CN101468218A - Dry powder inhaler device for pulmonary delivery and working method thereof - Google Patents
Dry powder inhaler device for pulmonary delivery and working method thereof Download PDFInfo
- Publication number
- CN101468218A CN101468218A CNA2008101875734A CN200810187573A CN101468218A CN 101468218 A CN101468218 A CN 101468218A CN A2008101875734 A CNA2008101875734 A CN A2008101875734A CN 200810187573 A CN200810187573 A CN 200810187573A CN 101468218 A CN101468218 A CN 101468218A
- Authority
- CN
- China
- Prior art keywords
- gear
- inhaler
- knob
- medicine
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The present invention provides a dry powder inhaler for feeding medicine to lung and an operating method thereof. The dry powder inhaler is composed of an inhaler casing, an internal gear assembly of inhaler, a knob transmission gear assembly and a self-locking device. The invention has the advantages: (1) the inhaler can be filled with medicinal foil repeatedly for reusing and the counting is convenient, and the medicinal foil can be taken out or refilled for reusing if necessary; (2) the dry powder inhaler has the advantages of convenient carrying, quick use and easy operation; (3) CFC fluoric ether is not contained and pure medicine can be used; (4) the maintenance is not required; (5) the medicine particles are dispersed through the kinetic energy of inducted air of user, the flow velocity of particles corresponds with the flow velocity of inducted air of user, and furthermore the medicine is output with a form of dry powder particle, therefore the size of dry powder medicine after leaving the suction device does not change quickly along with the variation of time and distance, the dry powder particle is more stable; and (6) the remaining amount at the pharynx oralis is little when the dry powder preparation is taken because of the difference of flow velocity of gas and air current mode.
Description
(1) technical field:
The present invention relates to be used for the Diskus tool of pulmonary administration, this device is convenient to the user and is carried, and is easy to operate, and the suction that the given dose medicine can be provided is to reach the purpose of treatment disease.
(2) background technology:
Powder spray (powder inhalation, PI) be meant one or more medicine, enter respiratory tract with dry powder form after special doser administration, a kind of drug-supplying system of performance whole body or local action has targeting, efficient, quick-acting, characteristics such as toxic and side effects is little.According to the difference of medicine-feeding part, can be divided into per nasal and use (lung suction) powder spray with powder spray with through the oral cavity.
At present, the dust cloud inhalation dosage form that pulmonary discharges generally is divided into three kinds, be metered dose inhalation aerosol (Metered Dose Inhaler, MDI), atomized inhalation (Nebulizer) and solubility Foradil Aerolizer formoterol fumarate (Dry Powder Inhaler is abbreviated as DPI).
Because the medicine in the powder spray is to absorb by the abundant blood capillary of pulmonary to enter blood, so than oral and injection type, absorption area is bigger, infiltration rate is faster, thereby, have following characteristics: (1) no gastrointestinal tract Degradation as the respiratory mucosa absorbable preparation; (2) no liver first-pass effect; (3) drug absorption is rapid, and is rapid-action after the administration; (4) bioavailability of macromolecular drug can be by the improve that should be used for of absorption enhancer or additive method; (5) small-molecule drug is particularly useful for respiratory tract and directly sucks or spray into administration: directly enter the body circulation after (6) drug absorption, reach the purpose of whole body therapeutic; (7) can be used for the big medicine of water solublity that gastrointestinal tract is difficult to absorb; (8) good patient compliance is specially adapted to the patient that former need carry out the long term injections treatment; (9) play the medicine of local action, dosage obviously reduces, and toxic and side effects is little.
Certainly, the suction-type pulmonary administration also has some unique technique difficult points, absorbs because powder spray is a respiratory system by the people, and human body vesicular breathing road always has bifurcated 23 times, and surface area has 70～80 square metres approximately, and the film blood vessel of alveolar also is a monofilm.If dry powder sucks the medicine that absorbs by pulmonary, molecular weight is big just is difficult to absorb, and the powder diameter is greater than 5～6 μ m, also be difficult to absorb, the medicine that protein binding rate is low also is difficult to absorb, if this class medicine of insulin reaches the particle diameter of 2 μ m, just can directly absorb by pulmonary.
