CN101450145B - Traditional Chinese medicine for treating malignancy and preparation method thereof - Google Patents
Traditional Chinese medicine for treating malignancy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an anti malignant tumor traditional Chinese medicine preparation and preparation method thereof. The main components and weight ratio of the medicine is: arsenic 0.065-2.4 parts, toad venom 2-24 parts, euphorbia 50-480 parts, monkshood head 40-400 parts, nux vomica 20-258 parts, henbane seed 20-240 parts, coptis 30-350 parts and licorice 30-350 parts. The preparation method comprises: 1, grinding the arsenic with water into fine powder; 2, extracting the euphorbia, toad venom, monkshood head, nux vomica, henbane seed, leech, coptis and licorice to achieve extract. 3, steaming and boiling menispermaceae and otolhum pseudoscinaenae to achieve another extract, adding the extract from step 2, stirring uniformly to achieve fine powder; 4, stirring uniformly with the fine powder from the step 1, to achieve powder preparation; 5, adding auxiliary materials into the powder preparation, mixing uniformly and making into capsules and tablets. The medicine in the invention has obvious effect for reducing malignant tumor, regulating immune function, achieves the advantages of good curative effect and little side-effect to human body.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method, specifically refer to a kind of anti-malignant tumor Chinese medicine preparation and preparation method.
Background technology:
Chinese medicine has certain advantage aspect the treatment malignant tumor clinically at present; can regulate, strengthen method strengthening vital QI to eliminate pathogenic factors such as body immunity, treating the poisonous disease with poisonous drugs, eliminating stagnation silt by feelings will; eliminate malignant tumor; and avoid putting, during chemotherapy to the side effect of normal body cell, receive better curative effect.
Press the Chinese medical discrimination theory, the main diseases of malignant tumor because of that mechanism is that healthy energy is lost is empty, pyretic toxicity pents up, due to the meridian stasis resistance, yin and yang imbalance, spiritual disorder of emotion, qi depression to blood stasis, phlegm-damp cohesion.Treatment should reach treating both the principal and the secondary aspects of a disease at the same time with immunomodulating, dredging the meridian, regulating qi-flowing for activating stagnancy, blood circulation promoting and blood stasis dispelling, treating the poisonous disease with poisonous drugs, eliminating stagnation softening the hard mass.At present, also use the Chinese medicine of some treatment malignant tumor on the market, but Chinese medicine majorities of these treatment malignant tumor are preventative or complementary, to the lethality of malignant cell a little less than, what make malignant tumor dwindles that effect is not obvious, therapeutic effect is poor.Medical research achievement in recent years shows, Chinese medicine arsenicum and arsenic preparation are to the treatment of malignant tumor, particularly leukemic treatment is had definite curative effect, arsenic trioxide when low concentration main interference cell the passing through of S phase, during high concentration then selectivity lure S phase apoptosis.To the marrow leukaemia cell apoptosis is the far-end that starts from the waterfall type kinase, and the adenosine phosphate polymerase cracking by poly realizes.Apoptosis to hepatoma carcinoma cell has characteristic to change, and cell membrane is complete, the chromatin pyknosis, and karyorrhexis transfers the corpusculum of dying to form.But arsenicum is very toxic, the injection systems that adopt when using arsenicum treatment malignant tumor at present more, and necessary strict control consumption is pressed the configuration of scientific technology method when therefore oral.
Summary of the invention:
The object of the present invention is to provide a kind of make malignant tumor dwindle effect obviously, human body takes the Chinese medicine preparation that side effect is little, therapeutic effect is good.Another purpose of the present invention is to provide a kind of preparation method of anti-malignant tumor Chinese medicine preparation.
The present invention seeks to realize like this, its primary raw material medicine and weight proportion are as follows: arsenicum 0.065-2.4 part, Venenum Bufonis 2-24 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 50-480 part, Radix Aconiti 40-400 part, Semen Strychni 20-280 part, Semen Hyoscyami 20-240 part, Rhizoma Coptidis 30-350 part, Radix Glycyrrhizae 30-350 part.
