CN101474217B - Antiphlogistic analgesic Capparis spinosa L. catablasm and preparation method thereof - Google Patents
Antiphlogistic analgesic Capparis spinosa L. catablasm and preparation method thereof Download PDFInfo
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- CN101474217B CN101474217B CN 200910113221 CN200910113221A CN101474217B CN 101474217 B CN101474217 B CN 101474217B CN 200910113221 CN200910113221 CN 200910113221 CN 200910113221 A CN200910113221 A CN 200910113221A CN 101474217 B CN101474217 B CN 101474217B
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Abstract
The invention discloses an anti-inflammation-analgesia capparis spinosa cataplasm and a preparation method thereof. The invention can be taken off and stuck on at any time, improving the adaptability of a patient. The drug is a capparis extract, the stroma is prepared, according to a certain mixture ratio, by water-soluble polymer skeletal materials, cementing compound, filling agent, cross-linking agent, pH regulator, humectant, preservative, transdermal enhancer, and the like, which have different mixture ratios. The invention has the advantages that the anti-inflammation-analgesia therapeutic effectiveness is obvious, the drug-loading rate of the stroma is large, the transdermal absorption effect is good, the use is convenient, the sticking is comfortable, the irritation to skin is small, and the compliance of patients is high.
Description
Technical field
The present invention relates to a kind of mallet fruit rattan cataplasma with anti-inflammatory and analgesic effect and preparation method thereof.
Background technology
Mallet fruit rattan is the fruit of Capparidaceae Chinese lime platymiscium Cortex Capparis Spinosae Radicis, and distribution is extensively arranged within the border in Xinjiang, is a kind of national medicine commonly used and good sand-fixation plant in the locality.Be reported in the earliest " Chinese Herbal Medicine in Xinjiang ".In Uygur's medical science, it is warm in nature, tool dispels the wind, the effect of cold expelling, dehumidifying, detumescence, pain relieving, be used for the treatment of the diseases such as anemofrigid-damp arthralgia, the cold pain of taste edema, among the people one straight through the treatment of external application affected part for rheumatoid arthritis that it is mashed, and long Uygur nationality applicating history among the people is arranged.In Saudi Arabia, mallet fruit rattan also is the treatment rheumatism, arthritic conventional medicament.But because the backwardness of administering mode makes mallet fruit rattan cause stronger zest in patient's external application place, limited its extensive use.Thereby according to application method among the people, in conjunction with the rule of curing the disease of the traditional Chinese medical science " inner disease outer treat ", take preparation capable of permeating skin as route of administration, the exploitation antiphlogistic analgesic Capparis spinosa L. catablasm is to increase the effective way that its curative effect reduces its toxicity.The Chinese patent notification number is that CN11234375 discloses a kind of process patent that extracts arthritis effective site from plant mallet fruit rattan, but, the deficiency of the method is not for mallet fruit rattan provides a kind of administering mode that can effectively bring into play its anti-inflammatory and analgesic effect, also is not made into this modern exterior-applied formulation of cataplasma simultaneously.
Summary of the invention
The object of the present invention is to provide a kind of mallet fruit rattan cataplasma with anti-inflammatory and analgesic effect and preparation method thereof.
The object of the present invention is achieved like this:
Mallet fruit rattan cataplasma is comprised of mallet fruit rattan anti-inflammatory and antalgic activity composition and cataplasma adjuvant.
The anti-inflammatory and antalgic activity composition is mallet fruit rattan ethanol extraction in the mallet fruit rattan cataplasma, and its weight portion consists of 1～8 part.
