CN201361332Y - Oval dry-powder absorber - Google Patents

Abstract

The utility model relates to an oval dry-powder absorber, comprising a housing and an inner gear component of the absorber. The utility model is characterized in that the housing is internally provided with an absorber suction nozzle and a rotary knob. The utility model has the advantages that: (1) the absorber can be used repeatedly by refilling medical foil, thus facilitating the counting; if needed, the medical foil can be taken out or be refilled for using repeatedly; (2) the dry-powder absorber is portable, can be used fast and conveniently and can be operated simply; (3) CFC fluoro-alkane is not contained and pure medicine can be used; (4) the maintenance is not needed; (5) the energy of the air, which is actively absorbed by a user, can disperse the medical particles which are identical with the flowing speed of the powder particles and the air absorbing speed of the user; and medicine is output in a way of dry-powder particles, so that when the dry-powder medicine gets off the absorber, the size of the micro particles will not change quickly by following the change of time and distance, and the dry-powder particles will be more stable; (6) because the speed of the air flow and the way of the airflow are different, the preserved quantity at the pharyngeal position is a little less when dry-powder agent is used to be sucked.

Description

A kind of oval Diskus

(1) technical field:

This utility model relates to the Diskus tool that is used for pulmonary administration, especially a kind of oval Diskus.

(2) background technology:

Powder spray (powder inhalation, PI) be meant one or more medicine, enter respiratory tract with dry powder form after special doser administration, a kind of drug-supplying system of performance whole body or local action has targeting, efficient, quick-acting, characteristics such as toxic and side effects is little.According to the difference of medicine-feeding part, can be divided into per nasal and use (lung suction) powder spray with powder spray with through the oral cavity.

At present, the dust cloud inhalation dosage form that pulmonary discharges generally is divided into three kinds, promptly metered dose inhalation aerosol (Metered Dose Inhaler, MDI), atomized inhalation (Nebulizer) and solubility Foradil Aerolizer formoterol fumarate (Dry Powder Inhaler, DPI).

Because the medicine in the powder spray is to absorb by the abundant blood capillary of pulmonary to enter blood, so than oral and injection type, absorption area is bigger, infiltration rate is faster, thereby, have following characteristics: 1. do not have the gastrointestinal tract Degradation as the respiratory mucosa absorbable preparation; 2. there is not liver first-pass effect; 3. drug absorption is rapid, and is rapid-action after the administration; 4. the bioavailability of macromolecular drug can be by the improve that should be used for of absorption enhancer or additive method; 5. small-molecule drug is particularly useful for respiratory tract and directly sucks or spray into administration: 6. directly enter the body circulation after the drug absorption, reach the purpose of whole body therapeutic; 7. can be used for the big medicine of water solublity that gastrointestinal tract is difficult to absorb; 8. good patient compliance is specially adapted to the patient that former need carry out the long term injections treatment; 9. play the medicine of local action, dosage obviously reduces, and toxic and side effects is little.

Certainly, the suction-type pulmonary administration also has some unique technique difficult points, absorbs because powder spray is a respiratory system by the people, and human body vesicular breathing road always has bifurcated 23 times, and surface area has 70 ~ 80 square metres approximately, and the film blood vessel of alveolar also is a monofilm.If dry powder sucks the medicine that absorbs by pulmonary, molecular weight is big just is difficult to absorb, and the powder diameter is greater than 5 ~ 6 μ m, also be difficult to absorb, the medicine that protein binding rate is low also is difficult to absorb, if this class medicine of insulin reaches the particle diameter of 2 μ m, just can directly absorb by pulmonary.

Medicine is to enter in the body with the form output of aerosol (aerosol) and with breathing by inhalation apparatus when sucking treatment.Aerosol has huge contact surface, helps medicine and contacts with airway surface and play a role, but have cohesion simultaneously.Aerocolloidal flowability depends on that the external world gives its initial velocity, and its settlement action is followed the Stoke law substantially, and promptly sedimentation velocity is directly proportional with granular mass.The motion mode of dry-powder medicament in lung mainly contains following 3 kinds of (1) disperse campaigns (diffusion), or is called the Brownian motion, and be relevant with the microparticle size with the time, and irrelevant with the particulate density of medicine mist; (2) gravitational motion (gravitational transport) or be referred to as subsiding movement (sedimentation), all relevant with the size and the density of time, microparticle; The size of (3) inertia motion (inertial transport) gettering rate, microparticle is relevant with density.Therefore since the difference of the size of the characteristics of conveyer device, drug particles, form, molecular weight, electric charge, moisture absorption etc. suck medicine and can produce different clinical effects.With regard to granular size, the drug particles of diameter 1～5 μ m is the most suitable, be referred to as to suck granule, greater than the granule of 5 μ m then the overwhelming majority be trapped within pars oralis pharyngis, finally enter in the body through swallowing, though and can reach lower respiratory tract less than the granule of 0.5 μ m, 90% microgranule excretes with expiration again when moisture is breathed.