Medicine is to enter in the body with the form output of aerosol (aerosol) and with breathing by inhalation apparatus when sucking treatment.Aerosol has huge contact surface, helps medicine and contacts with airway surface and play a role, but have cohesion simultaneously.Aerocolloidal flowability depends on that the external world gives its initial velocity, and its settlement action is followed the Stoke law substantially, and promptly sedimentation velocity is directly proportional with granular mass.The motion mode of dry-powder medicament in lung mainly contains following 3 kinds of (1) disperse campaigns (diffusion), or is called the Brownian motion, and be relevant with the microparticle size with the time, and irrelevant with the particulate density of medicine mist; (2) gravitational motion (gravitational transport) or be referred to as subsiding movement (sedimentation), all relevant with the size and the density of time, microparticle; The size of (3) inertia motion (inertial transport) gettering rate, microparticle is relevant with density.Therefore since the difference of the size of the characteristics of conveyer device, drug particles, form, molecular weight, electric charge, moisture absorption etc. suck medicine and can produce different clinical effects.With regard to granular size, the drug particles of diameter 1～5 μ m is the most suitable, be referred to as to suck granule, greater than the granule of 5 μ m then the overwhelming majority be trapped within pars oralis pharyngis, finally enter in the body through swallowing, though and can reach lower respiratory tract less than the granule of 0.5 μ m, 90% microgranule excretes with expiration again when moisture is breathed.
Therefore, the pulmonary administration mode depends on administration apparatus to a great extent, it is good that ideal Diskus should possess the medicine of conveying usefulness, output dose and microparticle constant magnitude, can reach the influence that suitable pulmonary drug deposition is not subjected to inspiratory flow rate, drug distribution in the good lung is arranged, and pars oralis pharyngis medicine retention amount is less.Convenient to use, be the multiple dose device.Characteristics such as the harmony that sucks technology is required low, it is wide to be suitable for the range of age, lightly is easy to carry about with one, and does not contain the additive that patient or environment are unfavorable for, need not maintenance, economical and practical.
This is the problem that the present invention need solve.
(3) summary of the invention:
The invention provides a kind of dry powder inhaler device and method of work thereof that is used for pulmonary administration, this device relies on the strength of being pushed generation by the user, drive the medicine paper tinsel of the incompatible transmission given dose of the gear train dry-powder medicament of device inside, locate the opening encapsulation paillon foil by the groove of gear, the user begins to be undertaken air-breathing by the DPI suction nozzle, the dry-powder medicament of setting dosage is sucked pulmonary, thereby reach therapeutic effect.These apparatus and method have strengthened the air velocity in the dry powder inhaler device (DPI) and have sucked dry powder particle more fully so that suck air-flow; The present invention has strengthened fixed gear combination, reaches the purpose that transmits the medicine paper tinsel, has also increased simultaneously to prevent the counter-rotational self-locking device of gear.
Technical scheme of the present invention: a kind of dry powder inhaler device of pulmonary administration, it is characterized in that it is by inhaler shell, the combination of inhaler internal gear, the combination of knob travelling gear and prevent that the self-locking device of groove reset gear from being constituted, fixed card slot, Diskus suction nozzle, breather and the pore of fixed housing arranged on the said inhaler shell; The combination of said inhaler internal gear comprises master gear, play that branchs writes a prescription that the A gear of chaff effect is rolled up and A sprocket spool and the B gear rolls up and B sprocket spool, the groove gear and the governor gear that play the role of positioning, master gear meshes A gear volume respectively and rolls up by governor gear engagement B gear, the groove gear places the boundary of separated medicine chaff, and this place and Diskus suction nozzle are identical shape; The combination of said knob travelling gear is made of knob and knob travelling gear A, B, C, external force acts on the input of knob, the outfan engagement knob travelling gear A of knob, the outfan engagement knob travelling gear B of knob travelling gear A, knob travelling gear B is coaxial with knob travelling gear C, the input of the master gear during then the outfan of knob travelling gear C engagement inhaler internal gear makes up, the axial region of master gear is connected with knob; Said pore is close in Diskus suction nozzle place according to breather; Said self-locking device acts on the lower shaft of groove gear; Said medicine chaff is wrapped on the gear shaft of master gear, and the aluminum foil strip initial end is to be fit together by two aluminium foil A, B face, and aluminium foil A, B link to each other with B gear volume with A gear volume according to draw-in groove respectively, and its boundary end is in the junction of groove gear and shell suction nozzle.