Cataplasma adjuvant in the mallet fruit rattan cataplasma is selectively combined mutually by framework material, adhesive, wetting agent, filler, cross-linking agent, pH adjusting agent, antiseptic, transdermal enhancer.Adhesive in the cataplasma adjuvant comprises at least a of polyacrylate, sodium alginate, carbomer, sodium carboxymethylcellulose pyce, sodium carboxymethyl cellulose; Wetting agent comprises at least a of glycerol, sorbitol, propylene glycol; Cross-linking agent is the adhesive force of regulating adhesive and the substrate of cohesiveness, and cross-linking agent commonly used comprises slaine, can be at least a of aluminum chloride, aluminum sulfate, dihydroxyaluminum aminoacetate, aluminum glycinate, magnesium chloride, calcium chloride, aluminium hydroxide; PH adjusting agent can be at least a of citric acid, citric acid, tartaric acid, oleic acid; Antiseptic comprises oxybenzene first, second, propyl ester, benzoic at least a; Transdermal enhancer comprises at least a of methyl salicylate, azone, Camphora, propylene glycol, volatile oil.Framework material can comprise a kind of of gelatin, agar, alginic acid, methylcellulose, polyacrylic acid, carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, arabic gum, tragcanth; Filler also can comprise a kind of of the inorganic salts such as Kaolin and clay, Pulvis Talci, zinc oxide; Its weight portion consists of framework material≤10 part, 1～10 part of adhesive, 10～60 parts of wetting agents, filler≤5 part, cross-linking agent≤0.1～0.5 part, 0.1～0.5 part of pH adjusting agent, 0.1～0.5 part of antiseptic, 1～10 part of transdermal enhancer.
The preparation method of mallet fruit rattan cataplasma:
First mallet fruit rattan is ground into coarse powder, cross 10～40 mesh sieves, the ethanol extraction that adds 6～12 times of amounts 60%～90% refluxes 2～4 times, each 1～3 hour, filter with 100～200 mesh sieves, merge 2～4 times filtrate, again Recycled ethanol, be condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g, drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with the abundant swelling of adhesive water, get the A phase, also can A mutually in the adding filler, perhaps also can add again framework material in mutually at A, stir; Second step: antiseptic is added in the wetting agent, add again cross-linking agent and get the B phase, then the B phase is mixed mutually with A; The 3rd step: the dissolving of mallet fruit rattan ethanol extraction powder is scattered in the water, again pH adjusting agent is added in the aqueous solution of mallet fruit rattan ethanol extraction, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again transdermal enhancer behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 40-60 ℃ was dried by the fire 4～8 hours, and covered the lining protecting film, cuts, packs.
The results of pharmacodynamic test of the mallet fruit rattan cataplasma of gained of the present invention shows, mallet fruit rattan cataplasma of the present invention has the pain caused and antiinflammatory action of obvious antagonism chemistry, to film residual, skin tracing ability, comfort, skin malaise symptoms, take off that to pull pain all better, can repeatedly take off and pull and apply ointment or plaster, biocompatibility, affinity, breathability, absorption of perspiration to skin are good, and be not easy allergy, and the zest that skin is produced is little, and the production method of this mallet fruit rattan cataplasma is easy to operate.
The present invention has compared with prior art significantly reduced the directly zest of outer time spent of mallet fruit rattan, and it is obvious that mallet fruit rattan cataplasma of the present invention has anti-inflammatory pain-stopping effect simultaneously, and the skin permeability is good, simple characteristics that external application is easy to use and preparation method thereof.
The specific embodiment
Embodiment 1
Mallet fruit rattan is ground into coarse powder, crosses 10 mesh sieves, add 7 times of amount 70% ethanol extractions and reflux 2 times, each 3 hours, filter with 150 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 1 part of abundant swelling of carbomer water, get the A phase, second step: 0.1 part of ethyl hydroxybenzoate is added in 10 parts of glycerol, add again 0.1 part of aluminum sulfate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 1 part of mallet fruit rattan ethanol extraction powder dispersing and dissolving in water, is added 0.1 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added in A phase and the mixed liquor that B mixes mutually mutually, fully stir into and add again 1 part of azone behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 40 ℃ were dried by the fire 7 hours, and covered the lining protecting film, cut, pack.
Embodiment 2
Mallet fruit rattan is ground into coarse powder, crosses 20 mesh sieves, add 6 times of amount 80% ethanol extractions and reflux 3 times, each 2 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of abundant swellings of sodium carboxymethyl cellulose water, get the A phase, second step: 0.1 part of benzoic acid is added in 20 glycerol, add again 0.1 part of aluminum chloride and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 2 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.1 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 portion of Oleum menthae behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 6 hours, and covered the lining protecting film, cut, pack.