Therefore, the pulmonary administration mode depends on administration apparatus to a great extent, it is good that ideal Diskus should possess the medicine of conveying usefulness, output dose and microparticle constant magnitude, can reach the influence that suitable pulmonary drug deposition is not subjected to inspiratory flow rate, drug distribution in the good lung is arranged, and pars oralis pharyngis medicine retention amount is less.Convenient to use, be the multiple dose device.Characteristics such as the harmony that sucks technology is required low, it is wide to be suitable for the range of age, lightly is easy to carry about with one, and does not contain the additive that patient or environment are unfavorable for, need not maintenance, economical and practical.It is that a kind of new device of inhaler internal gear modular design in 200720099545.8 disclosed a kind of powder inhalers solves the problem that prior art exists that this utility model utilizes the patent No..

(3) utility model content:

The purpose of this utility model is to design a kind of oval Diskus, this device relies on by user's turn knob, drive the medicine paper tinsel of the incompatible transmission given dose of the gear train dry-powder medicament of device inside, the user begins to be undertaken air-breathing by the inhaler suction nozzle, the dry-powder medicament of given dose is sucked pulmonary, thereby reach therapeutic effect.

The technical solution of the utility model: a kind of oval Diskus, comprise the combination of housing and inhaler internal gear, it is characterized in that being equipped with in the housing inhaler suction nozzle and knob; Wherein said inhaler suction nozzle is connected with knob; Said knob makes up to be by knob center pillar and inhaler internal gear and is in transmission connection.

Above-mentioned said knob is spiral type or bar knob.

Above-mentioned said knob is connected with the counting display unit.

Above-mentioned said inhaler suction nozzle is connected with suction nozzle protection enclosing cover.

Above-mentioned said suction nozzle protection enclosing cover is connected with housing according to positioner.

Above-mentioned said housing has the lanyard of being place and sign outward.

Work process of the present utility model is: (1) opens the Diskus enclosing cover: by sign direction turn knob one lattice, can hear " click " sound, back knob center pillar and internal gear produce reasonable transmission, open the medicine dry powder of a dosage; (2) prepare to suck: both hands are arrested suction apparatus, and suction nozzle exposes, in order to sucking; (3) suck: the user aims at suction nozzle, keeps the inhaler balance and suction nozzle is contained in the inlet, steadily breathes suction nozzle is put into mouth, sucks medicine as far as possible, and is fully air-breathing; (4) close: behind abundant air-breathing finishing, as next suction of need, above-mentioned institute repeats to get final product in steps when needed; (5) time spent not, the inhaler suction nozzle should place in the enclosing cover, plays the effect of protection inhaler; (6) wherein count display unit and show residual drug, with shown in red, warning residue dosage is few when using last dosage and be 5～0.

Above-mentioned described step (1) must guarantee as far as possible: acutely do not rock inhaler; Do not exhale facing to the inhaler suction nozzle; Guarantee that you press the inhaler slide bar when needs use medicine; Using dosage please be followed the doctor's advice.

The medicine of the opened bubble-cap dosage of inhaler during above-mentioned described step (2), and carry out and inhale preceding all preparations of medicine, the user only need suck medicine and get final product in the existing corresponding demonstration of counting display unit this moment.

Above-mentioned described step (3) is please taken out inhaler after sucking from mouth, be sure not to go into from snuffing.

Operation principle of the present utility model is: the dry powder inhaler device that the utility model discloses a kind of oval pulmonary administration, this device relies on the strength that is produced by user's turn knob, drive the medicine paper tinsel of the incompatible transmission given dose of the gear train dry-powder medicament of device inside, promptly act on the aggregate motion of knob interlock internal gear by external force, the bubble-cap of medicine chaff is torn one by one, user this moment can suck medicated powder in the bubble-cap of opening by suction nozzle, make the dry-powder medicament of setting dosage suck pulmonary, thereby reach therapeutic effect.Structure of the present utility model has strengthened the air velocity in the dry powder suction (DPI) and has sucked dry powder particle more fully so that suck air-flow.Of the present utility model by fixed gear combination, reach the purpose that transmits the medicine paper tinsel.

This utility model is applicable to that the treatment field of inhaler includes but not limited to: the disorder of obstacle, digestive tract or the digestive system of respiratory system obstacle, muscle or neuromuscular systems such as asthma, COPD, the obstacle of cardio-cerebrovascular, imbalance, reproduction or the sexual dysfunction of hormonal system, neural obstacle, anaphylactic disease, psychiatric department disease, infection, pain.