The above-mentioned said self-locking device that prevents the groove reset gear is the ratchet of braking action together, and its lower shaft with the groove gear is done to brake and contacted.
The fixed card slot that four fixed housings are arranged on the above-mentioned said inhaler shell.
On the above-mentioned said inhaler shell registration window is arranged, the registration window is positioned on the counting gear that registration is arranged; Said counting gear is engaged in the lower shaft of master gear.
A kind of method of work of dry powder inhaler device of as above-mentioned said pulmonary administration is characterized in that it may further comprise the steps:
(1) open Diskus: artificial turn knob counterclockwise encloses, the turn knob is by the moving master gear of knob travelling gear assemblage zone, master gear is according to the moving lattice of the motion revolution of internal gear combination, medicine chaff on the master gear is divided into aluminium foil A, B group, be rolled into respectively on A gear volume and the B gear volume, the junction that its boundary end place is groove gear and shell suction nozzle is positioned and tears a medicine chaff bubble-cap in advance;
(2) prepare to suck: a groove at suction nozzle 1 alignment indentation gear place, a bubble-cap dose drug of medicine chaff is opened, in order to sucking;
(3) suck: user is aimed at suction nozzle, keeps the inhaler balance and suction nozzle is contained in the inlet, steadily breathes, and sucks medicine as far as possible, fully behind air-breathing the finishing, the automatic reposition of knob, for the use of next suction ready;
(4) close: behind abundant air-breathing finishing, as next suction of need, above-mentioned steps (1) (2) (3) repeats to get final product;
(5) time spent not, all inhaler device reset in shell, the cleaning of protection inhaler suction nozzle.
The points for attention of above-mentioned said step (1) are: acutely do not rock inhaler; Do not exhale facing to the inhaler suction nozzle; Guarantee when needs use medicine, to press again the inhaler knob; Using dosage should be followed the doctor's advice.
The medicine of the opened bubble-cap dosage of inhaler during above-mentioned said step (2), and carry out and inhale preceding all preparations of medicine, can have the corresponding demonstration for user observed at the dosage indication window this moment.
Above-mentioned said step (3) must be taken out inhaler after sucking from the user mouth, be sure not to go into from snuffing.
Superiority of the present invention is: (1) this inhaler can repeat to load the medicine paper tinsel and use, and convenient counting as needs, can take out the medicine paper tinsel or load again and reuse; (2) Diskus have easy to carry, use quick, processing ease; (3) do not contain CFC fluoroalkane hydro carbons, can use pure medicine; (4) need not keep in repair; (5) initiatively suck the kinetic energy dispersion medicine microgranule of air by user, match with the flow velocity of powder particles and the inspiratory flow rate of user, and medicine is exported with the dry powder particle form, therefore rapid variation can not take place because of the variation of time and distance in the size of dry-powder medicament microparticle after leaving suction apparatus, and dry powder particle is more stable; (6) because gas velocity and streamer mode different, pars oralis pharyngis retention amount is less when using dry powder doses to suck.
(4) description of drawings:
Accompanying drawing 1 is the Facad structure view of the dry powder inhaler device of the related a kind of pulmonary administration of the present invention.
