CN100571712C - The preparation method of externally used ophicalcitum compound emergency life saving hemostatic - Google Patents
The preparation method of externally used ophicalcitum compound emergency life saving hemostatic Download PDFInfo
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- CN100571712C CN100571712C CNB2008101203794A CN200810120379A CN100571712C CN 100571712 C CN100571712 C CN 100571712C CN B2008101203794 A CNB2008101203794 A CN B2008101203794A CN 200810120379 A CN200810120379 A CN 200810120379A CN 100571712 C CN100571712 C CN 100571712C
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- 239000003814 drug Substances 0.000 claims abstract description 9
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- 230000004048 modification Effects 0.000 claims abstract description 6
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- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 4
- 239000002245 particle Substances 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 208000032843 Hemorrhage Diseases 0.000 claims description 21
- 229910021536 Zeolite Inorganic materials 0.000 claims description 9
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 9
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- 238000010298 pulverizing process Methods 0.000 claims description 7
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- 238000006243 chemical reaction Methods 0.000 claims description 3
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- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 claims description 2
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
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- 108090000190 Thrombin Proteins 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
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- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
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Abstract
A kind of externally used ophicalcitum compound emergency life saving hemostatic preparation method, natural Ophicalcitum is ground into certain particle diameter by Chinese medicine grinder, through different Temperature Treatment, carry out the calcium chloride modification again and handle, obtain having the Ophicalcitum composite of efficient hemostatic function with other assisted recombination material mixing.Different medical applications hemostasis be can be used for,, adhesive bandage, infusion patch, sticking dressing, tablet and capsule core material, operation bag, first-aid kit etc. can be made into other medical materials, medical apparatus and instruments combination, can also be as oral drugs; Share with other medicine for external use, thereby obtain better therapeutic.Operation is simple in the present invention, and abundant raw material is cheap and easy to get, and it is convenient to use, and haemostatic effect is good, and thermal discharge is few.
Description
Technical field
The present invention relates to a kind of that be used for the treatment of the hemorrhage emergency haemostatic of the uncontrollable mortality trunk of conventional hemostasis measure and preparation technology, particularly a kind of preparation method of externally used ophicalcitum compound emergency life saving hemostatic.
Background technology
Emergency haemostatic is an emerging research field in the world.Emergency haemostatic is primarily aimed at the outer damaging the spleen and stomach emergency that The blood streamed down and develops.(3 minutes) just can control the emergency as aorta is bled in a short period of time, for further medical treatment tries to gain time precious to one.
Ministry of Public Health statistics according to 2007, annual all kinds of injuries take place about 200,000,000 person-times, because of about 700,000-750,000 people of injury death toll such as war, vehicle accident, major natural disasters, severe loss of blood is the biggest factor that causes died of wounds, and about 67% people dies from uncontrollable losing blood.If hinder several Yuans after wound 1～3 hour obtaining treatment, hemorrhage being effectively controlled, dead people will reduce greatly, rescue the wounded and divide six First aid procedures, be respectively hemostasis, will fix, wrapping, ventilation, carrying and basic life support.Wherein hemostasis is a step at first, is the key of rescuing life.
So far, domesticly be used for, the emergency haemostatic product of severe bleeding is few, hemorrhage commonly used has tourniquet, gauze and YUNNAN BAIYAO, they in, the quick-acting haemostatic powder effect of severe bleeding is limited.Therefore research is used for the quick hemostasis agent of urgent rescue, in can saving, severe bleeding patient life.Quick hemostasis agent is used for army, police, fire fighter, first-aid personnel, medical personnel and domestic hemostasis first aid, and rescue of battlefield etc., also can play a role at vital emergent event such as earthquake, blast mine accident etc.
Studies show that inorganic matter Quikclot haemostatic effect is outstanding, but there is the significantly side effect of suction heat release in Quikclot.The maximum temperature of zeolite haemostatic Quikclot suction heat release can reach about 100 ℃, zoopery shows laboratory animal wound surrounding skin, muscle, nerve, blood vessel and fatty tissue is caused obvious hot injury, thereby further treatment is very inconvenient to the back of stopping blooding.
