CN101450077B - Preparation method of external natural aluminosilicate emergency life-saving hemostatic - Google Patents
Preparation method of external natural aluminosilicate emergency life-saving hemostatic Download PDFInfo
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- CN101450077B CN101450077B CN2009100952738A CN200910095273A CN101450077B CN 101450077 B CN101450077 B CN 101450077B CN 2009100952738 A CN2009100952738 A CN 2009100952738A CN 200910095273 A CN200910095273 A CN 200910095273A CN 101450077 B CN101450077 B CN 101450077B
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- 229910000323 aluminium silicate Inorganic materials 0.000 title claims abstract description 18
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims description 13
- 230000002439 hemostatic effect Effects 0.000 title claims description 7
- 210000004369 blood Anatomy 0.000 claims abstract description 31
- 239000008280 blood Substances 0.000 claims abstract description 31
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 210000002381 plasma Anatomy 0.000 claims abstract description 19
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 11
- 239000011707 mineral Substances 0.000 claims abstract description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052814 silicon oxide Inorganic materials 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000292 calcium oxide Substances 0.000 claims abstract description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 3
- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910001950 potassium oxide Inorganic materials 0.000 claims abstract description 3
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910001948 sodium oxide Inorganic materials 0.000 claims abstract description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims abstract description 3
- 230000000025 haemostatic effect Effects 0.000 claims description 29
- 229940030225 antihemorrhagics Drugs 0.000 claims description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 11
- 239000011575 calcium Substances 0.000 claims description 11
- 229910052791 calcium Inorganic materials 0.000 claims description 11
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 229910052680 mordenite Inorganic materials 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
- 238000010298 pulverizing process Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 2
- 230000015271 coagulation Effects 0.000 claims description 2
- 238000005345 coagulation Methods 0.000 claims description 2
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 2
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 7
- 239000004411 aluminium Substances 0.000 claims 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 7
- 229910052782 aluminium Inorganic materials 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052710 silicon Inorganic materials 0.000 claims 7
- 239000010703 silicon Substances 0.000 claims 7
- 239000002874 hemostatic agent Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 abstract 2
- 208000032843 Hemorrhage Diseases 0.000 description 12
- 229910001579 aluminosilicate mineral Inorganic materials 0.000 description 10
- 239000004927 clay Substances 0.000 description 10
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000023555 blood coagulation Effects 0.000 description 6
- 230000023597 hemostasis Effects 0.000 description 4
- 206010053567 Coagulopathies Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000035602 clotting Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 229910021536 Zeolite Inorganic materials 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000010457 zeolite Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000009306 yunnan baiyao Substances 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A external applied natural aluminosilicates urgency life-saving hemostat utilizes natural aluminosilicates mineral as raw material. The main components of the natural aluminosilicate are: silicon oxide, titanium oxide, aluminium oxide, iron oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide; in which, the total content of silicon oxide and aluminium oxide is more than 70%. The method is characterized in: processing the natural aluminosilicates mineral by blood plasma or whole blood to obtain aluminosilicates urgency life-saving hemostat; it achieves the advantages of simple process and better effect than Quikclot hemostat, and can be applied in different medical accasions.
Description
Technical field
The present invention relates to a kind of preparation method of external natural aluminosilicate emergency life-saving hemostatic.
Background technology
Emergency haemostatic is an emerging research field in the world.Emergency haemostatic is primarily aimed at the outer damaging the spleen and stomach emergency that The blood streamed down and develops.(3 minutes) just can control the emergency as aorta is bled in a short period of time, for further medical treatment tries to gain time precious to one.
Ministry of Public Health statistics according to 2007, annual all kinds of injuries take place about 200,000,000 person-times, because of about 700,000-750,000 people of injury death toll such as war, vehicle accident, major natural disasters, severe loss of blood is the biggest factor that causes died of wounds, and about 67% people dies from uncontrollable losing blood.If hinder several Yuans after wound 1～3 hour obtaining treatment, hemorrhage being effectively controlled, dead people will reduce greatly, rescue the wounded and divide six First aid procedures, be respectively hemostasis, will fix, wrapping, ventilation, carrying and basic life support.Wherein hemostasis is a step at first, is the key of rescuing life.
So far, domesticly be used for, the emergency haemostatic product of severe bleeding is few, hemorrhage commonly used has tourniquet, gauze and YUNNAN BAIYAO, they in, the quick-acting haemostatic powder effect of severe bleeding is limited.Therefore research is used for the quick hemostasis agent of urgent rescue, in can saving, severe bleeding patient life.Quick hemostasis agent is used for army, police, fire fighter, first-aid personnel, medical personnel and domestic hemostasis first aid, and rescue of battlefield etc., also can play a role at vital emergent event such as earthquake, blast mine accident etc.Caused 51151 people's death as the 8.0 grades of violent earthquakes in Wenchuan, Sichuan on the 12nd in May in this year by 10 o'clock on the 22nd May, 288431 people are injured.And in the earthquake relief work, a lot of local hemorrhages are in an emergency, so the blood demand is big especially, and many wounded are lost valuable life because can not in time transfuse blood.The hemorrhage that the present invention developed helps to reduce the injures and deaths situation of spectrum of war, geological disaster.