Wherein: 1 is the DPI suction nozzle, and 2 is breather, and 3 is fixed card slot, and 4 is pore, 5 is self-locking device, and 6 are A gear volume, and 6-1 is the A sprocket spool, and 7 is master gear, 7-1 is a main gear shaft, and 8 are B gear volume, and 8-1 is the B sprocket spool, 9 is the groove gear, and 10 is knob, and 11 is governor gear, 12 is knob travelling gear A, and 13 is knob travelling gear B, and 14 is counting gear, 15 is knob travelling gear C, and 16 is shell, and 17 is registration window (at the shell of device).
(5) specific embodiment:
Embodiment: a kind of dry powder inhaler device of pulmonary administration (seeing accompanying drawing), it is characterized in that it is by inhaler shell 16, the combination of inhaler internal gear, knob travelling gear combination 10,12,13,15 and prevent that the self-locking device 5 that groove gear 9 resets from being constituted, fixed card slot 3, Diskus suction nozzle 1, the breather 2 and pore 4 of fixed housing arranged on the said inhaler shell 16; The combination of said inhaler internal gear comprises master gear 7, play the write a prescription A gear volume 6 of chaff effect and A sprocket spool 6-1 and B gear of branchs rolls up 8 and B sprocket spool 8-1, the groove gear 9 and the governor gear 11 that play the role of positioning, master gear 7 meshes A gear volume 6 respectively and rolls up 8 by governor gear 11 engagement B gears, groove gear 9 places the boundary of separated medicine chaff, and this place and Diskus suction nozzle 1 are identical shape; The combination of said knob travelling gear is made of knob 10 and knob travelling gear A, B, C, external force acts on the input of knob 10, the outfan engagement knob travelling gear A12 of knob 10, the outfan engagement knob travelling gear B13 of knob travelling gear A12, knob travelling gear B13 is coaxial with knob travelling gear C15, the input of the master gear 7 during then the outfan of knob travelling gear C15 engagement inhaler internal gear makes up, the axial region 7-1 of master gear 7 is connected with knob 10; Said pore 4 is close in Diskus suction nozzle 1 place according to breather 2; Said self-locking device 5 acts on the lower shaft of groove gear 9; Said medicine chaff is wrapped on the gear shaft 7-1 of master gear 7, the aluminum foil strip initial end is to be fit together by two aluminium foil A, B face, aluminium foil A, B link to each other with B gear volume 8 with A gear volume 6 according to draw-in groove respectively, and its boundary end is in the junction of groove gear 9 and shell suction nozzle 1.
Above-mentionedly saidly prevent that self-locking device 5 that groove gear 9 resets from being the ratchet of braking action together, its lower shaft with groove gear 9 is done to brake and is contacted.
The fixed card slot that four fixed housings are arranged on the above-mentioned said inhaler shell 16.
On the above-mentioned said inhaler shell 16 registration window 17 is arranged, registration window 17 is positioned on the counting gear 14 that registration is arranged; Said counting gear 14 is engaged in the lower shaft of master gear 7.
Method of work as the dry powder inhaler device of above-mentioned said pulmonary administration is characterized in that it may further comprise the steps:
(1) opens Diskus: artificial turn knob 10 counterclockwise circles, turn knob 10 is by the moving master gear 7 of knob travelling gear assemblage zone, master gear 7 is according to the moving lattice of the motion revolution of internal gear combination, medicine chaff on the master gear 7 is divided into aluminium foil A, B group, be rolled into respectively on A gear volume 6 and the B gear volume 8, the junction that its boundary end place is groove gear 9 and shell suction nozzle 1 is positioned and tears a medicine chaff bubble-cap in advance;
(2) prepare to suck: a groove at suction nozzle 1 alignment indentation gear 9 places, a bubble-cap dose drug of medicine chaff is opened, in order to sucking;
(3) suck: user is aimed at suction nozzle, keeps the inhaler balance and suction nozzle is contained in the inlet, steadily breathes, and sucks medicine as far as possible, and fully behind air-breathing the finishing, knob 10 automatic repositions are for the use of next suction is got ready;
(4) close: behind abundant air-breathing finishing, as next suction of need, above-mentioned steps (1) (2) (3) repeats to get final product;
(5) time spent not, all inhaler device reset in shell, the cleaning of protection inhaler suction nozzle.
