3 months is a course of treatment.
3, the evaluation criteria of mammary gland fibroadenoma therapeutic effect is:
Cure: the lump complete obiteration;
Take a turn for the better: lump dwindles;
Invalid: lump does not have change or becomes big.
4, therapeutic outcome:
Among the 108 routine mammary gland fibroma patients through observing,, cure 68 examples through the treatment of a course of treatment, 35 examples that take a turn for the better, invalid 5 examples, cure rate is 63.0%, total effective rate is 95.4%.
In therapeutic process of the present invention, malaise symptoms such as allergy, diarrhoea, weak, poor appetite appear in no case.
Claims (5)
1, a kind of medicine for the treatment of mammary gland fibroma is characterized in that it is made up of following bulk drugs: 10-20 parts of Radix Bupleuri, 12-24 parts of the Radix Paeoniae Albas, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 12-24 parts of Radix Angelicae Sinensis, 12-24 parts in Poria, 12-24 parts of Fructus Gardeniaes, 5-10 parts of Herba Menthaes, 10-20 parts in Radix Glycyrrhizae.
2, the medicine of treatment mammary gland fibroma as claimed in claim 1 is characterized in that the weight portion of the optimum of each crude drug is: 15 parts of Radix Bupleuri, 20 parts of the Radix Paeoniae Albas, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Angelicae Sinensis, 20 parts in Poria, 20 parts of Fructus Gardeniaes, 10 parts of Herba Menthaes, 15 parts in Radix Glycyrrhizae.
3, the process for preparing medicine of treatment mammary gland fibroma as claimed in claim 2 is characterized in that and can be prepared into capsule, granule or tablet by preparation process routinely.
4, the process for preparing medicine of treatment mammary gland fibroma according to claim 2, it is characterized in that the preparation method of capsule or granule is: the decocting that above several flavors add 10 times of amounts boils 3 times, each 1 hour; Filter, collecting decoction is concentrated into the extractum that relative density is 1.20-1.25, adds ethanol and makes and contain the alcohol amount and reach 70%, and placement is spent the night, filter, the supernatant decompression recycling ethanol, be concentrated into an amount of, drying, mixing is granulated, granulate, packing promptly gets capsule or granule.
5, the process for preparing medicine of treatment mammary gland fibroma according to claim 2, it is characterized in that the preparation method of tablet is: the decocting that above several flavors add 10 times of amounts boils 3 times, each 1 hour; Filter, collecting decoction is concentrated into the extractum that relative density is 1.20-1.25, add ethanol and make and contain alcohol amount and reach 70%, placement is spent the night, and filters, the supernatant decompression recycling ethanol, be concentrated in right amount, drying, dried cream powder is broken into fine powder, add microcrystalline Cellulose, carboxymethyl starch and magnesium stearate adjuvant, mixing, the system granule is pressed into tablet.
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| CN2009100211957A CN101485756B (en) | 2009-02-19 | 2009-02-19 | Chinese medicament preparation for treating mammary gland fibroid tumor and preparation method thereof |
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| CN2009100211957A CN101485756B (en) | 2009-02-19 | 2009-02-19 | Chinese medicament preparation for treating mammary gland fibroid tumor and preparation method thereof |
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| CN101485756B CN101485756B (en) | 2011-06-15 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398975A (en) * | 2014-11-13 | 2015-03-11 | 高宏 | Traditional Chinese medicinal preparation for treating fibroadenoma of breast and preparation method thereof |
| CN105749174A (en) * | 2016-04-23 | 2016-07-13 | 包晓娜 | Traditional Chinese medicine composition for treating fibroadenoma of breasts |
| CN107320571A (en) * | 2017-07-23 | 2017-11-07 | 邢介云 | It is a kind of to treat pharmaceutical composition of mammary gland fibroma and preparation method thereof |
| CN107362281A (en) * | 2017-06-30 | 2017-11-21 | 禹州市合同泰药业有限公司 | A kind of prepared slices of Chinese crude drugs formula for treating mammary gland fibroma and preparation method thereof |
| CN108853455A (en) * | 2018-08-24 | 2018-11-23 | 王政和 | A kind of Chinese medicine composition for breast cancer and the proliferation of mammary gland |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186083C (en) * | 2003-04-07 | 2005-01-26 | 杨秀云 | Chinese medicine for treating mammary gland foliole proliferation |
| CN100496467C (en) * | 2004-09-29 | 2009-06-10 | 天津药物研究院 | Soft capsule containing extract of tree peony bar and cape jasmine and its preparation method |
| CN100528220C (en) * | 2006-07-20 | 2009-08-19 | 四川泰华堂制药有限公司 | Gynecological Chinese patented medicine for relieving depressed liver and clearing heat, strengthening spleen and nourishing blood and its preparing method |
-
2009
- 2009-02-19 CN CN2009100211957A patent/CN101485756B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398975A (en) * | 2014-11-13 | 2015-03-11 | 高宏 | Traditional Chinese medicinal preparation for treating fibroadenoma of breast and preparation method thereof |
| CN105749174A (en) * | 2016-04-23 | 2016-07-13 | 包晓娜 | Traditional Chinese medicine composition for treating fibroadenoma of breasts |
| CN107362281A (en) * | 2017-06-30 | 2017-11-21 | 禹州市合同泰药业有限公司 | A kind of prepared slices of Chinese crude drugs formula for treating mammary gland fibroma and preparation method thereof |
| CN107320571A (en) * | 2017-07-23 | 2017-11-07 | 邢介云 | It is a kind of to treat pharmaceutical composition of mammary gland fibroma and preparation method thereof |
| CN108853455A (en) * | 2018-08-24 | 2018-11-23 | 王政和 | A kind of Chinese medicine composition for breast cancer and the proliferation of mammary gland |
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| CN101485756B (en) | 2011-06-15 |
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