Its crude drug and weight ratio also can be as follows: arsenicum 0.065-2 part, Venenum Bufonis 2-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 70-400 part, Radix Aconiti 50-350 part, Semen Strychni 20-200 part, Semen Hyoscyami 20-200 part, Rhizoma Coptidis 40-300 part, Radix Glycyrrhizae 50-300 part.
Optimum weight proportioning of the present invention is as follows: 0.1 part of arsenicum, 2 parts of Venenum Bufoniss, 70 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 50 parts of Radix Aconitis, 40 parts of Semen Strychni, 30 parts of Semen Hyoscyamis, 50 parts of Rhizoma Coptidis, 50 parts in Radix Glycyrrhizae.
The present invention also comprises one of following crude drug or combination: Radix Stephaniae Tetrandrae 30-350 part, Asteriscus Pseudosciaenae 30-350 part, Lignum Sappan 30-350 part, Hirudo 30-350 part, Rhizoma Curcumae 30-350 part, Radix Rehmanniae 30-350 part.
Arsenicum in the side, Venenum Bufonis, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) are the monarch drug group, arsenicum suffering, acid, heat, big poison, rob the expectorant preventing the attack (or recurrence) of malaria, detoxifcation is warded off dirty, can change the existence temperature of tumor cell, cause the malignant tumor living environment to change, thereby suppress the kinds of tumor cells growth, marrow leukaemia cell is had the obvious suppression effect.Venenum Bufonis suffering, temperature, poisonous, reducing swelling and alleviating pain has leukocyte increasing, improves immunologic function, stronger antitumor action.Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) hardship, suffering, flat, poisonous are gone into lung, spleen, Liver Channel, and the removing mass parasite killing has stronger antiinflammatory, antibiotic, antivirus action.Stellera chamaejasme L. alcohol extract and water extract can effectively suppress kinds of tumor cells.Use arsenicum heat to storm and capture victory in the side, the secondary attack of Venenum Bufonis warming middle-JIAO, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) is got rid of evils gently, and above-mentioned three medicines are the monarch drug group, and big heat is attacked big poison, eliminating evilly consolidates, immunomodulating, hard masses softening and resolving.
With Radix Aconiti, Semen Strychni, Semen Hyoscyami, Hirudo is the ministerial drug group.Radix Aconiti can dredging the meridian, give birth to that Qinghua is turbid, activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain, and stronger antitumor action is arranged.Modern medicine proves that aconitine has tangible local anesthesia effect, and the retardation of mice sciatic nerve-trunk is equivalent to 31 times of cocaine, and the effect of Cavia porcellus subcutaneous injection infiltration anesthesia is equivalent to 400 times of cocaines, and the patient does not have dependency.Semen Strychni has antiinflammatory, antitumor action, strychnine energy stimulating central nervous system, microcirculation improvement, blood flow increasing.The Semen Hyoscyami relieving spasm to stop pain improves blood circulation, strengthens metabolic capacity, share with Radix Aconiti and can improve analgesic effect.Radix Aconiti can replace with Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), and consumption reduces by half.The Hirudo removing blood stasis silt power of dispelling is strong, the meridian dredging, subduing inflammation.More than four flavors for the ministerial drug group, dredging the meridian, blood circulation promoting and blood stasis dispelling, it is turbid to give birth to Qinghua, relieving spasm to stop pain reaches the purpose of strengthening vital QI to eliminate pathogenic factors.
Assistant is with Rhizoma Coptidis, Radix Stephaniae Tetrandrae, Asteriscus Pseudosciaenae, Lignum Sappan.Antibiotic, the antiviral of Rhizoma Coptidis, heat-clearing and toxic substances removing.Radix Stephaniae Tetrandrae has blood flow increasing, the inducing diuresis to remove edema effect, and effectively the antagonism aconitine is to the influence of arrhythmia.Asteriscus Pseudosciaenae has treating stranguria Detoxication, can separate the poison of arsenicum, arsenic the accumulating in vivo of degrading fast.Lignum Sappan has softening the hard mass de-sludging, blood circulation promoting and blood stasis dispelling, antitumor action, can effectively suppress arsenicum to cardiovascular influence, reduces coronary resistance.More than four flavors for the adjuvant drug group, heat-clearing and toxic substances removing, the softening the hard mass de-sludging, blood circulation promoting and blood stasis dispelling reaches the purpose of strengthening the body resistance.