The points for attention of above-mentioned said step (1) are: acutely do not rock inhaler; Do not exhale facing to the inhaler suction nozzle; Guarantee when needs use medicine, to press again the inhaler knob; Using dosage should be followed the doctor's advice.
The medicine of the opened bubble-cap dosage of inhaler during above-mentioned said step (2), and carry out and inhale preceding all preparations of medicine, can have the corresponding demonstration for user observed at dosage indication window 17 this moment.
Above-mentioned said step (3) must be taken out inhaler after sucking from the user mouth, be sure not to go into from snuffing.
The dry-powder medicament of its Chinese medicine chaff built-in 20-200 grain white or off-white color is sealed in the aluminum foil strip, and this aluminum foil strip is wrapped in 7 master gears.
Wherein the registration window shows residual drug.With shown in red, warning residue dosage is few when using last dosage and be 5～0.
Operation principle of the present invention is: the dry powder inhaler device that the invention provides a kind of novel pulmonary administration, this device relies on the strength of being pushed generation by the user, drive the medicine paper tinsel of the incompatible transmission given dose of the gear train dry-powder medicament of device inside, promptly act on the aggregate motion that knob 10 interlock master gears 7 cause internal gear by external force, master gear 7 is according to the moving lattice of the motion revolution of internal gear combination, medicine chaff on the master gear 7 is divided into aluminium foil A, the B group, be rolled into respectively on A gear volume 6 and the B gear volume 8, to be groove gear 9 in boundary end place with the junction of DPI suction nozzle 1 be positioned tears a bubble-cap, the medicated powder that user this moment can suck in the bubble-cap of opening by suction nozzle 1, make the dry-powder medicament of setting dosage suck pulmonary, thereby reach therapeutic effect.Structure of the present invention has strengthened the air velocity in the dry powder suction (DPI) and has sucked dry powder particle more fully so that suck air-flow.Of the present invention by fixed gear combination, reach the purpose that transmits the medicine paper tinsel, also provide simultaneously to prevent the counter-rotational self-locking device of gear.
The treatment field that is applicable to inhaler among the present invention includes but not limited to:
Respiratory system such as asthma, COPD obstacle
The obstacle of muscle or neuromuscular system
The disorder of digestive tract or digestive system
The obstacle of cardio-cerebrovascular
The imbalance of hormonal system
Reproduction or sexual dysfunction
Neural obstacle
Anaphylactic disease
The psychiatric department disease
Infect
Pain
Include but not limited to the medicine selected from following:
Zanamivir, codeine, paramorphane, Ergotamine, sweet smell is the slave too, morphine, diltiazem, cromoglycate, cephalosporins, penicillin, streptomycin, sulfonamides, tetracycline, beclometasone, dipropionate, Fluticasone Propionate, flunisolide, fluticasone, budesonide, budesonide sulfur, the acid albuterol, the ephedrine class, adrenin, fenoterol, formoterol, risperidone, nifedipine, sulindac, tibolone, stavudine, Carclura, rapamycin, glipizide, triamcinolone acetonide, alprazolam, midazolam, romilar, indinavir, Nateglinide, different third (nor-) epinephrine, two antelope propyloxy phenyl ethylaminoethanols, phenylpropanolamine HC1, adjoin Boot sieve acetate, cortisone, hydrocortisone or andrographolide, aminophylline, the choline theophylline, tiotropium bromide, tetanus toxoid, calcitonin, insulin or glucagon, or salt, vinegar, or its chemical compound alone or in combination.
Include but not limited to the biological product selected from following:
Vaccine (with virus, rickettsia makes immune serum, comprises antitoxin, antibiotic and antiviral serum) as: various blood products, organize goods, nonspecific immunity goods and little ecological goods etc.Human albumin, human, interleukin, interferon, thymosin and cereobiogen, house Rayleigh, multi-joint multivalence goods or mix preparations such as oxytocin, somatostatin, Sermorelin, octreotide, leuprorelin and various cytokines.