Embodiment 3
Mallet fruit rattan is ground into coarse powder, crosses 30 mesh sieves, add 8 times of amount 85% ethanol extractions and reflux 4 times, each 1 hour, filter with 200 mesh sieves, merge 4 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of abundant swellings of sodium polyacrylate water, get the A phase, second step: 0.4 part of ethyl hydroxybenzoate is added in 30 parts of propylene glycol, add again 0.3 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 5 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of tartaric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 3 parts of azones behind the colloid substance, 2 parts of propylene glycol stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 55 ℃ were dried by the fire 4 hours, and covered the lining protecting film, cut, pack.
Embodiment 4
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 9 times of amount 60% ethanol extractions and reflux 2 times, each 2 hours, filter with 200 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of abundant swellings of sodium carboxymethylcellulose pyce water, get the A phase, second step: 0.2 part of ethyl hydroxybenzoate is added in 30 sorbitol, add again 0.5 part of aluminum glycinate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 3 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of oleic acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 1 part of propylene glycol behind the colloid substance, 1 part of Camphora stirs, and namely gets really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 60 ℃ were dried by the fire 4 hours, and covered the lining protecting film, cut, pack.
Embodiment 5
Mallet fruit rattan is ground into coarse powder, crosses 20 mesh sieves, add 11 times of amount 65% ethanol extractions and reflux 3 times, each 1 hour, filter with 200 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of abundant swellings of sodium alginate water, get the A phase, second step: 0.3 part of ethyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.4 part of magnesium chloride and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 4 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of tartaric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 part of methyl salicylate behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 55 ℃ were dried by the fire 5 hours, and covered the lining protecting film, cut, pack.
Embodiment 6
Mallet fruit rattan is ground into coarse powder, crosses 30 mesh sieves, add 12 times of amount 75% ethanol extractions and reflux 3 times, each 2 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of sodium polyacrylate, 1 part of abundant swelling of gelatin water, get the A phase, second step: 0.4 part of methyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.4 part of aluminium hydroxide and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 5 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of tartaric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 1 part of azone behind the colloid substance, 5 parts of propylene glycol stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 5 hours, and covered the lining protecting film, cut, pack.
Embodiment 7
Mallet fruit rattan is ground into coarse powder, crosses 30 mesh sieves, add 12 times of amount 90% ethanol extractions and reflux 2 times, each 2 hours, filter with 200 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 5 parts of abundant swellings of sodium polyacrylate water, get the A phase, second step: 0.4 part of ethyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.1 part of calcium chloride and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 6 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 2 parts of azones behind the colloid substance, 6 parts of propylene glycol stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 45 ℃ were dried by the fire 7 hours, and covered the lining protecting film, cut, pack.
Embodiment 8
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 7 times of amount 75% ethanol extractions and reflux 3 times, each 2 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of sodium polyacrylate, 1 part of abundant swelling of kaolin, get the A phase, second step: 0.3 part of propyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.2 part of aluminium hydroxide and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 7 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 1 part of azone behind the colloid substance, 1 portion of Oleum menthae stirs, and namely gets really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 40 ℃ were dried by the fire 8 hours, and covered the lining protecting film, cut, pack.
Embodiment 9
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 7 times of amount 75% ethanol extractions and reflux 3 times, each 2 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 4 parts of sodium polyacrylate, 2 parts of abundant swellings of carbomer water, get the A phase, second step: 0.3 part of ethyl hydroxybenzoate is added in 30 parts of glycerol, add again 0.2 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 8 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of tartaric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 part of eucalyptus oil behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 55 ℃ were dried by the fire 4 hours, and covered the lining protecting film, cut, pack.
Embodiment 10
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 10 times of amount 75% ethanol extractions and reflux 2 times, each 3 hours, filter with 100 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 3 parts of carbomers, 3 parts of abundant swellings of polyacrylic acid water, get the A phase, second step: 0.3 part of ethyl hydroxybenzoate is added in 20 parts of sorbitol, add again 0.3 part of aluminum sulfate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 5 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 5 parts of propylene glycol behind the colloid substance, 2 parts of carbamide stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 45 ℃ were dried by the fire 7 hours, and covered the lining protecting film, cut, pack.