With Rhizoma Curcumae, Radix Rehmanniae, Radix Glycyrrhizae is the messenger drug group.Rhizoma Curcumae circulation of qi promoting removing blood stasis protects the liver strong kidney, eliminates arsenicum to lesions of liver and kidney, removing food stagnancy pain relieving again, and thermal detoxification is separated in the diuresis of Radix Rehmanniae heart tonifying, and the raising immunity function is arranged; The Radix Glycyrrhizae heat-clearing and toxic substances removing has and has slow.More than three flavors for the messenger drug group, the toxicity of separating all medicines is in harmonious proportion hundred medicines, integration one improves curative effect.
Monarch of the present invention, minister, assistant, make, interact, respectively execute its effect, when using big cytotoxic drug, to keep the good and eliminate the evil, dialectical executing controlled, detoxify with poison, the gentle property of medicine, this compound Chinese medicine preparation had both satisfied pharmacopeia medication standard, had brought into play arsenicum again, Venenum Bufonis, Semen Strychni, unique curative effect effect of Semen Hyoscyami, hard masses softening and resolving, activating blood circulation to dissipate blood stasis, dredging the meridian, strengthening vital QI to eliminate pathogenic factors, improve immunity, by changing the existence temperature of malignant tumor, cause the variation of malignant tumor living environment, the dissipating blood stasis eliminating stagnation, treating both the principal and the secondary aspects of a disease at the same time, malignant tumor is had the effect of obviously dwindling, the leukaemia is had obvious inhibitory action, therapeutic effect is good.Behind general patient's medication treatment, all can palliate the agonizing sufferings, stimulating appetite, body constitution strengthens, and quantity of leucocyte increases, and promotes life to prolong.
The preparation method of above-mentioned antitumor Chinese medicine preparation may further comprise the steps: 1. get Powdered arsenicum finished product (white, extremely poison, good to eat tasting not), add suitable quantity of water, grind repeatedly, in water, stir by dosage in the side, the float impalpable powder, standby; 2. other medical materials are washed, wherein the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) is a Stellera chamaejasme L., Venenum Bufonis processed with wine, Radix Aconiti hot pressing steam treatment, Semen Strychni stir-baking in sand method detoxification is handled, Hirudo is scalded the processing of drum detoxification with Pulvis Talci, and the Asteriscus Pseudosciaenae calcine is then with medical material natural drying or oven dry such as the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Venenum Bufonis, Radix Aconiti, Semen Strychni, Semen Hyoscyami, Hirudo, Rhizoma Coptidis, Radix Glycyrrhizaes, pulverize and be 100-200 order medicated powder, all medicine mix homogeneously are 75% ethanol extraction 1-3 time with concentration, and extraction time is 24 hours.Filtration, concentrated, dry gets activity extract; 3. Radix Stephaniae Tetrandrae, Asteriscus Pseudosciaenae, Lignum Sappan, Rhizoma Curcumae, Radix Rehmanniae natural drying or oven dry are pulverized and be 100-200 order medicated powder, put into extractor, soaked 3 hours, steaming and decocting for the first time 2.5-3 hour leaches, steaming and decocting for the second time 1.5-2 hour, leach, with the extract of twice filtrate merging, the activity extract that adding step " 2 " obtains stirs, 400 order fine powders are dried, are ground into to filtrate simmer down to density 1.30-1.35 thick paste shape; 4. evenly stir with step 1 alternate polarities fine powder, get powder; 5. powder is added right amount of auxiliary materials, uniform mixing is made capsule, tablet, granule, drop pill with common process.
Adjuvant is meant filler, lubricant.Filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose, and lubricant comprises micropowder silica gel, one or more in Pulvis Talci, the magnesium stearate.