Claims (9)
1, a kind of dry powder inhaler device of pulmonary administration, it is characterized in that it is by inhaler shell, the combination of inhaler internal gear, the combination of knob travelling gear and prevent that the self-locking device of groove reset gear from being constituted, fixed card slot, Diskus suction nozzle, breather and the pore of fixed housing arranged on the said inhaler shell; The combination of said inhaler internal gear comprises master gear, play that branchs writes a prescription that the A gear of chaff effect is rolled up and A sprocket spool and the B gear rolls up and B sprocket spool, the groove gear and the governor gear that play the role of positioning, master gear meshes A gear volume respectively and rolls up by governor gear engagement B gear, the groove gear places the boundary of separated medicine chaff, and this place and Diskus suction nozzle are identical shape; The combination of said knob travelling gear is made of knob and knob travelling gear A, B, C, external force acts on the input of knob, the outfan engagement knob travelling gear A of knob, the outfan engagement knob travelling gear B of knob travelling gear A, knob travelling gear B is coaxial with knob travelling gear C, the input of the master gear during then the outfan of knob travelling gear C engagement inhaler internal gear makes up, the axial region of master gear is connected with knob; Said pore is close in Diskus suction nozzle place according to breather; Said self-locking device acts on the lower shaft of groove gear; Said medicine chaff is wrapped on the gear shaft of master gear, and the aluminum foil strip initial end is to be fit together by two aluminium foil A, B face, and aluminium foil A, B link to each other with B gear volume with A gear volume according to draw-in groove respectively, and its boundary end is in the junction of groove gear and shell suction nozzle.
2, according to the dry powder inhaler device of the said a kind of pulmonary administration of claim 1, it is characterized in that the said self-locking device that prevents the groove reset gear is the ratchet of braking action together, its lower shaft with the groove gear is done to brake and is contacted.
3,, it is characterized in that having on the said inhaler shell fixed card slot of four fixed housings according to the dry powder inhaler device of the said a kind of pulmonary administration of claim 1.
4, according to the dry powder inhaler device of the said a kind of pulmonary administration of claim 1, it is characterized in that on the said inhaler shell registration window being arranged, the registration window is positioned on the counting gear that registration is arranged; Said counting gear is engaged in the lower shaft of master gear.
5, a kind of method of work of dry powder inhaler device of as above-mentioned said pulmonary administration is characterized in that it may further comprise the steps:
(1) open Diskus: artificial turn knob counterclockwise encloses, the turn knob is by the moving master gear of knob travelling gear assemblage zone, master gear is according to the moving lattice of the motion revolution of internal gear combination, medicine chaff on the master gear is divided into aluminium foil A, B group, be rolled into respectively on A gear volume and the B gear volume, the junction that its boundary end place is groove gear and shell suction nozzle is positioned and tears a medicine chaff bubble-cap in advance;
(2) prepare to suck: a groove at suction nozzle 1 alignment indentation gear place, a bubble-cap dose drug of medicine chaff is opened, in order to sucking;
(3) suck: user is aimed at suction nozzle, keeps the inhaler balance and suction nozzle is contained in the inlet, steadily breathes, and sucks medicine as far as possible, fully behind air-breathing the finishing, the automatic reposition of knob, for the use of next suction ready;
(4) close: behind abundant air-breathing finishing, as next suction of need, above-mentioned steps (1) (2) (3) repeats to get final product;
(5) time spent not, all inhaler device reset in shell, the cleaning of protection inhaler suction nozzle.
6, according to the method for work of the dry powder inhaler device of the said a kind of pulmonary administration of claim 5, it is characterized in that the points for attention of described step (1) are: acutely do not rock inhaler; Do not exhale facing to the inhaler suction nozzle; Guarantee when needs use medicine, to press again the inhaler knob; Using dosage should be followed the doctor's advice.