Embodiment 11
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 8 times of amount 75% ethanol extractions and reflux 3 times, each 2 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of sodium polyacrylate, 3 parts of abundant swellings of carboxymethyl cellulose water, get the A phase, second step: 0.3 part of ethyl hydroxybenzoate is added in 20 parts of propylene glycol, add again 0.2 part of aluminum glycinate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 4 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 6 parts of propylene glycol behind the colloid substance, 3 portions of Oleum menthae stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 45 ℃ were dried by the fire 6 hours, and covered the lining protecting film, cut, pack.
Embodiment 12
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 6 times of amount 95% ethanol extractions and reflux 2 times, each 4 hours, filter with 100 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 3 parts of sodium polyacrylate, 3 parts of abundant swellings of polyvinylpyrrolidone water, get the A phase, second step: 0.3 part of ethyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.1 part of aluminium hydroxide and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 7 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 1 part of methyl salicylate behind the colloid substance, 3 parts of azones stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 40 ℃ were dried by the fire 5 hours, and covered the lining protecting film, cut, pack.
Embodiment 13
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 7 times of amount 75% ethanol extractions and reflux 3 times, each 2 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of sodium carboxymethylcellulose pyces, 2 parts of abundant swellings of polyvinyl alcohol water, get the A phase, second step: 0.3 part of ethyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.2 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 6 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 1 part of propylene glycol behind the colloid substance, 3 parts of eucalyptus oils stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 60 ℃ were dried by the fire 4 hours, and covered the lining protecting film, cut, pack.
Embodiment 14
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 8 times of amount 85% ethanol extractions and reflux 2 times, each 1 hour, filter with 100 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of carbomers, 3 parts of abundant swellings of zinc oxide water, get the A phase, second step: 0.3 part of methyl hydroxybenzoate is added in 20 parts of glycerol, add again 0.1 part of aluminum glycinate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 8 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 part of propylene glycol behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 6 hours, and covered the lining protecting film, cut, pack.
Embodiment 15
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 10 times of amount 65% ethanol extractions and reflux 3 times, each 3 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 2 parts of carbomers, 3 parts of abundant swellings of kaolin, get the A phase, second step: 0.3 part of benzoic acid is added in 20 parts of glycerol, add again 0.3 part of aluminum glycinate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 8 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 part of propylene glycol behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 8 hours, and covered the lining protecting film, cut, pack.
Embodiment 16
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 12 times of amount 60% ethanol extractions and reflux 3 times, each 4 hours, filter with 100 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 4 parts of carbomers, 1 part of abundant swelling of clay water, get the A phase, second step: 0.4 part of ethyl hydroxybenzoate is added in 20 parts of propylene glycol, the 10 parts of glycerol, add again 0.2 part of aluminum glycinate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 6 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 part of propylene glycol behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 60 ℃ were dried by the fire 4 hours, and covered the lining protecting film, cut, pack.
Embodiment 17
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 11 times of amount 65% ethanol extractions and reflux 2 times, each 3 hours, filter with 200 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 8 parts of abundant swellings of sodium polyacrylate water, get the A phase, second step: 0.4 part of ethyl hydroxybenzoate is added in 10 parts of propylene glycol, the 30 parts of glycerol, add again 0.3 part of aluminum glycinate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 6 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into and add again 1 part of propylene glycol behind the colloid substance and stir, namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 60 ℃ were dried by the fire 5 hours, and covered the lining protecting film, cut, pack.
Embodiment 18
Mallet fruit rattan is ground into coarse powder, crosses 40 mesh sieves, add 12 times of amount 70% ethanol extractions and reflux 2 times, each 3 hours, filter with 200 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 10 parts of abundant swellings of sodium polyacrylate water, get the A phase, second step: 0.5 part of ethyl hydroxybenzoate is added in 10 parts of propylene glycol, the 40 parts of glycerol, add again 0.3 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 7 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.4 part of tartaric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 1 part of propylene glycol behind the colloid substance, 5 parts of azones stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 5 hours, and covered the lining protecting film, cut, pack.