The present invention is through clinical practice for many years, with in various to 60 examples, late malignant tumour patient's treatment is example, total effective rate 85%.Leukemia 18 examples wherein, malignant lymphoma 12 examples, hepatocarcinoma 10 examples, pulmonary carcinoma 20 examples.By cytodiagnosis, blood routine examination, hepatic and renal function is checked, regularly carries out imaging examinations such as rabat, CT, B ultrasonic, takes medicine one more than the course of treatment, three months is a course of treatment, patient's lump of 70% reduces more than 50%, and wherein patient's lump of 40% is eliminated fully, simultaneously, the patient there is preferably QI invigorating, enriches blood, regulates function such as immunity, weak, the alopecia that patient after the prevention chemotherapy is occurred, feel sick and General Symptoms such as leukopenia has and prevents preferably and alleviate effect.
Table 1: tumor is dwindled situation
| Name of disease | The example number | Alleviate fully | Part is alleviated | Stable | Worsen |
| Leukemia | 18? | ?7? | ?6? | ?2? | ?3? |
| Malignant lymphoma | 12? | ?8? | ?2? | ?1? | ?1? |
| Hepatocarcinoma | 10? | ?3? | ?2? | ?3? | ?2? |
| Pulmonary carcinoma | 20? | ?6? | ?8? | ?3? | ?3? |
| Amount to | 60? | ?24? | ?18? | ?9? | ?9? |
Efficacy assessment standard:
Alleviate fully: the tumor complete obiteration, keep more than 4 weeks;
Part is alleviated: tumor is dwindled more than 50%, keeps for 4 weeks;
Stable: tumor is dwindled not as good as 50%.Increase and be no more than 25%;
Worsen: tumor increases more than 25%.
Table 2:MTT method detects anti-malignant tumor Chinese medicine to the leukemia K 562 cell inhibitory rate
(X±SD，n＝6)
Annotate: the injection of animal abdominal part is adopted in cisplatin (DDP) experiment.
Table 3:MTT method detects anti-malignant tumor Chinese medicine to the lung cancer A549 cell suppression ratio
(X±SD，n＝6)
Annotate: the injection of animal abdominal part is adopted in cisplatin (DDP) experiment.
Table 4:MTT method detects anti-malignant tumor Chinese medicine to colon cancer CaCo2 cell inhibitory rate
(X±SD，n＝6)
Annotate: the injection of animal abdominal part is adopted in cisplatin (DDP) experiment.
From table 1, table 2, table 3, table 4 as can be seen, this anti-malignant tumor Chinese medicine has obvious inhibitory action and tumor to dwindle effect to tumor, leukemia K 562 cell strain, lung cancer A549 cell strain, colon cancer CaCo2 cell strain there are obvious inhibitory action, and dependence are arranged with dosage.
Table 5:MTT method is to the influence to gastric mucosal cell of the anti-malignant tumor Chinese medicine preparation of different diluted concentrations in DMSO solution and the aqueous solution
| The DMSO solution concentration | Gastric mucosal cell suppression ratio (%) | Concentration of aqueous solution | Gastric mucosal cell suppression ratio (%) |
| Dilute 1000 times | 0.2165? | Dilute 250 times | 0.2316? |
| Dilute 2000 times | 0.1966? | Dilute 500 times | 0.2138? |
| Dilute 4000 times | 0.1884? | Dilute 1000 times | 0.1914? |
| Dilute 8000 times | 0.1713? | Dilute 2000 times | 0.1833? |
Annotate: with the extension rate of former medicine 400mg under different solutions.
As can be seen from Table 5, anti-malignant tumor Chinese medicine preparation of the present invention does not have toxic action substantially to normal gastric mucosal cell.
Table 6 anti-malignant tumor Chinese medicine preparation The acute toxicity tests
Annotate: laboratory animal is 80 of Kunming kind white mice, the cleaning level, and body weight 16-18g is divided into 8 groups immediately, and 10 every group, male and female half and half, the white mice quality certification number 001467.