7, according to the method for work of the dry powder inhaler device of the said a kind of pulmonary administration of claim 5, the medicine of the opened bubble-cap dosage of inhaler when it is characterized in that described step (2), and carry out and inhale preceding all preparations of medicine, can have the corresponding demonstration for user observed at the dosage indication window this moment.
8, according to the method for work of the dry powder inhaler device of the said a kind of pulmonary administration of claim 5, it is characterized in that inhaler to be taken out from the user mouth after described step (3) sucks, be sure not to go into from snuffing.
9, a kind of application of dry powder inhaler device of as above-mentioned said novel pulmonary administration is characterized in that it comprises following aspect:
(1) the treatment field that is applied to inhaler includes but not limited to:
Respiratory system such as asthma, COPD obstacle
The obstacle of muscle or neuromuscular system
The disorder of digestive tract or digestive system
The obstacle of cardio-cerebrovascular
The imbalance of hormonal system
Reproduction or sexual dysfunction
Neural obstacle
Anaphylactic disease
The psychiatric department disease
Infect
Pain
(2) include but not limited to the medicine selected from following:
Zanamivir, codeine, paramorphane, Ergotamine, sweet smell is the slave too, morphine, diltiazem, cromoglycate, cephalosporins, penicillin, streptomycin, sulfonamides, tetracycline, beclometasone, dipropionate, Fluticasone Propionate, flunisolide, fluticasone, budesonide, budesonide sulfur, the acid albuterol, the ephedrine class, adrenin, fenoterol, formoterol, risperidone, nifedipine, sulindac, tibolone, stavudine, Carclura, rapamycin, glipizide, triamcinolone acetonide, alprazolam, midazolam, romilar, indinavir, Nateglinide, different third (nor-) epinephrine, two antelope propyloxy phenyl ethylaminoethanols, phenylpropanolamine HC1, adjoin Boot sieve acetate, cortisone, hydrocortisone or andrographolide, aminophylline, the choline theophylline, tiotropium bromide, tetanus toxoid, calcitonin, insulin or glucagon, or salt, vinegar, or its chemical compound alone or in combination.
(3) include but not limited to the biological product selected from following:
Vaccine (with virus, rickettsia makes immune serum, comprises antitoxin, antibiotic and antiviral serum) as: various blood products, organize goods, nonspecific immunity goods and little ecological goods etc.Human albumin, human, interleukin, interferon, thymosin and cereobiogen, house Rayleigh, multi-joint multivalence goods or mix preparations such as oxytocin, somatostatin, Sermorelin, octreotide, leuprorelin and various cytokines.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101875734A CN101468218B (en) | 2007-12-28 | 2008-12-26 | Dry powder inhaler device for pulmonary delivery and working method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710060593.0 | 2007-12-28 | ||
| CN200710060593 | 2007-12-28 | ||
| CN2008101875734A CN101468218B (en) | 2007-12-28 | 2008-12-26 | Dry powder inhaler device for pulmonary delivery and working method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101468218A true CN101468218A (en) | 2009-07-01 |
| CN101468218B CN101468218B (en) | 2010-12-01 |
Family
ID=40826182
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101875734A Expired - Fee Related CN101468218B (en) | 2007-12-28 | 2008-12-26 | Dry powder inhaler device for pulmonary delivery and working method thereof |
| CNU2008201828692U Expired - Lifetime CN201337727Y (en) | 2007-12-28 | 2008-12-26 | Dry powder inhaler device for pulmonary drug delivery |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008201828692U Expired - Lifetime CN201337727Y (en) | 2007-12-28 | 2008-12-26 | Dry powder inhaler device for pulmonary drug delivery |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN101468218B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104363942A (en) * | 2012-04-05 | 2015-02-18 | 艾尔弗雷德.冯舒克曼 | Device for the portioned output of medications |