Natural Ophicalcitum is the stone of stone ophicalcite, contains a large amount of calcium, the carbonate of magnesium, and is mixed with a spot of iron salt, aluminum salt and a spot of acid non-soluble substance.Main effect is a removing stasis to stop bleeding, and treatment hemoptysis, hematemesis, traumatic hemorrhage fall hemorrhages such as pouncing on the pain of injury.Ophicalcitum and complex thereof have hemostatic function efficiently, have better market prospect.So far, do not see to have Ophicalcitum and complex thereof are applied to blood coagulation material, treatment of wounds and create reparation outward and natural zeolite and multi-form combinations such as medical bandage, medical adhesive, be used for the domestic and international patent document report that outer wound is repaired.
Summary of the invention
The objective of the invention is to propose a kind of novel ophicalcitum compound emergency life saving hemostatic and preparation technology thereof.
The present invention proposes a kind of is the preparation technology that primary raw material prepares emergency haemostatic with the Ophicalcitum, natural Ophicalcitum is the stone of stone ophicalcite, contain a large amount of calcium, the carbonate of magnesium, and be mixed with a spot of iron salt, aluminum salt and a spot of acid non-soluble substance.Main effect is a removing stasis to stop bleeding.Treatment hemoptysis, hematemesis, traumatic hemorrhage fall hemorrhages such as pouncing on the pain of injury.
The present invention is ground into certain particle diameter with natural Ophicalcitum by Chinese medicine grinder, has done corresponding improvement simultaneously on the basis of Ophicalcitum, thereby has obtained ophicalcitum compound, has obtained having the Ophicalcitum composite of efficient hemostatic function.Therefore, can be used for different medical applications hemostasis, with other medical materials, medical apparatus and instruments combination, can be made into adhesive bandage, infusion patch, sticking dressing, tablet and capsule core material, operation bag, first-aid kit etc., utilize the performance adsorption antibiotics and the analgesic of absorption to equal wherein simultaneously, can also be as oral drugs; Share with other medicine for external use, thereby obtain better therapeutic.
Externally used ophicalcitum compound emergency life saving hemostatic preparation method provided by the invention, step is as follows:
1) the Ophicalcitum Ore is ground into particles of different sizes by important pulverizer, grain diameter is at 1 micron～1 millimeter.
2) natural zeolite after will pulverizing is through different Temperature Treatment, and heat treatment temperature is 300 ℃, 500 ℃, 700 ℃, 900 ℃ roasting 6h.
3), carry out the calcium chloride modification again and handle with the Ophicalcitum behind the heat treatment.
4) with natural Ophicalcitum and other assisted recombination material mixing.
5) Ophicalcitum and the complex thereof after will pulverizing is 1～24 hour 60～500 ℃ of following processing times of temperature.
Described step 3) calcium chloride modification is handled: with Ophicalcitum behind the heat treatment and concentration is that the calcium chloride solution of 0.1～5.0mol/L mixes by the solid-to-liquid ratio of 1g/5-20ml, room temperature reaction 8h, with deionized water wash three times, and oven dry is residual to there not being water of crystallization, obtains the natural zeolite after the ion exchange.
Other assisted recombination materials of described step 4) are modenite, montorillonite clay etc., and the content of Ophicalcitum is 60-95% in the mixed proportion, and the content of auxiliary material natural zeolite or montorillonite clay is 5-40%.
The action principle of quick hemostasis agent is pure physical property, and institute's thermal discharge obviously reduces in Ophicalcitum and the complex hemorrhage hemostasis thereof, does not have the hot injury to act on to tissue.Ophicalcitum hemorrhage chance blood can absorb rapidly, swelling, not only can accomplish only to absorb moisture and do not absorb thrombin through effects such as physics, chemistry, biologies, reach the enrichment latter's purpose, thereby promote the thrombin activation and adhere to platelet, Ophicalcitum its surface in blood also has negative charge simultaneously, thereby has excited the intrinsic coagulation passage, thereby quickens coagulation process, promote thrombosis, reach the purpose of quick-acting haemostatic powder.Simultaneously have more superior character in some aspects, can become the research of novel hemostatic material to guarantee it.
