CN101472584B - 用作组胺h4受体调节剂的吲哚类和苯并咪唑类 - Google Patents

用作组胺h4受体调节剂的吲哚类和苯并咪唑类 Download PDF

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Publication number
CN101472584B
CN101472584B CN200780021127XA CN200780021127A CN101472584B CN 101472584 B CN101472584 B CN 101472584B CN 200780021127X A CN200780021127X A CN 200780021127XA CN 200780021127 A CN200780021127 A CN 200780021127A CN 101472584 B CN101472584 B CN 101472584B
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ketone
indole
pyrrolidin
methylamino
octahydro
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Expired - Fee Related
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Chinese (zh)
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CN101472584A (zh
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J·P·爱德华兹
B·M·萨瓦尔
C·R·沙
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
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  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200780021127XA 2006-04-07 2007-03-30 用作组胺h4受体调节剂的吲哚类和苯并咪唑类 Expired - Fee Related CN101472584B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79042106P 2006-04-07 2006-04-07
US60/790,421 2006-04-07
PCT/US2007/008218 WO2007117401A2 (en) 2006-04-07 2007-03-30 Indoles and benzoimidazoles as modulators of the histamine h4 receptor

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CN101472584A CN101472584A (zh) 2009-07-01
CN101472584B true CN101472584B (zh) 2013-04-24

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US (1) US7544698B2 (enExample)
EP (1) EP2010172B1 (enExample)
JP (1) JP5132673B2 (enExample)
CN (1) CN101472584B (enExample)
AU (1) AU2007235578B2 (enExample)
WO (1) WO2007117401A2 (enExample)

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ATE478067T1 (de) 2006-03-31 2010-09-15 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyridine und pyrazine als modulatoren des histamin-h4-rezeptors
WO2007120690A2 (en) * 2006-04-10 2007-10-25 Janssen Pharmaceutica N.V. Combination histamine h1r and h4r antagonist therapy for treating pruritus
PT2354124E (pt) 2006-12-19 2013-04-09 Hoffmann La Roche Derivados de heteroaril-pirrolidinilo e piperidinil-cetona
CN101842098A (zh) * 2007-08-10 2010-09-22 基因实验室技术有限公司 用于治疗病毒感染的含氮的二环化学实体
UA100567C2 (ru) * 2008-06-12 2013-01-10 Янссен Фармацевтика Нв Использование антагонистов н4-гистаминовых рецепторов для лечения послеоперационных спаек
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
US8436008B2 (en) 2008-12-22 2013-05-07 Incyte Corporation Substituted heterocyclic compounds
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
TW201035078A (en) 2009-03-20 2010-10-01 Incyte Corp Substituted heterocyclic compounds
US20120277238A1 (en) * 2009-07-31 2012-11-01 Shionogi & Co., Ltd Pharmaceutical composition containing fused hetero-ring derivative
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
HUE039713T2 (hu) 2012-06-08 2019-02-28 Sensorion H4 receptor inhibitorok tinnitus kezelésére
AR092211A1 (es) * 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
JO3516B1 (ar) 2013-03-06 2020-07-05 Janssen Pharmaceutica Nv مُعدِّلات بنزإيميدازول-2-يل بيريميدين لمستقبل الهستامين h4
WO2019152883A1 (en) 2018-02-02 2019-08-08 Padforward Llc Inhibitors of protein arginine deiminases
AR133293A1 (es) * 2023-07-18 2025-09-17 Muna Therapeutics Aps Antagonistas del canal de potasio kv1.3
WO2025101780A1 (en) * 2023-11-08 2025-05-15 Octant, Inc. Pharmacological correctors of rhodopsin and uses thereof
WO2026096386A1 (en) 2024-10-28 2026-05-07 Octant, Inc. Pharmacological correctors of rhodopsin and uses thereof

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MXPA05002575A (es) * 2002-09-06 2005-09-08 Johnson & Johnson Compuestos heterociclicos.
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WO2005054239A1 (en) * 2003-12-05 2005-06-16 Bayer Healthcare Ag 2-aminopyrimidine derivatives
US20060111416A1 (en) * 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
BRPI0810082A2 (pt) * 2007-03-29 2014-10-21 Novartis Ag 3-imidazolil-indóis para o tratamento de doenças proliferativas

Patent Citations (1)

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CA2592611A1 (en) * 2005-01-12 2006-07-20 Dainippon Sumitomo Pharma Co., Ltd. 2-(cyclic aminocarbonyl)indoline derivative and medicinal composition containing the same

Non-Patent Citations (1)

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HK1125034A1 (en) 2009-07-31
WO2007117401A2 (en) 2007-10-18
AU2007235578B2 (en) 2011-07-14
US7544698B2 (en) 2009-06-09
JP2009533343A (ja) 2009-09-17
EP2010172A2 (en) 2009-01-07
AU2007235578A1 (en) 2007-10-18
EP2010172B1 (en) 2012-08-29
JP5132673B2 (ja) 2013-01-30
WO2007117401A3 (en) 2008-06-26
EP2010172A4 (en) 2010-03-31
CN101472584A (zh) 2009-07-01
US20070238771A1 (en) 2007-10-11

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