Embodiment 19
Mallet fruit rattan is ground into coarse powder, crosses 20 mesh sieves, add 10 times of amount 70% ethanol extractions and reflux 3 times, each 1 hour, filter with 200 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 6 parts of sodium polyacrylate, 3 parts of abundant swellings of polyacrylic acid water, get the A phase, second step: 0.5 part of ethyl hydroxybenzoate is added in 50 parts of glycerol, add again 0.5 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 7 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.5 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 5 parts of propylene glycol behind the colloid substance, 4 portions of Oleum menthae stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 6 hours, and covered the lining protecting film, cut, pack.
Embodiment 20
Mallet fruit rattan is ground into coarse powder, crosses 20 mesh sieves, add 8 times of amount 70% ethanol extractions and reflux 2 times, each 4 hours, filter with 200 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 6 parts of sodium polyacrylate, 3 parts of abundant swellings of sodium carboxymethyl cellulose water, get the A phase, second step: 0.5 part of ethyl hydroxybenzoate is added in 40 parts of glycerol, add again 0.1 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 7 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 5 parts of propylene glycol behind the colloid substance, 4 parts of eucalyptus oils stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 50 ℃ were dried by the fire 7 hours, and covered the lining protecting film, cut, pack.
Embodiment 21
Mallet fruit rattan is ground into coarse powder, crosses 20 mesh sieves, add 6 times of amount 70% ethanol extractions and reflux 2 times, each 2 hours, filter with 200 mesh sieves, merge 2 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 10 parts of abundant swellings of sodium polyacrylate water, get the A phase, second step: 0.5 part of ethyl hydroxybenzoate is added in 60 parts of glycerol, add again 0.5 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 8 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.5 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 5 parts of propylene glycol behind the colloid substance, 5 parts of azones stir, and namely get really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 55 ℃ were dried by the fire 5 hours, and covered the lining protecting film, cut, pack.
Embodiment 22
Mallet fruit rattan is ground into coarse powder, crosses 30 mesh sieves, add 11 times of amount 70% ethanol extractions and reflux 3 times, each 1 hour, filter with 200 mesh sieves, merge 3 times filtrate, Recycled ethanol is condensed into the fluid extract that every mL is equivalent to mallet fruit rattan 1g again, and drying namely gets mallet fruit rattan ethanol extraction powder; The preparation method of mallet fruit rattan cataplasma: the first step: with 5 parts of carbomers, 1 part of abundant swelling of Pulvis Talci water, get the A phase, second step: 0.5 part of ethyl hydroxybenzoate is added in 30 parts of glycerol, add again 0.3 part of dihydroxyaluminum aminoacetate and get the B phase, then the A phase is mixed mutually with B; The 3rd step: 2 parts of mallet fruit rattan ethanol extraction powder dispersing and dissolvings in water, are added 0.2 part of citric acid in the aqueous solution of mallet fruit rattan ethanol extraction again, dissolve to get the C phase; The 4th step: C is added to mutually in the mixed liquor of A phase and B phase, fully stir into add again 6 parts of propylene glycol behind the colloid substance, 1 part of Camphora stirs, and namely gets really rattan cataplasma mastic of mallet; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 55 ℃ were dried by the fire 4 hours, and covered the lining protecting film, cut, pack.