The present invention has following characteristics:
1, operation is simple, and abundant raw material is cheap and easy to get, and it is convenient to use, and haemostatic effect is good, and thermal discharge is few.
2, its anthemorrhagic performance was improved significantly after Ophicalcitum loaded calcium ion.
3, the heat treatment temperature of control Ophicalcitum rawore stone can obviously improve its haemostatic effect, and traditional Ophicalcitum mineral drug heat treatment temperature surpasses 700 ℃, and its haemostatic effect is general.
4, the Ophicalcitum mineral drug uses the history that has more than one thousand years in China, and biocompatibility issues has been passed through the checking of the countless experiments of forefathers.
5, by with the compound use of other materials, anthemorrhagic performance obviously improves, can be used for different medical applications hemostasis, with other medical materials, medical apparatus and instruments combination, can be made into adhesive bandage, infusion patch, sticking dressing, tablet and capsule core material, operation bag, first-aid kit etc., utilize the performance adsorption antibiotics and the analgesic of absorption to equal wherein simultaneously, can also be as oral drugs; Share with other medicine for external use, thereby obtain better therapeutic.
6, compare with synthetic inorganic mineral hemorrhage Quikclot, Ophicalcitum has advantages such as thermal discharge is few, nature content is abundant; And the price of Quikclot is 150 yuan/bag (100 gram), and the price of Ophicalcitum Ore has tangible price advantage less than 0.50 yuan/100 grams.
Description of drawings:
Fig. 1 by among the present invention the XRD figure spectrum of use Ophicalcitum.
Fig. 2 by among the present invention the sem photograph of use Ophicalcitum.
Fig. 3 by among the present invention the haemostatic effect figure of different disposal temperature of use Ophicalcitum, wherein the blank group is a nature blood coagulation group, matched group for use commercialization hemorrhage Quikclot (error line is ± 0.25min).
Fig. 4 is the haemostatic effect figure of the calcareous Ophicalcitum of employed richness among the present invention with the Ophicalcitum tcrude ore, and wherein the blank group is a nature blood coagulation group, matched group for use commercialization hemorrhage Quikclot (error line is ± 0.10min).
Fig. 5 is the haemostatic effect figure of composite hemorrhage by a certain percentage of employed Ophicalcitum and zeolite among the present invention, wherein listed ratio is the content of Ophicalcitum, the blank group is a nature blood coagulation group, matched group for use commercialization hemorrhage Quikclot (error line is ± 0.10min).
Fig. 6 is the haemostatic effect figure of composite hemorrhage by a certain percentage of employed Ophicalcitum and montorillonite clay among the present invention, wherein listed ratio is the content of Ophicalcitum, the blank group is a nature blood coagulation group, matched group for use commercialization hemorrhage Quikclot (error line is ± 0.10min).
Accompanying drawing 7 is the Ophicalcitum exothermic effect figure described in the present invention, and its matched group is commercialization hemorrhage Quikclot and modenite (error line is for ± 0.15 ℃).
The specific embodiment
The Ophicalcitum that the present invention selects the Haozhou, Anhui to be produced in specific embodiments.But Ophicalcitum of the present invention is not limited to this, and all main components are that the Ophicalcitum of mineral such as calcite, dolomite, chlorite may be used to the present invention.
The invention is further illustrated by the following examples
A certain amount of Ophicalcitum is put into Chinese medicine grinder, and the pulverizing time is about 5min; The grain diameter that obtains after the pulverizing is at 1 micron～1 millimeter.With the dry 1h in 100 ℃ of baking ovens of the Ophicalcitum after the above-mentioned pulverizing.Its haemostatic effect is good.See accompanying drawing 4,5,6.
Get a certain amount of Ophicalcitum respectively at 300 ℃, 500 ℃, 700 ℃, 900 ℃ roasting 6h, obtain heat treated Ophicalcitum.With above-mentioned Ophicalcitum dry 24h in 100 ℃ of baking ovens.The haemostatic effect of Ophicalcitum is good in 100～500 ℃ of scopes, and its haemostatic effect is seen accompanying drawing 3.