| CN108144169A (en) * | 2015-05-16 | 2018-06-12 | 苏州汉方医药有限公司 | A kind of safflower medicine box for the treatment angiocardiopathy that medicine instrument is combined into |
| CN108883238A (en) * | 2016-03-24 | 2018-11-23 | 尼科创业控股有限公司 | Steam providing apparatus |
| US11123501B2 (en) | 2016-03-24 | 2021-09-21 | Nicoventures Holdings Limited | Electronic vapor provision system |
| US11213638B2 (en) | 2016-03-24 | 2022-01-04 | Nicoventures Trading Limited | Vapor provision system |
| US11241043B2 (en) | 2016-03-24 | 2022-02-08 | Nicoventures Trading Limited | Vapor provision apparatus |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9707660A (en) * | 1996-02-21 | 2001-10-30 | Schering Corp | Powder medication inhaler |
| EP1330282B1 (en) * | 2000-10-31 | 2005-12-07 | Glaxo Group Limited | Medicament dispenser |
-
2008
- 2008-12-26 CN CN2008101875734A patent/CN101468218B/en not_active Expired - Fee Related
- 2008-12-26 CN CNU2008201828692U patent/CN201337727Y/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104363942A (en) * | 2012-04-05 | 2015-02-18 | 艾尔弗雷德.冯舒克曼 | Device for the portioned output of medications |
| CN108144169A (en) * | 2015-05-16 | 2018-06-12 | 苏州汉方医药有限公司 | A kind of safflower medicine box for the treatment angiocardiopathy that medicine instrument is combined into |
| CN108883238A (en) * | 2016-03-24 | 2018-11-23 | 尼科创业控股有限公司 | Steam providing apparatus |
| US11123501B2 (en) | 2016-03-24 | 2021-09-21 | Nicoventures Holdings Limited | Electronic vapor provision system |
| US11213638B2 (en) | 2016-03-24 | 2022-01-04 | Nicoventures Trading Limited | Vapor provision system |
| US11241043B2 (en) | 2016-03-24 | 2022-02-08 | Nicoventures Trading Limited | Vapor provision apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101468218B (en) | 2010-12-01 |
| CN201337727Y (en) | 2009-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101468218B (en) | Dry powder inhaler device for pulmonary delivery and working method thereof | |
| CN101384288B (en) | Dry powder inhaler device | |
| CN103998087B (en) | For sucking the atomising device of distribution independence administration | |
| CN101980739B (en) | Inhalation device | |
| US6526969B2 (en) | Method and device for releasing powder | |
| EP2526990A2 (en) | A dry powder for inhalation | |
| BG105377A (en) | Method and device for supplying aerosol-active agent of modulated flow resistance | |
| CN102470223A (en) | Nebulizer for infants and respiratory compromised patients | |
| US20060002995A1 (en) | Pharmaceutical porous particles | |
| KR20150031315A (en) | Dry powder drug delivery systems and methods | |
| US11571528B2 (en) | Dry powder nebulizer | |
| CN102802707A (en) | Device for oral administration of an aerosol for the rhinopharynx, the nasal cavities or the paranasal sinuses | |
| CN1253509A (en) | Method of delivering halotherapy | |
| US20130025593A1 (en) | Dry powder inhaler | |
| AU2004325349A1 (en) | A resonating (alerting) metered dose inhaler | |
| CN201361332Y (en) | Oval dry-powder absorber | |
| KR101992171B1 (en) | Inhaler for dry powder | |
| CN201182811Y (en) | Dry powder inhaler convenient for carrying | |
| AU2003287132B2 (en) | Pharmaceutical porous particles | |
| RU2610779C1 (en) | Single dose dry powder inhaler | |
| CN201361331Y (en) | Circular dry-powder absorber | |
| CN201361330Y (en) | Portable passette dry-powder absorber | |
| JP4266399B2 (en) | Pharmaceutical composition for inhalation in powder form | |
| CN201131997Y (en) | A dry power inhalation device | |
| WO2008139490A2 (en) | A multi dose dry powder inhaler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101201 Termination date: 20151226 |
|
| EXPY | Termination of patent right or utility model |