Claims (2)
1. the mallet fruit rattan cataplasma with effect of anti-inflammatory and antalgic is made by mallet fruit rattan ethanol extraction and cataplasma adjuvant as the anti-inflammatory and antalgic activity composition, it is characterized in that, wherein
1～8 part of mallet fruit rattan ethanol extraction,
Framework material≤10 part,
1～10 part of adhesive,
10～60 parts of wetting agents,
Filler≤5 part,
0.1～0.5 part of cross-linking agent,
0.1～0.5 part of pH adjusting agent,
0.1～0.5 part of antiseptic,
1～10 part of transdermal enhancer;
Described framework material is selected from gelatin, agar, alginic acid, methylcellulose, polyacrylic acid, carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, arabic gum, tragcanth;
Described adhesive is selected from polyacrylate, sodium alginate, carbomer, sodium carboxymethylcellulose pyce, sodium carboxymethyl cellulose;
Described wetting agent is selected from glycerol, sorbitol, propylene glycol;
Described filler is selected from Kaolin, clay, Pulvis Talci, zinc oxide;
Described cross-linking agent is selected from slaine;
Described pH adjusting agent is selected from citric acid, citric acid, tartaric acid, oleic acid;
Described antiseptic is selected from methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, benzoic acid;
Described transdermal enhancer is selected from methyl salicylate, azone, Camphora, propylene glycol, volatile oil;
Its preparation method comprises the steps:
The preparation process of mallet fruit rattan ethanol extraction: first mallet fruit rattan is ground into coarse powder, cross 10～40 mesh sieves, add ethanol extraction backflow 2-4 time that 6-12 doubly measures 60%-90%, each 1-3 hour, filter with 100～200 mesh sieves, merge filtrate 2-4 time, again Recycled ethanol, be condensed into the fluid extract that every ml is equivalent to mallet fruit rattan 1g, be drying to obtain mallet fruit rattan ethanol extraction powder;
The preparation process of mallet fruit rattan cataplasma:
The first step: with the abundant swelling of adhesive water, get the A phase, also add framework material at A in mutually, perhaps also add again filler at A in mutually, stir;
Second step: antiseptic is added in the wetting agent, add again cross-linking agent and get the B phase, then the B phase is mixed mutually with A;
The 3rd step: mallet fruit rattan ethanol extraction powder dispersing and dissolving in water, is added pH adjusting agent in the aqueous solution of mallet fruit rattan ethanol extraction powder again, dissolve to get the C phase;
The 4th step: C is added in A phase and the B mixed liquor mutually mutually, fully stir into and add again transdermal enhancer behind the colloid substance and stir, namely get mallet fruit rattan cataplasma mastic; At last mallet fruit rattan cataplasma mastic is evenly coated on the backing layer, 40-60 ℃ was dried by the fire 4～8 hours, and covered the lining protecting film, cuts, packs.
2. according to claim 1 mallet fruit rattan cataplasma is characterized in that described slaine is selected from aluminum chloride, aluminum sulfate, dihydroxyaluminum aminoacetate, aluminum glycinate, magnesium chloride, calcium chloride, aluminium hydroxide.
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| CN 200910113221 CN101474217B (en) | 2009-01-21 | 2009-01-21 | Antiphlogistic analgesic Capparis spinosa L. catablasm and preparation method thereof |
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| CN102399207B (en) * | 2010-09-14 | 2014-05-28 | 上海医药工业研究院 | Extraction method of ginkgetin or isoginkgetin |
| CN111690603B (en) * | 2020-06-22 | 2021-09-24 | 青岛赛尔斯干细胞库有限公司 | Biological agent for promoting proliferation and migration of dental pulp stem cells |
| CN113476489B (en) * | 2020-12-31 | 2022-10-11 | 成都中医药大学 | Ligusticum wallichii volatile oil plaster for treating dysmenorrhea as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541700A (en) * | 2003-11-05 | 2004-11-03 | 中国科学院新疆理化技术研究所 | Method for extracting active arthritis resisting element from Capparis fruit |
| CN101244099A (en) * | 2008-02-22 | 2008-08-20 | 浙江大学 | Method for preparing valid target in gavel fruit vine fruit and application of the same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541700A (en) * | 2003-11-05 | 2004-11-03 | 中国科学院新疆理化技术研究所 | Method for extracting active arthritis resisting element from Capparis fruit |
| CN101244099A (en) * | 2008-02-22 | 2008-08-20 | 浙江大学 | Method for preparing valid target in gavel fruit vine fruit and application of the same |
Non-Patent Citations (1)
| Title |
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| 张兆旺.外用膏剂-巴布剂的组成.《中药药剂学》.中国中医药出版社,2003,第319页. * |
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