As can be known from Table 6, i=lgd3-lgd4=1.1004-0.9754=0.1250
Median lethal dose(LD 50) LD
50=lg
-1[1.3502-0.1250 (3.6-0.50)]
＝lg
-1[0.9627]
＝9.1770(g/kg)
Standard error Sx
50=0.0045
LD
5095% fiducial limit=lg
-1(0.9627 ± 1.96 * 0.0445)
＝lg
-1(0.9627±0.0872)
＝7.5076～11.2176(g/kg)
LD
50Average fiducial limit=9.1770 ± 3.6416 (g/kg)
The LD of anti-malignant tumor Chinese medicine preparation
50Be 9.1770 ± 3.6416g/kg, 95% the average credible 7.5076～11.2176g/kg that is limited to.This Chinese medicine preparation has certain toxicity, accumulates period in a medicine drug withdrawal in per 10 days a day, intramuscular injection dimercaptopropanol, BAL 0.1-0.2 gram in vivo in order to prevent arsenic.Removing may remain in intravital drug toxicity, reaches safest degree.Table 6 acute toxicity test is the result show, dosage use in accordance with regulations was to meet human body medication standard fully when this Chinese medicine preparation was taken.
The specific embodiment:
Embodiment 1: get 0.1 part of arsenicum, 2 parts of Venenum Bufoniss, 70 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 50 parts of Radix Aconitis, 40 parts of Semen Strychni, 30 parts of Semen Hyoscyamis, 50 parts of Rhizoma Coptidis, 50 parts in Radix Glycyrrhizae.Get Powdered arsenicum finished product (white, extremely poison, good to eat tasting not), add suitable quantity of water, grind repeatedly, in water, stir by dosage in the side, the float impalpable powder, standby.Other medical materials are washed, wherein the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) is a Stellera chamaejasme L., the Venenum Bufonis processed with wine, Radix Aconiti hot pressing steam treatment, Semen Strychni stir-baking in sand method detoxification is handled, then with medical material natural drying or oven dry such as the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Venenum Bufonis, Radix Aconiti, Semen Strychni, Semen Hyoscyami, Rhizoma Coptidis, Radix Glycyrrhizaes, pulverize and be 100-200 order medicated powder, all medicine mix homogeneously are 75% ethanol extraction 1-3 time with concentration, and extraction time is 24 hours.Filtration, concentrated, dry gets activity extract, and 400 order fine powders are dried, are ground into to filtrate simmer down to density 1.30-1.35 thick paste shape.Evenly stir with the alternate polarities fine powder, get powder.Powder is added right amount of auxiliary materials, make capsule, tablet with common process.Usage every day 3 times, each 800 milligrams, one after each meal, plain boiled water is taken after mixing it with water.
Embodiment 2: get 0.065 part of arsenicum, 2 parts of Venenum Bufoniss, 50 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 40 parts of Radix Aconitis, 20 parts of Semen Strychni, 20 parts of Semen Hyoscyamis, 30 parts of Rhizoma Coptidis, 30 parts of Radixs Stephaniae Tetrandrae, 30 parts of Asteriscus Pseudosciaenaes, 30 parts of Lignum Sappans, 30 parts in Radix Glycyrrhizae.Get Powdered arsenicum finished product (white, extremely poison, good to eat tasting not), add suitable quantity of water, grind repeatedly, in water, stir by dosage in the side, the float impalpable powder, standby.Other medical materials are washed, wherein the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) is a Stellera chamaejasme L., the Venenum Bufonis processed with wine, Radix Aconiti hot pressing steam treatment, Semen Strychni stir-baking in sand method detoxification is handled, then with medical material natural drying or oven dry such as the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Venenum Bufonis, Radix Aconiti, Semen Strychni, Semen Hyoscyami, Rhizoma Coptidis, Radix Glycyrrhizaes, pulverize and be 100-200 order medicated powder, all medicine mix homogeneously are 75% ethanol extraction 1-3 time with concentration, and extraction time is 24 hours.Filtration, concentrated, dry gets activity extract.It is 100-200 order medicated powder that Radix Stephaniae Tetrandrae, Asteriscus Pseudosciaenae, Lignum Sappan natural drying or oven dry are pulverized, put into extractor, soaked 3 hours, steaming and decocting for the first time 2.5-3 hour leaches, steaming and decocting for the second time 1.5-2 hour, leach, the extract with twice filtrate merging stirs, 400 order fine powders are dried, are ground into to filtrate simmer down to density 1.30-1.35 thick paste shape.Evenly stir with the alternate polarities fine powder, get powder.Powder is added right amount of auxiliary materials, make capsule, tablet with common process.Usage every day 3 times, each 800 milligrams, one after each meal, plain boiled water is taken after mixing it with water.