This utility model is applicable to and includes but not limited to the medicine selected from following: zanamivir, codeine, paramorphane, Ergotamine, sweet smell is the slave too, morphine, diltiazem, cromoglycate, cephalosporins, penicillin, streptomycin, sulfonamides, tetracycline, beclometasone, dipropionate, Fluticasone Propionate, flunisolide, fluticasone, budesonide, budesonide, salbutamol sulfate, the ephedrine class, adrenin, fenoterol, formoterol, risperidone, nifedipine, sulindac, tibolone, stavudine, Carclura, rapamycin, glipizide, triamcinolone acetonide, alprazolam, midazolam, romilar, indinavir, Nateglinide, different third (nor-) epinephrine, two antelope propyloxy phenyl ethylaminoethanols, phenylpropanolamine HC1, adjoin Boot sieve acetate, cortisone, hydrocortisone or andrographolide, aminophylline, the choline theophylline, tiotropium bromide, tetanus toxoid, calcitonin, insulin or glucagon, or salt, vinegar, or its chemical compound alone or in combination.

This utility model is applicable to and includes but not limited to the biological product selected from following: vaccine (make immune serum with virus, rickettsia, comprise antitoxin, antibiotic and antiviral serum) as: various blood products, organize goods, nonspecific immunity goods and little ecological goods etc.Human albumin, human, interleukin, interferon, thymosin and cereobiogen, house Rayleigh, multi-joint multivalence goods or mix preparations such as oxytocin, somatostatin, Sermorelin, octreotide, leuprorelin and various cytokines.

Superiority of the present utility model is: (1) this inhaler can repeat to load the medicine paper tinsel and use, and convenient counting as needs, can take out the medicine paper tinsel or load again and reuse; (2) Diskus have easy to carry, use quick, processing ease; (3) do not contain CFC fluoroalkane hydro carbons, can use pure medicine; (4) need not keep in repair; (5) initiatively suck the kinetic energy dispersion medicine microgranule of air by user, match with the flow velocity of powder particles and the inspiratory flow rate of user, and medicine is exported with the dry powder particle form, therefore rapid variation can not take place because of the variation of time and distance in the size of dry-powder medicament microparticle after leaving suction apparatus, and dry powder particle is more stable; (6) because gas velocity and streamer mode different, pars oralis pharyngis retention amount is less when using dry powder doses to suck; (7) compact conformation of the present utility model has strengthened the air velocity among the DPI and has sucked dry powder particle more fully so that suck air-flow.

(4) description of drawings:

Fig. 1 is the structural representation of the related a kind of oval Diskus of this utility model.

Fig. 2 is first side schematic view of Fig. 1.

Fig. 3 is second side schematic view of Fig. 1.

Fig. 4 is the 3rd side schematic view of Fig. 1.

Fig. 5 is the 4th side schematic view of Fig. 1.

Wherein: 1.1 is DPI knob center pillar, and 1 is spiral type or bar knob, and 2 is housing, and 3 are the counting display unit, 4 suction nozzle enclosing covers, and 5 is suction nozzle, and 6 is positioner, and 7 are sign, and 8 for being the lanyard place.

(5) specific embodiment:

Embodiment: a kind of oval Diskus (seeing Fig. 1-5), comprise the combination of housing 2 and inhaler internal gear, it is characterized in that being equipped with in the housing 2 inhaler suction nozzle 5 and knob 1; Wherein said inhaler suction nozzle 5 is connected with knob 1; Said knob 1 makes up to be with the inhaler internal gear by knob center pillar 1.1 and is in transmission connection.

Above-mentioned said knob 1 is a spiral type.

Above-mentioned said knob 1 is connected with counting display unit 3.

Above-mentioned said inhaler suction nozzle is connected with suction nozzle protection enclosing cover 4.

Above-mentioned said suction nozzle protection enclosing cover 4 is connected with housing 2 according to positioner 6.

Above-mentioned said housing has the lanyard of being place 8 and sign 7 outward.

Claims (6)

1, a kind of oval Diskus comprises the combination of housing and inhaler internal gear, it is characterized in that being equipped with in the housing inhaler suction nozzle and knob; Wherein said inhaler suction nozzle is connected with knob; Said knob makes up to be by knob center pillar and inhaler internal gear and is in transmission connection.

2,, it is characterized in that said knob is spiral type or bar knob according to claim 1 oval Diskus.

3,, it is characterized in that said knob is connected with the counting display unit according to claim 1 or 2 one kind of oval Diskus.

4,, it is characterized in that said inhaler suction nozzle is connected with suction nozzle protection enclosing cover according to claim 1 oval Diskus.

5,, it is characterized in that said suction nozzle protection enclosing cover is connected with housing according to positioner according to claim 1 oval Diskus.

6,, it is characterized in that said housing has the lanyard of being place and sign outward according to claim 1 oval Diskus.

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