Studies show that inorganic matter Quikclot haemostatic effect is outstanding, but there is the significantly side effect of suction heat release in Quikclot.The maximum temperature of zeolite haemostatic Quikclot suction heat release can reach about 100 ℃, zoopery shows laboratory animal wound surrounding skin, muscle, nerve, blood vessel and fatty tissue is caused obvious hot injury, thereby further treatment is very inconvenient to the back of stopping blooding.
Chinese patent application number is 200810063282.4,200810122046.5,200810122048.4,200810122045.0, disclose comprise natural zeolite,, attapulgite, bentonite, montorillonite clay external natural mineral emergency haemostatic, solved the side effect of the suction heat release of Quikclot existence, obtained haemostatic effect preferably, but it is little that its haemostatic effect and Quikclot compare advantage, needs better new preparation method of exploitation haemostatic effect.
Summary of the invention
The objective of the invention is to propose a kind of preparation method of natural aluminosilicate mineral hemorrhage, studies show that, handle the natural aluminosilicate mineral, can improve the haemostatic effect of natural aluminosilicate mineral greatly by blood plasma or whole blood.
The present invention proposes the preparation method of external natural carbonate emergency life-saving hemostat, be to utilize the natural aluminosilicate mineral to be raw material, the main component of natural aluminosilicate hydrochlorate is: silicon oxide, titanium oxide, aluminium oxide, ferrum oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide etc.Wherein the total content of silicon oxide and aluminium oxide surpasses 70%.Have regular micropore (0.3～2.0nm) structure, higher specific surface area (30～1000m
2/ g), its composition (silica alumina ratio and various ionic content) can change within the specific limits simultaneously.
The preparation process that the present invention proposes the external natural carbonate emergency life-saving hemostat preparation method is as follows:
1) Ore processing: the natural aluminosilicate mineral are put into Chinese medicine grinder, be ground into grain diameter 1 micron～1 millimeter particles of different sizes;
2) the natural aluminosilicate mineral after will pulverizing at room temperature respectively with blood plasma, whole blood mixing, the mixing ratio of described natural aluminosilicate mineral and blood plasma or whole blood is 1g/0.1～100ml, vacuum drying under 4～38 ℃ of temperature;
3) at last with the hemostatic material deionized water wash behind the above-mentioned vacuum drying, vacuum drying under 4～38 ℃ of temperature obtains natural aluminosilicate mineral emergency haemostatic again.
Raw material natural aluminosilicate mineral of the present invention comprise: bentonite, calcium montmorillonite or modenite.
The mixed proportion of natural aluminosilicate mineral of the present invention and blood plasma, whole blood can make Aluminosilicates mineral and blood plasma, whole blood uniform mixing get final product changing in a big way in principle, can select the scope of 1g: 0.1～100ml.
Used hemocyte, whole blood or the blood plasma of the present invention derives from healthy human body or other have the blood of the healthy animal of nature coagulation function, and the best is the blood of human body or pig.
The present invention has following characteristics:
1, operation is simple, and abundant raw material is cheap and easy to get, and it is convenient to use, and the material haemostatic effect after the improvement is good, and thermal discharge is few.
2, the ratio of control natural aluminosilicate hydrochlorate and blood plasma, whole blood can obviously improve its haemostatic effect, and effect is better than the Quikclot hemorrhage.
3, by with the compound use of other materials, anthemorrhagic performance obviously improves, can be used for different medical applications hemostasis, with other medical materials, medical apparatus and instruments combination, can be made into adhesive bandage, infusion patch, sticking dressing, tablet and capsule core material, operation bag, first-aid kit etc., utilize the performance adsorption antibiotics and the analgesic of absorption to equal wherein simultaneously, can also be as oral drugs; Share with other medicine for external use, thereby obtain better therapeutic.
Description of drawings:
Fig. 1 be natural calcium montorillonite clay used in the present invention and handle through blood plasma, whole blood after the external blood coagulation design sketch of natural calcium montorillonite clay, its empty group is the nature blood coagulation, and matched group is the external blood coagulation experiment (error line is for obtaining according to three groups of data) of natural calcium montorillonite clay and commercialization hemorrhage Quikclot.
Fig. 2 is employed natural mordenite among the present invention and external blood coagulation design sketch after treatment, its empty group is the nature blood coagulation, matched group is natural mordenite and commercialization hemorrhage Quikclot, experimental group is the employed natural mordenite of handling through blood plasma, whole blood among the present invention, and wherein the ratio of modenite and whole blood is 1g/0.1ml (error line is for obtaining according to three groups of data) in last group.