Embodiment 3: get 2.4 parts of arsenicum, 24 parts of Venenum Bufoniss, 480 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 400 parts of Radix Aconitis, 280 parts of Semen Strychni, 240 parts of Semen Hyoscyamis, 350 parts of Rhizoma Coptidis, 350 parts of Radixs Stephaniae Tetrandrae, 350 parts of Asteriscus Pseudosciaenaes, 350 parts of Lignum Sappans, 350 parts of Hirudos, 350 parts of Rhizoma Curcumae, 350 parts of Radix Rehmanniae, 350 parts in Radix Glycyrrhizae.Get Powdered arsenicum finished product (white, extremely poison, good to eat tasting not), add suitable quantity of water, grind repeatedly, in water, stir by dosage in the side, the float impalpable powder, standby.Other medical materials are washed, wherein the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) is a Stellera chamaejasme L., the Venenum Bufonis processed with wine, Radix Aconiti hot pressing steam treatment, Semen Strychni stir-baking in sand method detoxification is handled, Hirudo is scalded the processing of drum detoxification with Pulvis Talci, then with medical material natural drying or oven dry such as the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Venenum Bufonis, Radix Aconiti, Semen Strychni, Semen Hyoscyami, Hirudo, Rhizoma Coptidis, Radix Glycyrrhizaes, pulverize and be 100-200 order medicated powder, all medicine mix homogeneously, with concentration is 75% ethanol extraction 1-3 time, and extraction time is 24 hours.Filtration, concentrated, dry gets activity extract.It is 100-200 order medicated powder that Radix Stephaniae Tetrandrae, Asteriscus Pseudosciaenae, Lignum Sappan, Rhizoma Curcumae, Radix Rehmanniae natural drying or oven dry are pulverized, put into extractor, soaked 3 hours, steaming and decocting for the first time 2.5-3 hour leaches, steaming and decocting for the second time 1.5-2 hour, leach, the extract of twice filtrate merging is stirred, and 400 order fine powders are dried, are ground into to filtrate simmer down to density 1.30-1.35 thick paste shape.Evenly stir with the alternate polarities fine powder, get powder.Powder is added right amount of auxiliary materials, make capsule, tablet with common process.Usage every day 3 times, each 800 milligrams, one after each meal, plain boiled water is taken after mixing it with water.
1. patient, the man, 49 years old, because of the recurrent cough, sputum mixed with blood was surplus January, got pulmonary's biopsy through lung CT and bronchial microscope, was diagnosed as the lower-left lung central type squamous cell carcinoma, took medicine each 800 milligrams, every day 3 times, checked the lump complete obiteration after four months.
2. patient, man, 46 years old, suffered from hepatitis b cirrhosis 3 years, lower limbs edema, abdominal distention, hepatalgia, through CT examination, leftlobe of liver 3.2cm * 2.9cm size low-density lump, sampling biopsy inspection is a primary hepatocarcinoma, the back patient's hepatalgia of taking medicine alleviates, after taking medicine 4 months continuously, lump disappears, and alpha-fetoprotein (AFP value) returns to normal value.
3. patient, the woman, 38 years old, right rib twinge, weak, two lower limb Mild edema, through CT examination, the visible 4.1cm of right lobe of liver * 3.3cm size lump, sampling biopsy inspection is a primary hepatocarcinoma, take medicine each 800 milligrams, every day three times, check the lump complete obiteration after four months.
Claims (6)
1. anti-malignant tumor Chinese medicine preparation, it is characterized in that: its primary raw material medicine and weight proportion are as follows: arsenicum 0.065-2.4 part, Venenum Bufonis 2-24 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 50-480 part, Radix Aconiti 40-400 part, Semen Strychni 20-280 part, Semen Hyoscyami 20-240 part, Rhizoma Coptidis 30-350 part, Radix Glycyrrhizae 30-350 part.
2. anti-malignant tumor Chinese medicine preparation according to claim 1, it is characterized in that: its crude drug and weight ratio are as follows: arsenicum 0.065-2 part, Venenum Bufonis 2-20 part, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 70-400 part, Radix Aconiti 50-350 part, Semen Strychni 20-200 part, Semen Hyoscyami 20-200 part, Rhizoma Coptidis 40-300 part, Radix Glycyrrhizae 50-300 part.