With Ophicalcitum and concentration after pulverizing is the CaCl of 1.0mol/L
2Press the solid-to-liquid ratio of 1g/20m and mix, room temperature reaction 24h uses deionized water wash, and dry 24h obtains the rich calcareous Ophicalcitum of modification in 100 ℃ of baking ovens, and its haemostatic effect is significantly better than the Ophicalcitum tcrude ore, and its haemostatic effect is seen accompanying drawing 4.
Get small beaker, according to Ophicalcitum content is 60%, 80%, 90%, 95% preparation Ophicalcitum, mix with modenite or montorillonite clay, and then the adding mixes with small amount of water, stir evenly 100 ℃ of oven drying 24h, obtain ophicalcitum compound emergency life saving hemostatic, its haemostatic effect and Quikclot are approaching, and the ophicalcitum compound haemostatic effect is significantly better than the Ophicalcitum tcrude ore, shown in accompanying drawing 5,6.
Get one of small beaker, add 5g Ophicalcitum of the present invention, and then add 5ml water, shake up, measure variations in temperature, the heat effect when reflecting the Ophicalcitum hemostasis by variations in temperature with infrared ray temperature-sensitive instrument.Its variations in temperature is littler than Quikclot, and thermal discharge is less, sees accompanying drawing 7.
Get an amount of ophicalcitum compound emergency life saving hemostatic of the present invention 100 ℃ of processing 1h in drying baker, take out a certain amount of pig whole blood (taking from Hangzhou meat processing combine) constant temperature in 25.00 ℃ of constant water bath box simultaneously, treat to begin the blood coagulation experiment behind the pig whole blood temperature stabilization; Get one in test tube, add 40 μ l CaCl
2Solution, and then add 100mg ophicalcitum compound emergency life saving hemostatic of the present invention adds 2ml pig whole blood at last, get rid of evenly with hands, picks up counting simultaneously, measures clotting time on the quiet blender of having proofreaied and correct rotating speed, angle in advance.
Claims (1)
1, a kind of preparation method of externally used ophicalcitum compound emergency life saving hemostatic, the weight percentage that it is characterized in that Ophicalcitum in the hemorrhage component is 60-95%, the weight percentage of auxiliary material natural zeolite or montorillonite clay is 5-40%, and its preparation process is as follows:
1) the natural Ophicalcitum of bulk is ground into particles of different sizes by Chinese medicine grinder, grain diameter is at 1 micron～1 millimeter;
2) Ophicalcitum after will pulverizing was handled 5-6 hour under 300 ℃, 500 ℃, 700 ℃, 900 ℃ temperature through different heat treatment;
3) Ophicalcitum behind the heat treatment carries out calcium chloride modification processing; With Ophicalcitum behind the heat treatment and concentration is that the calcium chloride solution of 0.1～5.0mol/L mixes by the solid-to-liquid ratio of 1g/5-20ml, room temperature reaction 8h, and with deionized water wash three times, and oven dry is residual to there not being water of crystallization, obtains rich calcareous Ophicalcitum;
4) the rich calcareous Ophicalcitum after the modification was handled 1～24 hour under 60～500 ℃ of temperature;
5), press the weight percentage 60-95% of Ophicalcitum in the component, the weight percentage 5-40% uniform mixing of auxiliary material natural zeolite or montorillonite clay with Ophicalcitum and the auxiliary material natural zeolite or the montorillonite clay of heat treated.
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| CN101732340B (en) * | 2010-01-06 | 2012-12-05 | 于翔 | Application of ophicalcitum extract and method for preparing same |
| CN102366640A (en) * | 2011-10-14 | 2012-03-07 | 浙江安吉华埠实业有限公司 | Zeolite tourniquet bandage |
| CN103800940B (en) * | 2012-11-14 | 2015-08-19 | 天津禹王生物医药科技有限公司 | A kind of bleeding-stopping dressing and preparation method |
| CN106075563B (en) * | 2016-08-05 | 2019-08-06 | 山东朱氏药业集团有限公司 | A kind of preparation method of medical bio base compound hemostatic dressing |
| CN114748672B (en) * | 2022-05-07 | 2023-03-31 | 北京化工大学 | Composite hemostatic sponge and preparation method and application thereof |
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