The specific embodiment
Embodiment 1
Respectively a certain amount of natural calcium montorillonite clay, modenite are put into Chinese medicine grinder, the pulverizing time is about 5min, grain diameter after the pulverizing is between 1 micron～1 millimeter, with the natural calcium montorillonite clay after the above-mentioned pulverizing, modenite dry 1h in 100 ℃ of baking ovens.Its haemostatic effect and Quikclot are close, and natural calcium montorillonite clay tcrude ore haemostatic effect figure sees accompanying drawing 1, and modenite tcrude ore haemostatic effect figure sees accompanying drawing 2.
Embodiment 2
Get natural calcium montorillonite clay after a certain amount of pulverizing and blood plasma, whole blood in 1g/1ml ratio uniform mixing at room temperature, dry in 4～38 ℃ of vacuum drying ovens then, grind, with deionized water wash 3 times, again at 4～38 ℃ of ℃ of vacuum dryings.Haemostatic effect was greatly improved after wherein the natural calcium montorillonite clay was handled through blood plasma, whole blood, and the natural calcium montorillonite clay is handled back haemostatic effect figure through blood plasma, whole blood and seen accompanying drawing 1.
Embodiment 3
Get natural mordenite after a certain amount of pulverizing and blood plasma, whole blood in the 1g/1ml ratio, the secondary vacuum baking temperature is 38 ℃, step with reference to embodiment 2, modenite hemorrhage after being improved, be greatly improved through its haemostatic effect of natural mordenite after improving, its haemostatic effect is seen accompanying drawing 2.
Embodiment 4
According to the step of embodiment 3, in the ratio of natural mordenite/whole blood 1g/0.1ml, the secondary vacuum baking temperature is 4～38 ℃, the natural mordenite after being improved, and its haemostatic effect is greatly improved.Its haemostatic effect is seen accompanying drawing 2.
Embodiment 5
Get an amount of hemostatic material of the present invention 38 ℃ of processing 1h in vacuum drying oven, take out a certain amount of pig whole blood (taking from Hangzhou meat processing combine) constant temperature in 25.00 ℃ of constant water bath box simultaneously, treat to begin the blood coagulation experiment behind the pig whole blood temperature stabilization; Get one in test tube, on the quiet blender of having proofreaied and correct rotating speed, angle in advance, measure clotting time,, under this condition, measure the clotting time of hemostatic material then to determine the nature clotting time.
Claims (4)
1. the preparation method of an external natural aluminosilicate emergency haemostatic, be to utilize natural silicon aluminium acid salt mineral to be raw material, the main component of natural silicon aluminium acid salt mineral is: silicon oxide, titanium oxide, aluminium oxide, ferrum oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide, wherein the total content of silicon oxide and aluminium oxide surpasses 70%, and described natural silicon aluminium acid salt mineral are natural mordenite, calcium montmorillonite, bentonitic a kind of; It is characterized in that: utilize blood plasma or whole blood that natural silicon aluminium acid salt mineral are handled, obtain natural aluminosilicate hydrochlorate emergency haemostatic, preparation process is as follows:
1) Ore processing: natural silicon aluminium acid salt mineral are put into Chinese medicine grinder, be ground into grain diameter 1 micron～1 millimeter particles of different sizes;
2) the natural silicon aluminium acid salt mineral after will pulverizing at room temperature respectively with blood plasma, whole blood mixing, the mixing ratio of described natural silicon aluminium acid salt mineral and blood plasma or whole blood is 1g/0.1～100ml, vacuum drying under 4～38 ℃ of temperature;
3) at last with the hemostatic material deionized water wash behind the above-mentioned vacuum drying, vacuum drying under 4～38 ℃ of temperature obtains natural aluminosilicate hydrochlorate emergency haemostatic again.
2. according to the preparation method of claim 1 external natural aluminosilicate emergency haemostatic, it is characterized in that: the mixing ratio of natural aluminosilicate hydrochlorate and blood plasma, whole blood is 1g/ml.
3. according to the preparation method of claim 1 external natural aluminosilicate emergency haemostatic, it is characterized in that: used whole blood or blood plasma derive from healthy human body or other have the blood of the healthy animal of nature coagulation function.
4. according to the preparation method of claim 1 external natural aluminosilicate emergency haemostatic, it is characterized in that: the vacuum drying temperature is 38 ℃.
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| CN2009100952738A CN101450077B (en) | 2009-01-06 | 2009-01-06 | Preparation method of external natural aluminosilicate emergency life-saving hemostatic |
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| CN2009100952738A CN101450077B (en) | 2009-01-06 | 2009-01-06 | Preparation method of external natural aluminosilicate emergency life-saving hemostatic |
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| CN101450077B true CN101450077B (en) | 2011-01-05 |
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| CN102895425B (en) * | 2012-09-06 | 2014-12-24 | 浙江长安仁恒科技股份有限公司 | Bentonite-containing woundplaster |
| RU2522206C1 (en) * | 2012-12-17 | 2014-07-10 | Алексей Вячеславович Дружков | Local hemostatic agent |
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