3. anti-malignant tumor Chinese medicine preparation according to claim 1 is characterized in that: its crude drug and weight ratio are as follows: 0.1 part of arsenicum, 2 parts of Venenum Bufoniss, 70 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 50 parts of Radix Aconitis, 40 parts of Semen Strychni, 30 parts of Semen Hyoscyamis, 50 parts of Rhizoma Coptidis, 50 parts in Radix Glycyrrhizae.
4. anti-malignant tumor Chinese medicine preparation according to claim 1 is characterized in that: also comprise one of following crude drug or its combination: Radix Stephaniae Tetrandrae 30-350 part, Asteriscus Pseudosciaenae 30-350 part, Lignum Sappan 30-350 part, Hirudo 30-350 part, Rhizoma Curcumae 30-350 part, Radix Rehmanniae 30-350 part.
5. according to claim 1,2,3 or 4 described anti-malignant tumor Chinese medicine preparation, it is characterized in that: it is powder, capsule, tablet, granule, drop pill.
6. method for preparing claim 4 anti-malignant tumor Chinese medicine preparation is characterized in that: comprise the steps: that 1. get Powdered arsenicum, add suitable quantity of water, grind repeatedly, in water, stir by dosage in the side, the float impalpable powder, standby; 2. other medical materials are washed, wherein the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) is a Stellera chamaejasme L., the Venenum Bufonis processed with wine, Radix Aconiti hot pressing steam treatment, Semen Strychni stir-baking in sand method detoxification is handled, Hirudo is scalded the processing of drum detoxification with Pulvis Talci, the Asteriscus Pseudosciaenae calcine, then with the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Venenum Bufonis, Radix Aconiti, Semen Strychni, Semen Hyoscyami, Hirudo, Rhizoma Coptidis, licorice medicinal materials natural drying or oven dry, pulverize and be 100-200 order medicated powder, all medicine mix homogeneously, with concentration is 75% ethanol extraction 1-3 time, extraction time is 24 hours, and filtration, concentrated, dry gets activity extract; 3. Radix Stephaniae Tetrandrae, Asteriscus Pseudosciaenae, Lignum Sappan, Rhizoma Curcumae, Radix Rehmanniae natural drying or oven dry are pulverized and be 100-200 order medicated powder, put into extractor, soaked 3 hours, steaming and decocting for the first time 2.5-3 hour leaches, steaming and decocting for the second time 1.5-2 hour, leach, with the extract of twice filtrate merging, the activity extract that adding step 2 obtains stirs, 400 order fine powders are dried, are ground into to filtrate simmer down to density 1.30-1.35 thick paste shape; 4. evenly stir with the standby arsenicum impalpable powder of step 1, get powder; 5. powder is added right amount of auxiliary materials, make capsule, tablet, granule, drop pill with common process.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101856425B (en) * | 2010-06-04 | 2012-01-25 | 王和鸣 | Externally applied medicine for alleviating cancer pain and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113790A (en) * | 1994-05-27 | 1995-12-27 | 周炜 | Anti-cancer Chinese drug-Xiaoliujing capsule |
| CN1204521A (en) * | 1997-07-08 | 1999-01-13 | 孙贤华 | Tumour eliminating and analgesic adhesive plaster and its preparation method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113790A (en) * | 1994-05-27 | 1995-12-27 | 周炜 | Anti-cancer Chinese drug-Xiaoliujing capsule |
| CN1204521A (en) * | 1997-07-08 | 1999-01-13 | 孙贤华 | Tumour eliminating and analgesic adhesive plaster and its preparation method |
Non-Patent Citations (3)
| Title |
|---|
| 何赛萍.中药抗肿瘤研究思路.《浙江中医学院学报》.2001,第25卷(第4期),61-62. * |
| 周宜强.攻毒、排毒、解毒在治疗恶性肿瘤中的运用.《世界中医药》.2007,第2卷(第4期),200-203. * |
| 陈顺达.中西医结合治疗癌症的体会.《中国中医基础医学杂志》.2002,第8卷(第8期),55. * |
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